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</a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Daniel Sander Hoffmann</h3></div><div class="js-work-strip profile--work_container" data-work-id="106398083"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/106398083/Prophylaxis_in_Hemophilia"><img alt="Research paper thumbnail of Prophylaxis in Hemophilia" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/106398083/Prophylaxis_in_Hemophilia">Prophylaxis in Hemophilia</a></div><div class="wp-workCard_item"><span>Clinical &amp; Biomedical Research</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Hemophilia is an inherited X-linked coagulopathy defined by a deficiency or abnormality in the cl...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Hemophilia is an inherited X-linked coagulopathy defined by a deficiency or abnormality in the clotting function of factor VIII (Hemophilia A) or factor IX (Hemophilia B). Prophylaxis – the regular administration of therapeutic products to maintain hemostasis and prevent bleeding – is the mainstream of treatment. Addressing the development and scientific evidence for administrating prophylaxis is the goal of this review. Prophylaxis is the therapeutic modality of choice for people with severe hemophilia, being considered, in principle, a lifelong treatment. It should have an early onset, ideally as a primary, or at least secondary. Even lifelong tertiary prophylaxis seems to offer benefit, although further studies are still lacking. Individualized strategies should lead to an optimization of the dilemma between better joint outcomes versus involved costs.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="106398083"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="106398083"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 106398083; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=106398083]").text(description); $(".js-view-count[data-work-id=106398083]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 106398083; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='106398083']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 106398083, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=106398083]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":106398083,"title":"Prophylaxis in Hemophilia","translated_title":"","metadata":{"abstract":"Hemophilia is an inherited X-linked coagulopathy defined by a deficiency or abnormality in the clotting function of factor VIII (Hemophilia A) or factor IX (Hemophilia B). 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data-click-track="profile-work-strip-title" href="https://www.academia.edu/106398082/Big_Data_and_Deep_Learning_Models">Big Data and Deep Learning Models</a></div><div class="wp-workCard_item"><span>Principia: An International Journal of Epistemology</span><span>, Dec 13, 2022</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2a93c28cd12cd5dd9386a0a71e7d0e54" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105606458,"asset_id":106398082,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105606458/download_file?st=MTczMjQ1ODc1OCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper 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"profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="106398077"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/106398077/Entrevista_Conversando_com_Bernd_Olaf_K%C3%BCppers"><img alt="Research paper thumbnail of Entrevista: Conversando com Bernd-Olaf Küppers" class="work-thumbnail" src="https://attachments.academia-assets.com/105606453/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/106398077/Entrevista_Conversando_com_Bernd_Olaf_K%C3%BCppers">Entrevista: Conversando com Bernd-Olaf Küppers</a></div><div class="wp-workCard_item"><span>Zenodo (CERN European Organization for Nuclear Research)</span><span>, Dec 1, 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dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="78047065"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/78047065/Epidemiological_characteristics_of_hemophilia_in_the_pre_primary_prophylaxis_era_a_historical_cohort"><img alt="Research paper thumbnail of Epidemiological characteristics of hemophilia in the pre-primary prophylaxis era: a historical cohort" class="work-thumbnail" src="https://attachments.academia-assets.com/85229987/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/78047065/Epidemiological_characteristics_of_hemophilia_in_the_pre_primary_prophylaxis_era_a_historical_cohort">Epidemiological characteristics of hemophilia in the pre-primary prophylaxis era: a historical cohort</a></div><div class="wp-workCard_item"><span>Clinical & Biomedical Research</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Introduction: Epidemiological studies on hemophilia in the Brazilian population are historically ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Introduction: Epidemiological studies on hemophilia in the Brazilian population are historically scarce. Despite the continuous effort made by the National Program of Inherited Bleeding Disorders to map this condition, little information is available, especially on the period prior to program conception. Therefore, the present study aims to assess the epidemiological, serological, and