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You can also contact us with a list of preferred targets so we can build your own custom-panel.</p> </div> </div> </section> <section class="article"> <div class="contents-wrapper"> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <h3><strong>57 GPCR <span class="orange">Diversity Panel</span></strong></h3> <p><p>Profile the activity of your GPCR modulator over a broad panel representing the main receptor families. Compounds are tested for agonist and antagonist activities in functional assays favoring the natural coupling of each receptor, increasing the chances of picking up allosteric effects.</p> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <p><div class="table-wrapper"><table style="width: 100%; border-collapse: collapse;" border="1"> <tbody> <tr style="height: 25px;"> <td style="width: 16.74%; height: 25px; text-align: center;"><strong>Target</strong></td> <td style="width: 16.66%; height: 25px; text-align: center;"><strong>Natural coupling</strong></td> <td style="width: 16.58%; height: 25px; text-align: center;"><strong>Assay</strong></td> <td style="width: 16.66%; height: 25px; text-align: center;"><strong>Target</strong></td> <td style="width: 16.66%; height: 25px; text-align: center;"><strong>Natural coupling</strong></td> <td style="width: 16.58%; height: 25px; text-align: center;"><strong>Assay</strong></td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Serotonin 5-HT<sub>1A</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;" width="44">cAMP</td> <td style="width: 16.66%; text-align: center;" width="130">Leukotrien CysLT1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.58%; text-align: center;" width="44">AEQ</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Serotonin 5-HT<sub>1B</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="130">Dopamine D<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>olf, </sub>G<sub>s</sub></td> <td style="width: 16.58%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Serotonin 5-HT<sub>2A</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="130">Dopamine D<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Serotonin 5-HT<sub>2B</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="130">Dopamine D<sub>3</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Serotonin 5-HT<sub>2Cne</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Dopamine D<sub>4.4</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;" width="46">GTP纬S</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Serotonin 5-HT<sub>3</sub></td> <td style="width: 16.66%; text-align: center;" width="100">Ion channel</td> <td style="width: 16.58%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Endothelin ET<sub>A</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>s</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Serotonin 5-HT<sub>4e</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.58%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;">Endothelin ET<sub>B</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Serotonin 5-HT<sub>5a</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;">Ghrelin GHS-R</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Serotonin 5-HT<sub>6</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.58%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Histamine H<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Serotonin 5-HT<sub>7</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.58%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Histamine H<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.58%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Adenosine A<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Histamine H<sub>3</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Adenosine A<sub>2A</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.58%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Motilin MTL</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Adenosine A<sub>3</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Muscarinic M<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Adrenergic beta<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.58%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Muscarinic M<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Adrenergic beta<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.58%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Muscarinic M<sub>3</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Adrenergic聽 alpha<sub>1A</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Muscarinic M<sub>4</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Adrenergic聽 alpha<sub>1B</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Muscarinic M<sub>5</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Adrenergic聽 alpha<sub>2A</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">GTP纬S</td> <td style="width: 16.66%; text-align: center;" width="132">Nociceptin OFQ (NOP)</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Adrenergic聽 alpha<sub>2B</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">GTP纬S</td> <td style="width: 16.66%; text-align: center;" width="132">Neurokinin NK<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Adrenergic聽 alpha<sub>2C</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">GTP纬S</td> <td style="width: 16.66%; text-align: center;" width="132">Neurokinin NK<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Angiotensin AT<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;">Neuropeptide NPY<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Bradykinin B1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Opioid OP1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Cannabinoid CB<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Opioid OP2</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Cannabinoid CB<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Opioid OP3</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Cholecystokinin CCK<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>s</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Somatostatin sst<sub>4</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i</sub></td> <td style="width: 16.58%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.74%; text-align: center;" width="130">Cholecystokinin CCK<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Urotensin-II</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.74%; text-align: center;">Calcitonin CGRP</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>s</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;">Vasopressin V<sub>1a</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.74%; text-align: center;">Chemokine CXCR1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.58%; text-align: center;">GTP纬S</td> <td style="width: 16.66%; text-align: center;">Vasopressin V<sub>1b</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> </tr> <tr style="height: 25px;"> <td style="width: 16.74%; height: 25px; text-align: center;"></td> <td style="width: 16.66%; height: 25px; text-align: center;"></td> <td style="width: 16.58%; height: 25px; text-align: center;"></td> <td style="width: 16.66%; text-align: center;">VPAC1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.58%; text-align: center;">AEQ</td> </tr> </tbody> </table></div> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <h3><strong>CNS panel</strong></h3> <p><p>Profile your GPCR modulator against a panel of 36 CNS-focused receptors. Compounds are tested for agonist and antagonist activities in functional assays favoring the natural coupling of each receptor, increasing the chances of picking up allosteric effects.