[2102.11384] Knowledge-Based Three-Dimensional Dose Prediction for Tandem-And-Ovoid Brachytherapy

<?xml version="1.0" encoding="UTF-8"?> <!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd"> <html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en"> <head> <title>[2102.11384] Knowledge-Based Three-Dimensional Dose Prediction for Tandem-And-Ovoid Brachytherapy</title> <meta name="viewport" content="width=device-width, initial-scale=1"> <link rel="apple-touch-icon" sizes="180x180" href="/static/browse/0.3.4/images/icons/apple-touch-icon.png"> <link rel="icon" type="image/png" sizes="32x32" href="/static/browse/0.3.4/images/icons/favicon-32x32.png"> <link rel="icon" type="image/png" sizes="16x16" href="/static/browse/0.3.4/images/icons/favicon-16x16.png"> <link rel="manifest" href="/static/browse/0.3.4/images/icons/site.webmanifest"> <link rel="mask-icon" href="/static/browse/0.3.4/images/icons/safari-pinned-tab.svg" color="#5bbad5"> <meta name="msapplication-TileColor" content="#da532c"> <meta name="theme-color" content="#ffffff"> <link rel="stylesheet" type="text/css" media="screen" href="/static/browse/0.3.4/css/arXiv.css?v=20241206" /> <link rel="stylesheet" type="text/css" media="print" href="/static/browse/0.3.4/css/arXiv-print.css?v=20200611" /> <link rel="stylesheet" type="text/css" media="screen" href="/static/browse/0.3.4/css/browse_search.css" /> <script language="javascript" src="/static/browse/0.3.4/js/accordion.js" /></script> <link rel="stylesheet" type="text/css" media="screen" href="/static/browse/0.3.4/css/slider.css?v=20241211" /> <script src="//code.jquery.com/jquery-latest.min.js" type="text/javascript"></script> <script type="text/javascript" src="/static/browse/0.3.4/js/donate.js?v=121124"></script><link rel="canonical" href="https://arxiv.org/abs/2102.11384"/> <meta name="description" content="Abstract page for arXiv paper 2102.11384: Knowledge-Based Three-Dimensional Dose Prediction for Tandem-And-Ovoid Brachytherapy"><meta property="og:type" content="website" /> <meta property="og:site_name" content="arXiv.org" /> <meta property="og:title" content="Knowledge-Based Three-Dimensional Dose Prediction for Tandem-And-Ovoid Brachytherapy" /> <meta property="og:url" content="https://arxiv.org/abs/2102.11384v1" /> <meta property="og:image" content="/static/browse/0.3.4/images/arxiv-logo-fb.png" /> <meta property="og:image:secure_url" content="/static/browse/0.3.4/images/arxiv-logo-fb.png" /> <meta property="og:image:width" content="1200" /> <meta property="og:image:height" content="700" /> <meta property="og:image:alt" content="arXiv logo"/> <meta property="og:description" content="Purpose: To develop a knowledge-based voxel-wise dose prediction system using a convolution neural network for high-dose-rate brachytherapy cervical cancer treatments with a tandem-and-ovoid (T&O) applicator. Methods: A 3D U-NET was utilized to output dose predictions using organ-at-risk (OAR), high-risk clinical target volume (HRCTV), and possible source locations. A sample of previous T&O treatments comprising 397 cases (273 training:62 validation:62 test), HRCTV and OARs (bladder/rectum/sigmoid) was used. Structures and dose were interpolated to 1x1x2.5mm3 dose planes with two input channels (source positions, voxel identification) and one output channel for dose. We evaluated dose difference (螖D)(xyz)=D_(actual)(x,y,z)-D_(predicted)(x,y,z) and dice similarity coefficients in all cohorts across the clinically-relevant dose range (20-130% of prescription), mean and standard deviation. We also examined