Classification of Multiple Sclerosis Clinical Profiles via Graph Convolutional Neural Networks - ANR

<!DOCTYPE html> <html xmlns="http://www.w3.org/1999/xhtml" lang="fr"> <head> <meta charset="UTF-8"> <meta name="viewport" content="width=device-width, initial-scale=1, shrink-to-fit=no"> <link href="http://purl.org/dc/elements/1.1/" rel="schema.DC"> <meta name="citation_language" content="en" /> <meta name="DC.language" content="en" /> <meta name="DC.type" content="journal" /> <meta property="og:type" content="journal" /> <meta name="citation_title" content="Classification of Multiple Sclerosis Clinical Profiles via Graph Convolutional Neural Networks" /> <meta name="DC.title" content="Classification of Multiple Sclerosis Clinical Profiles via Graph Convolutional Neural Networks" /> <meta property="og:title" content="Classification of Multiple Sclerosis Clinical Profiles via Graph Convolutional Neural Networks" /> <meta name="DC.identifier" content="https://hal.science/hal-04649405" /> <meta name="DC.identifier" content="hal-04649405" /> <meta property="og:url" content="https://hal.science/hal-04649405" /> <meta name="citation_author" content="A. Marzullo" /> <meta name="citation_author_institution" content="Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé" /> <meta name="citation_author_institution" content="Università della Calabria [Arcavacata di Rende, Italia] = University of Calabria [Italy] = Université de Calabre [Italie]" /> <meta name="DC.creator" content="A. Marzullo" /> <meta name="citation_author" content="G. Kocevar" /> <meta name="citation_author_hal_id" content="kocevar-gabriel" /> <meta name="citation_author_institution" content="Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé" /> <meta name="DC.creator" content="G. Kocevar" /> <meta name="citation_author" content="C. Stamile" /> <meta name="citation_author_institution" content="RMN et optique : De la mesure au biomarqueur" /> <meta name="DC.creator" content="C. Stamile" /> <meta name="citation_author" content="F. Durand-Dubief" /> <meta name="citation_author_hal_id" content="francoise-durand-dubief" /> <meta name="citation_author_institution" content="Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL]" /> <meta name="citation_author_institution" content="RMN et optique : De la mesure au biomarqueur" /> <meta name="DC.creator" content="F. Durand-Dubief" /> <meta name="citation_author" content="G. Terracina" /> <meta name="citation_author_institution" content="Università della Calabria [Arcavacata di Rende, Italia] = University of Calabria [Italy] = Université de Calabre [Italie]" /> <meta name="DC.creator" content="G. Terracina" /> <meta name="citation_author" content="F. Calimeri" /> <meta name="citation_author_institution" content="Università della Calabria [Arcavacata di Rende, Italia] = University of Calabria [Italy] = Université de Calabre [Italie]" /> <meta name="DC.creator" content="F. Calimeri" /> <meta name="citation_author" content="D. Sappey-Marinier" /> <meta name="citation_author_hal_id" content="dominique-sappey-marinier" /> <meta name="citation_author_institution" content="Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé" /> <meta name="citation_author_institution" content="Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant" /> <meta name="DC.creator" content="D. Sappey-Marinier" /> <meta name="citation_abstract" content="Recent advances in image acquisition and processing techniques, along with the success of novel deep learning architectures, have given the opportunity to develop innovative algorithms capable to provide a better characterization of neurological related diseases. In this work, we introduce a neural network based approach to classify Multiple Sclerosis (MS) patients into four clinical profiles. Starting from their structural connectivity information, obtained by diffusion tensor imaging and represented as a graph, we evaluate the classification performances using unweighted and weighted connectivity matrices. Furthermore, we investigate the role of graph-based features for a better characterization and classification of the pathology. Ninety MS patients (12 clinically isolated syndrome, 30 relapsing-remitting, 28 secondary-progressive, and 20 primary-progressive) along with 24 healthy controls, were considered in this study. This work shows the great performances achieved by neural networks methods in the classification of the clinical profiles. Furthermore, it shows local graph metrics do not improve the classification results suggesting that the latent features created by the neural network in its layers have a much important informative content. Finally, we observe that graph weights representation of brain connections preserve important information to discriminate between clinical forms." /> <meta name="DC.description" content="Recent advances in image acquisition and processing techniques, along with the success of novel deep learning architectures, have given the opportunity to develop innovative algorithms capable to provide a better characterization of neurological related diseases. In this work, we introduce a neural network based approach to classify Multiple Sclerosis (MS) patients into four clinical profiles. Starting from their structural connectivity information, obtained by diffusion tensor imaging and represented as a graph, we evaluate the classification performances using unweighted and weighted connectivity matrices. Furthermore, we investigate the role of graph-based features for a better characterization and classification of the pathology. Ninety MS patients (12 clinically isolated syndrome, 30 relapsing-remitting, 28 secondary-progressive, and 20 primary-progressive) along with 24 healthy controls, were considered in this study. This work shows the great performances achieved by neural networks methods in the classification of the clinical profiles. Furthermore, it shows local graph metrics do not improve the classification results suggesting that the latent features created by the neural network in its layers have a much important informative content. Finally, we observe that graph weights representation of brain connections preserve important information to discriminate between clinical forms." /> <meta name="description" content="Recent advances in image acquisition and processing techniques, along with the success of novel deep learning architectures, have given the opportunity to develop innovative algorithms capable to provide a better characterization of neurological related diseases. In this work, we introduce a neural network based approach to classify Multiple Sclerosis (MS) patients into four clinical profiles. Starting from their structural connectivity information, obtained by diffusion tensor imaging and represented as a graph, we evaluate the classification performances using unweighted and weighted connectivity matrices. Furthermore, we investigate the role of graph-based features for a better characterization and classification of the pathology. Ninety MS patients (12 clinically isolated syndrome, 30 relapsing-remitting, 28 secondary-progressive, and 20 primary-progressive) along with 24 healthy controls, were considered in this study. This work shows the great performances achieved by neural networks methods in the classification of the clinical profiles. Furthermore, it shows local graph metrics do not improve the classification results suggesting that the latent features created by the neural network in its layers have a much important informative content. Finally, we observe that graph weights representation of brain connections preserve important information to discriminate between clinical forms." /> <meta property="og:description" content="Recent advances in image acquisition and processing techniques, along with the success of novel deep learning architectures, have given the opportunity to develop innovative algorithms capable to provide a better characterization of neurological related diseases. In this work, we introduce a neural network based approach to classify Multiple Sclerosis (MS) patients into four clinical profiles. Starting from their structural connectivity information, obtained by diffusion tensor imaging and represented as a graph, we evaluate the classification performances using unweighted and weighted connectivity