</p> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <p><div class="table-wrapper"><table style="width: 100%; border-collapse: collapse;" border="1"> <tbody> <tr> <td style="width: 16.66%; text-align: center;"><strong>Target</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Natural coupling</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Assay</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Target</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Natural coupling</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Assay</strong></td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Serotonin 5-HT<sub>1A</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;" width="44">GTP纬S</td> <td style="width: 16.66%; text-align: center;" width="132">Muscarinic M<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;" width="46">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Serotonin 5-HT<sub>2A</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Muscarinic M<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Serotonin 5-HT<sub>2Ce</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Muscarinic M<sub>3</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Adenosine A<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Muscarinic M<sub>4</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Adrenergic聽 alpha<sub>1B</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Muscarinic M<sub>5</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Adrenergic聽 alpha<sub>2A</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Nociceptin OFQ (NOP)</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Bombesin B<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Neurokinin NK<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Cannabinoid CB<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Neurokinin NK<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Cholecystokinin CCK<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;">Neuropeptide NPY<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;">Corticotropin CRF1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Neurotensin NT<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;">Corticotropin CRF2b</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Opioid OP1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Dopamine D<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>olf, </sub>G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Opioid OP2</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Dopamine D<sub>2L</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Opioid OP3</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Galanin GAL<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Orexin OX<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Histamine H<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Orexin OX<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Histamine H<sub>3</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> <td style="width: 16.66%; text-align: center;" width="132">Somatostatin sst2</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">MCH<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;">Vasopressin V<sub>1b</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">mGluR<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;">PAC1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;"></td> <td style="width: 16.66%; text-align: center;"></td> <td style="width: 16.66%; text-align: center;"></td> <td style="width: 16.66%; text-align: center;"></td> <td style="width: 16.66%; text-align: center;" width="100"></td> <td style="width: 16.66%; text-align: center;"></td> </tr> </tbody> </table></div> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <h3><strong>Metabolic panel</strong></h3> <p><p>Profile your compounds against a panel of 54聽GPCR implicated in metabolic regulation and diseases. Compounds are tested for agonist and antagonist activities in functional assays favoring the natural coupling of each receptor, increasing the chances of picking up allosteric effects.</p> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <p><div class="table-wrapper"><table style="width: 100%; border-collapse: collapse;" border="1"> <tbody> <tr> <td style="width: 16.66%; text-align: center;"><strong>Target</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Natural coupling</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Assay</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Target</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Natural coupling</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Assay</strong></td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">Serotonin 5-HT<sub>2Ce</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;" width="44">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Histamine H<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;" width="46">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">Adenosine A<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Histamine H<sub>3</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">Adenosine A<sub>2B</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">MCH1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">Adrenergic beta<sub>3</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">MC4</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">Adrenergic聽 alpha<sub>1B</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;">MC5</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">Adrenergic聽 alpha<sub>2A</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Muscarinic M<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">Angiotensin AT<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Muscarinic M<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">Bombesin BB1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Muscarinic M<sub>3</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">Bombesin BB2</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">NMUR1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">Bombesin BB3</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;">Neuropeptide NPY<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">Bradykinin B2</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Neurotensin NT1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;">Calcitonin CGRP</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Niacin receptor</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">Calcium CaS</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Nociceptin