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et-l--post"> <div class="et_builder_inner_content et_pb_gutters2"> <div class="et_pb_section et_pb_section_0 et_pb_section_video et_pb_preload et_pb_with_background et_pb_section_parallax et_section_regular" > <span class="et_pb_section_video_bg "> <video loop="loop" autoplay playsinline muted > <source type="video/mp4" src="https://www.dynamic-biosensors.com/wpcms/wp-content/uploads/Discover-Molecular-Interactions.mov" /> </video> </span> <div class="et_pb_row et_pb_row_0"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_0 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><p style="text-align: center;"><span style="color: #ffffff;">DISCOVER</span><br /><span style="color: #ffffff;">MOLECULAR<br />INTERACTIONS</span></p></div> </div> </div> </div><div class="et_pb_row et_pb_row_1"> <div class="et_pb_column et_pb_column_1_2 et_pb_column_1 et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_button_module_wrapper et_pb_button_0_wrapper et_pb_button_alignment_center et_pb_module "> <a class="et_pb_button et_pb_button_0 et_animated et_hover_enabled et_pb_bg_layout_light" href="https://www.dynamic-biosensors.com/switchsense/" target="_blank">MOLECULE-MOLECULE INTERACTIONS</a> </div> </div><div class="et_pb_column et_pb_column_1_2 et_pb_column_2 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_button_module_wrapper et_pb_button_1_wrapper et_pb_button_alignment_center et_pb_module "> <a class="et_pb_button et_pb_button_1 et_animated et_hover_enabled et_pb_bg_layout_light" href="https://www.dynamic-biosensors.com/rt-ic/" target="_blank">MOLECULE-CELL INTERACTIONS</a> </div> </div> </div> </div><div id="switchSENSE" class="et_pb_section et_pb_section_1 et_pb_with_background et_section_regular" > <div class="et_pb_row et_pb_row_2"> <div class="et_pb_column et_pb_column_1_4 et_pb_column_3 et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_module et_pb_text et_pb_text_1 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner" data-et-multi-view="{"schema":{"content":{"desktop":"<blockquote>\n<h2><span style=\"font-size: large;\"><span style=\"color: #009fe3;\"><strong>DISCOVER <\/strong><span style=\"color: #3f4d61;\"><strong>MOLECULAR INTERACTIONS<\/strong> using the <strong>heli<\/strong><\/span><strong>X<\/strong><\/span><sup>\u00ae\u00a0<\/sup> platform \u2013 versatile assay formats for comprehensive biophysical information.<\/span><\/h2>\n<p>\u2192 <strong><a href=\"https:\/\/www.dynamic-biosensors.com\/switchsense\/\" target=\"_blank\" rel=\"noopener noreferrer\">LEARN MORE<\/a><\/strong><\/p>\n<\/blockquote>","tablet":"<blockquote>\n<h2><span style=\"font-size: large;\"><span style=\"color: #009fe3;\"><strong>DISCOVER <\/strong><span style=\"color: #3f4d61;\"><strong>MOLECULAR INTERACTIONS<\/strong> using the <strong>heli<\/strong><\/span><strong>X<\/strong><\/span><sup>\u00ae <\/sup> platform \u2013 versatile assay formats for comprehensive biophysical information.<\/span><\/h2>\n<p>\u2192 <a href=\"https:\/\/www.dynamic-biosensors.com\/switchsense\/\" target=\"_blank\" rel=\"noopener noreferrer\">LEARN MORE<\/a><\/p>\n<\/blockquote>"}},"slug":"et_pb_text"}" data-et-multi-view-load-tablet-hidden="true"><blockquote> <h2><span style="font-size: large;"><span style="color: #009fe3;"><strong>DISCOVER </strong><span style="color: #3f4d61;"><strong>MOLECULAR INTERACTIONS</strong> using the <strong>heli</strong></span><strong>X</strong></span><sup>® </sup> platform – versatile assay formats for comprehensive biophysical information.</span></h2> <p>→ <strong><a href="https://www.dynamic-biosensors.com/switchsense/" target="_blank" rel="noopener noreferrer">LEARN MORE</a></strong></p> </blockquote></div> </div> </div><div class="et_pb_column et_pb_column_3_4 et_pb_column_4 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_text et_pb_text_2 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><p style="text-align: justify;">Every day, scientists all over the world strive to unravel the secrets of life. How do diseases develop? How can we treat them? In order to answer these big questions, we need to start small. We need to understand the tiny building blocks: molecules. How big are they? What is their structure? How do they interact with each other? The answers to these questions will guide us towards new and improved medicines to treat diseases like cancer.