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data-dom-id="ProfileCheckPaperUpdate-react-component-0ec79b54-9ea8-4f53-b36d-4bce87399646"></div> <div id="ProfileCheckPaperUpdate-react-component-0ec79b54-9ea8-4f53-b36d-4bce87399646"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Carine Michiels</h1><div class="affiliations-container fake-truncate js-profile-affiliations"><div><a class="u-tcGrayDarker" href="https://lambiotte.academia.edu/">University of Namur</a>, <a class="u-tcGrayDarker" 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class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Carine Michiels</h3></div><div class="js-work-strip profile--work_container" data-work-id="95273591"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273591/Taking_Advantage_of_the_Senescence_Promoting_Effect_of_Olaparib_after_X_ray_and_Proton_Irradiation_Using_the_Senolytic_Drug_ABT_263"><img alt="Research paper thumbnail of Taking Advantage of the Senescence-Promoting Effect of Olaparib after X-ray and Proton Irradiation Using the Senolytic Drug, ABT-263" class="work-thumbnail" src="https://attachments.academia-assets.com/97500434/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273591/Taking_Advantage_of_the_Senescence_Promoting_Effect_of_Olaparib_after_X_ray_and_Proton_Irradiation_Using_the_Senolytic_Drug_ABT_263">Taking Advantage of the Senescence-Promoting Effect of Olaparib after X-ray and Proton Irradiation Using the Senolytic Drug, ABT-263</a></div><div class="wp-workCard_item"><span>Cancers</span><span>, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Radiotherapy (RT) is a key component of cancer treatment. Although improvements have been made ov...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Radiotherapy (RT) is a key component of cancer treatment. Although improvements have been made over the years, radioresistance remains a challenge. For this reason, a better understanding of cell fates in response to RT could improve therapeutic options to enhance cell death and reduce adverse effects. Here, we showed that combining RT (photons and protons) to noncytotoxic concentration of PARP inhibitor, Olaparib, induced a cell line-dependent senescence-like phenotype. The senescent cells were characterized by morphological changes, an increase in p21 mRNA expression as well as an increase in senescence-associated β-galactosidase activity. We demonstrated that these senescent cells could be specifically targeted by Navitoclax (ABT-263), a Bcl-2 family inhibitor. This senolytic drug led to significant cell death when combined with RT and Olaparib, while limited cytotoxicity was observed when used alone. These results demonstrate that a combination of RT with PARP inhibition and sen...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="009fca5db8d9558efc776ad962c7e706" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500434,"asset_id":95273591,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500434/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273591"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273591"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273591; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273591]").text(description); $(".js-view-count[data-work-id=95273591]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273591; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273591']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273591, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "009fca5db8d9558efc776ad962c7e706" } } $('.js-work-strip[data-work-id=95273591]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273591,"title":"Taking Advantage of the Senescence-Promoting Effect of Olaparib after X-ray and Proton Irradiation Using the Senolytic Drug, ABT-263","translated_title":"","metadata":{"abstract":"Radiotherapy (RT) is a key component of cancer treatment. Although improvements have been made over the years, radioresistance remains a challenge. For this reason, a better understanding of cell fates in response to RT could improve therapeutic options to enhance cell death and reduce adverse effects. Here, we showed that combining RT (photons and protons) to noncytotoxic concentration of PARP inhibitor, Olaparib, induced a cell line-dependent senescence-like phenotype. The senescent cells were characterized by morphological changes, an increase in p21 mRNA expression as well as an increase in senescence-associated β-galactosidase activity. We demonstrated that these senescent cells could be specifically targeted by Navitoclax (ABT-263), a Bcl-2 family inhibitor. This senolytic drug led to significant cell death when combined with RT and Olaparib, while limited cytotoxicity was observed when used alone. 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Confrontation between theoretical and experimental data" class="work-thumbnail" src="https://attachments.academia-assets.com/97500497/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273589/Importance_of_various_antioxidant_enzymes_for_cell_stability_Confrontation_between_theoretical_and_experimental_data">Importance of various antioxidant enzymes for cell stability. Confrontation between theoretical and experimental data</a></div><div class="wp-workCard_item"><span>Biochemical Journal</span><span>, 1992</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A theoretical model was developed taking into account the production and destruction of oxygen-de...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A theoretical model was developed taking into account the production and destruction of oxygen-derived free radicals. The steady state of the system was derived by using the rate equations of these reactions, and the stability of the system was tested. In the simplified model, only one stable steady state was found. However, we know that glutathione peroxidase can be inhibited by hydroperoxides, and, when incorporated into the model, this effect led to a complex situation with the presence of some stable and some unstable domains according to the concentration of either the enzyme or the hydroperoxide. This qualitative description of the system was compared with experimental data on the protection given by three antioxidant enzymes, and concordance of data was found which allows some quantification of the system. 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"profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95273587"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273587/Monte_Carlo_Calculation_of_Radioimmunotherapy_with90Y_177Lu_131I_124I_and188Re_Nanoobjects_Choice_of_the_Best_Radionuclide_for_Solid_Tumour_Treatment_by_Using_TCP_and_NTCP_Concepts"><img alt="Research paper thumbnail of Monte Carlo Calculation of Radioimmunotherapy with90Y-,177Lu-,131I-,124I-, and188Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts" class="work-thumbnail" src="https://attachments.academia-assets.com/97500433/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273587/Monte_Carlo_Calculation_of_Radioimmunotherapy_with90Y_177Lu_131I_124I_and188Re_Nanoobjects_Choice_of_the_Best_Radionuclide_for_Solid_Tumour_Treatment_by_Using_TCP_and_NTCP_Concepts">Monte Carlo Calculation of Radioimmunotherapy with90Y-,177Lu-,131I-,124I-, and188Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts</a></div><div class="wp-workCard_item"><span>Computational and Mathematical Methods in Medicine</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Radioimmunotherapy has shown that the use of monoclonal antibodies combined with a radioisotope l...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Radioimmunotherapy has shown that the use of monoclonal antibodies combined with a radioisotope like131I or90Y still remains ineffective for solid and radioresistant tumour treatment. Previous simulations have revealed that an increase in the number of90Y labelled to each antibody or nanoobject could be a solution to improve treatment output. It now seems important to assess the treatment output and toxicity when radionuclides such as90Y,177Lu,131I,124I, and188Re are used. Tumour control probability (TCP) and normal tissue complication probability (NTCP) curves versus the number of radionuclides per nanoobject were computed with MCNPX to evaluate treatment efficacy for solid tumours and to predict the incidence of surrounding side effects. Analyses were carried out for two solid tumour sizes of 0.5 and 1.0 cm radius and for nanoobject (i.e., a radiolabelled antibody) distributed uniformly or nonuniformly throughout a solid tumour (e.g., Non-small-cell-lung cancer (NSCLC)).90Y and188...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e9f11b7fc3479568369516e96bf50b40" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500433,"asset_id":95273587,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500433/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273587"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273587"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273587; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273587]").text(description); $(".js-view-count[data-work-id=95273587]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273587; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273587']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273587, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e9f11b7fc3479568369516e96bf50b40" } } $('.js-work-strip[data-work-id=95273587]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273587,"title":"Monte Carlo Calculation of Radioimmunotherapy with90Y-,177Lu-,131I-,124I-, and188Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts","translated_title":"","metadata":{"abstract":"Radioimmunotherapy has shown that the use of monoclonal antibodies combined with a radioisotope like131I or90Y still remains ineffective for solid and radioresistant tumour treatment. 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System" class="work-thumbnail" src="https://attachments.academia-assets.com/97500477/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273584/Effects_of_Alpha_Particle_and_Proton_Beam_Irradiation_as_Putative_Cross_Talk_between_A549_Cancer_Cells_and_the_Endothelial_Cells_in_a_Co_Culture_System">Effects of Alpha Particle and Proton Beam Irradiation as Putative Cross-Talk between A549 Cancer Cells and the Endothelial Cells in a Co-Culture System</a></div><div class="wp-workCard_item"><span>Cancers</span><span>, Jan 18, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">High-LET ion irradiation is being more and more often used to control tumors in patients. Given t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">High-LET ion irradiation is being more and more often used to control tumors in patients. Given that tumors are now considered as complex organs composed of multiple cell types that can influence radiosensitivity, we investigated the effects of proton and alpha particle irradiation on the possible radioprotective cross-talk between cancer and endothelial cells. We designed new irradiation chambers that allow co-culture study of cells irradiated with a particle beam. A549 lung carcinoma cells and endothelial cells (EC) were exposed to 1.5 Gy of proton beam or 1 and 2 Gy of alpha particles. Cell responses were studied by clonogenic assays and cell cycle was analyzed by flow cytometry. Gene expression studies were performed using Taqman low density array and by RT-qPCR. A549 cells and EC displayed similar survival fraction and they had similar cell cycle distribution when irradiated alone or in co-culture. Both types of irradiation induced the overexpression of genes involved in cell g...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="389ab1bc5af9c89abd99402fa9f07ac7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500477,"asset_id":95273584,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500477/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273584"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273584"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273584; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273584]").text(description); $(".js-view-count[data-work-id=95273584]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273584; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273584']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273584, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "389ab1bc5af9c89abd99402fa9f07ac7" } } $('.js-work-strip[data-work-id=95273584]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273584,"title":"Effects of Alpha Particle and Proton Beam Irradiation as Putative Cross-Talk between A549 Cancer Cells and the Endothelial Cells in a Co-Culture System","translated_title":"","metadata":{"abstract":"High-LET ion irradiation is being more and more often used to control tumors in patients. Given that tumors are now considered as complex organs composed of multiple cell types that can influence radiosensitivity, we investigated the effects of proton and alpha particle irradiation on the possible radioprotective cross-talk between cancer and endothelial cells. We designed new irradiation chambers that allow co-culture study of cells irradiated with a particle beam. A549 lung carcinoma cells and endothelial cells (EC) were exposed to 1.5 Gy of proton beam or 1 and 2 Gy of alpha particles. Cell responses were studied by clonogenic assays and cell cycle was analyzed by flow cytometry. Gene expression studies were performed using Taqman low density array and by RT-qPCR. A549 cells and EC displayed similar survival fraction and they had similar cell cycle distribution when irradiated alone or in co-culture. Both types of irradiation induced the overexpression of genes involved in cell g...","publication_date":{"day":18,"month":1,"year":2015,"errors":{}},"publication_name":"Cancers"},"translated_abstract":"High-LET ion irradiation is being more and more often used to control tumors in patients. Given that tumors are now considered as complex organs composed of multiple cell types that can influence radiosensitivity, we investigated the effects of proton and alpha particle irradiation on the possible radioprotective cross-talk between cancer and endothelial cells. We designed new irradiation chambers that allow co-culture study of cells irradiated with a particle beam. A549 lung carcinoma cells and endothelial cells (EC) were exposed to 1.5 Gy of proton beam or 1 and 2 Gy of alpha particles. Cell responses were studied by clonogenic assays and cell cycle was analyzed by flow cytometry. Gene expression studies were performed using Taqman low density array and by RT-qPCR. A549 cells and EC displayed similar survival fraction and they had similar cell cycle distribution when irradiated alone or in co-culture. Both types of irradiation induced the overexpression of genes involved in cell g...","internal_url":"https://www.academia.edu/95273584/Effects_of_Alpha_Particle_and_Proton_Beam_Irradiation_as_Putative_Cross_Talk_between_A549_Cancer_Cells_and_the_Endothelial_Cells_in_a_Co_Culture_System","translated_internal_url":"","created_at":"2023-01-18T22:56:01.051-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33692092,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97500477,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500477/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/97500477/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effects_of_Alpha_Particle_and_Proton_Bea.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500477/pdf-libre.pdf?1674114592=\u0026response-content-disposition=attachment%3B+filename%3DEffects_of_Alpha_Particle_and_Proton_Bea.pdf\u0026Expires=1732731799\u0026Signature=evzeN-Qd8CdM8sIGA2nJeSjkT1thtjl8Vauh1LGZsgA6Jb5WoB-g2B3O08iWRE3uuUIme9EFfNF6sWyEfZirc1K3CN2VEaY8PWUKfuN7s135a~wnf27zAFKwjWOU0z4Gi0HC92zug0mE026-g11J2~1DbML-V0drUcHgr1OKVUbtmDxvfUVlNLac-xrWxb3v2foh640j~NCJb8gOR~8hvjb~Ojss1lIdMGj6103YImfwk43VEDPvnqN1qdb1W2PWcevl6O7JJeX6tNv3WwlnY3849e2Xsx3a3X0TpLhFV8N62y13Urq-0~P9R-M1Yq6bZ3adaUuNUpwKAKMcpTDYGw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Effects_of_Alpha_Particle_and_Proton_Beam_Irradiation_as_Putative_Cross_Talk_between_A549_Cancer_Cells_and_the_Endothelial_Cells_in_a_Co_Culture_System","translated_slug":"","page_count":22,"language":"en","content_type":"Work","owner":{"id":33692092,"first_name":"Carine","middle_initials":null,"last_name":"Michiels","page_name":"CarineMichiels","domain_name":"lambiotte","created_at":"2015-08-06T23:03:11.643-07:00","display_name":"Carine Michiels","url":"https://lambiotte.academia.edu/CarineMichiels"},"attachments":[{"id":97500477,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500477/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/97500477/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effects_of_Alpha_Particle_and_Proton_Bea.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500477/pdf-libre.pdf?1674114592=\u0026response-content-disposition=attachment%3B+filename%3DEffects_of_Alpha_Particle_and_Proton_Bea.pdf\u0026Expires=1732731799\u0026Signature=evzeN-Qd8CdM8sIGA2nJeSjkT1thtjl8Vauh1LGZsgA6Jb5WoB-g2B3O08iWRE3uuUIme9EFfNF6sWyEfZirc1K3CN2VEaY8PWUKfuN7s135a~wnf27zAFKwjWOU0z4Gi0HC92zug0mE026-g11J2~1DbML-V0drUcHgr1OKVUbtmDxvfUVlNLac-xrWxb3v2foh640j~NCJb8gOR~8hvjb~Ojss1lIdMGj6103YImfwk43VEDPvnqN1qdb1W2PWcevl6O7JJeX6tNv3WwlnY3849e2Xsx3a3X0TpLhFV8N62y13Urq-0~P9R-M1Yq6bZ3adaUuNUpwKAKMcpTDYGw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":9113,"name":"Cell Cycle","url":"https://www.academia.edu/Documents/in/Cell_Cycle"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":37782,"name":"Cell Culture","url":"https://www.academia.edu/Documents/in/Cell_Culture"},{"id":71510,"name":"Endothelial Cells","url":"https://www.academia.edu/Documents/in/Endothelial_Cells"},{"id":72265,"name":"Hadrontherapy","url":"https://www.academia.edu/Documents/in/Hadrontherapy"},{"id":132620,"name":"Radiobiology","url":"https://www.academia.edu/Documents/in/Radiobiology"},{"id":439023,"name":"Irradiation","url":"https://www.academia.edu/Documents/in/Irradiation"},{"id":452367,"name":"Crosstalk","url":"https://www.academia.edu/Documents/in/Crosstalk"},{"id":764243,"name":"Radioresistance","url":"https://www.academia.edu/Documents/in/Radioresistance"},{"id":879919,"name":"Radiosensitivity","url":"https://www.academia.edu/Documents/in/Radiosensitivity"},{"id":1010893,"name":"Cancers","url":"https://www.academia.edu/Documents/in/Cancers"},{"id":1244098,"name":"Clonogenic Assay","url":"https://www.academia.edu/Documents/in/Clonogenic_Assay"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95273582"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273582/Heat_Modified_Citrus_Pectin_Induces_Apoptosis_Like_Cell_Death_and_Autophagy_in_HepG2_and_A549_Cancer_Cells"><img alt="Research paper thumbnail of Heat-Modified Citrus Pectin Induces Apoptosis-Like Cell Death and Autophagy in HepG2 and A549 Cancer Cells" class="work-thumbnail" src="https://attachments.academia-assets.com/97500495/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273582/Heat_Modified_Citrus_Pectin_Induces_Apoptosis_Like_Cell_Death_and_Autophagy_in_HepG2_and_A549_Cancer_Cells">Heat-Modified Citrus Pectin Induces Apoptosis-Like Cell Death and Autophagy in HepG2 and A549 Cancer Cells</a></div><div class="wp-workCard_item"><span>PLOS ONE</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5e603fbe03faaa0d8980be6dc9d632da" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500495,"asset_id":95273582,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500495/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273582"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273582"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273582; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273582]").text(description); $(".js-view-count[data-work-id=95273582]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273582; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273582']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273582, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5e603fbe03faaa0d8980be6dc9d632da" } } $('.js-work-strip[data-work-id=95273582]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273582,"title":"Heat-Modified Citrus Pectin Induces Apoptosis-Like Cell Death and Autophagy in HepG2 and A549 Cancer Cells","translated_title":"","metadata":{"publisher":"Public Library of Science (PLoS)","grobid_abstract":"Cancer is still one of the leading causes of death worldwide, and finding new treatments remains a major challenge. Previous studies showed that modified forms of pectin, a complex polysaccharide present in the primary plant cell wall, possess anticancer properties. Nevertheless, the mechanism of action of modified pectin and the pathways involved are unclear. Here, we show that citrus pectin modified by heat treatment induced cell death in HepG2 and A549 cells. The induced cell death differs from classical apoptosis because no DNA cleavage was observed. In addition, Z-VAD-fmk, a pan-caspase inhibitor, did not influence the observed cell death in HepG2 cells but appeared to be partly protective in A549 cells, indicating that heat-modified citrus pectin might induce caspase-independent cell death. An increase in the abundance of the phosphatidylethanolamine-conjugated Light Chain 3 (LC3) protein and a decrease in p62 protein abundance were observed in both cell types when incubated in the presence of heat-modified citrus pectin. These results indicate the activation of autophagy. To our knowledge, this is the first time that autophagy has been revealed in cells incubated in the presence of a modified form of pectin. This autophagy activation appears to be protective, at least for A549 cells, because its inhibition with 3-methyladenine increased the observed modified pectin-induced cytotoxicity. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95273581"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273581/A_new_experimental_model_to_study_oxygen_toxicity"><img alt="Research paper thumbnail of A new experimental model to study oxygen toxicity" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273581/A_new_experimental_model_to_study_oxygen_toxicity">A new experimental model to study oxygen toxicity</a></div><div class="wp-workCard_item"><span>Archives internationales de physiologie et de biochimie</span><span>, 1986</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">An experimental model was developed in order to study the protective effect of antioxidant molecu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">An experimental model was developed in order to study the protective effect of antioxidant molecules. Human diploid WI-38 fibroblasts were cultivated under 2 atm of 95% O2. Antioxidants like alpha-tocopherol or superoxide dismutase (SOD) were added respectively in the culture medium or directly inside the cell through a microinjection technique. With both antioxidant molecules a protection was observed. In the control experiment, cells died within 6 or 8 days depending on the confluency and the malonaldehyde content increased sharply. This model represents a new tool in order to test other antioxidant systems towards an oxidative stress.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273581"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273581"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273581; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273581]").text(description); $(".js-view-count[data-work-id=95273581]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273581; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273581']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273581, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=95273581]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273581,"title":"A new experimental model to study oxygen toxicity","translated_title":"","metadata":{"abstract":"An experimental model was developed in order to study the protective effect of antioxidant molecules. Human diploid WI-38 fibroblasts were cultivated under 2 atm of 95% O2. Antioxidants like alpha-tocopherol or superoxide dismutase (SOD) were added respectively in the culture medium or directly inside the cell through a microinjection technique. With both antioxidant molecules a protection was observed. In the control experiment, cells died within 6 or 8 days depending on the confluency and the malonaldehyde content increased sharply. This model represents a new tool in order to test other antioxidant systems towards an oxidative stress.","publication_date":{"day":null,"month":null,"year":1986,"errors":{}},"publication_name":"Archives internationales de physiologie et de biochimie"},"translated_abstract":"An experimental model was developed in order to study the protective effect of antioxidant molecules. Human diploid WI-38 fibroblasts were cultivated under 2 atm of 95% O2. Antioxidants like alpha-tocopherol or superoxide dismutase (SOD) were added respectively in the culture medium or directly inside the cell through a microinjection technique. With both antioxidant molecules a protection was observed. In the control experiment, cells died within 6 or 8 days depending on the confluency and the malonaldehyde content increased sharply. This model represents a new tool in order to test other antioxidant systems towards an oxidative stress.","internal_url":"https://www.academia.edu/95273581/A_new_experimental_model_to_study_oxygen_toxicity","translated_internal_url":"","created_at":"2023-01-18T22:56:00.812-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33692092,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"A_new_experimental_model_to_study_oxygen_toxicity","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33692092,"first_name":"Carine","middle_initials":null,"last_name":"Michiels","page_name":"CarineMichiels","domain_name":"lambiotte","created_at":"2015-08-06T23:03:11.643-07:00","display_name":"Carine Michiels","url":"https://lambiotte.academia.edu/CarineMichiels"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51711,"name":"Antioxidants","url":"https://www.academia.edu/Documents/in/Antioxidants"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":103339,"name":"Antioxidant","url":"https://www.academia.edu/Documents/in/Antioxidant"},{"id":156734,"name":"Vitamin E","url":"https://www.academia.edu/Documents/in/Vitamin_E"},{"id":212467,"name":"Microinjection","url":"https://www.academia.edu/Documents/in/Microinjection"},{"id":213343,"name":"Superoxide Dismutase","url":"https://www.academia.edu/Documents/in/Superoxide_Dismutase"},{"id":380825,"name":"Oxygen","url":"https://www.academia.edu/Documents/in/Oxygen"},{"id":418942,"name":"Oxygen Toxicity","url":"https://www.academia.edu/Documents/in/Oxygen_Toxicity"},{"id":2533047,"name":"fibroblasts","url":"https://www.academia.edu/Documents/in/fibroblasts"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95273580"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273580/Taxol_induced_Unfolded_Protein_Response_activation_in_breast_cancer_cells_exposed_to_hypoxia_ATF4_activation_regulates_autophagy_and_inhibits_apoptosis"><img alt="Research paper thumbnail of Taxol-induced Unfolded Protein Response activation in breast cancer cells exposed to hypoxia: ATF4 activation regulates autophagy and inhibits apoptosis" class="work-thumbnail" src="https://attachments.academia-assets.com/97500471/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273580/Taxol_induced_Unfolded_Protein_Response_activation_in_breast_cancer_cells_exposed_to_hypoxia_ATF4_activation_regulates_autophagy_and_inhibits_apoptosis">Taxol-induced Unfolded Protein Response activation in breast cancer cells exposed to hypoxia: ATF4 activation regulates autophagy and inhibits apoptosis</a></div><div class="wp-workCard_item"><span>The international journal of biochemistry & cell biology</span><span>, Jan 24, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Understanding the mechanisms responsible for the resistance against chemotherapy-induced cell dea...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Understanding the mechanisms responsible for the resistance against chemotherapy-induced cell death is still of great interest since the number of patients with cancer increases and relapse is commonly observed. Indeed, the development of hypoxic regions as well as UPR (unfolded protein response) activation are known to promote cancer cell adaptive responses to the stressful tumor microenvironment and resistance against anti-cancer therapies. Therefore, the impact of UPR combined to hypoxia on autophagy and apoptosis activation during taxol exposure was investigated in MDA-MB-231 and T47D breast cancer cells. The results showed that taxol rapidly induced UPR activation and that hypoxia modulated taxol-induced UPR activation differently according to the different UPR pathways (PERK, ATF6 and IRE1α). The putative involvement of these signalling pathways in autophagy or in apoptosis regulation in response to taxol exposure was investigated. However, while no link between the activation...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9220b483e16c2a61c9db832e9e430753" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500471,"asset_id":95273580,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500471/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273580"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273580"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273580; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273580]").text(description); $(".js-view-count[data-work-id=95273580]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273580; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273580']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273580, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9220b483e16c2a61c9db832e9e430753" } } $('.js-work-strip[data-work-id=95273580]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273580,"title":"Taxol-induced Unfolded Protein Response activation in breast cancer cells exposed to hypoxia: ATF4 activation regulates autophagy and inhibits apoptosis","translated_title":"","metadata":{"abstract":"Understanding the mechanisms responsible for the resistance against chemotherapy-induced cell death is still of great interest since the number of patients with cancer increases and relapse is commonly observed. Indeed, the development of hypoxic regions as well as UPR (unfolded protein response) activation are known to promote cancer cell adaptive responses to the stressful tumor microenvironment and resistance against anti-cancer therapies. Therefore, the impact of UPR combined to hypoxia on autophagy and apoptosis activation during taxol exposure was investigated in MDA-MB-231 and T47D breast cancer cells. The results showed that taxol rapidly induced UPR activation and that hypoxia modulated taxol-induced UPR activation differently according to the different UPR pathways (PERK, ATF6 and IRE1α). The putative involvement of these signalling pathways in autophagy or in apoptosis regulation in response to taxol exposure was investigated. However, while no link between the activation...","publication_date":{"day":24,"month":1,"year":2015,"errors":{}},"publication_name":"The international journal of biochemistry \u0026 cell biology"},"translated_abstract":"Understanding the mechanisms responsible for the resistance against chemotherapy-induced cell death is still of great interest since the number of patients with cancer increases and relapse is commonly observed. Indeed, the development of hypoxic regions as well as UPR (unfolded protein response) activation are known to promote cancer cell adaptive responses to the stressful tumor microenvironment and resistance against anti-cancer therapies. Therefore, the impact of UPR combined to hypoxia on autophagy and apoptosis activation during taxol exposure was investigated in MDA-MB-231 and T47D breast cancer cells. The results showed that taxol rapidly induced UPR activation and that hypoxia modulated taxol-induced UPR activation differently according to the different UPR pathways (PERK, ATF6 and IRE1α). The putative involvement of these signalling pathways in autophagy or in apoptosis regulation in response to taxol exposure was investigated. However, while no link between the activation...","internal_url":"https://www.academia.edu/95273580/Taxol_induced_Unfolded_Protein_Response_activation_in_breast_cancer_cells_exposed_to_hypoxia_ATF4_activation_regulates_autophagy_and_inhibits_apoptosis","translated_internal_url":"","created_at":"2023-01-18T22:56:00.707-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33692092,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97500471,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500471/thumbnails/1.jpg","file_name":"Notte_UPR_2015_IJBCB.pdf","download_url":"https://www.academia.edu/attachments/97500471/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Taxol_induced_Unfolded_Protein_Response.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500471/Notte_UPR_2015_IJBCB-libre.pdf?1674114617=\u0026response-content-disposition=attachment%3B+filename%3DTaxol_induced_Unfolded_Protein_Response.pdf\u0026Expires=1732731799\u0026Signature=NniyRK~fWqY9e0sVYMYu7M64zJQOoKWNE~N6c5~j3PUQsZoJ4xoGLRhsn3Y8C0KBfrxda6pCXlVlY-qTnIHPajU1R2K3FI4PA2zUibqc2DAW34Jj1WHvDfZnOQCGV0BMEvfObXEOm1Y~8oKSkL4OsbVvbkZGwoUelUtoht4RSbsycNJUSr74VvIt4h-yXw6KORO7reudyTQ21IC1zkCGRMqYGaBkNA0BAFTGHC~e9quAXqBpZTSUmZYeJkOgEMtGs5GNXizWMdjYl~xguP2T0LGZ~k8NRGkwvgUL5I2mgCOaQSLHcAg~EJeK639cqRlcXkw1D1tzLlZJRrEx2wQREw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Taxol_induced_Unfolded_Protein_Response_activation_in_breast_cancer_cells_exposed_to_hypoxia_ATF4_activation_regulates_autophagy_and_inhibits_apoptosis","translated_slug":"","page_count":15,"language":"en","content_type":"Work","owner":{"id":33692092,"first_name":"Carine","middle_initials":null,"last_name":"Michiels","page_name":"CarineMichiels","domain_name":"lambiotte","created_at":"2015-08-06T23:03:11.643-07:00","display_name":"Carine Michiels","url":"https://lambiotte.academia.edu/CarineMichiels"},"attachments":[{"id":97500471,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500471/thumbnails/1.jpg","file_name":"Notte_UPR_2015_IJBCB.pdf","download_url":"https://www.academia.edu/attachments/97500471/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Taxol_induced_Unfolded_Protein_Response.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500471/Notte_UPR_2015_IJBCB-libre.pdf?1674114617=\u0026response-content-disposition=attachment%3B+filename%3DTaxol_induced_Unfolded_Protein_Response.pdf\u0026Expires=1732731799\u0026Signature=NniyRK~fWqY9e0sVYMYu7M64zJQOoKWNE~N6c5~j3PUQsZoJ4xoGLRhsn3Y8C0KBfrxda6pCXlVlY-qTnIHPajU1R2K3FI4PA2zUibqc2DAW34Jj1WHvDfZnOQCGV0BMEvfObXEOm1Y~8oKSkL4OsbVvbkZGwoUelUtoht4RSbsycNJUSr74VvIt4h-yXw6KORO7reudyTQ21IC1zkCGRMqYGaBkNA0BAFTGHC~e9quAXqBpZTSUmZYeJkOgEMtGs5GNXizWMdjYl~xguP2T0LGZ~k8NRGkwvgUL5I2mgCOaQSLHcAg~EJeK639cqRlcXkw1D1tzLlZJRrEx2wQREw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6802,"name":"Breast Cancer","url":"https://www.academia.edu/Documents/in/Breast_Cancer"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":10990,"name":"Hypoxia","url":"https://www.academia.edu/Documents/in/Hypoxia"},{"id":17923,"name":"Autophagy","url":"https://www.academia.edu/Documents/in/Autophagy"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":117915,"name":"Unfolded Protein Response","url":"https://www.academia.edu/Documents/in/Unfolded_Protein_Response"},{"id":168351,"name":"Paclitaxel","url":"https://www.academia.edu/Documents/in/Paclitaxel"},{"id":175490,"name":"Programmed cell death","url":"https://www.academia.edu/Documents/in/Programmed_cell_death"},{"id":324687,"name":"UPR","url":"https://www.academia.edu/Documents/in/UPR"},{"id":506082,"name":"Cancer Cell","url":"https://www.academia.edu/Documents/in/Cancer_Cell"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":2039739,"name":"Down-Regulation","url":"https://www.academia.edu/Documents/in/Down-Regulation"},{"id":2847999,"name":"Breast Neoplasms","url":"https://www.academia.edu/Documents/in/Breast_Neoplasms"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95273579"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273579/Cycling_hypoxia_induces_a_specific_amplified_inflammatory_phenotype_in_endothelial_cells_and_enhances_tumor_promoting_inflammation_in_vivo"><img alt="Research paper thumbnail of Cycling hypoxia induces a specific amplified inflammatory phenotype in endothelial cells and enhances tumor-promoting inflammation in vivo" class="work-thumbnail" src="https://attachments.academia-assets.com/97500509/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273579/Cycling_hypoxia_induces_a_specific_amplified_inflammatory_phenotype_in_endothelial_cells_and_enhances_tumor_promoting_inflammation_in_vivo">Cycling hypoxia induces a specific amplified inflammatory phenotype in endothelial cells and enhances tumor-promoting inflammation in vivo</a></div><div class="wp-workCard_item"><span>Neoplasia (New York, N.Y.)</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abnormal architecture of the tumor blood network, as well as heterogeneous erythrocyte flow, lead...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abnormal architecture of the tumor blood network, as well as heterogeneous erythrocyte flow, leads to temporal fluctuations in tissue oxygen tension exposing tumor and stromal cells to cycling hypoxia. Inflammation is another feature of tumor microenvironment and is considered as a new enabling characteristic of tumor progression. As cycling hypoxia is known to participate in tumor aggressiveness, the purpose of this study was to evaluate its role in tumor-promoting inflammation. Firstly, we assessed the impact of cycling hypoxia in vitro on endothelial inflammatory response induced by tumor necrosis factor α. Results showed that endothelial cells exposed to cycling hypoxia displayed an amplified proinflammatory phenotype, characterized by an increased expression of inflammatory cytokines, namely, interleukin (IL)-6 and IL-8; by an increased expression of adhesion molecules, in particular intercellular adhesion molecule-1 (ICAM-1); and consequently by an increase in THP-1 monocyte a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e7fbac6e8c8c7b907875fff053c3fc67" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500509,"asset_id":95273579,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500509/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273579"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273579"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273579; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273579]").text(description); $(".js-view-count[data-work-id=95273579]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273579; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273579']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273579, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e7fbac6e8c8c7b907875fff053c3fc67" } } $('.js-work-strip[data-work-id=95273579]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273579,"title":"Cycling hypoxia induces a specific amplified inflammatory phenotype in endothelial cells and enhances tumor-promoting inflammation in vivo","translated_title":"","metadata":{"abstract":"Abnormal architecture of the tumor blood network, as well as heterogeneous erythrocyte flow, leads to temporal fluctuations in tissue oxygen tension exposing tumor and stromal cells to cycling hypoxia. Inflammation is another feature of tumor microenvironment and is considered as a new enabling characteristic of tumor progression. As cycling hypoxia is known to participate in tumor aggressiveness, the purpose of this study was to evaluate its role in tumor-promoting inflammation. Firstly, we assessed the impact of cycling hypoxia in vitro on endothelial inflammatory response induced by tumor necrosis factor α. Results showed that endothelial cells exposed to cycling hypoxia displayed an amplified proinflammatory phenotype, characterized by an increased expression of inflammatory cytokines, namely, interleukin (IL)-6 and IL-8; by an increased expression of adhesion molecules, in particular intercellular adhesion molecule-1 (ICAM-1); and consequently by an increase in THP-1 monocyte a...","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Neoplasia (New York, N.Y.)"