Clean Cells on LinkedIn: #geneticstability #celltherapy #genetherapy #clonalselection #karyotyping…

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A great…"> <meta property="og:title" content="Clean Cells on LinkedIn: #geneticstability #celltherapy #genetherapy #clonalselection #karyotyping…"> <meta name="twitter:title" content="Clean Cells on LinkedIn: #geneticstability #celltherapy #genetherapy #clonalselection #karyotyping…"> <title>Clean Cells on LinkedIn: #geneticstability #celltherapy #genetherapy #clonalselection #karyotyping…</title> <meta property="og:video" content="https://dms.licdn.com/playlist/vid/v2/D4E05AQHPR8c-4I5oEQ/mp4-640p-30fp-crf28/mp4-640p-30fp-crf28/0/1713853302266?e=2147483647&v=beta&t=OL1e3sj2if1gF5FbVTnWAC_SQKJjQSLRilnPp9NQ-1o"> <meta name="twitter:player" content="https://www.linkedin.com/embed/feed/update/urn:li:activity:7188484283898941442?compact=true"> <meta name="twitter:card" content="player"> <meta name="twitter:player:height" content="720"> <meta name="twitter:player:width" content="720">  <meta name="robots" content="noarchive, max-image-preview:large"> <meta property="lnkd:url" content="https://www.linkedin.com/feed/update/urn:li:activity:7188484283898941442"> <meta property="og:type" content="article"> <meta property="og:url" content="https://www.linkedin.com/posts/clean-cells_geneticstability-celltherapy-genetherapy-activity-7188484283898941442-7RVq"> <meta property="og:image" content="https://media.licdn.com/dms/image/v2/D4E05AQHPR8c-4I5oEQ/videocover-high/videocover-high/0/1713853300375?e=2147483647&v=beta&t=Zd0CsCCKWG-ONWt63b9vjDve_nN8nVPhmeq9dWdLCGc"> <meta name="twitter:image" content="https://media.licdn.com/dms/image/v2/D4E05AQHPR8c-4I5oEQ/videocover-high/videocover-high/0/1713853300375?e=2147483647&v=beta&t=Zd0CsCCKWG-ONWt63b9vjDve_nN8nVPhmeq9dWdLCGc"> <meta name="twitter:site" content="@linkedin"> <meta property="twitter:url" content="https://www.linkedin.com/posts/clean-cells_geneticstability-celltherapy-genetherapy-activity-7188484283898941442-7RVq"> <meta name="clientSideIngraphs" content="1" data-gauge-metric-endpoint="/feedcontent-guest/api/ingraphs/gauge" data-counter-metric-endpoint="/feedcontent-guest/api/ingraphs/counter"> <link rel="stylesheet" href="https://static.licdn.com/aero-v1/sc/h/1hrv66730ff3p711k86f1bnlj"> <script type="application/ld+json"> {"@context":"http://schema.org","@type":"VideoObject","@id":"https://www.linkedin.com/posts/clean-cells_geneticstability-celltherapy-genetherapy-activity-7188484283898941442-7RVq","datePublished":"2024-04-23T10:30:08.834Z","comment":[],"commentCount":0,"contentUrl":"https://dms.licdn.com/playlist/vid/v2/D4E05AQHPR8c-4I5oEQ/mp4-640p-30fp-crf28/mp4-640p-30fp-crf28/0/1713853302266?e=2147483647&v=beta&t=OL1e3sj2if1gF5FbVTnWAC_SQKJjQSLRilnPp9NQ-1o","creator":{"name":"Clean Cells","image":{"url":"https://media.licdn.com/dms/image/v2/C560BAQFUQqm4gf75VQ/company-logo_100_100/company-logo_100_100/0/1630631629290/clean_cells_logo?e=2147483647&v=beta&t=ISLKYzCL_YIE5Q_2OTH-nSAxOIW4y5Zuu5JKokaEnUs","@type":"ImageObject"},"url":"https://fr.linkedin.com/company/clean-cells","@type":"Organization","interactionStatistic":{"@type":"InteractionCounter","interactionType":"http://schema.org/FollowAction","userInteractionCount":0}},"duration":"PT10S","embedUrl":"https://www.linkedin.com/embed/feed/update/urn:li:activity:7188484283898941442?compact=true","interactionStatistic":[{"@type":"InteractionCounter","interactionType":"http://schema.org/LikeAction","userInteractionCount":19},{"@type":"InteractionCounter","interactionType":"https://schema.org/CommentAction","userInteractionCount":0}],"isFamilyFriendly":true,"keywords":"geneticstability, celltherapy, genetherapy, clonalselection, karyotyping, fishanalysis, cart, carnk, lymphocytes, ipscs, cellsubstrates, gmpkaryotyping","name":"Clean Cells on LinkedIn: #geneticstability #celltherapy #genetherapy #clonalselection #karyotyping…","thumbnailUrl":"https://media.licdn.com/dms/image/v2/D4E05AQHPR8c-4I5oEQ/videocover-high/videocover-high/0/1713853300375?e=2147483647&v=beta&t=Zd0CsCCKWG-ONWt63b9vjDve_nN8nVPhmeq9dWdLCGc","uploadDate":"2024-04-23T10:30:08.834Z","description":"Don't forget that this week Andrea Pelikan and Vasileios N. Georgakakos, MSc, PhD will be at the Crispr Medicine Conference in Copenhagen. \n\nA great opportunity to discuss about your cell and gene therapy projects! \n\nOur expert in cytogenetic, Dr Vasileios N. Georgakakos, MSc, PhD will also be hosting a talk tomorrow at 3.30 pm !\n\nDuring this talk, we will share our decade of experience in evaluating the genetic stability of cell therapy products from their development and into Phase III trials and in preparation to their market authorization using our GMP-validated karyotype and FISH assays.\n\nIndeed, in the last two decades, there has been a bloom in the development of cell-based medicinal products and especially in the immunotherapy field using modified immune cells against disease. During the long development and production cycle of each novel cell therapy product, the critical question is always the same: Is it safe? \n\nLet's meet !