</p> <p style="text-align: justify;">At Dynamic Biosensors, we have made it our mission to support scientists in this endeavor and to help accelerate the drug discovery process.</p> <p style="text-align: justify;">To fulfil this, we developed <span style="color: #009fe3;"><strong>switch</strong></span>SENSE<sup>®</sup> and <strong>single-cell Interaction Cytometry </strong>(<span style="color: #009fe3;"><strong>scIC</strong></span>) <span class="TextRun SCXP8273136 BCX9" lang="EN-US" xml:lang="EN-US" data-scheme-color="@3F4D61,3," data-usefontface="true" data-contrast="none"><span class="NormalTextRun SCXP8273136 BCX9">– two groundbreaking technologies that enable researchers </span></span><span class="TextRun SCXP8273136 BCX9" lang="EN-US" xml:lang="EN-US" data-scheme-color="@3F4D61,3," data-usefontface="true" data-contrast="none"><span class="NormalTextRun SCXP8273136 BCX9">to characterize molecular interactions in unequaled detail.</span></span><span class="EOP SCXP8273136 BCX9"></span><sup> </sup></p> <p style="text-align: justify;"></div> </div> </div> </div> </div><div class="et_pb_section et_pb_section_2 et_pb_fullwidth_section et_section_regular" > <div class="et_pb_module et_pb_fullwidth_image et_pb_fullwidth_image_0"> </div> </div><div class="et_pb_section et_pb_section_3 et_section_regular" > <div class="et_pb_row et_pb_row_3"> <div class="et_pb_column et_pb_column_1_4 et_pb_column_5 et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_module et_pb_cta_0 et_hover_enabled et_clickable et_pb_section_video_on_hover et_pb_section_parallax_hover et_pb_promo et_pb_text_align_left et_pb_bg_layout_dark et_pb_no_bg"> <div class="et_pb_promo_description"><h2 class="et_pb_module_header">VIROLOGY</h2></div> </div> </div><div class="et_pb_column et_pb_column_1_4 et_pb_column_6 et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_module et_pb_cta_1 et_hover_enabled et_clickable et_pb_section_video_on_hover et_pb_section_parallax_hover et_pb_promo et_pb_text_align_left et_pb_bg_layout_dark et_pb_no_bg"> <div class="et_pb_promo_description"><h2 class="et_pb_module_header">IMMUNOTHERAPY</h2></div> </div> </div><div class="et_pb_column et_pb_column_1_4 et_pb_column_7 et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_module et_pb_cta_2 et_hover_enabled et_clickable et_pb_section_video_on_hover et_pb_section_parallax_hover et_pb_promo et_pb_text_align_left et_pb_bg_layout_dark et_pb_no_bg"> <div class="et_pb_promo_description"><h2 class="et_pb_module_header">ONCOLOGY</h2></div> </div> </div><div class="et_pb_column et_pb_column_1_4 et_pb_column_8 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_cta_3 et_hover_enabled et_clickable et_pb_section_video_on_hover et_pb_section_parallax_hover et_pb_promo et_pb_text_align_left et_pb_bg_layout_dark et_pb_no_bg"> <div class="et_pb_promo_description"><h2 class="et_pb_module_header">DRUG DISCOVERY & UNDRUGGABLE TARGETS</h2></div> </div> </div> </div><div class="et_pb_row et_pb_row_4"> <div class="et_pb_column et_pb_column_1_4 et_pb_column_9 et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_module et_pb_cta_4 et_hover_enabled et_clickable et_pb_section_video_on_hover et_pb_section_parallax_hover et_pb_promo et_pb_text_align_left et_pb_bg_layout_dark et_pb_no_bg"> <div class="et_pb_promo_description"><h2 class="et_pb_module_header">NEUROLOGICAL DISEASES</h2></div> </div> </div><div class="et_pb_column et_pb_column_1_4 et_pb_column_10 et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_module et_pb_cta_5 et_hover_enabled et_clickable et_pb_section_video_on_hover et_pb_section_parallax_hover et_pb_promo et_pb_text_align_left et_pb_bg_layout_dark et_pb_no_bg"> <div class="et_pb_promo_description"><h2 class="et_pb_module_header">ENVIRONMENTAL TOXICOLOGY</h2></div> </div> </div><div class="et_pb_column et_pb_column_1_4 et_pb_column_11 et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_module et_pb_cta_6 et_hover_enabled et_clickable et_pb_section_video_on_hover et_pb_section_parallax_hover et_pb_promo et_pb_text_align_left et_pb_bg_layout_dark et_pb_no_bg"> <div class="et_pb_promo_description"><h2 class="et_pb_module_header">RESEARCH