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<a href="https://www.oxlumohcp.com/" class="hide show-oxlumo-hcp js-open-corp menu__link">OXLUMOHCP.COM</a> </li> </ul>  </nav>      <nav role="navigation" aria-labelledby="block-mobilebuttons-menu" id="block-mobilebuttons" class="hide max-lg-block block block-menu navigation menu--mobile-buttons"> <h2 class="visually-hidden" id="block-mobilebuttons-menu">Mobile buttons</h2>     <ul class="menu menu--level-1"> <li class="menu__item menu__item--link menu__item--level-1"> <a href="tel:1-833-256-2748" class="button white menu__link">Call Us</a> </li> <li class="menu__item menu__item--link menu__item--level-1"> <a href="#product_prompt" class="button teal js-open-modal menu__link">Enroll Patient ›</a> </li> </ul>  </nav>  </div> </div>  </div> </header> <main role="main"> <a id="main-content" tabindex="-1"></a>     <div class="region region-highlighted">     <div data-drupal-messages-fallback class="hidden"></div>  </div>  <div class="layout-content">     <div class="region region-content">     <div id="block-assist-content" class="block block-system block-system-main-block">     <article class="node node--type-page node--view-mode-full"> <div class="node__content">     <div class="layout layout--onecol"> <div class="layout__region layout__region--content">     <div class="block block-layout-builder block-field-blocknodepagebody">     <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"></div>  </div>      <div class="block block-layout-builder block-extra-field-blocknodepagelinks">      </div>      <div class="block block-layout-builder block-field-blocknodepagefield-section">     <div class="field-sections">     <section class="intro" > <div class="wrapper">     <div class="text-formatted field field--name-field-content field--type-text-long field--label-hidden field__items"> <div class="field__item"><hr class="divider"><h2 class="text-align-center">Alnylam Assist® Online Start Form</h2><p>Help your patients get started on ONPATTRO® (patisiran) by filling out the online Start Form together.</p><p>The purpose of this form is to permit Alnylam Assist® participants to receive additional information and support (“Patient Support”) from Alnylam Pharmaceuticals, Inc., its affiliates, representatives, agents, and contractors (“Alnylam”). Alnylam Assist® provides Patient Support to eligible patients who have been prescribed an Alnylam medicine. This includes: (1) providing reimbursement and financial support to eligible patients (such as investigating your patient's insurance coverage, confirming out-of-pocket costs, and reviewing eligibility for financial assistance); (2) working with you and your provider to fill your prescription; and (3) providing you with disease and medication-related educational resources and communications. Your authorization in this form will relate to information and support with respect to any Alnylam medicine you have been prescribed or may be prescribed in the future.</p><p>PLEASE NOTE: Consent via electronic signature is mandatory for submission of the form. Forms must be submitted once started, as progress will not be saved. The online Start Form below should only be used if you and the patient are filling it out together currently. If not, please <a href="https://na3.docusign.net/Member/PowerFormSigning.aspx?PowerFormId=a9c33a88-e0a7-4df0-91f0-56078d72202d" target="_blank">click here</a> to go to DocuSign, where you can complete your portion and it will then be emailed to your patient for their portion.</p></div> </div>  </div> </section>      <div class="paragraph paragraph--type--webform paragraph--view-mode--default">     <div class="field field--name-field-webform field--type-webform field--label-hidden field__item">     <form class="webform-submission-form webform-submission-add-form webform-submission-onpattro-hcp-start-form-form webform-submission-onpattro-hcp-start-form-add-form webform-submission-onpattro-hcp-start-form-paragraph-4539-form webform-submission-onpattro-hcp-start-form-paragraph-4539-add-form start-form js-webform-disable-autosubmit js-webform-details-toggle webform-details-toggle" data-drupal-selector="webform-submission-onpattro-hcp-start-form-paragraph-4539-add-form" action="/hcp/onpattro/webform" method="post" id="webform-submission-onpattro-hcp-start-form-paragraph-4539-add-form" accept-charset="UTF-8">         <div