\n\n#geneticstability #celltherapy #genetherapy #clonalselection #karyotyping \n#fishanalysis #CarT #CarNK #lymphocytes #iPSCs #cellsubstrates #GMPkaryotyping","potentialAction":{"@type":"SeekToAction","target":"https://www.linkedin.com/posts/clean-cells_geneticstability-celltherapy-genetherapy-activity-7188484283898941442-7RVq?t={seek_to_second_number}","startOffset-input":"required name=seek_to_second_number"}} </script>  </head> <body dir="ltr">  <form class="google-auth" action="https://www.linkedin.com/uas/login-submit" method="post"> <input name="loginCsrfParam" value="02bf379e-18e6-436e-8361-fe189a409645" type="hidden">  <input name="trk" value="public_post_google-one-tap-submit" type="hidden"> <code id="termsAndConditionsRendered" style="display: none"></code> <div class="google-one-tap__module hidden fixed flex flex-col 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class="core-rail mx-auto papabear:w-core-rail-width mamabear:max-w-[790px] babybear:max-w-[790px]"> <div class="details mx-details-container-padding"> <section class="mb-3"> <h1 class="section-title mb-2"> Clean Cells’ Post </h1> <article class="relative px-2 pb-0 bg-color-background-container container-lined pt-1.5 main-feed-activity-card main-feed-activity-card-with-comments" data-activity-urn="urn:li:activity:7188484283898941442" data-featured-activity-urn="urn:li:activity:7188484283898941442" data-attributed-urn="urn:li:ugcPost:7188421718670028800">   <div class="flex"> <div class="base-main-feed-card__entity-lockup"> <div class="flex items-center font-sans mb-1" data-test-id="main-feed-activity-card__entity-lockup"> <a href="https://fr.linkedin.com/company/clean-cells?trk=public_post_feed-actor-image" class="relative" data-tracking-control-name="public_post_feed-actor-image" data-tracking-will-navigate> <img class="inline-block relative w-6 h-6 " 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class="flex-none"> 7mo  </time>  </span> </div>  </div> </div> <div class="ellipsis-menu absolute right-0 top-0 main-feed-activity-card__ellipsis-menu !top-auto !relative !mr-1" data-test-id="main-feed-activity-card__ellipsis-menu"> <div class="collapsible-dropdown flex items-center relative hyphens-auto"> <button class="ellipsis-menu__trigger collapsible-dropdown__button btn-md btn-tertiary cursor-pointer !py-[6px] !px-1 flex items-center rounded-[50%] " aria-expanded="false" aria-label="Open menu" data-tracking-control-name="public_post_ellipsis-menu-trigger" tabindex="0"> <icon class="ellipsis-menu__trigger-icon m-0 p-0 centered-icon" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/671xosfpvk4c0kqtyl87hashi"></icon> </button> <ul class="collapsible-dropdown__list hidden container-raised absolute w-auto overflow-y-auto flex-col items-stretch z-1 bottom-auto top-[100%]" role="menu" tabindex="-1"> <li class="ellipsis-menu__item border-t-1 border-solid border-color-border-low-emphasis first-of-type:border-none flex"> <a href="/uas/login?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Fposts%2Fclean-cells_geneticstability-celltherapy-genetherapy-activity-7188484283898941442-7RVq&trk=public_post_ellipsis-menu-semaphore-sign-in-redirect&guestReportContentType=POST&_f=guest-reporting" data-tracking-control-name="public_post_ellipsis-menu-semaphore-sign-in-redirect" data-tracking-will-navigate data-item-type="semaphore" data-semaphore-content-type="POST" data-semaphore-content-urn="urn:li:activity:7188484283898941442" data-semaphore-tracking-prefix="public_post_ellipsis-menu-semaphore" data-is-logged-in="false" data-modal="semaphore__toggle" class="semaphore__toggle visited:text-color-text-secondary ellipsis-menu__semaphore ellipsis-menu__item-button flex items-center w-full p-1 cursor-pointer font-sans text-sm font-bold link-styled focus:link-styled link:no-underline active:bg-color-background-container-tint 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data-tracking-control-name="public_post-text" data-tracking-will-navigate>Vasileios N. Georgakakos, MSc, PhD</a> will be at the Crispr Medicine Conference in Copenhagen. A great opportunity to discuss about your cell and gene therapy projects! Our expert in cytogenetic, Dr <a class="link" href="https://fr.linkedin.com/in/vasileios-n-georgakakos-msc-phd-74b4b124?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>Vasileios N. Georgakakos, MSc, PhD</a> will also be hosting a talk tomorrow at 3.30 pm ! During this talk, we will share our decade of experience in evaluating the genetic stability of cell therapy products from their development and into Phase III trials and in preparation to their market authorization using our GMP-validated karyotype and FISH assays. Indeed, in the last two decades, there has been a bloom in the development of cell-based medicinal products and especially in the immunotherapy field using modified immune cells against disease. During the long development and production cycle of each novel cell therapy product, the critical question is always the same: Is it safe? Let's meet ! <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fgeneticstability&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#geneticstability</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fcelltherapy&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#celltherapy</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fgenetherapy&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#genetherapy</a> <a class="link" 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RNAi therapies have rapidly been advanced in clinical trials for the treatment of various human diseases, especially various human cancers, and the strategy of dula gene-targeted siRNAs is considered to be a good way to control complex disease systems. 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break-words " dir="ltr" data-test-id="main-feed-activity-card__commentary">At Capsida, we believe collaboration with the patient community, researchers and medical experts is fundamental to delivering our next generation, systemically delivered gene therapies. This month, we look forward to attending and presenting at the annual STXBP1 Summit+, hosted by the <a class="link" href="https://www.linkedin.com/company/stxbp1-foundation?