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<!DOCTYPE html> <html lang="en" class="no-js"> <head> <meta charset="UTF-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="applicable-device" content="pc,mobile"> <meta name="viewport" content="width=device-width, initial-scale=1"> <meta name="robots" content="max-image-preview:large"> <meta name="access" content="No"> <meta name="360-site-verification" content="1268d79b5e96aecf3ff2a7dac04ad990" /> <title>Design of Experiment (DoE), Screening and Optimization of System Variables to Develop and Validate Greener Spectrophotometric Investigation of Repaglinide | Chemistry Africa</title> <meta name="twitter:site" content="@SpringerLink"/> <meta name="twitter:card" content="summary_large_image"/> <meta name="twitter:image:alt" content="Content cover image"/> <meta name="twitter:title" content="Design of Experiment (DoE), Screening and Optimization of System Variables to Develop and Validate Greener Spectrophotometric Investigation of Repaglinide"/> <meta name="twitter:description" content="Chemistry Africa - Repaglinide (RPG) is appropriate for meglitinides, which screen for rapid insulin secretagogue action to target postprandial hyperglycemia and is preferable to treat type-2..."/> <meta name="twitter:image" content="https://static-content.springer.com/image/art%3A10.1007%2Fs42250-024-01131-w/MediaObjects/42250_2024_1131_Fig1_HTML.png"/> <meta name="journal_id" content="42250"/> <meta name="dc.title" content="Design of Experiment (DoE), Screening and Optimization of System Variables to Develop and Validate Greener Spectrophotometric Investigation of Repaglinide"/> <meta name="dc.source" content="Chemistry Africa 2024"/> <meta name="dc.format" content="text/html"/> <meta name="dc.publisher" content="Springer"/> <meta name="dc.date" content="2024-11-22"/> <meta name="dc.type" content="OriginalPaper"/> <meta name="dc.language" content="En"/> <meta name="dc.copyright" content="2024 The Tunisian Chemical Society and Springer Nature Switzerland AG"/> <meta name="dc.rights" content="2024 The Tunisian Chemical Society and Springer Nature Switzerland AG"/> <meta name="dc.rightsAgent" content="journalpermissions@springernature.com"/> <meta name="dc.description" content="Repaglinide (RPG) is appropriate for meglitinides, which screen for rapid insulin secretagogue action to target postprandial hyperglycemia and is preferable to treat type-2 diabetes. The current investigation determined RPG based on the drug’s reaction with potassium permanganate (KMnO4) in an alkaline medium using visible spectrophotometry at 602&nbsp;nm. The Taguchi model has evaluated the most influential variables, such as reaction time (min), temperature (ºC), KMnO4 concentration (M) and RPG concentration (M), among the preferable parameters estimated by the Fishbone diagram. The setting conditions were optimized as reaction time (10&nbsp;min), temperature (28º), KMnO4 concentration (2.4 × 10− 2 M) and RPG concentration (2.5 × 10− 2 M) with a constant alkaline solution (1 × 10− 2 M) by Box-Behnken design (BBD) combined response surface methodology (RSM). The current approach not only reduced the amount of reagents or solvents but also supported lowering the analysis time and, ultimately, the project cost. The method was validated as per the ICH guidelines. The linearity was in the range of 2–33.5&nbsp;µg/mL with LOD and LOQ values of 0.85 and 2.58&nbsp;µg/mL, respectively. The accuracy and precision results were well organised, and %RSD was within ± 2% and % recovery between 99.11 and 99.89%. The AGREE algorithm determined the greenery value in pictograms for reported and proposed procedures and found that the greenery value of 0.59 of the developed method was the highest compared to other reported methods. Still, all were greener and very close to each other. Therefore, the proposed method could be highly recommended to determine RPG from different sources, likely in API and pharmaceutical formulations."/> <meta name="prism.issn" content="2522-5766"/> <meta name="prism.publicationName" content="Chemistry Africa"/> <meta name="prism.publicationDate" content="2024-11-22"/> <meta name="prism.section" content="OriginalPaper"/> <meta name="prism.startingPage" content="1"/> <meta name="prism.endingPage" content="19"/> <meta name="prism.copyright" content="2024 The Tunisian Chemical Society and Springer Nature Switzerland AG"/> <meta name="prism.rightsAgent" content="journalpermissions@springernature.com"/> <meta name="prism.url" content="https://link.springer.com/article/10.1007/s42250-024-01131-w"/> <meta name="prism.doi" content="doi:10.1007/s42250-024-01131-w"/> <meta