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Unsourced material may be challenged and removed.<br /><small><span class="plainlinks"><i>Find sources:</i> <a rel="nofollow" class="external text" href="https://www.google.com/search?as_eq=wikipedia&q=%22Complement+receptor%22">"Complement receptor"</a> – <a rel="nofollow" class="external text" href="https://www.google.com/search?tbm=nws&q=%22Complement+receptor%22+-wikipedia&tbs=ar:1">news</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.google.com/search?&q=%22Complement+receptor%22&tbs=bkt:s&tbm=bks">newspapers</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.google.com/search?tbs=bks:1&q=%22Complement+receptor%22+-wikipedia">books</a> <b>·</b> <a rel="nofollow" class="external text" href="https://scholar.google.com/scholar?q=%22Complement+receptor%22">scholar</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.jstor.org/action/doBasicSearch?Query=%22Complement+receptor%22&acc=on&wc=on">JSTOR</a></span></small></span> <span class="date-container"><i>(<span class="date">September 2008</span>)</i></span><span class="hide-when-compact"><i> (<small><a href="/wiki/Help:Maintenance_template_removal" title="Help:Maintenance template removal">Learn how and when to remove this message</a></small>)</i></span></div></td></tr></tbody></table> <p class="mw-empty-elt"> </p> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">Complement receptor</th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee">Complement receptor</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Membranome_database" title="Membranome database">Membranome</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="http://membranome.org/protein_families/116">116</a></td></tr></tbody></table> <p>A <b>complement receptor</b> is a membrane-bound <a href="/wiki/Receptor_(biochemistry)" title="Receptor (biochemistry)">receptor</a> belonging to the <a href="/wiki/Complement_system" title="Complement system">complement system</a>, which is part of the <a href="/wiki/Innate_immune_system" title="Innate immune system">innate immune system</a>. Complement receptors bind <a href="/wiki/Effector_(biology)" title="Effector (biology)">effector</a> <a href="/wiki/Protein" title="Protein">protein</a> fragments that are produced in response to antigen-antibody complexes or damage-associated molecules.<sup id="cite_ref-ar14_1-0" class="reference"><a href="#cite_note-ar14-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Complement receptor activation contributes to the regulation of <a href="/wiki/Inflammation" title="Inflammation">inflammation</a>, <a href="/wiki/Leukocyte_extravasation" title="Leukocyte extravasation">leukocyte extravasation</a>, and <a href="/wiki/Phagocytosis" title="Phagocytosis">phagocytosis</a>; it also contributes to the <a href="/wiki/Adaptive_immune_system" title="Adaptive immune system">adaptive immune response</a>.<sup id="cite_ref-cr17_2-0" class="reference"><a href="#cite_note-cr17-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid19388161_3-0" class="reference"><a href="#cite_note-pmid19388161-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Different complement receptors can participate in either the <a href="/wiki/Classical_complement_pathway" title="Classical complement pathway">classical complement pathway</a>, the <a href="/wiki/Alternative_complement_pathway" title="Alternative complement pathway">alternative complement pathway</a>, or both.<sup id="cite_ref-Janeway_2001_4-0" class="reference"><a href="#cite_note-Janeway_2001-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Expression_and_function">Expression and function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Complement_receptor&action=edit&section=1" title="Edit section: Expression and function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/White_blood_cell" title="White blood cell">White blood cells</a>, particularly <a href="/wiki/Monocyte" title="Monocyte">monocytes</a> and <a href="/wiki/Macrophage" title="Macrophage">macrophages</a>, <a href="/wiki/Gene_expression" title="Gene expression">express</a> complement receptors on their surface. All four complement receptors can bind to fragments of <a href="/wiki/Complement_component_3" title="Complement component 3">complement component 3</a> or <a href="/wiki/Complement_component_4" title="Complement component 4">complement component 4</a> coated on pathogen surface, but the receptors trigger different downstream activities.