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id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="fr" dir="ltr"><div class="bandeau-container metadata homonymie hatnote"><div class="bandeau-cell bandeau-icone" style="display:table-cell;padding-right:0.5em"><span class="noviewer" typeof="mw:File"><a href="/wiki/Aide:Homonymie" title="Aide:Homonymie"><img alt="Page d’aide sur l’homonymie" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a9/Logo_disambig.svg/20px-Logo_disambig.svg.png" decoding="async" width="20" height="15" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a9/Logo_disambig.svg/30px-Logo_disambig.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a9/Logo_disambig.svg/40px-Logo_disambig.svg.png 2x" data-file-width="512" data-file-height="375" /></a></span></div><div class="bandeau-cell" style="display:table-cell;padding-right:0.5em"> <p>Pour les articles homonymes, voir <a 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class="bandeau-cell" style="display:table-cell;padding-right:0.5em"> <p><strong class="bandeau-titre">Cet article est une <a href="/wiki/Aide:%C3%89bauche" title="Aide:Ébauche">ébauche</a> concernant l’<a href="/wiki/Anatomie" title="Anatomie">anatomie</a>, la <a href="/wiki/Biologie_cellulaire" title="Biologie cellulaire">biologie cellulaire</a> et <a href="/wiki/Biologie_mol%C3%A9culaire" title="Biologie moléculaire">moléculaire</a> et la <a href="/wiki/M%C3%A9decine" title="Médecine">médecine</a>.</strong> </p><p>Vous pouvez partager vos connaissances en l’améliorant (<b><a href="/wiki/Aide:Comment_modifier_une_page" title="Aide:Comment modifier une page">comment ?</a></b>) selon les recommandations des <a href="/wiki/Projet:Accueil" title="Projet:Accueil">projets correspondants</a>. </p> </div></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/Fichier:Normal_Epidermis_and_Dermis_with_Intradermal_Nevus_10x.JPG" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b4/Normal_Epidermis_and_Dermis_with_Intradermal_Nevus_10x.JPG/220px-Normal_Epidermis_and_Dermis_with_Intradermal_Nevus_10x.JPG" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b4/Normal_Epidermis_and_Dermis_with_Intradermal_Nevus_10x.JPG/330px-Normal_Epidermis_and_Dermis_with_Intradermal_Nevus_10x.JPG 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b4/Normal_Epidermis_and_Dermis_with_Intradermal_Nevus_10x.JPG/440px-Normal_Epidermis_and_Dermis_with_Intradermal_Nevus_10x.JPG 2x" data-file-width="2048" data-file-height="1536" /></a><figcaption>Jonction dermo-épidermique sous le <a href="/wiki/Stratum_basale" class="mw-redirect" title="Stratum basale">stratum basale</a> violet foncé.</figcaption></figure> <p>La <b>jonction dermo-épidermique</b>, appelée aussi <b>lame basale épidermique</b> ou <b>membrane basale épidermique</b>, est la région tissulaire qui sépare le <a href="/wiki/Derme" title="Derme">derme</a> de l'<a href="/wiki/%C3%89piderme_(anatomie)" title="Épiderme (anatomie)">épiderme</a>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Jonction_dermo-%C3%A9pidermique&veaction=edit&section=1" title="Modifier la section : Structure" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Jonction_dermo-%C3%A9pidermique&action=edit&section=1" title="Modifier le code source de la section : Structure"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>La <a href="/wiki/Microscope_%C3%A9lectronique" title="Microscope électronique">microscopie électronique</a> révèle trois zones distinctes dans la jonction dermo-épidermique<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite_crochet">[</span>1<span class="cite_crochet">]</span></a></sup> : </p> <ul><li>la membrane plasmique du pôle basal des cellules du <a href="/wiki/Stratum_basale" class="mw-redirect" title="Stratum basale">stratum basale</a></li> <li>la membrane basale composée de deux feuillets, la <i><span class="lang-la" lang="la">lamina lucida</span></i> (zone transparente aux électrons) et la <i><span class="lang-la" lang="la">lamina densa</span></i> (zone dense aux électrons)</li> <li>la zone fibrillaire ou <i><span class="lang-la" lang="la">sub-lamina densa</span></i></li></ul> <div class="mw-heading mw-heading2"><h2 id="Fonctions">Fonctions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Jonction_dermo-%C3%A9pidermique&veaction=edit&section=2" title="Modifier la section : Fonctions" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Jonction_dermo-%C3%A9pidermique&action=edit&section=2" title="Modifier le code source de la section : Fonctions"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>La jonction dermo-épidermique a une fonction d'adhésion entre l'épiderme et le derme, de barrière physico-chimique, de circulation orientée de nutriments et de composants du <a href="/wiki/Syst%C3%A8me_immunitaire" title="Système immunitaire">système immunitaire</a><sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite_crochet">[</span>2<span