},"translated_abstract":"Abnormal architecture of the tumor blood network, as well as heterogeneous erythrocyte flow, leads to temporal fluctuations in tissue oxygen tension exposing tumor and stromal cells to cycling hypoxia. Inflammation is another feature of tumor microenvironment and is considered as a new enabling characteristic of tumor progression. As cycling hypoxia is known to participate in tumor aggressiveness, the purpose of this study was to evaluate its role in tumor-promoting inflammation. Firstly, we assessed the impact of cycling hypoxia in vitro on endothelial inflammatory response induced by tumor necrosis factor α. Results showed that endothelial cells exposed to cycling hypoxia displayed an amplified proinflammatory phenotype, characterized by an increased expression of inflammatory cytokines, namely, interleukin (IL)-6 and IL-8; by an increased expression of adhesion molecules, in particular intercellular adhesion molecule-1 (ICAM-1); and consequently by an increase in THP-1 monocyte a...","internal_url":"https://www.academia.edu/95273579/Cycling_hypoxia_induces_a_specific_amplified_inflammatory_phenotype_in_endothelial_cells_and_enhances_tumor_promoting_inflammation_in_vivo","translated_internal_url":"","created_at":"2023-01-18T22:56:00.598-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33692092,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97500509,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500509/thumbnails/1.jpg","file_name":"pmc4309725.pdf","download_url":"https://www.academia.edu/attachments/97500509/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cycling_hypoxia_induces_a_specific_ampli.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500509/pmc4309725-libre.pdf?1674114575=\u0026response-content-disposition=attachment%3B+filename%3DCycling_hypoxia_induces_a_specific_ampli.pdf\u0026Expires=1732731799\u0026Signature=CQ6Oucx2GhWRSm7UATjVLyYkM53HfC~PoM53fNxT2BDZHTWmT0PDO0r1ejjgD4N064ZeZovYJaU5Fx5r6uNOznTZxw7bjVLkwrT2Uu1bHoWU9myxEU6EEaLzD3Z2rDVBS73SYFeRp7KnKzICQWdaCK-Js1oGiluG3O5ePCmzZktYs7wCkEgSCLnBb6kk1bi8gT0G9rfiqJS92fsWBAuUs5OM2k4Fi04wYZqLOsNBi7Ls4PsyO3AG1WNNgT6hbgxmoWGuS~5rhJ0fnYoz8S2WwnMM0OVFvK0YbL4eHQFPTMFvpzU8TNbcOIUkrU69f3-DgSc2Wymek3S657DGyzG-Iw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Cycling_hypoxia_induces_a_specific_amplified_inflammatory_phenotype_in_endothelial_cells_and_enhances_tumor_promoting_inflammation_in_vivo","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":33692092,"first_name":"Carine","middle_initials":null,"last_name":"Michiels","page_name":"CarineMichiels","domain_name":"lambiotte","created_at":"2015-08-06T23:03:11.643-07:00","display_name":"Carine Michiels","url":"https://lambiotte.academia.edu/CarineMichiels"},"attachments":[{"id":97500509,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500509/thumbnails/1.jpg","file_name":"pmc4309725.pdf","download_url":"https://www.academia.edu/attachments/97500509/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cycling_hypoxia_induces_a_specific_ampli.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500509/pmc4309725-libre.pdf?1674114575=\u0026response-content-disposition=attachment%3B+filename%3DCycling_hypoxia_induces_a_specific_ampli.pdf\u0026Expires=1732731799\u0026Signature=CQ6Oucx2GhWRSm7UATjVLyYkM53HfC~PoM53fNxT2BDZHTWmT0PDO0r1ejjgD4N064ZeZovYJaU5Fx5r6uNOznTZxw7bjVLkwrT2Uu1bHoWU9myxEU6EEaLzD3Z2rDVBS73SYFeRp7KnKzICQWdaCK-Js1oGiluG3O5ePCmzZktYs7wCkEgSCLnBb6kk1bi8gT0G9rfiqJS92fsWBAuUs5OM2k4Fi04wYZqLOsNBi7Ls4PsyO3AG1WNNgT6hbgxmoWGuS~5rhJ0fnYoz8S2WwnMM0OVFvK0YbL4eHQFPTMFvpzU8TNbcOIUkrU69f3-DgSc2Wymek3S657DGyzG-Iw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":9111,"name":"Cytokines","url":"https://www.academia.edu/Documents/in/Cytokines"},{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":67133,"name":"Anoxia","url":"https://www.academia.edu/Documents/in/Anoxia"},{"id":71510,"name":"Endothelial Cells","url":"https://www.academia.edu/Documents/in/Endothelial_Cells"},{"id":71936,"name":"Tumor Hypoxia","url":"https://www.academia.edu/Documents/in/Tumor_Hypoxia"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":123418,"name":"NF-kappa B","url":"https://www.academia.edu/Documents/in/NF-kappa_B"},{"id":151098,"name":"Neoplasia","url":"https://www.academia.edu/Documents/in/Neoplasia"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":469018,"name":"Neoplasms","url":"https://www.academia.edu/Documents/in/Neoplasms"},{"id":474029,"name":"Tumor necrosis factor-alpha","url":"https://www.academia.edu/Documents/in/Tumor_necrosis_factor-alpha"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis"},{"id":4073093,"name":"Inflammation Mediators","url":"https://www.academia.edu/Documents/in/Inflammation_Mediators"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95273578"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273578/Effect_of_Hydroxyethylrutosides_on_Hypoxial_Induced_Neutrophil_Adherence_to_Umbilical_Vein_Endothelium"><img alt="Research paper thumbnail of Effect of Hydroxyethylrutosides on Hypoxial-Induced Neutrophil Adherence to Umbilical Vein Endothelium" class="work-thumbnail" src="https://attachments.academia-assets.com/97500468/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273578/Effect_of_Hydroxyethylrutosides_on_Hypoxial_Induced_Neutrophil_Adherence_to_Umbilical_Vein_Endothelium">Effect of Hydroxyethylrutosides on Hypoxial-Induced Neutrophil Adherence to Umbilical Vein Endothelium</a></div><div class="wp-workCard_item"><span>Cardiovascular Drugs and Therapy - CARDIOVASC DRUG THERAPY</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A clinically available mixture of hydroxyethylrutosides (HR) was examined as a protector against ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A clinically available mixture of hydroxyethylrutosides (HR) was examined as a protector against endothelial cell activation by hypoxia in perfused human umbilical vein. The results showed that 500 µg/mL HR totally inhibited the adherence of human unstimulated neutrophils to the endothelium of umbilical vein incubated in hypoxic conditions. This inhibition was confirmed by a morphological study performed by scanning electron microscopy. In addition, neutrophils adherent to the hypoxic umbilical vein endothelium became activated, as evidenced by the increased release of superoxide anions and synthesis of leukotriene B4. These processes could also be inhibited by HR. In conclusion, the results of this study suggest that the improvement in venous insufficiency observed clinically with HR could, in part, be the result of their ability to inhibit the recruitment and activation of neutrophils by endothelium activated during blood stasis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a909f33b6a87c172666a0258c39316fe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500468,"asset_id":95273578,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500468/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273578"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273578"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273578; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273578]").text(description); $(".js-view-count[data-work-id=95273578]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273578; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273578']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273578, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a909f33b6a87c172666a0258c39316fe" } } $('.js-work-strip[data-work-id=95273578]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273578,"title":"Effect of Hydroxyethylrutosides on Hypoxial-Induced Neutrophil Adherence to Umbilical Vein Endothelium","translated_title":"","metadata":{"abstract":"A clinically available mixture of hydroxyethylrutosides (HR) was examined as a protector against endothelial cell activation by hypoxia in perfused human umbilical vein. The results showed that 500 µg/mL HR totally inhibited the adherence of human unstimulated neutrophils to the endothelium of umbilical vein incubated in hypoxic conditions. This inhibition was confirmed by a morphological study performed by scanning electron microscopy. In addition, neutrophils adherent to the hypoxic umbilical vein endothelium became activated, as evidenced by the increased release of superoxide anions and synthesis of leukotriene B4. These processes could also be inhibited by HR. In conclusion, the results of this study suggest that the improvement in venous insufficiency observed clinically with HR could, in part, be the result of their ability to inhibit the recruitment and activation of neutrophils by endothelium activated during blood stasis.","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"Cardiovascular Drugs and Therapy - CARDIOVASC DRUG THERAPY"},"translated_abstract":"A clinically available mixture of hydroxyethylrutosides (HR) was examined as a protector against endothelial cell activation by hypoxia in perfused human umbilical vein. The results showed that 500 µg/mL HR totally inhibited the adherence of human unstimulated neutrophils to the endothelium of umbilical vein incubated in hypoxic conditions. This inhibition was confirmed by a morphological study performed by scanning electron microscopy. In addition, neutrophils adherent to the hypoxic umbilical vein endothelium became activated, as evidenced by the increased release of superoxide anions and synthesis of leukotriene B4. These processes could also be inhibited by HR. In conclusion, the results of this study suggest that the improvement in venous insufficiency observed clinically with HR could, in part, be the result of their ability to inhibit the recruitment and activation of neutrophils by endothelium activated during blood stasis.","internal_url":"https://www.academia.edu/95273578/Effect_of_Hydroxyethylrutosides_on_Hypoxial_Induced_Neutrophil_Adherence_to_Umbilical_Vein_Endothelium","translated_internal_url":"","created_at":"2023-01-18T22:56:00.127-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33692092,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97500468,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500468/thumbnails/1.jpg","file_name":"A_1007772817842.pdf","download_url":"https://www.academia.edu/attachments/97500468/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effect_of_Hydroxyethylrutosides_on_Hypox.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500468/A_1007772817842-libre.pdf?1674114574=\u0026response-content-disposition=attachment%3B+filename%3DEffect_of_Hydroxyethylrutosides_on_Hypox.pdf\u0026Expires=1732731799\u0026Signature=P5JS9XAvBX3JEE67x~x4fLileXRqvjh2qc4WEHuHi82c3zLBEt~~Q-KYHXyT9JQGzFESaouqbb4R6Q8UKWzypwAYlkhcoWn0Wu2isExefyuoS4U~JlSawa00W-4k0gBdbKHWJF~z50gAV7QnqVFua61ItcoodLJypLglWPAV59SH7pb7OEHgO0jhTrbHGgoYmDN7GIyATquiRK-DddcRkRzOaLtbPmKfkEHmFsgvx8DaIbisvXN7bd-mw0LYn~tapiawJjOZ3fhWK69v4BY8VIlQNINRTRBlQVIiKNgjXJ9UPDZeIUzqUYF0hv42kmYENfGIGjCXvlI5PPd2xLID5A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Effect_of_Hydroxyethylrutosides_on_Hypoxial_Induced_Neutrophil_Adherence_to_Umbilical_Vein_Endothelium","translated_slug":"","page_count":2,"language":"en","content_type":"Work","owner":{"id":33692092,"first_name":"Carine","middle_initials":null,"last_name":"Michiels","page_name":"CarineMichiels","domain_name":"lambiotte","created_at":"2015-08-06T23:03:11.643-07:00","display_name":"Carine 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sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":28192827,"url":"http://www.springerlink.com/content/w10r06lh5200435v"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95273577"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273577/Chemical_reactivity_of_plasma_polymerized_allylamine_PPAA_thin_films_on_Au_and_Si_Study_of_the_thickness_influence_and_aging_of_the_films"><img alt="Research paper thumbnail of Chemical reactivity of plasma polymerized allylamine (PPAA) thin films on Au and Si: Study of the thickness influence and aging of the films" class="work-thumbnail" src="https://attachments.academia-assets.com/97500467/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273577/Chemical_reactivity_of_plasma_polymerized_allylamine_PPAA_thin_films_on_Au_and_Si_Study_of_the_thickness_influence_and_aging_of_the_films">Chemical reactivity of plasma polymerized allylamine (PPAA) thin films on Au and Si: Study of the thickness influence and aging of the films</a></div><div class="wp-workCard_item"><span>Surface and Coatings Technology</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ae9f98d09d0352e6df2eaed9fb8c2864" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" 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waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ae9f98d09d0352e6df2eaed9fb8c2864" } } $('.js-work-strip[data-work-id=95273577]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273577,"title":"Chemical reactivity of plasma polymerized allylamine (PPAA) thin films on Au and Si: Study of the thickness influence and aging of the films","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"In this work, we investigate the surface reactivity of substrates coated with thin layers (estimated thickness ≤ 30 nm) of plasma polymerized allylamine films (PPAA), an amine-functionalized polymer deposited by plasma-enhanced chemical vapor deposition (PECVD) with radiofrequency (RF) discharges. Our results show that very thin layers, or islands, can retain on their surface molecules that are able to react through their NH 2 functions. We have tested and assessed by X-Ray Electron Spectroscopy (XPS) and Quartz Crystal Microbalance (QCM) the surface density of chemical functions vs. layer thicknesses by using chemical derivatization with two types of agents: imine formation by a reaction of primary amine from the coating with aldehyde (Pentafluorobenzaldehyde, PFBA) and amide-bond formation by reaction with an activated carboxylic group (Succinimidyl Succinate Terminated Polyethylene glycol, EGSS). Results show that the PPAA coatings-even for very thin layers of a few nanometers-promote the chemisorption of the tagging molecules. The aging under air and evolution of reactive amine surface concentration with time under air are also presented.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Surface and Coatings Technology","grobid_abstract_attachment_id":97500467},"translated_abstract":null,"internal_url":"https://www.academia.edu/95273577/Chemical_reactivity_of_plasma_polymerized_allylamine_PPAA_thin_films_on_Au_and_Si_Study_of_the_thickness_influence_and_aging_of_the_films","translated_internal_url":"","created_at":"2023-01-18T22:56:00.022-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33692092,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97500467,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500467/thumbnails/1.jpg","file_name":"moreau2011.pdf","download_url":"https://www.academia.edu/attachments/97500467/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Chemical_reactivity_of_plasma_polymerize.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500467/moreau2011.pdf?1674111421=\u0026response-content-disposition=attachment%3B+filename%3DChemical_reactivity_of_plasma_polymerize.pdf\u0026Expires=1732731799\u0026Signature=RX21hqe1svSsM7pAhblVwjFx-tBd3MyfPXwfPfVX-BlOtukUNJYugFvXQFgB-6AnZvxOudZgOIu3yiWcFx7yOmLYotrMO6~d5F2CHWgaJToycltSz99W8vX2~ngGmSzjhm~RstYio06Gxv0NvsgugIwNjQcZIeNC4S~BEKedeDWGPta9RihqFyHrWGqJVJMa5tlww5uR5Q3zNN0k9biEXT2u48BjYLZuwjx9G6FLcRvm0EUBBtLx7UnKQBPkQVLXKn~g9HOJbiv2z2Zh-dkUk2dcYjg7kDO6oFnByqQRJrngKSUzh6oaOKETxXnxUupz5TCKqMiWLXm9Pm9b~9IKJw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Chemical_reactivity_of_plasma_polymerized_allylamine_PPAA_thin_films_on_Au_and_Si_Study_of_the_thickness_influence_and_aging_of_the_films","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":33692092,"first_name":"Carine","middle_initials":null,"last_name":"Michiels","page_name":"CarineMichiels","domain_name":"lambiotte","created_at":"2015-08-06T23:03:11.643-07:00","display_name":"Carine 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biological tissues to break or modify the DNA, which is the molecule contained in the nuclei of cells that carries all the relevant information for the organism. As such, radiation is dangerous for individuals; however, its properties can also be used in medicine, e. g. in cancer treatments. Nevertheless, the exact mechanisms of cellular response to radiation are not fully understood yet, especially for low doses (below 50 cGy), where non-targeted effects, i. e. that do not involve only the interactions radiation-DNA, are taking place. In order to deepen the knowledge of those non-targeted effects, a computer model of a population of cells irradiated in vitro was written, taking into account the phenomena in the low dose domain. \" Liliana, for the afternoon tea times, and chats about life, boyfriends, supervisor and occasionally, scientific issues;. Many others: Kevin Prise, Mick Woodcock and Giuseppe Schettino for the scientific advice, Raj and Marie-Laure for the moral support, Giselle, Joshua, Guillermo, Alicia, Graham and the Oxfam team and St John's homegroup... who have made my life easier in one way or another. 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});</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273574, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "953a6dc1323a380782cfdacbf5d2566a" } } $('.js-work-strip[data-work-id=95273574]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273574,"title":"Low-LET Proton Irradiation of A549 Non-small Cell Lung Adenocarcinoma Cells: Dose Response and RBE Determination","translated_title":"","metadata":{"publisher":"Radiation Research Society","grobid_abstract":"Since 1957, broad proton beam radiotherapy with a spread out Bragg peak has been used for cancer treatment. More recently, studies on the use of proton therapy in the treatment of nonsmall-cell lung cancer (NSCLC) were performed and, although the benefit of using protons for the treatment of NSCLC is recognized, more work is needed to gather additional data for the understanding of cell response. Human A549 cell survival was evaluated by colony forming assay 11 days after 10 keV/µm proton beam irradiation at 0.1 and 1 Gy/min. The residual energy of the proton beam at the location of the irradiated cells was 3.9 MeV. In parallel, early effects on the cell viability and DNA damage were assessed and DNA synthesis was measured. The survival curve obtained was fitted with both the Linear and the Induced-Repair models as a hyper-radiosensitivity was evidenced at very low doses. Above 0.5 Gy, a linear shape was observed with the  parameter equal to 0.824 ± 0.029 Gy-1. Early cell death and cell proliferation arrest were highlighted. Moreover, a clear correlation between DNA damage and surviving fraction was observed. Finally, comparisons with X results indicate that proton irradiation at 10 keV/µm enhances the tumor radiosensitivity with a significant dose-dependent decrease in the survival fraction. The RBE value of 1.9 ± 0.4 obtained for a 10% survival supports this observation. This is the first study to show that low LET proton irradiation of lung cancer cells evidenced hyper-radiosensitivity with a high RBE value.","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Radiation Research","grobid_abstract_attachment_id":97500469},"translated_abstract":null,"internal_url":"https://www.academia.edu/95273574/Low_LET_Proton_Irradiation_of_A549_Non_small_Cell_Lung_Adenocarcinoma_Cells_Dose_Response_and_RBE_Determination","translated_internal_url":"","created_at":"2023-01-18T22:55:59.711-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33692092,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97500469,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500469/thumbnails/1.jpg","file_name":"W_ra_proton.pdf","download_url":"https://www.academia.edu/attachments/97500469/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Low_LET_Proton_Irradiation_of_A549_Non_s.