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>STXBP1 Foundation</a>. At the meeting, we will highlight our work developing a first-in-class IV-administered gene therapy to treat genetic epilepsy due to STXBP1 mutations which is on track to enter the clinic in the first half of 2025. Capsida’s innovative approach has demonstrated preclinical brain-wide protein expression of STXBP1 needed to correct epileptic, cognitive and motor dysfunctions associated with STXBP1 mutations in a relevant disease model. Our program will be the first potential disease-modifying therapy for this disease that is estimated to impact 1 in 30,000 births. Click the link to learn more about the STXBP1 Foundation and Summit+ and the strides they are making to improve life for people living with genetic epilepsy due to STXBP1: <a class="link" href="https://lnkd.in/gysiX9dX?trk=public_post-text" target="_self" rel="nofollow" data-tracking-control-name="public_post-text" data-tracking-will-navigate>https://lnkd.in/gysiX9dX</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fstxbp1&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#STXBP1</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fgeneticepilepsy&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#GeneticEpilepsy</a> <a class="link" 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The following topics will be included in the course: Human Genome Organisation & Principles of Genetic Variation Principles of Gene Regulation and Epigenetics Single and multifactorial gene disorders Genetic Approaches to treating disease, including gene and cell therapy <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fcancer&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#Cancer</a> and cancer genomes <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Flifescience&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#lifescience</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fhagastaden&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#Hagastaden</a></p>  </div> <article aria-label="Reshared post" class="relative pt-1.5 px-2 pb-1 mb-1 babybear:pt-0.5 babybear:pb-0 babybear:mb-0 container-lined bg-color-background-container feed-reshare-content" data-test-id="feed-reshare-content" data-attributed-urn="urn:li:share:7239635124462469122" data-activity-urn="urn:li:activity:7241355131714191360" tabindex="0"> <div class="flex items-center font-sans" data-test-id="feed-reshare-content__entity-lockup"> <a href="https://www.linkedin.com/showcase/life-science-at-kth/?trk=public_post_reshare_feed-actor-image" target="_self" class="relative" data-tracking-control-name="public_post_reshare_feed-actor-image" data-tracking-will-navigate> <img class="inline-block relative w-6 h-6 " data-delayed-url="https://media.licdn.com/dms/image/v2/D4D0BAQEzb57JCf5LXA/company-logo_100_100/company-logo_100_100/0/1719256880419?e=2147483647&v=beta&t=zFjpYIG7fWJp2Ka89blwzYNLrduPva2_0Wl0-bhCTwg" data-ghost-classes="bg-color-entity-ghost-background" data-ghost-url="https://static.licdn.com/aero-v1/sc/h/cs8pjfgyw96g44ln9r7tct85f" alt="View organization page for Life Science at KTH, graphic">  </a> <div class="flex flex-col self-start min-w-0 ml-1 "> <div class="text-color-text "> <a class="text-sm link-styled no-underline leading-open" href="https://www.linkedin.com/showcase/life-science-at-kth/?trk=public_post_reshare_feed-actor-name" target="_self" data-tracking-control-name="public_post_reshare_feed-actor-name" aria-label="View organization page for Life Science at KTH" data-tracking-will-navigate> Life Science at KTH </a>  </div> <p class="!text-xs text-color-text-low-emphasis leading-[1.33333] m-0 truncate">  1,312 followers </p> <span class="!text-xs text-color-text-low-emphasis leading-[1.33333] flex"> <time class="flex-none"> 2mo  </time>  </span> </div>  </div> <div class="attributed-text-segment-list__container relative mt-1 mb-1.5 babybear:mt-0 babybear:mb-0.5"> <p class="attributed-text-segment-list__content text-color-text !text-sm whitespace-pre-wrap break-words " dir="ltr" data-test-id="feed-reshare-content__commentary">This online course aims to provide you with an understanding of the use of genome and epigenome information in medicine. The following topics will be included in the course: Human Genome Organisation & Principles of Genetic Variation Principles of Gene Regulation and Epigenetics Single and multifactorial gene disorders Genetic Approaches to treating disease, including gene and cell therapy Cancer and cancer genomes Apply no later than 15 October, the course starts 14 January. Read more and apply: <a class="link" href="https://lnkd.in/djEy69Nc?trk=public_post_reshare-text" target="_self" rel="nofollow" data-tracking-control-name="public_post_reshare-text" data-tracking-will-navigate>https://lnkd.in/djEy69Nc</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fgenomemedicine&trk=public_post_reshare-text" target="_self" data-tracking-control-name="public_post_reshare-text" data-tracking-will-navigate>#GenomeMedicine</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fgenomeediting&trk=public_post_reshare-text" target="_self" data-tracking-control-name="public_post_reshare-text" data-tracking-will-navigate>#GenomeEditing</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Flifescience&trk=public_post_reshare-text" 