matrices. Furthermore, we investigate the role of graph-based features for a better characterization and classification of the pathology. Ninety MS patients (12 clinically isolated syndrome, 30 relapsing-remitting, 28 secondary-progressive, and 20 primary-progressive) along with 24 healthy controls, were considered in this study. This work shows the great performances achieved by neural networks methods in the classification of the clinical profiles. Furthermore, it shows local graph metrics do not improve the classification results suggesting that the latent features created by the neural network in its layers have a much important informative content. Finally, we observe that graph weights representation of brain connections preserve important information to discriminate between clinical forms." /> <meta name="citation_keywords" content="connectome;diffusion tensor imaging;graph neural networks;graph-derived metrics;multiple sclerosis" /> <meta name="DC.subject" content="connectome;diffusion tensor imaging;graph neural networks;graph-derived metrics;multiple sclerosis" /> <meta name="keywords" content="connectome;diffusion tensor imaging;graph neural networks;graph-derived metrics;multiple sclerosis" /> <meta name="citation_pdf_url" content="https://hal.science/hal-04649405/document" /> <meta name="DC.identifier" content="https://hal.science/hal-04649405/document" /> <meta property="og:url" content="https://hal.science/hal-04649405/document" /> <meta name="citation_online_date" content="2024/11/27" /> <meta name="citation_publication_date" content="2019" /> <meta name="DC.date" content="2019" /> <meta name="DC.issued" content="2019" /> <meta name="citation_volume" content="13" /> <meta name="DC.citation.volume" content="13" /> <meta name="citation_firstpage" content="594" /> <meta name="citation_journal_title" content="Frontiers in Neuroscience" /> <meta name="DC.relation.ispartof" content="Frontiers in Neuroscience" /> <meta name="citation_doi" content="10.3389/fnins.2019.00594" /> <meta name="citation_pmid" content="31244599" /> <meta name="citation_id" content="PMC6581753" /> <meta name="citation_funding_source" content="citation_funder=Agence Nationale de la Recherche; 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id="document" value="" class="input-flex form-control input-sm" lang="title_t" aria-describedby="document-error" style=" " data-keyword="1" /><span class="input-group-btn"><button type='button' class='btn btn-sm btn-primary form-btn-multi form-btn-add' onclick='MultiTextSimpleLangKeywordAdd(this, "qa");' data-toggle='tooltip' data-placement='right' data-original-title='Ajouter'><i class='icon icon-plus'></i> <span> Ajouter</span></button></span></div></div></div> <div class="form-group row " id="author-element"><label for="author" class="col-md-3 control-label optional">Auteur</label> <div class="col-md-9"><div class="input-group" style="margin-bottom : 10px;"><button class='btn btn-sm btn-default dropdown-toggle form-btn-lang' style=' z-index:0!important;' data-toggle='dropdown' type='button' value='auth_t'>Auteur (multicritères) </button><ul class='dropdown-menu' role='menu' style='max-height: 140px; overflow:auto;'><li class='dropdown-item'><a data-val='auth_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur (multicritères)</a></li><li class='dropdown-item'><a data-val='authFullName_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : Nom complet</a></li><li class='dropdown-item'><a data-val='authLastName_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : Nom de famille</a></li><li class='dropdown-item'><a data-val='authFirstName_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : Prénom</a></li><li class='dropdown-item'><a data-val='authMiddleName_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : Complément de nom, deuxième prénom</a></li><li class='dropdown-item'><a data-val='authOrganism_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : Organisme payeur</a></li><li class='dropdown-item'><a data-val='authIdHal_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : IdHal (chaîne de caractères)</a></li><li class='dropdown-item'><a data-val='authQuality_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : Fonction</a></li><li class='dropdown-item'><a data-val='authIdHal_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : personID (entier)</a></li><li class='dropdown-item'><a data-val='authOrganismId_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : Identifiant de l'organisme payeur</a></li><li class='dropdown-item'><a data-val='authStructId_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Auteur : Identifiant de la structure</a></li><li class='dropdown-item'><a data-val='director_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Directeur de thèse</a></li><li class='dropdown-item'><a data-val='publisher_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Éditeur</a></li><li class='dropdown-item'><a data-val='scientificEditor_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Éditeur scientifique</a></li><li class='dropdown-item'><a data-val='seriesEditor_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Éditeur de la série</a></li></ul> <input type="text" name="qa[auth_t][]" id="author" value="" class="input-flex form-control input-sm" lang="auth_t" aria-describedby="author-error" style=" " data-keyword="1" /><span class="input-group-btn"><button type='button' class='btn btn-sm btn-primary form-btn-multi form-btn-add' onclick='MultiTextSimpleLangKeywordAdd(this, "qa");' data-toggle='tooltip' data-placement='right' data-original-title='Ajouter'><i class='icon icon-plus'></i> <span> Ajouter</span></button></span></div></div></div> <div class="form-group row " id="structure-element"><label for="structure" class="col-md-3 control-label optional">Structure</label> <div class="col-md-9"><div class="input-group" style="margin-bottom : 10px;"><button class='btn btn-sm btn-default dropdown-toggle form-btn-lang' style=' z-index:0!important;' data-toggle='dropdown' type='button' value='structure_t'>Structure (multicritères) </button><ul class='dropdown-menu' role='menu' style='max-height: 140px; overflow:auto;'><li class='dropdown-item'><a data-val='structure_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure (multicritères)</a></li><li class='dropdown-item'><a data-val='structAcronym_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure : Acronyme</a></li><li class='dropdown-item'><a data-val='structName_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure : Nom</a></li><li class='dropdown-item'><a data-val='structCode_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure : Code</a></li><li class='dropdown-item'><a data-val='structCountry_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure : Pays</a></li><li class='dropdown-item'><a data-val='structType_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure : Type</a></li><li class='dropdown-item'><a data-val='structValid_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure : État dans le référentiel</a></li><li class='dropdown-item'><a data-val='structId_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure : Identifiant HAL de la structure</a></li><li class='dropdown-item'><a data-val='rteamStructCountry_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure/équipe de recherche : Pays</a></li><li class='dropdown-item'><a data-val='deptStructCountry_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure/regroupement d'équipes : Pays</a></li><li class='dropdown-item'><a data-val='labStructCountry_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure/laboratoire : Pays</a></li><li class='dropdown-item'><a data-val='rgrpLabStructCountry_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure/regroupement de laboratoires : Pays</a></li><li class='dropdown-item'><a data-val='instStructCountry_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure/institution : Pays</a></li><li class='dropdown-item'><a data-val='rgrpInstStructCountry_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Structure/regroupement d'institutions : Pays</a></li></ul> <input type="text" name="qa[structure_t][]" id="structure" value="" class="input-flex form-control input-sm" lang="structure_t" aria-describedby="structure-error" style=" " data-keyword="1" /><span class="input-group-btn"><button