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<HTML><HEAD><TITLE>tech20170829_nt10k.htm</TITLE>  </HEAD> <BODY style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman, Times, serif; MARGIN-LEFT: 10px; MARGIN-RIGHT: 10px">   UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549     <HR style="BORDER-TOP: medium none; HEIGHT: 2px; BORDER-RIGHT: medium none; BORDER-BOTTOM: medium none; COLOR: #000000; BORDER-LEFT: medium none; WIDTH: 100%; BACKGROUND-COLOR: #000000" align=center> FORM 12b-25   <HR style="BORDER-TOP: medium none; HEIGHT: 2px; BORDER-RIGHT: medium none; BORDER-BOTTOM: medium none; COLOR: #000000; BORDER-LEFT: medium none; WIDTH: 100%; BACKGROUND-COLOR: #000000" align=center> NOTIFICATION OF LATE FILING   <TABLE id=TBL32 style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman, Times, serif; WIDTH: 100%; TEXT-INDENT: 0px" cellSpacing=0 cellPadding=0 border=0> <TR> <TD style="VERTICAL-ALIGN: top; WIDTH: 32%"> (Check One)    </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 67%"> ☒  Form 10-K     ☐  Form 20-F     ☐  Form 11-K     ☐  Form 10-Q ☐  Form 10-D     ☐  Form N-SAR     ☐  Form N-CSR</TD></TR> <TR> <TD style="VERTICAL-ALIGN: middle; WIDTH: 32%">  </TD> <TD style="VERTICAL-ALIGN: middle; WIDTH: 1%" colSpan=2>  </TD></TR> <TR> <TD style="VERTICAL-ALIGN: top; WIDTH: 32%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 67%"> For Period Ended: June 30, 2017</TD></TR> <TR> <TD style="VERTICAL-ALIGN: middle; WIDTH: 32%">  </TD> <TD style="VERTICAL-ALIGN: middle; WIDTH: 1%" colSpan=2>  </TD></TR> <TR> <TD style="VERTICAL-ALIGN: top; WIDTH: 32%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 67%"> ☐  Transition Report on Form 10-K</TD></TR> <TR> <TD style="VERTICAL-ALIGN: top; WIDTH: 32%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 67%"> ☐  Transition Report on Form 20-F</TD></TR> <TR> <TD style="VERTICAL-ALIGN: top; WIDTH: 32%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 67%"> ☐  Transition Report on Form 11-K</TD></TR> <TR> <TD style="VERTICAL-ALIGN: top; WIDTH: 32%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 67%"> ☐  Transition Report on Form 10-Q</TD></TR> <TR> <TD style="VERTICAL-ALIGN: top; WIDTH: 32%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 67%"> ☐  Transition Report on Form N-SAR</TD></TR> <TR> <TD style="VERTICAL-ALIGN: middle; WIDTH: 32%">  </TD> <TD style="VERTICAL-ALIGN: middle; WIDTH: 1%" colSpan=2>  </TD></TR> <TR> <TD style="VERTICAL-ALIGN: top; WIDTH: 32%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 67%"> For the Transition Period Ended:     </TD></TR></TABLE>   <TABLE id=TBL36 style="FONT-SIZE: 10pt; BORDER-TOP: #000000 1px solid; FONT-FAMILY: Times New Roman, Times, serif; BORDER-RIGHT: #000000 1px solid; BORDER-BOTTOM: #000000 1px solid; BORDER-LEFT: #000000 1px solid; WIDTH: 100%; TEXT-INDENT: 0px" cellSpacing=0 cellPadding=0 border=0> <TR> <TD style="VERTICAL-ALIGN: top; WIDTH: 100%"> Read Instruction (on back page) Before Preparing Form. Please Print or Type. Nothing in this form shall be construed to imply that the Commission has verified any information contained herein.</TD></TR></TABLE>   If the notification relates to a portion of the filing checked above, identify the Item(s) to which the notification relates:     <HR style="BORDER-TOP: medium none; HEIGHT: 2px; BORDER-RIGHT: medium none; BORDER-BOTTOM: medium none; COLOR: #000000; BORDER-LEFT: medium none; WIDTH: 100%; BACKGROUND-COLOR: #000000" align=center align="center"> PART I — REGISTRANT INFORMATION   BIO-TECHNE CORPORATION (Full Name of Registrant)   TECHNE CORPORATION (Former Name if Applicable)   614 McKinley Place NE (Address of Principal Executive Office (Street and Number))   Minneapolis, MN 55413 (City, State and Zip Code)   <DIV id=PGBK156 style="MARGIN-LEFT: 0pt; WIDTH: 100%; MARGIN-RIGHT: 0pt"> <DIV id=PGFTR156 style="TEXT-ALIGN: center; WIDTH: 100%"> </DIV> <DIV id=PGNUM156 style="FONT-SIZE: 10pt; TEXT-ALIGN: center; WIDTH: 100%"> </DIV> <HR style="HEIGHT: 