Effects of Treatment on Morbidity in Hypertension: Results in Patients With Diastolic Blood Pressures Averaging 115 Through 129 mm Hg | JAMA

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Twenty-seven severe, complicating events..." /> <meta property="fb:pages" content="87087958340" /> <meta property="fb:pages" content="122228711814384" /> <meta property="fb:pages" content="1648414928738217" /> <meta property="fb:pages" content="117506346528" /> <meta property="fb:pages" content="97538728726" /> <meta property="fb:pages" content="114116793520" /> <meta property="fb:pages" content="100679858757" /> <meta property="fb:pages" content="759822190741773" /> <meta property="fb:pages" content="100265333750" /> <meta property="fb:pages" content="234770525256" /> <meta property="fb:pages" content="98784919862" /> <meta property="fb:pages" content="120829458202" /> <meta property="fb:pages" content="124842870398" /> <meta property="fb:pages" content="110245330325636" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:site" content="@JAMA_current" /> <meta name="twitter:image" content="https://cdn.jamanetwork.com/images/logos/JAMA.png" /> <meta name="citation_title" content="Effects of Treatment on Morbidity in Hypertension: Results in Patients With Diastolic Blood Pressures Averaging 115 Through 129 mm Hg" /><meta name="citation_firstpage" content="1028" /><meta name="citation_lastpage" content="1034" /><meta name="citation_doi" content="10.1001/jama.1967.03130240070013" /><meta name="citation_abstract" content="<p>A group of 143 male hypertensive patients with diastolic blood pressures (at the clinic) averaging between 115 and 129 mm Hg were randomly assigned to either active (hydrochlorothiazide plus reserpine plus hydralazine hydrochloride) or placebo treatment. Twenty-seven severe, complicating events developed in the placebotreated patients as compared to two in the active group. Four deaths occurred in the placebo-treated group and none in the actively treated patients. Other complications in the placebo group included grade 3 or 4 hypertensive retinopathy, congestive heart failure, increasing azotemia, cerebrovascular thrombosis, transient ischemic attacks, cerebral hemorrhage, myocardial infarction, and severely elevated blood pressure. Severe complications in the active-treatment group were one cerebrovascular thrombosis and one case of multiple drug toxicity. Male patients with diastolic blood pressures averaging 115 mm Hg or above represent a high-risk group in which antihypertensive therapy exerts a significant beneficial effect.</p>" /><meta name="citation_journal_title" content="JAMA" /><meta name="citation_journal_abbrev" content="JAMA" /><meta name="citation_volume" content="202" /><meta name="citation_issue" content="11" /><meta name="citation_publication_date" content="1967/12/11" /><meta name="citation_issn" content="0098-7484" /><meta name="citation_publisher" content="American Medical Association" /><meta name="citation_reference" content="citation_title=The Effect of Treatment on Mortality Rates in Severe Hypertension. A Comparison of Medical and Surgical Regimens; citation_author=Perry , H.M. Jr., and Schroeder, H.A.; citation_journal_title=Arch Int Med; citation_year=1958; citation_volume=102; citation_issue=Sept; citation_pages=418-425 (; " /><meta name="citation_reference" content="citation_title=The Effectiveness of Long-Term Treatment of Malignant Hypertension; citation_author=Dustan , H.P., et al; citation_journal_title=Circulation; citation_year=1958; citation_volume=18; citation_issue=Oct; citation_pages=644-651 (; " /><meta name="citation_reference" content="citation_title=Results of Treatment in Malignant Hypertension; citation_author=Harrington , M.; Kincaid-Smith, P.; and McMichael, J.; citation_journal_title=Brit Med J; citation_year=1959; citation_volume=2; citation_issue=Nov 14; citation_pages=969-980 (; " /><meta name="citation_reference" content="citation_title=Five-Year Survival of Consecutive Patients With Malignant Hypertension Treated With Antihypertensive Agents; citation_author=Sokolow , M., and Perloff, D.; citation_journal_title=Amer J Cardiol; citation_year=1960; citation_volume=6; citation_issue=Nov; citation_pages=858-863 (; " /><meta name="citation_reference" content="citation_title=The Effect of Active Drug Treatment in Severe Hypertensive Disease; citation_author=Björk , S., et