TNFRSF11B Gene Polymorphisms A163G and G11811C in Prediction of Osteoporosis Risk

<!DOCTYPE html> <html lang="en" dir="ltr"> <head>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-P63WKM1TM1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-P63WKM1TM1'); </script>  <script type="text/javascript" > (function(m,e,t,r,i,k,a){m[i]=m[i]||function(){(m[i].a=m[i].a||[]).push(arguments)}; m[i].l=1*new Date(); for (var j = 0; j < document.scripts.length; j++) {if (document.scripts[j].src === r) { return; }} k=e.createElement(t),a=e.getElementsByTagName(t)[0],k.async=1,k.src=r,a.parentNode.insertBefore(k,a)}) (window, document, "script", "https://mc.yandex.ru/metrika/tag.js", "ym"); ym(55165297, "init", { clickmap:false, trackLinks:true, accurateTrackBounce:true, webvisor:false }); </script> <noscript><div><img src="https://mc.yandex.ru/watch/55165297" style="position:absolute; left:-9999px;" alt="" /></div></noscript>    <title>TNFRSF11B Gene Polymorphisms A163G and G11811C in Prediction of Osteoporosis Risk</title> <meta name="description" content="TNFRSF11B Gene Polymorphisms A163G and G11811C in Prediction of Osteoporosis Risk"> <meta name="keywords" content="Osteoporosis, Real-time PCR method, SNP polymorphisms."> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <meta name="citation_title" content="TNFRSF11B Gene Polymorphisms A163G and G11811C in Prediction of Osteoporosis Risk"> <meta name="citation_author" content="Boro艌ov谩 I."> <meta name="citation_author" content="Bernasovsk谩 J."> <meta name="citation_author" content="K木oc J."> <meta name="citation_author" content="Tomkov谩 Z."> <meta name="citation_author" content="Petrej膷铆kov谩 E."> <meta name="citation_author" content="Gabrikov谩 D."> <meta name="citation_author" content="Ma膷ekov谩 S."> <meta name="citation_publication_date" content="2014/02/01"> <meta name="citation_journal_title" content="International Journal of Bioengineering and Life Sciences"> <meta name="citation_volume" content="8"> <meta name="citation_issue" content="1"> <meta name="citation_firstpage" content="30"> <meta name="citation_lastpage" content="32"> <meta name="citation_pdf_url" content="https://publications.waset.org/9997241/pdf"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> 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G11811C in Prediction of Osteoporosis Risk</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Boro%C5%88ov%C3%A1%20I.">Boro艌ov谩 I.</a>, <a href="https://publications.waset.org/search?q=Bernasovsk%C3%A1%20J."> Bernasovsk谩 J.</a>, <a href="https://publications.waset.org/search?q=K%C4%BEoc%20J."> K木oc J.</a>, <a href="https://publications.waset.org/search?q=Tomkov%C3%A1%20Z."> Tomkov谩 Z.</a>, <a href="https://publications.waset.org/search?q=Petrej%C4%8D%C3%ADkov%C3%A1%20E."> Petrej膷铆kov谩 E.</a>, <a href="https://publications.waset.org/search?q=Gabrikov%C3%A1%20D."> Gabrikov谩 D.</a>, <a href="https://publications.waset.org/search?q=Ma%C4%8Dekov%C3%A1%20S."> Ma膷ekov谩 S.</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Osteoporosis is a complex health disease characterized by low bone mineral density, which is determined by an interaction of genetics with metabolic and environmental factors. Current research in genetics of osteoporosis is focused on identification of responsible genes and polymorphisms. TNFRSF11B gene plays a key role in bone remodeling. The aim of this study was to investigate the genotype and allele distribution of A163G (rs3102735) osteoprotegerin gene promoter and G1181C (rs2073618) osteoprotegerin first exon polymorphisms in the group of 180 unrelated postmenopausal women with diagnosed osteoporosis and 180 normal controls. Genomic DNA was isolated from peripheral blood leukocytes using standard methodology. Genotyping for presence of different polymorphisms was performed using the Custom Taqman®SNP Genotyping assays. Hardy-Weinberg equilibrium was tested for each SNP in the groups of participants using the chi-square (χ<sup>2</sup>) test. The distribution of investigated genotypes in the group of patients with osteoporosis were as follows: AA (66.7%), AG (32.2%), GG (1.1%) for A163G polymorphism; GG (19.4%), CG (44.4%), CC (36.1%) for G1181C polymorphism. The distribution of genotypes in normal controls were follows: AA (71.1%), AG (26.1%), GG (2.8%) for A163G polymorphism; GG (22.2%), CG (48.9%), CC (28.9%) for G1181C polymorphism. In A163G polymorphism the variant G allele was more common among patients with osteoporosis: 17.2% versus 15.8% in normal controls. Also, in G1181C polymorphism the phenomenon of more frequent