TECHNOLOGY ADVANCES </h2></div> </div> </div><div class="et_pb_column et_pb_column_1_4 et_pb_column_12 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_cta_7 et_hover_enabled et_clickable et_pb_section_video_on_hover et_pb_section_parallax_hover et_pb_promo et_pb_text_align_left et_pb_bg_layout_dark et_pb_no_bg"> <div class="et_pb_promo_description"><h2 class="et_pb_module_header">BACTERIA</h2></div> </div> </div> </div> </div><div id="#overview" class="et_pb_section et_pb_section_4 et_section_regular" > <div class="et_pb_row et_pb_row_5"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_13 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_text et_pb_text_3 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><p><strong><span style="font-size: medium;"><span style="color: #009fe3;">dynamic</span></span></strong><span style="font-size: medium;">BIOSENSORS</span><strong><span style="font-size: medium;"> technologies for molecular interaction analysis </span></strong><span style="font-size: medium;">feature</span><strong><span style="font-size: medium;"> unparalleled analytical capabilities</span></strong><span style="font-size: medium;">, enabling the development and manufacturing of future drugs. </span></p></div> </div><div class="et_pb_module et_pb_image et_pb_image_0"> <a href="https://www.dynamic-biosensors.com/wpcms/wp-content/uploads/Bruker-Biosensors-1.png" class="et_pb_lightbox_image" title=""><span class="et_pb_image_wrap "><img fetchpriority="high" decoding="async" width="4148" height="1350" src="https://www.dynamic-biosensors.com/wpcms/wp-content/uploads/Bruker-Biosensors-1.png" alt="" title="Bruker Biosensors" srcset="https://www.dynamic-biosensors.com/wpcms/wp-content/uploads/Bruker-Biosensors-1.png 4148w, https://www.dynamic-biosensors.com/wpcms/wp-content/uploads/Bruker-Biosensors-1-1280x417.png 1280w, https://www.dynamic-biosensors.com/wpcms/wp-content/uploads/Bruker-Biosensors-1-980x319.png 980w, https://www.dynamic-biosensors.com/wpcms/wp-content/uploads/Bruker-Biosensors-1-480x156.png 480w" sizes="(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) and (max-width: 1280px) 1280px, (min-width: 1281px) 4148px, 100vw" class="wp-image-50246" /></span></a> </div> </div> </div><div class="et_pb_row et_pb_row_6"> <div class="et_pb_column et_pb_column_1_3 et_pb_column_14 et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_module et_pb_text et_pb_text_4 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h2><strong>Our<br />Products </strong></h2></div> </div><div class="et_pb_module et_pb_divider et_pb_divider_0 et_animated et_pb_divider_position_ et_pb_space"><div class="et_pb_divider_internal"></div></div><div class="et_pb_module et_pb_text et_pb_text_5 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><p><span style="font-size: x-large;"><strong>Made for </strong></span><strong style="font-size: x-large;"><span style="color: #009fe3;">high-performance </span>analysis.</strong></p></div> </div> </div><div class="et_pb_column et_pb_column_2_3 et_pb_column_15 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_accordion et_pb_accordion_0"> <div class="et_pb_toggle et_pb_module et_pb_accordion_item et_pb_accordion_item_0 et_pb_toggle_open"> <h5 class="et_pb_toggle_title">MOLECULE-MOLECULE INTERACTIONS</h5> <div class="et_pb_toggle_content clearfix"><p style="text-align: left;"><span style="font-size: medium;"><span style="color: #3f4d61;">→<a href="https://www.dynamic-biosensors.com/switchsense/" target="_blank" rel="noopener"> <b><span style="color: #009fe3;"><strong>switch</strong></span></b>SENSE<sup>® </sup></a></span></span><a href="https://www.dynamic-biosensors.com/switchsense/" target="_blank" rel="noopener"><strong>technology</strong></a><span style="font-size: medium;"><span style="color: #3f4d61;"><sup></sup></span></span></p> <p style="text-align: left;">→ <span style="font-size: medium;"><span style="color: #3f4d61;"><a href="https://www.dynamic-biosensors.com/helix/" target="_blank" rel="noopener"><b>heli<span style="color: #009fe3;">X</span> / heli<span style="color: #009fe3;">X</span></b><strong><sup>+</sup></strong> <strong>biosensor instruments </strong></a>(<strong><b><span style="color: #009fe3;">switch</span></b></strong>SENSE<sup>® </sup>compatible)</span></span></p> <p