<sup id="cite_ref-ar14_1-1" class="reference"><a href="#cite_note-ar14-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Complement receptor (CR) 1, 3, and 4 function as <a href="/wiki/Opsonin" title="Opsonin">opsonins</a> which stimulate <a href="/wiki/Phagocytosis" title="Phagocytosis">phagocytosis</a>, whereas CR2 is expressed only on <a href="/wiki/B_cell" title="B cell">B cells</a> as a <a href="/wiki/Co-receptor" title="Co-receptor">co-receptor</a>. </p><p><a href="/wiki/Red_blood_cell" title="Red blood cell">Red blood cells</a> (RBCs) also express CR1, which enables RBCs to carry complement-bound <a href="/wiki/Antigen-antibody_complex" class="mw-redirect" title="Antigen-antibody complex">antigen-antibody complexes</a> to the <a href="/wiki/Liver" title="Liver">liver</a> and <a href="/wiki/Spleen" title="Spleen">spleen</a> for degradation.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <table class="wikitable"> <tbody><tr> <th>CR #</th> <th>Name</th> <th>Molecular weight (Da, approx.)<sup id="cite_ref-ar14_1-2" class="reference"><a href="#cite_note-ar14-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></th> <th><a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">Ligand</a><sup id="cite_ref-Janeway_2001_4-1" class="reference"><a href="#cite_note-Janeway_2001-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></th> <th><a href="/wiki/Cluster_of_differentiation" title="Cluster of differentiation">CD</a></th> <th>Major cell types<sup id="cite_ref-Janeway_2001_4-2" class="reference"><a href="#cite_note-Janeway_2001-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup class="plainlinks nourlexpansion citation" id="ref_A"><a href="#endnote_A">a</a></sup></th> <th>Major activities<sup id="cite_ref-ar14_1-3" class="reference"><a href="#cite_note-ar14-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </th></tr> <tr> <td>CR1</td> <td><a href="/wiki/Complement_receptor_1" title="Complement receptor 1">Complement receptor 1</a></td> <td>190,000–250,000 </td> <td>C3b, C4b, iC3b</td> <td>CD35</td> <td>B, E, FDC, Mac, M0, PMN </td> <td>Immune complex transport (E); phagocytosis (PMN, Mac); immune adhesion (E); cofactor and decay-acceleration; secondary Epstein-Barr virus receptor </td></tr> <tr> <td>CR2</td> <td><a href="/wiki/Complement_receptor_2" title="Complement receptor 2">Complement receptor 2</a></td> <td>145,000 </td> <td>C3d, iC3b, C3dg, Epstein-Barr virus</td> <td>CD21</td> <td>B, FDC </td> <td>B cell coactivator, primary Epstein-Barr virus receptor, CD23 receptor </td></tr> <tr> <td>CR3</td> <td><a href="/wiki/Macrophage-1_antigen" title="Macrophage-1 antigen">Macrophage-1 antigen</a> or "integrin α<sub>M</sub>β<sub>2</sub>"</td> <td>170,000 α chain + common 95,000 β chain </td> <td>iC3b</td> <td><a href="/wiki/CD11b" class="mw-redirect" title="CD11b">CD11b</a>+<a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a></td> <td>FDC, Mac, M0, PMN </td> <td>Leukocyte adherence, phagocytosis of iC3b-bound particles </td></tr> <tr> <td>CR4</td> <td><a href="/wiki/Integrin_alphaXbeta2" title="Integrin alphaXbeta2">Integrin alphaXbeta2</a> or "p150,95"</td> <td>150,000 α chain + common 95,000 β chain </td> <td>iC3b</td> <td><a href="/wiki/CD11c" class="mw-redirect" title="CD11c">CD11c</a>+<a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a></td> <td>D, Mac, M0, PMN </td> <td>Leukocyte adhesion </td></tr> <tr> <td>C3AR1</td> <td><a href="/wiki/C3a_receptor" title="C3a receptor">C3a receptor</a></td> <td>75,000 </td> <td>C3a</td> <td>–</td> <td>Endo, MC, Pha </td> <td>Cell activation </td></tr> <tr> <td>C5AR1</td> <td><a href="/wiki/C5a_receptor" title="C5a receptor">C5a receptor</a></td> <td>50,000 </td> <td>C5a</td> <td>CD88</td> <td>Endo, MC, Pha </td> <td>Cell activation, immune polarization, chemotaxis </td></tr> <tr> <td>C5AR2 </td> <td><a href="/wiki/C5AR2" title="C5AR2">C5a receptor 2</a> </td> <td>36,000 </td> <td>C5a </td> <td>– </td> <td> </td> <td>Chemotaxis </td></tr></tbody></table> <dl><dd>a.