name="citation_pdf_url" content="https://link.springer.com/content/pdf/10.1007/s42250-024-01131-w.pdf"/> <meta name="citation_fulltext_html_url" content="https://link.springer.com/article/10.1007/s42250-024-01131-w"/> <meta name="citation_journal_title" content="Chemistry Africa"/> <meta name="citation_journal_abbrev" content="Chemistry Africa"/> <meta name="citation_publisher" content="Springer International Publishing"/> <meta name="citation_issn" content="2522-5766"/> <meta name="citation_title" content="Design of Experiment (DoE), Screening and Optimization of System Variables to Develop and Validate Greener Spectrophotometric Investigation of Repaglinide"/> <meta name="citation_online_date" content="2024/11/22"/> <meta name="citation_firstpage" content="1"/> <meta name="citation_lastpage" content="19"/> <meta name="citation_article_type" content="Original Article"/> <meta name="citation_language" content="en"/> <meta name="dc.identifier" content="doi:10.1007/s42250-024-01131-w"/> <meta name="DOI" content="10.1007/s42250-024-01131-w"/> <meta name="size" content="304867"/> <meta name="citation_doi" content="10.1007/s42250-024-01131-w"/> <meta name="citation_springer_api_url" content="http://api.springer.com/xmldata/jats?q=doi:10.1007/s42250-024-01131-w&api_key="/> <meta name="description" content="Repaglinide (RPG) is appropriate for meglitinides, which screen for rapid insulin secretagogue action to target postprandial hyperglycemia and is preferabl"/> <meta name="dc.creator" content="Haque, SK Manirul"/> <meta name="dc.creator" content="Jain, Rajeev"/> <meta name="dc.creator" content="Umar, Yunusa"/> <meta name="dc.creator" content="Judeh, Ahmed Abu"/> <meta name="dc.creator" content="Alahmari, Saeed D."/> <meta name="dc.creator" content="Alam, Mahboob"/> <meta name="dc.creator" content="Jha, Rakesh Roshan"/> <meta name="dc.subject" content="Chemistry/Food Science, general"/> <meta name="dc.subject" content="Inorganic Chemistry"/> <meta name="dc.subject" content="Organometallic Chemistry"/> <meta name="citation_reference" content="citation_journal_title=MMWR Morb Mortal Wkly Rep; citation_title=Prevalence of arthritis and arthritis– attributablet activity limitation–United States, 2016–2018; citation_author=A Kristina; citation_volume=70; citation_publication_date=2021; citation_pages=1401-1407; citation_doi=10.15585/mmwr.mm7040a2; citation_id=CR1"/> <meta name="citation_reference" content="Moien ABK et al (2020) Epidemiology of type 2 diabetes–global burden of disease and forecasted trends. 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FABAD J Pharm Sci 35:69–75"/> <meta name="citation_author" content="Haque, SK Manirul"/> <meta name="citation_author_email" content="Haque_m@rcjy.edu.sa"/> <meta name="citation_author_institution" content="Department of Chemical Engineering, Jubail Industrial College, Jubail Industrial City, Saudi Arabia"/> <meta name="citation_author" content="Jain, Rajeev"/> <meta name="citation_author_institution" content="Central Forensic Science Laboratory, Forensic Toxicology Division, Chandigarh, India"/> <meta name="citation_author" content="Umar, Yunusa"/> <meta name="citation_author_institution" content="Department of Chemical Engineering, Jubail Industrial College, Jubail Industrial City, Saudi Arabia"/> <meta name="citation_author" content="Judeh, Ahmed Abu"/> <meta name="citation_author_institution" content="Department of Chemical Engineering, Jubail Industrial College, Jubail Industrial City, Saudi Arabia"/> <meta name="citation_author" content="Alahmari, Saeed D."/> <meta name="citation_author_institution" content="Department of Chemistry, Faculty of Science, Jazan University, Jazan, Saudi Arabia"/> <meta name="citation_author" content="Alam, Mahboob"/> <meta name="citation_author_institution" content="Division of Chemistry and Biotechnology, Dongguk Wise University, Gyeongju, Republic of Korea"/> <meta name="citation_author" content="Jha, Rakesh Roshan"/> <meta name="citation_author_institution" content="Centre of Analytical Biosciences, School of Pharmacy, University of Nottingham, Nottingham, UK"/> <meta name="format-detection" content="telephone=no"/> <meta property="og:url" content="https://link.springer.com/article/10.1007/s42250-024-01131-w"/> <meta property="og:type" content="article"/> <meta property="og:site_name" content="SpringerLink"/> <meta property="og:title" content="Design of Experiment (DoE), Screening and Optimization of System Variables to Develop and Validate Greener Spectrophotometric Investigation of Repaglinide - Chemistry Africa"/> <meta property="og:description" content="Repaglinide (RPG) is appropriate for meglitinides, which screen for rapid insulin secretagogue action to target postprandial hyperglycemia