style="text-align: left;">→ <span style="font-size: medium;"><span style="color: #3f4d61;"><a href="https://www.dynamic-biosensors.com/helix-chip/" target="_blank" rel="noopener"><b>heli<span style="color: #009fe3;">X</span> </b></a><strong><a href="https://www.dynamic-biosensors.com/helix-chip/" target="_blank" rel="noopener">chip</a><br /></strong></span></span><span style="font-size: medium;"><span style="color: #3f4d61;"></span></span></p> <p style="text-align: left;">→<span style="font-size: medium;"><span style="color: #3f4d61;"><b> </b></span></span><a href="https://www.dynamic-biosensors.com/helix-consumables/" target="_blank" rel="noopener"><span style="font-size: medium;"><b>Consumables</b></span></a><span style="font-size: medium;"><span style="color: #3f4d61;"><strong></strong></span></span><span style="font-size: medium;"><span style="color: #3f4d61;"><b></b></span></span><span style="font-size: medium;"><span style="color: #3f4d61;"><b></b></span></span><span style="font-size: medium;"><span style="color: #3f4d61;"><b></b></span></span></p> <p style="text-align: left;"><span style="font-size: medium;"><span style="color: #3f4d61;"><b>→ <a href="https://www.dynamic-biosensors.com/helios-download-2022-4/" target="_blank" rel="noopener">heli<span style="color: #009fe3;">OS</span> <strong>software</strong></a></b></span></span></p></div> </div><div class="et_pb_toggle et_pb_module et_pb_accordion_item et_pb_accordion_item_1 et_pb_toggle_close"> <h5 class="et_pb_toggle_title">MOLECULE-CELL INTERACTIONS</h5> <div class="et_pb_toggle_content clearfix"><p><span>→<a href="https://www.dynamic-biosensors.com/rt-ic/" target="_blank" rel="noopener"> <b>scIC </b><sup></sup></a></span><a href="https://www.dynamic-biosensors.com/rt-ic/" target="_blank" rel="noopener"><strong>technology</strong></a><span><sup></sup></span></p> <p>→<span> </span><span><a href="https://www.dynamic-biosensors.com/helixcyto/" target="_blank" rel="noopener"><b>heliX</b><strong><sup>cyto</sup></strong> <strong>instrument </strong></a>(<span style="font-size: medium;"><span style="color: #3f4d61;"><strong><b><span style="color: #009fe3;">scIC</span></b></strong></span></span><sup> </sup>compatible)</span></p> <p>→<span> </span><a href="https://www.dynamic-biosensors.com/helixcyto-chip/" target="_blank" rel="noopener"><span><b>heliX</b><strong><sup>cyto</sup></strong></span><span><b> </b><strong>chip</strong></span></a><span></span><span><strong></strong></span></p> <p><span><b>→ <a href="https://www.dynamic-biosensors.com/helios-download-2022-4/" target="_blank" rel="noopener">heliOS <strong>software</strong></a></b></span></p></div> </div><div class="et_pb_toggle et_pb_module et_pb_accordion_item et_pb_accordion_item_2 et_pb_toggle_close"> <h5 class="et_pb_toggle_title">PURE PROTEIN-DNA CONJUGATES</h5> <div class="et_pb_toggle_content clearfix"><p style="text-align: left;">→ <a href="https://www.dynamic-biosensors.com/profire/" target="_blank" rel="noopener"><span style="font-size: medium;"><strong>pro</strong>FIRE</span><span style="font-size: medium;"><strong><sup>®</sup></strong> <strong>instrument </strong></span></a></p> <p style="text-align: left;">→ <a href="https://www.dynamic-biosensors.com/antibody-oligonucleotide-conjugation/" target="_blank" rel="noopener"><strong>Antibody-oligonucleotide conjugation</strong></a></p> <p style="text-align: left;"><span style="font-size: medium;"><span style="color: #3f4d61;"><b>→ <a href="https://www.dynamic-biosensors.com/his-tagged-proteins-conjugation/" target="_blank" rel="noopener">His-tagged proteins conjugation</a></b></span></span></p></div> </div> </div> </div> </div> </div><div class="et_pb_section et_pb_section_5 et_pb_with_background et_section_regular" > <div class="et_pb_row et_pb_row_7"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_16 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_text et_pb_text_6 statement_quote_text et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><p style="text-align: center;"><span style="font-weight: 500;"><br /><span class="openquote">„</span><a href="https://www.dynamic-biosensors.com/wpcms/user-statements/"><span style="color: #000000;">Until recently I always said, unfortunately we cannot do that on cells, k<sub>on</sub> and k<sub>off</sub>. A great answer now is with the <strong>heli</strong></span></a><strong><a href="https://www.dynamic-biosensors.com/wpcms/user-statements/"><span style="color: #009fe3;">X</span></a></strong><sup>cyto</sup> we can. I like that a lot. Because this is really new and gives us new information</span><span style="color: #000000;">.