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<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "DTD/xhtml1-transitional.dtd"> <html xmlns="http://www.w3.org/1999/xhtml"> <head> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8"/> <meta http-equiv="expires" content="43200"/>   <title>mediaTUM - Medien- und Publikationsserver</title> <meta name="generator" content="mediatum - a multimedia content repository"/> <link rel="icon" type="image/vnd.microsoft.icon" href="/favicon.ico"/> <link rel="apple-touch-icon" sizes="57x57" href="/apple-touch-icon-57x57.png"/> <link rel="apple-touch-icon" sizes="60x60" href="/apple-touch-icon-60x60.png"/> <link rel="apple-touch-icon" sizes="72x72" href="/apple-touch-icon-72x72.png"/> <link rel="apple-touch-icon" sizes="76x76" href="/apple-touch-icon-76x76.png"/> <link rel="apple-touch-icon" sizes="114x114" href="/apple-touch-icon-114x114.png"/> <link rel="apple-touch-icon" sizes="120x120" href="/apple-touch-icon-120x120.png"/> <link rel="apple-touch-icon" sizes="144x144" href="/apple-touch-icon-144x144.png"/> <link rel="apple-touch-icon" sizes="152x152" href="/apple-touch-icon-152x152.png"/> <link rel="apple-touch-icon" sizes="180x180" href="/apple-touch-icon-180x180.png"/> <link rel="icon" type="image/png" href="/favicon-32x32.png" sizes="32x32"/> <link rel="icon" type="image/png" href="/favicon-194x194.png" sizes="194x194"/> <link rel="icon" type="image/png" href="/favicon-96x96.png" sizes="96x96"/> <link rel="icon" type="image/png" href="/android-chrome-192x192.png" sizes="192x192"/> <link rel="icon" type="image/png" href="/favicon-16x16.png" sizes="16x16"/> <meta name="msapplication-TileColor" content="#ffffff"/> <meta name="msapplication-TileImage" content="/mstile-144x144.png"/> <meta name="theme-color" content="#ffffff"/> <link rel="stylesheet" href="/static/css/mediatum.css"/> <script src="/static/js/mediatum.js"></script> <script src="/static/js/jquery-1.12.4.js"></script> <script type="text/javascript" language="javascript">function change_size(){ var searchform = $('#search-form').height(); var cheight = $('#portal-column-content').height()+12; $('#frame-tree').height(cheight-searchform); } $(window).resize(function() { change_size(); }); </script> <meta name="citation_author" content="Wiedmer, Petra"/> <meta name="citation_author" content="Schwarz, Franziska"/> <meta name="citation_author" content="Gro脽e, Birgit"/> <meta name="citation_author" content="Schindler, Nancy"/> <meta name="citation_author" content="Tuchscherer, Armin"/> <meta name="citation_author" content="Russo, Vincenzo C"/> <meta name="citation_author" content="Tsch枚p, Matthias H"/> <meta name="citation_author" content="Hoeflich, Andreas"/> <meta name="citation_title" content="Gender-specific effects on food intake but no inhibition of age-related fat accretion in transgenic mice overexpressing human IGFBP-2 lacking the Cardin-Weintraub sequence motif."/> <meta name="citation_issue" content="2"/> <meta name="citation_volume" content="9"/> <meta name="citation_issn" content="1873-9601"/> <meta name="citation_doi" content="10.1007/s12079-015-0264-z"/> <meta name="citation_firstpage" content="143-50"/> <meta name="citation_publication_date" content="2015"/> <meta name="DC.description" content="IGFBP-2 affects growth and metabolism and is thought to impact on energy homeostasis and the accretion of body fat via its heparin binding domains (HBD). In order to assess the function of the HBD present in the linker domain (HBD1) we have generated transgenic mice overexpressing mutant human IGFBP-2 lacking the PKKLRP sequence and carrying a PNNLAP sequence instead. Transgenic mice expressed high amounts of human IGFBP-2, while endogenous IGFBP-2 or IGF-I serum concentrations were not affected. In both genders we