type='button' class='btn btn-sm btn-primary form-btn-multi form-btn-add' onclick='MultiTextSimpleLangKeywordAdd(this, "qa");' data-toggle='tooltip' data-placement='right' data-original-title='Ajouter'><i class='icon icon-plus'></i> <span> Ajouter</span></button></span></div></div></div> <div class="form-group row " id="qa-element"><label for="qa" class="col-md-3 control-label optional">Autres</label> <div class="col-md-9"><div class="input-group" style="margin-bottom : 10px;"><button class='btn btn-sm btn-default dropdown-toggle form-btn-lang' style=' z-index:0!important;' data-toggle='dropdown' type='button' value='text'>Champ de recherche par défaut (multicritères) </button><ul class='dropdown-menu' role='menu' style='max-height: 140px; overflow:auto;'><li class='dropdown-item'><a data-val='text' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Champ de recherche par défaut (multicritères)</a></li><li class='dropdown-item'><a data-val='--sep1' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='anrProject_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projets ANR (multicritères)</a></li><li class='dropdown-item'><a data-val='anrProjectAcronym_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet ANR : Acronyme</a></li><li class='dropdown-item'><a data-val='anrProjectAcronymProgram_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet ANR : Acronyme du programme</a></li><li class='dropdown-item'><a data-val='anrProjectReference_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet ANR : Code décision (référence)</a></li><li class='dropdown-item'><a data-val='anrProjectTitle_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet ANR : Nom</a></li><li class='dropdown-item'><a data-val='anrProjectId_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet ANR : Identifiant interne</a></li><li class='dropdown-item'><a data-val='--sep2' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='journal_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revues (multicritères)</a></li><li class='dropdown-item'><a data-val='journalPublisher_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : Éditeur</a></li><li class='dropdown-item'><a data-val='journalTitleAbbr_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : Titre abrégé</a></li><li class='dropdown-item'><a data-val='journalTitle_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : Titre</a></li><li class='dropdown-item'><a data-val='journalId_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : Identifiant interne</a></li><li class='dropdown-item'><a data-val='journalDate_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : Date de début de publication</a></li><li class='dropdown-item'><a data-val='journalEissn_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : ISSN électronique</a></li><li class='dropdown-item'><a data-val='journalIssn_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : ISSN</a></li><li class='dropdown-item'><a data-val='journalPublisher_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : Éditeur</a></li><li class='dropdown-item'><a data-val='journalSherpaColor_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : Couleur dans SHERPA/RoMEO</a></li><li class='dropdown-item'><a data-val='journalValid_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Revue : État dans le référentiel</a></li><li class='dropdown-item'><a data-val='--sep3' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='conference_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Colloque (multicritères)</a></li><li class='dropdown-item'><a data-val='conferenceTitle_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Colloque : Titre</a></li><li class='dropdown-item'><a data-val='conferenceOrganizer_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Colloque : Organisateur</a></li><li class='dropdown-item'><a data-val='conferenceStartDateY_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Colloque : date de début (Année)</a></li><li class='dropdown-item'><a data-val='conferenceEndDateY_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Colloque : date de fin (Année)</a></li><li class='dropdown-item'><a data-val='invitedCommunication_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Conférence invitée (oui/non)</a></li><li class='dropdown-item'><a data-val='--sep4' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='europeanProject_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projets européens (multicritères)</a></li><li class='dropdown-item'><a data-val='europeanProjectAcronym_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet européen : Acronyme</a></li><li class='dropdown-item'><a data-val='europeanProjectCallId_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet européen : Identifiant de l'appel à projet</a></li><li class='dropdown-item'><a data-val='europeanProjectReference_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet européen : Référence</a></li><li class='dropdown-item'><a data-val='europeanProjectTitle_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet européen : Nom</a></li><li class='dropdown-item'><a data-val='europeanProjectEndDate_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet européen : Date de fin</a></li><li class='dropdown-item'><a data-val='europeanProjectFinancing_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet européen : Financement</a></li><li class='dropdown-item'><a data-val='europeanProjectStartDate_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet européen : Date de début</a></li><li class='dropdown-item'><a data-val='europeanProjectValid_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet européen : État dans le référentiel</a></li><li class='dropdown-item'><a data-val='europeanProjectId_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Projet européen : Identifiant interne</a></li><li class='dropdown-item'><a data-val='--sep6' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='producedDateY_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Date de production : année</a></li><li class='dropdown-item'><a data-val='releasedDateY_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Date de mise en ligne : année</a></li><li class='dropdown-item'><a data-val='publicationDateY_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Date de publication : année</a></li><li class='dropdown-item'><a data-val='writingDateY_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Date d'écriture : année</a></li><li class='dropdown-item'><a data-val='modifiedDateY_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Date de modification du dépôt : année</a></li><li class='dropdown-item'><a data-val='submittedDateY_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Date de dépôt : année</a></li><li class='dropdown-item'><a data-val='ePublicationDateY_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Date de publication électronique : année</a></li><li class='dropdown-item'><a data-val='--sep7' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='collection_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Collection HAL (multicritères)</a></li><li class='dropdown-item'><a data-val='collCategory_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Collection HAL : catégorie</a></li><li class='dropdown-item'><a data-val='collCode_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Collection HAL : Code</a></li><li class='dropdown-item'><a data-val='collName_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Collection HAL : Nom</a></li><li class='dropdown-item'><a data-val='collId_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Collection HAL : Identifiant interne</a></li><li class='dropdown-item'><a data-val='--sep8' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='contributorId_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Identifiant interne du contributeur/déposant</a></li><li class='dropdown-item'><a data-val='contributorFullName_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Nom complet du contributeur/déposant</a></li><li class='dropdown-item'><a data-val='--sep9' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='domain_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Domaines</a></li><li class='dropdown-item'><a data-val='primaryDomain_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Domaine