CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="120"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "publications.waset.org",cType: 'non-interactive',cRay: '9135b716ada7ce6a',cH: '7jp73zym1hFQRyLVLnUl_QTrcfqqXt4qw6_Xqoa1cug-1739794655-1.2.1.1-EWYDqNqcvqVCq5Bp6nBgf7g7aK0ieP4oxW.2_zvk4hkSxadd7U.W_vg572rkWTuf',cUPMDTk: "\/abstracts\/60838\/identification-synthesis-and-biological-evaluation-of-the-major-human-metabolite-of-nlrp3-inflammasome-inhibitor-mcc950?__cf_chl_tk=ple.5jej2jXZIX8z8WIbhjG6RqaUNawfxP7M03HvpOg-1739794655-1.0.1.1-YPPjoE9Lik8ZwTArf2E7qpGB3Z0K_1ygztUHTjD6Fkc",cFPWv: 'b',cITimeS: '1739794655',cTTimeMs: '1000',cMTimeMs: '120000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/abstracts\/60838\/identification-synthesis-and-biological-evaluation-of-the-major-human-metabolite-of-nlrp3-inflammasome-inhibitor-mcc950?__cf_chl_f_tk=ple.5jej2jXZIX8z8WIbhjG6RqaUNawfxP7M03HvpOg-1739794655-1.0.1.1-YPPjoE9Lik8ZwTArf2E7qpGB3Z0K_1ygztUHTjD6Fkc",md: "3LDF1WvSO_RJIF74YPyLhI3xuO2bX58iTbENuHj_J8U-1739794655-1.2.1.1-C1wg36Rch2ZQcpvz2HVm_AGYqRhgnG.H4Hm6EMI6a8kQtMl6DHuENWNg1pTyjeJWhEbTykCCwoKie7fy33Sqizm7fuYkTb9GTyhFgLlLosHrQQbKYV8QZHY6Aic1SFuHb7yFikNTtDj5ZYiu3asbwj.rGkc.Z4SVkURqwkl8fZNZKt60m6XrdnQ_dKnO.prV0GdonHVAjMTHgFtjWb5t1upx3O2oEfV9qjR5aVCGQi8O8jGP5RyFCJKPuTLXtcd3zgn8zh3vsnmY2YfM1z25aRfdcY1CI7VHkwCgu4Gaqz9M0m0mB8KMw_n_wf0VwSzWDmjD243BxJ05vz0LFvVT2TM.CZ5EkC_6agc_CoJhwOLb5zKlTv.opUkpZ.iZ.XiJs0JX6nr55dBo6sBnaxdzAipoJuDarmxc4PT9yy3gtW9SM6tVhVWTzE1bIXccuBh186qqgcCXBRZURkQ.quuNRPHC0oDgRoFbtKnlsAVyuCTcTSICgD37J.IY9uJUyLu5c6qgQ.OO67Y8J_gbiCnQ5JTUu9zTcwxPLKytpzirHo4dCpbrBc6THwfRJuIqbLWmz6CkiPGU4wOuDC5ZtYh2Fuowj7v2bOw3OuJn1ISMSgMvmDMqrIgg2THpYPajc48OvgTmWxKJeCKeL5hbMRD6cncAkkj8I.kgW0Kg7c3BaXxzW5t12vqpReoMAfyTx0FckS2GtK9xHPbMG043NTDgWvRF3EteYyL.vlb9dGNx4ffaPKGdUyqe5uYeRrS_9epUX9QxMRV2s0RDBiHqMvoyM2P24OGlpV96_wCjbZNzsbm4cah58HTyQneCP0_OJjRvlPNGsio9dUqQnPHVycaGiFKMrhM6EkarA3n4d6rS1xcgVvMca8cAC1znmyeQ1Y1EJnrf1CWRaksXL7V3CXnJws0ljDpW0ufSZwo5MM1apf7ShVc7C_oEzxh6o0o5rxs7bXIzQ5b3HqrHkXtsCdRMrdufe0sSz45lYuQJQQI3U..r6y9mMZMzW8sBmfBNJ2xEt72JV1oHwVXkQdxbIDcUMOPIs3_jff8bYHO0XPK0dsuYzfWKF6frapDqCtlLwUKKufkzmKnNGu7tz4U1.Z4lxUpq.6thglpZKCxu2y23nKabdZoMlckoA_ZjqJnE2i5k9HceoNUVCYBSTBuGoMw3GiFznmLyBCQbxU1CewvFPAghhdtJHDPPYPEKpyNMYBMl.hYb1odFAECSgmszTI0ECf9GYUBzvS2Ghxvn1m.u1.R2PvMsAkIVVCBqlePYv4VMNuayRufwPUY7kCG_UH9hyBKStJLtCowlvMD692gyfHdOvGCwKEXOVHln2kL2XZyUQRUs1N5M1PNYbTiFJUTArRpZAOg.AjsOWfLA9bg.MeFnSXASScuWY9Fn2Yoe0od4cSm7Q6VFksePGSsdSYtd83je95GRhBUhhECYCRE2h1Yt5KKUWLnoCD.nlLQ.AdkgFduaaLuplOWWdxB75qJJUgOXWjuI5pYy8WekOww4guLmtk0Kb_H.VtFXFqaxu8JF1rF6x21J1ex1yxeZius5OgQ9DYPn6vuqQCNPKBB4Mz4WNq_CPOyehX25OSUcEydCZHfniLaUW6q7QzvwR3aE0DcG7fGN5Esz3pIcdLu5YL.oVgZg.FqXpx2ae6BmgHYKfPejq.2WAUpXZH882tNvn.iFfg..KPqPuMuurKz2bn_yvIZErs5zznJ.ghvvR9MwKWcda97qJ5nbbhPUpnISjYBrWitxRP6kBS.d2iIa51emb6g3KnZSPHz_uzbD7MkDGhqDYrz1TESpptY6MKaOzIqpcRisBJEWL_OBLhyc47HBfvXAXm1.zvZZ2dkl_hwNa0F14tFiieOuONmbnvSfQyc7wp1gmmIIXkyLzIkstMn1mcMWsyykLGTd1pHDwmjwrSJFWsocUeZgKcKruUPz6fobKpQX0Jm1fjZm82Atu6fpMYUrIpYkVJ_dJzHZbVGGi_HHlT4gg7.F0rXAZhYCniZQyDXzcDUHxffjbyEAvQFwnWR5izbBH.R_CbUmmh0TXA8ElcHqNb60DP740BSra2j_M.L7YWHXKyIVAG4uQT..lOL1iY5MThyhC1.I2lUUs9XVpQ9Hzn153mN4Hm9McnxG3epXyE_Ik6OG4bT4BgGAWxiUej.vehRxzcv6PmM8eWYzeFV9sXq.UZC5Lcgcb.rGy1Iwx9p_mLbl6p1r4nk",mdrd: "5nC12nuEYRAozGLmeNEqeTXy0.EX_vkhs.JFdjwGg.g-1739794655-1.2.1.1-40g4HAQCheLKhLzESPjYnVU7EHHrFBEL7rK1xfjva7ge7P758AfTtsqFbpQXwUkQmc53VWxxcKuYx3Rw6MntcuvVkuO1dsz3WRGodtYLY9MUWgcSd6CVa6boG7MA_x8PNyRoMIeiv03rBmzVIgFXA97e1Zd5Os9J67mt5mx1We6IOauOKGu9IvT0KJ2UH_0kC72it4lal5XfttcKHz8YzQqjzGUfJaLwKsd9piYlVglCwfRNLwwhfkkyIBGuzi6CVynVL2RtswsUXhRNqYAbWhPMRQ9LBLKA5DD_5XOgGS6k93E.xvwSOr5YSt9Aex_4VxKzmiRLS39xImK8TifYsG514pP5CHKbcxtHzCbyVAqx0v7Zgkia9sruqyrb25xByNQTMZ9ATauQP.K4F315ztj0m9mjac61T7MxHJCumD7SmFGmde1RAZAYtHHlpRYGfedLOKsj7TjT7GdRCcMaXbJnjG1RuRYiC9QD9c.LfRNpS7uWje5CfMCBwqA4crovEtP1HwXgIS6priO.tp2fAwc4FllnlkXMUPe8r82xy00B9jiEWLwWE0JNLFqNr9BcBq9LxvJWiTkz1l6YYtZAKY_AGsF1pngxpZMDzfRQ7gFb4tZuaxL0s3nF6klZ7e3QdtZO_x6862.5K1vIdQvZlOLg1ymlt3A9QbCQf7vussqhvOxsxp9eCfV7u0F9hbzRf5TQoMoo1fcx1t2YwL7UnDpqc.0OE2gLlwEJ20D81lDccXqw4IIrYtuoraHGOdATJBc2DPffwA7GS6hiJrfs4qNyWpJ4pfOPi4V98SaH.HtN4qRjNrgHmXw2Qi8d.gtteu_DkcViwtTZEZvTlZqzsYJI7yuyuiNd_DmGFtYjpi7TefzApd2F6f6r_XXcqDmKHujc8vuyY3cb1t_7l0_TU74OW7vP0UU0bu70A6LIH70noMcblXz_fhlesqVtMfWCWPm4mfOWycrxjEc2taYqMfIPJAzXM0Fho61hIugpj1LETcTkPcEqFfKEmXckLl6ZtxaGkZZ8H5tbe.POuC4OinsAiv8FbM31nDJnasLHyez5N0Eoz7bhXW3An8Qpn6gNSCR3NFSy0aGcrxRn9GoHzwSzpGfxPbhEVQOxMWM.2QjuriJayRfWhIuc0fo6diVHH2fqr21kOHolImomQw.tt3x4UkjGJgPAYs2.Lfip51.YLrB849a83S5duD5eRBPP6xv2LVbgXmrJkBHm3ANTNuylmT5uTr1QomFsQzDprGIDsybMbldRF90xy4IgwAJX_LiL6wGqz_TGFPmatq5FEouZHppVWjs4Dasm9rxAt0eU5gbu8Rl7pl4d.S.yrWfPDznW4asildKOcKzJjOMnp0MDg2qC03WWMtG.Vg34e.bENfCpIsZF1iggiwv6j2FSgTn0TX24lPeGddqMkFpX_54nTBsSNdqzOc6IRrGw8A9HmjhRx96I9ZWCLqAkUUzHwJlj5ty1vs1_P8XLtA0wpAJ5fEtcrihzFxAFPtcRv6IHU1DPYHhjeiLcogoey6GVs.Sz5.54rVCOlO5s6hxVBUs2ky2V98O1OKBraFkNZkZdUq4BJpPu_CDZq7W4cLnbl1gDZKSCslDaza5xRE8LhOY_0ULulBY2x9_IdkmlVqEs9EPM5sNdg.mLm3SJTGibRO2_kXcNu7c71gzUZ3WOMFt__FdvdT2PtVMZ8JEPHlN4e0uo6WHlIklFPg813fvaGcS9O7ouEkC6VOG6HIV1ZXiviEEZxfN.zqj4C3skL3IjS4YD6WbEYSytafehuC2k0neSZWPB6iKuFY2DIaQPjBg3w8sYJQDQZ.7iNbJBbRGn.Qrr.I_kM1Rje67_rXWdTREWGVGSzN.xE6dT.hnN7pok3COLfKCiialVBKh.abTdpvW9hTkTjv2g6bia56PGBg75K17S8DEAYsWZkZM0RHfmXUs2VHvbwd_5sBfxhyy9256J98WogzS2yjzFM03g"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=9135b716ada7ce6a';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/abstracts\/60838\/identification-synthesis-and-biological-evaluation-of-the-major-human-metabolite-of-nlrp3-inflammasome-inhibitor-mcc950?__cf_chl_rt_tk=ple.5jej2jXZIX8z8WIbhjG6RqaUNawfxP7M03HvpOg-1739794655-1.0.1.1-YPPjoE9Lik8ZwTArf2E7qpGB3Z0K_1ygztUHTjD6Fkc" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>