Inxight Drugs

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NCATS Inxight incorporates and unifies a wealth of data, including marketing and regulatory status, rigorous drug ingredient definitions, biological activity, clinical use and more." /> <meta name="twitter:description" value="The National Center for Advancing Translational Sciences has developed Inxight Drugs — a comprehensive portal for drug development information.NCATS Inxight incorporates and unifies a wealth of data, including marketing and regulatory status, rigorous drug ingredient definitions, biological activity, clinical use and more." /> <meta property="og:image" content='https://drugs.ncats.io/assets/ginas/images/inxight_main.jpg?w=500' /> <meta name="twitter:image" content='https://drugs.ncats.io/assets/ginas/images/inxight_main.jpg?w=500' /> <meta name="twitter:label1" value="US Approved Drugs" /> <meta name="twitter:data1" value="2447" /> <meta name="twitter:label2" value="Total Substances" /> <meta name="twitter:data2" value="156829" />   <title>Inxight Drugs</title> <link rel="icon" type="img/ico" href='/assets/ginas/images/ncats_favicon.ico'> <link rel="stylesheet" href='/webjars/bootstrap/3.3.7/css/bootstrap.min.css'> <link rel="stylesheet" href='/webjars/font-awesome/4.5.0/css/font-awesome.min.css'> <link rel="stylesheet" href='/assets/ginas/css/ng-tags-input.css'> <link rel="stylesheet" href='/assets/ginas/css/ng-tags-input.bootstrap.css'> <link rel="stylesheet" href='/assets/ginas/css/json-formatter.css'> <link rel="stylesheet" href='/assets/ginas/css/ginas.css'> <link rel="stylesheet" href='/assets/ginas/css/drugs.css'> <link rel="stylesheet" href="https://unpkg.com/flickity@2/dist/flickity.min.css"> <script src='/webjars/jquery/1.11.1/jquery.min.js'></script> <script src='/webjars/momentjs/2.11.0/moment.js'></script> <script src='/webjars/later/1.2.0/later.min.js'></script> <script src='/webjars/prettycron/0.10.0/prettycron.js'></script> <script src='/webjars/humanize-duration/3.0.0/humanize-duration.js'></script> <script src='/webjars/bootstrap/3.3.7/js/bootstrap.min.js'></script> <script src='/webjars/angularjs/1.5.7/angular.js'></script> <script src='/webjars/angular-ui-bootstrap/1.3.3/ui-bootstrap-tpls.js'></script> <script src='/webjars/angularjs/1.5.7/angular-messages.js'></script> <script src='/webjars/angularjs/1.5.7/angular-route.js'></script> <script src='/webjars/angularjs/1.5.7/angular-resource.js'></script> <script src='/webjars/angularjs/1.5.7/angular-aria.js'></script> <script src='/webjars/lodash/4.0.0/lodash.js'></script> <script src='/assets/ginas/js/angular-local-storage.js' type='text/javascript'></script> <script src='/assets/ginas/js/ginasApp.js' type='text/javascript'></script> <script src='/assets/ginas/js/ginas-admin.js' type='text/javascript'></script> <script src='/assets/ginas/js/ginas-downloads.js' type='text/javascript'></script> <script src='/assets/ginas/js/ginas-scheduled.js' type='text/javascript'></script> <script src='/assets/ginas/js/ginas-filter.js' type='text/javascript'></script> <script src='/assets/ginas/js/ginas-forms.js' type='text/javascript'></script> <script src='/assets/ginas/js/ginas-form-elements.js' type='text/javascript'></script> <script src='/assets/ginas/js/ginas-filter.js' type='text/javascript'></script> <script src='/assets/ginas/js/angular-bootstrap-file-field.js' type='text/javascript'></script> <script src='/assets/ginas/js/showErrors.js' type='text/javascript'></script> <script src='/assets/ginas/js/diff_match_patch.js' type='text/javascript'></script> <script src='/assets/ginas/js/angular-diff-match-patch.js' type='text/javascript'></script> <script src='/assets/ginas/js/angular-loading-spinner.js' type='text/javascript'></script> <script src='/assets/ginas/js/filter-listener-service.js' type='text/javascript'></script> <script src='/assets/ginas/js/validators.js' type='text/javascript'></script> <script src='/assets/ginas/js/json-formatter.js' type='text/javascript'></script> <script src='/assets/ginas/js/ng-tags-input.js' type='text/javascript'></script> <script src='/assets/ginas/js/screengrabber.js' type='text/javascript'></script> <script src='/assets/ginas/js/filereader.js' type='text/javascript'></script> <script src="https://code.highcharts.com/5.0.14/highcharts.js"></script> <script src="https://code.highcharts.com/5.0.14/modules/exporting.js"></script> <script src='https://unpkg.com/flickity@2/dist/flickity.pkgd.min.js'></script> <script type="text/javascript"> var session = { username:null }; 