primaire</a></li><li class='dropdown-item'><a data-val='level0_domain_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Domaine racine</a></li><li class='dropdown-item'><a data-val='level1_domain_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Sous-domaine niveau 1</a></li><li class='dropdown-item'><a data-val='level2_domain_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Sous-domaine niveau 2</a></li><li class='dropdown-item'><a data-val='level3_domain_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Sous-domaine niveau 3</a></li><li class='dropdown-item'><a data-val='--sep10' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='status_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Statut du document</a></li><li class='dropdown-item'><a data-val='version_i' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Version du document</a></li><li class='dropdown-item'><a data-val='submitType_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Type de dépôt</a></li><li class='dropdown-item'><a data-val='docType_s' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Type de document</a></li><li class='dropdown-item'><a data-val='isbn_id' href='javascript:void(0);' onclick="LangInit(this, 'qa');">ISBN</a></li><li class='dropdown-item'><a data-val='number_id' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Numéro - référence</a></li><li class='dropdown-item'><a data-val='doiId_id' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Identifiant DOI</a></li><li class='dropdown-item'><a data-val='--sep11' href='javascript:void(0);' onclick="LangInit(this, 'qa');"></a></li><li class='dropdown-item'><a data-val='classification_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Classification</a></li><li class='dropdown-item'><a data-val='audience_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Audience</a></li><li class='dropdown-item'><a data-val='popularLevel_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Vulgarisation</a></li><li class='dropdown-item'><a data-val='peerReviewing_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Comité de lecture - texte (oui ou non)</a></li><li class='dropdown-item'><a data-val='proceedings_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Actes de colloque</a></li><li class='dropdown-item'><a data-val='localReference_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Référence interne</a></li><li class='dropdown-item'><a data-val='funding_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Financement</a></li><li class='dropdown-item'><a data-val='collaboration_t' href='javascript:void(0);' onclick="LangInit(this, 'qa');">Collaborations</a></li></ul> <input type="text" name="qa[text][]" id="qa" value="" lang="text" class=" form-control input-sm" aria-describedby="qa-error" style=" " data-keyword="1" /><span class="input-group-btn"><button type='button' class='btn btn-sm btn-primary form-btn-multi form-btn-add' onclick='MultiTextSimpleLangKeywordAdd(this, "qa");' data-toggle='tooltip' data-placement='right' data-original-title='Ajouter'><i class='icon icon-plus'></i> <span> Ajouter</span></button></span></div></div></div> <dt id="submit-label"> </dt><dd id="submit-element"> <button name="submit" id="submit-button" type="submit" value=" Lancer la recherche" class="btn btn-lg btnSearch hal-visualize-button" aria-describedby="submit-button-error"> Lancer la recherche</button></dd></form> <div class="mt-3"> <button class="tools-color btn-hide-show" data-selectOne="#solrSearchHeader" data-selectTwo="#advSearchHeader"> <span>Recherche experte (SolR)</span> </button> </div> </div> <div id="solrSearchHeader" class="hide"> <h3> Recherche experte (SolR)</h3> <form action="/search/index" method="get" id="searchHeaderSolr" name="search-simple" role="search"> <textarea type="text" name="q" class="p-5" autocomplete="off" cols="150" placeholder="Chercher un document, un auteur, un mot clef..." value=""></textarea> <div> <button type="submit" aria-label="Rechercher" class="hal-visualize-button"> <span class="icon-search" aria-hidden="true"></span> <span>Lancer la recherche</span> </button> </div> </form> <div class="mt-3"> <button class="tools-color btn-hide-show" data-selectOne="#solrSearchHeader" data-selectTwo="#advSearchHeader"> <span>Vers la recherche avancée</span> </button> </div> </div> </div> </div> </li> <li id="ssheader-submit" class="btn-primary-orange position-relative"> <a href="https://hal.science/submit/index" class="btn-hal hal-submit-button btn-primary-orange stretched-link"> <span class="icon-add colo-white" aria-hidden="true"></span> <span> Déposer dans HAL </span> </a> </li> </ul> </nav> <div class="site-header logo"> <div class="section-corps"> <table width="100%" cellpadding="0" style="position:relative;"> <tr> <td align="left"><span class="title"></span></td> </tr> </table> </div> </div> <div class="website-navigation"> <ul class="nav nav-pills justify-content-center flex-column flex-md-row"> <li class="nav-item "> <a class="nav-link " href="/" target="" >Accueil</a> </li> <li class="nav-item dropdown "> <a class="nav-link dropdown-toggle " data-toggle="dropdown" href="#" role="button" aria-haspopup="true" aria-expanded="false" target="" >Consulter</a> <ul class="dropdown-menu dropdown-menu-right"> <li class="nav-item"> <a class="dropdown-item" href="/browse/period" target="">Consultation par année</a> </li> <li class="nav-item"> <a class="dropdown-item" href="/browse/domain" target="">Consultation par domaine</a> </li> <li class="nav-item"> <a class="dropdown-item" href="/browse/institution" target="">Consultation par structure de recherche</a> </li> <li class="nav-item"> <a class="dropdown-item" href="/browse/doctype" target="">Consultation par type de publication</a> </li> <li class="nav-item"> <a class="dropdown-item" href="/browse/latest-publications" target="">Consultation des dernières publications</a> </li> </ul> </li> <li class="nav-item "> <a class="nav-link " href="https://hal.science/submit/index" target="_blank" >Dépôt sur HAL</a> </li> <li class="nav-item dropdown "> <a class="nav-link dropdown-toggle " data-toggle="dropdown" href="#" role="button" aria-haspopup="true" aria-expanded="false" target="" >Les productions éditoriales de l'ANR</a> <ul class="dropdown-menu dropdown-menu-right"> <li class="nav-item"> <a class="dropdown-item" href="/search/index/?qa[contributorFullName_t][]=anr&qa[journalId_i][]=58987&submit_advanced=Rechercher" target="_blank">Les cahiers</a> </li> <li class="nav-item"> <a class="dropdown-item" href="https://anr.hal.science/search/index/?qa[keyword_t][]=Focus+de+l%E2%80%99ANR&qa[auth_t][]=&qa[structure_t][]=&qa[contributorFullName_t][]=ANR&qa[contributorFullName_t][]=&submit_advanced=Rechercher" target="_blank">Les focus</a> </li> <li class="nav-item"> <a class="dropdown-item" href="search/index/?qa[keyword_t][]=France+2030&qa[keyword_t][]=&qa[auth_t][]=&qa[structure_t][]=&qa[text][]=&submit=+Lancer+la+recherche" target="_blank">France 2030</a> </li> <li class="nav-item"> <a class="dropdown-item" href="https://anr.hal.science/search/index/?qa%5Bkeyword_t%5D%5B%5D=Autres+productions&qa%5Bkeyword_t%5D%5B%5D=&qa%5Bauth_t%5D%5B%5D=&qa%5Bstructure_t%5D%5B%5D=&qa%5BcontributorFullName_t%5D%5B%5D=anr&qa%5BcontributorFullName_t%5D%5B%5D=&submit=+Lancer+la+recherche&rows=30" target="_blank">Autres productions</a> </li> </ul> </li> </ul> </div> <main> <div id="skip-link" tabindex="-1"></div> <div class="toast hide valid-bg toast-valid" role="alert" aria-live="assertive" aria-atomic="true"> <div class="toast-body"> <div class="message"> <span class="icon-valid" aria-hidden="true"></span> <span class="flash-messages"> </span> </div> <button type="button" class="ml-2 mb-1 close" 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class="spinner-border text-light" role="status"> <span class="sr-only">Loading...