OFQ (NOP)</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">Cannabinoid CB<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> <td style="width: 16.66%; text-align: center;" width="132">Opioid OP2</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">Cannabinoid CB<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> <td style="width: 16.66%; text-align: center;" width="132">Opioid OP3</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;">Chemokine CCR2b</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> <td style="width: 16.66%; text-align: center;" width="132">Orexin OX1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;">Chemokine CCR4</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> <td style="width: 16.66%; text-align: center;" width="132">Orexin OX2</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;">Chemokine CXCR3</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> <td style="width: 16.66%; text-align: center;" width="132">Oxytocin OT1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">Cholecystokinin CCK<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Prokineticin PKR2</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">Corticotropin CRF2b</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Prostanoid EP2</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">FFA1 /GPR40</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">PTH<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">FFA2 / GPR43</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub>, G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Secretin</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">Galanin GAL2</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="132">Somatostatin sst<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">GIP</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="132">Urotensin-II</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="130">GLP-1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;">Vasopressin V<sub>1a</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;">Glucagon</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;">PAC1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;">GPR7</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> <td style="width: 16.66%; text-align: center;">VPAC2</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> </tbody> </table></div> <p> </p> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <h3><strong>Inflammation panel</strong></h3> <p><p>Profile your compounds against a panel of 56 GPCR playing a role in immune response and inflammation. Compounds are tested for agonist and antagonist activities in functional assays favoring the natural coupling of each receptor, increasing the chances of picking up allosteric effects.</p> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <p><div class="table-wrapper"><table style="width: 100%; border-collapse: collapse;" border="1"> <tbody> <tr> <td style="width: 16.66%; text-align: center;"><strong>Target</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Natural coupling</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Assay</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Target</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Natural coupling</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Assay</strong></td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Serotonin 5-HT<sub>2A</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;" width="60">AEQ</td> <td style="width: 16.66%; text-align: center;" width="211">GPR109a</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;" width="46">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Adenosine A<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;">Leukotrien BLT<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o, </sub>G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Adenosine A<sub>2A</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;">Leukotrien CysLT<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Adenosine A<sub>3</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="211">Leukotrien CysLT<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Complement C3a</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTPgS</td> <td style="width: 16.66%; text-align: center;" width="211">Muscarinic M<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTPgS</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Complement C5a</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTPgS</td> <td style="width: 16.66%; text-align: center;" width="211">Muscarinic M<sub>4</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTPgS</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Bombesin BB<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="211">Neurokinin NK<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Bombesin BB<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="211">Neuromedin U NMU-1R</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Bradykinin B<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="211">Neurotensin NTS<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;">Calcitonin CGRP</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="211">Opioid OP<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTPgS</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Cannabinoid CB<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="211">Opioid OP<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTPgS</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Chemokine CCR<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTPgS</td> <td style="width: 16.66%; text-align: center;" width="211">Opioid OP<sub>3</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTPgS</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Chemokine CCR<sub>2b</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="211">Platelet Activating Factor PAF</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Chemokine CCR<sub>3</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;">Prokineticin PKR<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Chemokine CCR<sub>4</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="211">Prostanoid DP</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Chemokine CCR<sub>5</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="211">Prostanoid EP<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Chemokine CCR<sub>6</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="211">Prostanoid EP<sub>3</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Chemokine CCR<sub>7</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="211">Prostanoid EP<sub>4</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Chemokine CCR<sub>8</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="211">Prostanoid IP<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Chemokine CCR<sub>9a</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;">Protease-activated PAR<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o, </sub>G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Chemokine