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Wakefield’s article linking MMR vaccine and autism was fraudulent | The BMJ
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML+RDFa 1.0//EN" "http://www.w3.org/MarkUp/DTD/xhtml-rdfa-1.dtd"> <!--[if lt IE 7]> <html class="no-mqs lt-ie9 lt-ie8 lt-ie7" lang="en" xml:lang="en" dir="ltr" > <![endif]--> <!--[if IE 7]> <html class="no-mqs lt-ie9 lt-ie8" lang="en" xml:lang="en" dir="ltr" > <![endif]--> <!--[if IE 8]> <html class="no-mqs lt-ie9" lang="en" xml:lang="en" dir="ltr" > <![endif]--> <!--[if gt IE 8]><!--> <html xml:lang="en" lang="en" dir="ltr" > <!--<![endif]--> <!--[if IE 9]> <html class="no-mqs" lang="en" xml:lang="en" dir="ltr" > <![endif]--> <!-- <html lang="" dir=""> --> <head profile="http://www.w3.org/1999/xhtml/vocab"> <meta charset="utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link rel=”apple-touch-icon-precomposed” href=”/sites/default/themes/bmj/the_bmj/img/icon.png”/> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <!--[if IE]><![endif]--> <link rel="dns-prefetch" href="//static.polldaddy.com" /> <link rel="dns-prefetch" href="//ajax.googleapis.com" /> <link rel="dns-prefetch" href="//crossmark-cdn.crossref.org" /> <link rel="dns-prefetch" href="//d1bxh8uas1mnw7.cloudfront.net" /> <link rel="dns-prefetch" href="//www.google.com" /> <link rel="dns-prefetch" href="//scholar.google.com" /> <meta http-equiv="Content-Type" content="text/html; charset=utf-8" /> <link rel="shortcut icon" href="https://www.bmj.com/sites/default/themes/bmj/the_bmj/favicon.ico" type="image/vnd.microsoft.icon" /> <!--[if (gte IE 6)&(lte IE 9)]><script src="/sites/default/themes/bmj/the_bmj/js/respond.min.js" /> </script><![endif]--><link href="//netdna.bootstrapcdn.com/font-awesome/4.0.3/css/font-awesome.css" rel="stylesheet" media="all" type="text/css" /> <link rel="alternate" type="text/plain" title="Full Text (Plain)" href="/content/342/bmj.c7452.full.txt" /> <meta name="type" content="article" /> <meta name="category" content="editorial" /> <meta name="HW.identifier" content="/bmj/342/bmj.c7452.atom" /> <meta name="HW.pisa" content="bmj;342/jan05_1/c7452" /> <meta name="DC.Format" content="text/html" /> <meta name="DC.Language" content="en" /> <meta name="DC.Title" content="Wakefield’s article linking MMR vaccine and autism was fraudulent" /> <meta name="DC.Identifier" content="10.1136/bmj.c7452" /> <meta name="DC.Date" content="2011-01-06" /> <meta name="DC.Publisher" content="British Medical Journal Publishing Group" /> <meta name="DC.Rights" content="© BMJ Publishing Group Ltd 2011" /> <meta name="DC.AccessRights" content="restricted" /> <meta name="DC.Relation" content="10.1136/bmj.c5347" /> <meta name="DC.Relation" content="10.1136/bmj.d22" /> <meta name="DC.Relation" content="10.1136/bmj.325.7361.419" /> <meta name="DC.Relation" content="10.1136/bmj.329.7456.41" /> <meta name="DC.Relation" content="10.1136/bmj.324.7334.393" /> <meta name="DC.Relation" content="10.1136/bmj.d1678" /> <meta name="DC.Relation" content="10.1136/bmj.d2010" /> <meta name="DC.Relation" content="10.1136/bmj.d5703" /> <meta name="DC.Relation" content="10.1136/bmj.e5328" /> <meta name="DC.Relation" content="10.1136/bmj.e6220" /> <meta name="DC.Relation" content="10.1136/bmj.d460" /> <meta name="DC.Relation" content="10.1136/bmj.d1678" /> <meta name="DC.Relation" content="10.1136/sbmj.d355" /> <meta name="DC.Relation" content="10.1136/sbmj.d1166" /> <meta name="DC.Relation" content="10.1136/bmj.l5477" /> <meta name="DC.Description" content="Clear evidence of falsification of data should now close the door on this damaging vaccine scare “Science is at once the most questioning and . . . sceptical of activities and also the most trusting,” said Arnold Relman, former editor of the New England Journal of Medicine , in 1989. “It is intensely sceptical about the possibility of error, but totally trusting about the possibility of fraud.”1 Never has this been truer than of the 1998 Lancet paper that implied a link between the measles, mumps, and rubella (MMR) vaccine and a “new syndrome” of autism and bowel disease.