discrete DVH metrics used for T&O plan quality assessment: HRCTV D_90%(dose to hottest 90% volume) and OAR D_2cc, with 螖D_x=D_(x,actual)-D_(x,predicted). Pearson correlation coefficient, standard deviation, and mean quantified model performance on the clinical metrics. Results: Voxel-wise dose difference accuracy for 20-130% dose range for training(test) ranges for mean (螖D) and standard deviation for all voxels was [-0.3%+/-2.0% to +1.0%+/-12.0%] ([-0.1%+/-4% to +4.0%+/-26%]). Voxel-wise dice similarity coefficients for 20-130% dose ranged from [0.96, 0.91]([0.94, 0.87]). DVH metric prediction in the training (test) set were HRCTV(螖D_90)=-0.19+/-0.55 Gy (-0.09+/-0.67 Gy), bladder(螖D_2cc)=-0.06+/-0.54 Gy (-0.17+/-0.67 Gy), rectum(螖D)_2cc=-0.03+/-0.36 Gy (-0.04+/-0.46 Gy), and sigmoid(螖D_2cc)=-0.01+/-0.34 Gy (0.00+/-0.44 Gy). Conclusion: 3D knowledge-based dose predictions for T&O brachytherapy provide accurate voxel-level and DVH metric estimates."/> <meta name="twitter:site" content="@arxiv"/> <meta name="twitter:card" content="summary"/> <meta name="twitter:title" content="Knowledge-Based Three-Dimensional Dose Prediction for..."/> <meta name="twitter:description" content="Purpose: To develop a knowledge-based voxel-wise dose prediction system using a convolution neural network for high-dose-rate brachytherapy cervical cancer treatments with a tandem-and-ovoid (T&O)..."/> <meta name="twitter:image" content="https://static.arxiv.org/icons/twitter/arxiv-logo-twitter-square.png"/> <meta name="twitter:image:alt" content="arXiv logo"/> <link rel="stylesheet" media="screen" type="text/css" href="/static/browse/0.3.4/css/tooltip.css"/><link rel="stylesheet" media="screen" type="text/css" href="https://static.arxiv.org/js/bibex-dev/bibex.css?20200709"/> <script src="/static/browse/0.3.4/js/mathjaxToggle.min.js" type="text/javascript"></script> <script src="//code.jquery.com/jquery-latest.min.js" type="text/javascript"></script> <script src="//cdn.jsdelivr.net/npm/js-cookie@2/src/js.cookie.min.js" type="text/javascript"></script> <script src="//cdn.jsdelivr.net/npm/dompurify@2.3.5/dist/purify.min.js"></script> <script src="/static/browse/0.3.4/js/toggle-labs.js?20241022" type="text/javascript"></script> <script src="/static/browse/0.3.4/js/cite.js" type="text/javascript"></script><meta name="citation_title" content="Knowledge-Based Three-Dimensional Dose Prediction for Tandem-And-Ovoid Brachytherapy" /><meta name="citation_author" content="Cortes, Katherina G." /><meta name="citation_author" content="Simon, Aaron" /><meta name="citation_author" content="Kallis, Karoline" /><meta name="citation_author" content="Mayadev, Jyoti" /><meta name="citation_author" content="Meyers, Sandra" /><meta name="citation_author" content="Moore, Kevin L." /><meta name="citation_date" content="2021/02/22" /><meta name="citation_online_date" content="2021/02/22" /><meta name="citation_pdf_url" content="http://arxiv.org/pdf/2102.11384" /><meta name="citation_arxiv_id" content="2102.11384" /><meta name="citation_abstract" content="Purpose: To develop a knowledge-based voxel-wise dose prediction system using a convolution neural network for high-dose-rate brachytherapy cervical cancer treatments with a tandem-and-ovoid (T&O) applicator. Methods: A 3D U-NET was utilized to output dose predictions using organ-at-risk (OAR), high-risk clinical target volume (HRCTV), and possible source locations. A sample of previous T&O treatments comprising 397 cases (273 training:62 validation:62 test), HRCTV and OARs (bladder/rectum/sigmoid) was used. Structures