clinical characteristics of patients with hemophilia in the state of Rio Grande do Sul, Brazil. Methods: A total of 455 patients had their medical records reviewed from January 1, 2003 to December 31, 2007. Results: We observed a remarkable prevalence of hepatitis C virus (HCV) infection in patients with both hemophilia A and B, and this prevalence significantly increased along with age (p &lt; 0.001). No positive anti-HCV results were observed among children younger than 5 years old. There was a significant correlation between the severity of hemophilia and the number of arthropathies in all age categ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="16f1902dcc6cda0e783b6158fa38e145" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":85229987,"asset_id":78047065,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/85229987/download_file?st=MTczMjQ1ODc1OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="78047065"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="78047065"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78047065; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78047065]").text(description); $(".js-view-count[data-work-id=78047065]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78047065; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='78047065']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 78047065, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "16f1902dcc6cda0e783b6158fa38e145" } } $('.js-work-strip[data-work-id=78047065]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":78047065,"title":"Epidemiological characteristics of hemophilia in the pre-primary prophylaxis era: a historical cohort","translated_title":"","metadata":{"abstract":"Introduction: Epidemiological studies on hemophilia in the Brazilian population are historically scarce. Despite the continuous effort made by the National Program of Inherited Bleeding Disorders to map this condition, little information is available, especially on the period prior to program conception. Therefore, the present study aims to assess the epidemiological, serological, and clinical characteristics of patients with hemophilia in the state of Rio Grande do Sul, Brazil. Methods: A total of 455 patients had their medical records reviewed from January 1, 2003 to December 31, 2007. Results: We observed a remarkable prevalence of hepatitis C virus (HCV) infection in patients with both hemophilia A and B, and this prevalence significantly increased along with age (p \u0026lt; 0.001). No positive anti-HCV results were observed among children younger than 5 years old. There was a significant correlation between the severity of hemophilia and the number of arthropathies in all age categ...","publisher":"Clinical \u0026 Biomedical Research","publication_date":{"day":null,"month":null,"year":2021,"errors":{}},"publication_name":"Clinical \u0026 Biomedical Research"},"translated_abstract":"Introduction: Epidemiological studies on hemophilia in the Brazilian population are historically scarce. Despite the continuous effort made by the National Program of Inherited Bleeding Disorders to map this condition, little information is available, especially on the period prior to program conception. Therefore, the present study aims to assess the epidemiological, serological, and clinical characteristics of patients with hemophilia in the state of Rio Grande do Sul, Brazil. Methods: A total of 455 patients had their medical records reviewed from January 1, 2003 to December 31, 2007. Results: We observed a remarkable prevalence of hepatitis C virus (HCV) infection in patients with both hemophilia A and B, and this prevalence significantly increased along with age (p \u0026lt; 0.001). No positive anti-HCV results were observed among children younger than 5 years old. 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I also underline that the creation of the journal &quot;The Bulletin of Mathematical Biophysics&quot; was instrumental in legitimating the efforts of Rashevsky and his students, and I finally argue that his pioneering efforts, while still largely unacknowledged, were vital for the development of important scientific contributions, most notably the McCulloch-Pitts model of neural networks.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1c772cfe4c5eca8432622e6f1c4e3cf9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":85229916,"asset_id":78047064,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/85229916/download_file?st=MTczMjQ1ODc1OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="78047064"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="78047064"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78047064; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78047064]").text(description); $(".js-view-count[data-work-id=78047064]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78047064; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='78047064']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 78047064, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1c772cfe4c5eca8432622e6f1c4e3cf9" } } $('.js-work-strip[data-work-id=78047064]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":78047064,"title":"The dawn of mathematical biology","translated_title":"","metadata":{"abstract":"In this paper I describe the early development of the so-called mathematical biophysics, as conceived by Nicolas Rashevsky back in the 1920\u0026#39;s, as well as his latter idealization of a \u0026quot;relational biology\u0026quot;. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="78047063"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/78047063/Complexidade_e_organiza%C3%A7%C3%A3o_biol%C3%B3gica"><img alt="Research paper thumbnail of Complexidade e organização biológica" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/78047063/Complexidade_e_organiza%C3%A7%C3%A3o_biol%C3%B3gica">Complexidade e organização biológica</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A area de pesquisa conhecida como biologia relacional foi inaugurada por Nicolas Rashevsky, porem...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A area de pesquisa conhecida como biologia relacional foi inaugurada por Nicolas Rashevsky, porem foi largamente desenvolvida por Robert Rosen. Neste artigo eu apresento e discuto alguns dos pressupostos subjacentes a essa linha de investigacao, adotando a estrategia de focar apenas em alguns dos principais avancos propostos por Rosen, em particular aqueles vinculados as nocoes de complexidade e organizacao biologica. Enfatizo tambem o conceito de “fechamento causal” roseniano, devido a sua relacao proxima com a nocao de autopoiese de Maturana e Varela. Procuro desenvolver, da melhor forma possivel, uma investigacao imparcial, apontando tanto as virtudes quanto os pontos criticos dos topicos por mim selecionados a partir da vasta obra intelectual de Rosen.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="78047063"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="78047063"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78047063; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78047063]").text(description); $(".js-view-count[data-work-id=78047063]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78047063; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='78047063']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 78047063, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=78047063]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":78047063,"title":"Complexidade e organização biológica","translated_title":"","metadata":{"abstract":"A area de pesquisa conhecida como biologia relacional foi inaugurada por Nicolas Rashevsky, porem foi largamente desenvolvida por Robert Rosen. Neste artigo eu apresento e discuto alguns dos pressupostos subjacentes a essa linha de investigacao, adotando a estrategia de focar apenas em alguns dos principais avancos propostos por Rosen, em particular aqueles vinculados as nocoes de complexidade e organizacao biologica. Enfatizo tambem o conceito de “fechamento causal” roseniano, devido a sua relacao proxima com a nocao de autopoiese de Maturana e Varela. Procuro desenvolver, da melhor forma possivel, uma investigacao imparcial, apontando tanto as virtudes quanto os pontos criticos dos topicos por mim selecionados a partir da vasta obra intelectual de Rosen.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}}},"translated_abstract":"A area de pesquisa conhecida como biologia relacional foi inaugurada por Nicolas Rashevsky, porem foi largamente desenvolvida por Robert Rosen. Neste artigo eu apresento e discuto alguns dos pressupostos subjacentes a essa linha de investigacao, adotando a estrategia de focar apenas em alguns dos principais avancos propostos por Rosen, em particular aqueles vinculados as nocoes de complexidade e organizacao biologica. Enfatizo tambem o conceito de “fechamento causal” roseniano, devido a sua relacao proxima com a nocao de autopoiese de Maturana e Varela. Procuro desenvolver, da melhor forma possivel, uma investigacao imparcial, apontando tanto as virtudes quanto os pontos criticos dos topicos por mim selecionados a partir da vasta obra intelectual de Rosen.","internal_url":"https://www.academia.edu/78047063/Complexidade_e_organiza%C3%A7%C3%A3o_biol%C3%B3gica","translated_internal_url":"","created_at":"2022-04-30T07:19:19.057-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":28508546,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Complexidade_e_organização_biológica","translated_slug":"","page_count":null,"language":"pt","content_type":"Work","owner":{"id":28508546,"first_name":"Daniel","middle_initials":null,"last_name":"Sander Hoffmann","page_name":"DanielSanderHoffmann","domain_name":"independent","created_at":"2015-03-25T17:56:39.311-07:00","display_name":"Daniel Sander Hoffmann","url":"https://independent.academia.edu/DanielSanderHoffmann"},"attachments":[],"research_interests":[{"id":803,"name":"Philosophy","url":"https://www.academia.edu/Documents/in/Philosophy"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="78047062"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/78047062/The_dawn_of_mathematical_biology_A_aurora_da_biologia_matem%C3%A1tica"><img alt="Research paper thumbnail of The dawn of mathematical biology A aurora da biologia matemática" class="work-thumbnail" src="https://attachments.academia-assets.com/85229913/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/78047062/The_dawn_of_mathematical_biology_A_aurora_da_biologia_matem%C3%A1tica">The dawn of mathematical biology A aurora da biologia matemática</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In this paper I describe the early development of the so-called mathematical biophysics, as conce...