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data-delayed-url="https://media.licdn.com/dms/image/v2/D4D22AQHdIZZA_Q8bmg/feedshare-shrink_800/feedshare-shrink_800/0/1726063518924?e=2147483647&v=beta&t=GEQJWQqKoeuHtcjvs9J1caXIu5gFKnQVibVE9O4FLgs" data-ghost-url="https://static.licdn.com/aero-v1/sc/h/921ynb2z53z33mhm3061qvjag" alt="This course will give an advanced introduction to epigenetics and its role in health and disease, cancer, gene therapy and genome editing.">  </li> </ul>  </article> <code id="i18n_reaction_singular" style="display: none"></code> <code id="i18n_reactions_plural" style="display: none"></code> <div class="flex items-center font-sans text-sm babybear:text-xs main-feed-activity-card__social-actions"> <a href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Fposts%2Fstockholm-science-city_cancer-lifescience-hagastaden-activity-7243983030694895617-y-RF&trk=public_post_social-actions-reactions" target="_self" 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link">sign in</a> </p> </article> <code id="is-mobile" style="display: none"></code> </div> </li> <li class="mb-1.5"> <div class="link-overlay relative"> <a aria-label="Post by REPROCELL" class="absolute left-0 top-0 h-full w-full z-1 !border-0" data-tracking-control-name="link-overlay-public_post" href="https://www.linkedin.com/posts/reprocell_glioblastoma-is-a-devastating-disease-that-activity-7171489803757166592-J_4V" target="_self"></a> <article class="relative px-2 pb-0 bg-color-background-container container-lined pt-1.5 main-feed-activity-card related-posts__crosslink" data-activity-urn="urn:li:activity:7171489803757166592" data-featured-activity-urn="urn:li:activity:7171489803757166592" data-attributed-urn="urn:li:share:7171489801056038913">   <div class="flex"> <div class="base-main-feed-card__entity-lockup"> <div class="flex items-center font-sans mb-1" data-test-id="main-feed-activity-card__entity-lockup"> <a 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REPROCELL </a>  </div> <p class="!text-xs text-color-text-low-emphasis leading-[1.33333] m-0 truncate">  6,681 followers </p> <span class="!text-xs text-color-text-low-emphasis leading-[1.33333] flex"> <time class="flex-none"> 8mo  </time>  </span> </div>  </div> </div> <div class="ellipsis-menu absolute right-0 top-0 main-feed-activity-card__ellipsis-menu !top-auto !relative !mr-1" data-test-id="main-feed-activity-card__ellipsis-menu"> <div class="collapsible-dropdown flex items-center relative hyphens-auto"> <button class="ellipsis-menu__trigger collapsible-dropdown__button btn-md btn-tertiary cursor-pointer !py-[6px] !px-1 flex items-center rounded-[50%] " aria-expanded="false" aria-label="Open menu" data-tracking-control-name="public_post_ellipsis-menu-trigger" tabindex="0"> <icon class="ellipsis-menu__trigger-icon m-0 p-0 centered-icon" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/671xosfpvk4c0kqtyl87hashi"></icon> </button> <ul class="collapsible-dropdown__list hidden container-raised absolute w-auto overflow-y-auto flex-col items-stretch z-1 bottom-auto top-[100%]" role="menu" tabindex="-1"> <li class="ellipsis-menu__item border-t-1 border-solid border-color-border-low-emphasis first-of-type:border-none flex"> <a href="/uas/login?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Fposts%2Freprocell_glioblastoma-is-a-devastating-disease-that-activity-7171489803757166592-J_4V&trk=public_post_ellipsis-menu-semaphore-sign-in-redirect&guestReportContentType=POST&_f=guest-reporting" data-tracking-control-name="public_post_ellipsis-menu-semaphore-sign-in-redirect" data-tracking-will-navigate data-item-type="semaphore" data-semaphore-content-type="POST" data-semaphore-content-urn="urn:li:activity:7171489803757166592" data-semaphore-tracking-prefix="public_post_ellipsis-menu-semaphore" data-is-logged-in="false" data-modal="semaphore__toggle" class="semaphore__toggle visited:text-color-text-secondary ellipsis-menu__semaphore ellipsis-menu__item-button flex items-center w-full p-1 cursor-pointer font-sans text-sm font-bold link-styled focus:link-styled link:no-underline active:bg-color-background-container-tint focus:bg-color-background-container-tint hover:bg-color-background-container-tint outline-offset-[-2px]">  <icon class="ellipsis-menu__item-icon text-color-text h-[24px] w-[24px] mr-1" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/iq0x9q37wj214o129ai1yjut"> </icon> Report this post </a>  </li>  </ul>  </div> </div> </div> <div class="attributed-text-segment-list__container relative mt-1 mb-1.5 babybear:mt-0 babybear:mb-0.5"> <p class="attributed-text-segment-list__content text-color-text !text-sm whitespace-pre-wrap break-words " dir="ltr" data-test-id="main-feed-activity-card__commentary">Glioblastoma is a devastating disease that thus far has been difficult to treat with targeted therapies. A new publication from scientists in Sandro Matosevic' group at Purdue University describes research into developing a treatment for gliobastoma. They used REPROCELL's RNA Reprogramming technology to create iPSCs and differentiated those further into NK cells, both before and after gene editing. NK cells made from gene edited iPSCs showed promise in mouse models for immune regulation of glioblastoma, suggesting that iPSC-NK cell-based therapy is a promising avenue for developing therapies against this terrible disease. See the paper: <a class="link" href="https://hubs.li/Q02nv5S-0?trk=public_post-text" target="_self" rel="nofollow" data-tracking-control-name="public_post-text" data-tracking-will-navigate>https://hubs.li/Q02nv5S-0</a></p>  </div> <ul class="grid grid-cols-6 grid-rows-[60%_40%] w-main-feed-card-media feed-images-content list-none pl-0 " data-test-id="feed-images-content"> <li class="bg-color-background-container-tint