and dose were interpolated to 1x1x2.5mm3 dose planes with two input channels (source positions, voxel identification) and one output channel for dose. We evaluated dose difference (\Delta D)(xyz)=D_(actual)(x,y,z)-D_(predicted)(x,y,z) and dice similarity coefficients in all cohorts across the clinically-relevant dose range (20-130% of prescription), mean and standard deviation. We also examined discrete DVH metrics used for T&O plan quality assessment: HRCTV D_90%(dose to hottest 90% volume) and OAR D_2cc, with \Delta D_x=D_(x,actual)-D_(x,predicted). Pearson correlation coefficient, standard deviation, and mean quantified model performance on the clinical metrics. Results: Voxel-wise dose difference accuracy for 20-130% dose range for training(test) ranges for mean (\Delta D) and standard deviation for all voxels was [-0.3%+/-2.0% to +1.0%+/-12.0%] ([-0.1%+/-4% to +4.0%+/-26%]). Voxel-wise dice similarity coefficients for 20-130% dose ranged from [0.96, 0.91]([0.94, 0.87]). DVH metric prediction in the training (test) set were HRCTV(\Delta D_90)=-0.19+/-0.55 Gy (-0.09+/-0.67 Gy), bladder(\Delta D_2cc)=-0.06+/-0.54 Gy (-0.17+/-0.67 Gy), rectum(\Delta D)_2cc=-0.03+/-0.36 Gy (-0.04+/-0.46 Gy), and sigmoid(\Delta D_2cc)=-0.01+/-0.34 Gy (0.00+/-0.44 Gy). Conclusion: 3D knowledge-based dose predictions for T&O brachytherapy provide accurate voxel-level and DVH metric estimates." /> </head> <body class="with-cu-identity"> <aside class="slider-wrapper bps-banner special-color"> <div class="columns"> <div class="copy-donation bps-banner"> <h2>Change to arXiv's privacy policy</h2> <p>The <a target="_blank" href="https://info.arxiv.org/help/policies/privacy_policy.html">arXiv Privacy Policy</a> has changed. 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href="https://arxiv.org/search/physics?searchtype=author&query=Cortes,+K+G" rel="nofollow">Katherina G. Cortes</a>, <a href="https://arxiv.org/search/physics?searchtype=author&query=Simon,+A" rel="nofollow">Aaron Simon</a>, <a href="https://arxiv.org/search/physics?searchtype=author&query=Kallis,+K" rel="nofollow">Karoline Kallis</a>, <a href="https://arxiv.org/search/physics?searchtype=author&query=Mayadev,+J" rel="nofollow">Jyoti Mayadev</a>, <a href="https://arxiv.org/search/physics?searchtype=author&query=Meyers,+S" rel="nofollow">Sandra Meyers</a>, <a href="https://arxiv.org/search/physics?searchtype=author&query=Moore,+K+L" rel="nofollow">Kevin L. Moore</a></div> <div id="download-button-info" hidden>View a PDF of the paper titled Knowledge-Based Three-Dimensional Dose Prediction for Tandem-And-Ovoid Brachytherapy, by Katherina G. Cortes and 5 other authors</div> <a class="mobile-submission-download" href="/pdf/2102.11384">View PDF</a> <blockquote class="abstract mathjax"> <span class="descriptor">Abstract:</span>Purpose: To develop a knowledge-based voxel-wise dose prediction system using a convolution neural network for high-dose-rate brachytherapy cervical cancer treatments with a tandem-and-ovoid (T&O) applicator. Methods: A 3D U-NET was utilized to output dose predictions using organ-at-risk (OAR), high-risk clinical target volume (HRCTV), and possible source locations. A sample of previous T&O treatments comprising 397 cases (273 training:62 validation:62 test), HRCTV and OARs (bladder/rectum/sigmoid) was used. Structures and dose were interpolated to 1x1x2.5mm3 dose planes with two input channels (source positions, voxel identification) and one output channel for dose. We evaluated dose difference (\Delta D)(xyz)=D_(actual)(x,y,z)-D_(predicted)(x,y,z) and