class="webform-progress">     <ul class="webform-progress-tracker progress-tracker" data-webform-progress-steps> <li data-webform-page="patient_information" title="Patient Information" class="progress-step is-active" aria-current="step"> <div class="progress-marker" data-webform-progress-step data-webform-progress-link data-text="1"></div> <div class="progress-text"> <div class="progress-title" data-webform-progress-link> <span class="visually-hidden" data-webform-progress-state>Current</span> Patient Information </div> </div> </li> <li data-webform-page="insurance_information" title="Insurance Information" class="progress-step"> <div class="progress-marker" data-webform-progress-step data-webform-progress-link data-text="2"></div> <div class="progress-text"> <div class="progress-title" data-webform-progress-link> <span class="visually-hidden" data-webform-progress-state></span> Insurance Information </div> </div> </li> <li data-webform-page="patient_authorization" title="Patient Authorization" class="progress-step"> <div class="progress-marker" data-webform-progress-step data-webform-progress-link data-text="3"></div> <div class="progress-text"> <div class="progress-title" data-webform-progress-link> <span class="visually-hidden" data-webform-progress-state></span> Patient Authorization </div> </div> </li> <li data-webform-page="physician_information" title="Prescriber Information " class="progress-step"> <div class="progress-marker" data-webform-progress-step data-webform-progress-link data-text="4"></div> <div class="progress-text"> <div class="progress-title" data-webform-progress-link> <span class="visually-hidden" data-webform-progress-state></span> Prescriber Information </div> </div> </li> <li data-webform-page="onpattro_prescription" title="Dosing Information" class="progress-step"> <div class="progress-marker" data-webform-progress-step data-webform-progress-link data-text="5"></div> <div class="progress-text"> <div class="progress-title" data-webform-progress-link> <span class="visually-hidden" data-webform-progress-state></span> Dosing Information </div> </div> </li> <li data-webform-page="confirm_submit" title="Confirm & Submit" class="progress-step"> <div class="progress-marker" data-webform-progress-step data-webform-progress-link data-text="6"></div> <div class="progress-text"> <div class="progress-title" data-webform-progress-link> <span class="visually-hidden" data-webform-progress-state></span> Confirm & Submit </div> </div> </li> </ul>  </div>      <div data-webform-key="patient_information" data-drupal-selector="edit-patient-information" id="edit-patient-information" class="js-form-wrapper form-wrapper">     <div class="top-inner-container js-form-wrapper form-wrapper" data-drupal-selector="edit-container" id="edit-container">     <div class="w-full mt-7 js-form-item form-item js-form-type-webform-markup form-type-webform-markup js-form-item-markup-01 form-item-markup-01 form-no-label" id="edit-markup-01">    <h2>Patient Information</h2>  </div>      <div class="w-full js-form-item form-item js-form-type-webform-markup form-type-webform-markup js-form-item-markup-02 form-item-markup-02 form-no-label" id="edit-markup-02">    <span class="requiredstep">*Indicates required field </span>  </div>  </div>     <hr data-drupal-selector="edit-horizontal-rule" id="edit-horizontal-rule" class="webform-horizontal-rule" />      <div class="inner-container js-form-wrapper form-wrapper" data-drupal-selector="edit-inner-container" id="edit-inner-container">     <div class="md:w-2/5 js-form-item form-item js-form-type-textfield form-type-textfield js-form-item-first-name form-item-first-name">    <label for="edit-first-name" class="js-form-required form-required">First Name</label>      <input data-drupal-selector="edit-first-name" data-msg-required="First Name field is required." data-msg-maxlength="First Name field has a maximum length of 255." type="text" id="edit-first-name" name="first_name" value="" size="60" maxlength="255" class="form-text required" required="required" aria-required="true" />  </div>      <div class="md:w-1/6 js-form-item form-item js-form-type-textfield form-type-textfield js-form-item-middle-name form-item-middle-name">    <label for="edit-middle-name">Middle Name</label>      <input data-drupal-selector="edit-middle-name" data-msg-maxlength="Middle Name field has a maximum length of 