<style data-mw-deduplicate="TemplateStyles:r1041539562">.mw-parser-output .citation{word-wrap:break-word}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}</style><span class="citation wikicite" id="endnote_a"><b><a href="#ref_a">^</a></b></span> B: <a href="/wiki/B_cell" title="B cell">B cell</a>. E: <a href="/wiki/Erythrocyte" class="mw-redirect" title="Erythrocyte">erythrocyte</a>. Endo: <a href="/wiki/Endothelial_cell" class="mw-redirect" title="Endothelial cell">endothelial cell</a>. D: <a href="/wiki/Dendritic_cell" title="Dendritic cell">dendritic cell</a>. FDC: <a href="/wiki/Follicular_dendritic_cell" class="mw-redirect" title="Follicular dendritic cell">follicular dendritic cell</a>. Mac: <a href="/wiki/Macrophage" title="Macrophage">macrophage</a>. MC: <a href="/wiki/Mast_cell" title="Mast cell">mast cell</a>. M0: <a href="/wiki/Monocyte" title="Monocyte">monocyte</a>. Pha: <a href="/wiki/Phagocyte" title="Phagocyte">phagocyte</a>. PMN: <a href="/wiki/Polymorphonuclear_leukocyte" class="mw-redirect" title="Polymorphonuclear leukocyte">polymorphonuclear leukocyte</a>.</dd></dl> <div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Complement_receptor&action=edit&section=2" title="Edit section: Clinical significance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Main articles: <a href="/wiki/Complement_system#Role_in_disease" title="Complement system">Complement system § Role in disease</a>, <a href="/wiki/Classical_complement_pathway#Clinical_significance" title="Classical complement pathway">Classical complement pathway § Clinical significance</a>, and <a href="/wiki/Alternative_complement_pathway#Role_in_disease" title="Alternative complement pathway">Alternative complement pathway § Role in disease</a></div> <p>Deficits in complement receptor expression can cause disease.<sup id="cite_ref-eMedicine_Dermatology_6-0" class="reference"><a href="#cite_note-eMedicine_Dermatology-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Mutations in complement receptors which alter receptor function can also increase risk of certain diseases.<sup id="cite_ref-ar14_1-4" class="reference"><a href="#cite_note-ar14-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Complement_receptor&action=edit&section=3" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Complement_system" title="Complement system">Complement system</a></li> <li><a href="/wiki/Humoral_immunity" title="Humoral immunity">Humoral immunity</a></li> <li><a href="/wiki/Immune_system" title="Immune system">Immune system</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Complement_receptor&action=edit&section=4" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-ar14-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-ar14_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-ar14_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-ar14_1-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-ar14_1-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-ar14_1-4"><sup><i><b>e</b></i></sup></a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFHolers2014" class="citation journal cs1">Holers VM (29 January 2014). <a rel="nofollow" class="external text" href="https://doi.org/10.1146%2Fannurev-immunol-032713-120154">"Complement and its receptors: new insights into human disease"</a>. <i>Annual Review of Immunology</i>. <b>32</b>: 433–59. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1146%2Fannurev-immunol-032713-120154">10.1146/annurev-immunol-032713-120154</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24499275">24499275</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Annual+Review+of+Immunology&rft.atitle=Complement+and+its+receptors%3A+new+insights+into+human+disease&rft.volume=32&rft.pages=433-59&rft.date=2014-01-29&rft_id=info%3Adoi%2F10.1146%2Fannurev-immunol-032713-120154&rft_id=info%3Apmid%2F24499275&rft.aulast=Holers&rft.aufirst=VM&rft_id=https%3A%2F%2Fdoi.org%2F10.1146%252Fannurev-immunol-032713-120154&rfr_id=info%3Asid%2Fen.wikipedia.org%3AComplement+receptor" class="Z3988"></span></span> </li> <li id="cite_note-cr17-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-cr17_2-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFVerschoorKemperKöhl2017" class="citation journal cs1">Verschoor A, Kemper C, Köhl J (15 September 2017). "Complement Receptors". <i>eLS</i>: 1–17. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2F9780470015902.a0000512.pub3">10.1002/9780470015902.a0000512.pub3</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9780470015902" title="Special:BookSources/9780470015902"><bdi>9780470015902</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=eLS&rft.atitle=Complement+Receptors&rft.pages=1-17&rft.date=2017-09-15&rft_id=info%3Adoi%2F10.1002%2F9780470015902.a0000512.pub3&rft.isbn=9780470015902&rft.aulast=Verschoor&rft.aufirst=A&rft.au=Kemper%2C+C&rft.au=K%C3%B6hl%2C+J&rfr_id=info%3Asid%2Fen.wikipedia.org%3AComplement+receptor" class="Z3988"></span></span> </li> <li id="cite_note-pmid19388161-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid19388161_3-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCarroll2008" class="citation journal cs1">Carroll MC (December 2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018718">"Complement and humoral immunity"</a>. <i>Vaccine</i>. <b>26</b> (Suppl 8): I28-33. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.vaccine.2008.11.022">10.1016/j.vaccine.2008.11.022</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018718">4018718</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19388161">19388161</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Complement+and+humoral+immunity&rft.volume=26&rft.issue=Suppl+8&rft.pages=I28-33&rft.date=2008-12&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4018718%23id-name%3DPMC&rft_id=info%3Apmid%2F19388161&rft_id=info%3Adoi%2F10.1016%2Fj.vaccine.2008.11.022&rft.aulast=Carroll&rft.aufirst=MC&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4018718&rfr_id=info%3Asid%2Fen.wikipedia.org%3AComplement+receptor" class="Z3988"></span></span> </li> <li id="cite_note-Janeway_2001-4"><span class="mw-cite-backlink">^ <a href="#cite_ref-Janeway_2001_4-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Janeway_2001_4-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Janeway_2001_4-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFJaneway_JrTraversWalportShlomchik2001" class="citation book cs1">Janeway Jr CA, Travers P, Walport M, Shlomchik MJ (2001). "The complement system and innate immunity". <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/books/NBK27100"><i>Immunobiology: The Immune System in Health and Disease</i></a> (5th ed.). New York: Garland Science<span class="reference-accessdate">. Retrieved <span class="nowrap">17 June</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=The+complement+system+and+innate+immunity&rft.btitle=Immunobiology%3A+The+Immune+System+in+Health+and+Disease&rft.place=New+York&rft.edition=5th&rft.pub=Garland+Science&rft.date=2001&rft.aulast=Janeway+Jr&rft.aufirst=CA&rft.au=Travers%2C+P&rft.au=Walport%2C+M&rft.au=Shlomchik%2C+MJ&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fbooks%2FNBK27100&rfr_id=info%3Asid%2Fen.wikipedia.org%3AComplement+receptor" class="Z3988"></span></span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-5">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFParham2005" class="citation book cs1">Parham P (2005). <i>The Immune System</i> (2nd ed.). Garland Science. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9780815340935" title="Special:BookSources/9780815340935"><bdi>9780815340935</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=The+Immune+System&rft.edition=2nd&rft.pub=Garland+Science&rft.date=2005&rft.isbn=9780815340935&rft.aulast=Parham&rft.aufirst=Peter&rfr_id=info%3Asid%2Fen.wikipedia.org%3AComplement+receptor" class="Z3988"></span></span> </li> <li id="cite_note-eMedicine_Dermatology-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-eMedicine_Dermatology_6-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSchwartzThomas" class="citation web cs1">Schwartz RA, Thomas I. <a rel="nofollow" class="external text" href="http://emedicine.medscape.com/article/1051238-overview">"Complement Receptor Deficiency: eMedicine Dermatology"</a>. <i>Medscape</i><span class="reference-accessdate">. Retrieved <span class="nowrap">7 December</span> 2010</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Medscape&rft.atitle=Complement+Receptor+Deficiency%3A+eMedicine+Dermatology&rft.aulast=Schwartz&rft.aufirst=RA&rft.au=Thomas%2C+I&rft_id=http%3A%2F%2Femedicine.medscape.com%2Farticle%2F1051238-overview&rfr_id=info%3Asid%2Fen.wikipedia.org%3AComplement+receptor" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Complement_receptor&action=edit&section=5" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=Complement+receptors">Complement+receptors</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist .mw-empty-li{display:none}.mw-parser-output .hlist dt::after{content:": "}.mw-parser-output .hlist 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.mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Complement_system" title="Template:Complement system"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Complement_system" title="Template talk:Complement system"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Complement_system" title="Special:EditPage/Template:Complement system"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Complement_system" style="font-size:114%;margin:0 4em"><a href="/wiki/Complement_system" title="Complement system">Complement system</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Pathways</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Classical_complement_pathway" title="Classical complement pathway">C</a></li> <li><a href="/wiki/Lectin_pathway" title="Lectin pathway">L</a></li> <li><a href="/wiki/Alternative_complement_pathway" title="Alternative complement pathway">A</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Activators/enzymes</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Early</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>C:</i> <a href="/wiki/C1_complex" title="C1 complex">C1</a> <ul><li><a href="/wiki/Complement_component_1q" title="Complement component 1q">C1q</a></li> <li><a href="/wiki/Complement_component_1r" title="Complement component 1r">C1r</a></li> <li><a href="/wiki/Complement_component_1s" title="Complement component 1s">C1s</a></li></ul></li> <li><a href="/wiki/Complement_component_4" title="Complement component 4">C4</a> <ul><li><a href="/wiki/C4A" title="C4A">C4a</a></li> <li><a href="/wiki/C4B" class="mw-redirect" title="C4B">C4b</a></li></ul></li> <li><a href="/wiki/Complement_component_2" title="Complement component 2">C2</a></li></ul> <ul><li><i>L:</i> <a href="/wiki/MASP1_(protein)" title="MASP1 (protein)">MASP1</a>/<a href="/wiki/MASP2_(protein)" title="MASP2 (protein)">MASP2</a></li> <li><a href="/wiki/Mannan-binding_lectin" title="Mannan-binding lectin">MBL</a></li></ul> <ul><li><i>A:</i> <a href="/wiki/Complement_factor_B" title="Complement factor B">Factor B</a></li> <li><a href="/wiki/Factor_D" title="Factor D">Factor D</a></li> <li><a href="/wiki/Properdin" title="Properdin">Factor P/Properdin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Middle</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Complement_component_3" title="Complement component 3">C3</a> <ul><li><a href="/wiki/C3a_(complement)" title="C3a (complement)">C3a</a></li> <li><a href="/wiki/C3b" title="C3b">C3b</a>/<a href="/wiki/IC3b" title="IC3b">iC3b</a></li></ul></li> <li><a href="/wiki/Complement_component_5" title="Complement component 5">C5</a> <ul><li><a href="/wiki/Complement_component_5a" title="Complement component 5a">C5a</a></li> <li><a href="/wiki/Complement_component_5b" class="mw-redirect" title="Complement component 5b">C5b</a></li></ul></li></ul> <ul><li><a href="/wiki/C3-convertase" title="C3-convertase">C3-convertase</a></li> <li><a href="/wiki/C5-convertase" title="C5-convertase">C5-convertase</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Late</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Complement_membrane_attack_complex" title="Complement membrane attack complex">MAC</a> <ul><li><a href="/wiki/Complement_component_5b" class="mw-redirect" title="Complement component 5b">C5b</a></li> <li><a href="/wiki/Complement_component_6" title="Complement component 6">C6</a></li> <li><a href="/wiki/Complement_component_7" title="Complement component 7">C7</a></li> <li><a href="/wiki/C8_complex" title="C8 complex">C8</a></li> <li><a href="/wiki/Complement_component_9" title="Complement component 9">C9</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Inhibitors</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>CLA:</i> <a href="/wiki/C1-inhibitor" title="C1-inhibitor">C1-inhibitor</a></li> <li><a href="/wiki/Decay-accelerating_factor" title="Decay-accelerating factor">Decay-accelerating factor</a>/<a href="/wiki/CD59" title="CD59">CD59</a></li> <li><a href="/wiki/Complement_factor_I" title="Complement factor I">Factor