2px; PAGE-BREAK-AFTER: always; COLOR: #000000; WIDTH: 100%" noShade> <DIV id=PGHDR156 style="TEXT-ALIGN: left; WIDTH: 100%"> </DIV></DIV>   <HR style="BORDER-TOP: medium none; HEIGHT: 2px; BORDER-RIGHT: medium none; BORDER-BOTTOM: medium none; COLOR: #000000; BORDER-LEFT: medium none; WIDTH: 100%; BACKGROUND-COLOR: #000000" align=center align="center"> PART II — RULES 12b-25(b) AND (c)   If the subject report could not be filed without unreasonable effort or expense and the registrant seeks relief pursuant to Rule 12b-25(b), the following should be completed. (Check box if appropriate)   <TABLE id=TBL77 style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman, Times, serif; WIDTH: 100%; TEXT-INDENT: 0px" cellSpacing=0 cellPadding=0 border=0> <TR> <TD style="BORDER-RIGHT: #000000 1px solid; VERTICAL-ALIGN: middle; WIDTH: 4%">    </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">  </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 2%"> (a)</TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">  </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 92%"> The reason described in reasonable detail in Part III of this form could not be eliminated without unreasonable effort or expense; </TD></TR> <TR> <TD style="BORDER-RIGHT: #000000 1px solid; VERTICAL-ALIGN: middle; WIDTH: 4%"> </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%"> </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 2%"> </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%"> </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 92%"> </TD></TR> <TR> <TD style="BORDER-RIGHT: #000000 1px solid; VERTICAL-ALIGN: middle; TEXT-ALIGN: center; WIDTH: 4%">☒</TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">  </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 2%"> (b)</TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">  </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 92%"> The subject annual report, semi-annual report, transition report on Form 10-K, Form 20-F, Form 11-K, Form N-SAR or Form N-CSR, or portion thereof, will be filed on or before the fifteenth calendar day following the prescribed due date; or the subject quarterly report or transition report on Form 10-Q or subject distribution report on Form 10-D, or portion thereof, will be filed on or before the fifth calendar day following the prescribed due date; and</TD></TR> <TR> <TD style="BORDER-RIGHT: #000000 1px solid; VERTICAL-ALIGN: middle; TEXT-ALIGN: center; WIDTH: 4%"> </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%"> </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 2%"> </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%"> </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 92%"> </TD></TR> <TR> <TD style="BORDER-RIGHT: #000000 1px solid; VERTICAL-ALIGN: middle; WIDTH: 4%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">  </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 2%"> (c)</TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">  </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 92%"> The accountant’s statement or other exhibit required by Rule 12b-25(c) has been attached if applicable.</TD></TR></TABLE>     <HR style="BORDER-TOP: medium none; HEIGHT: 2px; BORDER-RIGHT: medium none; BORDER-BOTTOM: medium none; COLOR: #000000; BORDER-LEFT: medium none; WIDTH: 100%; BACKGROUND-COLOR: #000000" align=center align="center"> PART III — NARRATIVE   State below in reasonable detail why Forms 10-K, 20-F, 11-K, 10-Q, 10-D, N-SAR, N-CSR, or the transition report or portion thereof, could not be filed within the prescribed time period.   