CCR<sub>10</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;">Protease-activated PAR<sub>4</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o, </sub>G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;">Chemokine CXCR<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="211">Sphingosine S<sub>1</sub>P<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;">Chemokine CXCR<sub>3a</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;">Sphingosine S<sub>1</sub>P<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;">Chemokine CXCR<sub>4</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;">Sphingosine S<sub>1</sub>P<sub>4</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;">Chemokine XCR<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;">Sphingosine S<sub>1</sub>P<sub>5</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Free Fatty Acid GPR43</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o, </sub>G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;">PAC<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Histamine H<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;">VPAC<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="156">Histamine H<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;">VPAC<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> </tbody> </table></div> <p> </p> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <h3><strong>Sensory Pain panel</strong></h3> <p><p>Profile your compounds against a panel of 41 GPCR and ion channels implicated in sensory pain. Compounds are tested for agonist and antagonist activities in functional assays favoring the natural coupling of each receptor, increasing the chances of picking up allosteric effects.</p> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <p><div class="table-wrapper"><table style="width: 100%; border-collapse: collapse;" border="1"> <tbody> <tr> <td style="width: 16.66%; text-align: center;"><strong>Target</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Natural coupling</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Assay</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Target</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Natural coupling</strong></td> <td style="width: 16.66%; text-align: center;"><strong>Assay</strong></td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="161">Serotonin 5-HT<sub>1A</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;" width="44">GTP纬S</td> <td style="width: 16.66%; text-align: center;" width="161">Muscarinic M<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;" width="64">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="161">Serotonin 5-HT<sub>2Ce</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="161">Muscarinic M<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="161">Adenosine A<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="161">Muscarinic M<sub>3</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="161">Adenosine A<sub>3</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="161">Muscarinic M<sub>5</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="161">Adrenergic beta<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="161">Nociceptin OFQ (NOP)</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="161">Adrenergic聽 alpha<sub>2A</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="161">Neurokinin NK<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="161">Bradykinin B2</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="161">Neurokinin NK<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="161">Cannabinoid CB<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="161">NeuromedinNMU2</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="161">Cannabinoid CB<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="161">Neuropeptide GPR7</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="161">Chemokine CCR2b</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> <td style="width: 16.66%; text-align: center;" width="161">Neurotensin NTS1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="161">Chemokine CX3CR1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> <td style="width: 16.66%; text-align: center;" width="161">Opioid OP1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="161">Cholecystokinin CCK<sub>2</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="161">Opioid OP2</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;">Calcitonin CGRP</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="161">Opioid OP3</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;">Galanin GAL1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> <td style="width: 16.66%; text-align: center;" width="161">Orexin OX1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;">GABAB1a/B2</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="161">Parathyroid Hormone PTH1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;">Glutamate mGlu2</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="161">Platelet-Activating PAF</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>s</sub></td> <td style="width: 16.66%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="161">Histamine H<sub>1</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="161">Prokineticin PKR1</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="161">Histamine H<sub>3</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> <td style="width: 16.66%; text-align: center;" width="161">Protease Activated PAR2</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11, </sub>G<sub>i</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="161">MAS related MrgX2</td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="161">TRPA1</td> <td style="width: 16.66%; text-align: center;" width="100">Calcium channel</td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="161">5-HT3</td> <td style="width: 16.66%; text-align: center;" width="100">Calcium channel</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="161">TRPV1</td> <td style="width: 16.66%; text-align: center;" width="100">Calcium channel</td> <td style="width: 16.66%; text-align: center;">IPOne</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="161">NMDA GRIN-1</td> <td style="width: 16.66%; text-align: center;" width="100">none</td> <td style="width: 16.66%; text-align: center;">RLB</td> <td style="width: 16.66%; text-align: center;" width="161"></td> <td style="width: 16.66%; text-align: center;" width="100"></td> <td style="width: 16.66%; text-align: center;"></td> </tr> </tbody> </table></div> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <h3><strong>Safety panel</strong></h3> <p><p>Profile your compounds against a panel of 44 GPCR, ion channel, transporters and enzymes for potential safety issues.