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In this paper I describe the early development of the so-called mathematical biophysics, as conceived by Nicolas Rashevsky back in the 1920 ́s, as well as his latter idealization of a “relational biology”. I also underline that the creation of the journal The Bulletin of Mathematical Biophysics was instrumental in legitimating the efforts of Rashevsky and his students, and I finally argue that his pioneering efforts, while still largely unacknowledged, were vital for the development of important scientific contributions, most notably the McCulloch-Pitts model of neural networks.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="15be79f891e615df181749a72ff22900" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":85229913,"asset_id":78047062,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/85229913/download_file?st=MTczMjQ1ODc1OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="78047062"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="78047062"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78047062; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78047062]").text(description); $(".js-view-count[data-work-id=78047062]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78047062; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='78047062']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 78047062, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "15be79f891e615df181749a72ff22900" } } $('.js-work-strip[data-work-id=78047062]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":78047062,"title":"The dawn of mathematical biology A aurora da biologia matemática","translated_title":"","metadata":{"abstract":"In this paper I describe the early development of the so-called mathematical biophysics, as conceived by Nicolas Rashevsky back in the 1920 ́s, as well as his latter idealization of a “relational biology”. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="78046863"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/78046863/Simula%C3%A7%C3%A3o_De_Uma_Rede_Neural_Pulsada_Embarc%C3%A1vel_Em_Plataformas_Rob%C3%B3ticas_M%C3%B3veis"><img alt="Research paper thumbnail of Simulação De Uma Rede Neural Pulsada Embarcável Em Plataformas Robóticas Móveis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/78046863/Simula%C3%A7%C3%A3o_De_Uma_Rede_Neural_Pulsada_Embarc%C3%A1vel_Em_Plataformas_Rob%C3%B3ticas_M%C3%B3veis">Simulação De Uma Rede Neural Pulsada Embarcável Em Plataformas Robóticas Móveis</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">As redes neurais pulsadas (RNPs), ou redes de terceira geracao, sao redes neurais artificiais que...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">As redes neurais pulsadas (RNPs), ou redes de terceira geracao, sao redes neurais artificiais que se caracterizam por replicar com precisao as interacoes sinapticas dos neuronios biologicos e o momento exato de ocorrencia dos potenciais de acao, superando, conforme alguns especialistas, o poder computacional das redes contendo unidades com funcao de ativacao de limiar e sigmoide. Um importante desafio, porem, e a descoberta de regras eficientes de aprendizado, que tiram proveito dos atributos peculiares as RNPs ao mesmo tempo em que preservam a utilidade dos modelos tradicionalmente adotados. Os principais problemas verificados quando as RNPs se aproximam do nivel biologico de complexidade dizem respeito a escalabilidade e ao aumento do tempo de processamento, o que justifica a tendencia atual de modelagem de grandes RNPs em hardware. O trabalho tem por objetivo o desenvolvimento de uma RNP de arquitetura minimalista, buscando oferecer uma prova de principio no contexto de uma aplic...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="78046863"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="78046863"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78046863; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78046863]").text(description); $(".js-view-count[data-work-id=78046863]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78046863; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='78046863']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 78046863, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=78046863]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":78046863,"title":"Simulação De Uma Rede Neural Pulsada Embarcável Em Plataformas Robóticas Móveis","translated_title":"","metadata":{"abstract":"As redes neurais pulsadas (RNPs), ou redes de terceira geracao, sao redes neurais artificiais que se caracterizam por replicar com precisao as interacoes sinapticas dos neuronios biologicos e o momento exato de ocorrencia dos potenciais de acao, superando, conforme alguns especialistas, o poder computacional das redes contendo unidades com funcao de ativacao de limiar e sigmoide. 