performed a longitudinal analysis of growth and metabolism including at least 4 separate time points between the age of 10 and 52聽weeks. Body composition was assessed by nuclear magnetic resonance (NMR) analysis. Food intake was recorded by an automated online-monitoring. We describe negative effects of mutant human IGFBP-2 on body weight, longitudinal growth and lean body mass (p < 0.05). Very clearly, negative effects of mutant IGFBP-2 were not observed for fat mass accretion throughout life. Instead, relative fat mass was increased in transgenic mice of both genders (p < 0.05). In male mice transgene expression significantly increased absolute mass of total body fat over all age groups (p < 0.05). Food intake was increased in female but decreased in male transgenic mice at an age of 11聽weeks. Thus our study clearly provides gender- and time-specific effects of HBD1-deficient hIGFBP-2 (H1d-BP-2) on fat mass accretion and food intake. While our data are in principal agreement with current knowledge on the role of HB-domains for fat accretion we now may also speculate on a role of HBD1 for the control of eating behavior."/> <link rel="stylesheet" href="/static/css/mediatum-tum-editor.css"/> </head> <body onload="change_size();"> <div id="visual-portal-wrapper"> <div id="portal-top"> <div class="header header-left"> <script type="application/javascript" src="/static/js/webstat.js"></script> <noscript> <p><img src="https://webstat.srv.tum.de/matomo.php?idsite=78&rec=1" style="border:0;" alt="Matomo Image Tracker"/> </p> </noscript> <ul> <li><a href="/" class="mediatum-link-internal">mediaTUM</a> </li> <li><a href="https://www.ub.tum.de" class="mediatum-link-external">Universit盲tsbibliothek</a> </li> <li><a href="https://www.tum.de" class="mediatum-link-external">Technische Universit盲t M眉nchen</a> </li> </ul> </div> <div class="header header-right"><a href="https://tum.de" title="Home tum.de" class="header-logo"><img 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href="/1356433?nodes_per_page=10&result_nav=last"> <div id="mediatum_img_pageright_end"></div></a> </td> </tr> </table><br/> </div>  <link rel="stylesheet" href="/static/css/childs.css"/> <link rel="stylesheet" href="/static/css/jade_style.css"/> <div class="object_main content_container"> <dl class="object_meta object_column"><dt class="mask_label">Titel:</dt> <dd class="mask_value"><h1>Gender-specific effects on food intake but no inhibition of age-related fat accretion in transgenic mice overexpressing human IGFBP-2 lacking the Cardin-Weintraub sequence motif.</h1></dd> <dt class="mask_label">Dokumenttyp:</dt> <dd class="mask_value">Journal Article; Article</dd> <dt class="mask_label">Autor(en):</dt> <dd class="mask_value">Wiedmer, Petra; Schwarz, Franziska; Gro脽e, Birgit; Schindler, Nancy; Tuchscherer, Armin; Russo, Vincenzo C; Tsch枚p, Matthias H; Hoeflich, Andreas</dd> <dt class="mask_label">Abstract:</dt> <dd class="mask_value">IGFBP-2 affects growth and metabolism and is thought to impact on energy homeostasis and the accretion of body fat via its heparin binding domains (HBD). In order to assess the function of the HBD present in the linker domain (HBD1) we have generated transgenic mice overexpressing mutant human IGFBP-2 lacking the PKKLRP sequence and carrying a PNNLAP sequence instead. Transgenic mice expressed high amounts of human IGFBP-2, while endogenous IGFBP-2 or IGF-I serum concentrations were not affected. In both genders we performed a longitudinal analysis of growth and metabolism including at least 4 separate time points between the age of 10 and 52聽weeks. Body composition was assessed by nuclear magnetic resonance (NMR) analysis. Food intake was recorded by an automated online-monitoring. We describe negative effects of mutant human