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showcloseHMenu=!showcloseHMenu" ng-class="(!showcloseHMenu)?'':'hidden-sm hidden-xs'"> <i class="fa fa-search" aria-hidden="true"></i> </a> </li> <li class="hidden-xl hidden-lg hidden-md"> <a class="close-loupe" ng-class="(showcloseHMenu)?'':'hidden-sm hidden-xs'" ng-click="showcloseHMenu=!showcloseHMenu; showsearchHMenu=!showsearchHMenu"> <i class="fa fa-times-circle" aria-hidden="true"></i> </a> </li> </ul> </div> </div> </nav> </div> <div class="container" id="content" > <div class="card-generic" id="whole-page-container"> <div style="height:35px;"> </div> <div class="row width95"> <div class="col-md-12 collapsible"> <div class="section-bar">Publications</div> </div> <div class="col-md-12 content" > <div class="text-block main-text-block"> <div class="paper-header"> NCATS Inxight Drugs: a comprehensive and curated portal for translational research </div> <div class="paper-authors"> Vishal B. Siramshetty, Ivan Grishagin, Ðắc-Trung Nguyễn, Tyler Peryea, Yulia Skovpen, Oleg Stroganov, Daniel Katzel, Timothy Sheils, Ajit Jadhav, Ewy A Mathé, Noel T. Southall </div> <div class="paper-journal"> <i>Nucleic Acids Research</i> <b>2022</b>, 50(D1), D1307-D1316, </div> DOI: <a target="_blank" href="https://doi.org/10.1093/nar/gkab918"> 10.1093/nar/gkab918 </a> </div> </div> <div class="col-md-12 collapsible"> <div class="section-bar">Sources</div> </div>  <div class="col-md-12 content" > <div class="text-block main-text-block"> <dl> <dt> v. 2024-03-20 (current) </dt> <dd> <ul class="list-unstyled about-list"> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">61100</span> </div> <div> <div class="source-label">Manually curated substances </div> <div class="source-version-info">Version: FRDB, October 2021</div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">156829</span> </div> <div> <div class="source-label">Substances from the <a target='_blank' href='https://gsrs.ncats.nih.gov/' title='Global Substance Registration System'> Global Substance Registration System <i class="fa fa-external-link"></i> </a> </div> <div class="source-version-info">Version: G-SRS, December 2023</div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">14814</span> </div> <div> <div class="source-label">Approved and investigational drugs from the <a target='_blank' href='https://www.sciencedirect.com/science/article/pii/S1359644619303794#bib0060' title='NCATS Pharmaceutical Collection'> NCATS Pharmaceutical Collection <i class="fa fa-external-link"></i> </a> </div> <div class="source-version-info">Version: NCATS Pharmaceutical Collection, April 2012</div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">13580</span> </div> <div> <div class="source-label">Drug ingredients from <a target='_blank' href='https://www.drugbank.ca/' title='DrugBank'> DrugBank <i class="fa fa-external-link"></i> </a> </div> <div class="source-version-info">Version: DrugBank, July 2020</div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">11833</span> </div> <div> <div class="source-label">Drug products from <a target='_blank' href='https://dailymed.nlm.nih.gov/' title='DailyMed'> DailyMed <i class="fa fa-external-link"></i> </a> </div> <div class="source-version-info">Version: DailyMed Rx, March 2024</div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">3718</span> </div> <div> <div class="source-label"> Drug substances from <a target='_blank' href='https://www.fda.gov/Drugs/InformationOnDrugs/ucm135821.htm' title='Drugs@FDA' style="display: inline-block;"> Drugs@FDA <i class="fa fa-external-link"></i> </a> & <a target='_blank' href='https://www.accessdata.fda.gov/scripts/cder/ob/' title='Orange Book'> Orange Book <i class="fa fa-external-link"></i> </a> </div> <div class="source-version-info">Version: Drugs@FDA & OB, March 2024</div> </div> </div> </li> </ul> </dd> </dl> <button ng-click="showEarlierVersions=!showEarlierVersions" class="btn btn-url font-monospace" ng-hide="showEarlierVersions"> <span>Show earlier versions <i class="fa fa-plus" aria-hidden="true"></i> </span> </button> <button ng-click="showEarlierVersions=!showEarlierVersions" class="btn btn-url font-monospace bottom-padded" ng-show="showEarlierVersions"> <span>Hide earlier versions <i class="fa fa-minus" aria-hidden="true"></i> </span> </button> <div ng-init="showEarlierVersions=false" ng-show="showEarlierVersions"> <dl> <dt> v. 2023-08-04 </dt> <dd> <ul class="list-unstyled about-list"> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">58713</span> </div> <div> <div class="source-label">Manually curated substances </div> <div class="source-version-info">Version: FRDB, October 2021</div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">150488</span> </div> <div> <div class="source-label">Substances from the <a target='_blank' href='https://gsrs.ncats.nih.gov/' title='Global Substance Registration System'> Global Substance Registration System <i class="fa fa-external-link"></i> </a> </div> <div class="source-version-info">Version: G-SRS, July 2023</div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">14814</span> </div> <div> <div class="source-label">Approved and investigational drugs from the <a target='_blank' href='https://www.sciencedirect.com/science/article/pii/S1359644619303794#bib0060' title='NCATS Pharmaceutical Collection'> NCATS Pharmaceutical Collection <i class="fa fa-external-link"></i> </a> </div> <div class="source-version-info">Version: NCATS Pharmaceutical Collection, April 2012</div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">13580</span> </div> <div> <div class="source-label">Drug ingredients from <a target='_blank' href='https://www.drugbank.ca/' title='DrugBank'> DrugBank <i class="fa fa-external-link"></i> </a> </div> <div class="source-version-info">Version: DrugBank, July 2020</div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">10769</span> </div> <div> <div class="source-label">Drug products from <a target='_blank' href='https://dailymed.nlm.nih.gov/' title='DailyMed'> DailyMed <i class="fa fa-external-link"></i> </a> </div> <div class="source-version-info">Version: DailyMed Rx, December 2021</div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">3907</span> </div> <div> <div class="source-label"> Drug substances from <a target='_blank' href='https://www.fda.gov/Drugs/InformationOnDrugs/ucm135821.htm' title='Drugs@FDA' style="display: inline-block;"> Drugs@FDA <i class="fa fa-external-link"></i> </a> & <a target='_blank' href='https://www.accessdata.fda.gov/scripts/cder/ob/' title='Orange Book'> Orange Book <i class="fa fa-external-link"></i> </a> </div> <div class="source-version-info">Version: Drugs@FDA & OB, January 2022</div> </div> </div> </li> </ul> </dd> </dl> <dl> <dt> v. 2021-07-30 </dt> <dd> <ul class="list-unstyled about-list"> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">25445</span> </div> <div> <div class="source-label">Manually curated substances </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">125036</span> </div> <div> <div class="source-label">Substances from the <a target='_blank' href='https://gsrs.ncats.nih.gov/' title='Global Substance Registration System'> Global Substance Registration System <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">14814</span> </div> <div> <div class="source-label">Approved and investigational drugs from the <a target='_blank' href='https://www.sciencedirect.com/science/article/pii/S1359644619303794#bib0060' title='NCATS Pharmaceutical Collection'> NCATS Pharmaceutical Collection <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">13580</span> </div> <div> <div class="source-label">Drug ingredients from <a target='_blank' href='https://www.drugbank.ca/' title='DrugBank'> DrugBank <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">110484</span> </div> <div> <div class="source-label">Drug products from <a target='_blank' href='https://dailymed.nlm.nih.gov/' title='DailyMed'> DailyMed <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">3847</span> </div> <div> <div class="source-label"> Drug substances from <a target='_blank' href='https://www.fda.gov/Drugs/InformationOnDrugs/ucm135821.htm' title='Drugs@FDA' style="display: inline-block;"> Drugs@FDA <i class="fa fa-external-link"></i> </a> & <a target='_blank' href='https://www.accessdata.fda.gov/scripts/cder/ob/' title='Orange Book'> Orange Book <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> </ul> </dd> </dl> <dl> <dt> v. 2019-03-15 </dt> <dd> <ul class="list-unstyled about-list"> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">13183</span> </div> <div> <div class="source-label">Manually curated substances </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">100264</span> </div> <div> <div class="source-label">Substances from the <a target='_blank' href='https://gsrs.ncats.nih.gov/' title='Global Substance Registration System'> Global Substance Registration System <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">14814</span> </div> <div> <div class="source-label">Approved and investigational drugs from the <a target='_blank' href='https://www.sciencedirect.com/science/article/pii/S1359644619303794#bib0060' title='NCATS Pharmaceutical