Bio-Techne Corporation (the “Company”) is unable to file its Annual Report on Form 10-K for the year ended June 30, 2017 (the “Form 10-K”) within the prescribed time period without unreasonable effort or expense due to the greater-than-anticipated time, resources and effort required to complete work related to the assessment of the Company’s internal control over financial reporting. Management identified material weaknesses in internal controls at the end of its prior fiscal year. In response, during the fiscal year recently concluded on June 30, 2017, the Company redesigned a substantial number of controls, with a particular focus at several of our smaller locations acquired over the past several years. The Company believes it has made significant progress in changing the design of our controls as of June 30, 2017; however, the Company believes that material weaknesses still remain within some aspects of its internal control framework. Therefore, the Company requires some additional time to appropriately define and address the root causes of the material weaknesses and the path toward remediation prior to filing the Form 10-K. The Company currently does not expect any material changes to the results that have been reported in its previously disclosed results for the fourth quarter and 2017 fiscal year end. The Company expects to file the Form 10-K within the 15 calendar day period allowed under Rule 12b-25.   (Attach Extra Sheets if Needed)     <HR style="BORDER-TOP: medium none; HEIGHT: 2px; BORDER-RIGHT: medium none; BORDER-BOTTOM: medium none; COLOR: #000000; BORDER-LEFT: medium none; WIDTH: 100%; BACKGROUND-COLOR: #000000" align=center> PART IV — OTHER INFORMATION   <TABLE id=TBL95 style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman, Times, serif; WIDTH: 100%; TEXT-INDENT: 0px" cellSpacing=0 cellPadding=0 border=0> <TR> <TD style="VERTICAL-ALIGN: top; WIDTH: 4%"> (1) </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 96%"> Name and telephone number of person to contact in regard to this notification </TD></TR></TABLE>   <TABLE id=TBL111 style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman, Times, serif; MARGIN-LEFT: 27pt; WIDTH: 92%; MARGIN-RIGHT: 8%; TEXT-INDENT: 0px" cellSpacing=0 cellPadding=0 border=0> <TR> <TD style="VERTICAL-ALIGN: middle; WIDTH: 33%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">  </TD> <TD style="VERTICAL-ALIGN: middle; WIDTH: 2%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 2%">  </TD> <TD style="VERTICAL-ALIGN: middle; WIDTH: 24%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 2%">  </TD> <TD style="VERTICAL-ALIGN: middle; WIDTH: 2%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">  </TD> <TD style="VERTICAL-ALIGN: middle; WIDTH: 33%">  </TD></TR> <TR> <TD style="VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 1px solid; WIDTH: 33%"> James T. Hippel</TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">  </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 2%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 2%">     </TD> <TD style="VERTICAL-ALIGN: bottom; BORDER-BOTTOM: #000000 1px solid; WIDTH: 24%"> 612</TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 2%">   </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 2%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">   </TD> <TD style="VERTICAL-ALIGN: bottom; BORDER-BOTTOM: #000000 1px solid; WIDTH: 33%"> 656-4472</TD></TR> <TR> <TD style="VERTICAL-ALIGN: top; WIDTH: 33%"> (Name)</TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">  </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 2%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 2%">     </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 24%"> (Area Code)</TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 2%">   </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 2%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 1%">   </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 33%"> (Telephone Number)</TD></TR></TABLE>   <TABLE id=TBL115 style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman, Times, serif; WIDTH: 100%; TEXT-INDENT: 0px" cellSpacing=0 cellPadding=0 border=0> <TR> <TD style="VERTICAL-ALIGN: top; WIDTH: 4%"> (2) </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 96%"> Have all other periodic reports required under Section 13 or 15(d) of the Securities Exchange Act of 1934 or Section 30 of the Investment Company Act of 1940 during the preceding 12 months or for such shorter period that the registrant was required to file such report(s) been filed? If answer is no, identify report(s).    ☒  Yes    ☐  No </TD></TR></TABLE>    <DIV id=PGBK157 style="MARGIN-LEFT: 0pt; WIDTH: 100%; MARGIN-RIGHT: 0pt"> <DIV id=PGFTR157 style="TEXT-ALIGN: center; WIDTH: 100%"> </DIV> <DIV id=PGNUM157 style="FONT-SIZE: 10pt; TEXT-ALIGN: center; WIDTH: 100%"> </DIV> <HR style="HEIGHT: 2px; PAGE-BREAK-AFTER: always; COLOR: #000000; WIDTH: 100%" noShade> <DIV id=PGHDR157 style="TEXT-ALIGN: left; WIDTH: 100%"> </DIV></DIV>   <TABLE id=TBL119 style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman, Times, serif; WIDTH: 100%; TEXT-INDENT: 0px" cellSpacing=0 cellPadding=0 border=0> <TR> <TD style="VERTICAL-ALIGN: top; WIDTH: 4%"> (3) </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 96%"> Is it anticipated that any significant change in results of operations from the corresponding period for the last fiscal year will be reflected by the earnings statements to be included in the subject report or portion thereof?    ☒  Yes    ☐  No </TD></TR></TABLE>   If so, attach an explanation of the anticipated change, both narratively and quantitatively, and, if appropriate, state the reasons why a reasonable estimate of the results cannot be made.   For a comparison of the Company’s fourth quarter and annual fiscal year 2017 and 2016 financial results, please refer to the Company’s press release, dated August 8, 2017, that was furnished as Exhibit 99.1 to the Company’s Current Report on Form 8-K, dated August 8, 2017. Notwithstanding the Company’s inability to file the Form 10-K within the prescribed time period, the Company currently does not expect any material changes to the results that have been reported in the press release.       <HR style="BORDER-TOP: medium none; HEIGHT: 2px; BORDER-RIGHT: medium none; BORDER-BOTTOM: medium none; COLOR: #000000; BORDER-LEFT: medium none; WIDTH: 100%; BACKGROUND-COLOR: #000000" align=center> Bio-Techne Corporation has caused this notification to be signed on its behalf by the undersigned hereunto duly authorized.   <TABLE id=TBL141 style="FONT-SIZE: 10pt; FONT-FAMILY: Times New Roman, Times, serif; WIDTH: 100%; TEXT-INDENT: 0px" cellSpacing=0 cellPadding=0 border=0> <TR> <TD style="VERTICAL-ALIGN: top; WIDTH: 4.6%"> Date </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 43.6%"> August 29, 2017</TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 0.7%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 2.7%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 0.7%">  </TD> <TD style="VERTICAL-ALIGN: top; WIDTH: 3%"> By </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 0.7%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 0.1%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 0.7%">  </TD> <TD style="VERTICAL-ALIGN: bottom; WIDTH: 42.6%"> /s/ James T. Hippel Name: James T. Hippel Title: Chief Financial Officer</TD></TR></TABLE>   INSTRUCTION: The form may be signed by an executive officer of the registrant or by any other duly authorized representative. The name and title of the person signing the form shall be typed or printed beneath the signature. If the statement is signed on behalf of the registrant by an authorized representative (other than an executive officer), evidence of the representative’s authority to sign on behalf of the registrant shall be filed with the form.   <TABLE id=TBL148 style="FONT-SIZE: 10pt; BORDER-TOP: #000000 1px solid; FONT-FAMILY: Times New Roman, Times, serif; BORDER-RIGHT: #000000 1px solid; BORDER-BOTTOM: #000000 1px solid; BORDER-LEFT: #000000 1px solid; WIDTH: 100%; TEXT-INDENT: 0px" cellSpacing=0 cellPadding=0 border=0> <TR> <TD style="VERTICAL-ALIGN: top; WIDTH: 100%"> ATTENTION   Intentional misstatements or omissions of fact constitute Federal Criminal Violations (See 18 U.S.C. 1001).</TD></TR></TABLE>  </BODY></HTML>