IGFBP-2 on body weight, longitudinal growth and lean body mass (p < 0.05). Very clearly, negative effects of mutant IGFBP-2 were not observed for fat mass accretion throughout life. Instead, relative fat mass was increased in transgenic mice of both genders (p < 0.05). In male mice transgene expression significantly increased absolute mass of total body fat over all age groups (p < 0.05). Food intake was increased in female but decreased in male transgenic mice at an age of 11聽weeks. Thus our study clearly provides gender- and time-specific effects of HBD1-deficient hIGFBP-2 (H1d-BP-2) on fat mass accretion and food intake. While our data are in principal agreement with current knowledge on the role of HB-domains for fat accretion we now may also speculate on a role of HBD1 for the control of eating behavior.</dd> <dt class="mask_label">Zeitschriftentitel:</dt> <dd class="mask_value">J Cell Commun Signal</dd> <dt class="mask_label">Jahr:</dt> <dd class="mask_value">2015</dd> <dt class="mask_label">Band / Volume:</dt> <dd class="mask_value">9</dd> <dt class="mask_label">Heft / Issue:</dt> <dd class="mask_value">2</dd> <dt class="mask_label">Seitenangaben Beitrag:</dt> <dd class="mask_value">143-50</dd> <dt class="mask_label">Sprache:</dt> <dd class="mask_value">eng</dd> <dt class="mask_label">Volltext / DOI:</dt> <dd class="mask_value"><a href="https://doi.org/10.1007/s12079-015-0264-z" target="_blank" title="In neuem Fenster anzeigen" class="mediatum-link-external">doi:10.1007/s12079-015-0264-z</a></dd> <dt class="mask_label">PubMed:</dt> <dd class="mask_value"><a href="http://view.ncbi.nlm.nih.gov/pubmed/25663268" target="_blank" title="In neuem Fenster anzeigen" class="mediatum-link-external">http://view.ncbi.nlm.nih.gov/pubmed/25663268</a></dd> <dt class="mask_label">Print-ISSN:</dt> <dd class="mask_value">1873-9601</dd> <dt class="mask_label">TUM Einrichtung:</dt> <dd class="mask_value">Kliniken und Institute</dd> <dt class="action_icon"><a href="/export/1356485/bibtex" target="bibtexdocument" title="BibTeX Informationen in neuem Fenster 枚ffnen" class="mediatum-link-mediatum"><img src="/static/img/bibtex.gif" class="mediatum-icon-small"/> BibTeX</a> </dt> </dl>  <div class="clear"></div> </div> <div class="clear"></div>  <div id="paths"><b>Vorkommen:</b><br/> <ul> <li><a href="/604993" class="breadcrumb-delimiter mediatum-link-mediatum">mediaTUM Gesamtbestand</a><a href="/670273" class="breadcrumb-delimiter mediatum-link-mediatum">Einrichtungen</a><a href="/670274" class="breadcrumb-delimiter mediatum-link-mediatum">Schools </a><a href="/680583" class="breadcrumb-delimiter mediatum-link-mediatum">TUM School of Medicine and Health</a><a href="/1722655" class="breadcrumb-delimiter mediatum-link-mediatum">Departments</a><a href="/1356433" class="mediatum-link-mediatum">2015</a> </li> </ul> </div>  </div> <div style="clear:both;"></div> </div> <div style="clear:both"></div> <div id="footer"><span class="footer_left"><a href="mailto:mediatum@ub.tum.de" class="customcontent mediatum-link-external">mediatum@ub.tum.de</a><a href="/?item=604993_15.html" class="customcontent mediatum-link-internal">Kontakt</a><a href="/?item=604993_17.html" class="customcontent mediatum-link-internal">脺ber mediaTUM</a><a href="/?item=604993_14.html" class="customcontent mediatum-link-internal">Hilfe</a></span><span class="footer_right"><a href="/?item=604993_12.html" class="customcontent mediatum-link-internal">Nutzungsrechte</a><a href="/?item=604993_9.html" class="customcontent mediatum-link-internal">Datenschutz</a><a href="/?item=604993_18.html" class="customcontent mediatum-link-internal">Barrierefreiheit</a><a href="https://www.ub.tum.de/impressum" class="customcontent mediatum-link-external">Impressum</a></span> </div> </div> </body> </html>