Collection'> NCATS Pharmaceutical Collection <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">11922</span> </div> <div> <div class="source-label">Drug ingredients from <a target='_blank' href='https://www.drugbank.ca/' title='DrugBank'> DrugBank <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">167689</span> </div> <div> <div class="source-label">Drug products from <a target='_blank' href='https://dailymed.nlm.nih.gov/' title='DailyMed'> DailyMed <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">2326</span> </div> <div> <div class="source-label"> Drug substances from <a target='_blank' href='https://www.fda.gov/Drugs/InformationOnDrugs/ucm135821.htm' title='Drugs@FDA' style="display: inline-block;"> Drugs@FDA <i class="fa fa-external-link"></i> </a> & <a target='_blank' href='https://www.accessdata.fda.gov/scripts/cder/ob/' title='Orange Book'> Orange Book <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> </ul> </dd> </dl> <dl> <dt> v. 2018-08-28 </dt> <dd> <ul class="list-unstyled about-list"> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">9221</span> </div> <div> <div class="source-label">Manually curated substances </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">100169</span> </div> <div> <div class="source-label">Substances from the <a target='_blank' href='https://gsrs.ncats.nih.gov/' title='Global Substance Registration System'> Global Substance Registration System <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">14814</span> </div> <div> <div class="source-label">Approved and investigational drugs from the <a target='_blank' href='https://www.sciencedirect.com/science/article/pii/S1359644619303794#bib0060' title='NCATS Pharmaceutical Collection'> NCATS Pharmaceutical Collection <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">11292</span> </div> <div> <div class="source-label">Drug ingredients from <a target='_blank' href='https://www.drugbank.ca/' title='DrugBank'> DrugBank <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">165710</span> </div> <div> <div class="source-label">Drug products from <a target='_blank' href='https://dailymed.nlm.nih.gov/' title='DailyMed'> DailyMed <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">1899</span> </div> <div> <div class="source-label"> Drug substances from <a target='_blank' href='https://www.fda.gov/Drugs/InformationOnDrugs/ucm135821.htm' title='Drugs@FDA' style="display: inline-block;"> Drugs@FDA <i class="fa fa-external-link"></i> </a> & <a target='_blank' href='https://www.accessdata.fda.gov/scripts/cder/ob/' title='Orange Book'> Orange Book <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> </ul> </dd> </dl> <dl> <dt> v. 2018-03-09 </dt> <dd> <ul class="list-unstyled about-list"> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">9127</span> </div> <div> <div class="source-label">Manually curated substances </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">101874</span> </div> <div> <div class="source-label">Substances from the <a target='_blank' href='https://gsrs.ncats.nih.gov/' title='Global Substance Registration System'> Global Substance Registration System <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">14814</span> </div> <div> <div class="source-label">Approved and investigational drugs from the <a target='_blank' href='https://www.sciencedirect.com/science/article/pii/S1359644619303794#bib0060' title='NCATS Pharmaceutical Collection'> NCATS Pharmaceutical Collection <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">11292</span> </div> <div> <div class="source-label">Drug ingredients from <a target='_blank' href='https://www.drugbank.ca/' title='DrugBank'> DrugBank <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">165710</span> </div> <div> <div class="source-label">Drug products from <a target='_blank' href='https://dailymed.nlm.nih.gov/' title='DailyMed'> DailyMed <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">1841</span> </div> <div> <div class="source-label"> Drug substances from <a target='_blank' href='https://www.fda.gov/Drugs/InformationOnDrugs/ucm135821.htm' title='Drugs@FDA' style="display: inline-block;"> Drugs@FDA <i class="fa fa-external-link"></i> </a> & <a target='_blank' href='https://www.accessdata.fda.gov/scripts/cder/ob/' title='Orange Book'> Orange Book <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> </ul> </dd> </dl> <dl> <dt> v. 2018-02-01 </dt> <dd> <ul class="list-unstyled about-list"> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">8691</span> </div> <div> <div class="source-label">Manually curated