text-[0px] col-span-full row-span-full " data-test-id="feed-images-content__list-item" data-position="0"> <img class="lazy-load w-full object-cover object-center h-full babybear:max-h-[400px]" data-delayed-url="https://media.licdn.com/dms/image/v2/D4E10AQHJOOfWVvzsHA/image-shrink_800/image-shrink_800/0/1709816403220?e=2147483647&v=beta&t=oI_nP_A4txwujxy1kX9hVM6HzHpPM8rts6HlE_Y8K30" data-ghost-url="https://static.licdn.com/aero-v1/sc/h/921ynb2z53z33mhm3061qvjag" alt="No alternative text description for this image">  </li> </ul>  <code id="i18n_reaction_singular" 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href="https://www.linkedin.com/posts/karenarabellaohanlon_crisprmedicinenews-crisprmedicine-crisprmed25-activity-7224715408002424834-tgGx" target="_self"></a> <article class="relative px-2 pb-0 bg-color-background-container container-lined pt-1.5 main-feed-activity-card related-posts__crosslink" data-activity-urn="urn:li:activity:7224715408002424834" data-featured-activity-urn="urn:li:activity:7224715408002424834" data-attributed-urn="urn:li:share:7224715407289397249">   <div class="flex"> <div class="base-main-feed-card__entity-lockup"> <div class="flex items-center font-sans mb-1" data-test-id="main-feed-activity-card__entity-lockup"> <a href="https://ie.linkedin.com/in/karenarabellaohanlon?trk=public_post_feed-actor-image" class="relative" data-tracking-control-name="public_post_feed-actor-image" data-tracking-will-navigate> <img class="inline-block relative rounded-[50%] w-6 h-6 bg-color-entity-ghost-background" 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At CRISPRMED25, <a class="link" href="https://www.linkedin.com/in/jimi-olaghere?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>Jimi Olaghere</a> will share his story about living with sickle cell disease, before and after treatment with the recently approved CRISPR therapy CASGEVY, which was co-developed by <a class="link" href="https://www.linkedin.com/company/vertex-pharmaceuticals?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>Vertex Pharmaceuticals</a> and <a class="link" href="https://www.linkedin.com/company/crispr-therapeutics?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>CRISPR Therapeutics</a>. <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fcrisprmedicinenews&trk=public_post-text" target="_self" 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data-tracking-control-name="public_post-text" data-tracking-will-navigate>#patientadvocate</a></p>  </div> <article aria-label="Reshared post" class="relative pt-1.5 px-2 pb-1 mb-1 babybear:pt-0.5 babybear:pb-0 babybear:mb-0 container-lined bg-color-background-container feed-reshare-content" data-test-id="feed-reshare-content" data-attributed-urn="urn:li:share:7224710049988833281" data-activity-urn="urn:li:activity:7224710050995474433" tabindex="0"> <div class="flex items-center font-sans" data-test-id="feed-reshare-content__entity-lockup"> <a href="https://dk.linkedin.com/company/crispr-medicine-news?trk=public_post_reshare_feed-actor-image" target="_self" class="relative" data-tracking-control-name="public_post_reshare_feed-actor-image" data-tracking-will-navigate> <img class="inline-block relative w-6 h-6 " data-delayed-url="https://media.licdn.com/dms/image/v2/C4E0BAQHWF1zez9QHJA/company-logo_100_100/company-logo_100_100/0/1630605951005/crispr_medicine_blog_logo?e=2147483647&v=beta&t=FHNg9QBoQiMyPFGW_Ch9qzrV7ro7e5puhFpxHQcYdWY" data-ghost-classes="bg-color-entity-ghost-background" data-ghost-url="https://static.licdn.com/aero-v1/sc/h/cs8pjfgyw96g44ln9r7tct85f" alt="View organization page for CRISPR Medicine News, graphic">  </a> <div class="flex flex-col self-start min-w-0 ml-1 "> <div class="text-color-text "> <a class="text-sm link-styled no-underline leading-open" href="https://dk.linkedin.com/company/crispr-medicine-news?trk=public_post_reshare_feed-actor-name" target="_self" data-tracking-control-name="public_post_reshare_feed-actor-name" aria-label="View organization page for CRISPR Medicine News" data-tracking-will-navigate> CRISPR Medicine News </a>  </div> <p class="!text-xs text-color-text-low-emphasis leading-[1.33333] m-0 truncate">  26,357 followers </p> <span class="!text-xs text-color-text-low-emphasis leading-[1.33333] flex"> <time class="flex-none"> 3mo <span aria-hidden="true" class="text-color-text-low-emphasis before:middot"></span> <span> Edited </span> </time>  </span> </div>  </div> <div class="attributed-text-segment-list__container relative mt-1 mb-1.5 babybear:mt-0 babybear:mb-0.5"> <p class="attributed-text-segment-list__content text-color-text !text-sm whitespace-pre-wrap break-words " dir="ltr" data-test-id="feed-reshare-content__commentary">𝐖𝐡𝐚𝐭 𝐝𝐨𝐞𝐬 𝐂𝐑𝐈𝐒𝐏𝐑 𝐭𝐡𝐞𝐫𝐚𝐩𝐲 𝐦𝐞𝐚𝐧 𝐭𝐨 𝐚 𝐩𝐚𝐭𝐢𝐞𝐧𝐭? 𝐇𝐞𝐚𝐫 𝐉𝐢𝐦𝐢 𝐎𝐥𝐚𝐠𝐡𝐞𝐫𝐞'𝐬 𝐬𝐭𝐨𝐫𝐲 𝐚𝐭 𝐂𝐑𝐈𝐒𝐏𝐑𝐌𝐄𝐃25 <a class="link" href="https://www.linkedin.com/in/jimi-olaghere?trk=public_post_reshare-text" target="_self" data-tracking-control-name="public_post_reshare-text" data-tracking-will-navigate>Jimi Olaghere</a> is a CASGEVY recipient who has developed a keen interest in the advancements of cell and gene therapies, since his transformative participation in the groundbreaking clinical trial. Jimi is passionate about the positive impact that these therapies can have on patients in need and has become a staunch advocate for increased accessibility of gene therapies for sickle cell disease patients worldwide. At CRISPRMED25, Jimi will share his story about living with sickle cell disease, before and after treatment with the recently approved CRISPR therapy CASGEVY, which was co-developed by <a