class="cite_crochet">]</span></a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Maladies">Maladies</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Jonction_dermo-%C3%A9pidermique&veaction=edit&section=3" title="Modifier la section : Maladies" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Jonction_dermo-%C3%A9pidermique&action=edit&section=3" title="Modifier le code source de la section : Maladies"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Les <a href="/wiki/Dermatose" title="Dermatose">dermatoses</a> bulleuses de nature auto-immune (<a href="/wiki/N%C3%A9crolyse_%C3%A9pidermique_toxique" class="mw-redirect" title="Nécrolyse épidermique toxique">nécrolyse épidermique toxique</a>, <a href="/wiki/Syndrome_de_Stevens-Johnson" title="Syndrome de Stevens-Johnson">syndrome de Stevens-Johnson</a>) sont liées à la présence d'<a href="/wiki/Anticorps" title="Anticorps">anticorps</a> dirigés contre les structures antigéniques des systèmes d'adhésion <a href="/wiki/K%C3%A9ratinocyte" title="Kératinocyte">interkératinocytaire</a> ou de la jonction dermo-épidermique<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite_crochet">[</span>3<span class="cite_crochet">]</span></a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Notes_et_références"><span id="Notes_et_r.C3.A9f.C3.A9rences"></span>Notes et références</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Jonction_dermo-%C3%A9pidermique&veaction=edit&section=4" title="Modifier la section : Notes et références" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Jonction_dermo-%C3%A9pidermique&action=edit&section=4" title="Modifier le code source de la section : Notes et références"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="references-small decimal" style=""><div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink noprint"><a href="#cite_ref-1">↑</a> </span><span class="reference-text"><span class="ouvrage" id="Mélissopoulos,_Christine_Levacher2012"><span class="ouvrage" id="Alexandre_Mélissopoulos,_Christine_Levacher2012">Alexandre Mélissopoulos, Christine Levacher, <cite class="italique">La peau</cite>, Lavoisier, <time>2012</time>, <abbr class="abbr" title="page">p.</abbr> 53<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=La+peau&rft.pub=Lavoisier&rft.au=Alexandre+M%C3%A9lissopoulos%2C+Christine+Levacher&rft.date=2012&rft.pages=53&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AJonction+dermo-%C3%A9pidermique"></span></span></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink noprint"><a href="#cite_ref-2">↑</a> </span><span class="reference-text"><span class="ouvrage" id="2009"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Dirk Breitkreutz, Nicolae Mirancea, Roswitha Nischt, « <cite style="font-style:normal" lang="en">Basement membranes in skin: unique matrix structures with diverse functions?</cite> », <i><span class="lang-en" lang="en">Histochemistry and Cell Biology</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 132, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 1,‎ <time class="nowrap" datetime="2009-07" data-sort-value="2009-07">juillet 2009</time>, <abbr class="abbr" title="page(s)">p.</abbr> 1-10. <small style="line-height:1em;">(<a href="/wiki/PubMed" title="PubMed">PMID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/19333614">19333614</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1007/s00418-009-0586-0">10.1007/s00418-009-0586-0</a></span>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Basement+membranes+in+skin%3A+unique+matrix+structures+with+diverse+functions%3F&rft.jtitle=Histochemistry+and+Cell+Biology&rft.issue=1&rft.date=2009-07&rft.volume=132&rft.pages=1-10.&rft_id=info%3Adoi%2F10.1007%2Fs00418-009-0586-0&rft_id=info%3Apmid%2F19333614&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AJonction+dermo-%C3%A9pidermique"></span></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink noprint"><a href="#cite_ref-3">↑</a> </span><span class="reference-text"><span class="ouvrage" id="Sève,_Laurent_Kodjikian2013"><span class="ouvrage" id="Pascal_Sève,_Laurent_Kodjikian2013">Pascal Sève, Laurent Kodjikian, <cite class="italique">Œil et Maladies systémiques</cite>, Lavoisier, <time>2013</time>, <abbr class="abbr" title="page">p.</abbr> 471<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=%C5%92il+et+Maladies+syst%C3%A9miques&rft.pub=Lavoisier&rft.au=Pascal+S%C3%A8ve%2C+Laurent+Kodjikian&rft.date=2013&rft.pages=471&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AJonction+dermo-%C3%A9pidermique"></span></span></span></span> </li> </ol></div> </div> <div class="mw-heading mw-heading2"><h2 id="Voir_aussi">Voir aussi</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Jonction_dermo-%C3%A9pidermique&veaction=edit&section=5" title="Modifier la section : Voir aussi" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Jonction_dermo-%C3%A9pidermique&action=edit&section=5" title="Modifier le code source de la section : Voir