substances </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">99827</span> </div> <div> <div class="source-label">Substances from the <a target='_blank' href='https://gsrs.ncats.nih.gov/' title='Global Substance Registration System'> Global Substance Registration System <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">14814</span> </div> <div> <div class="source-label">Approved and investigational drugs from the <a target='_blank' href='https://www.sciencedirect.com/science/article/pii/S1359644619303794#bib0060' title='NCATS Pharmaceutical Collection'> NCATS Pharmaceutical Collection <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">10500</span> </div> <div> <div class="source-label">Drug ingredients from <a target='_blank' href='https://www.drugbank.ca/' title='DrugBank'> DrugBank <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">66870</span> </div> <div> <div class="source-label">Drug products from <a target='_blank' href='https://dailymed.nlm.nih.gov/' title='DailyMed'> DailyMed <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> </ul> </dd> </dl> <dl> <dt> v. 2017-10-11 </dt> <dd> <ul class="list-unstyled about-list"> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">6684</span> </div> <div> <div class="source-label">Manually curated substances </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">99393</span> </div> <div> <div class="source-label">Substances from the <a target='_blank' href='https://gsrs.ncats.nih.gov/' title='Global Substance Registration System'> Global Substance Registration System <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">14814</span> </div> <div> <div class="source-label">Approved and investigational drugs from the <a target='_blank' href='https://www.sciencedirect.com/science/article/pii/S1359644619303794#bib0060' title='NCATS Pharmaceutical Collection'> NCATS Pharmaceutical Collection <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">7039</span> </div> <div> <div class="source-label">Drug ingredients from <a target='_blank' href='https://www.drugbank.ca/' title='DrugBank'> DrugBank <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> <li> <div class="source-row"> <div class="badge-wrap-sources badge-sources-start"> <span class="badge purple">66870</span> </div> <div> <div class="source-label">Drug products from <a target='_blank' href='https://dailymed.nlm.nih.gov/' title='DailyMed'> DailyMed <i class="fa fa-external-link"></i> </a> </div> </div> </div> </li> </ul> </dd> </dl> </div> </div> </div> </div> <div class="row width95"> <div class="col-md-12 collapsible"> <div class="section-bar">Data Subsets</div> </div> <div class="col-md-12 content" > <div class="text-block main-text-block"> <dl class="nostyle-padded"> <dt> <a target="_self" href="/drugs" class="counts"> US Approved Drugs </a> </dt> <dd> A list of drugs that have been approved by the FDA for marketing in the US according to one or more of the following sources: <ul class="nomargin"> <li>DailyMed</li> <li>Drugs@FDA</li> <li>OrangeBook</li> <li>Code of Federal Regulations Title 21 – Over-the-Counter Drugs</li> </ul> </dd> <dt> <a target="_self" href="/marketeds" class="counts"> Marketed Drugs </a> </dt> <dd> Substances that have a record of ever having been approved for marketing anywhere in the world according to any of the sources used in NCATS Inxight. </dd> <dt> <a target="_self" href="/clinicals" class="counts"> Investigational Drugs </a> </dt> <dd> Substances that have ever entered any clinical trial regardless of the outcome, but have not been approved or marketed. </dd> <dt> <a target="_self" href="/substances" class="counts"> All Substances </a> </dt> <dd> All substances in the database. </dd> </dl> </div> </div> </div> <div class="row width95"> <div class="col-md-12 collapsible"> <div class="section-bar">Definitions</div> </div> <div class="col-md-12 content" > <div class="text-block main-text-block"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title"> Drug (therapeutic, intervention) </h3> </div> <div class="panel-body additional-data"> The "platonic", idealized form of an active pharmaceutical ingredient included in or produced by a currently or previously marketed drug product to contribute to the pharmacological action used to treat a condition. Usually an active moiety, except for prodrugs. </div> </div> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title"> Active Pharmaceutical Ingredient </h3> </div> <div class="panel-body additional-data"> A substance present in a currently or previously marketed drug product that is or becomes