255." type="text" id="edit-middle-name" name="middle_name" value="" size="60" maxlength="255" class="form-text" />  </div>      <div class="md:w-2/5 js-form-item form-item js-form-type-textfield form-type-textfield js-form-item-last-name form-item-last-name">    <label for="edit-last-name" class="js-form-required form-required">Last Name</label>      <input data-drupal-selector="edit-last-name" data-msg-required="Last Name field is required." data-msg-maxlength="Last Name field has a maximum length of 255." type="text" id="edit-last-name" name="last_name" value="" size="60" maxlength="255" class="form-text required" required="required" aria-required="true" />  </div>      <div class="md:w-1/4 js-form-item form-item js-form-type-date form-type-date js-form-item-date-of-birth-mm-dd-yyyy- form-item-date-of-birth-mm-dd-yyyy-">    <label for="edit-date-of-birth-mm-dd-yyyy-" class="js-form-required form-required">Date of Birth (MM/DD/YYYY)</label>      <input type="date" data-drupal-selector="edit-date-of-birth-mm-dd-yyyy-" data-msg-required="Date of Birth (MM/DD/YYYY) field is required." id="edit-date-of-birth-mm-dd-yyyy-" name="date_of_birth_mm_dd_yyyy_" value="" class="form-date required" required="required" aria-required="true" />  </div>      <div class="md:w-2/5 js-form-item form-item js-form-type-email form-type-email js-form-item-email form-item-email">    <label for="edit-email" class="js-form-required form-required">Email</label>      <input data-drupal-selector="edit-email" data-msg-required="Email field is required." data-msg-email="Email does not contain a valid email." data-msg-maxlength="Email field has a maximum length of 254." type="email" id="edit-email" name="email" value="" size="60" maxlength="254" class="form-email required" required="required" aria-required="true" />  </div>      <div class="md:w-4/5 js-form-item form-item js-form-type-textfield form-type-textfield js-form-item-street-address- form-item-street-address-">    <label for="edit-street-address-" class="js-form-required form-required">Street Address </label>      <input data-drupal-selector="edit-street-address-" data-msg-required="Street Address field is required." data-msg-maxlength="Street Address field has a maximum length of 255." type="text" id="edit-street-address-" name="street_address_" value="" size="60" maxlength="255" class="form-text required" required="required" aria-required="true" />  </div>      <div class="md:w-4/5 js-form-item form-item js-form-type-textfield form-type-textfield js-form-item-city form-item-city">    <label for="edit-city" class="js-form-required form-required">City</label>      <input data-drupal-selector="edit-city" data-msg-required="City field is required." data-msg-maxlength="City field has a maximum length of 255." type="text" id="edit-city" name="city" value="" size="60" maxlength="255" class="form-text required" required="required" aria-required="true" />  </div>      <div class="md:w-1/3 js-form-item form-item js-form-type-select form-type-select js-form-item-state form-item-state">    <label for="edit-state" class="js-form-required form-required">State</label>     <select data-drupal-selector="edit-state" data-msg-required="State field is required." id="edit-state" name="state" class="form-select required" required="required" aria-required="true"><option value="" selected="selected">Please select</option><option value="Alabama">Alabama</option><option value="Alaska">Alaska</option><option value="Arizona">Arizona</option><option value="Arkansas">Arkansas</option><option value="California">California</option><option value="Colorado">Colorado</option><option value="Connecticut">Connecticut</option><option value="Delaware">Delaware</option><option value="District of Columbia">District of Columbia</option><option value="Florida">Florida</option><option value="Georgia">Georgia</option><option value="Hawaii">Hawaii</option><option value="Idaho">Idaho</option><option value="Illinois">Illinois</option><option value="Indiana">Indiana</option><option value="Iowa">Iowa</option><option value="Kansas">Kansas</option><option value="Kentucky">Kentucky</option><option value="Louisiana">Louisiana</option><option value="Maine">Maine</option><option value="Maryland">Maryland</option><option value="Massachusetts">Massachusetts</option><option value="Michigan">Michigan</option><option value="Minnesota">Minnesota</option><option