⇓ Authored by Andrew Wakefield and 12 others, the paper’s scientific limitations were clear when it appeared in 1998.2 3 As the ensuing vaccine scare took off, critics quickly pointed out that the paper was a small case series with no controls, linked three common conditions, and relied on parental recall and beliefs.4 Over the following decade, epidemiological studies consistently found no evidence of a link between the MMR vaccine and autism.5 6 7 8 By the time the paper was finally retracted 12 years later,9 after forensic dissection at the General Medical Council’s (GMC) longest ever fitness to practise hearing,10 few people could deny that it was fatally flawed both scientifically and ethically. But it has taken the diligent scepticism of one man, standing outside medicine and science, to show that the paper was in fact an elaborate fraud. In a series of articles starting this week, and seven years after first looking into the MMR scare, journalist Brian Deer now shows the extent of Wakefield’s fraud and how it was perpetrated (doi:10.1136/bmj.c5347). Drawing on interviews, documents, and data made public at the GMC hearings, Deer shows how Wakefield altered …" /> <meta name="DC.Contributor" content="Fiona Godlee" /> <meta name="DC.Contributor" content="Jane Smith" /> <meta name="DC.Contributor" content="Harvey Marcovitch" /> <meta name="article:published_time" content="2011-01-06" /> <meta name="article:section" content="Editorial" /> <meta name="citation_title" content="Wakefield’s article linking MMR vaccine and autism was fraudulent" /> <meta name="citation_abstract" lang="en" scheme="teaser" content="<p>Clear evidence of falsification of data should now close the door on this damaging vaccine scare</p>" /> <meta name="citation_journal_title" content="BMJ" /> <meta name="citation_publisher" content="British Medical Journal Publishing Group" /> <meta name="citation_publication_date" content="2011/01/06" /> <meta name="citation_mjid" content="bmj;342/jan05_1/c7452" /> <meta name="citation_id" content="342/jan05_1/c7452" /> <meta name="citation_public_url" content="https://www.bmj.com/content/342/bmj.c7452" /> <meta name="citation_abstract_html_url" content="https://www.bmj.com/content/342/bmj.c7452.abstract" /> <meta name="citation_full_html_url" content="https://www.bmj.com/content/342/bmj.c7452.full" /> <meta name="citation_issn" content="0959-8138" /> <meta name="citation_issn" content="1468-5833" /> <meta name="citation_journal_abbrev" content="BMJ" /> <meta name="citation_doi" content="10.1136/bmj.c7452" /> <meta name="citation_pmid" content="21209060" /> <meta name="citation_volume" content="342" /> <meta name="citation_article_type" content="Editorial" /> <meta name="citation_section" content="Editorial" /> <meta name="citation_author" content="Fiona Godlee" /> <meta name="citation_author" content="Jane Smith" /> <meta name="citation_author" content="Harvey Marcovitch" /> <meta name="twitter:title" content="Wakefield’s article linking MMR vaccine and autism was fraudulent" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:description" content="Clear evidence of falsification of data should now close the door on this damaging vaccine scare “Science is at once the most questioning and . . . sceptical of activities and also the most trusting,” said Arnold Relman, former editor of the New England Journal of Medicine , in 1989. “It is intensely sceptical about the possibility of error, but totally trusting about the possibility of fraud.”1 Never has this been truer than of the 1998 Lancet paper that implied a link between the measles, mumps, and rubella (MMR) vaccine and a “new syndrome” of autism and bowel disease.⇓ Authored by Andrew Wakefield and 12 others, the paper’s scientific limitations were clear when it appeared in 1998.2 3 As the ensuing vaccine scare took off, critics quickly pointed out that the paper was a small case series with no controls, linked three common conditions, and relied on parental recall and beliefs.4 Over the following decade, epidemiological studies consistently found no evidence of a link between the MMR vaccine and autism.5 6 7 8 By the time the paper was finally retracted 12 years later,9 after forensic dissection at the General Medical Council’s (GMC) longest ever fitness to practise hearing,10 few people could deny that it was fatally flawed both scientifically and ethically. But it has taken the diligent scepticism of one man, standing outside