</span> </div> <span class="flash-messages"> </span> </div> <button type="button" class="ml-2 mb-1 close" data-dismiss="toast" aria-label="Close"> <span aria-hidden="true">×</span> </button> </div> </div> <script type="text/javascript"> $(document).ready(function() { }); </script> <section class="section-corps row"> <div id="flash-messages"></div> <section class="col-12 col-md-9 order-sm-12 flex-74"> <div class="header-section"> <span class="typdoc label_ART">Article Dans Une Revue </span> <span class="journal text-small">Frontiers in Neuroscience</span> <span class="year strong">Année : 2019</span> </div> <div class="section-content section-shadow"> <div style="display: flex; justify-content: space-between;"> <div style="display: flex; align-items: center;"> <h2 class="title-lang en active" lang="en" style="margin-bottom: 0;">Classification of Multiple Sclerosis Clinical Profiles via Graph Convolutional Neural Networks</h2> </div> <div> <span style="margin-left: 2%; margin-right: 3%"></span> </div> </div> <span></span> <div id="authors-simplified"> <div class="authors"> <a type="button" data-toggle="popover" class="btn-popover no-hide" data-container="body" data-placement="right" data-title="" data-content=" <div class='popover-authors'> <div class='popover-author-header'> <h4>Auteur</h4> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> </div> <a class='popover-affil' href="/search/index/q/*/structId_i/139739">Centre de Recherche en Acquisition et Traitement de l&#039;Image pour la Santé</a> <a class='popover-affil' href="/search/index/q/*/structId_i/103704">Università della Calabria [Arcavacata di Rende, Italia] = University of Calabria [Italy] = Université de Calabre [Italie]</a> <a href="/search/index/q/*/authFullName_s/A.+Marzullo" title="Search author" target="_blank"> <div class='popover-resume hal-privilege-button'> <span class='icon-search hal-icon'></span> Chercher dans HAL </div> </a> </div> "> <span>A. Marzullo</span> </a> (1, 2) , <a type="button" data-toggle="popover" class="btn-popover no-hide" data-container="body" data-placement="right" data-title="" data-content=" <div class='popover-authors'> <div class='popover-author-header'> <h4>Auteur</h4> <ul> <li>Fonction : <strong>Auteur</strong></li> <li>PersonId : <strong>21385</strong></li> <li>IdHAL : <a href="/search/index/q/*/authIdHal_s/kocevar-gabriel" target="_blank" title="Consulter les publications"><strong>kocevar-gabriel</strong></a></li> <li>ORCID : <strong><a href="https://orcid.org/0000-0003-4130-6498" title="ORCID" target="_blank">0000-0003-4130-6498</a></strong></li> <li>IdRef : <strong><a href="https://www.idref.fr/203646177" title="IdRef" target="_blank">203646177</a></strong></li> </ul> </div> <a class='popover-affil' href="/search/index/q/*/structId_i/139739">Centre de Recherche en Acquisition et Traitement de l&#039;Image pour la Santé</a> <a href="/search/index/q/*/authIdHal_s/kocevar-gabriel" title="Search author" target="_blank"> <div class='popover-resume hal-privilege-button'> <span class='icon-search hal-icon'></span> Chercher dans HAL </div> </a> </div> "> <span>G. Kocevar</span> </a> (1) , <a type="button" data-toggle="popover" class="btn-popover no-hide" data-container="body" data-placement="right" data-title="" data-content=" <div class='popover-authors'> <div class='popover-author-header'> <h4>Auteur</h4> <ul> <li>Fonction : <strong>Auteur</strong></li> <li>PersonId : <strong>1450697</strong></li> <li>ORCID : <strong><a href="https://orcid.org/0000-0003-3291-2592" title="ORCID" target="_blank">0000-0003-3291-2592</a></strong></li> </ul> </div> <a class='popover-affil' href="/search/index/q/*/structId_i/530749">RMN et optique : De la mesure au biomarqueur</a> <a href="/search/index/q/*/authIdHal_i/1450697" title="Search author" target="_blank"> <div class='popover-resume hal-privilege-button'> <span class='icon-search hal-icon'></span> Chercher dans HAL </div> </a> </div> "> <span>C. Stamile</span> </a> (3) , <a type="button" data-toggle="popover" class="btn-popover no-hide" data-container="body" data-placement="right" data-title="" data-content=" <div class='popover-authors'> <div class='popover-author-header'> <h4>Auteur</h4> <ul> <li>Fonction : <strong>Auteur</strong></li> <li>PersonId : <strong>172702</strong></li> <li>IdHAL : <a href="/search/index/q/*/authIdHal_s/francoise-durand-dubief" target="_blank" title="Consulter les publications"><strong>francoise-durand-dubief</strong></a></li> <li>ORCID : <strong><a href="https://orcid.org/0000-0002-2860-1700" title="ORCID" target="_blank">0000-0002-2860-1700</a></strong></li> <li>IdRef : <strong><a href="https://www.idref.fr/15778911X" title="IdRef" target="_blank">15778911X</a></strong></li> </ul> </div> <a class='popover-affil' href="/search/index/q/*/structId_i/300873">Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL]</a> <a class='popover-affil' href="/search/index/q/*/structId_i/530749">RMN et optique : De la mesure au biomarqueur</a> <a href="/search/index/q/*/authIdHal_s/francoise-durand-dubief" title="Search author" target="_blank"> <div class='popover-resume hal-privilege-button'> <span class='icon-search hal-icon'></span> Chercher dans HAL </div> </a> </div> "> <span>F. Durand-Dubief</span> </a> (4, 3) , <a type="button" data-toggle="popover" class="btn-popover no-hide" data-container="body" data-placement="right" data-title="" data-content=" <div class='popover-authors'> <div class='popover-author-header'> <h4>Auteur</h4> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> </div> <a class='popover-affil' href="/search/index/q/*/structId_i/103704">Università della Calabria [Arcavacata di Rende, Italia] = University of Calabria [Italy] = Université de Calabre [Italie]</a> <a href="/search/index/q/*/authFullName_s/G.+Terracina" title="Search author" target="_blank"> <div class='popover-resume hal-privilege-button'> <span class='icon-search hal-icon'></span> Chercher dans HAL </div> </a> </div> "> <span>G. Terracina</span> </a> (2) , <a type="button" data-toggle="popover" class="btn-popover no-hide" data-container="body" data-placement="right" data-title="" data-content=" <div class='popover-authors'> <div class='popover-author-header'> <h4>Auteur</h4> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> </div> <a class='popover-affil' href="/search/index/q/*/structId_i/103704">Università della Calabria [Arcavacata di Rende, Italia] = University of Calabria [Italy] = Université de Calabre [Italie]</a> <a href="/search/index/q/*/authFullName_s/F.+Calimeri" title="Search author" target="_blank"> <div class='popover-resume hal-privilege-button'> <span class='icon-search hal-icon'></span> Chercher dans HAL </div> </a> </div> "> <span>F. Calimeri</span> </a> (2) , <a type="button" data-toggle="popover" class="btn-popover no-hide" data-container="body" data-placement="right" data-title="" data-content=" <div class='popover-authors'> <div class='popover-author-header'> <h4>Auteur</h4> <ul> <li>Fonction : <strong>Auteur</strong></li> <li>PersonId : <strong>170664</strong></li> <li>IdHAL : <a href="/search/index/q/*/authIdHal_s/dominique-sappey-marinier" target="_blank" title="Consulter les publications"><strong>dominique-sappey-marinier</strong></a></li> <li>ORCID : <strong><a href="https://orcid.org/0000-0003-4104-1514" title="ORCID" target="_blank">0000-0003-4104-1514</a></strong></li> <li>IdRef : <strong><a href="https://www.idref.fr/033214344" title="IdRef" target="_blank">033214344</a></strong></li> </ul> </div> <a class='popover-affil' href="/search/index/q/*/structId_i/139739">Centre de Recherche en Acquisition et Traitement de l&#039;Image pour la Santé</a> <a class='popover-affil' href="/search/index/q/*/structId_i/5460">Centre d&#039;Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant</a> <a href="/search/index/q/*/authIdHal_s/dominique-sappey-marinier" title="Search author" target="_blank"> <div class='popover-resume hal-privilege-button'> <span class='icon-search hal-icon'></span> Chercher dans HAL </div> </a> </div> "> <span>D. Sappey-Marinier</span> </a> (1, 5) </div> <button type="button" class="btn btn-hide-show" data-selectOne="#authors-simplified" data-selectTwo="#authors-detailed">Afficher plus de détails</button> <div class="structures bg-beige"> <div> <span class="icon-institution" aria-hidden="true"></span> </div> <div> <span>1</span> <a type="button" data-toggle="popover" class="btn-popover no-hide close-outside" data-container="body" data-placement="right" data-title="" data-content="<div class='popover-structure'><a href='/search/index/q/*/structId_i/139739' target='_blank'>CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé</a><small> (7 avenue Jean Capelle, Bat Blaise Pascal, 69621 Villeurbanne Cedex - France)</small> <label class='label label-primary label-VALID'>139739</label><ul><li><a