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O trabalho tem por objetivo o desenvolvimento de uma RNP de arquitetura minimalista, buscando oferecer uma prova de principio no contexto de uma aplic...","publication_date":{"day":null,"month":null,"year":2015,"errors":{}}},"translated_abstract":"As redes neurais pulsadas (RNPs), ou redes de terceira geracao, sao redes neurais artificiais que se caracterizam por replicar com precisao as interacoes sinapticas dos neuronios biologicos e o momento exato de ocorrencia dos potenciais de acao, superando, conforme alguns especialistas, o poder computacional das redes contendo unidades com funcao de ativacao de limiar e sigmoide. Um importante desafio, porem, e a descoberta de regras eficientes de aprendizado, que tiram proveito dos atributos peculiares as RNPs ao mesmo tempo em que preservam a utilidade dos modelos tradicionalmente adotados. Os principais problemas verificados quando as RNPs se aproximam do nivel biologico de complexidade dizem respeito a escalabilidade e ao aumento do tempo de processamento, o que justifica a tendencia atual de modelagem de grandes RNPs em hardware. 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Prophylaxis – the regular administration of therapeutic products to maintain hemostasis and prevent bleeding – is the mainstream of treatment. Addressing the development and scientific evidence for administrating prophylaxis is the goal of this review. Prophylaxis is the therapeutic modality of choice for people with severe hemophilia, being considered, in principle, a lifelong treatment. It should have an early onset, ideally as a primary, or at least secondary. Even lifelong tertiary prophylaxis seems to offer benefit, although further studies are still lacking. Individualized strategies should lead to an optimization of the dilemma between better joint outcomes versus involved costs.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="106398083"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="106398083"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 106398083; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=106398083]").text(description); $(".js-view-count[data-work-id=106398083]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 106398083; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='106398083']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 106398083, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=106398083]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":106398083,"title":"Prophylaxis in Hemophilia","translated_title":"","metadata":{"abstract":"Hemophilia is an inherited X-linked coagulopathy defined by a deficiency or abnormality in the clotting function of factor VIII (Hemophilia A) or factor IX (Hemophilia B). 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2001</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5d0e89eb95ba20a393b76112c7c9424a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":105606453,"asset_id":106398077,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/105606453/download_file?st=MTczMjQ1ODc1OSw4LjIyMi4yMDguMTQ2&st=MTczMjQ1ODc1OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="106398077"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span 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dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="78047065"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/78047065/Epidemiological_characteristics_of_hemophilia_in_the_pre_primary_prophylaxis_era_a_historical_cohort"><img alt="Research paper thumbnail of Epidemiological characteristics of hemophilia in the pre-primary prophylaxis era: a historical cohort" class="work-thumbnail" src="https://attachments.academia-assets.com/85229987/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/78047065/Epidemiological_characteristics_of_hemophilia_in_the_pre_primary_prophylaxis_era_a_historical_cohort">Epidemiological characteristics of hemophilia in the pre-primary prophylaxis era: a historical cohort</a></div><div class="wp-workCard_item"><span>Clinical & Biomedical Research</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Introduction: Epidemiological studies on hemophilia in the Brazilian population are historically ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Introduction: Epidemiological studies on hemophilia in the Brazilian population are historically scarce. Despite the continuous effort made by the National Program of Inherited Bleeding Disorders to map this condition, little information is available, especially on the period prior to program conception. Therefore, the present study aims to assess the epidemiological, serological, and clinical characteristics of patients with hemophilia in the state of Rio Grande do Sul, Brazil. Methods: A total of 455 patients had their medical records reviewed from January 1, 2003 to December 31, 2007. Results: We observed a remarkable prevalence of hepatitis C virus (HCV) infection in patients with both hemophilia A and B, and this prevalence significantly increased along with age (p &lt; 0.001). No positive anti-HCV results were observed among children younger than 5 years old. There was a significant correlation between the severity of hemophilia and the number of arthropathies in all age