occurrence of C allele in the group of patients with osteoporosis was observed (58.3% versus 53.3%). Genotype and allele distributions showed no significant differences (A163G: χ<sup>2</sup>=0.270, p=0.605; χ<sup>2</sup>=0.250, p=0.616; G1181C: χ<sup>2</sup>= 1.730, p=0.188; χ<sup>2</sup>=1.820, p=0.177). Our results represents an initial study, further studies of more numerous file and associations studies will be carried out. Knowing the distribution of genotypes is important for assessing the impact of these polymorphisms on various parameters associated with osteoporosis. Screening for identification of “at-risk” women likely to develop osteoporosis and initiating subsequent early intervention appears to be most effective strategy to substantially reduce the risks of osteoporosis.</p> <iframe src="https://publications.waset.org/9997241.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Osteoporosis" title="Osteoporosis">Osteoporosis</a>, <a href="https://publications.waset.org/search?q=Real-time%20PCR%20method" title=" Real-time PCR method"> Real-time PCR method</a>, <a href="https://publications.waset.org/search?q=SNP%20polymorphisms." title=" SNP polymorphisms."> SNP polymorphisms.</a> </p> <p class="card-text"><strong>Digital Object Identifier (DOI):</strong> <a href="https://doi.org/10.5281/zenodo.1336919" target="_blank">doi.org/10.5281/zenodo.1336919</a> </p> <a href="https://publications.waset.org/9997241/tnfrsf11b-gene-polymorphisms-a163g-and-g11811c-in-prediction-of-osteoporosis-risk" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/9997241/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/9997241/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/9997241/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/9997241/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/9997241/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/9997241/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/9997241/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/9997241/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/9997241/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/9997241/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/9997241.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2244</span> </span> <p class="card-text"><strong>References:</strong></p> <br>[1] A.P. Diamantopoulos, M. Hoff, M. Hochberg, G. Haugeberg, 藵Predictors of Short- and Long-Term Mortality in Males and Females with Hip Fracture - A Prospective Observational Cohort Study藵, PlosOne, 2013, vol. 8(10), pp. 78169. <br>[2] L.B. Husted, T. Harslof, K. Brixen, 藵Polymorphisms in the osteoprotegerin gene are associated with BMD and osteoporotic fractures藵, Bone, 2010, vol 47(1), pp. 154. <br>[3] B.L. Langdahl, M. Carstens, L. Stenkjaer, E.F. Eriksen, 藵Polymorphisms in the Osteoprotegerin Gene are Associated With Osteoporotic Fractures藵, Journal of Bone and Mineral. Research., 2002, vol. 17(7), pp. 1245-1255. <br>[4] CH. Ling-xia, M. Yi-de, L. Jie, W. Ya-nan, J. Rong, B. Hui, CH. Lin, 藵Association between T245G polymorphisms in the osteoprotegerin gene and bone mineral density in elderly individuals. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, vol. 12(15): 11, pp. 2069-2072. <br>[5] S. Mencej-Bedra膷, J. Prezelj, T. Kocjan et al., 藵The combinations of polymorphisms in vitamin D receptor, osteoprotegerin and tumor necrosis fator superfamily member 11 genes are associated with bone mineral density藵, J. Mol. Endicronol., 2009, vol. 42(3), pp. 239-247. <br>[6] S. Mencej-Bedra膷, J. Pre啪elj, J. Marc, 藵TNFRSF11B gene polymorphisms 1181G>C and T>G as well as haplotype CT influence bone mineral density in postmenopausal women藵, Maturitas, 2011, 69, pp. 263-267. <br>[7] World Health Organisation, 藵Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: Report of a WHO Study Group藵, World Health Organ Tech Rep Ser, 1994, 843, pp. 1-129. <br>[8] K. Zaj铆膷kov谩, I. 沤ofkov谩, 藵Polymorfizmy v kandid谩tn铆ch genech pro osteopor贸zu a jejich asociace nejen s kostn铆m metabolismem藵, Endokrinologie, 2007, vol. 2, pp. 84-88. <br>[9] K. Zaj铆膷kov谩, A. Zemanov谩, M. 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Res., 2008, vol. 57(1), pp. 153-157. </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); });*/ jQuery.get({ url: "https://publications.waset.org/xhr/user-menu", cache: false }).then(function(response){ jQuery('#mainNavMenu').append(response); }); }); </script> </body> </html>

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TNFRSF11B Gene Polymorphisms A163G and G11811C in Prediction of Osteoporosis Risk