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500469/W_ra_proton-libre.pdf?1674114580=\u0026response-content-disposition=attachment%3B+filename%3DLow_LET_Proton_Irradiation_of_A549_Non_s.pdf\u0026Expires=1732731799\u0026Signature=Y4wkJV1fhdZNfyyoBGVZwKnUUW-fv00D7He81PEdjUnNAaHAtu6-Dc8uyBx4m66kqEDC169vQ4NFb-79jxAbnIIPoXa7LFIwABxRXD-4XjDwGuNZsd30gFOlnGYUgq~k~YI93LEhKvKeiVosVEgLy2fA4qR9O0MuC49Db-qJZIqkBQLO7QmgkeX~MwtY~mc7aGer5jYgVVuPuNRB2DlVlK1st8caTDZKmggt17HNv6qlAFjr7pxb7cissDrtYd49SFF3e-CLIvEeZW5K3YfmsIfGHal9EHfzleM48041n682xRHY1iRPNZsr6KtoSDvokqT3L1S8wXp1oJdqFOot6g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Low_LET_Proton_Irradiation_of_A549_Non_small_Cell_Lung_Adenocarcinoma_Cells_Dose_Response_and_RBE_Determination","translated_slug":"","page_count":34,"language":"en","content_type":"Work","owner":{"id":33692092,"first_name":"Carine","middle_initials":null,"last_name":"Michiels","page_name":"CarineMichiels","domain_name":"lambiotte","created_at":"2015-08-06T23:03:11.643-07:00","display_name":"Carine Michiels","url":"https://lambiotte.academia.edu/CarineMichiels"},"attachments":[{"id":97500469,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500469/thumbnails/1.jpg","file_name":"W_ra_proton.pdf","download_url":"https://www.academia.edu/attachments/97500469/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Low_LET_Proton_Irradiation_of_A549_Non_s.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500469/W_ra_proton-libre.pdf?1674114580=\u0026response-content-disposition=attachment%3B+filename%3DLow_LET_Proton_Irradiation_of_A549_Non_s.pdf\u0026Expires=1732731799\u0026Signature=Y4wkJV1fhdZNfyyoBGVZwKnUUW-fv00D7He81PEdjUnNAaHAtu6-Dc8uyBx4m66kqEDC169vQ4NFb-79jxAbnIIPoXa7LFIwABxRXD-4XjDwGuNZsd30gFOlnGYUgq~k~YI93LEhKvKeiVosVEgLy2fA4qR9O0MuC49Db-qJZIqkBQLO7QmgkeX~MwtY~mc7aGer5jYgVVuPuNRB2DlVlK1st8caTDZKmggt17HNv6qlAFjr7pxb7cissDrtYd49SFF3e-CLIvEeZW5K3YfmsIfGHal9EHfzleM48041n682xRHY1iRPNZsr6KtoSDvokqT3L1S8wXp1oJdqFOot6g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":1328,"name":"Radiation","url":"https://www.academia.edu/Documents/in/Radiation"},{"id":10030,"name":"Radiation Therapy","url":"https://www.academia.edu/Documents/in/Radiation_Therapy"},{"id":10035,"name":"Nuclear medicine","url":"https://www.academia.edu/Documents/in/Nuclear_medicine"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":118582,"name":"Physical sciences","url":"https://www.academia.edu/Documents/in/Physical_sciences"},{"id":439023,"name":"Irradiation","url":"https://www.academia.edu/Documents/in/Irradiation"},{"id":562564,"name":"Proton","url":"https://www.academia.edu/Documents/in/Proton"},{"id":832191,"name":"Relative Biological Effectiveness","url":"https://www.academia.edu/Documents/in/Relative_Biological_Effectiveness"},{"id":879919,"name":"Radiosensitivity","url":"https://www.academia.edu/Documents/in/Radiosensitivity"},{"id":1208793,"name":"Protons","url":"https://www.academia.edu/Documents/in/Protons"},{"id":1745478,"name":"Adenocarcinoma","url":"https://www.academia.edu/Documents/in/Adenocarcinoma"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"},{"id":3840853,"name":"lung neoplasms","url":"https://www.academia.edu/Documents/in/lung_neoplasms"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95273573"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273573/89Zr_labeled_anti_endoglin_antibody_targeted_gold_nanoparticles_for_imaging_cancer_implications_for_future_cancer_therapy"><img alt="Research paper thumbnail of 89Zr-labeled anti-endoglin antibody-targeted gold nanoparticles for imaging cancer: implications for future cancer therapy" class="work-thumbnail" src="https://attachments.academia-assets.com/97500496/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273573/89Zr_labeled_anti_endoglin_antibody_targeted_gold_nanoparticles_for_imaging_cancer_implications_for_future_cancer_therapy">89Zr-labeled anti-endoglin antibody-targeted gold nanoparticles for imaging cancer: implications for future cancer therapy</a></div><div class="wp-workCard_item"><span>Nanomedicine</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aims: Antibody-labeled gold nanoparticles represent an attractive tool for cancer imaging and the...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aims: Antibody-labeled gold nanoparticles represent an attractive tool for cancer imaging and therapy. In this study, the anti-CD105 antibody was conjugated with gold nanoparticles (AuNPs) for the first time. The antibody biodistribution in mice before and after conjugation to AuNPs was studied, with a focus on tumor targeting. Materials & methods: Antibodies were radiolabeled with 89Zr before conjugation to AuNPs (5 nm). Immunonanoconjugates were characterized in vitro in terms of size, stability in plasma and binding to the target. Quantitative PET imaging and ICP-MS analysis assessed in vivo distribution and specific tumor targeting of tracers. Results: The tumor uptake of immunoconjugates was preserved up to 24 h after injection, with high tumor contrast and selective tumor targeting. No major tracer accumulation was observed over time in nonspecific organs. ICP-MS analysis confirmed the antibody specificity after nanoparticle conjugation. Conclusion: The anti-CD105 antibody con...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="93b3b38d01e2cdfca221f8a2d2a72948" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500496,"asset_id":95273573,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500496/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273573"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273573"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273573; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273573]").text(description); $(".js-view-count[data-work-id=95273573]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273573; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273573']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273573, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "93b3b38d01e2cdfca221f8a2d2a72948" } } $('.js-work-strip[data-work-id=95273573]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273573,"title":"89Zr-labeled anti-endoglin antibody-targeted gold nanoparticles for imaging cancer: implications for future cancer therapy","translated_title":"","metadata":{"abstract":"Aims: Antibody-labeled gold nanoparticles represent an attractive tool for cancer imaging and therapy. In this study, the anti-CD105 antibody was conjugated with gold nanoparticles (AuNPs) for the first time. The antibody biodistribution in mice before and after conjugation to AuNPs was studied, with a focus on tumor targeting. Materials \u0026 methods: Antibodies were radiolabeled with 89Zr before conjugation to AuNPs (5 nm). Immunonanoconjugates were characterized in vitro in terms of size, stability in plasma and binding to the target. Quantitative PET imaging and ICP-MS analysis assessed in vivo distribution and specific tumor targeting of tracers. Results: The tumor uptake of immunoconjugates was preserved up to 24 h after injection, with high tumor contrast and selective tumor targeting. No major tracer accumulation was observed over time in nonspecific organs. ICP-MS analysis confirmed the antibody specificity after nanoparticle conjugation. Conclusion: The anti-CD105 antibody con...","publisher":"Future Medicine Ltd","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Nanomedicine"},"translated_abstract":"Aims: Antibody-labeled gold nanoparticles represent an attractive tool for cancer imaging and therapy. In this study, the anti-CD105 antibody was conjugated with gold nanoparticles (AuNPs) for the first time. The antibody biodistribution in mice before and after conjugation to AuNPs was studied, with a focus on tumor targeting. Materials \u0026 methods: Antibodies were radiolabeled with 89Zr before conjugation to AuNPs (5 nm). Immunonanoconjugates were characterized in vitro in terms of size, stability in plasma and binding to the target. Quantitative PET imaging and ICP-MS analysis assessed in vivo distribution and specific tumor targeting of tracers. Results: The tumor uptake of immunoconjugates was preserved up to 24 h after injection, with high tumor contrast and selective tumor targeting. No major tracer accumulation was observed over time in nonspecific organs. ICP-MS analysis confirmed the antibody specificity after nanoparticle conjugation. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95273571"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273571/Hypoxia_induces_protection_against_etoposide_induced_apoptosis_molecular_profiling_of_changes_in_gene_expression_and_transcription_factor_activity"><img alt="Research paper thumbnail of Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity" class="work-thumbnail" src="https://attachments.academia-assets.com/97500431/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273571/Hypoxia_induces_protection_against_etoposide_induced_apoptosis_molecular_profiling_of_changes_in_gene_expression_and_transcription_factor_activity">Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity</a></div><div class="wp-workCard_item"><span>Molecular Cancer</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background it is now well established that hypoxia renders tumor cells resistant to radio- but al...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background it is now well established that hypoxia renders tumor cells resistant to radio- but also chemotherapy. However, few elements are currently available as for the mechanisms underlying this protection. Results in this study, physiological hypoxia was shown to inhibit apoptosis induced in HepG2 cells by etoposide. Indeed, hypoxia reduced DNA fragmentation, caspase activation and PARP cleavage. The DNA binding activity of 10 transcription factors was followed while the actual transcriptional activity was measured using specific reporter plasmids. Of note is the inhibition of the etoposide-induced activation of p53 under hypoxia. In parallel, data from low density DNA microarrays indicate that the expression of several pro- and anti-apoptotic genes was modified, among which are Bax and Bak whose expression profile paralleled p53 activity. Cluster analysis of data unravels several possible pathways involved in the hypoxia-induced protection against etoposide-induced apoptosis: o...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cb4aeb29afc6dec425d4d8ff719e2c0c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500431,"asset_id":95273571,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500431/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273571"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273571"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273571; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273571]").text(description); $(".js-view-count[data-work-id=95273571]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273571; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273571']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273571, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cb4aeb29afc6dec425d4d8ff719e2c0c" } } $('.js-work-strip[data-work-id=95273571]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273571,"title":"Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity","translated_title":"","metadata":{"abstract":"Background it is now well established that hypoxia renders tumor cells resistant to radio- but also chemotherapy. 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data-work-id="95273570"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273570/Erratum_to_Caspase_activation_precedes_PTP_opening_in_TNF_%CE%B1_induced_apoptosis_in_L929_cells_Mitochondrion_3_2004_261_278_"><img alt="Research paper thumbnail of Erratum to “Caspase activation precedes PTP opening in TNF-α-induced apoptosis in L929 cells” [Mitochondrion 3 (2004) 261–278]" class="work-thumbnail" src="https://attachments.academia-assets.com/97500472/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273570/Erratum_to_Caspase_activation_precedes_PTP_opening_in_TNF_%CE%B1_induced_apoptosis_in_L929_cells_Mitochondrion_3_2004_261_278_">Erratum to “Caspase activation precedes PTP opening in TNF-α-induced apoptosis in L929 cells” [Mitochondrion 3 (2004) 261–278]</a></div><div class="wp-workCard_item"><span>Mitochondrion</span><span>, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="082996b6496d8a0f80cda8834d4fb25f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500472,"asset_id":95273570,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500472/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273570"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i 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$('.js-work-strip[data-work-id=95273570]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273570,"title":"Erratum to “Caspase activation precedes PTP opening in TNF-α-induced apoptosis in L929 cells” [Mitochondrion 3 (2004) 261–278]","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2005,"errors":{}},"publication_name":"Mitochondrion"},"translated_abstract":null,"internal_url":"https://www.academia.edu/95273570/Erratum_to_Caspase_activation_precedes_PTP_opening_in_TNF_%CE%B1_induced_apoptosis_in_L929_cells_Mitochondrion_3_2004_261_278_","translated_internal_url":"","created_at":"2023-01-18T22:55:59.331-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33692092,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97500472,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500472/thumbnails/1.jpg","file_name":"j.mito.2005.01.00120230119-1-hjb7s8.pdf","download_url":"https://www.academia.edu/attachments/97500472/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Erratum_to_Caspase_activation_precedes_P.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500472/j.mito.2005.01.00120230119-1-hjb7s8-libre.pdf?1674114573=\u0026response-content-disposition=attachment%3B+filename%3DErratum_to_Caspase_activation_precedes_P.pdf\u0026Expires=1732731800\u0026Signature=UE5pVq2ngYgqofrYVEyPOFDOAqsDbSFPHPfjrULbQL7p6JT~2vnNchCePCvVXOiiEJcsiB~jGwteqxkRfr1lEDxUs4BV2aCRmwVtaubl3Iq02kFuH75VzAkCIhC2KoaM9-tjfHUQmP2BNYN1kPZkEih28PdaDt-OT5RJ1ivZateF0Y6QyGMl29~tqoKjvi00ZY6SNr5IvgKhAs5J-ZjLpxRlOwqU-vkAQI38kkwyJNnJPRD9rYBSdE7RMFzg4VNL1KAxzNHgk6cN691W5OuC6sexOUkAXQNFvr-OgpMLKuFei3PqfPtn57dTxEJmYXor2XIMk0HSqkodvwA8mtPUpg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Erratum_to_Caspase_activation_precedes_PTP_opening_in_TNF_α_induced_apoptosis_in_L929_cells_Mitochondrion_3_2004_261_278_","translated_slug":"","page_count":2,"language":"en","content_type":"Work","owner":{"id":33692092,"first_name":"Carine","middle_initials":null,"last_name":"Michiels","page_name":"CarineMichiels","domain_name":"lambiotte","created_at":"2015-08-06T23:03:11.643-07:00","display_name":"Carine 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href="https://www.academia.edu/95273569/Radioimmunotherapy_with_radioactive_nanoparticles_Biological_doses_and_treatment_efficiency_for_vascularized_tumors_with_or_without_a_central_hypoxic_area"><img alt="Research paper thumbnail of Radioimmunotherapy with radioactive nanoparticles: Biological doses and treatment efficiency for vascularized tumors with or without a central hypoxic area" class="work-thumbnail" src="https://attachments.academia-assets.com/97500470/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273569/Radioimmunotherapy_with_radioactive_nanoparticles_Biological_doses_and_treatment_efficiency_for_vascularized_tumors_with_or_without_a_central_hypoxic_area">Radioimmunotherapy with radioactive nanoparticles: Biological doses and treatment efficiency for vascularized tumors with or without a central hypoxic area</a></div><div class="wp-workCard_item"><span>Medical Physics</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="16335b65e5a4dbccd955a047338dea96" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500470,"asset_id":95273569,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500470/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273569"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa 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$('.js-work-strip[data-work-id=95273569]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273569,"title":"Radioimmunotherapy with radioactive nanoparticles: Biological doses and treatment efficiency for vascularized tumors with or without a central hypoxic area","translated_title":"","metadata":{"publisher":"Wiley","grobid_abstract":"Radioactive atoms attached to monoclonal antibodies are used in radioimmunotherapy to treat cancer while limiting radiation to healthy tissues. One limitation of this method is that only one radioactive atom is linked to each antibody and the deposited dose is often insufficient to eradicate solid and radioresistant tumors. In a previous study, simulations with the Monte Carlo N-Particle eXtended code showed that physical doses up to 50 Gy can be delivered inside tumors by replacing the single radionuclide by a radioactive nanoparticle of 5 nm diameter containing hundreds of radioactive atoms. However, tumoral and normal tissues are not equally sensitive to radiation, and previous works did not take account the biological effects such as cellular repair processes or the presence of less radiosensitive cells such as hypoxic cells. Methods: The idea is to adapt the linear-quadratic expression to the tumor model and to determine biological effective doses ͑BEDs͒ delivered through and around a tumor. This BED is then incorporated into a Poisson formula to determine the shell control probability ͑SCP͒ which predicts the cell cluster-killing efficiency at different distances \"r\" from the center of the tumor. BED and SCP models are used to analyze the advantages of injecting radioactive nanoparticles instead of a single radionuclide per vector in radioimmunotherapy. Results: Calculations of BED and SCP for different distances r from the center of a solid tumor, using the non-small-cell lung cancer as an example, were investigated for 90 Y 2 O 3 nanoparticles. With a total activity of about 3.5 and 20 MBq for tumor radii of 0.5 and 1.0 cm, respectively, results show that a very high BED is deposited in the well oxygenated part of the spherical carcinoma. Conclusions: For either small or large solid tumors, BED and SCP calculations highlight the important benefit in replacing the single ␤-emitter 90 Y attached to each antibody by a 90 Y 2 O 3 nanoparticle.