</span><span class="closequote">“</span></p></div> </div><div class="et_pb_module et_pb_text et_pb_text_7 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><p style="text-align: center;">Prof. Harald Kolmar, Kolmar Group<br />TU DARMSTADT</p></div> </div> </div> </div> </div><div id="applications" class="et_pb_section et_pb_section_6 et_pb_with_background et_section_specialty" > <div class="et_pb_row"> <div class="et_pb_column et_pb_column_1_3 et_pb_column_17 et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_module et_pb_text et_pb_text_8 et_animated et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h2><span style="color: #3f4d61;"><strong><span style="color: #3f4d61;">In <span style="color: #009fe3;">focus</span>. </span></strong></span></h2></div> </div><div class="et_pb_module et_pb_divider et_pb_divider_1 et_animated et_pb_divider_position_ et_pb_space"><div class="et_pb_divider_internal"></div></div><div class="et_pb_module et_pb_text et_pb_text_9 et_animated et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h2><span style="color: #3f4d61;">Browse through the latest publications.</span></h2></div> </div> </div><div class="et_pb_column et_pb_column_2_3 et_pb_column_18 et_pb_specialty_column et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_row_inner et_pb_row_inner_0"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_inner et_pb_column_inner_0 et-last-child"> <div class="et_pb_module et_pb_accordion et_pb_accordion_1"> <div class="et_pb_toggle et_pb_module et_pb_accordion_item et_pb_accordion_item_3 et_pb_toggle_open"> <h5 class="et_pb_toggle_title">New publication in antibodies I 2 May 2024 (open access) </h5> <div class="et_pb_toggle_content clearfix"><h3 class="c-article-title" data-test="article-title"><a href="https://www.mdpi.com/2073-4468/13/2/36" target="_blank" rel="noopener">Balancing the Affinity and Tumor Cell Binding of a Two-in-One Antibody Simultaneously Targeting EGFR and PD-L1</a></h3> <p><span><span class="ui-provider bdn bdo bdp bdq bdr bds bdt bdu bdv bdw bdx bdy bdz bea beb bec bed bee bef beg beh bei bej bek bel bem ben beo bep beq ber bes bet beu bev" dir="ltr">Congratulations to <a href="https://www.linkedin.com/in/julia-harwardt-24462a207/" target="_blank" rel="noopener">Julia Harwardt</a> and our collaborators from <a href="https://www.chemie.tu-darmstadt.de/kolmar/ueber_uns_hk/index.en.jsp" target="_blank" rel="noopener"> Harald Kolmar</a>‘s lab </span></span>for their recent publication in antibodies!<br />The publication is about a specific type of symmetric bispecific antibodies called Two-in-One antibodies. The authors investigated whether affinity maturation for one target molecule (in this case EGFR) can be done without affecting the affinity for the second target molecule (in this case PD-L1). They compared mutated antibody variants with the wildtype antibody. They measured the binding kinetics of the antibodies to both targets simultaneously with <span style="color: #009fe3;"><strong>switch</strong></span>SENSE<sup>®</sup>. Here, they made use of the technology’s unique capability to<strong> immobilize both target proteins</strong> on the surface at the same time in a <strong>controlled density</strong> and to perform <strong>dual-color</strong> measurements. This allowed them to investigate the influence of the two binding partners on each other. Moreover, they used <span style="color: #009fe3;"><strong>RT-IC</strong></span> to measure the real-time binding kinetics of the antibody variants directly on double-positive tumor cell lines. They showed that especially the dissociation rate was reduced and thus antibody variants had a longer retention time on the cell surface.