categ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="16f1902dcc6cda0e783b6158fa38e145" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":85229987,"asset_id":78047065,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/85229987/download_file?st=MTczMjQ1ODc1OSw4LjIyMi4yMDguMTQ2&st=MTczMjQ1ODc1OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="78047065"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="78047065"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78047065; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78047065]").text(description); $(".js-view-count[data-work-id=78047065]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78047065; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='78047065']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 78047065, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "16f1902dcc6cda0e783b6158fa38e145" } } $('.js-work-strip[data-work-id=78047065]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":78047065,"title":"Epidemiological characteristics of hemophilia in the pre-primary prophylaxis era: a historical cohort","translated_title":"","metadata":{"abstract":"Introduction: Epidemiological studies on hemophilia in the Brazilian population are historically scarce. Despite the continuous effort made by the National Program of Inherited Bleeding Disorders to map this condition, little information is available, especially on the period prior to program conception. Therefore, the present study aims to assess the epidemiological, serological, and clinical characteristics of patients with hemophilia in the state of Rio Grande do Sul, Brazil. Methods: A total of 455 patients had their medical records reviewed from January 1, 2003 to December 31, 2007. Results: We observed a remarkable prevalence of hepatitis C virus (HCV) infection in patients with both hemophilia A and B, and this prevalence significantly increased along with age (p \u0026lt; 0.001). No positive anti-HCV results were observed among children younger than 5 years old. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="78047064"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/78047064/The_dawn_of_mathematical_biology"><img alt="Research paper thumbnail of The dawn of mathematical biology" class="work-thumbnail" src="https://attachments.academia-assets.com/85229916/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/78047064/The_dawn_of_mathematical_biology">The dawn of mathematical biology</a></div><div class="wp-workCard_item"><span>arXiv: History and Philosophy of Physics</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In this paper I describe the early development of the so-called mathematical biophysics, as conce...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In this paper I describe the early development of the so-called mathematical biophysics, as conceived by Nicolas Rashevsky back in the 1920&#39;s, as well as his latter idealization of a &quot;relational biology&quot;. I also underline that the creation of the journal &quot;The Bulletin of Mathematical Biophysics&quot; was instrumental in legitimating the efforts of Rashevsky and his students, and I finally argue that his pioneering efforts, while still largely unacknowledged, were vital for the development of important scientific contributions, most notably the McCulloch-Pitts model of neural networks.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1c772cfe4c5eca8432622e6f1c4e3cf9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":85229916,"asset_id":78047064,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/85229916/download_file?st=MTczMjQ1ODc1OSw4LjIyMi4yMDguMTQ2&st=MTczMjQ1ODc1OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="78047064"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="78047064"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78047064; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78047064]").text(description); $(".js-view-count[data-work-id=78047064]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78047064; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='78047064']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 78047064, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1c772cfe4c5eca8432622e6f1c4e3cf9" } } $('.js-work-strip[data-work-id=78047064]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":78047064,"title":"The dawn of mathematical biology","translated_title":"","metadata":{"abstract":"In this paper I describe the early development of the so-called mathematical biophysics, as conceived by Nicolas Rashevsky back in the 1920\u0026#39;s, as well as his latter idealization of a \u0026quot;relational biology\u0026quot;. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="78047063"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/78047063/Complexidade_e_organiza%C3%A7%C3%A3o_biol%C3%B3gica"><img alt="Research paper thumbnail of Complexidade e organização biológica" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/78047063/Complexidade_e_organiza%C3%A7%C3%A3o_biol%C3%B3gica">Complexidade e organização biológica</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A area de pesquisa conhecida como biologia relacional foi inaugurada por Nicolas Rashevsky, porem...