medicine and science, to show that the paper was in fact an elaborate fraud. In a series of articles starting this week, and seven years after first looking into the MMR scare, journalist Brian Deer now shows the extent of Wakefield’s fraud and how it was perpetrated (doi:10.1136/bmj.c5347). Drawing on interviews, documents, and data made public at the GMC hearings, Deer shows how Wakefield altered …" /> <meta name="og-title" property="og:title" content="Wakefield’s article linking MMR vaccine and autism was fraudulent" /> <meta name="og-url" property="og:url" content="https://www.bmj.com/content/342/bmj.c7452" /> <meta name="og-site-name" property="og:site_name" content="The BMJ" /> <meta name="og-description" property="og:description" content="Clear evidence of falsification of data should now close the door on this damaging vaccine scare “Science is at once the most questioning and . . . sceptical of activities and also the most trusting,” said Arnold Relman, former editor of the New England Journal of Medicine , in 1989. “It is intensely sceptical about the possibility of error, but totally trusting about the possibility of fraud.”1 Never has this been truer than of the 1998 Lancet paper that implied a link between the measles, mumps, and rubella (MMR) vaccine and a “new syndrome” of autism and bowel disease.⇓ Authored by Andrew Wakefield and 12 others, the paper’s scientific limitations were clear when it appeared in 1998.2 3 As the ensuing vaccine scare took off, critics quickly pointed out that the paper was a small case series with no controls, linked three common conditions, and relied on parental recall and beliefs.4 Over the following decade, epidemiological studies consistently found no evidence of a link between the MMR vaccine and autism.5 6 7 8 By the time the paper was finally retracted 12 years later,9 after forensic dissection at the General Medical Council’s (GMC) longest ever fitness to practise hearing,10 few people could deny that it was fatally flawed both scientifically and ethically. But it has taken the diligent scepticism of one man, standing outside medicine and science, to show that the paper was in fact an elaborate fraud. In a series of articles starting this week, and seven years after first looking into the MMR scare, journalist Brian Deer now shows the extent of Wakefield’s fraud and how it was perpetrated (doi:10.1136/bmj.c5347). Drawing on interviews, documents, and data made public at the GMC hearings, Deer shows how Wakefield altered …" /> <meta name="og-type" property="og:type" content="article" /> <meta name="og:image" property="og:image" content="https://www.bmj.com/sites/default/files/highwire/bmj/387/8450.cover-source.jpg"/> <meta name="twitter:card" content="summary_large_image"><meta name="twitter:image" property="twitter:image" content="https://www.bmj.com/content/bmj/342/bmj.c7452/F1.large.jpg"><meta name="twitter:title" content="Wakefield’s article linking MMR vaccine and autism was fraudulent" /><link rel="alternate" type="application/vnd.ms-powerpoint" title="Powerpoint" href="/content/342/bmj.c7452.ppt" /> <script>window.dataLayer = window.dataLayer || [];window.dataLayer.push({"page":{"hwTitle":"Wakefield\u2019s article linking MMR vaccine and autism was fraudulent","hwUrl":"https://www.bmj.com/content/342/bmj.c7452","hwPath":"/content/342/bmj.c7452","hwType":"journal 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class="left-content col-xs-12 col-sm-8 col-md-8 col-lg-8"> <article> <div class="panel-pane pane-highwire-article-citation" > <div class="pane-content"> <div class="highwire-article-citation highwire-citation-type-highwire-article node197724" data-node-nid="197724" id="node-197724--2826080100" data-pisa="bmj;342/jan05_1/c7452" data-pisa-master="bmj;bmj.c7452" data-apath="/bmj/342/bmj.c7452.atom"><cite class='highwire-cite highwire-citation-bmj-article-top'> <span class='highwire-cite-article-type'>Editorials</span> <h1 class="highwire-cite-title" id="page-title">Wakefield’s article linking MMR vaccine and autism was fraudulent</h1> <span class='highwire-cite-journal'>BMJ</span> <span class='highwire-cite-published-year'>2011</span>; <span class='highwire-cite-volume-issue'>342</span> <span class='highwire-cite-doi'> doi: <a