</p> <p><a href="https://www.mdpi.com/2073-4468/13/2/36" target="_blank" rel="noopener"><b>READ MORE</b></a></p></div> </div><div class="et_pb_toggle et_pb_module et_pb_accordion_item et_pb_accordion_item_4 et_pb_toggle_close"> <h5 class="et_pb_toggle_title">New publication in the RSC Chemical Biology journal I 23 April 2024 (open access) </h5> <div class="et_pb_toggle_content clearfix"><h3 class="c-article-title" data-test="article-title"><a href="https://pubs.rsc.org/en/content/articlelanding/2024/cb/d4cb00084f" target="_blank" rel="noopener">Reverse transcription as key step in RNA in vitro evolution with unnatural base pairs</a></h3> <p><span><span class="ui-provider bdn bdo bdp bdq bdr bds bdt bdu bdv bdw bdx bdy bdz bea beb bec bed bee bef beg beh bei bej bek bel bem ben beo bep beq ber bes bet beu bev" dir="ltr">Congratulations to <a href="https://www.linkedin.com/in/eva-hoffmann-103928223/" target="_blank" rel="noopener">Eva Hoffmann</a> and our collaborators from <a href="https://www.linkedin.com/in/stephanie-kath-schorr-839900141/" target="_blank" rel="noopener"> Stephanie Kath-Schorr</a>‘s lab </span></span>for their insightful publication in RSC Chemical Biology!<br />They explored different reverse transcriptases and how they can be used to expand the genetic alphabet with unnatural bases. switchSENSE was used to monitor the binding affinities as well as the <strong>reverse transcription kinetics</strong> in real time and compare the kinetic efficacy of 2 different transcriptases on 4 different template ligand strands with 6 different natural and unnatural nucleotides. This study showcases that the heliX biosensor can be a powerful tool to study nucleic acid-modifying enzymes like reverse transcriptases and polymerases as it enables the real-time kinetic characterization of <strong>binding as well as activity</strong>.</p> <p><a href="//doi.org/10.1039/D4CB00084F" target="_blank" rel="noopener"><b>READ MORE</b></a></p></div> </div><div class="et_pb_toggle et_pb_module et_pb_accordion_item et_pb_accordion_item_5 et_pb_toggle_close"> <h5 class="et_pb_toggle_title">New publication in eLife I 16 February 2024 (open access) </h5> <div class="et_pb_toggle_content clearfix"><h3 class="c-article-title" data-test="article-title"><a href="https://elifesciences.org/articles/91777" target="_blank" rel="noopener">Repurposing the mammalian RNA-binding protein Musashi-1 as an allosteric translation repressor in bacteria</a></h3> <p><span><span class="ui-provider bdn bdo bdp bdq bdr bds bdt bdu bdv bdw bdx bdy bdz bea beb bec bed bee bef beg beh bei bej bek bel bem ben beo bep beq ber bes bet beu bev" dir="ltr">Congratulations to <a href="https://www.linkedin.com/in/roswitha-dolcemascolo-695a09166/" target="_blank" rel="noopener">Roswitha Dolcemascolo</a> and her co-authors for their publication on RNA-binding proteins in eLife!<br /> The authors established the mammalian RNA-binding protein Musashi-1 (MSI-1) as a tool for synthetic biologists, specifically as a post-transcriptional repressor in E.coli.<br /> <span style="color: #009fe3;"><strong>switch</strong></span>SENSE<sup>®</sup> was used to study binding of this <strong>two-domain RNA binding protein</strong> to RNA ligands and to determine differences between the original RNA binding motif and mutated RNA ligands</span></span></p> <p><a href="https://elifesciences.org/articles/91777" target="_blank" rel="noopener"><b>READ MORE</b></a></div> </div><div class="et_pb_toggle et_pb_module et_pb_accordion_item et_pb_accordion_item_6 et_pb_toggle_close"> <h5 class="et_pb_toggle_title">New publication in the ACS Sensors journal I 7 December 2023 (open access) </h5> <div class="et_pb_toggle_content clearfix"><h3 class="c-article-title" data-test="article-title"><a href="https://doi.org/10.1021/acssensors.3c01527" target="_blank" rel="noopener">Kinetic FRET Assay to Measure Binding-Induced Conformational Changes of Nucleic Acids</a></h3> <p>Congratulations to <a href="https://www.linkedin.com/in/anahi-higuera/">Anahi Higuera-Rodriguez</a> and <a href="https://www.linkedin.com/in/mareike-de-pascali-271a401bb/">Mareike De Pascali</a> for their recent publication in ACS Sensors!</p> <p>They demonstrate the application of <strong>FRET</strong> in kinetic measurements for discerning binding-induced conformational changes in nucleic acids. This cutting-edge technique was applied to two distinct systems: the interaction between DNA and small molecules (MN19 aptamer with quinine) and the interaction between RNA and proteins (IMP3-KH1/2). The entire study was conducted on the <span style="color: #3f4d61;"><strong>heli<span style="color: #009fe3;">X</span></strong><sup>®</sup> platform.