href='/search/index/q/*/structId_i/194495' target='_blank'>UCBL - Université Claude Bernard Lyon 1</a><small> (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)</small> <label class='label label-primary label-VALID'>194495</label><ul><li><a href='/search/index/q/*/structId_i/301088' target='_blank'>Université de Lyon</a><small> (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)</small> <label class='label label-primary label-VALID'>301088</label></li></ul></li><li><a href='/search/index/q/*/structId_i/219748' target='_blank'>INSA Lyon - Institut National des Sciences Appliquées de Lyon</a><small> (20 Avenue Albert Einstein, 69621 Villeurbanne cedex - France)</small> <label class='label label-primary label-VALID'>219748</label><ul><li><a href='/search/index/q/*/structId_i/301088' target='_blank'>Université de Lyon</a><small> (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)</small> <label class='label label-primary label-VALID'>301088</label></li><li><a href='/search/index/q/*/structId_i/301232' target='_blank'>INSA - Institut National des Sciences Appliquées</a><small> (France)</small> <label class='label label-primary label-VALID'>301232</label></li></ul></li><li><a href='/search/index/q/*/structId_i/300284' target='_blank'>UJM - Université Jean Monnet - Saint-Étienne</a><small> (10, Rue Tréfilerie – CS 82301 42023 Saint-Étienne Cedex 2 - France)</small> <label class='label label-primary label-VALID'>300284</label></li><li><a href='/search/index/q/*/structId_i/303623' target='_blank'>INSERM - Institut National de la Santé et de la Recherche Médicale</a> : U1206<small> (101, rue de Tolbiac, 75013 Paris - France)</small> <label class='label label-primary label-VALID'>303623</label></li><li><a href='/search/index/q/*/structId_i/441569' target='_blank'>CNRS - Centre National de la Recherche Scientifique</a> : UMR5220<small> (France)</small> <label class='label label-primary label-VALID'>441569</label></li></ul></div>"> CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé </a> <br> <span>2</span> <a type="button" data-toggle="popover" class="btn-popover no-hide close-outside" data-container="body" data-placement="right" data-title="" data-content="<div class='popover-structure'><a href='/search/index/q/*/structId_i/103704' target='_blank'>UniCal - Università della Calabria [Arcavacata di Rende, Italia] = University of Calabria [Italy] = Université de Calabre [Italie]</a><small> (Campus di Arcavacata via Pietro Bucci 87036 Arcavacata di Rende (CS) - Italie)</small> <label class='label label-primary label-VALID'>103704</label></div>"> UniCal - Università della Calabria [Arcavacata di Rende, Italia] = University of Calabria [Italy] = Université de Calabre [Italie] </a> <br> <span>3</span> <a type="button" data-toggle="popover" class="btn-popover no-hide close-outside" data-container="body" data-placement="right" data-title="" data-content="<div class='popover-structure'><a href='/search/index/q/*/structId_i/530749' target='_blank'>RMN et optique : De la mesure au biomarqueur</a><small> (France)</small> <label class='label label-primary label-VALID'>530749</label><ul><li><a href='/search/index/q/*/structId_i/139739' target='_blank'>CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé</a><small> (7 avenue Jean Capelle, Bat Blaise Pascal, 69621 Villeurbanne Cedex - France)</small> <label class='label label-primary label-VALID'>139739</label><ul><li><a href='/search/index/q/*/structId_i/194495' target='_blank'>UCBL - Université Claude Bernard Lyon 1</a><small> (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)</small> <label class='label label-primary label-VALID'>194495</label><ul><li><a href='/search/index/q/*/structId_i/301088' target='_blank'>Université de Lyon</a><small> (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)</small> <label class='label label-primary label-VALID'>301088</label></li></ul></li><li><a href='/search/index/q/*/structId_i/219748' target='_blank'>INSA Lyon - Institut National des Sciences Appliquées de Lyon</a><small> (20 Avenue Albert Einstein, 69621 Villeurbanne cedex - France)</small> <label class='label label-primary label-VALID'>219748</label><ul><li><a href='/search/index/q/*/structId_i/301088' target='_blank'>Université de Lyon</a><small> (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)</small> <label class='label label-primary label-VALID'>301088</label></li><li><a href='/search/index/q/*/structId_i/301232' target='_blank'>INSA - Institut National des Sciences Appliquées</a><small> (France)</small> <label class='label label-primary label-VALID'>301232</label></li></ul></li><li><a href='/search/index/q/*/structId_i/300284' target='_blank'>UJM - Université Jean Monnet - Saint-Étienne</a><small> (10, Rue Tréfilerie – CS 82301 42023 Saint-Étienne Cedex 2 - France)</small> <label class='label label-primary label-VALID'>300284</label></li><li><a href='/search/index/q/*/structId_i/303623' target='_blank'>INSERM - Institut National de la Santé et de la Recherche Médicale</a> : U1206<small> (101, rue de Tolbiac, 75013 Paris - France)</small> <label class='label label-primary label-VALID'>303623</label></li><li><a href='/search/index/q/*/structId_i/441569' target='_blank'>CNRS - Centre National de la Recherche Scientifique</a> : UMR5220<small> (France)</small> <label class='label label-primary label-VALID'>441569</label></li></ul></li></ul></div>"> RMN et optique : De la mesure au biomarqueur </a> <br> <span>4</span> <a type="button" data-toggle="popover" class="btn-popover no-hide close-outside" data-container="body" data-placement="right" data-title="" data-content="<div class='popover-structure'><a href='/search/index/q/*/structId_i/300873' target='_blank'>Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL]</a><small> (59 Boulevard Pinel 69677 Bron cedex - France)</small> <label class='label label-primary label-VALID'>300873</label><ul><li><a href='/search/index/q/*/structId_i/300074' target='_blank'>HCL - Hospices Civils de Lyon</a><small> (3 Quai des Célestins 69002 Lyon - France)</small> <label class='label label-primary label-VALID'>300074</label></li></ul></div>"> Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] </a> <br> <span>5</span> <a type="button" data-toggle="popover" class="btn-popover no-hide close-outside" data-container="body" data-placement="right" data-title="" data-content="<div class='popover-structure'><a href='/search/index/q/*/structId_i/5460' target='_blank'>CERMEP - imagerie du vivant - Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant</a><small> (59 bd Pinel, 69677 BRON cedex - France)</small> <label class='label label-primary label-VALID'>5460</label><ul><li><a href='/search/index/q/*/structId_i/51335' target='_blank'>CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]</a><small> (42055 Saint Etienne cedex 2 - France)</small> <label class='label label-primary label-VALID'>51335</label></li><li><a href='/search/index/q/*/structId_i/194495' target='_blank'>UCBL - Université Claude Bernard Lyon 1</a><small> (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)</small> <label class='label label-primary label-VALID'>194495</label><ul><li><a href='/search/index/q/*/structId_i/301088' target='_blank'>Université de Lyon</a><small> (92 rue Pasteur - CS 30122, 69361 Lyon Cedex 07 - France)</small> <label class='label label-primary label-VALID'>301088</label></li></ul></li><li><a href='/search/index/q/*/structId_i/257328' target='_blank'>CHUGA - Centre Hospitalier Universitaire [CHU Grenoble]</a><small> (CS 10217 38043 Grenoble cedex 9 - France)</small> <label class='label label-primary label-VALID'>257328</label></li><li><a href='/search/index/q/*/structId_i/300074' target='_blank'>HCL - Hospices Civils de Lyon</a><small> (3 Quai des Célestins 69002 Lyon - France)</small> <label class='label label-primary label-VALID'>300074</label></li><li><a href='/search/index/q/*/structId_i/300284' target='_blank'>UJM - Université Jean Monnet - Saint-Étienne</a><small> (10, Rue Tréfilerie – CS 82301 42023 Saint-Étienne Cedex 2 - France)</small> <label class='label label-primary label-VALID'>300284</label></li><li><a href='/search/index/q/*/structId_i/303623' target='_blank'>INSERM - Institut National de la Santé et de la Recherche Médicale</a><small> (101, rue de Tolbiac, 75013 Paris - France)</small> <label class='label label-primary label-VALID'>303623</label></li><li><a href='/search/index/q/*/structId_i/441569' target='_blank'>CNRS - Centre National de la Recherche Scientifique</a><small> (France)</small> <label class='label label-primary label-VALID'>441569</label></li><li><a href='/search/index/q/*/structId_i/1042703' target='_blank'>UGA - Université Grenoble Alpes</a><small> (Adresse CS 40700 - 38058 Grenoble cedex - France)</small> <label class='label label-primary label-VALID'>1042703</label></li></ul></div>"> CERMEP - imagerie du vivant - Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant </a> <br> </div> </div> </div> <div id="authors-detailed"> <div class="container"> <div class="row"> <div class="col-lg-4"> <div class="bg-beige"> <a href="/search/index/q/*/authFullName_s/A.