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Medical 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class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="3345924" id="papers"><div class="js-work-strip profile--work_container" data-work-id="95273591"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273591/Taking_Advantage_of_the_Senescence_Promoting_Effect_of_Olaparib_after_X_ray_and_Proton_Irradiation_Using_the_Senolytic_Drug_ABT_263"><img alt="Research paper thumbnail of Taking Advantage of the Senescence-Promoting Effect of Olaparib after X-ray and Proton Irradiation Using the Senolytic Drug, ABT-263" class="work-thumbnail" src="https://attachments.academia-assets.com/97500434/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273591/Taking_Advantage_of_the_Senescence_Promoting_Effect_of_Olaparib_after_X_ray_and_Proton_Irradiation_Using_the_Senolytic_Drug_ABT_263">Taking Advantage of the Senescence-Promoting Effect of Olaparib after X-ray and Proton Irradiation Using the Senolytic Drug, ABT-263</a></div><div class="wp-workCard_item"><span>Cancers</span><span>, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Radiotherapy (RT) is a key component of cancer treatment. Although improvements have been made ov...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Radiotherapy (RT) is a key component of cancer treatment. Although improvements have been made over the years, radioresistance remains a challenge. For this reason, a better understanding of cell fates in response to RT could improve therapeutic options to enhance cell death and reduce adverse effects. Here, we showed that combining RT (photons and protons) to noncytotoxic concentration of PARP inhibitor, Olaparib, induced a cell line-dependent senescence-like phenotype. The senescent cells were characterized by morphological changes, an increase in p21 mRNA expression as well as an increase in senescence-associated β-galactosidase activity. We demonstrated that these senescent cells could be specifically targeted by Navitoclax (ABT-263), a Bcl-2 family inhibitor. This senolytic drug led to significant cell death when combined with RT and Olaparib, while limited cytotoxicity was observed when used alone. These results demonstrate that a combination of RT with PARP inhibition and sen...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="009fca5db8d9558efc776ad962c7e706" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500434,"asset_id":95273591,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500434/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273591"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273591"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273591; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273591]").text(description); $(".js-view-count[data-work-id=95273591]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273591; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273591']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273591, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "009fca5db8d9558efc776ad962c7e706" } } $('.js-work-strip[data-work-id=95273591]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273591,"title":"Taking Advantage of the Senescence-Promoting Effect of Olaparib after X-ray and Proton Irradiation Using the Senolytic Drug, ABT-263","translated_title":"","metadata":{"abstract":"Radiotherapy (RT) is a key component of cancer treatment. 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These results demonstrate that a combination of RT with PARP inhibition and sen...","publisher":"MDPI AG","publication_date":{"day":null,"month":null,"year":2022,"errors":{}},"publication_name":"Cancers"},"translated_abstract":"Radiotherapy (RT) is a key component of cancer treatment. Although improvements have been made over the years, radioresistance remains a challenge. For this reason, a better understanding of cell fates in response to RT could improve therapeutic options to enhance cell death and reduce adverse effects. Here, we showed that combining RT (photons and protons) to noncytotoxic concentration of PARP inhibitor, Olaparib, induced a cell line-dependent senescence-like phenotype. The senescent cells were characterized by morphological changes, an increase in p21 mRNA expression as well as an increase in senescence-associated β-galactosidase activity. 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Confrontation between theoretical and experimental data" class="work-thumbnail" src="https://attachments.academia-assets.com/97500497/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273589/Importance_of_various_antioxidant_enzymes_for_cell_stability_Confrontation_between_theoretical_and_experimental_data">Importance of various antioxidant enzymes for cell stability. Confrontation between theoretical and experimental data</a></div><div class="wp-workCard_item"><span>Biochemical Journal</span><span>, 1992</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A theoretical model was developed taking into account the production and destruction of oxygen-de...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A theoretical model was developed taking into account the production and destruction of oxygen-derived free radicals. The steady state of the system was derived by using the rate equations of these reactions, and the stability of the system was tested. In the simplified model, only one stable steady state was found. However, we know that glutathione peroxidase can be inhibited by hydroperoxides, and, when incorporated into the model, this effect led to a complex situation with the presence of some stable and some unstable domains according to the concentration of either the enzyme or the hydroperoxide. This qualitative description of the system was compared with experimental data on the protection given by three antioxidant enzymes, and concordance of data was found which allows some quantification of the system. 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"profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95273587"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273587/Monte_Carlo_Calculation_of_Radioimmunotherapy_with90Y_177Lu_131I_124I_and188Re_Nanoobjects_Choice_of_the_Best_Radionuclide_for_Solid_Tumour_Treatment_by_Using_TCP_and_NTCP_Concepts"><img alt="Research paper thumbnail of Monte Carlo Calculation of Radioimmunotherapy with90Y-,177Lu-,131I-,124I-, and188Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts" class="work-thumbnail" src="https://attachments.academia-assets.com/97500433/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273587/Monte_Carlo_Calculation_of_Radioimmunotherapy_with90Y_177Lu_131I_124I_and188Re_Nanoobjects_Choice_of_the_Best_Radionuclide_for_Solid_Tumour_Treatment_by_Using_TCP_and_NTCP_Concepts">Monte Carlo Calculation of Radioimmunotherapy with90Y-,177Lu-,131I-,124I-, and188Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts</a></div><div class="wp-workCard_item"><span>Computational and Mathematical Methods in Medicine</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Radioimmunotherapy has shown that the use of monoclonal antibodies combined with a radioisotope l...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Radioimmunotherapy has shown that the use of monoclonal antibodies combined with a radioisotope like131I or90Y still remains ineffective for solid and radioresistant tumour treatment. Previous simulations have revealed that an increase in the number of90Y labelled to each antibody or nanoobject could be a solution to improve treatment output. It now seems important to assess the treatment output and toxicity when radionuclides such as90Y,177Lu,131I,124I, and188Re are used. Tumour control probability (TCP) and normal tissue complication probability (NTCP) curves versus the number of radionuclides per nanoobject were computed with MCNPX to evaluate treatment efficacy for solid tumours and to predict the incidence of surrounding side effects. Analyses were carried out for two solid tumour sizes of 0.5 and 1.0 cm radius and for nanoobject (i.e., a radiolabelled antibody) distributed uniformly or nonuniformly throughout a solid tumour (e.g., Non-small-cell-lung cancer (NSCLC)).90Y and188...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e9f11b7fc3479568369516e96bf50b40" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500433,"asset_id":95273587,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500433/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273587"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273587"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273587; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273587]").text(description); $(".js-view-count[data-work-id=95273587]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273587; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273587']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273587, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e9f11b7fc3479568369516e96bf50b40" } } $('.js-work-strip[data-work-id=95273587]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273587,"title":"Monte Carlo Calculation of Radioimmunotherapy with90Y-,177Lu-,131I-,124I-, and188Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts","translated_title":"","metadata":{"abstract":"Radioimmunotherapy has shown that the use of monoclonal antibodies combined with a radioisotope like131I or90Y still remains ineffective for solid and radioresistant tumour treatment. 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System" class="work-thumbnail" src="https://attachments.academia-assets.com/97500477/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273584/Effects_of_Alpha_Particle_and_Proton_Beam_Irradiation_as_Putative_Cross_Talk_between_A549_Cancer_Cells_and_the_Endothelial_Cells_in_a_Co_Culture_System">Effects of Alpha Particle and Proton Beam Irradiation as Putative Cross-Talk between A549 Cancer Cells and the Endothelial Cells in a Co-Culture System</a></div><div class="wp-workCard_item"><span>Cancers</span><span>, Jan 18, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">High-LET ion irradiation is being more and more often used to control tumors in patients. Given t...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">High-LET ion irradiation is being more and more often used to control tumors in patients. Given that tumors are now considered as complex organs composed of multiple cell types that can influence radiosensitivity, we investigated the effects of proton and alpha particle irradiation on the possible radioprotective cross-talk between cancer and endothelial cells. We designed new irradiation chambers that allow co-culture study of cells irradiated with a particle beam. A549 lung carcinoma cells and endothelial cells (EC) were exposed to 1.5 Gy of proton beam or 1 and 2 Gy of alpha particles. Cell responses were studied by clonogenic assays and cell cycle was analyzed by flow cytometry. Gene expression studies were performed using Taqman low density array and by RT-qPCR. A549 cells and EC displayed similar survival fraction and they had similar cell cycle distribution when irradiated alone or in co-culture. Both types of irradiation induced the overexpression of genes involved in cell g...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="389ab1bc5af9c89abd99402fa9f07ac7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500477,"asset_id":95273584,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500477/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273584"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273584"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273584; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273584]").text(description); $(".js-view-count[data-work-id=95273584]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273584; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273584']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273584, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "389ab1bc5af9c89abd99402fa9f07ac7" } } $('.js-work-strip[data-work-id=95273584]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273584,"title":"Effects of Alpha Particle and Proton Beam Irradiation as Putative Cross-Talk between A549 Cancer Cells and the Endothelial Cells in a Co-Culture System","translated_title":"","metadata":{"abstract":"High-LET ion irradiation is being more and more often used to control tumors in patients. Given that tumors are now considered as complex organs composed of multiple cell types that can influence radiosensitivity, we investigated the effects of proton and alpha particle irradiation on the possible radioprotective cross-talk between cancer and endothelial cells. We designed new irradiation chambers that allow co-culture study of cells irradiated with a particle beam. A549 lung carcinoma cells and endothelial cells (EC) were exposed to 1.5 Gy of proton beam or 1 and 2 Gy of alpha particles. Cell responses were studied by clonogenic assays and cell cycle was analyzed by flow cytometry. Gene expression studies were performed using Taqman low density array and by RT-qPCR. A549 cells and EC displayed similar survival fraction and they had similar cell cycle distribution when irradiated alone or in co-culture. Both types of irradiation induced the overexpression of genes involved in cell g...","publication_date":{"day":18,"month":1,"year":2015,"errors":{}},"publication_name":"Cancers"},"translated_abstract":"High-LET ion irradiation is being more and more often used to control tumors in patients. Given that tumors are now considered as complex organs composed of multiple cell types that can influence radiosensitivity, we investigated the effects of proton and alpha particle irradiation on the possible radioprotective cross-talk between cancer and endothelial cells. We designed new irradiation chambers that allow co-culture study of cells irradiated with a particle beam. A549 lung carcinoma cells and endothelial cells (EC) were exposed to 1.5 Gy of proton beam or 1 and 2 Gy of alpha particles. Cell responses were studied by clonogenic assays and cell cycle was analyzed by flow cytometry. Gene expression studies were performed using Taqman low density array and by RT-qPCR. A549 cells and EC displayed similar survival fraction and they had similar cell cycle distribution when irradiated alone or in co-culture. Both types of irradiation induced the overexpression of genes involved in cell g...","internal_url":"https://www.academia.edu/95273584/Effects_of_Alpha_Particle_and_Proton_Beam_Irradiation_as_Putative_Cross_Talk_between_A549_Cancer_Cells_and_the_Endothelial_Cells_in_a_Co_Culture_System","translated_internal_url":"","created_at":"2023-01-18T22:56:01.051-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33692092,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97500477,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500477/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/97500477/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effects_of_Alpha_Particle_and_Proton_Bea.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500477/pdf-libre.pdf?1674114592=\u0026response-content-disposition=attachment%3B+filename%3DEffects_of_Alpha_Particle_and_Proton_Bea.pdf\u0026Expires=1732731799\u0026Signature=evzeN-Qd8CdM8sIGA2nJeSjkT1thtjl8Vauh1LGZsgA6Jb5WoB-g2B3O08iWRE3uuUIme9EFfNF6sWyEfZirc1K3CN2VEaY8PWUKfuN7s135a~wnf27zAFKwjWOU0z4Gi0HC92zug0mE026-g11J2~1DbML-V0drUcHgr1OKVUbtmDxvfUVlNLac-xrWxb3v2foh640j~NCJb8gOR~8hvjb~Ojss1lIdMGj6103YImfwk43VEDPvnqN1qdb1W2PWcevl6O7JJeX6tNv3WwlnY3849e2Xsx3a3X0TpLhFV8N62y13Urq-0~P9R-M1Yq6bZ3adaUuNUpwKAKMcpTDYGw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Effects_of_Alpha_Particle_and_Proton_Beam_Irradiation_as_Putative_Cross_Talk_between_A549_Cancer_Cells_and_the_Endothelial_Cells_in_a_Co_Culture_System","translated_slug":"","page_count":22,"language":"en","content_type":"Work","owner":{"id":33692092,"first_name":"Carine","middle_initials":null,"last_name":"Michiels","page_name":"CarineMichiels","domain_name":"lambiotte","created_at":"2015-08-06T23:03:11.643-07:00","display_name":"Carine Michiels","url":"https://lambiotte.academia.edu/CarineMichiels"},"attachments":[{"id":97500477,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500477/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/97500477/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effects_of_Alpha_Particle_and_Proton_Bea.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500477/pdf-libre.pdf?1674114592=\u0026response-content-disposition=attachment%3B+filename%3DEffects_of_Alpha_Particle_and_Proton_Bea.pdf\u0026Expires=1732731799\u0026Signature=evzeN-Qd8CdM8sIGA2nJeSjkT1thtjl8Vauh1LGZsgA6Jb5WoB-g2B3O08iWRE3uuUIme9EFfNF6sWyEfZirc1K3CN2VEaY8PWUKfuN7s135a~wnf27zAFKwjWOU0z4Gi0HC92zug0mE026-g11J2~1DbML-V0drUcHgr1OKVUbtmDxvfUVlNLac-xrWxb3v2foh640j~NCJb8gOR~8hvjb~Ojss1lIdMGj6103YImfwk43VEDPvnqN1qdb1W2PWcevl6O7JJeX6tNv3WwlnY3849e2Xsx3a3X0TpLhFV8N62y13Urq-0~P9R-M1Yq6bZ3adaUuNUpwKAKMcpTDYGw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":9113,"name":"Cell Cycle","url":"https://www.academia.edu/Documents/in/Cell_Cycle"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":37782,"name":"Cell Culture","url":"https://www.academia.edu/Documents/in/Cell_Culture"},{"id":71510,"name":"Endothelial Cells","url":"https://www.academia.edu/Documents/in/Endothelial_Cells"},{"id":72265,"name":"Hadrontherapy","url":"https://www.academia.edu/Documents/in/Hadrontherapy"},{"id":132620,"name":"Radiobiology","url":"https://www.academia.edu/Documents/in/Radiobiology"},{"id":439023,"name":"Irradiation","url":"https://www.academia.edu/Documents/in/Irradiation"},{"id":452367,"name":"Crosstalk","url":"https://www.academia.edu/Documents/in/Crosstalk"},{"id":764243,"name":"Radioresistance","url":"https://www.academia.edu/Documents/in/Radioresistance"},{"id":879919,"name":"Radiosensitivity","url":"https://www.academia.edu/Documents/in/Radiosensitivity"},{"id":1010893,"name":"Cancers","url":"https://www.academia.edu/Documents/in/Cancers"},{"id":1244098,"name":"Clonogenic Assay","url":"https://www.academia.edu/Documents/in/Clonogenic_Assay"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95273582"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273582/Heat_Modified_Citrus_Pectin_Induces_Apoptosis_Like_Cell_Death_and_Autophagy_in_HepG2_and_A549_Cancer_Cells"><img alt="Research paper thumbnail of Heat-Modified Citrus Pectin Induces Apoptosis-Like Cell Death and Autophagy in HepG2 and A549 Cancer Cells" class="work-thumbnail" src="https://attachments.academia-assets.com/97500495/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273582/Heat_Modified_Citrus_Pectin_Induces_Apoptosis_Like_Cell_Death_and_Autophagy_in_HepG2_and_A549_Cancer_Cells">Heat-Modified Citrus Pectin Induces Apoptosis-Like Cell Death and Autophagy in HepG2 and A549 Cancer Cells</a></div><div class="wp-workCard_item"><span>PLOS ONE</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5e603fbe03faaa0d8980be6dc9d632da" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500495,"asset_id":95273582,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500495/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273582"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273582"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273582; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273582]").text(description); $(".js-view-count[data-work-id=95273582]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273582; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273582']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273582, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5e603fbe03faaa0d8980be6dc9d632da" } } $('.js-work-strip[data-work-id=95273582]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273582,"title":"Heat-Modified Citrus Pectin Induces Apoptosis-Like Cell Death and Autophagy in HepG2 and A549 Cancer Cells","translated_title":"","metadata":{"publisher":"Public Library of Science (PLoS)","grobid_abstract":"Cancer is still one of the leading causes of death worldwide, and finding new treatments remains a major challenge. Previous studies showed that modified forms of pectin, a complex polysaccharide present in the primary plant cell wall, possess anticancer properties. Nevertheless, the mechanism of action of modified pectin and the pathways involved are unclear. Here, we show that citrus pectin modified by heat treatment induced cell death in HepG2 and A549 cells. The induced cell death differs from classical apoptosis because no DNA cleavage was observed. In addition, Z-VAD-fmk, a pan-caspase inhibitor, did not influence the observed cell death in HepG2 cells but appeared to be partly protective in A549 cells, indicating that heat-modified citrus pectin might induce caspase-independent cell death. An increase in the abundance of the phosphatidylethanolamine-conjugated Light Chain 3 (LC3) protein and a decrease in p62 protein abundance were observed in both cell types when incubated in the presence of heat-modified citrus pectin. These results indicate the activation of autophagy. To our knowledge, this is the first time that autophagy has been revealed in cells incubated in the presence of a modified form of pectin. This autophagy activation appears to be protective, at least for A549 cells, because its inhibition with 3-methyladenine increased the observed modified pectin-induced cytotoxicity. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95273581"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273581/A_new_experimental_model_to_study_oxygen_toxicity"><img alt="Research paper thumbnail of A new experimental model to study oxygen toxicity" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273581/A_new_experimental_model_to_study_oxygen_toxicity">A new experimental model to study oxygen toxicity</a></div><div class="wp-workCard_item"><span>Archives internationales de physiologie et de biochimie</span><span>, 1986</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">An experimental model was developed in order to study the protective effect of antioxidant molecu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">An experimental model was developed in order to study the protective effect of antioxidant molecules. Human diploid WI-38 fibroblasts were cultivated under 2 atm of 95% O2. Antioxidants like alpha-tocopherol or superoxide dismutase (SOD) were added respectively in the culture medium or directly inside the cell through a microinjection technique. With both antioxidant molecules a protection was observed. In the control experiment, cells died within 6 or 8 days depending on the confluency and the malonaldehyde content increased sharply. This model represents a new tool in order to test other antioxidant systems towards an oxidative stress.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273581"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273581"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273581; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273581]").text(description); $(".js-view-count[data-work-id=95273581]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273581; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273581']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273581, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=95273581]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273581,"title":"A new experimental model to study oxygen toxicity","translated_title":"","metadata":{"abstract":"An experimental model was developed in order to study the protective effect of antioxidant molecules. Human diploid WI-38 fibroblasts were cultivated under 2 atm of 95% O2. Antioxidants like alpha-tocopherol or superoxide dismutase (SOD) were added respectively in the culture medium or directly inside the cell through a microinjection technique. With both antioxidant molecules a protection was observed. In the control experiment, cells died within 6 or 8 days depending on the confluency and the malonaldehyde content increased sharply. This model represents a new tool in order to test other antioxidant systems towards an oxidative stress.","publication_date":{"day":null,"month":null,"year":1986,"errors":{}},"publication_name":"Archives internationales de physiologie et de biochimie"},"translated_abstract":"An experimental model was developed in order to study the protective effect of antioxidant molecules. Human diploid WI-38 fibroblasts were cultivated under 2 atm of 95% O2. Antioxidants like alpha-tocopherol or superoxide dismutase (SOD) were added respectively in the culture medium or directly inside the cell through a microinjection technique. With both antioxidant molecules a protection was observed. In the control experiment, cells died within 6 or 8 days depending on the confluency and the malonaldehyde content increased sharply. This model represents a new tool in order to test other antioxidant systems towards an oxidative stress.","internal_url":"https://www.academia.edu/95273581/A_new_experimental_model_to_study_oxygen_toxicity","translated_internal_url":"","created_at":"2023-01-18T22:56:00.812-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33692092,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"A_new_experimental_model_to_study_oxygen_toxicity","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":33692092,"first_name":"Carine","middle_initials":null,"last_name":"Michiels","page_name":"CarineMichiels","domain_name":"lambiotte","created_at":"2015-08-06T23:03:11.643-07:00","display_name":"Carine Michiels","url":"https://lambiotte.academia.edu/CarineMichiels"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":14292,"name":"Oxidative Stress","url":"https://www.academia.edu/Documents/in/Oxidative_Stress"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51711,"name":"Antioxidants","url":"https://www.academia.edu/Documents/in/Antioxidants"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":103339,"name":"Antioxidant","url":"https://www.academia.edu/Documents/in/Antioxidant"},{"id":156734,"name":"Vitamin E","url":"https://www.academia.edu/Documents/in/Vitamin_E"},{"id":212467,"name":"Microinjection","url":"https://www.academia.edu/Documents/in/Microinjection"},{"id":213343,"name":"Superoxide Dismutase","url":"https://www.academia.edu/Documents/in/Superoxide_Dismutase"},{"id":380825,"name":"Oxygen","url":"https://www.academia.edu/Documents/in/Oxygen"},{"id":418942,"name":"Oxygen Toxicity","url":"https://www.academia.edu/Documents/in/Oxygen_Toxicity"},{"id":2533047,"name":"fibroblasts","url":"https://www.academia.edu/Documents/in/fibroblasts"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95273580"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273580/Taxol_induced_Unfolded_Protein_Response_activation_in_breast_cancer_cells_exposed_to_hypoxia_ATF4_activation_regulates_autophagy_and_inhibits_apoptosis"><img alt="Research paper thumbnail of Taxol-induced Unfolded Protein Response activation in breast cancer cells exposed to hypoxia: ATF4 activation regulates autophagy and inhibits apoptosis" class="work-thumbnail" src="https://attachments.academia-assets.com/97500471/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273580/Taxol_induced_Unfolded_Protein_Response_activation_in_breast_cancer_cells_exposed_to_hypoxia_ATF4_activation_regulates_autophagy_and_inhibits_apoptosis">Taxol-induced Unfolded Protein Response activation in breast cancer cells exposed to hypoxia: ATF4 activation regulates autophagy and inhibits apoptosis</a></div><div class="wp-workCard_item"><span>The international journal of biochemistry & cell biology</span><span>, Jan 24, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Understanding the mechanisms responsible for the resistance against chemotherapy-induced cell dea...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Understanding the mechanisms responsible for the resistance against chemotherapy-induced cell death is still of great interest since the number of patients with cancer increases and relapse is commonly observed. Indeed, the development of hypoxic regions as well as UPR (unfolded protein response) activation are known to promote cancer cell adaptive responses to the stressful tumor microenvironment and resistance against anti-cancer therapies. Therefore, the impact of UPR combined to hypoxia on autophagy and apoptosis activation during taxol exposure was investigated in MDA-MB-231 and T47D breast cancer cells. The results showed that taxol rapidly induced UPR activation and that hypoxia modulated taxol-induced UPR activation differently according to the different UPR pathways (PERK, ATF6 and IRE1α). The putative involvement of these signalling pathways in autophagy or in apoptosis regulation in response to taxol exposure was investigated. However, while no link between the activation...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9220b483e16c2a61c9db832e9e430753" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500471,"asset_id":95273580,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500471/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273580"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273580"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273580; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273580]").text(description); $(".js-view-count[data-work-id=95273580]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273580; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273580']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273580, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9220b483e16c2a61c9db832e9e430753" } } $('.js-work-strip[data-work-id=95273580]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273580,"title":"Taxol-induced Unfolded Protein Response activation in breast cancer cells exposed to hypoxia: ATF4 activation regulates autophagy and inhibits apoptosis","translated_title":"","metadata":{"abstract":"Understanding the mechanisms responsible for the resistance against chemotherapy-induced cell death is still of great interest since the number of patients with cancer increases and relapse is commonly observed. Indeed, the development of hypoxic regions as well as UPR (unfolded protein response) activation are known to promote cancer cell adaptive responses to the stressful tumor microenvironment and resistance against anti-cancer therapies. Therefore, the impact of UPR combined to hypoxia on autophagy and apoptosis activation during taxol exposure was investigated in MDA-MB-231 and T47D breast cancer cells. The results showed that taxol rapidly induced UPR activation and that hypoxia modulated taxol-induced UPR activation differently according to the different UPR pathways (PERK, ATF6 and IRE1α). The putative involvement of these signalling pathways in autophagy or in apoptosis regulation in response to taxol exposure was investigated. However, while no link between the activation...","publication_date":{"day":24,"month":1,"year":2015,"errors":{}},"publication_name":"The international journal of biochemistry \u0026 cell biology"},"translated_abstract":"Understanding the mechanisms responsible for the resistance against chemotherapy-induced cell death is still of great interest since the number of patients with cancer increases and relapse is commonly observed. Indeed, the development of hypoxic regions as well as UPR (unfolded protein response) activation are known to promote cancer cell adaptive responses to the stressful tumor microenvironment and resistance against anti-cancer therapies. Therefore, the impact of UPR combined to hypoxia on autophagy and apoptosis activation during taxol exposure was investigated in MDA-MB-231 and T47D breast cancer cells. The results showed that taxol rapidly induced UPR activation and that hypoxia modulated taxol-induced UPR activation differently according to the different UPR pathways (PERK, ATF6 and IRE1α). The putative involvement of these signalling pathways in autophagy or in apoptosis regulation in response to taxol exposure was investigated. However, while no link between the activation...","internal_url":"https://www.academia.edu/95273580/Taxol_induced_Unfolded_Protein_Response_activation_in_breast_cancer_cells_exposed_to_hypoxia_ATF4_activation_regulates_autophagy_and_inhibits_apoptosis","translated_internal_url":"","created_at":"2023-01-18T22:56:00.707-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33692092,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97500471,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500471/thumbnails/1.jpg","file_name":"Notte_UPR_2015_IJBCB.pdf","download_url":"https://www.academia.edu/attachments/97500471/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Taxol_induced_Unfolded_Protein_Response.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500471/Notte_UPR_2015_IJBCB-libre.pdf?1674114617=\u0026response-content-disposition=attachment%3B+filename%3DTaxol_induced_Unfolded_Protein_Response.pdf\u0026Expires=1732731799\u0026Signature=NniyRK~fWqY9e0sVYMYu7M64zJQOoKWNE~N6c5~j3PUQsZoJ4xoGLRhsn3Y8C0KBfrxda6pCXlVlY-qTnIHPajU1R2K3FI4PA2zUibqc2DAW34Jj1WHvDfZnOQCGV0BMEvfObXEOm1Y~8oKSkL4OsbVvbkZGwoUelUtoht4RSbsycNJUSr74VvIt4h-yXw6KORO7reudyTQ21IC1zkCGRMqYGaBkNA0BAFTGHC~e9quAXqBpZTSUmZYeJkOgEMtGs5GNXizWMdjYl~xguP2T0LGZ~k8NRGkwvgUL5I2mgCOaQSLHcAg~EJeK639cqRlcXkw1D1tzLlZJRrEx2wQREw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Taxol_induced_Unfolded_Protein_Response_activation_in_breast_cancer_cells_exposed_to_hypoxia_ATF4_activation_regulates_autophagy_and_inhibits_apoptosis","translated_slug":"","page_count":15,"language":"en","content_type":"Work","owner":{"id":33692092,"first_name":"Carine","middle_initials":null,"last_name":"Michiels","page_name":"CarineMichiels","domain_name":"lambiotte","created_at":"2015-08-06T23:03:11.643-07:00","display_name":"Carine Michiels","url":"https://lambiotte.academia.edu/CarineMichiels"},"attachments":[{"id":97500471,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500471/thumbnails/1.jpg","file_name":"Notte_UPR_2015_IJBCB.pdf","download_url":"https://www.academia.edu/attachments/97500471/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Taxol_induced_Unfolded_Protein_Response.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500471/Notte_UPR_2015_IJBCB-libre.pdf?1674114617=\u0026response-content-disposition=attachment%3B+filename%3DTaxol_induced_Unfolded_Protein_Response.pdf\u0026Expires=1732731799\u0026Signature=NniyRK~fWqY9e0sVYMYu7M64zJQOoKWNE~N6c5~j3PUQsZoJ4xoGLRhsn3Y8C0KBfrxda6pCXlVlY-qTnIHPajU1R2K3FI4PA2zUibqc2DAW34Jj1WHvDfZnOQCGV0BMEvfObXEOm1Y~8oKSkL4OsbVvbkZGwoUelUtoht4RSbsycNJUSr74VvIt4h-yXw6KORO7reudyTQ21IC1zkCGRMqYGaBkNA0BAFTGHC~e9quAXqBpZTSUmZYeJkOgEMtGs5GNXizWMdjYl~xguP2T0LGZ~k8NRGkwvgUL5I2mgCOaQSLHcAg~EJeK639cqRlcXkw1D1tzLlZJRrEx2wQREw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":6802,"name":"Breast Cancer","url":"https://www.academia.edu/Documents/in/Breast_Cancer"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":10990,"name":"Hypoxia","url":"https://www.academia.edu/Documents/in/Hypoxia"},{"id":17923,"name":"Autophagy","url":"https://www.academia.edu/Documents/in/Autophagy"},{"id":22255,"name":"Cancer Research","url":"https://www.academia.edu/Documents/in/Cancer_Research"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":117915,"name":"Unfolded Protein Response","url":"https://www.academia.edu/Documents/in/Unfolded_Protein_Response"},{"id":168351,"name":"Paclitaxel","url":"https://www.academia.edu/Documents/in/Paclitaxel"},{"id":175490,"name":"Programmed cell death","url":"https://www.academia.edu/Documents/in/Programmed_cell_death"},{"id":324687,"name":"UPR","url":"https://www.academia.edu/Documents/in/UPR"},{"id":506082,"name":"Cancer Cell","url":"https://www.academia.edu/Documents/in/Cancer_Cell"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":2039739,"name":"Down-Regulation","url":"https://www.academia.edu/Documents/in/Down-Regulation"},{"id":2847999,"name":"Breast Neoplasms","url":"https://www.academia.edu/Documents/in/Breast_Neoplasms"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95273579"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273579/Cycling_hypoxia_induces_a_specific_amplified_inflammatory_phenotype_in_endothelial_cells_and_enhances_tumor_promoting_inflammation_in_vivo"><img alt="Research paper thumbnail of Cycling hypoxia induces a specific amplified inflammatory phenotype in endothelial cells and enhances tumor-promoting inflammation in vivo" class="work-thumbnail" src="https://attachments.academia-assets.com/97500509/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273579/Cycling_hypoxia_induces_a_specific_amplified_inflammatory_phenotype_in_endothelial_cells_and_enhances_tumor_promoting_inflammation_in_vivo">Cycling hypoxia induces a specific amplified inflammatory phenotype in endothelial cells and enhances tumor-promoting inflammation in vivo</a></div><div class="wp-workCard_item"><span>Neoplasia (New York, N.Y.)</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Abnormal architecture of the tumor blood network, as well as heterogeneous erythrocyte flow, lead...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Abnormal architecture of the tumor blood network, as well as heterogeneous erythrocyte flow, leads to temporal fluctuations in tissue oxygen tension exposing tumor and stromal cells to cycling hypoxia. Inflammation is another feature of tumor microenvironment and is considered as a new enabling characteristic of tumor progression. As cycling hypoxia is known to participate in tumor aggressiveness, the purpose of this study was to evaluate its role in tumor-promoting inflammation. Firstly, we assessed the impact of cycling hypoxia in vitro on endothelial inflammatory response induced by tumor necrosis factor α. Results showed that endothelial cells exposed to cycling hypoxia displayed an amplified proinflammatory phenotype, characterized by an increased expression of inflammatory cytokines, namely, interleukin (IL)-6 and IL-8; by an increased expression of adhesion molecules, in particular intercellular adhesion molecule-1 (ICAM-1); and consequently by an increase in THP-1 monocyte a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e7fbac6e8c8c7b907875fff053c3fc67" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500509,"asset_id":95273579,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500509/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273579"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273579"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273579; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273579]").text(description); $(".js-view-count[data-work-id=95273579]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273579; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273579']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273579, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e7fbac6e8c8c7b907875fff053c3fc67" } } $('.js-work-strip[data-work-id=95273579]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273579,"title":"Cycling hypoxia induces a specific amplified inflammatory phenotype in endothelial cells and enhances tumor-promoting inflammation in vivo","translated_title":"","metadata":{"abstract":"Abnormal architecture of the tumor blood network, as well as heterogeneous erythrocyte flow, leads to temporal fluctuations in tissue oxygen tension exposing tumor and stromal cells to cycling hypoxia. Inflammation is another feature of tumor microenvironment and is considered as a new enabling characteristic of tumor progression. As cycling hypoxia is known to participate in tumor aggressiveness, the purpose of this study was to evaluate its role in tumor-promoting inflammation. Firstly, we assessed the impact of cycling hypoxia in vitro on endothelial inflammatory response induced by tumor necrosis factor α. Results showed that endothelial cells exposed to cycling hypoxia displayed an amplified proinflammatory phenotype, characterized by an increased expression of inflammatory cytokines, namely, interleukin (IL)-6 and IL-8; by an increased expression of adhesion molecules, in particular intercellular adhesion molecule-1 (ICAM-1); and consequently by an increase in THP-1 monocyte a...","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Neoplasia (New York, N.Y.)"