</span></p> <p>The paper not only showcases the versatility and efficacy of <strong>FRET</strong> in unraveling intricate molecular dynamics but also sheds light on the specific interactions within the DNA-small molecule and RNA-protein systems studied. This work significantly contributes to our understanding of binding-induced conformational changes in nucleic acids.</p> <p><a href="https://doi.org/10.1021/acssensors.3c01527" target="_blank" rel="noopener"><b>READ MORE</b></a></p></div> </div> </div><div class="et_pb_module et_pb_text et_pb_text_10 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner">→ click<a href="https://www.dynamic-biosensors.com/literature/" target="_blank" rel="noopener noreferrer"><strong><span style="color: #009fe3;"> here</span> </strong></a>for a list of all <span style="color: #009fe3;"><strong>switch</strong></span>SENSE<sup>® </sup>publications.</div> </div> </div> </div> </div> </div> </div><div id="applications" class="et_pb_section et_pb_section_7 et_pb_with_background et_section_specialty" > <div class="et_pb_row"> <div class="et_pb_column et_pb_column_1_3 et_pb_column_19 et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_module et_pb_text et_pb_text_11 et_animated et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><h2><span style="color: #3f4d61;"><strong><span style="color: #3f4d61;"><span style="color: #009fe3;">NEWS</span>. </span></strong></span></h2></div> </div><div class="et_pb_module et_pb_divider et_pb_divider_2 et_animated et_pb_divider_position_ et_pb_space"><div class="et_pb_divider_internal"></div></div> </div><div class="et_pb_column et_pb_column_2_3 et_pb_column_20 et_pb_specialty_column et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_row_inner et_pb_row_inner_1"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_inner et_pb_column_inner_1 et-last-child"> <div class="et_pb_module et_pb_accordion et_pb_accordion_2"> <div class="et_pb_toggle et_pb_module et_pb_accordion_item et_pb_accordion_item_7 et_pb_toggle_open"> <h5 class="et_pb_toggle_title">News Feature | 2 October 2024</h5> <div class="et_pb_toggle_content clearfix"><h3><strong><span class="ui-provider azd aze azf azg azh azi azj azk azl azm azn azo azp azq azr azs azt azu azv azw azx azy azz baa bab bac bae baf bag bah bai baj bak bal bam" dir="ltr"><span data-teams="true"><span class="ui-provider a b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak" dir="ltr">We are excited to announce that Dynamic Biosensors has officially been acquired by Bruker forming the new Bruker Biosensors business!</span></span></span></strong></h3> <p><strong></strong></p> <p><strong>Dynamic Biosensors</strong>’ cutting-edge instruments for comprehensive interaction analyses, the <span style="color: #3f4d61;"><strong>heli<span style="color: #009fe3;">X</span></strong><sup>®</sup> and the <span style="color: #3f4d61;"><strong>heli<span style="color: #009fe3;">X</span></strong><sup>cyto</sup>, perfectly complement Bruker’s leading high-throughput SPR portfolio, including the all-new SPR #64 (‘Triceratops’). This will allow us at <strong>Bruker Biosensors</strong> to cater to all of our customers’ needs for studying molecular interactions – every step of the drug discovery pipeline.</span></span></p> <p>Together, we’re stronger, more innovative, and ready to shape the future of the biosensing industry.</p> <p>Read the full press release here: <a aria-label="Link https://ir.bruker.com/press-releases/press-release-details/2024/Bruker-Acquires-Dynamic-Biosensors-a-Pioneer-of-Single-Cell-Interaction-Cytometry-Systems-for-Drug-Discovery/default.aspx" id="menurh3l" href="https://ir.bruker.com/press-releases/press-release-details/2024/Bruker-Acquires-Dynamic-Biosensors-a-Pioneer-of-Single-Cell-Interaction-Cytometry-Systems-for-Drug-Discovery/default.aspx" rel="noreferrer noopener" target="_blank" class="fui-Link ___1q1shib f2hkw1w f3rmtva f1ewtqcl fyind8e f1k6fduh f1w7gpdv fk6fouc fjoy568 figsok6 f1s184ao f1mk8lai fnbmjn9 f1o700av f13mvf36 f1cmlufx f9n3di6 f1ids18y f1tx3yz7 f1deo86v f1eh06m1 f1iescvh fhgqx19 f1olyrje f1p93eir f1nev41a f1h8hb77 f1lqvz6u f10aw75t fsle3fq f17ae5zn" title="https://ir.bruker.com/press-releases/press-release-details/2024/bruker-acquires-dynamic-biosensors-a-pioneer-of-single-cell-interaction-cytometry-systems-for-drug-discovery/default.aspx">https://ir.bruker.com/press-releases/press-release-details/2024/Bruker-Acquires-Dynamic-Biosensors-a-Pioneer-of-Single-Cell-Interaction-Cytometry-Systems-for-Drug-Discovery/default.aspx</a></p> <p>and stay tuned for more updates on this journey!