href="https://doi.org/10.1136/bmj.c7452">https://doi.org/10.1136/bmj.c7452</a></span> <span class='highwire-cite-date'>(Published 06 January 2011)</span> <span class='highwire-cite-article-as'> Cite this as: <span class="italic">BMJ</span> 2011;342:c7452 </span> </cite> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-panel-tabs pane-panels-ajax-tab-tabs" > <div class="pane-content"> <ul class="tabs inline panels-ajax-tab"><li class="first"><a title="Article Tab - Article" href="/content/342/bmj.c7452" class="panels-ajax-tab-tab" data-panel-name="jnl_bmj_tab_art" data-target-id="highwire_article_tabs" data-entity-context="node:197724" data-trigger="" data-url-enabled="1"><span>Article</span></a><a title="Article Tab - Article" href="/panels_ajax_tab/jnl_bmj_tab_art/node:197724/1" rel="nofollow" style="display:none" class="js-crawler-link"></a></li> <li><a title="Article Tab - Related Articles" href="/content/342/bmj.c7452/related" class="panels-ajax-tab-tab" data-panel-name="jnl_bmj_tab_related_art" data-target-id="highwire_article_tabs" data-entity-context="node:197724" data-trigger="related" 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highwire-correction-type-correction"><h3 class="highwire-corrections-title">This article has a correction. Please see:</h3><ul class="highwire-corrections-list"><li class="relation-1654002 first last"><a href="/content/342/bmj.d1678">Errata - March 15, 2011</a></li> </ul></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-markup" > <div class="pane-content"> <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" data-highwire-cite-ref-tooltip-instance="highwire_reflinks_tooltip" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="article fulltext-view"><span class="highwire-journal-article-marker-start"></span><div class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">Fiona Godlee</span><span class="contrib-role">, editor in chief</span>, </li><li class="contributor" id="contrib-2"><span class="name">Jane Smith</span><span class="contrib-role">, deputy editor</span>, </li><li class="last" id="contrib-3"><span class="name">Harvey Marcovitch</span><span class="contrib-role">, associate editor</span></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>1</sup>BMJ, London, UK</address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1">Correspondence to: F Godlee <span class="em-link"><span class="em-addr">fgodlee{at}bmj.com</span></span></li></ol></div><div class="teaser"><p id="p-1">Clear evidence of falsification of data should now close the door on this damaging vaccine scare</p></div><p id="p-2">“Science is at once the most questioning and . . . sceptical of activities and also the most trusting,” said Arnold Relman, former editor of the <em>New England Journal of Medicine</em>, in 1989. “It is intensely sceptical about the possibility of error, but totally trusting about the possibility of fraud.”<a id="xref-ref-1-1" class="xref-bibr" href="#ref-1">1</a> Never has this been truer than of the 1998 <em>Lancet</em> paper that implied a link between the measles, mumps, and rubella (MMR) vaccine and a “new syndrome” of autism and bowel disease.<a id="xref-fig-1-1" class="xref-down-link" href="#F1"><span>⇓</span></a></p><div id="F1" class="fig pos-float type-theme odd"><div class="fig-inline"><div class="highwire-figure"><div class="fig-inline-img-wrapper"><div class="fig-inline-img"><a href="https://www.bmj.com/content/bmj/342/bmj.c7452/F1.large.jpg?width=800&height=600" title="" class="colorbox fragment-images colorbox-load" rel="gallery-fragment-images" data-figure-caption="<div class="highwire-markup"></div>"><img class="fragment-image" src="https://www.bmj.com/content/bmj/342/bmj.c7452/F1.medium.gif" alt="Figure1"/></a></div></div><ul class="highwire-figure-links list-inline"><li class="download-fig first"><a href="https://www.bmj.com/content/bmj/342/bmj.c7452/F1.large.jpg?download=true" class="highwire-figure-link highwire-figure-link-download" title="Download Figure1">Download figure</a></li> <li class="new-tab"><a href="https://www.bmj.com/content/bmj/342/bmj.c7452/F1.large.jpg" class="highwire-figure-link highwire-figure-link-newtab" target="_blank">Open in new tab</a></li> <li class="download-ppt last"><a href="/highwire/powerpoint/592642" class="highwire-figure-link highwire-figure-link-ppt">Download powerpoint</a></li> </ul></div></div></div><p id="p-3">Authored by Andrew Wakefield and 12 others, the paper’s scientific limitations were clear when it appeared in 1998.