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A area de pesquisa conhecida como biologia relacional foi inaugurada por Nicolas Rashevsky, porem foi largamente desenvolvida por Robert Rosen. Neste artigo eu apresento e discuto alguns dos pressupostos subjacentes a essa linha de investigacao, adotando a estrategia de focar apenas em alguns dos principais avancos propostos por Rosen, em particular aqueles vinculados as nocoes de complexidade e organizacao biologica. Enfatizo tambem o conceito de “fechamento causal” roseniano, devido a sua relacao proxima com a nocao de autopoiese de Maturana e Varela. Procuro desenvolver, da melhor forma possivel, uma investigacao imparcial, apontando tanto as virtudes quanto os pontos criticos dos topicos por mim selecionados a partir da vasta obra intelectual de Rosen.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="78047063"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="78047063"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78047063; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78047063]").text(description); $(".js-view-count[data-work-id=78047063]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78047063; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='78047063']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 78047063, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=78047063]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":78047063,"title":"Complexidade e organização biológica","translated_title":"","metadata":{"abstract":"A area de pesquisa conhecida como biologia relacional foi inaugurada por Nicolas Rashevsky, porem foi largamente desenvolvida por Robert Rosen. 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Procuro desenvolver, da melhor forma possivel, uma investigacao imparcial, apontando tanto as virtudes quanto os pontos criticos dos topicos por mim selecionados a partir da vasta obra intelectual de Rosen.","internal_url":"https://www.academia.edu/78047063/Complexidade_e_organiza%C3%A7%C3%A3o_biol%C3%B3gica","translated_internal_url":"","created_at":"2022-04-30T07:19:19.057-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":28508546,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Complexidade_e_organização_biológica","translated_slug":"","page_count":null,"language":"pt","content_type":"Work","owner":{"id":28508546,"first_name":"Daniel","middle_initials":null,"last_name":"Sander Hoffmann","page_name":"DanielSanderHoffmann","domain_name":"independent","created_at":"2015-03-25T17:56:39.311-07:00","display_name":"Daniel Sander Hoffmann","url":"https://independent.academia.edu/DanielSanderHoffmann"},"attachments":[],"research_interests":[{"id":803,"name":"Philosophy","url":"https://www.academia.edu/Documents/in/Philosophy"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="78047062"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/78047062/The_dawn_of_mathematical_biology_A_aurora_da_biologia_matem%C3%A1tica"><img alt="Research paper thumbnail of The dawn of mathematical biology A aurora da biologia matemática" class="work-thumbnail" src="https://attachments.academia-assets.com/85229913/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/78047062/The_dawn_of_mathematical_biology_A_aurora_da_biologia_matem%C3%A1tica">The dawn of mathematical biology A aurora da biologia matemática</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In this paper I describe the early development of the so-called mathematical biophysics, as conce...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In this paper I describe the early development of the so-called mathematical biophysics, as conceived by Nicolas Rashevsky back in the 1920 ́s, as well as his latter idealization of a “relational biology”. I also underline that the creation of the journal The Bulletin of Mathematical Biophysics was instrumental in legitimating the efforts of Rashevsky and his students, and I finally argue that his pioneering efforts, while still largely unacknowledged, were vital for the development of important scientific contributions, most notably the McCulloch-Pitts model of neural networks.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="15be79f891e615df181749a72ff22900" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":85229913,"asset_id":78047062,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/85229913/download_file?st=MTczMjQ1ODc1OSw4LjIyMi4yMDguMTQ2&st=MTczMjQ1ODc1OSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="78047062"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="78047062"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 78047062; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=78047062]").text(description); $(".js-view-count[data-work-id=78047062]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 78047062; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='78047062']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 78047062, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "15be79f891e615df181749a72ff22900" } } $('.js-work-strip[data-work-id=78047062]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":78047062,"title":"The dawn of mathematical biology A aurora da biologia matemática","translated_title":"","metadata":{"abstract":"In this paper I describe the early development of the so-called mathematical biophysics, as conceived by Nicolas Rashevsky back in the 1920 ́s, as well as his latter idealization of a “relational biology”. 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