</p> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <p><strong>GPCR</strong></p> <p><div class="table-wrapper"><table style="width: 100%; border-collapse: collapse;" border="1"> <tbody> <tr style="height: 25px;"> <td style="width: 16.66%; height: 25px;"><strong>Family</strong></td> <td style="width: 16.66%; height: 25px;"><strong>Target</strong></td> <td style="width: 16.66%; height: 25px;"><strong>Readout</strong></td> <td style="width: 16.66%; height: 25px;"><strong>Family</strong></td> <td style="width: 16.66%; height: 25px;"><strong>Target</strong></td> <td style="width: 16.66%; height: 25px;"><strong>Readout</strong></td> </tr> <tr style="height: 26px;"> <td style="width: 16.66%; height: 26px;" width="111">Adenosine</td> <td style="width: 16.66%; height: 26px;" width="117">A2A</td> <td style="width: 16.66%; height: 26px;">Binding</td> <td style="width: 16.66%; height: 26px;">Histamine</td> <td style="width: 16.66%; height: 26px;" width="117">H2</td> <td style="width: 16.66%; height: 26px;">Binding</td> </tr> <tr style="height: 25px;"> <td style="width: 16.66%; height: 25px;">Adrenergic</td> <td style="width: 16.66%; height: 25px;">伪1a</td> <td style="width: 16.66%; height: 25px;">Binding</td> <td style="width: 16.66%; height: 25px;">Melatonin</td> <td style="width: 16.66%; height: 25px;">MT1</td> <td style="width: 16.66%; height: 25px;">Binding</td> </tr> <tr style="height: 26px;"> <td style="width: 16.66%; height: 26px;"></td> <td style="width: 16.66%; height: 26px;">伪2a</td> <td style="width: 16.66%; height: 26px;">Binding</td> <td style="width: 16.66%; height: 26px;"></td> <td style="width: 16.66%; height: 26px;">MT2</td> <td style="width: 16.66%; height: 26px;">Binding</td> </tr> <tr style="height: 26px;"> <td style="width: 16.66%; height: 26px;"></td> <td style="width: 16.66%; height: 26px;">尾2</td> <td style="width: 16.66%; height: 26px;">Binding</td> <td style="width: 16.66%; height: 26px;">Muscarinic</td> <td style="width: 16.66%; height: 26px;">Non selective</td> <td style="width: 16.66%; height: 26px;">Binding</td> </tr> <tr style="height: 26px;"> <td style="width: 16.66%; height: 26px;">Cannabinoid</td> <td style="width: 16.66%; height: 26px;">CB1</td> <td style="width: 16.66%; height: 26px;">Binding</td> <td style="width: 16.66%; height: 26px;">Serotonin</td> <td style="width: 16.66%; height: 26px;">5-HT1A</td> <td style="width: 16.66%; height: 26px;">Binding</td> </tr> <tr style="height: 26px;"> <td style="width: 16.66%; height: 26px;">Dopamine</td> <td style="width: 16.66%; height: 26px;">D1</td> <td style="width: 16.66%; height: 26px;">Binding</td> <td style="width: 16.66%; height: 26px;"></td> <td style="width: 16.66%; height: 26px;">5-HT1B</td> <td style="width: 16.66%; height: 26px;">Binding</td> </tr> <tr style="height: 25px;"> <td style="width: 16.66%; height: 25px;"></td> <td style="width: 16.66%; height: 25px;">D2S</td> <td style="width: 16.66%; height: 25px;">Binding</td> <td style="width: 16.66%; height: 25px;"></td> <td style="width: 16.66%; height: 25px;">5-HT2A</td> <td style="width: 16.66%; height: 25px;">Binding</td> </tr> <tr style="height: 26px;"> <td style="width: 16.66%; height: 26px;">Opioid</td> <td style="width: 16.66%; height: 26px;">蟽</td> <td style="width: 16.66%; height: 26px;">Binding</td> <td style="width: 16.66%; height: 26px;"></td> <td style="width: 16.66%; height: 26px;">5-HT2B</td> <td style="width: 16.66%; height: 26px;">Binding</td> </tr> <tr style="height: 25px;"> <td style="width: 16.66%; height: 25px;"></td> <td style="width: 16.66%; height: 25px;">未</td> <td style="width: 16.66%; height: 25px;">Binding</td> <td style="width: 16.66%; height: 25px;">Cholecystokinin</td> <td style="width: 16.66%; height: 25px;">CCK1</td> <td style="width: 16.66%; height: 25px;">Binding</td> </tr> <tr style="height: 26px;"> <td style="width: 16.66%; height: 26px;"></td> <td style="width: 16.66%; height: 26px;">魏</td> <td style="width: 16.66%; height: 26px;">Binding</td> <td style="width: 16.66%; height: 26px;">Endothelin</td> <td style="width: 16.66%; height: 26px;">ETA</td> <td style="width: 16.66%; height: 26px;">Binding</td> </tr> <tr style="height: 26px;"> <td style="width: 16.66%; height: 26px;"></td> <td style="width: 16.66%; height: 26px;">渭</td> <td style="width: 16.66%; height: 26px;">Binding</td> <td style="width: 16.66%; height: 26px;"></td> <td style="width: 16.66%; height: 26px;">ETB</td> <td style="width: 16.66%; height: 26px;">Binding</td> </tr> <tr style="height: 25px;"> <td style="width: 16.66%; height: 25px;">Histamine</td> <td style="width: 16.66%; height: 25px;">H1</td> <td style="width: 16.66%; height: 25px;">Binding</td> <td style="width: 16.66%; height: 25px;">Vasopressin</td> <td style="width: 16.66%; height: 25px;">V1a</td> <td style="width: 16.66%; height: 25px;">Binding</td> </tr> </tbody> </table></div> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <p><strong>Transporters</strong></p> <p><div class="table-wrapper"><table style="width: 100%; border-collapse: collapse;" border="1"> <tbody> <tr> <td style="width: 33.33%; text-align: left;"><strong>Family</strong></td> <td style="width: 33.33%; text-align: left;"><strong>Target</strong></td> <td style="width: 33.33%; text-align: left;"><strong>Readout</strong></td> </tr> <tr> <td style="width: 33.33%;">Amine transporter</td> <td style="width: 33.33%;">DAT</td> <td style="width: 33.33%;">Binding</td> </tr> <tr> <td style="width: 33.33%;"></td> <td style="width: 33.33%;">NET</td> <td style="width: 33.33%;">Binding</td> </tr> <tr> <td style="width: 33.33%;"></td> <td style="width: 33.33%;">SERT</td> <td style="width: 33.33%;">Binding</td> </tr> </tbody> </table></div> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <p><strong>Ion channels</strong></p> <p><div class="table-wrapper"><table style="width: 100%; border-collapse: collapse;" border="1"> <tbody> <tr> <td style="width: 33.33%;"><strong>Family</strong></td> <td style="width: 33.33%;"><strong>Target</strong></td> <td style="width: 33.33%;"><strong>Readout</strong></td> </tr> <tr> <td style="width: 33.33%;">Ca<sup>2+</sup> channel</td> <td style="width: 33.33%;">L-type, DHP site</td> <td style="width: 33.33%;">Binding</td> </tr> <tr> <td style="width: 33.33%;"></td> <td style="width: 33.33%;">L-type, Verapamil site</td> <td style="width: 33.33%;">Binding</td> </tr> <tr> <td style="width: 33.33%;">K<sup>+</sup> channel</td> <td style="width: 33.33%;">hERG</td> <td style="width: 33.33%;">Binding</td> </tr> <tr> <td style="width: 33.33%;">Serotonin</td> <td style="width: 33.33%;">5-HT<sub>3</sub></td> <td style="width: 33.33%;">Binding</td> </tr> <tr> <td style="width: 33.33%;">GABA</td> <td style="width: 33.33%;">BZD (Central)</td> <td style="width: 33.33%;">Binding</td> </tr> <tr> <td style="width: 33.33%;">NMDA</td> <td style="width: 33.33%;">GRIN1</td> <td style="width: 33.33%;">Binding</td> </tr> <tr> <td style="width: 33.33%;">Nicotinic</td> <td style="width: 33.33%;">伪4尾2</td> <td style="width: 33.33%;">Binding</td> </tr> </tbody> </table></div> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <p><strong>Enzymes</strong></p> <p><div class="table-wrapper"><table style="width: 100%; border-collapse: collapse;" border="1"> <tbody> <tr style="height: 25px;"> <td style="width: 33.33%; height: 25px;"><strong>Family</strong></td> <td style="width: 33.33%; height: 25px;"><strong>Target</strong></td> <td style="width: 33.33%; height: 25px;"><strong>Readout</strong></td> </tr> <tr style="height: 25px;"> <td