and is preferable to treat type-2 diabetes. The current investigation determined RPG based on the drug’s reaction with potassium permanganate (KMnO4) in an alkaline medium using visible spectrophotometry at 602 nm. The Taguchi model has evaluated the most influential variables, such as reaction time (min), temperature (ºC), KMnO4 concentration (M) and RPG concentration (M), among the preferable parameters estimated by the Fishbone diagram. The setting conditions were optimized as reaction time (10 min), temperature (28º), KMnO4 concentration (2.4 × 10− 2 M) and RPG concentration (2.5 × 10− 2 M) with a constant alkaline solution (1 × 10− 2 M) by Box-Behnken design (BBD) combined response surface methodology (RSM). The current approach not only reduced the amount of reagents or solvents but also supported lowering the analysis time and, ultimately, the project cost. The method was validated as per the ICH guidelines. The linearity was in the range of 2–33.5 µg/mL with LOD and LOQ values of 0.85 and 2.58 µg/mL, respectively. The accuracy and precision results were well organised, and %RSD was within ± 2% and % recovery between 99.11 and 99.89%. The AGREE algorithm determined the greenery value in pictograms for reported and proposed procedures and found that the greenery value of 0.59 of the developed method was the highest compared to other reported methods. Still, all were greener and very close to each other. Therefore, the proposed method could be highly recommended to determine RPG from different sources, likely in API and pharmaceutical formulations."/> <meta property="og:image" content="https://static-content.springer.com/image/art%3A10.1007%2Fs42250-024-01131-w/MediaObjects/42250_2024_1131_Fig1_HTML.png"/> <meta name="format-detection" content="telephone=no"> <link rel="apple-touch-icon" sizes="180x180" href=/oscar-static/img/favicons/darwin/apple-touch-icon-92e819bf8a.png> <link rel="icon" type="image/png" sizes="192x192" href=/oscar-static/img/favicons/darwin/android-chrome-192x192-6f081ca7e5.png> <link rel="icon" type="image/png" sizes="32x32" href=/oscar-static/img/favicons/darwin/favicon-32x32-1435da3e82.png> <link rel="icon" type="image/png" sizes="16x16" href=/oscar-static/img/favicons/darwin/favicon-16x16-ed57f42bd2.png> <link rel="shortcut icon" data-test="shortcut-icon" href=/oscar-static/img/favicons/darwin/favicon-c6d59aafac.ico> <meta name="theme-color" content="#e6e6e6">  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The current investigation determined RPG based on the drug’s reaction with potassium permanganate (KMnO4) in an alkaline medium using visible spectrophotometry at 602 nm. The Taguchi model has evaluated the most influential variables, such as reaction time (min), temperature (ºC), KMnO4 concentration (M) and RPG concentration (M), among the preferable parameters estimated by the Fishbone diagram. The setting conditions were optimized as reaction time (10 min), temperature (28º), KMnO4 concentration (2.4 × 10− 2 M) and RPG concentration (2.5 × 10− 2 M) with a constant alkaline solution (1 × 10− 2 M) by Box-Behnken design (BBD) combined response surface methodology (RSM). The current approach not only reduced the amount of reagents or solvents but also supported lowering the analysis time and, ultimately, the project cost. The method was validated as per the ICH guidelines. The linearity was in the range of 2–33.5 µg/mL with LOD and LOQ values of 0.85 and 2.58 µg/mL, respectively. 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Alahmari</a><sup class="u-js-hide"><a href="#Aff3">3</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Mahboob-Alam-Aff4" data-author-popup="auth-Mahboob-Alam-Aff4" data-author-search="Alam, Mahboob">Mahboob Alam</a><sup class="u-js-hide"><a href="#Aff4">4</a></sup> & </li><li class="c-article-author-list__show-more" aria-label="Show all 7 authors for this article" title="Show all 7 authors for this article">…</li><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Rakesh_Roshan-Jha-Aff5" data-author-popup="auth-Rakesh_Roshan-Jha-Aff5" data-author-search="Jha, Rakesh Roshan">Rakesh Roshan Jha</a><sup class="u-js-hide"><a href="#Aff5">5</a></sup> </li></ul><button aria-expanded="false" class="c-article-author-list__button"><svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-chevron-down-medium"></use></svg><span>Show authors</span></button> <div data-test="article-metrics"> <ul class="app-article-metrics-bar u-list-reset"> </ul> </div> <div class="u-mt-32"> </div> </header> </div> <div data-article-body="true" data-track-component="article body" class="c-article-body"> <section aria-labelledby="Abs1" data-title="Abstract" lang="en"><div