value="Mississippi">Mississippi</option><option value="Missouri">Missouri</option><option value="Montana">Montana</option><option value="Nebraska">Nebraska</option><option value="Nevada">Nevada</option><option value="New Hampshire">New Hampshire</option><option value="New Jersey">New Jersey</option><option value="New Mexico">New Mexico</option><option value="New York">New York</option><option value="North Carolina">North Carolina</option><option value="North Dakota">North Dakota</option><option value="Ohio">Ohio</option><option value="Oklahoma">Oklahoma</option><option value="Oregon">Oregon</option><option value="Pennsylvania">Pennsylvania</option><option value="Rhode Island">Rhode Island</option><option value="South Carolina">South Carolina</option><option value="South Dakota">South Dakota</option><option value="Tennessee">Tennessee</option><option value="Texas">Texas</option><option value="Utah">Utah</option><option value="Vermont">Vermont</option><option value="Virginia">Virginia</option><option value="Washington">Washington</option><option value="West Virginia">West Virginia</option><option value="Wisconsin">Wisconsin</option><option value="Wyoming">Wyoming</option></select>  </div>      <div class="md:w-2/5 js-form-item form-item js-form-type-textfield form-type-textfield js-form-item-zip form-item-zip">    <label for="edit-zip" class="js-form-required form-required">Zip</label>      <input data-inputmask-mask="99999[-9999]" class="js-webform-input-mask form-text required" pattern="^\d\d\d\d\d(-\d\d\d\d)?$" data-drupal-selector="edit-zip" data-msg-required="Zip field is required." data-msg-maxlength="Zip field has a maximum length of 255." data-msg-pattern="Zip does not meet the requirements." type="text" id="edit-zip" name="zip" value="" size="60" maxlength="255" required="required" aria-required="true" />  </div>     <section class="md:w-1/3 js-form-item form-item js-form-wrapper form-wrapper webform-section" data-drupal-selector="edit-preferred-phone-number-box" id="edit-preferred-phone-number-box"> <h2 class="visually-hidden webform-section-title">Preferred Phone Number Box</h2> <div class="webform-section-wrapper">     <div class="js-form-item form-item js-form-type-textfield form-type-textfield js-form-item-primary-phone-number form-item-primary-phone-number">    <label for="edit-primary-phone-number" class="js-form-required form-required">Preferred Phone Number</label>      <input data-inputmask-mask="(999) 999-9999" class="js-webform-input-mask form-text required" pattern="^$\d\d\d$ \d\d\d-\d\d\d\d$" data-drupal-selector="edit-primary-phone-number" data-msg-required="Preferred Phone Number field is required." data-msg-maxlength="Preferred Phone Number field has a maximum length of 255." data-msg-pattern="Preferred Phone Number does not meet the requirements." type="text" id="edit-primary-phone-number" name="primary_phone_number" value="" size="60" maxlength="255" required="required" aria-required="true" />  </div>      <div class="js-form-item form-item js-form-type-checkbox form-type-checkbox js-form-item-okay-to-leave-voicemail form-item-okay-to-leave-voicemail">     <input data-drupal-selector="edit-okay-to-leave-voicemail" type="checkbox" id="edit-okay-to-leave-voicemail" name="okay_to_leave_voicemail" value="1" class="form-checkbox" />     <label for="edit-okay-to-leave-voicemail" class="option">Okay to leave voicemail on preferred phone number</label>  </div>  </div> </section>     <section class="md:w-1/3 js-form-item form-item js-form-wrapper form-wrapper webform-section" data-drupal-selector="edit-alternative-phone-number-section" id="edit-alternative-phone-number-section"> <h2 class="visually-hidden webform-section-title">Alternative Phone Number Section</h2> <div class="webform-section-wrapper">     <div class="js-form-item form-item js-form-type-textfield form-type-textfield js-form-item-preferred-phone-number-if-different-than-primary- form-item-preferred-phone-number-if-different-than-primary-">    <label for="edit-preferred-phone-number-if-different-than-primary-">Alternative Phone Number</label>      <input data-inputmask-mask="(999) 999-9999" class="js-webform-input-mask form-text" pattern="^$\d\d\d$ \d\d\d-\d\d\d\d$" data-drupal-selector="edit-preferred-phone-number-if-different-than-primary-" data-msg-maxlength="Alternative Phone Number field has a maximum length of 255." data-msg-pattern="Alternative