al; citation_journal_title=Acta Med Scand; citation_year=1961; citation_volume=169; citation_issue=June; citation_pages=673-689 (; " /><meta name="citation_reference" content="citation_title=Five-Year Survival of Patients With Malignant Hypertension Treated With Antihypertensive Agents; citation_author=Mohler , E.R., and Freis, E.D.; citation_journal_title=Amer Heart J; citation_year=1960; citation_volume=60; citation_issue=Sept; citation_pages=329-335 (; " /><meta name="citation_reference" content="citation_title=Antihypertensive Drug Versus Symptomatic Treatment in Primary Hypertension: Effect on Survival; citation_author=Perera , G.A.; citation_journal_title=JAMA; citation_year=1960; citation_volume=173; citation_issue=May 7; citation_pages=11-13 (; " /><meta name="citation_reference" content="citation_title=Antihypertensive Drug Therapy: An Appraisal; citation_author=Goldring , W., and Chasis, H.; citation_journal_title=Arch Int Med; citation_year=1965; citation_volume=115; citation_issue=May; citation_pages=523-525 (; " /><meta name="citation_reference" content="citation_author=Relman , A.S.: in Ingelfinger, F.J.; Relman, A.S.; and Finland, M. 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(ed.); citation_title=Antihypertensive Therapy; Principles and Practice, an International Symposium, New York; citation_year=1966; citation_pages=196-211; " /><meta name="citation_reference" content="citation_title=Double Blind Control Study of Antihypertensive Agents: III. 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data-value="December 11, 1967" data-type="string"></span> <span class="hide tagmanagervalue" data-attribute="category" data-value="Research" data-type="string"></span> <span class="hide tagmanagervalue" data-attribute="journalClub" data-value="No" data-type="string"></span> <span class="hide tagmanagervalue" data-attribute="contentStatus" data-value="Locked" data-type="string"></span> <span class="hide tagmanagervalue" data-attribute="articlePubState" data-value="Final" data-type="string"></span> <span class="hide tagmanagervalue" data-attribute="contentMedium" data-value="Article" data-type="string"></span> <div class="meta-article-type-wrap"> <div class="meta-article-type thm-col">Article </div> </div> <div class="meta-date"><span class="ppub"><span class="month">December </span><span class="day">11, </span><span class="year">1967</span></span></div> <div class="meta-article-title-wrap"> <h1 class="meta-article-title ">Effects of Treatment on Morbidity in Hypertension<span class="subtitle"><span class="colon-for-citation-subtitle">: </span>Results in Patients With Diastolic Blood Pressures Averaging 115 Through 129 mm Hg</span></h1> </div> <div class="meta-citation-wrap"> <span class="meta-citation-journal-name">JAMA. </span><span class="meta-citation"> 1967;202(11):1028-1034. doi:10.1001/jama.1967.03130240070013</span> </div> </div> <div class="widget-EditorsChoice widget-instance-AMA_EditorsChoice_Links"> <div class="sm-linked-content"> <div class="sm-linked-content--item"> <a href="https://sites.jamanetwork.com/jnc8/" target="_blank" class="sm-linked-content--link fw-b sb-tc"><i class="icon-url d-ib thm-col"></i>Hypertension Guidelines Website</a> </div> </div> </div> <div class="widget-LinkedContentToolbar widget-instance-AMA_LinkedContentToolbar"> <div class="linked-content-toolbar"> <div class="hidden js-search-open-multimedia-by-default" showContentByDefault="False"></div> <div class="linked-content-controls"> <a class="linked-content-trigger td-n 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Twenty-seven severe, complicating events developed in the placebotreated patients as compared to two in the active group. Four deaths occurred in the placebo-treated group and none in the actively treated patients. Other complications in the placebo group included grade 3 or 4 hypertensive retinopathy, congestive heart failure, increasing azotemia, cerebrovascular thrombosis, transient ischemic attacks, cerebral hemorrhage, myocardial infarction, and severely elevated blood pressure. Severe complications in the active-treatment group were one cerebrovascular thrombosis and one case of multiple drug toxicity. 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Effects of Treatment on Morbidity in Hypertension: Results in Patients With Diastolic Blood Pressures Averaging 115 Through 129 mm Hg | JAMA | JAMA Network