<a id="xref-ref-2-1" class="xref-bibr" href="#ref-2">2</a> <a id="xref-ref-3-1" class="xref-bibr" href="#ref-3">3</a> As the ensuing vaccine scare took off, critics quickly pointed out that the paper was a small case series with no controls, linked three common conditions, and relied on parental recall and beliefs.<a id="xref-ref-4-1" class="xref-bibr" href="#ref-4">4</a> Over the following decade, epidemiological studies consistently found no evidence of a link between the MMR vaccine and autism.<a id="xref-ref-5-1" class="xref-bibr" href="#ref-5">5</a> <a id="xref-ref-6-1" class="xref-bibr" href="#ref-6">6</a> <a id="xref-ref-7-1" class="xref-bibr" href="#ref-7">7</a> <a id="xref-ref-8-1" class="xref-bibr" href="#ref-8">8</a> By the time the paper was finally retracted 12 years later,<a id="xref-ref-9-1" class="xref-bibr" href="#ref-9">9</a> after forensic dissection at the General Medical Council’s (GMC) longest ever fitness to practise hearing,<a id="xref-ref-10-1" class="xref-bibr" href="#ref-10">10</a> few people could deny that it was fatally flawed both scientifically and ethically. But it has taken the diligent scepticism of one man, standing outside medicine and science, to show that the paper was in fact an elaborate fraud.</p><p id="p-4">In a series of articles starting this week, and seven years after first looking into the MMR scare, journalist Brian Deer now shows the extent of Wakefield’s fraud and how it was perpetrated (doi:<a href="/lookup/doi/10.1136/bmj.c5347">10.1136/bmj.c5347</a>). Drawing on interviews, documents, and data made public at the GMC hearings, Deer shows how Wakefield altered numerous facts about the patients’ medical histories in order to support his claim to have identified a new syndrome; how his institution, the Royal Free Hospital and Medical School in London, supported him as he sought to exploit the ensuing MMR scare for financial gain; and how key players failed to investigate thoroughly in the public interest when Deer first raised his concerns.<a id="xref-ref-11-1" class="xref-bibr" href="#ref-11">11</a></p><p id="p-5">Deer published his first investigation into Wakefield’s paper in 2004.<a id="xref-ref-12-1" class="xref-bibr" href="#ref-12">12</a> This uncovered the possibility of research fraud, unethical treatment of children, and Wakefield’s conflict of interest through his involvement with a lawsuit against manufacturers of the MMR vaccine. Building on these findings, the GMC launched its own proceedings that focused on whether the research was ethical. But while the disciplinary panel was examining the children’s medical records in public, Deer compared them with what was published in the <em>Lancet</em>. His focus was now on whether the research was true.</p><p id="p-6">The Office of Research Integrity in the United States defines fraud as fabrication, falsification, or plagiarism.<a id="xref-ref-13-1" class="xref-bibr" href="#ref-13">13</a> Deer unearthed clear evidence of falsification. He found that not one of the 12 cases reported in the 1998 <em>Lancet </em>paper was free of misrepresentation or undisclosed alteration, and that in no single case could the medical records be fully reconciled with the descriptions, diagnoses, or histories published in the journal.</p><p id="p-7">Who perpetrated this fraud? There is no doubt that it was Wakefield. Is it possible that he was wrong, but not dishonest: that he was so incompetent that he was unable to fairly describe the project, or to report even one of the 12 children’s cases accurately? No. A great deal of thought and effort must have gone into drafting the paper to achieve the results he wanted: the discrepancies all led in one direction; misreporting was gross. Moreover, although the scale of the GMC’s 217 day hearing precluded additional charges focused directly on the fraud, the panel found him guilty of dishonesty concerning the study’s admissions criteria, its funding by the Legal Aid Board, and his statements about it afterwards.