pharmacologically active once delivered to patients. </div> </div> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title"> Prodrug </h3> </div> <div class="panel-body additional-data"> A substance that is not pharmacologically active until covalently modified by endogenous biological activity. </div> </div> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title"> Active Moiety </h3> </div> <div class="panel-body additional-data"> <p> The essential aspect of a substance responsible for its pharmacological activity. </p> <p> 21 CFR 314.108(a): <blockquote id="about-blockquote"> The molecule or ion, excluding those appended portions of the molecule that cause the drug to be an ester, salt (including a salt with hydrogen or coordination bonds), or other noncovalent derivative (such as a complex, chelate, or clathrate) of the molecule, responsible for the physiological or pharmacological action of the drug substance. </blockquote> </p> </div> </div> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title"> Drug Product </h3> </div> <div class="panel-body additional-data"> A regulated, packaged, and formulated product currently or previously marketed for medical use containing one or more active pharmaceutical ingredients. </div> </div> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title"> Substance </h3> </div> <div class="panel-body additional-data"> <p> Fundamentally, an ingredient in a drug product. Substances are catalogued by the Federal Drug Administration (FDA) and assigned a UNique Ingredient Identifier (<a target='_blank' href='https://www.fda.gov/forindustry/datastandards/substanceregistrationsystem-uniqueingredientidentifierunii/' title='UNII'>UNII</a>). Multiple substances can share the same active moiety. Currently, there are six distinct types of Substances, as defined by the ISO 11238 identification of medical products standard: chemical, protein, nucleic acid, polymer, structurally diverse, and mixture. In addition, FDA defines a "concept" as a collection of names, codes, and relationships, which refer to matter that does not fit the definition of a substance, but is still of research, regulatory, or clinical significance. To ensure comprehensive coverage and avoid ambiguity, NCATS Inxight Drugs includes concepts into its list of Substances. </p> <p> ISO 11238: <blockquote id="about-blockquote"> Any matter that has discrete existence, whose origin may be biological, mineral or chemical. Substances can be either single substances or mixture substances. Single substances shall be defined using a minimally sufficient set of data elements divided into five types, chemical, protein, nucleic acid, polymer, and structurally diverse. Substances may be salts, solvates, free acids, free bases, mixtures of related compounds that are either isolated or synthesized together. </blockquote> </p> </div> </div> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title"> Primary Target </h3> </div> <div class="panel-body additional-data"> A biological component, substance, or process that is modulated by a therapeutic intervention, and is suspected to be the most relevant target for the biological activity associated with the major pharmacological use or proposed indication of the therapeutic intervention. </div> </div> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title"> Treatment Modality </h3> </div> <div class="panel-body additional-data"> Substances are classified based on their effect on disease progression for a specific disease or condition. <br> NCATS Inxight uses the following categories: <dl class="nostyle-padded"> <dt>Primary</dt> <dd> Halts or slows disease progression. Treatment often targets the primary pathology of a disease. </dd> <dt>Preventing</dt> <dd> Intended to prevent the development of a medical condition. </dd> <dt>Palliative</dt> <dd> Improves the quality of life by alleviating the associated symptoms, without necessarily affecting the underlying pathology. </dd> <dt>Secondary</dt> <dd> Treats adverse effects associated with the treatment of a condition. </dd> <dt>Diagnostic</dt> <dd> A substance used for diagnostic purposes, including disease detection and monitoring of disease progression. </dd> <dt>Inactive ingredient</dt> <dd> An ingredient of a given formulation (most frequently, an excipient) that does not exhibit pharmacological activity. In this case, a condition is only related to such compound via the formulation used to affect (treat or diagnose) this condition. </dd> </dl> </div> </div> </div> </div> </div> <div class="row width95"> <div class="col-md-12 