Phone Number does not meet the requirements." type="text" id="edit-preferred-phone-number-if-different-than-primary-" name="preferred_phone_number_if_different_than_primary_" value="" size="60" maxlength="255" />  </div>      <div class="js-form-item form-item js-form-type-checkbox form-type-checkbox js-form-item--span-class-okay2leave-checkbox-okay-to-leave-voicemail__span- form-item--span-class-okay2leave-checkbox-okay-to-leave-voicemail__span-">     <input data-drupal-selector="edit-span-class-okay2leave-checkbox-okay-to-leave-voicemail-span-" type="checkbox" id="edit-span-class-okay2leave-checkbox-okay-to-leave-voicemail-span-" name="_span_class_okay2leave_checkbox_okay_to_leave_voicemail__span_" value="1" class="form-checkbox" />     <label for="edit-span-class-okay2leave-checkbox-okay-to-leave-voicemail-span-" class="option">Okay to leave voicemail on alternative phone number</label>  </div>  </div> </section>      <div class="w-full mt-12 js-form-item form-item js-form-type-webform-markup form-type-webform-markup js-form-item-markup form-item-markup form-no-label" id="edit-markup">    <h5>Caregiver Information (Optional)</h5>  </div>      <div class="md:w-1/2 js-form-item form-item js-form-type-textfield form-type-textfield js-form-item-first-name-1 form-item-first-name-1">    <label for="edit-first-name-1">First Name</label>      <input data-drupal-selector="edit-first-name-1" data-msg-maxlength="First Name field has a maximum length of 255." type="text" id="edit-first-name-1" name="first_name_1" value="" size="60" maxlength="255" class="form-text" />  </div>      <div class="md:w-1/2 js-form-item form-item js-form-type-textfield form-type-textfield js-form-item-last-name-1 form-item-last-name-1">    <label for="edit-last-name-1">Last Name</label>      <input data-drupal-selector="edit-last-name-1" data-msg-maxlength="Last Name field has a maximum length of 255." type="text" id="edit-last-name-1" name="last_name_1" value="" size="60" maxlength="255" class="form-text" />  </div>      <div class="md:w-1/2 js-form-item form-item js-form-type-email form-type-email js-form-item-caregiver-email form-item-caregiver-email">    <label for="edit-caregiver-email">Caregiver Email</label>      <input data-drupal-selector="edit-caregiver-email" data-msg-email="Caregiver Email does not contain a valid email." data-msg-maxlength="Caregiver Email field has a maximum length of 254." type="email" id="edit-caregiver-email" name="caregiver_email" value="" size="60" maxlength="254" class="form-email" />  </div>      <div class="md:w-1/2 js-form-item form-item js-form-type-textfield form-type-textfield js-form-item-relationship-to-patient form-item-relationship-to-patient">    <label for="edit-relationship-to-patient">Relationship to Patient</label>      <input data-drupal-selector="edit-relationship-to-patient" data-msg-maxlength="Relationship to Patient field has a maximum length of 255." type="text" id="edit-relationship-to-patient" name="relationship_to_patient" value="" size="60" maxlength="255" class="form-text" />  </div>      <div class="md:w-1/2 js-form-item form-item js-form-type-textfield form-type-textfield js-form-item-phone-number form-item-phone-number">    <label for="edit-phone-number">Caregiver Phone</label>      <input data-inputmask-mask="(999) 999-9999" class="js-webform-input-mask form-text" pattern="^$\d\d\d$ \d\d\d-\d\d\d\d$" data-drupal-selector="edit-phone-number" data-msg-maxlength="Caregiver Phone field has a maximum length of 255." data-msg-pattern="Caregiver Phone does not meet the requirements." type="text" id="edit-phone-number" name="phone_number" value="" size="60" maxlength="255" />  </div>      <div class="md:w-1/2 mt-7 js-form-item form-item js-form-type-checkbox form-type-checkbox js-form-item-okay-to-leave-voicemail-caregiver form-item-okay-to-leave-voicemail-caregiver">     <input data-drupal-selector="edit-okay-to-leave-voicemail-caregiver" type="checkbox" id="edit-okay-to-leave-voicemail-caregiver" name="okay_to_leave_voicemail_caregiver" value="1" class="form-checkbox" />     <label for="edit-okay-to-leave-voicemail-caregiver" class="option">Okay to leave voicemail</label>  </div>      <div class="w-full mt-12 js-form-item form-item js-form-type-webform-markup form-type-webform-markup js-form-item-markup-03 form-item-markup-03 form-no-label" id="edit-markup-03">    <h5>Additional Patient Information</h5>  </div>     <fieldset data-drupal-selector="edit-language-translation-" class="md:w-1/3 radios--wrapper fieldgroup form-composite webform-composite-visible-title js-webform-type-radios webform-type-radios js-form-item form-item js-form-wrapper form-wrapper" id="edit-language-translation---wrapper"> <legend id="edit-language-translation---wrapper-legend"> <span class="fieldset-legend">Language translation?