<a id="xref-ref-14-1" class="xref-bibr" href="#ref-14">14</a></p><p id="p-8">Furthermore, Wakefield has been given ample opportunity either to replicate the paper’s findings, or to say he was mistaken. He has declined to do either. He refused to join 10 of his coauthors in retracting the paper’s interpretation in 2004,<a id="xref-ref-15-1" class="xref-bibr" href="#ref-15">15</a> and has repeatedly denied doing anything wrong at all. Instead, although now disgraced and stripped of his clinical and academic credentials, he continues to push his views.<a id="xref-ref-16-1" class="xref-bibr" href="#ref-16">16</a></p><p id="p-9">Meanwhile the damage to public health continues, fuelled by unbalanced media reporting and an ineffective response from government, researchers, journals, and the medical profession.<a id="xref-ref-17-1" class="xref-bibr" href="#ref-17">17</a> <a id="xref-ref-18-1" class="xref-bibr" href="#ref-18">18</a> Although vaccination rates in the United Kingdom have recovered slightly from their 80% low in 2003-4,<a id="xref-ref-19-1" class="xref-bibr" href="#ref-19">19</a> they are still below the 95% level recommended by the World Health Organization to ensure herd immunity. In 2008, for the first time in 14 years, measles was declared endemic in England and Wales.<a id="xref-ref-20-1" class="xref-bibr" href="#ref-20">20</a> Hundreds of thousands of children in the UK are currently unprotected as a result of the scare, and the battle to restore parents’ trust in the vaccine is ongoing.</p><p id="p-10">Any effect of the scare on the incidence of mumps remains in question. In epidemics in the UK, the US, and the Netherlands, peak prevalence was in 18-24 year olds, of whom 70-88% had been immunised with at least one dose of the MMR vaccine.<a id="xref-ref-21-1" class="xref-bibr" href="#ref-21">21</a> <a id="xref-ref-22-1" class="xref-bibr" href="#ref-22">22</a> Any consequence of a fall in uptake after 1998 may not become apparent until the cohorts of children affected reach adolescence. One clue comes from an outbreak in a school in Essen, Germany, attended by children whose parents were opposed to vaccinations. Of the 71 children infected with mumps, 68 had not been immunised.<a id="xref-ref-23-1" class="xref-bibr" href="#ref-23">23</a></p><p id="p-11">But perhaps as important as the scare’s effect on infectious disease is the energy, emotion, and money that have been diverted away from efforts to understand the real causes of autism and how to help children and families who live with it.<a id="xref-ref-24-1" class="xref-bibr" href="#ref-24">24</a></p><p id="p-12">There are hard lessons for many in this highly damaging saga. Firstly, for the coauthors. The GMC panel was clear that it was Wakefield alone who wrote the final version of the paper. His coauthors seem to have been unaware of what he was doing under the cover of their names and reputations. As the GMC panel heard, they did not even know which child was which in the paper’s patient anonymised text and tables. However, this does not absolve them. Although only two (John Walker-Smith and Simon Murch) were charged by the GMC, and only one, the paper’s senior author Walker-Smith, was found guilty of misconduct, they all failed in their duties as authors. The satisfaction of adding to one’s CV must never detract from the responsibility to ensure that one has been neither party to nor duped by a fraud. This means that coauthors will have to check the source data of studies more thoroughly than many do at present—or alternatively describe in a contributor’s statement precisely which bits of the source data they take responsibility for.</p><p id="p-13">Secondly, research ethics committees should not only scrutinise proposals but have systems to check that what is done is what was permitted (with an audit trail for any changes) and work to a governance procedure that can impose sanctions where an eventual publication proves this was not the case. Finally, there are lessons for the Royal Free Hospital, the <em>Lancet</em>, and the wider scientific community. These will be considered in forthcoming articles.</p><p id="p-14">What of Wakefield’s other publications? In light of this new information their veracity must be questioned. Past experience tells us that research misconduct is rarely isolated behaviour.