style="width: 33.33%; height: 25px;">Acetylcholinesterase</td> <td style="width: 33.33%; height: 25px;">AChE</td> <td style="width: 33.33%; height: 25px;">Fluorescence</td> </tr> <tr> <td style="width: 33.33%;" width="155">Cyclooxygenase</td> <td style="width: 33.33%;" width="117">COX-2</td> <td style="width: 33.33%;" width="92">Colorimetric</td> </tr> <tr> <td style="width: 33.33%;">Monoamine Oxidase</td> <td style="width: 33.33%;">MAO-A</td> <td style="width: 33.33%;">Luminescence</td> </tr> <tr> <td style="width: 33.33%;">Phosphodiesterase</td> <td style="width: 33.33%;">PDE-3</td> <td style="width: 33.33%;">HTRF</td> </tr> <tr> <td style="width: 33.33%;">Phosphodiesterase</td> <td style="width: 33.33%;">PDE-4</td> <td style="width: 33.33%;">HTRF</td> </tr> <tr> <td style="width: 33.33%;">Cytochrome P450</td> <td style="width: 33.33%;">CYP1A2</td> <td style="width: 33.33%;">Luminescence</td> </tr> <tr> <td style="width: 33.33%;"></td> <td style="width: 33.33%;">CYP2C9</td> <td style="width: 33.33%;">Luminescence</td> </tr> <tr> <td style="width: 33.33%;"></td> <td style="width: 33.33%;">CYP2D6</td> <td style="width: 33.33%;">Luminescence</td> </tr> <tr> <td style="width: 33.33%;"></td> <td style="width: 33.33%;">CYP2E1</td> <td style="width: 33.33%;">Luminescence</td> </tr> <tr> <td style="width: 33.33%;"></td> <td style="width: 33.33%;">CYP3A4</td> <td style="width: 33.33%;">Luminescence</td> </tr> </tbody> </table></div> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <h3><strong>Orphan receptors panel</strong></h3> <p><p>Profile your compounds against a panel of聽<strong><span class="orange">76 orphan receptors</span></strong>. Receptors will be tested using the most appropriate readout when signaling has been confirmed through constitutive activity (GPR3, GPR6, GPR12, GPR21…) or the use of exogenous/surrogate ligands (GPR17, GPR52…). When no better alternative exists, receptors are tested in聽the highly sensitive聽Aequorin (calcium)聽readout with forced-coupling via a promiscuous G伪16 or a chimeric Gqi5.</p> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <p><div class="table-wrapper"><table style="width: 100%; border-collapse: collapse;" border="1"> <tbody> <tr style="height: 25px;"> <td style="width: 16.66%; height: 25px; text-align: center;"><strong>Target</strong></td> <td style="width: 16.66%; height: 25px; text-align: center;"><strong>Assay</strong></td> <td style="width: 16.66%; height: 25px; text-align: center;"><strong>Target</strong></td> <td style="width: 16.66%; height: 25px; text-align: center;"><strong>Assay</strong></td> <td style="width: 16.66%; height: 25px; text-align: center;"><strong>Target</strong></td> <td style="width: 16.66%; height: 25px; text-align: center;"><strong>Assay</strong></td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR3</td> <td style="width: 16.66%; text-align: center;" width="43">cAMP</td> <td style="width: 16.66%; text-align: center;" width="164">GPR61</td> <td style="width: 16.66%; text-align: center;" width="43">cAMP</td> <td style="width: 16.66%; text-align: center;" width="149">GPR161 (RE2)</td> <td style="width: 16.66%; text-align: center;" width="43">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR4</td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="164">GPR62</td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="149">GPR162 (A-2)</td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR6</td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="164">GPR63</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="149">GPR171 (H963)</td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR12</td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="164">GPR65</td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="149">GPR173 (SREB3)</td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR17</td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="164">GPR68 (OGR1)</td> <td style="width: 16.66%; text-align: center;">IPOne</td> <td style="width: 16.66%; text-align: center;" width="149">GPR174 (DA6)</td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR18</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="164">GPR75</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="149">GPR176 (HB954)</td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR19 (GPR-NGA)</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="164">GPR78</td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="149">GPR182 (HSGPCP)</td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR20</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="164">GPR82</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="149">GPRC5A (RAIG1)</td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR21</td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="164">GPR83 (GPR72)</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="149">GPRC5B (RAIG2)</td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR22</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="164">GPR84</td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="149">GPRC5C (RAIG3)</td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR23 (LPAR4)</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="164">GPR87 (HG03)</td> <td style="width: 16.66%; text-align: center;">IPOne</td> <td style="width: 16.66%; text-align: center;" width="149">GPRC5D (RAIG4)</td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR25</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="164">GPR88</td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;">LPA<sub>5</sub> (GPR92)</td> <td style="width: 16.66%; text-align: center;">IPOne</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR26</td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="164">GPR91</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="149">MAS</td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR27 (SREB1)</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="164">GPR99</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="149">MRG</td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR30 (GPER)</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="164">GPR101</td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="149">MRGD</td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR31</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="164">GPR139</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="149">MRGE</td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR32</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="164">GPR141</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="149">MRGF (RTA)</td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR34</td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="164">GPR142</td> <td style="width: 16.66%; text-align: center;">IPOne</td> <td style="width: 16.66%; text-align: center;" width="149">P2Y5</td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR35</td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="164">GPR146</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="149">P2Y8</td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR37</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="164">GPR148</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="149">P2Y10</td> <td