+Marzullo" target="_blank">A. Marzullo</a> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/139739">Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé</a> </div> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/103704">Università della Calabria [Arcavacata di Rende, Italia] = University of Calabria [Italy] = Université de Calabre [Italie]</a> </div> </div> </div> <div class="col-lg-4"> <div class="bg-beige"> <a href="/search/index/q/*/authIdHal_s/kocevar-gabriel" target="_blank">G. Kocevar</a> <ul> <li>Fonction : <strong>Auteur</strong></li> <li>PersonId : <strong>21385</strong></li> <li>IdHAL : <a href="/search/index/q/*/authIdHal_s/kocevar-gabriel" target="_blank" title="Consulter les publications"><strong>kocevar-gabriel</strong></a></li> <li>ORCID : <strong><a href="https://orcid.org/0000-0003-4130-6498" title="ORCID" target="_blank">0000-0003-4130-6498</a></strong></li> <li>IdRef : <strong><a href="https://www.idref.fr/203646177" title="IdRef" target="_blank">203646177</a></strong></li> </ul> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/139739">Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé</a> </div> </div> </div> <div class="col-lg-4"> <div class="bg-beige"> <a href="/search/index/q/*/authIdHal_i/1450697" target="_blank">C. Stamile</a> <ul> <li>Fonction : <strong>Auteur</strong></li> <li>PersonId : <strong>1450697</strong></li> <li>ORCID : <strong><a href="https://orcid.org/0000-0003-3291-2592" title="ORCID" target="_blank">0000-0003-3291-2592</a></strong></li> </ul> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/530749">RMN et optique : De la mesure au biomarqueur</a> </div> </div> </div> <div class="col-lg-4"> <div class="bg-beige"> <a href="/search/index/q/*/authIdHal_s/francoise-durand-dubief" target="_blank">F. Durand-Dubief</a> <ul> <li>Fonction : <strong>Auteur</strong></li> <li>PersonId : <strong>172702</strong></li> <li>IdHAL : <a href="/search/index/q/*/authIdHal_s/francoise-durand-dubief" target="_blank" title="Consulter les publications"><strong>francoise-durand-dubief</strong></a></li> <li>ORCID : <strong><a href="https://orcid.org/0000-0002-2860-1700" title="ORCID" target="_blank">0000-0002-2860-1700</a></strong></li> <li>IdRef : <strong><a href="https://www.idref.fr/15778911X" title="IdRef" target="_blank">15778911X</a></strong></li> </ul> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/300873">Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL]</a> </div> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/530749">RMN et optique : De la mesure au biomarqueur</a> </div> </div> </div> <div class="col-lg-4"> <div class="bg-beige"> <a href="/search/index/q/*/authFullName_s/G.+Terracina" target="_blank">G. Terracina</a> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/103704">Università della Calabria [Arcavacata di Rende, Italia] = University of Calabria [Italy] = Université de Calabre [Italie]</a> </div> </div> </div> <div class="col-lg-4"> <div class="bg-beige"> <a href="/search/index/q/*/authFullName_s/F.+Calimeri" target="_blank">F. Calimeri</a> <ul> <li>Fonction : <strong>Auteur</strong></li> </ul> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/103704">Università della Calabria [Arcavacata di Rende, Italia] = University of Calabria [Italy] = Université de Calabre [Italie]</a> </div> </div> </div> <div class="col-lg-4"> <div class="bg-beige"> <a href="/search/index/q/*/authIdHal_s/dominique-sappey-marinier" target="_blank">D. Sappey-Marinier</a> <ul> <li>Fonction : <strong>Auteur</strong></li> <li>PersonId : <strong>170664</strong></li> <li>IdHAL : <a href="/search/index/q/*/authIdHal_s/dominique-sappey-marinier" target="_blank" title="Consulter les publications"><strong>dominique-sappey-marinier</strong></a></li> <li>ORCID : <strong><a href="https://orcid.org/0000-0003-4104-1514" title="ORCID" target="_blank">0000-0003-4104-1514</a></strong></li> <li>IdRef : <strong><a href="https://www.idref.fr/033214344" title="IdRef" target="_blank">033214344</a></strong></li> </ul> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/139739">Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé</a> </div> <div class='detailed-affil'> <span class='icon-institution hal-icon'></span> <a href="/search/index/q/*/structId_i/5460">Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant</a> </div> </div> </div> </div> </div> <button type="button" class="btn btn-hide-show" data-selectOne="#authors-simplified" data-selectTwo="#authors-detailed" style="margin-top: 22px;">Réduire la vue détaillée</button> </div> <div class="row" style="width: 102%;"> <div class="abstract col-lg-7"> <div> <h4> Résumé </h4> <div class="btn-group" role="group" aria-label="Choix langues"> <button class="btn btn-lang-abstract active" aria-pressed="true" data-lang="en"> en </button> </div> </div> <div class="abstract-content active" lang="en"> Recent advances in image acquisition and processing techniques, along with the success of novel deep learning architectures, have given the opportunity to develop innovative algorithms capable to provide a better characterization of neurological related diseases. In this work, we introduce a neural network based approach to classify Multiple Sclerosis (MS) patients into four clinical profiles. Starting from their structural connectivity information, obtained by diffusion tensor imaging and represented as a graph, we evaluate the classification performances using unweighted and weighted connectivity matrices. Furthermore, we investigate the role of graph-based features for a better characterization and classification of the pathology. Ninety MS patients (12 clinically isolated syndrome, 30 relapsing-remitting, 28 secondary-progressive, and 20 primary-progressive) along with 24 healthy controls, were considered in this study. This work shows the great performances achieved by neural networks methods in the classification of the clinical profiles. Furthermore, it shows local graph metrics do not improve the classification results suggesting that the latent features created by the neural network in its layers have a much important informative content. Finally, we observe that graph weights representation of brain connections preserve important information to discriminate between clinical forms. </div> </div> <div class="col-lg-5"> <div class="keywords"> <div> <h4> Mots clés </h4> <div class="btn-group" role="group" aria-label="Choix langues" style="align-items: unset;"> <button class="btn btn-lang-keywords active" aria-pressed="true" data-lang="en"> en </button> </div> <div class="keys-lang en active" data-lang="en"> <span class="d-inline-block"> <a class="hal-bgtext" href="/search/index/q/*/keyword_t/connectome" target="_blank" rel="nofollow">connectome</a> </span> <span class="d-inline-block"> <a class="hal-bgtext" href="/search/index/q/*/keyword_t/diffusion%20tensor%20imaging" target="_blank" rel="nofollow">diffusion tensor imaging</a> </span> <span class="d-inline-block"> <a class="hal-bgtext" href="/search/index/q/*/keyword_t/graph%20neural%20networks" target="_blank" rel="nofollow">graph neural networks</a> </span> <span class="d-inline-block"> <a class="hal-bgtext" href="/search/index/q/*/keyword_t/graph-derived%20metrics" target="_blank" rel="nofollow">graph-derived metrics</a> </span> <span class="d-inline-block"> <a class="hal-bgtext" href="/search/index/q/*/keyword_t/multiple%20sclerosis" target="_blank" rel="nofollow">multiple sclerosis</a> </span> </div> </div> </div> <div class="domains"> <h4> Domaines </h4> <span class="d-inline-block"> <a