I</a></li></ul> <ul><li><i>CL:</i> <a href="/wiki/C4b-binding_protein" title="C4b-binding protein">C4BP</a></li></ul> <ul><li><i>A:</i> <a href="/wiki/Factor_H" title="Factor H">Factor H</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a class="mw-selflink selflink">Complement receptors</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Complement_receptor_1" title="Complement receptor 1">CR1</a></li> <li><a href="/wiki/Complement_receptor_2" title="Complement receptor 2">CR2</a></li> <li><a href="/wiki/Macrophage-1_antigen" title="Macrophage-1 antigen">CR3</a></li> <li><a href="/wiki/Integrin_alphaXbeta2" title="Integrin alphaXbeta2">CR4</a></li> <li><a href="/wiki/Integrin_alpha_M" title="Integrin alpha M">CD11b</a>/<a href="/wiki/CD11c" class="mw-redirect" title="CD11c">CD11c</a>/<a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a></li> <li><a href="/wiki/Anaphylatoxin_receptors" title="Anaphylatoxin receptors">Anaphylatoxin</a> <ul><li><a href="/wiki/C3a_receptor" title="C3a receptor">C3a</a></li> <li><a href="/wiki/C5a_receptor" title="C5a receptor">C5a</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Function</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cytotoxicity" title="Cytotoxicity">Cytotoxicity</a>(by MAC)</li> <li><a href="/wiki/Immune_adherence" title="Immune adherence">immune adherence</a></li> <li>Inducing <a href="/wiki/Inflammation" title="Inflammation">inflammation</a></li> <li><a href="/wiki/Opsonization" class="mw-redirect" title="Opsonization">Opsonization</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Innate_immune_system:_Pattern_recognition_receptors" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Pattern_recognition_receptors" title="Template:Pattern recognition receptors"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Pattern_recognition_receptors" title="Template talk:Pattern recognition receptors"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Pattern_recognition_receptors" title="Special:EditPage/Template:Pattern recognition receptors"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Innate_immune_system:_Pattern_recognition_receptors" style="font-size:114%;margin:0 4em"><a href="/wiki/Innate_immune_system" title="Innate immune system">Innate immune system</a>: <a href="/wiki/Pattern_recognition_receptor" title="Pattern recognition receptor">Pattern recognition receptors</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Pattern_recognition_receptor#Membrane-bound_PRRs" title="Pattern recognition receptor">Membrane-bound_PRRs</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Toll-like_receptor" title="Toll-like receptor">Toll-like receptor</a></li> <li><a href="/wiki/Mannose_receptor" title="Mannose receptor">Mannose receptor</a></li> <li><a href="/wiki/Formyl_peptide_receptor" title="Formyl peptide receptor">Formyl peptide receptor</a></li> <li><a href="/wiki/Scavenger_receptor_(immunology)" title="Scavenger receptor (immunology)">Scavenger receptor</a></li> <li><a class="mw-selflink selflink">Complement receptor</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Pattern_recognition_receptor#Cytoplasmic_PRRs" title="Pattern recognition receptor">Cytoplasmic_PRRs</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/NOD-like_receptor" title="NOD-like receptor">NOD-like receptor</a></li> <li><a href="/wiki/RIG-I-like_receptor" title="RIG-I-like receptor">RIG-I-like receptor</a> <ul><li><a href="/wiki/RIG-I" title="RIG-I">RIG-I</a></li> <li><a href="/wiki/MDA5" title="MDA5">MDA5</a></li> <li><a href="/wiki/LGP2" title="LGP2">LGP2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Pattern_recognition_receptor#Secreted_PRRs" title="Pattern recognition receptor">Secreted_PRRs</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Collectin" title="Collectin">Collectin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other/ungrouped</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Immunophilins" title="Immunophilins">Immunophilins</a> (<a href="/wiki/Cyclophilin" title="Cyclophilin">Cyclophilin</a>)</li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Complement_receptor&oldid=1211921936">https://en.wikipedia.org/w/index.php?title=Complement_receptor&oldid=1211921936</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" 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