class="link" href="https://www.linkedin.com/company/vertex-pharmaceuticals?trk=public_post_reshare-text" target="_self" data-tracking-control-name="public_post_reshare-text" data-tracking-will-navigate>Vertex Pharmaceuticals</a> and <a class="link" href="https://www.linkedin.com/company/crispr-therapeutics?trk=public_post_reshare-text" target="_self" data-tracking-control-name="public_post_reshare-text" data-tracking-will-navigate>CRISPR Therapeutics</a>. Learn more about CRISPRMED25 and sign up to attend at the link below: <a class="link" href="https://lnkd.in/eZxqTfcS?trk=public_post_reshare-text" target="_self" rel="nofollow" data-tracking-control-name="public_post_reshare-text" data-tracking-will-navigate>https://lnkd.in/eZxqTfcS</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fcrisprmedicinenews&trk=public_post_reshare-text" target="_self" data-tracking-control-name="public_post_reshare-text" data-tracking-will-navigate>#crisprmedicinenews</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fcrisprmedicine&trk=public_post_reshare-text" target="_self" data-tracking-control-name="public_post_reshare-text" data-tracking-will-navigate>#crisprmedicine</a> <a class="link" 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<article class="relative px-2 pb-0 bg-color-background-container container-lined pt-1.5 main-feed-activity-card related-posts__crosslink" data-activity-urn="urn:li:activity:7250935868100620288" data-featured-activity-urn="urn:li:activity:7250935868100620288" data-attributed-urn="urn:li:share:7250935867500830720">   <div class="flex"> <div class="base-main-feed-card__entity-lockup"> <div class="flex items-center font-sans mb-1" data-test-id="main-feed-activity-card__entity-lockup"> <a href="https://ca.linkedin.com/in/aneal-khan-75127145?trk=public_post_feed-actor-image" class="relative" data-tracking-control-name="public_post_feed-actor-image" data-tracking-will-navigate> <img class="inline-block relative rounded-[50%] w-6 h-6 " data-delayed-url="https://media.licdn.com/dms/image/v2/C5603AQG8KqSKJbDwVA/profile-displayphoto-shrink_200_200/profile-displayphoto-shrink_200_200/0/1569986588801?e=2147483647&v=beta&t=h4__8qFJpjf3OV_2x2xVsbRPriEvIO3tMhQOBEKgXgM" 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href="/uas/login?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Fposts%2Faneal-khan-75127145_immunology-mastcell-activity-7250935868100620288-HlXz&trk=public_post_ellipsis-menu-semaphore-sign-in-redirect&guestReportContentType=POST&_f=guest-reporting" data-tracking-control-name="public_post_ellipsis-menu-semaphore-sign-in-redirect" data-tracking-will-navigate data-item-type="semaphore" data-semaphore-content-type="POST" data-semaphore-content-urn="urn:li:activity:7250935868100620288" data-semaphore-tracking-prefix="public_post_ellipsis-menu-semaphore" data-is-logged-in="false" data-modal="semaphore__toggle" class="semaphore__toggle visited:text-color-text-secondary ellipsis-menu__semaphore ellipsis-menu__item-button flex items-center w-full p-1 cursor-pointer font-sans text-sm font-bold link-styled focus:link-styled link:no-underline active:bg-color-background-container-tint focus:bg-color-background-container-tint hover:bg-color-background-container-tint outline-offset-[-2px]">  <icon class="ellipsis-menu__item-icon text-color-text h-[24px] w-[24px] mr-1" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/iq0x9q37wj214o129ai1yjut"> </icon> Report this post </a>  </li>  </ul>  </div> </div> </div> <div class="attributed-text-segment-list__container relative mt-1 mb-1.5 babybear:mt-0 babybear:mb-0.5"> <p class="attributed-text-segment-list__content text-color-text !text-sm whitespace-pre-wrap break-words " dir="ltr" data-test-id="main-feed-activity-card__commentary">Case Vignette: Mast Cell vs Autoimmune Patients was assessed some years ago by a Harvard immunologist to have mast cell activation syndrome. I think the doc was on the right track. Move to 2024 now in our catchment area and the new lowly MAGIC Clinic pediatrician/geneticist and our new mast cell protocol using a cytokine panel, histamine metabolites and gene sequencing shows: > 10 x elevation in IL-23, eotaxin-3, 3x elevation in IL-1, increased GM-CSF and increased PGD2. Normal TNFs. KITD816V negative. Does it look like autoimmune with some mast cell activation or primary mast cell activation ? Exome is pending. I don’t have a final answer but interested in your thoughts. <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fimmunology&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#immunology</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fmastcell&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#mastcell</a></p>  </div>  <code id="i18n_reaction_singular" style="display: none"></code> <code id="i18n_reactions_plural" style="display: none"></code> <div class="flex items-center font-sans text-sm babybear:text-xs main-feed-activity-card__social-actions"> <a 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Don't miss these must-adds for your Fall reading list. Minimal information for studies of extracellular vesicles 2023: relevance to cell and gene therapies <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Feditorial&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#Editorial</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fextracellularvesicles&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#ExtracellularVesicles</a> (<a class="link" href="https://lnkd.in/gs_uKm86?trk=public_post-text" target="_self" rel="nofollow" data-tracking-control-name="public_post-text" data-tracking-will-navigate>https://lnkd.in/gs_uKm86</a>) State of the art and perspectives of