</span> </legend> <div class="fieldset-wrapper">    <div id="edit-language-translation-" class="js-webform-radios webform-options-display-side-by-side form-radios">     <div class="js-form-item form-item js-form-type-radio form-type-radio js-form-item-language-translation- form-item-language-translation-">     <input data-drupal-selector="edit-language-translation-yes" type="radio" id="edit-language-translation-yes" name="language_translation_" value="Yes" class="form-radio" />     <label for="edit-language-translation-yes" class="option">Yes</label>  </div>      <div class="js-form-item form-item js-form-type-radio form-type-radio js-form-item-language-translation- form-item-language-translation-">     <input data-drupal-selector="edit-language-translation-no" type="radio" id="edit-language-translation-no" name="language_translation_" value="No" class="form-radio" />     <label for="edit-language-translation-no" class="option">No</label>  </div>  </div>  </div> </fieldset>      <div class="md:w-2/3 js-form-item form-item js-form-type-textfield form-type-textfield js-form-item-if-yes-please-indicate-language- form-item-if-yes-please-indicate-language-">    <label for="edit-if-yes-please-indicate-language-">If yes, please indicate language:</label>      <input data-drupal-selector="edit-if-yes-please-indicate-language-" data-msg-maxlength="If yes, please indicate language: field has a maximum length of 255." type="text" id="edit-if-yes-please-indicate-language-" name="if_yes_please_indicate_language_" value="" size="60" maxlength="255" class="form-text" />  </div>      <div class="pb-0 mb-0 mt-0 js-form-item form-item js-form-type-processed-text form-type-processed-text js-form-item- form-item- form-no-label" id="edit-ga1"> <script> window.dataLayer = window.dataLayer || []; window.dataLayer.push({ 'typeCategory': 'Form', 'typeAction': 'Online Start Form', 'typeLabel': 'Step 1 - Patient Information' }); </script> </div>  </div>  </div>      <input autocomplete="off" data-drupal-selector="form-0kjnenl5vluove5ibnfupqosaay1-op84d1qzcanqle" type="hidden" name="form_build_id" value="form-0kJnEnL5VLUOVE5IbnFUpQOsaAY1-Op84D1qZCANqLE" />      <input data-drupal-selector="edit-webform-submission-onpattro-hcp-start-form-paragraph-4539-add-form" type="hidden" name="form_id" value="webform_submission_onpattro_hcp_start_form_paragraph_4539_add_form" />      <div data-drupal-selector="edit-actions" class="form-actions js-form-wrapper form-wrapper" id="edit-actions">        <input class="webform-button--next button js-form-submit form-submit" data-drupal-selector="edit-wizard-next" type="submit" id="edit-wizard-next" name="op" value="Continue" />   </div>   </form>  </div>  </div>  </div>  </div>      <div class="block block-layout-builder block-extra-field-blocknodepagecontent-moderation-control"> </div>  </div> </div>  </div> </article>  </div>      <div id="block-connectcallouthcp" class="block-content block-contentc454f69d-4dfe-4632-87ce-c43a462fc38e">     <div class="field-sections">     <section class="connect callout left-navy third-over long-btm-first" > <div class="wrapper">     <div class="text-formatted field field--name-field-content field--type-text-long field--label-hidden field__items"> <div class="field__item"><h2>Have Questions?</h2><p class="font-serif text-xl"><strong>Alnylam Case Managers</strong> <br /><strong>are here to help your patients</strong> <br /><strong>with an Alnylam product.