class="c-article-section" id="Abs1-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Abs1">Abstract</h2><div class="c-article-section__content" id="Abs1-content"><p>Repaglinide (RPG) is appropriate for meglitinides, which screen for rapid insulin secretagogue action to target postprandial hyperglycemia and is preferable to treat type-2 diabetes. The current investigation determined RPG based on the drug’s reaction with potassium permanganate (KMnO<sub>4</sub>) in an alkaline medium using visible spectrophotometry at 602 nm. The Taguchi model has evaluated the most influential variables, such as reaction time (min), temperature (ºC), KMnO<sub>4</sub> concentration (M) and RPG concentration (M), among the preferable parameters estimated by the Fishbone diagram. The setting conditions were optimized as reaction time (10 min), temperature (28º), KMnO<sub>4</sub> concentration (2.4 × 10<sup>− 2</sup> M) and RPG concentration (2.5 × 10<sup>− 2</sup> M) with a constant alkaline solution (1 × 10<sup>− 2</sup> M) by Box-Behnken design (BBD) combined response surface methodology (RSM). The current approach not only reduced the amount of reagents or solvents but also supported lowering the analysis time and, ultimately, the project cost. The method was validated as per the ICH guidelines. The linearity was in the range of 2–33.5 µg/mL with LOD and LOQ values of 0.85 and 2.58 µg/mL, respectively. The accuracy and precision results were well organised, and %RSD was within ± 2% and % recovery between 99.11 and 99.89%. The AGREE algorithm determined the greenery value in pictograms for reported and proposed procedures and found that the greenery value of 0.59 of the developed method was the highest compared to other reported methods. Still, all were greener and very close to each other. Therefore, the proposed method could be highly recommended to determine RPG from different sources, likely in API and pharmaceutical formulations.</p></div></div></section> <div class="c-notes"> <p class="c-notes__text c-status-message--info"> <svg width="24" height="24" focusable="false" role="img" aria-hidden="true" class="c-status-message__icon"> <use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-info-filled-medium"></use> </svg> This is a preview of subscription content, <a id="test-login-banner-link" href="//wayf.springernature.com?redirect_uri=https%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs42250-024-01131-w%3Ferror%3Dcookies_not_supported%26code%3D9e66f68b-8cae-44f2-879c-55997ee7fcfd" data-track="click" data-track-action="login" data-track-label="link" class="c-preview-message__link">log in via an institution</a> <svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon c-external-link__icon"> <use 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data-test="figure-caption-text">Fig. 7</b></figcaption><div class="c-article-section__figure-content"><div class="c-article-section__figure-item"><picture><source type="image/webp" srcset="//media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs42250-024-01131-w/MediaObjects/42250_2024_1131_Fig7_HTML.png?as=webp"><img src="//media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs42250-024-01131-w/MediaObjects/42250_2024_1131_Fig7_HTML.png" alt="" loading="lazy" width="312" height="149"></picture></div></div></figure></div><div class="c-article-section__figure js-c-reading-companion-figures-item" data-test="figure" data-container-section="figure" id="figure-8"><figure><figcaption><b id="Fig8" class="c-article-section__figure-caption" data-test="figure-caption-text">Fig. 8</b></figcaption><div class="c-article-section__figure-content"><div class="c-article-section__figure-item"><picture><source type="image/webp" srcset="//media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs42250-024-01131-w/MediaObjects/42250_2024_1131_Fig8_HTML.png?as=webp"><img src="//media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs42250-024-01131-w/MediaObjects/42250_2024_1131_Fig8_HTML.png" alt="" loading="lazy" width="312" height="254"></picture></div></div></figure></div><div class="c-article-section__figure js-c-reading-companion-figures-item" data-test="figure" data-container-section="figure" id="figure-9"><figure><figcaption><b id="Fig9" class="c-article-section__figure-caption" data-test="figure-caption-text">Fig. 9</b></figcaption><div class="c-article-section__figure-content"><div class="c-article-section__figure-item"><picture><source type="image/webp" srcset="//media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs42250-024-01131-w/MediaObjects/42250_2024_1131_Fig9_HTML.png?as=webp"><img