chimeric antigen receptor T cells cell therapy for neuroblastoma <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fcart&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#CART</a> (<a class="link" href="https://lnkd.in/gtxNJBxq?trk=public_post-text" target="_self" rel="nofollow" data-tracking-control-name="public_post-text" data-tracking-will-navigate>https://lnkd.in/gtxNJBxq</a>) International Society for Cell and Gene Therapy Clinical Translation Committee recommendations on mesenchymal stromal cells in graft-versus-host disease: easy manufacturing is faced with standardizing and commercialization challenges <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fopenaccess&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#OpenAccess</a> <a class="link" 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mesenchymal stem cell-derived small extracellular vesicles stained with CD63 (red) and Hoechst (cell nuclei, blue) <a class="link" href="https://au.linkedin.com/in/shanti-gurung-3b3b3017?trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>Shanti Gurung</a></p>  </div> <ul class="grid grid-cols-6 grid-rows-[60%_40%] w-main-feed-card-media feed-images-content list-none pl-0 " data-test-id="feed-images-content"> <li class="bg-color-background-container-tint text-[0px] col-span-full row-span-full " data-test-id="feed-images-content__list-item" data-position="0"> <img class="lazy-load w-full object-cover object-center h-full babybear:max-h-[400px]" data-delayed-url="https://media.licdn.com/dms/image/v2/D5622AQFbgE7QPIE9LQ/feedshare-shrink_2048_1536/feedshare-shrink_2048_1536/0/1727280455546?e=2147483647&v=beta&t=5jAlb-S_SLyykHq8Lj6Yi2cK5t35XfIBhCM2JMEKEic" 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border-t-1 border-color-surface-border border-solid p-3 text-center text-md text-color-text-low-emphasis"> To view or add a comment, <a href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Fposts%2Fcytotherapy_editorial-extracellularvesicles-cart-activity-7244739328596197376-cXwo&trk=public_post_feed-cta-banner-cta" target="" aria-label="To view or add a comment, sign in" data-tracking-control-name="public_post_feed-cta-banner-cta" data-tracking-will-navigate="true" class="feed-cta-banner__link link">sign in</a> </p> </article> <code id="is-mobile" style="display: none"></code> </div> </li> <li class="mb-1.5"> <div class="link-overlay relative"> <a aria-label="Post by SparingVision" class="absolute left-0 top-0 h-full w-full z-1 !border-0" data-tracking-control-name="link-overlay-public_post" href="https://www.linkedin.com/posts/sparingvision_genomicmedicines-ophthalmology-genetherapy-activity-7161333124256169984-Uee_" target="_self"></a> <article class="relative px-2 pb-0 bg-color-background-container container-lined pt-1.5 main-feed-activity-card related-posts__crosslink" data-activity-urn="urn:li:activity:7161333124256169984" data-featured-activity-urn="urn:li:activity:7161333124256169984" data-attributed-urn="urn:li:ugcPost:7161333080685727745">   <div class="flex"> <div class="base-main-feed-card__entity-lockup"> <div class="flex items-center font-sans mb-1" data-test-id="main-feed-activity-card__entity-lockup"> <a href="https://fr.linkedin.com/company/sparingvision?trk=public_post_feed-actor-image" class="relative" data-tracking-control-name="public_post_feed-actor-image" data-tracking-will-navigate> <img class="inline-block relative w-6 h-6 " data-delayed-url="https://media.licdn.com/dms/image/v2/C4D0BAQF3nfkLzJftPA/company-logo_100_100/company-logo_100_100/0/1634119264625/sparingvision_logo?e=2147483647&v=beta&t=7Qc8Pi1POvu2qohYxju0-llhA_0W_20VzjrNdevhxBY" data-ghost-classes="bg-color-entity-ghost-background" 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href="/uas/login?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Fposts%2Fsparingvision_genomicmedicines-ophthalmology-genetherapy-activity-7161333124256169984-Uee_&trk=public_post_ellipsis-menu-semaphore-sign-in-redirect&guestReportContentType=POST&_f=guest-reporting" data-tracking-control-name="public_post_ellipsis-menu-semaphore-sign-in-redirect" data-tracking-will-navigate data-item-type="semaphore" data-semaphore-content-type="POST" data-semaphore-content-urn="urn:li:activity:7161333124256169984" data-semaphore-tracking-prefix="public_post_ellipsis-menu-semaphore" data-is-logged-in="false" data-modal="semaphore__toggle" class="semaphore__toggle visited:text-color-text-secondary ellipsis-menu__semaphore ellipsis-menu__item-button flex items-center w-full p-1 cursor-pointer font-sans text-sm font-bold link-styled focus:link-styled link:no-underline active:bg-color-background-container-tint focus:bg-color-background-container-tint hover:bg-color-background-container-tint outline-offset-[-2px]">  <icon class="ellipsis-menu__item-icon text-color-text h-[24px] w-[24px] mr-1" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/iq0x9q37wj214o129ai1yjut"> </icon> Report this post </a>  </li>  </ul>  </div> </div> </div> <div class="attributed-text-segment-list__container relative mt-1 mb-1.5 babybear:mt-0 babybear:mb-0.5"> <p class="attributed-text-segment-list__content text-color-text !text-sm whitespace-pre-wrap break-words attributed-text-segment-list__content-truncated" dir="ltr" data-test-id="main-feed-activity-card__commentary">💡 Exciting News from SparingVision at the Macula Society 47th Annual Meeting! We are proud to announce that we have presented clinical data for our pioneering gene therapy, SPVN06, for the first time. This represents a significant milestone in our journey towards transforming the treatment of retinal disease. Our abstract provides information on the preliminary safety data of SPVN06, our gene-agnostic investigational gene therapy, which shows that no severe adverse events were reported in the initial groups of patients who received treatment. Most adverse events were procedural, transient, and quickly resolved. This achievement demonstrates our commitment to advancing genomic medicines and represents a step forward in our mission to lead the way in bringing new hope to millions affected by retinal diseases, for which there are currently no viable treatments. 