<a id="xref-ref-25-1" class="xref-bibr" href="#ref-25">25</a> Over the years, the <em>BMJ</em> and its sister journals <em>Gut</em> and <em>Archives of Disease in Childhood</em> have published a number of articles, including letters and abstracts, by Wakefield and colleagues. We have written to the vice provost of UCL, John Tooke, who now has responsibility for Wakefield’s former institution, to ask for an investigation into all of his work to decide whether any more papers should be retracted.</p><p id="p-15">The <em>Lancet</em> paper has of course been retracted, but for far narrower misconduct than is now apparent. The retraction statement cites the GMC’s findings that the patients were not consecutively referred and the study did not have ethical approval, leaving the door open for those who want to continue to believe that the science, flawed though it always was, still stands. We hope that declaring the paper a fraud will close that door for good.</p><div class="section notes" id="notes-2"><h2>Notes</h2><p id="p-18"><strong>Cite this as:</strong> <em>BMJ</em> 2011;342:c7452</p></div><div class="section fn-group" id="fn-group-1"><h2>Footnotes</h2><ul><li class="fn" id="related-article-1"><a href="/lookup/doi/10.1136/bmj.c5347">Feature, doi:10.1136/bmj.c5347</a></li><li class="fn-conflict" id="fn-1"><p id="p-16">Competing interests: All authors have completed the Unified Competing Interest form at <a href="http://www.icmje.org/coi_disclosure.pdf">www.icmje.org/coi_disclosure.pdf</a> (available on request from the corresponding author) and declare: no support from any organisation for the submitted work; no financial relationships with any organisations that might have an interest in the submitted work in the previous three years. HM chairs GMC fitness to practise panels. He had no association with the Wakefield hearings and the views expressed in this article are his own and do not represent those of the GMC.</p></li><li class="fn" id="fn-2"><p id="p-17">Provenance and peer review: Commissioned; not externally peer reviewed.</p></li></ul></div><div class="section ref-list" id="ref-list-1"><h2>References</h2><ol class="cit-list"><li><a class="rev-xref-ref" href="#xref-ref-1-1" title="View reference 1 in text" id="ref-1">↵</a><div class="cit ref-cit ref-journal" id="cit-342.jan05_1.c7452.1"><div class="cit-metadata"><cite>Schechter AN, Wyngaarden JB, Edsall JT, Maddox J, Relman AS, Angell M, et al. 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data-pisa="bmj;342/jan05_1/c7452" data-pisa-master="bmj;bmj.c7452" data-apath="/bmj/342/bmj.c7452.atom"><div id="jnl_bmj_custom_authors" style="display: none;"><span data-delta="0"><span class="nlm-given-names">Fiona</span> <span class="nlm-surname">Godlee</span></span>, <span data-delta="1"><span class="nlm-given-names">Jane</span> <span class="nlm-surname">Smith</span></span>, <span data-delta="2"><span class="nlm-given-names">Harvey</span> <span class="nlm-surname">Marcovitch</span></span></div> <div class="highwire-cite highwire-cite-highwire-article highwire-citation-bmj-article-citation-export clearfix" > <span class="highwire-cite-authors" ><!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN" "http://www.w3.org/TR/REC-html40/loose.dtd"> <html><body><span data-delta="0"><span class="nlm-surname">Godlee</span> <span class="nlm-given-names">F</span></span>, <span data-delta="1"><span class="nlm-surname">Smith</span> <span class="nlm-given-names">J</span></span>, <span data-delta="2"><span class="nlm-surname">Marcovitch</span> <span class="nlm-given-names">H</span></span>. </body></html> </span> <span class="highwire-cite-title article-title">Wakefield’s article linking MMR vaccine and autism was fraudulent</span> <span class="highwire-cite-metadata" ><span class="highwire-cite-metadata-journal highwire-cite-metadata">BMJ </span><span class="highwire-cite-metadata-date highwire-cite-metadata">2011; </span><span class="highwire-cite-metadata-volume highwire-cite-metadata">342 </span><span class="highwire-cite-metadata-volume highwire-cite-metadata">:c7452 </span></span> <span class="article-doi" >doi:10.1136/bmj.c7452</span> </div> </div> </div> <div class="highwire-citation-formats"> <div class="highwire-citation-formats-links"> <span class="Z3988" 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