Poorer antiretroviral response among HIV patients with HBV, HCV coinfection

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<a href="/web/20130820120130/http://www.healio.com/infectious-disease/hepatitis-resource-center-2013"> Hepatitis C Resource Center</a> <span>›</span> <a href="/web/20130820120130/http://www.healio.com/infectious-disease/hepatitis-resource-center-2013/poorer-antiretroviral-response-among-hiv-patients-with-hbv-hcv-coinfection"> Poorer antiretroviral response among HIV patients with HBV, HCV coinfection</a> </p>  <script language="javascript" type="text/javascript"> $(document).ready(function () { var submitbtn = $('*[id^="pd-vote-button"]'); $(submitbtn).click(function () { show_confirm(); }); }); function AjaxFailed(result) { alert(result.status + " " + result.statusText + " " + result.responseText); } function AjaxSucceeded(result) { } function show_confirm() { var selectrb = $('input[id^="PDI_answer"]:radio:checked') var answerid = $(selectrb).attr("value"); var testid = $(selectrb).attr("name"); var userid = $("#contactid").attr("value"); data = { 'userid': userid, 'testid': testid, 'answerid': answerid }; $.ajax({ type: "POST", url: "https://web.archive.org/web/20130820120130/http://www.healio.com/webservices/CaptureRecord.asmx/savePollAnswer", contentType: "application/json; charset=utf-8", dataType: "json", data: JSON.stringify(data), success: function (msg) { AjaxSucceeded(msg); }, error: function (emsg) { AjaxFailed(emsg); } }); } </script> <link href="/web/20130820120130cs_/http://www.healio.com/~/media/Images/Resource Centers/Infectious Disease/Hep C Resource Center 2013/RC_Hep C Resource Center 2013.css" rel="stylesheet" type="text/css"/> <input type="hidden" id="contactid" value="{0}"/> <div class="resource-wrap"> <a href="/web/20130820120130/http://www.healio.com/infectious-disease/hepatitis-resource-center-2013"><img src="/web/20130820120130im_/http://www.healio.com/~/media/Images/Resource Centers/Infectious Disease/Hep C Resource Center 2013/130824_HepC_ResourceCenter_Banner_488x89.jpg" alt="" border="0"/></a> <h2></h2>  <div class="content"> <h2> Poorer antiretroviral response among HIV patients with HBV, HCV coinfection</h2> <h3 class="deck"> </h3> <p class="main-subtitle"> </p> <ul class="meta-info"> <li> July 9, 2013</li> </ul> <div class="wyContent"> <p>Patients with HIV coinfected with hepatitis B or hepatitis C virus experienced poorer outcomes from antiretroviral therapy compared with monoinfected patients in a study presented at the International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention in Kuala Lumpur, Malaysia.</p> <p>Researchers evaluated data collected from the TREAT Asia HIV Observational Database on 7,455 patients with <a href="https://web.archive.org/web/20130820120130/http://www.healio.com/infectious-disease/hiv-aids" target="_blank">HIV</a> treated at 22 Asian hospitals. All participants received antiretroviral therapy (ART), with a target HIV viral load (VL) of fewer than 1,000 copies/mL. Among patients with evaluable test results, 10.45% were coinfected with HBV and 15.2% with <a href="https://web.archive.org/web/20130820120130/http://www.healio.com/infectious-disease/hepatitis-resource-center-2013" target="_blank">HCV</a>.</p> <p>After 180 days of therapy, CD4 counts were significantly lower among patients coinfected with either HBV (adjusted difference=–15.5 cells/mcL; <em>P</em><em>=</em>.011) or HCV (aDiff=–37.8 cells/mcL; <em>P</em><.001) compared with monoinfected patients after initiating ART. CD4 increases were smaller among those with HIV subtype CRF01AE compared with subtype B (–35.5 cells/mcL; <em>P</em><em>=</em>.026).</p> <p>The target VL was achieved in a median of 1.28 years within the cohort. Patients coinfected with HBV or HCV experienced a longer time to VL than monoinfected participants, but this difference was not statistically significant.</p> <p>Coinfected patients had poorer survival than monoinfected patients. Multivariate analysis indicated a significant association between mortality and HCV coinfection (adjusted HR=1.81; 95% CI, 1.2-2.71). No association was observed between HIV VL and coinfection with either HBV or HCV.</p> <p>“In this Asia regional HIV cohort, patients with HBV or HCV coinfection had significantly lower CD4 counts [and] smaller CD4 increases after 180 days of ART,” the researchers concluded. “We need to test, identify and initiate [highly active] ART early in HBV and HCV coinfected [patients] to have a better treatment effect.”</p> <p><strong>For more information:</strong></p> <p>Chen YMA. TULBPE13: HBV and HCV Coinfection: Long-term Immunological, Virological and Survival Outcomes Following cART. Presented at: <a href="https://web.archive.org/web/20130820120130/http://www.ias2013.org/" target="blank">IAS Conference on HIV Pathogenesis, Treatment and Prevention</a>; June 30-July 03, 2013; Kuala Lumpur, Malaysia.</p> </div>  <div class="fig left"> <p class="figcaption"> </p> </div> <div class="wyPagination">   </div>  <div class="follow"> <img src="/web/20130820120130im_/http://www.healio.com/~/media/Images/News/FollowUs.jpg" id="layout_0_maincontent_0_NewsArticle_SocialFollow_socialfollow" name="socialfollow" alt="Follow us" usemap="#followus" border="0"/> <map id="followus" name="followus"> <area id="layout_0_maincontent_0_NewsArticle_SocialFollow_followfb" shape="rect" coords="51,5,5,51" target="_blank" href="https://web.archive.org/web/20130820120130/https://www.facebook.com/pages/Healiocom-Hepatology/344508705629213?ref=ts&fref=ts" alt="Follow us on Facebook"></area> <area id="layout_0_maincontent_0_NewsArticle_SocialFollow_followtw" shape="rect" coords="241,3,281,50" target="_blank" href="https://web.archive.org/web/20130820120130/https://twitter.com/healiohep" alt="Follow us on Twitter"></area> </map> </div> </div>  <div class="social-links"> <div class="fb-like" data-send="false" data-width="300" data-show-faces="true" data-action="recommend"></div> <ul class="share"> <li><a href="javascript:void(0)" id="twitter" target="_new">Tweet</a></li> <li><a href="javascript:void(0)" id="facebook" target="_new">Share</a></li> <li class="linkedin"><a href="javascript:void(0)" id="linkedin">Link</a></li> <li><span class="db-wrapper"><span class="g-plusone" data-size="tall" data-annotation="none"></span></span></li> <li><a href="javascript:void(0)" id="email">Email</a></li> <li class="last"><a href="javascript:void(0)" id="print">Print</a></li> </ul> </div>  <div id="respond"> <h4> Comments</h4> <script language="javascript" type="text/javascript"> var idcomments_acct = 'aa6ff53f9870e40f92f83e1b5df3cddf'; var idcomments_post_id = '{DE075466-3AD5-420F-B45A-4D472B8DD514}'; var idcomments_post_url; </script> <span id="IDCommentsPostTitle" style="display: none"></span> <script type="text/javascript" src="https://web.archive.org/web/20130820120130js_/http://www.intensedebate.com/js/genericCommentWrapperV2.js"></script> <p class="comment-notes"> Healio is intended for health care provider use and all comments will be posted at the discretion of the editors. 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