</p></div> </div><div class="et_pb_toggle et_pb_module et_pb_accordion_item et_pb_accordion_item_8 et_pb_toggle_close"> <h5 class="et_pb_toggle_title">News Feature | 20 March 2023</h5> <div class="et_pb_toggle_content clearfix"><h3><strong><span class="ui-provider azd aze azf azg azh azi azj azk azl azm azn azo azp azq azr azs azt azu azv azw azx azy azz baa bab bac bae baf bag bah bai baj bak bal bam" dir="ltr">The Fraunhofer Institute for Cellular Therapies and Immunology (IZI-BB) has published a press release highlighting how <span><span style="color: #009fe3;">switch</span>SENSE<sup>®</sup></span> is used at the institute to characterize binding interactions of SARS-CoV-2.</span></strong></h3> <p> <strong></strong></p> <p>The press release informs about the recent <a href="https://www.dynamic-biosensors.com/project/characterization-of-binding-interactions-of-sars-cov-2-spike-protein-and-dna-peptide-nanostructures/"><i>publication</i></a> of Kruse et al. in Nature Scientific Reports, in which researchers investigated the interaction between the SARS-CoV-2 spike protein and its receptor hACE2. To do so, they prepared trivalent DNA-peptide nanostructures to achieve a trimeric hACE2 peptide presentation. <span><span style="color: #009fe3;"><strong>switch</strong></span>SENSE<sup>®</sup></span> was used to examine the binding of full-length spike protein, subdomains and even whole virus particles. They show that small changes in the amino acid sequence of the spike protein can drastically influence the binding behavior. Furthermore, they demonstrate an increased affinity of the protein to the trivalent peptide construct as compared to single peptides. Finally, they detect different binding behaviors of pseudo virus models of the Alpha and Beta variants of SARS-CoV-2 compared to the inactivated wild type virus.</p> <p>This study shows the versatility of the <span><span style="color: #009fe3;"><strong>switch</strong></span>SENSE<sup>®</sup></span> technology, which enables the investigation of multivalent interactions and the utilization of a broad range of analytes from protein subdomains to whole virus particles.</p> <p>This work was part of the project <a href="https://www.izi-bb.fraunhofer.de/de/projekte/coronasense.html">“<i>CoronaSense</i>”</a> <a aria-label="Link https://www.izi-bb.fraunhofer.de/de/projekte/coronasense.html)" title="https://www.izi-bb.fraunhofer.de/de/projekte/coronasense.html)" href="https://www.izi-bb.fraunhofer.de/de/projekte/coronasense.html)" rel="noreferrer noopener" target="_blank" class="fui-Link ___1eya986 f3rmtva f1ewtqcl fyind8e f1k6fduh f1w7gpdv fk6fouc fjoy568 figsok6 f1hu3pq6 f11qmguv f19f4twv f1tyq0we f1g0x7ka fhxju0i f1qch9an f1cnd47f fqv5qza f1vmzxwi f1o700av f13mvf36 f1cmlufx f9n3di6 f1ids18y f1tx3yz7 f1deo86v f1eh06m1 f1iescvh fhgqx19 f1olyrje f1p93eir f1nev41a f1h8hb77 f1x7u7e9 f10aw75t fsle3fq f17ae5zn"></a> at the Fraunhofer Institute, which aims at using the <span><span style="color: #009fe3;"><strong>switch</strong></span>SENSE<sup>®</sup></span> technology in order to characterize binding interactions of SARS-CoV-2 Spike proteins with its receptors in more detail to aid the development of anti-viral drugs but also of diagnostic tests.</p></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </article> </div> <div class="et_pb_section et_pb_section_8 et_section_regular" > </div> <span class="et_pb_scroll_top et-pb-icon"></span> <footer id="main-footer"> <div class="container"> <div id="footer-widgets" class="clearfix"> <div class="footer-widget"><div id="text-5" class="fwidget et_pb_widget widget_text"><h4 class="title">Our Offices</h4> <div 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