},"translated_abstract":"Abnormal architecture of the tumor blood network, as well as heterogeneous erythrocyte flow, leads to temporal fluctuations in tissue oxygen tension exposing tumor and stromal cells to cycling hypoxia. Inflammation is another feature of tumor microenvironment and is considered as a new enabling characteristic of tumor progression. As cycling hypoxia is known to participate in tumor aggressiveness, the purpose of this study was to evaluate its role in tumor-promoting inflammation. Firstly, we assessed the impact of cycling hypoxia in vitro on endothelial inflammatory response induced by tumor necrosis factor α. Results showed that endothelial cells exposed to cycling hypoxia displayed an amplified proinflammatory phenotype, characterized by an increased expression of inflammatory cytokines, namely, interleukin (IL)-6 and IL-8; by an increased expression of adhesion molecules, in particular intercellular adhesion molecule-1 (ICAM-1); and consequently by an increase in THP-1 monocyte a...","internal_url":"https://www.academia.edu/95273579/Cycling_hypoxia_induces_a_specific_amplified_inflammatory_phenotype_in_endothelial_cells_and_enhances_tumor_promoting_inflammation_in_vivo","translated_internal_url":"","created_at":"2023-01-18T22:56:00.598-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33692092,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97500509,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500509/thumbnails/1.jpg","file_name":"pmc4309725.pdf","download_url":"https://www.academia.edu/attachments/97500509/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cycling_hypoxia_induces_a_specific_ampli.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500509/pmc4309725-libre.pdf?1674114575=\u0026response-content-disposition=attachment%3B+filename%3DCycling_hypoxia_induces_a_specific_ampli.pdf\u0026Expires=1732731799\u0026Signature=CQ6Oucx2GhWRSm7UATjVLyYkM53HfC~PoM53fNxT2BDZHTWmT0PDO0r1ejjgD4N064ZeZovYJaU5Fx5r6uNOznTZxw7bjVLkwrT2Uu1bHoWU9myxEU6EEaLzD3Z2rDVBS73SYFeRp7KnKzICQWdaCK-Js1oGiluG3O5ePCmzZktYs7wCkEgSCLnBb6kk1bi8gT0G9rfiqJS92fsWBAuUs5OM2k4Fi04wYZqLOsNBi7Ls4PsyO3AG1WNNgT6hbgxmoWGuS~5rhJ0fnYoz8S2WwnMM0OVFvK0YbL4eHQFPTMFvpzU8TNbcOIUkrU69f3-DgSc2Wymek3S657DGyzG-Iw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Cycling_hypoxia_induces_a_specific_amplified_inflammatory_phenotype_in_endothelial_cells_and_enhances_tumor_promoting_inflammation_in_vivo","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":33692092,"first_name":"Carine","middle_initials":null,"last_name":"Michiels","page_name":"CarineMichiels","domain_name":"lambiotte","created_at":"2015-08-06T23:03:11.643-07:00","display_name":"Carine Michiels","url":"https://lambiotte.academia.edu/CarineMichiels"},"attachments":[{"id":97500509,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500509/thumbnails/1.jpg","file_name":"pmc4309725.pdf","download_url":"https://www.academia.edu/attachments/97500509/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Cycling_hypoxia_induces_a_specific_ampli.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500509/pmc4309725-libre.pdf?1674114575=\u0026response-content-disposition=attachment%3B+filename%3DCycling_hypoxia_induces_a_specific_ampli.pdf\u0026Expires=1732731799\u0026Signature=CQ6Oucx2GhWRSm7UATjVLyYkM53HfC~PoM53fNxT2BDZHTWmT0PDO0r1ejjgD4N064ZeZovYJaU5Fx5r6uNOznTZxw7bjVLkwrT2Uu1bHoWU9myxEU6EEaLzD3Z2rDVBS73SYFeRp7KnKzICQWdaCK-Js1oGiluG3O5ePCmzZktYs7wCkEgSCLnBb6kk1bi8gT0G9rfiqJS92fsWBAuUs5OM2k4Fi04wYZqLOsNBi7Ls4PsyO3AG1WNNgT6hbgxmoWGuS~5rhJ0fnYoz8S2WwnMM0OVFvK0YbL4eHQFPTMFvpzU8TNbcOIUkrU69f3-DgSc2Wymek3S657DGyzG-Iw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":9111,"name":"Cytokines","url":"https://www.academia.edu/Documents/in/Cytokines"},{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":67133,"name":"Anoxia","url":"https://www.academia.edu/Documents/in/Anoxia"},{"id":71510,"name":"Endothelial Cells","url":"https://www.academia.edu/Documents/in/Endothelial_Cells"},{"id":71936,"name":"Tumor Hypoxia","url":"https://www.academia.edu/Documents/in/Tumor_Hypoxia"},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice"},{"id":123418,"name":"NF-kappa B","url":"https://www.academia.edu/Documents/in/NF-kappa_B"},{"id":151098,"name":"Neoplasia","url":"https://www.academia.edu/Documents/in/Neoplasia"},{"id":213897,"name":"Phenotype","url":"https://www.academia.edu/Documents/in/Phenotype"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":469018,"name":"Neoplasms","url":"https://www.academia.edu/Documents/in/Neoplasms"},{"id":474029,"name":"Tumor necrosis factor-alpha","url":"https://www.academia.edu/Documents/in/Tumor_necrosis_factor-alpha"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis"},{"id":4073093,"name":"Inflammation Mediators","url":"https://www.academia.edu/Documents/in/Inflammation_Mediators"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95273578"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273578/Effect_of_Hydroxyethylrutosides_on_Hypoxial_Induced_Neutrophil_Adherence_to_Umbilical_Vein_Endothelium"><img alt="Research paper thumbnail of Effect of Hydroxyethylrutosides on Hypoxial-Induced Neutrophil Adherence to Umbilical Vein Endothelium" class="work-thumbnail" src="https://attachments.academia-assets.com/97500468/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273578/Effect_of_Hydroxyethylrutosides_on_Hypoxial_Induced_Neutrophil_Adherence_to_Umbilical_Vein_Endothelium">Effect of Hydroxyethylrutosides on Hypoxial-Induced Neutrophil Adherence to Umbilical Vein Endothelium</a></div><div class="wp-workCard_item"><span>Cardiovascular Drugs and Therapy - CARDIOVASC DRUG THERAPY</span><span>, 1998</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A clinically available mixture of hydroxyethylrutosides (HR) was examined as a protector against ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A clinically available mixture of hydroxyethylrutosides (HR) was examined as a protector against endothelial cell activation by hypoxia in perfused human umbilical vein. The results showed that 500 µg/mL HR totally inhibited the adherence of human unstimulated neutrophils to the endothelium of umbilical vein incubated in hypoxic conditions. This inhibition was confirmed by a morphological study performed by scanning electron microscopy. In addition, neutrophils adherent to the hypoxic umbilical vein endothelium became activated, as evidenced by the increased release of superoxide anions and synthesis of leukotriene B4. These processes could also be inhibited by HR. In conclusion, the results of this study suggest that the improvement in venous insufficiency observed clinically with HR could, in part, be the result of their ability to inhibit the recruitment and activation of neutrophils by endothelium activated during blood stasis.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a909f33b6a87c172666a0258c39316fe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500468,"asset_id":95273578,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500468/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273578"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273578"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273578; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273578]").text(description); $(".js-view-count[data-work-id=95273578]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273578; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273578']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273578, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a909f33b6a87c172666a0258c39316fe" } } $('.js-work-strip[data-work-id=95273578]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273578,"title":"Effect of Hydroxyethylrutosides on Hypoxial-Induced Neutrophil Adherence to Umbilical Vein Endothelium","translated_title":"","metadata":{"abstract":"A clinically available mixture of hydroxyethylrutosides (HR) was examined as a protector against endothelial cell activation by hypoxia in perfused human umbilical vein. The results showed that 500 µg/mL HR totally inhibited the adherence of human unstimulated neutrophils to the endothelium of umbilical vein incubated in hypoxic conditions. This inhibition was confirmed by a morphological study performed by scanning electron microscopy. In addition, neutrophils adherent to the hypoxic umbilical vein endothelium became activated, as evidenced by the increased release of superoxide anions and synthesis of leukotriene B4. These processes could also be inhibited by HR. In conclusion, the results of this study suggest that the improvement in venous insufficiency observed clinically with HR could, in part, be the result of their ability to inhibit the recruitment and activation of neutrophils by endothelium activated during blood stasis.","publication_date":{"day":null,"month":null,"year":1998,"errors":{}},"publication_name":"Cardiovascular Drugs and Therapy - CARDIOVASC DRUG THERAPY"},"translated_abstract":"A clinically available mixture of hydroxyethylrutosides (HR) was examined as a protector against endothelial cell activation by hypoxia in perfused human umbilical vein. The results showed that 500 µg/mL HR totally inhibited the adherence of human unstimulated neutrophils to the endothelium of umbilical vein incubated in hypoxic conditions. This inhibition was confirmed by a morphological study performed by scanning electron microscopy. In addition, neutrophils adherent to the hypoxic umbilical vein endothelium became activated, as evidenced by the increased release of superoxide anions and synthesis of leukotriene B4. These processes could also be inhibited by HR. In conclusion, the results of this study suggest that the improvement in venous insufficiency observed clinically with HR could, in part, be the result of their ability to inhibit the recruitment and activation of neutrophils by endothelium activated during blood stasis.","internal_url":"https://www.academia.edu/95273578/Effect_of_Hydroxyethylrutosides_on_Hypoxial_Induced_Neutrophil_Adherence_to_Umbilical_Vein_Endothelium","translated_internal_url":"","created_at":"2023-01-18T22:56:00.127-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33692092,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97500468,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500468/thumbnails/1.jpg","file_name":"A_1007772817842.pdf","download_url":"https://www.academia.edu/attachments/97500468/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Effect_of_Hydroxyethylrutosides_on_Hypox.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500468/A_1007772817842-libre.pdf?1674114574=\u0026response-content-disposition=attachment%3B+filename%3DEffect_of_Hydroxyethylrutosides_on_Hypox.pdf\u0026Expires=1732731799\u0026Signature=P5JS9XAvBX3JEE67x~x4fLileXRqvjh2qc4WEHuHi82c3zLBEt~~Q-KYHXyT9JQGzFESaouqbb4R6Q8UKWzypwAYlkhcoWn0Wu2isExefyuoS4U~JlSawa00W-4k0gBdbKHWJF~z50gAV7QnqVFua61ItcoodLJypLglWPAV59SH7pb7OEHgO0jhTrbHGgoYmDN7GIyATquiRK-DddcRkRzOaLtbPmKfkEHmFsgvx8DaIbisvXN7bd-mw0LYn~tapiawJjOZ3fhWK69v4BY8VIlQNINRTRBlQVIiKNgjXJ9UPDZeIUzqUYF0hv42kmYENfGIGjCXvlI5PPd2xLID5A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Effect_of_Hydroxyethylrutosides_on_Hypoxial_Induced_Neutrophil_Adherence_to_Umbilical_Vein_Endothelium","translated_slug":"","page_count":2,"language":"en","content_type":"Work","owner":{"id":33692092,"first_name":"Carine","middle_initials":null,"last_name":"Michiels","page_name":"CarineMichiels","domain_name":"lambiotte","created_at":"2015-08-06T23:03:11.643-07:00","display_name":"Carine 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sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[{"id":28192827,"url":"http://www.springerlink.com/content/w10r06lh5200435v"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95273577"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273577/Chemical_reactivity_of_plasma_polymerized_allylamine_PPAA_thin_films_on_Au_and_Si_Study_of_the_thickness_influence_and_aging_of_the_films"><img alt="Research paper thumbnail of Chemical reactivity of plasma polymerized allylamine (PPAA) thin films on Au and Si: Study of the thickness influence and aging of the films" class="work-thumbnail" src="https://attachments.academia-assets.com/97500467/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273577/Chemical_reactivity_of_plasma_polymerized_allylamine_PPAA_thin_films_on_Au_and_Si_Study_of_the_thickness_influence_and_aging_of_the_films">Chemical reactivity of plasma polymerized allylamine (PPAA) thin films on Au and Si: Study of the thickness influence and aging of the films</a></div><div class="wp-workCard_item"><span>Surface and Coatings Technology</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ae9f98d09d0352e6df2eaed9fb8c2864" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" 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waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ae9f98d09d0352e6df2eaed9fb8c2864" } } $('.js-work-strip[data-work-id=95273577]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273577,"title":"Chemical reactivity of plasma polymerized allylamine (PPAA) thin films on Au and Si: Study of the thickness influence and aging of the films","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"In this work, we investigate the surface reactivity of substrates coated with thin layers (estimated thickness ≤ 30 nm) of plasma polymerized allylamine films (PPAA), an amine-functionalized polymer deposited by plasma-enhanced chemical vapor deposition (PECVD) with radiofrequency (RF) discharges. Our results show that very thin layers, or islands, can retain on their surface molecules that are able to react through their NH 2 functions. We have tested and assessed by X-Ray Electron Spectroscopy (XPS) and Quartz Crystal Microbalance (QCM) the surface density of chemical functions vs. layer thicknesses by using chemical derivatization with two types of agents: imine formation by a reaction of primary amine from the coating with aldehyde (Pentafluorobenzaldehyde, PFBA) and amide-bond formation by reaction with an activated carboxylic group (Succinimidyl Succinate Terminated Polyethylene glycol, EGSS). Results show that the PPAA coatings-even for very thin layers of a few nanometers-promote the chemisorption of the tagging molecules. The aging under air and evolution of reactive amine surface concentration with time under air are also presented.","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Surface and Coatings Technology","grobid_abstract_attachment_id":97500467},"translated_abstract":null,"internal_url":"https://www.academia.edu/95273577/Chemical_reactivity_of_plasma_polymerized_allylamine_PPAA_thin_films_on_Au_and_Si_Study_of_the_thickness_influence_and_aging_of_the_films","translated_internal_url":"","created_at":"2023-01-18T22:56:00.022-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33692092,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97500467,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500467/thumbnails/1.jpg","file_name":"moreau2011.pdf","download_url":"https://www.academia.edu/attachments/97500467/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Chemical_reactivity_of_plasma_polymerize.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500467/moreau2011.pdf?1674111421=\u0026response-content-disposition=attachment%3B+filename%3DChemical_reactivity_of_plasma_polymerize.pdf\u0026Expires=1732731799\u0026Signature=RX21hqe1svSsM7pAhblVwjFx-tBd3MyfPXwfPfVX-BlOtukUNJYugFvXQFgB-6AnZvxOudZgOIu3yiWcFx7yOmLYotrMO6~d5F2CHWgaJToycltSz99W8vX2~ngGmSzjhm~RstYio06Gxv0NvsgugIwNjQcZIeNC4S~BEKedeDWGPta9RihqFyHrWGqJVJMa5tlww5uR5Q3zNN0k9biEXT2u48BjYLZuwjx9G6FLcRvm0EUBBtLx7UnKQBPkQVLXKn~g9HOJbiv2z2Zh-dkUk2dcYjg7kDO6oFnByqQRJrngKSUzh6oaOKETxXnxUupz5TCKqMiWLXm9Pm9b~9IKJw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Chemical_reactivity_of_plasma_polymerized_allylamine_PPAA_thin_films_on_Au_and_Si_Study_of_the_thickness_influence_and_aging_of_the_films","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":33692092,"first_name":"Carine","middle_initials":null,"last_name":"Michiels","page_name":"CarineMichiels","domain_name":"lambiotte","created_at":"2015-08-06T23:03:11.643-07:00","display_name":"Carine 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biological tissues to break or modify the DNA, which is the molecule contained in the nuclei of cells that carries all the relevant information for the organism. As such, radiation is dangerous for individuals; however, its properties can also be used in medicine, e. g. in cancer treatments. Nevertheless, the exact mechanisms of cellular response to radiation are not fully understood yet, especially for low doses (below 50 cGy), where non-targeted effects, i. e. that do not involve only the interactions radiation-DNA, are taking place. In order to deepen the knowledge of those non-targeted effects, a computer model of a population of cells irradiated in vitro was written, taking into account the phenomena in the low dose domain. \" Liliana, for the afternoon tea times, and chats about life, boyfriends, supervisor and occasionally, scientific issues;. Many others: Kevin Prise, Mick Woodcock and Giuseppe Schettino for the scientific advice, Raj and Marie-Laure for the moral support, Giselle, Joshua, Guillermo, Alicia, Graham and the Oxfam team and St John's homegroup... who have made my life easier in one way or another. 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});</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273574, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "953a6dc1323a380782cfdacbf5d2566a" } } $('.js-work-strip[data-work-id=95273574]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273574,"title":"Low-LET Proton Irradiation of A549 Non-small Cell Lung Adenocarcinoma Cells: Dose Response and RBE Determination","translated_title":"","metadata":{"publisher":"Radiation Research Society","grobid_abstract":"Since 1957, broad proton beam radiotherapy with a spread out Bragg peak has been used for cancer treatment. More recently, studies on the use of proton therapy in the treatment of nonsmall-cell lung cancer (NSCLC) were performed and, although the benefit of using protons for the treatment of NSCLC is recognized, more work is needed to gather additional data for the understanding of cell response. Human A549 cell survival was evaluated by colony forming assay 11 days after 10 keV/µm proton beam irradiation at 0.1 and 1 Gy/min. The residual energy of the proton beam at the location of the irradiated cells was 3.9 MeV. In parallel, early effects on the cell viability and DNA damage were assessed and DNA synthesis was measured. The survival curve obtained was fitted with both the Linear and the Induced-Repair models as a hyper-radiosensitivity was evidenced at very low doses. Above 0.5 Gy, a linear shape was observed with the  parameter equal to 0.824 ± 0.029 Gy-1. Early cell death and cell proliferation arrest were highlighted. Moreover, a clear correlation between DNA damage and surviving fraction was observed. Finally, comparisons with X results indicate that proton irradiation at 10 keV/µm enhances the tumor radiosensitivity with a significant dose-dependent decrease in the survival fraction. The RBE value of 1.9 ± 0.4 obtained for a 10% survival supports this observation. This is the first study to show that low LET proton irradiation of lung cancer cells evidenced hyper-radiosensitivity with a high RBE value.","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Radiation Research","grobid_abstract_attachment_id":97500469},"translated_abstract":null,"internal_url":"https://www.academia.edu/95273574/Low_LET_Proton_Irradiation_of_A549_Non_small_Cell_Lung_Adenocarcinoma_Cells_Dose_Response_and_RBE_Determination","translated_internal_url":"","created_at":"2023-01-18T22:55:59.711-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33692092,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97500469,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500469/thumbnails/1.jpg","file_name":"W_ra_proton.pdf","download_url":"https://www.academia.edu/attachments/97500469/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Low_LET_Proton_Irradiation_of_A549_Non_s.