style="width: 16.66%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR37L1</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="164">GPR149</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="149">TAAR2 (GPR58)</td> <td style="width: 16.66%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR39</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="164">GPR150</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="149">TAAR5 (PNR)</td> <td style="width: 16.66%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR45</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="164">GPR151</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="149">TAAR6 (TA4)</td> <td style="width: 16.66%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR50</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="164">GPR152</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="149">TAAR8 (TA5)</td> <td style="width: 16.66%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR52</td> <td style="width: 16.66%; text-align: center;">cAMP</td> <td style="width: 16.66%; text-align: center;" width="164">GPR153</td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.66%; text-align: center;" width="149">TAAR9 (TA3)</td> <td style="width: 16.66%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="169">GPR55</td> <td style="width: 16.66%; text-align: center;" width="43">AEQ</td> <td style="width: 16.66%; height: 25px; text-align: center;"></td> <td style="width: 16.66%; height: 25px; text-align: center;"></td> <td style="width: 16.66%; height: 25px; text-align: center;"></td> <td style="width: 16.66%; height: 25px; text-align: center;"></td> </tr> </tbody> </table></div> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <h3><strong>Metabotropic Glutamate receptors panel</strong></h3> <p><p>Profile your compounds against the 8 mGlu receptors, for agonist, antagonist and allosteric modulator activities.</p> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <p><div class="table-wrapper"><table style="width: 100%; border-collapse: collapse;" border="1"> <tbody> <tr style="height: 25px;"> <td style="width: 33.33%; height: 25px; text-align: center;"><strong>Target</strong></td> <td style="width: 33.33%; height: 25px; text-align: center;"><strong>Natural coupling</strong></td> <td style="width: 33.33%; height: 25px; text-align: center;"><strong>Readout</strong></td> </tr> <tr style="height: 26px;"> <td style="width: 33.33%; height: 26px; text-align: center;" width="156">mGluR1</td> <td style="width: 33.33%; height: 26px; text-align: center;" width="100">G<sub>q</sub></td> <td style="width: 33.33%; height: 26px; text-align: center;" width="60">AEQ</td> </tr> <tr style="height: 26px;"> <td style="width: 33.33%; height: 26px; text-align: center;" width="156">mGluR2</td> <td style="width: 33.33%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 33.33%; height: 26px; text-align: center;">cAMP</td> </tr> <tr style="height: 26px;"> <td style="width: 33.33%; height: 26px; text-align: center;" width="156">mGluR3</td> <td style="width: 33.33%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 33.33%; height: 26px; text-align: center;">AEQ</td> </tr> <tr style="height: 26px;"> <td style="width: 33.33%; height: 26px; text-align: center;" width="156">mGluR4</td> <td style="width: 33.33%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 33.33%; height: 26px; text-align: center;">GTP纬S</td> </tr> <tr style="height: 26px;"> <td style="width: 33.33%; height: 26px; text-align: center;" width="156">mGluR5</td> <td style="width: 33.33%; height: 26px; text-align: center;" width="100">G<sub>q</sub></td> <td style="width: 33.33%; height: 26px; text-align: center;">AEQ</td> </tr> <tr style="height: 26px;"> <td style="width: 33.33%; height: 26px; text-align: center;" width="156">mGluR6</td> <td style="width: 33.33%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 33.33%; height: 26px; text-align: center;">GTP纬S</td> </tr> <tr style="height: 26px;"> <td style="width: 33.33%; height: 26px; text-align: center;" width="156">mGluR7</td> <td style="width: 33.33%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 33.33%; height: 26px; text-align: center;">cAMP</td> </tr> <tr style="height: 26px;"> <td style="width: 33.33%; height: 26px; text-align: center;" width="156">mGluR8</td> <td style="width: 33.33%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 33.33%; height: 26px; text-align: center;">GTP纬S</td> </tr> </tbody> </table></div> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <h3><strong>Muscarinic receptors panel</strong></h3> <p><p>Profile your compounds against the 5 Muscarinic receptors, for agonist, antagonist and/or allosteric modulator activities.</p> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <p><div class="table-wrapper"><table style="width: 100%; border-collapse: collapse;" border="1"> <tbody> <tr> <td style="width: 33.33%; text-align: center;"><strong>Target</strong></td> <td style="width: 33.33%; text-align: center;"><strong>Natural coupling</strong></td> <td style="width: 33.33%; text-align: center;"><strong>Assay</strong></td> </tr> <tr> <td style="width: 33.33%; text-align: center;" width="136">M1</td> <td style="width: 33.33%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 33.33%; text-align: center;" width="44">AEQ</td> </tr> <tr> <td style="width: 33.33%; text-align: center;" width="136">M2</td> <td style="width: 33.33%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 33.33%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 33.33%; text-align: center;" width="136">M3</td> <td style="width: 33.33%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 33.33%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 33.33%; text-align: center;" width="136">M4</td> <td style="width: 33.33%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 33.33%; text-align: center;">GTP纬S</td> </tr> <tr> <td style="width: 33.33%; text-align: center;" width="136">M5</td> <td style="width: 33.33%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 33.33%; text-align: center;">AEQ</td> </tr> </tbody> </table></div> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <h3><strong>Serotonin receptors panel</strong></h3> <p><p>Profile your compounds against the聽14聽Serotonin receptor subtypes, for agonist and聽antagonist activities.