src="//media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs42250-024-01131-w/MediaObjects/42250_2024_1131_Fig9_HTML.png" alt="" loading="lazy" width="312" height="207"></picture></div></div></figure></div><div class="c-article-section__figure js-c-reading-companion-figures-item" data-test="figure" data-container-section="figure" id="figure-10"><figure><figcaption><b id="Fig10" class="c-article-section__figure-caption" data-test="figure-caption-text">Fig. 10</b></figcaption><div class="c-article-section__figure-content"><div class="c-article-section__figure-item"><picture><source type="image/webp" srcset="//media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs42250-024-01131-w/MediaObjects/42250_2024_1131_Fig10_HTML.png?as=webp"><img src="//media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs42250-024-01131-w/MediaObjects/42250_2024_1131_Fig10_HTML.png" alt="" loading="lazy" width="312" height="256"></picture></div></div></figure></div><div class="c-article-section__figure js-c-reading-companion-figures-item" data-test="figure" data-container-section="figure" id="figure-11"><figure><figcaption><b id="Fig11" class="c-article-section__figure-caption" data-test="figure-caption-text">Fig. 11</b></figcaption><div class="c-article-section__figure-content"><div class="c-article-section__figure-item"><picture><source type="image/webp" srcset="//media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs42250-024-01131-w/MediaObjects/42250_2024_1131_Fig11_HTML.png?as=webp"><img src="//media.springernature.com/m312/springer-static/image/art%3A10.1007%2Fs42250-024-01131-w/MediaObjects/42250_2024_1131_Fig11_HTML.png" alt="" loading="lazy" width="312" height="166"></picture></div></div></figure></div> </div> <div data-test="cobranding-download"> </div> <section data-title="Data availability"><div class="c-article-section" id="data-availability-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="data-availability">Data availability</h2><div class="c-article-section__content" id="data-availability-content"> <p>All data generated or analyzed in this study is included in published article (and its supplementary files).</p> </div></div></section><div id="MagazineFulltextArticleBodySuffix"><section aria-labelledby="Bib1" data-title="References"><div class="c-article-section" id="Bib1-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Bib1">References</h2><div class="c-article-section__content" id="Bib1-content"><div data-container-section="references"><ol class="c-article-references" data-track-component="outbound reference" data-track-context="references section"><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="1."><p class="c-article-references__text" id="ref-CR1">Kristina A et al (2021) Prevalence of arthritis and arthritis– attributablet activity limitation–United States, 2016–2018. 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J Epidemiol Glob Health 10:107–111. <a href="https://doi.org/10.2991/jegh.k.191028.001" data-track="click_references" data-track-action="external reference" data-track-value="external reference" data-track-label="10.2991/jegh.k.191028.001">https://doi.org/10.2991/jegh.k.191028.001</a></p></li><li class="c-article-references__item js-c-reading-companion-references-item" data-counter="3."><p class="c-article-references__text" id="ref-CR3">Katie, deL et al (2022) Disability burden due to musculoskeletal conditions and low back pain in Australia: findings from GBD 2019. 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FABAD J Pharm Sci 35:69–75</p></li></ol><p class="c-article-references__download u-hide-print"><a data-track="click" data-track-action="download citation references" data-track-label="link" rel="nofollow" href="https://citation-needed.springer.com/v2/references/10.1007/s42250-024-01131-w?format=refman&flavour=references">Download references<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-download-medium"></use></svg></a></p></div></div></div></section></div><section data-title="Funding"><div class="c-article-section" id="Fun-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Fun">Funding</h2><div class="c-article-section__content" id="Fun-content"><p>This research did not obtain any financial grant to complete the work.