dice similarity coefficients in all cohorts across the clinically-relevant dose range (20-130% of prescription), mean and standard deviation. We also examined discrete DVH metrics used for T&O plan quality assessment: HRCTV D_90%(dose to hottest 90% volume) and OAR D_2cc, with \Delta D_x=D_(x,actual)-D_(x,predicted). Pearson correlation coefficient, standard deviation, and mean quantified model performance on the clinical metrics. Results: Voxel-wise dose difference accuracy for 20-130% dose range for training(test) ranges for mean (\Delta D) and standard deviation for all voxels was [-0.3%+/-2.0% to +1.0%+/-12.0%] ([-0.1%+/-4% to +4.0%+/-26%]). Voxel-wise dice similarity coefficients for 20-130% dose ranged from [0.96, 0.91]([0.94, 0.87]). DVH metric prediction in the training (test) set were HRCTV(\Delta D_90)=-0.19+/-0.55 Gy (-0.09+/-0.67 Gy), bladder(\Delta D_2cc)=-0.06+/-0.54 Gy (-0.17+/-0.67 Gy), rectum(\Delta D)_2cc=-0.03+/-0.36 Gy (-0.04+/-0.46 Gy), and sigmoid(\Delta D_2cc)=-0.01+/-0.34 Gy (0.00+/-0.44 Gy). Conclusion: 3D knowledge-based dose predictions for T&O brachytherapy provide accurate voxel-level and DVH metric estimates. </blockquote>  <div class="metatable"> <table summary="Additional metadata"><tr> <td class="tablecell label">Subjects:</td> <td class="tablecell subjects"> <span class="primary-subject">Medical Physics (physics.med-ph)</span></td> </tr><tr> <td class="tablecell label">Cite as:</td> <td class="tablecell arxivid"><span class="arxivid"><a href="https://arxiv.org/abs/2102.11384">arXiv:2102.11384</a> [physics.med-ph]</span></td> </tr> <tr> <td class="tablecell label"> </td> <td class="tablecell arxividv">(or <span class="arxivid"> <a href="https://arxiv.org/abs/2102.11384v1">arXiv:2102.11384v1</a> [physics.med-ph]</span> for this version) </td> </tr> <tr> <td class="tablecell label"> </td> <td class="tablecell arxivdoi"> <a href="https://doi.org/10.48550/arXiv.2102.11384" id="arxiv-doi-link">https://doi.org/10.48550/arXiv.2102.11384</a><div class="button-and-tooltip"> <button class="more-info" aria-describedby="more-info-desc-1"> <svg height="15" role="presentation" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256 8C119.043 8 8 119.083 8 256c0 136.997 111.043 248 248 248s248-111.003 248-248C504 119.083 392.957 8 256 8zm0 110c23.196 0 42 18.804 42 42s-18.804 42-42 42-42-18.804-42-42 18.804-42 42-42zm56 254c0 6.627-5.373 12-12 12h-88c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h12v-64h-12c-6.627 0-12-5.373-12-12v-24c0-6.627 5.373-12 12-12h64c6.627 0 12 5.373 12 12v100h12c6.627 0 12 5.373 12 12v24z" class=""></path></svg> <span class="visually-hidden">Focus to learn more</span> </button>  <div role="tooltip" id="more-info-desc-1"> <span class="left-corner"></span> arXiv-issued DOI via DataCite</div> </div> </td> </tr></table> </div> </div> </div> <div class="submission-history"> <h2>Submission history</h2> From: Katherina Cortes [<a href="/show-email/1c22e6ea/2102.11384" rel="nofollow">view email</a>] <br/> <strong>[v1]</strong> Mon, 22 Feb 2021 22:12:52 UTC (1,026 KB)<br/> </div> </div>  <div class="extra-services"> <div class="full-text"> <a name="other"></a> <span class="descriptor">Full-text links:</span> <h2>Access Paper:</h2> <ul> <div id="download-button-info" hidden> View a PDF of the paper titled Knowledge-Based Three-Dimensional Dose Prediction for Tandem-And-Ovoid Brachytherapy, by Katherina G. 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[2102.11384] Knowledge-Based Three-Dimensional Dose Prediction for Tandem-And-Ovoid Brachytherapy