aussi"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Articles_connexes">Articles connexes</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Jonction_dermo-%C3%A9pidermique&veaction=edit&section=6" title="Modifier la section : Articles connexes" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Jonction_dermo-%C3%A9pidermique&action=edit&section=6" title="Modifier le code source de la section : Articles connexes"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/%C3%89piderme_(anatomie)" title="Épiderme (anatomie)">Épiderme</a></li> <li><a href="/wiki/Derme" title="Derme">Derme</a></li> <li><a href="/wiki/Lame_basale" title="Lame basale">Lame basale</a></li> <li><a href="/wiki/Membrane_basale" title="Membrane basale">Membrane basale</a></li></ul> <div class="mw-heading mw-heading3"><h3 id="Liens_externes">Liens externes</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Jonction_dermo-%C3%A9pidermique&veaction=edit&section=7" title="Modifier la section : Liens externes" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Jonction_dermo-%C3%A9pidermique&action=edit&section=7" title="Modifier le code source de la section : Liens externes"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="http://biologiedelapeau.fr/spip.php?article47">La jonction dermo-épidermique</a></li></ul> <div class="navbox-container" style="clear:both;"> <table class="navbox collapsible noprint autocollapse" style=""> <tbody><tr><th class="navbox-title" colspan="2" style=""><div style="float:left; width:6em; text-align:left"><div class="noprint plainlinks nowrap tnavbar" style="padding:0; font-size:xx-small; color:var(--color-emphasized, #000000);"><a href="/wiki/Mod%C3%A8le:Palette_Syst%C3%A8me_t%C3%A9gumentaire" title="Modèle:Palette Système tégumentaire"><abbr class="abbr" title="Voir ce modèle.">v</abbr></a> · <a class="external text" href="https://fr.wikipedia.org/w/index.php?title=Mod%C3%A8le:Palette_Syst%C3%A8me_t%C3%A9gumentaire&action=edit"><abbr class="abbr" title="Modifier ce modèle. Merci de prévisualiser avant de sauvegarder.">m</abbr></a></div></div><div style="font-size:110%"><a href="/wiki/Syst%C3%A8me_t%C3%A9gumentaire" title="Système tégumentaire">Système tégumentaire</a> des mammifères</div></th> </tr> <tr> <th class="navbox-group" style="">Principaux éléments</th> <td class="navbox-list" style=""><div class="liste-horizontale"> <ul><li><a href="/wiki/Peau" title="Peau">Peau</a></li> <li>Glandes <ul><li><a href="/wiki/Glande_sudoripare" title="Glande sudoripare">sudoripares</a></li> <li><a href="/wiki/Glande_s%C3%A9bac%C3%A9e" title="Glande sébacée">sébacées</a></li> <li><a href="/wiki/Glande_mammaire" title="Glande mammaire">mammaires</a></li></ul></li> <li><a href="/wiki/Phan%C3%A8re" title="Phanère">Phanères</a> <ul><li><a href="/wiki/Poil" title="Poil">poils</a></li> <li><a href="/wiki/Ongle" title="Ongle">ongles</a></li></ul></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="">Couches de la peau</th> <td class="navbox-list navbox-even" style=""><div class="liste-horizontale"> <ul><li><a href="/wiki/%C3%89piderme_(anatomie)" title="Épiderme (anatomie)">Épiderme</a> <ul><li><a href="/wiki/Stratum_corneum" title="Stratum corneum">corné</a></li> <li><a href="/wiki/Stratum_lucidum" title="Stratum lucidum">clair</a></li> <li><a href="/wiki/Stratum_granulosum" title="Stratum granulosum">granuleux</a></li> <li><a href="/wiki/Stratum_spinosum" title="Stratum spinosum">spineux</a></li> <li><a href="/wiki/Stratum_germinativum" title="Stratum germinativum">germinatif</a></li></ul></li> <li><a href="/wiki/Derme" title="Derme">Derme</a> <ul><li><a href="/wiki/Derme_papillaire" title="Derme papillaire">papillaire</a></li> <li><a href="/wiki/Derme_r%C3%A9ticulaire" title="Derme réticulaire">réticulaire</a></li> <li><a href="/wiki/Derme_profond" title="Derme profond">profond</a></li></ul></li> <li><a href="/wiki/Hypoderme_(peau)" title="Hypoderme (peau)">Hypoderme</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="">Zones de transition</th> <td class="navbox-list" style=""><div class="liste-horizontale"> <ul><li><a href="/wiki/Paupi%C3%A8re" title="Paupière">Paupières</a></li> <li><a href="/wiki/Tympan_humain" title="Tympan humain">Tympans</a></li> <li><a href="/wiki/Narine" title="Narine">Narines</a></li> <li><a href="/wiki/L%C3%A8vre" title="Lèvre">Lèvres</a></li> <li><a href="/wiki/M%C3%A9at_ur%C3%A9tral" title="Méat urétral">Méat urétral</a></li> <li><a href="/wiki/Vestibule_vulvaire" title="Vestibule vulvaire">Vestibule vulvaire</a></li> <li><a href="/wiki/Canal_anal" title="Canal anal">Canal anal</a></li></ul> </div></td> </tr> <tr> <td class="navbox-banner" style="" colspan="2">Voir aussi : <a href="/wiki/Dermatologie" title="Dermatologie">dermatologie</a></td></tr></tbody></table> </div> <ul id="bandeau-portail" class="bandeau-portail"><li><span class="bandeau-portail-element"><span class="bandeau-portail-icone"><span class="noviewer" typeof="mw:File"><a 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