👁️ To learn more about our findings and the impact of our research, please read the full press release here: <a class="link" href="https://lnkd.in/dN4ZTSMY?trk=public_post-text" target="_self" rel="nofollow" data-tracking-control-name="public_post-text" data-tracking-will-navigate>https://lnkd.in/dN4ZTSMY</a> <a class="link" href="https://www.linkedin.com/signup/cold-join?session_redirect=https%3A%2F%2Fwww.linkedin.com%2Ffeed%2Fhashtag%2Fgenomicmedicines&trk=public_post-text" target="_self" data-tracking-control-name="public_post-text" data-tracking-will-navigate>#GenomicMedicines</a> <a class="link" 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have demonstrated the efficacy of a compact, specific and AAV-compatible CRISPR-Cas13 variant, Cas13bt3, for RNA-targeted gene therapy against VEGFA in retinal cells. This study used Cas13bt3 paired with a single guide RNA (sgRNA) targeting exon 4 in the VEGFA gene to selectively silence VEGFA in retinal cells, suggesting a new gene therapy approach for retinal neovascular diseases. 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class="language-selector__item" role="presentation">  <button aria-label="ਪੰਜਾਬੀ (Punjabi)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-pa_IN" data-locale="pa_IN" role="menuitem" lang="pa_IN"> ਪੰਜਾਬੀ (Punjabi) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Polski (Polish)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-pl_PL" data-locale="pl_PL" role="menuitem" lang="pl_PL"> Polski (Polish) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Português (Portuguese)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-pt_BR" data-locale="pt_BR" role="menuitem" lang="pt_BR"> Português (Portuguese) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Română (Romanian)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-ro_RO" data-locale="ro_RO" role="menuitem" lang="ro_RO"> Română (Romanian) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Русский (Russian)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-ru_RU" data-locale="ru_RU" role="menuitem" lang="ru_RU"> Русский (Russian) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Svenska (Swedish)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-sv_SE" data-locale="sv_SE" role="menuitem" lang="sv_SE"> Svenska (Swedish) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="తెలుగు (Telugu)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-te_IN" data-locale="te_IN" role="menuitem" lang="te_IN"> తెలుగు (Telugu) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="ภาษาไทย (Thai)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-th_TH" data-locale="th_TH" role="menuitem" lang="th_TH"> ภาษาไทย (Thai) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Tagalog (Tagalog)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-tl_PH" data-locale="tl_PH" role="menuitem" lang="tl_PH"> Tagalog (Tagalog) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Türkçe (Turkish)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-tr_TR" data-locale="tr_TR" role="menuitem" lang="tr_TR"> Türkçe (Turkish) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Українська (Ukrainian)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-uk_UA" data-locale="uk_UA" role="menuitem" lang="uk_UA"> Українська (Ukrainian) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="Tiếng Việt (Vietnamese)" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-vi_VN" data-locale="vi_VN" role="menuitem" lang="vi_VN"> Tiếng Việt (Vietnamese) </button> </li> <li class="language-selector__item" role="presentation">  <button aria-label="简体中文 (Chinese (Simplified))" class="font-sans text-xs link block py-[5px] px-2 w-full hover:cursor-pointer hover:bg-color-action hover:text-color-text-on-dark focus:bg-color-action focus:text-color-text-on-dark language-selector__link !font-regular" data-tracking-control-name="language-selector-zh_CN" data-locale="zh_CN" role="menuitem" lang="zh_CN"> 简体中文 (Chinese (Simplified)) 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data-delayed-url="https://static.licdn.com/aero-v1/sc/h/cyolgscd0imw2ldqppkrb84vo"></icon> </button> </div> </li> </ul>  </footer>  <div class="cta-modal overflow-hidden container-raised z-10 fixed bottom-3 right-3 min-h-[56px] p-2 babybear:hidden windows-app-upsell windows-app-upsell--msft flex flex-col p-2 w-[359px] !bg-[#F1F8FA] opacity-90 backdrop-blur-[2px] z-1" data-impression-id="public_post_windows-app-upsell_cta-modal" role="dialog" aria-labelledby="cta-modal-header" aria-describedby="cta-modal-subheader"> <div class="windows-app-upsell__linkedin-title-container pt-[6px] mb-1.5 flex align-center"> <icon class="windows-app-upsell__linkedin-bug-icon block w-[21px] h-[21px]" data-svg-class-name="windows-app-upsell__linkedin-bug-icon-svg w-[21px] h-[21px]" data-delayed-url="https://static.licdn.com/aero-v1/sc/h/euqjj7tf5wvr33frd3x1jj9s"></icon> <p class="windows-app-upsell__linkedin-title uppercase text-xs text-color-text-secondary leading-[21px] ml-1"> LinkedIn </p> </div> <p 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