</strong></p><p>If you or your office staff have questions, <br />call us at:</p><p class="font-serif"><strong>1-833-256-2748</strong> <br /><strong>Monday–Friday, 8am–6pm</strong></p>     <article class="hide max-sm:block align-center media media--type-image media--view-mode-default"><div class="field field--name-field-media-image field--type-image field--label-visually_hidden"> <div class="field__label visually-hidden">Image</div> <div class="field__item">       <img src="/sites/default/files/2023-06/connect-mobile.png" width="343" height="251" alt="Alnylam Case Manager" loading="lazy" /></div> </div>  </article></div> <div class="field__item">     <article class="mb-24 max-sm:hidden align-center media media--type-image media--view-mode-default"><div class="field field--name-field-media-image field--type-image field--label-visually_hidden"> <div class="field__label visually-hidden">Image</div> <div class="field__item">       <img src="/sites/default/files/2023-05/connect-with-casemanager.jpg" width="532" height="388" alt="Alnylam Case Manager" loading="lazy" /></div> </div>  </article></div> <div class="field__item">     <article class="mb-24 max-xs:hidden align-center media media--type-image media--view-mode-default"><div class="field field--name-field-media-image field--type-image field--label-visually_hidden"> <div class="field__label visually-hidden">Image</div> <div class="field__item">       <img src="/sites/default/files/2023-05/text-connect.svg" alt="Connect" loading="lazy" /></div> </div>  </article></div> </div>  </div> </section>  </div>  </div>  </div>  </div> </main> <div class="before_footer">     <div class="region region-before-footer">     <div id="block-assist-isionpattrohcp" class="isi block-content block-content7f18b423-83ce-4ae0-9201-60ec5c88cc00">     <div class="layout layout--onecol"> <div class="layout__region layout__region--content">     <div class="block block-layout-builder block-field-blockblock-contentbasicbody">     <div class="text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><div class="close-isi"> </div><div class="open-isi"> </div><h3>Important Safety Information and Indication</h3><h3>Important Safety Information</h3><p><strong>Infusion-Related Reactions</strong> <br>Infusion-related reactions (IRRs) have been observed in patients treated with ONPATTRO® (patisiran). In a controlled clinical study, 19% of ONPATTRO-treated patients experienced IRRs, compared to 9% of placebo-treated patients. The most common symptoms of IRRs with ONPATTRO were flushing, back pain, nausea, abdominal pain, dyspnea, and headache.</p><p>To reduce the risk of IRRs, patients should receive premedication with a corticosteroid, acetaminophen, and antihistamines (H1 and H2 blockers) at least 60 minutes prior to ONPATTRO infusion. Monitor patients during the infusion for signs and symptoms of IRRs. If an IRR occurs, consider slowing or interrupting the infusion and instituting medical management as clinically indicated. If the infusion is interrupted, consider resuming at a slower infusion rate only if symptoms have resolved. In the case of a serious or life-threatening IRR, the infusion should be discontinued and not resumed.</p><h5>Reduced Serum Vitamin A Levels and Recommended Supplementation</h5><p>ONPATTRO treatment leads to a decrease in serum vitamin A levels. Supplementation at the recommended daily allowance (RDA) of vitamin A is advised for patients taking ONPATTRO. Higher doses than the RDA should not be given to try to achieve normal serum vitamin A levels during treatment with ONPATTRO, as serum levels do not reflect the total vitamin A in the body.</p><p>Patients should be referred to an ophthalmologist if they develop ocular symptoms suggestive of vitamin A deficiency (e.g. night blindness).</p><h5>Adverse Reactions</h5><p>The most common adverse reactions that occurred in patients treated with ONPATTRO were upper respiratory tract infections (29%) and infusion-related reactions (19%).</p><h3>Indication</h3><p>ONPATTRO is indicated for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults.</p><p><strong>For additional information about ONPATTRO, please see the full </strong><a class="new-window" href="https://www.alnylam.com/sites/default/files/pdfs/onpattro-us-prescribing-information.pdf" target="_blank"><strong>Prescribing Information</strong></a><strong>.</strong></p><p><strong> </strong></p></div>  </div>      <div class="block block-layout-builder block-extra-field-blockblock-contentbasiccontent-moderation-control"> </div>  </div> </div>  </div>  </div>  </div> <footer role="contentinfo">     <div class="region region-footer">     <nav role="navigation" aria-labelledby="block-sitelinks-menu" id="block-sitelinks" class="max-xs-hidden block block-menu navigation menu--site-links"> <h2 class="visually-hidden" id="block-sitelinks-menu">Site links - 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