class="hal-bgtext" href="/search/index/q/*/level0_domain_s/sdv" rel="nofollow" target="_blank">Sciences du Vivant [q-bio]</a> </span> <span class="d-inline-block"> <a class="hal-bgtext" href="/search/index/q/*/level1_domain_s/info.info-im" rel="nofollow" target="_blank">Imagerie médicale</a> </span> </div> <button data-toggle="modal" data-docid="4807451" data-target="#metadatas_Modal" aria-expanded="false" aria-controls="metadatas_Modal" class="btn hal-option-button metadatas" style="margin-top: 48px; width: 100%;"> Liste complète des métadonnées </button> <div class="modal fade" id="metadatas_Modal" data-backdrop=true tabindex="-1" aria-labelledby="metadatas_ModalLabel" aria-hidden="true" role="dialog"> <div class="modal-dialog" role="document"> <div class="modal-content"> <div class="modal-body" id="metadata-body" style="padding: 0;"></div> </div> </div> </div> </div> </div> <div class="viewer panel-doc d-none d-sm-block"> <button data-toggle="collapse" data-docid="4807451" data-target="#viewer-detailed" aria-expanded="true" aria-controls="viewer-detailed" class="btn drop-down"> Fichiers et aperçu <span class="icon-drop_down hal-icon" aria-hidden="true"></span> </button> <div id="viewer-detailed" class="panel-doc-detailed collapse show"> <div class="row"> <div class="col-md-2"> <div id="list-thumbnail-viewer" style="text-align: center;"> <span class='file-major'>Fichier principal</span> <div class="position-relative thumbnail-viewer active" data-id="4188157" data-preview="https://hal.science/hal-04649405v1/preview/main.pdf#page=2"> <img alt="Vignette du fichier" src="//thumb.ccsd.cnrs.fr/9567192/medium" style="width: 100%;"> </div> <span> main.pdf (3) </span> <a href="https://hal.science/hal-04649405v1/file/main.pdf" download="main.pdf"><span class="icon-download" aria-hidden="true"></span><span class="sr-only">Télécharger le fichier</span> </a> </div> </div> <div class="col-md-9 pb-4"> <div class="viewer-content active" id="4188157"> <iframe src="https://hal.science/hal-04649405v1/preview/main.pdf#page=2" allowfullscreen webkitallowfullscreen></iframe> <table class="table table-borderless"> <tbody> <tr> <th scope="row">Origine</th> <td> Publication financée par une institution </td> </tr> </tbody> </table> </div> </div> </div> </div> </div> </div> <div class="submitted-date d-none d-sm-block"> <p> <a rel="nofollow" href="/search/index/q/*/contributorId_i/678681" target="_blank">Dominique Sappey-Marinier</a>  : <a href='javascript:void(0);' onclick="$('#form-login').submit();">Connectez-vous pour contacter le contributeur</a> </p> <p>https://hal.science/hal-04649405</p> <p>Soumis le : mercredi 27 novembre 2024-15:52:23</p> <p>Dernière modification le : mercredi 15 janvier 2025-14:51:42</p> </div> </section> <section class="col-12 col-md-3 order-sm-1"> <div class="section-content section-shadow hal-visualize-button widget-files"> <a href="https://hal.science/hal-04649405v1/document" target="_blank"> <div class="file d-flex align-items-center justify-content-center"> <i class="icon-download hal-icon mr-4" aria-hidden="true"></i> <span>Télécharger pour visualiser</span> </div> </a> </div> <div class="section-content section-shadow"> <h3> Dates et versions</h3> <div class="bg-beige versions pt-1 pb-1"> <span>hal-04649405 ,</span> <span><a href="https://hal.science/hal-04649405v1"> version 1</a></span> <span>(27-11-2024)</span> </div> <h3 style="margin-top: 10px;"> Identifiants</h3> <div class="identifier-list"> <ul> <li> <span> HAL Id : </span> <span> hal-04649405 , version 1 </span> </li> <li> <span> DOI : </span> <span> <a href="https://dx.doi.org/10.3389/fnins.2019.00594" target="_blank"> 10.3389/fnins.2019.00594 </a> </span> </li> <li> <span> PUBMED : </span> <span> <a href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=31244599" target="_blank"> 31244599 </a> </span> </li> <li> <span> PUBMEDCENTRAL : </span> <span> <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581753" target="_blank"> PMC6581753 </a> </span> </li> </ul> </div> </div> <div class="section-content section-shadow"> <div style="display: flex; justify-content: space-between; align-items: center;"> <h3> Citer</h3> <button id="citation-button" class="hal-option-button" style="padding: 6px 12px;"><span class="icon-copy"></span></button> </div> <div class="bg-beige p-2" id="citation"> A. Marzullo, G. Kocevar, C. Stamile, F. Durand-Dubief, G. Terracina, et al.. Classification of Multiple Sclerosis Clinical Profiles via Graph Convolutional Neural Networks. <i>Frontiers in Neuroscience</i>, 2019, 13, pp.594. <a target="_blank" href="https://dx.doi.org/10.3389/fnins.2019.00594">⟨10.3389/fnins.2019.00594⟩</a>. <a target="_blank" href="https://hal.science/hal-04649405v1">⟨hal-04649405⟩</a> </div> </div> <div class="section-content section-shadow section-export"> <h3> Exporter</h3> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="https://hal.science/hal-04649405v1/bibtex" target="_blank" style="white-space: nowrap;">BibTeX</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="https://hal.science/hal-04649405v1/tei" target="_blank" style="white-space: nowrap;">XML-TEI</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="https://hal.science/hal-04649405v1/dc" target="_blank" style="white-space: nowrap;">Dublin Core</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="https://hal.science/hal-04649405v1/dcterms" target="_blank" style="white-space: nowrap;">DC Terms</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="https://hal.science/hal-04649405v1/endnote" target="_blank" style="white-space: nowrap;">EndNote</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="https://hal.science/hal-04649405v1/datacite" target="_blank" style="white-space: nowrap;">DataCite</a> </span> </div> <div class="section-content section-shadow section-collection"> <h3> Collections</h3> <div> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="/INSERM" target="_blank"> INSERM</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="/UNIV-ST-ETIENNE" target="_blank"> UNIV-ST-ETIENNE</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="/HCL" target="_blank"> HCL</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="/UGA" target="_blank"> UGA</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="/CNRS" target="_blank"> CNRS</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="/UNIV-LYON1" target="_blank"> UNIV-LYON1</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="/INSA-LYON" target="_blank"> INSA-LYON</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="/CREATIS" target="_blank"> CREATIS</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="/INSA-GROUPE" target="_blank"> INSA-GROUPE</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="/UDL" target="_blank"> UDL</a> </span> <span class="d-inline-block"> <a class="hal-bgtext size-regular" href="/ANR" target="_blank"> ANR</a> </span> </div> </div> <div class="section-content section-shadow" id="metrics"> <div class="row"> <div class="metrics-views col-6"> <span> 43 </span> <span>Consultations</span> </div> <div class="metrics-views col-6"> <span> 6 </span> <span>Téléchargements</span> </div> </div> </div> <div class="section-content section-shadow section-collection"> <h3> Altmetric</h3> <script src="https://d1bxh8uas1mnw7.cloudfront.net/assets/embed.js"></script> <div data-badge-details="right" data-badge-type="donut" data-hide-no-mentions="false" class="altmetric-embed" data-doi="10.3389/fnins.2019.00594" ></div> </div> <div class="section-content section-shadow"> <h3> Partager</h3>   <div class="a2a_kit a2a_kit_size_32 a2a_default_style" > <a class="a2a_button_google_gmail"></a><span class="sr-only"> </span> <a class="a2a_button_mastodon"></a><span class="sr-only"> </span> <a class="a2a_button_facebook"></a><span class="sr-only"> </span> <a class="a2a_button_x"></a><span class="sr-only"> </span> <a class="a2a_button_linkedin"></a><span class="sr-only"> </span> <a class="a2a_dd" href="https://www.addtoany.com/share"></a><span class="sr-only"> More </span> </div>  <script async src="https://static.addtoany.com/menu/page.js"></script>  </div> </section> </section> <script type="text/javascript"> $(function () { linkifyElem ('.linkify'); 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Classification of Multiple Sclerosis Clinical Profiles via Graph Convolutional Neural Networks - ANR - Agence nationale de la recherche