</p></div></div></section><section aria-labelledby="author-information" data-title="Author information"><div class="c-article-section" id="author-information-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="author-information">Author information</h2><div class="c-article-section__content" id="author-information-content"><h3 class="c-article__sub-heading" id="affiliations">Authors and Affiliations</h3><ol class="c-article-author-affiliation__list"><li id="Aff1"><p class="c-article-author-affiliation__address">Department of Chemical Engineering, Jubail Industrial College, Jubail Industrial City, 31961, Saudi Arabia</p><p class="c-article-author-affiliation__authors-list">SK Manirul Haque, Yunusa Umar & Ahmed Abu Judeh</p></li><li id="Aff2"><p class="c-article-author-affiliation__address">Central Forensic Science Laboratory, Forensic Toxicology Division, Plot #2, Sector 36-A, Dakshin Marg, Chandigarh, 160036, India</p><p class="c-article-author-affiliation__authors-list">Rajeev Jain</p></li><li id="Aff3"><p class="c-article-author-affiliation__address">Department of Chemistry, Faculty of Science, Jazan University, P.O. 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Alahmari</p></li><li id="Aff4"><p class="c-article-author-affiliation__address">Division of Chemistry and Biotechnology, Dongguk Wise University, 123 Dongdae-Ro, Gyeongju, 780714, Republic of Korea</p><p class="c-article-author-affiliation__authors-list">Mahboob Alam</p></li><li id="Aff5"><p class="c-article-author-affiliation__address">Centre of Analytical Biosciences, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK</p><p class="c-article-author-affiliation__authors-list">Rakesh Roshan Jha</p></li></ol><div class="u-js-hide u-hide-print" data-test="author-info"><span class="c-article__sub-heading">Authors</span><ol class="c-article-authors-search u-list-reset"><li id="auth-SK_Manirul-Haque-Aff1"><span class="c-article-authors-search__title u-h3 js-search-name">SK Manirul Haque</span><div class="c-article-authors-search__list"><div class="c-article-authors-search__item c-article-authors-search__list-item--left"><a href="/search?dc.creator=SK%20Manirul%20Haque" class="c-article-button" data-track="click" data-track-action="author link - 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id="citeas">Cite this article</h3><p class="c-bibliographic-information__citation">Haque, S.M., Jain, R., Umar, Y. <i>et al.</i> Design of Experiment (DoE), Screening and Optimization of System Variables to Develop and Validate Greener Spectrophotometric Investigation of Repaglinide. <i>Chemistry Africa</i> (2024). https://doi.org/10.1007/s42250-024-01131-w</p><p class="c-bibliographic-information__download-citation u-hide-print"><a data-test="citation-link" data-track="click" data-track-action="download article citation" data-track-label="link" data-track-external="" rel="nofollow" href="https://citation-needed.springer.com/v2/references/10.1007/s42250-024-01131-w?format=refman&flavour=citation">Download citation<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-download-medium"></use></svg></a></p><ul class="c-bibliographic-information__list" data-test="publication-history"><li class="c-bibliographic-information__list-item"><p>Received<span class="u-hide">: </span><span class="c-bibliographic-information__value"><time datetime="2024-09-23">23 September 2024</time></span></p></li><li class="c-bibliographic-information__list-item"><p>Accepted<span class="u-hide">: </span><span class="c-bibliographic-information__value"><time datetime="2024-11-03">03 November 2024</time></span></p></li><li class="c-bibliographic-information__list-item"><p>Published<span class="u-hide">: </span><span class="c-bibliographic-information__value"><time datetime="2024-11-22">22 November 2024</time></span></p></li><li class="c-bibliographic-information__list-item c-bibliographic-information__list-item--full-width"><p><abbr title="Digital Object Identifier">DOI</abbr><span class="u-hide">: </span><span class="c-bibliographic-information__value">https://doi.org/10.1007/s42250-024-01131-w</span></p></li></ul><div data-component="share-box"><div 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data-track-action="view keyword" data-track-label="link">BBD-RSM</a></span></li><li class="c-article-subject-list__subject"><span><a href="/search?query=Fishbone%20diagram&facet-discipline="Chemistry"" data-track="click" data-track-action="view keyword" data-track-label="link">Fishbone diagram</a></span></li><li class="c-article-subject-list__subject"><span><a href="/search?query=Validation&facet-discipline="Chemistry"" data-track="click" data-track-action="view keyword" data-track-label="link">Validation</a></span></li><li class="c-article-subject-list__subject"><span><a href="/search?query=White%20analytical%20chemistry&facet-discipline="Chemistry"" data-track="click" data-track-action="view keyword" data-track-label="link">White analytical chemistry</a></span></li><li class="c-article-subject-list__subject"><span><a href="/search?query=AGREE&facet-discipline="Chemistry"" data-track="click" data-track-action="view keyword" data-track-label="link">AGREE</a></span></li></ul><div 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