</p> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <p><div class="table-wrapper"><table style="width: 100%; border-collapse: collapse;" border="1"> <tbody> <tr style="height: 25px;"> <td style="width: 16.66%; height: 25px; text-align: center;"><strong>Target</strong></td> <td style="width: 16.66%; height: 25px; text-align: center;"><strong>Natural coupling</strong></td> <td style="width: 16.66%; height: 25px; text-align: center;"><strong>Assay</strong></td> <td style="width: 16.67%; text-align: center;"><strong>Target</strong></td> <td style="width: 16.67%; text-align: center;"><strong>Natural coupling</strong></td> <td style="width: 16.67%; text-align: center;"><strong>Assay</strong></td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="136">Serotonin 5-HT<sub>1A</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;" width="44">GTP纬S</td> <td style="width: 16.67%; text-align: center;" width="132">Serotonin 5-HT<sub>2Ce</sub></td> <td style="width: 16.67%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.67%; text-align: center;" width="46">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="136">Serotonin 5-HT<sub>1B</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> <td style="width: 16.67%; text-align: center;" width="132">Serotonin 5-HT<sub>2Cne</sub></td> <td style="width: 16.67%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.67%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="136">Serotonin 5-HT<sub>1D</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> <td style="width: 16.67%; text-align: center;" width="132">Serotonin 5-HT<sub>3</sub></td> <td style="width: 16.67%; text-align: center;" width="100">Ion channel</td> <td style="width: 16.67%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="136">Serotonin 5-HT<sub>1E</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> <td style="width: 16.67%; text-align: center;" width="132">Serotonin 5-HT<sub>4e</sub></td> <td style="width: 16.67%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.67%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="136">Serotonin 5-HT<sub>1F</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; text-align: center;">GTP纬S</td> <td style="width: 16.67%; text-align: center;" width="132">Serotonin 5-HT<sub>5</sub></td> <td style="width: 16.67%; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.67%; text-align: center;">AEQ</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="136">Serotonin 5-HT<sub>2A</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.67%; text-align: center;" width="132">Serotonin 5-HT<sub>6</sub></td> <td style="width: 16.67%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.67%; text-align: center;">cAMP</td> </tr> <tr> <td style="width: 16.66%; text-align: center;" width="136">Serotonin 5-HT<sub>2B</sub></td> <td style="width: 16.66%; text-align: center;" width="100">G<sub>q/11</sub></td> <td style="width: 16.66%; text-align: center;">AEQ</td> <td style="width: 16.67%; text-align: center;" width="132">Serotonin 5-HT<sub>7</sub></td> <td style="width: 16.67%; text-align: center;" width="100">G<sub>s</sub></td> <td style="width: 16.67%; text-align: center;">cAMP</td> </tr> </tbody> </table></div> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <h3><strong>Chemokine receptors panel</strong></h3> <p><p>Profile your compounds against the 21 human chemokine receptors.</p> </p> </div> </div> </div> <div class="content content-text content-text--left"> <div class="container container--small"> <div class="content-text-wrapper typeset"> <p><div class="table-wrapper"><table style="width: 100%; border-collapse: collapse;" border="1"> <tbody> <tr style="height: 25px;"> <td style="width: 16.66%; height: 25px; text-align: center;"><strong>Target</strong></td> <td style="width: 16.66%; height: 25px; text-align: center;"><strong>Natural coupling</strong></td> <td style="width: 16.66%; height: 25px; text-align: center;"><strong>Assay</strong></td> <td style="width: 16.66%; height: 25px; text-align: center;"><strong>Target</strong></td> <td style="width: 16.66%; height: 25px; text-align: center;"><strong>Natural coupling</strong></td> <td style="width: 16.66%; height: 25px; text-align: center;"><strong>Assay</strong></td> </tr> <tr style="height: 26px;"> <td style="width: 16.66%; height: 26px; text-align: center;" width="156">CCR1</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;" width="60">GTP纬S</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="211">CXCR1</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;" width="61">AEQ</td> </tr> <tr style="height: 26px;"> <td style="width: 16.66%; height: 26px; text-align: center;" width="156">CCR2</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;">AEQ</td> <td style="width: 16.66%; height: 26px; text-align: center;">CXCR2</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;">AEQ</td> </tr> <tr style="height: 26px;"> <td style="width: 16.66%; height: 26px; text-align: center;" width="156">CCR3</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;">AEQ</td> <td style="width: 16.66%; height: 26px; text-align: center;">CXCR3a</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;">AEQ</td> </tr> <tr style="height: 26px;"> <td style="width: 16.66%; height: 26px; text-align: center;" width="156">CCR4</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;">AEQ</td> <td style="width: 16.66%; height: 26px; text-align: center;">CXCR3b</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;">AEQ</td> </tr> <tr style="height: 26px;"> <td style="width: 16.66%; height: 26px; text-align: center;" width="156">CCR5</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;">AEQ</td> <td style="width: 16.66%; height: 26px; text-align: center;">CXCR4</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;">AEQ</td> </tr> <tr style="height: 26px;"> <td style="width: 16.66%; height: 26px; text-align: center;" width="156">CCR6</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;">AEQ</td> <td style="width: 16.66%; height: 26px; text-align: center;">CXCR5</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;">AEQ</td> </tr> <tr style="height: 26px;"> <td style="width: 16.66%; height: 26px; text-align: center;" width="156">CCR7</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;">AEQ</td> <td style="width: 16.66%; height: 26px; text-align: center;">CXCR6</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;">AEQ</td> </tr> <tr style="height: 26px;"> <td style="width: 16.66%; height: 26px; text-align: center;" width="156">CCR8</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;">AEQ</td> <td style="width: 16.66%; height: 26px; text-align: center;">CXCR7</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;">RLB</td> </tr> <tr style="height: 26px;"> <td style="width: 16.66%; height: 26px; text-align: center;" width="156">CCR9a</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;">AEQ</td> <td style="width: 16.66%; height: 26px; text-align: center;">CX3CR1</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;">AEQ</td> </tr> <tr style="height: 26px;"> <td style="width: 16.66%; height: 26px; text-align: center;" width="156">CCR10</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;">AEQ</td> <td style="width: 16.66%; height: 26px; text-align: center;">XCR1</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;">AEQ</td> </tr> <tr style="height: 26px;"> <td style="width: 16.66%; height: 26px; text-align: center;" width="156">ChemR23</td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100">G<sub>i/o</sub></td> <td style="width: 16.66%; height: 26px; text-align: center;">AEQ</td> <td style="width: 16.66%; height: 26px; text-align: center;"></td> <td style="width: 16.66%; height: 26px; text-align: center;" width="100"></td> <td style="width: 16.66%; 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