collapsible"> <div class="section-bar">NCATS Inxight Team</div> </div> <div class="col-md-12 content" > <div class="text-block main-text-block"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title"> Current </h3> </div> <div class="panel-body additional-data"> <dl class="nostyle-padded dl-horizontal"> <dt> <a href="https://ncats.nih.gov/staff/mathee" target="_blank"> Ewy A. Mathé </a> </dt> <dd> NCATS/NIH, Division of Preclinical Innovation, IFX Core </dd> <dt> <a href="https://ncats.nih.gov/preclinical/core/informatics/informatics-scientists-software-developers" target="_blank"> Keith Kelleher </a> </dt> <dd> NCATS/NIH, Division of Preclinical Innovation, IFX Core </dd> </dl> </div> <div class="panel-heading"> <h3 class="panel-title"> Former </h3> </div> <div class="panel-body additional-data"> <dl class="nostyle-padded dl-horizontal"> <dt> <a href="https://www.linkedin.com/in/ajitjadhavusa/" target="_blank"> Ajit Jadhav </a> </dt> <dd> Pfizer </dd> <dt> <a href="https://www.linkedin.com/in/noel-southall-826bbb6/" target="_blank"> Noel Southall </a> </dt> <dd>AstraZeneca</dd> <dt> <a href="https://orcid.org/0000-0003-2591-9948" target="_blank"> Ðắc-Trung Nguyễn </a> </dt> <dd>Pfizer</dd> <dt> <a href="https://www.linkedin.com/in/ivan-grishagin-05570b3a" target="_blank"> Ivan Grishagin </a> </dt> <dd></dd> <dt> <a href="https://www.linkedin.com/in/tyler-peryea-40359996/" target="_blank"> Tyler Peryea </a> </dt> <dd>FDA</dd> </dl> </div> </div> </div> </div> </div> <div class="row width95"> <div class="col-md-12 collapsible"> <div class="section-bar">Release Notes</div> </div> <div class="col-md-12 content" > <div class="text-block main-text-block"> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title"> March 20, 2024 </h3> </div> <div class="panel-body additional-data"> Updates <ul> <li>Stitcher and Inxight are now built using these updated data sources: <ul> <li>G-SRS, December 2023</li> <li>Drugs - FDA & OB, March 2024</li> <li>ClinicalTrials, March 2024</li> <li>FDA Excipients, March 2024</li> <li>FDA NADA and ANADAs, March 2024</li> <li>DailyMed Rx, March 2024</li> <li>Broad Institute Drug List 2024-03-05</li> </ul> </li> </ul> </div> </div> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title"> August 4, 2023 </h3> </div> <div class="panel-body additional-data"> Updates <ul> <li>Stitcher and Inxight are now built using the G-SRS data from July 2023.</li> <li>There is a new dataset from the Fast Response Database (FRDB), available on the <a href="/downloads-public" target="_self">Downloads page</a>.</li> </ul> </div> </div> <div class="panel panel-default additional"> <div class="panel-heading"> <h3 class="panel-title"> March 15, 2023 </h3> </div> <div class="panel-body additional-data"> Updates <ul> <li>Stitcher and Inxight are now built using the G-SRS data from December 2022.</li> <li>This Release Notes section is new, and will summarize recent enhancements and fixes.</li> <li>There is a new dataset from the Fast Response Database (FRDB), available on the <a href="/downloads-public" target="_self">Downloads page</a>.</li> </ul> Fixes <ul> <li>Previously, the Sequence Search functionality was broken. The problem is fixed.</li> <li>Previously, some drug pages may render some cards incorrectly, such as with {cardTitle} instead of the card title, due to associated diseases having some problematic characters. The problem is fixed.</li> <li>Previously, the Application fields might not show up depending on the format of the data coming from Stitcher. The problem is fixed.</li> </ul> </div> </div> </div> </div> </div> <div class="row width95 margin-top-15"> Last updated: August 4, 2023 </div> </div> <mol-export></mol-export> </div> <script> $(document).ready(function(){ try{ $("table.gsrs-datatable").DataTable( { "lengthMenu": [[5, 20, 100, -1], [5, 20, 100, "All"]], language: { search: "", searchPlaceholder: "Search..." }, "aaSorting": [], "scrollX": true }); }catch(e){ console.log(e); } $('.unloaded').removeClass("unloaded"); $('body').scrollspy({ offset:300, target:".sidebar-inner" }); $('#affix').affix({ offset: { top: 50 } }); $(".dataTables_filter input").addClass("form-control"); }); var onResize = function() { // apply dynamic padding at the top of the body according to the fixed navbar height $("body").css("padding-top", $(".navbar-fixed-top").height()); }; // attach the function to the window resize event $(window).resize(onResize); // call it also when the page is ready after load or reload $(function() { onResize(); }); 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