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500469/W_ra_proton-libre.pdf?1674114580=\u0026response-content-disposition=attachment%3B+filename%3DLow_LET_Proton_Irradiation_of_A549_Non_s.pdf\u0026Expires=1732731799\u0026Signature=Y4wkJV1fhdZNfyyoBGVZwKnUUW-fv00D7He81PEdjUnNAaHAtu6-Dc8uyBx4m66kqEDC169vQ4NFb-79jxAbnIIPoXa7LFIwABxRXD-4XjDwGuNZsd30gFOlnGYUgq~k~YI93LEhKvKeiVosVEgLy2fA4qR9O0MuC49Db-qJZIqkBQLO7QmgkeX~MwtY~mc7aGer5jYgVVuPuNRB2DlVlK1st8caTDZKmggt17HNv6qlAFjr7pxb7cissDrtYd49SFF3e-CLIvEeZW5K3YfmsIfGHal9EHfzleM48041n682xRHY1iRPNZsr6KtoSDvokqT3L1S8wXp1oJdqFOot6g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Low_LET_Proton_Irradiation_of_A549_Non_small_Cell_Lung_Adenocarcinoma_Cells_Dose_Response_and_RBE_Determination","translated_slug":"","page_count":34,"language":"en","content_type":"Work","owner":{"id":33692092,"first_name":"Carine","middle_initials":null,"last_name":"Michiels","page_name":"CarineMichiels","domain_name":"lambiotte","created_at":"2015-08-06T23:03:11.643-07:00","display_name":"Carine Michiels","url":"https://lambiotte.academia.edu/CarineMichiels"},"attachments":[{"id":97500469,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500469/thumbnails/1.jpg","file_name":"W_ra_proton.pdf","download_url":"https://www.academia.edu/attachments/97500469/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Low_LET_Proton_Irradiation_of_A549_Non_s.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500469/W_ra_proton-libre.pdf?1674114580=\u0026response-content-disposition=attachment%3B+filename%3DLow_LET_Proton_Irradiation_of_A549_Non_s.pdf\u0026Expires=1732731799\u0026Signature=Y4wkJV1fhdZNfyyoBGVZwKnUUW-fv00D7He81PEdjUnNAaHAtu6-Dc8uyBx4m66kqEDC169vQ4NFb-79jxAbnIIPoXa7LFIwABxRXD-4XjDwGuNZsd30gFOlnGYUgq~k~YI93LEhKvKeiVosVEgLy2fA4qR9O0MuC49Db-qJZIqkBQLO7QmgkeX~MwtY~mc7aGer5jYgVVuPuNRB2DlVlK1st8caTDZKmggt17HNv6qlAFjr7pxb7cissDrtYd49SFF3e-CLIvEeZW5K3YfmsIfGHal9EHfzleM48041n682xRHY1iRPNZsr6KtoSDvokqT3L1S8wXp1oJdqFOot6g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":1328,"name":"Radiation","url":"https://www.academia.edu/Documents/in/Radiation"},{"id":10030,"name":"Radiation Therapy","url":"https://www.academia.edu/Documents/in/Radiation_Therapy"},{"id":10035,"name":"Nuclear medicine","url":"https://www.academia.edu/Documents/in/Nuclear_medicine"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":118582,"name":"Physical sciences","url":"https://www.academia.edu/Documents/in/Physical_sciences"},{"id":439023,"name":"Irradiation","url":"https://www.academia.edu/Documents/in/Irradiation"},{"id":562564,"name":"Proton","url":"https://www.academia.edu/Documents/in/Proton"},{"id":832191,"name":"Relative Biological Effectiveness","url":"https://www.academia.edu/Documents/in/Relative_Biological_Effectiveness"},{"id":879919,"name":"Radiosensitivity","url":"https://www.academia.edu/Documents/in/Radiosensitivity"},{"id":1208793,"name":"Protons","url":"https://www.academia.edu/Documents/in/Protons"},{"id":1745478,"name":"Adenocarcinoma","url":"https://www.academia.edu/Documents/in/Adenocarcinoma"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"},{"id":3840853,"name":"lung neoplasms","url":"https://www.academia.edu/Documents/in/lung_neoplasms"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95273573"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273573/89Zr_labeled_anti_endoglin_antibody_targeted_gold_nanoparticles_for_imaging_cancer_implications_for_future_cancer_therapy"><img alt="Research paper thumbnail of 89Zr-labeled anti-endoglin antibody-targeted gold nanoparticles for imaging cancer: implications for future cancer therapy" class="work-thumbnail" src="https://attachments.academia-assets.com/97500496/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273573/89Zr_labeled_anti_endoglin_antibody_targeted_gold_nanoparticles_for_imaging_cancer_implications_for_future_cancer_therapy">89Zr-labeled anti-endoglin antibody-targeted gold nanoparticles for imaging cancer: implications for future cancer therapy</a></div><div class="wp-workCard_item"><span>Nanomedicine</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aims: Antibody-labeled gold nanoparticles represent an attractive tool for cancer imaging and the...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aims: Antibody-labeled gold nanoparticles represent an attractive tool for cancer imaging and therapy. In this study, the anti-CD105 antibody was conjugated with gold nanoparticles (AuNPs) for the first time. The antibody biodistribution in mice before and after conjugation to AuNPs was studied, with a focus on tumor targeting. Materials & methods: Antibodies were radiolabeled with 89Zr before conjugation to AuNPs (5 nm). Immunonanoconjugates were characterized in vitro in terms of size, stability in plasma and binding to the target. Quantitative PET imaging and ICP-MS analysis assessed in vivo distribution and specific tumor targeting of tracers. Results: The tumor uptake of immunoconjugates was preserved up to 24 h after injection, with high tumor contrast and selective tumor targeting. No major tracer accumulation was observed over time in nonspecific organs. ICP-MS analysis confirmed the antibody specificity after nanoparticle conjugation. Conclusion: The anti-CD105 antibody con...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="93b3b38d01e2cdfca221f8a2d2a72948" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500496,"asset_id":95273573,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500496/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273573"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273573"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273573; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273573]").text(description); $(".js-view-count[data-work-id=95273573]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273573; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273573']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273573, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "93b3b38d01e2cdfca221f8a2d2a72948" } } $('.js-work-strip[data-work-id=95273573]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273573,"title":"89Zr-labeled anti-endoglin antibody-targeted gold nanoparticles for imaging cancer: implications for future cancer therapy","translated_title":"","metadata":{"abstract":"Aims: Antibody-labeled gold nanoparticles represent an attractive tool for cancer imaging and therapy. In this study, the anti-CD105 antibody was conjugated with gold nanoparticles (AuNPs) for the first time. The antibody biodistribution in mice before and after conjugation to AuNPs was studied, with a focus on tumor targeting. Materials \u0026 methods: Antibodies were radiolabeled with 89Zr before conjugation to AuNPs (5 nm). Immunonanoconjugates were characterized in vitro in terms of size, stability in plasma and binding to the target. Quantitative PET imaging and ICP-MS analysis assessed in vivo distribution and specific tumor targeting of tracers. Results: The tumor uptake of immunoconjugates was preserved up to 24 h after injection, with high tumor contrast and selective tumor targeting. No major tracer accumulation was observed over time in nonspecific organs. ICP-MS analysis confirmed the antibody specificity after nanoparticle conjugation. Conclusion: The anti-CD105 antibody con...","publisher":"Future Medicine Ltd","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Nanomedicine"},"translated_abstract":"Aims: Antibody-labeled gold nanoparticles represent an attractive tool for cancer imaging and therapy. In this study, the anti-CD105 antibody was conjugated with gold nanoparticles (AuNPs) for the first time. The antibody biodistribution in mice before and after conjugation to AuNPs was studied, with a focus on tumor targeting. Materials \u0026 methods: Antibodies were radiolabeled with 89Zr before conjugation to AuNPs (5 nm). Immunonanoconjugates were characterized in vitro in terms of size, stability in plasma and binding to the target. Quantitative PET imaging and ICP-MS analysis assessed in vivo distribution and specific tumor targeting of tracers. Results: The tumor uptake of immunoconjugates was preserved up to 24 h after injection, with high tumor contrast and selective tumor targeting. No major tracer accumulation was observed over time in nonspecific organs. ICP-MS analysis confirmed the antibody specificity after nanoparticle conjugation. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="95273571"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273571/Hypoxia_induces_protection_against_etoposide_induced_apoptosis_molecular_profiling_of_changes_in_gene_expression_and_transcription_factor_activity"><img alt="Research paper thumbnail of Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity" class="work-thumbnail" src="https://attachments.academia-assets.com/97500431/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273571/Hypoxia_induces_protection_against_etoposide_induced_apoptosis_molecular_profiling_of_changes_in_gene_expression_and_transcription_factor_activity">Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity</a></div><div class="wp-workCard_item"><span>Molecular Cancer</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background it is now well established that hypoxia renders tumor cells resistant to radio- but al...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background it is now well established that hypoxia renders tumor cells resistant to radio- but also chemotherapy. However, few elements are currently available as for the mechanisms underlying this protection. Results in this study, physiological hypoxia was shown to inhibit apoptosis induced in HepG2 cells by etoposide. Indeed, hypoxia reduced DNA fragmentation, caspase activation and PARP cleavage. The DNA binding activity of 10 transcription factors was followed while the actual transcriptional activity was measured using specific reporter plasmids. Of note is the inhibition of the etoposide-induced activation of p53 under hypoxia. In parallel, data from low density DNA microarrays indicate that the expression of several pro- and anti-apoptotic genes was modified, among which are Bax and Bak whose expression profile paralleled p53 activity. Cluster analysis of data unravels several possible pathways involved in the hypoxia-induced protection against etoposide-induced apoptosis: o...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cb4aeb29afc6dec425d4d8ff719e2c0c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500431,"asset_id":95273571,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500431/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273571"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="95273571"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 95273571; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=95273571]").text(description); $(".js-view-count[data-work-id=95273571]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 95273571; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='95273571']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 95273571, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cb4aeb29afc6dec425d4d8ff719e2c0c" } } $('.js-work-strip[data-work-id=95273571]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273571,"title":"Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity","translated_title":"","metadata":{"abstract":"Background it is now well established that hypoxia renders tumor cells resistant to radio- but also chemotherapy. 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data-work-id="95273570"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/95273570/Erratum_to_Caspase_activation_precedes_PTP_opening_in_TNF_%CE%B1_induced_apoptosis_in_L929_cells_Mitochondrion_3_2004_261_278_"><img alt="Research paper thumbnail of Erratum to “Caspase activation precedes PTP opening in TNF-α-induced apoptosis in L929 cells” [Mitochondrion 3 (2004) 261–278]" class="work-thumbnail" src="https://attachments.academia-assets.com/97500472/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273570/Erratum_to_Caspase_activation_precedes_PTP_opening_in_TNF_%CE%B1_induced_apoptosis_in_L929_cells_Mitochondrion_3_2004_261_278_">Erratum to “Caspase activation precedes PTP opening in TNF-α-induced apoptosis in L929 cells” [Mitochondrion 3 (2004) 261–278]</a></div><div class="wp-workCard_item"><span>Mitochondrion</span><span>, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="082996b6496d8a0f80cda8834d4fb25f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500472,"asset_id":95273570,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500472/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273570"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i 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$('.js-work-strip[data-work-id=95273570]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273570,"title":"Erratum to “Caspase activation precedes PTP opening in TNF-α-induced apoptosis in L929 cells” [Mitochondrion 3 (2004) 261–278]","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2005,"errors":{}},"publication_name":"Mitochondrion"},"translated_abstract":null,"internal_url":"https://www.academia.edu/95273570/Erratum_to_Caspase_activation_precedes_PTP_opening_in_TNF_%CE%B1_induced_apoptosis_in_L929_cells_Mitochondrion_3_2004_261_278_","translated_internal_url":"","created_at":"2023-01-18T22:55:59.331-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33692092,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":97500472,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/97500472/thumbnails/1.jpg","file_name":"j.mito.2005.01.00120230119-1-hjb7s8.pdf","download_url":"https://www.academia.edu/attachments/97500472/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Erratum_to_Caspase_activation_precedes_P.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/97500472/j.mito.2005.01.00120230119-1-hjb7s8-libre.pdf?1674114573=\u0026response-content-disposition=attachment%3B+filename%3DErratum_to_Caspase_activation_precedes_P.pdf\u0026Expires=1732731800\u0026Signature=UE5pVq2ngYgqofrYVEyPOFDOAqsDbSFPHPfjrULbQL7p6JT~2vnNchCePCvVXOiiEJcsiB~jGwteqxkRfr1lEDxUs4BV2aCRmwVtaubl3Iq02kFuH75VzAkCIhC2KoaM9-tjfHUQmP2BNYN1kPZkEih28PdaDt-OT5RJ1ivZateF0Y6QyGMl29~tqoKjvi00ZY6SNr5IvgKhAs5J-ZjLpxRlOwqU-vkAQI38kkwyJNnJPRD9rYBSdE7RMFzg4VNL1KAxzNHgk6cN691W5OuC6sexOUkAXQNFvr-OgpMLKuFei3PqfPtn57dTxEJmYXor2XIMk0HSqkodvwA8mtPUpg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Erratum_to_Caspase_activation_precedes_PTP_opening_in_TNF_α_induced_apoptosis_in_L929_cells_Mitochondrion_3_2004_261_278_","translated_slug":"","page_count":2,"language":"en","content_type":"Work","owner":{"id":33692092,"first_name":"Carine","middle_initials":null,"last_name":"Michiels","page_name":"CarineMichiels","domain_name":"lambiotte","created_at":"2015-08-06T23:03:11.643-07:00","display_name":"Carine 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href="https://www.academia.edu/95273569/Radioimmunotherapy_with_radioactive_nanoparticles_Biological_doses_and_treatment_efficiency_for_vascularized_tumors_with_or_without_a_central_hypoxic_area"><img alt="Research paper thumbnail of Radioimmunotherapy with radioactive nanoparticles: Biological doses and treatment efficiency for vascularized tumors with or without a central hypoxic area" class="work-thumbnail" src="https://attachments.academia-assets.com/97500470/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/95273569/Radioimmunotherapy_with_radioactive_nanoparticles_Biological_doses_and_treatment_efficiency_for_vascularized_tumors_with_or_without_a_central_hypoxic_area">Radioimmunotherapy with radioactive nanoparticles: Biological doses and treatment efficiency for vascularized tumors with or without a central hypoxic area</a></div><div class="wp-workCard_item"><span>Medical Physics</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="16335b65e5a4dbccd955a047338dea96" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":97500470,"asset_id":95273569,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/97500470/download_file?st=MTczMjczMTQwOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="95273569"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa 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$('.js-work-strip[data-work-id=95273569]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":95273569,"title":"Radioimmunotherapy with radioactive nanoparticles: Biological doses and treatment efficiency for vascularized tumors with or without a central hypoxic area","translated_title":"","metadata":{"publisher":"Wiley","grobid_abstract":"Radioactive atoms attached to monoclonal antibodies are used in radioimmunotherapy to treat cancer while limiting radiation to healthy tissues. One limitation of this method is that only one radioactive atom is linked to each antibody and the deposited dose is often insufficient to eradicate solid and radioresistant tumors. In a previous study, simulations with the Monte Carlo N-Particle eXtended code showed that physical doses up to 50 Gy can be delivered inside tumors by replacing the single radionuclide by a radioactive nanoparticle of 5 nm diameter containing hundreds of radioactive atoms. However, tumoral and normal tissues are not equally sensitive to radiation, and previous works did not take account the biological effects such as cellular repair processes or the presence of less radiosensitive cells such as hypoxic cells. Methods: The idea is to adapt the linear-quadratic expression to the tumor model and to determine biological effective doses ͑BEDs͒ delivered through and around a tumor. This BED is then incorporated into a Poisson formula to determine the shell control probability ͑SCP͒ which predicts the cell cluster-killing efficiency at different distances \"r\" from the center of the tumor. BED and SCP models are used to analyze the advantages of injecting radioactive nanoparticles instead of a single radionuclide per vector in radioimmunotherapy. Results: Calculations of BED and SCP for different distances r from the center of a solid tumor, using the non-small-cell lung cancer as an example, were investigated for 90 Y 2 O 3 nanoparticles. With a total activity of about 3.5 and 20 MBq for tumor radii of 0.5 and 1.0 cm, respectively, results show that a very high BED is deposited in the well oxygenated part of the spherical carcinoma. Conclusions: For either small or large solid tumors, BED and SCP calculations highlight the important benefit in replacing the single ␤-emitter 90 Y attached to each antibody by a 90 Y 2 O 3 nanoparticle.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Medical 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