Search results for: V. Capra

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Capra</title> <meta name="description" content="Search results for: V. Capra"> <meta name="keywords" content="V. Capra"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="V. 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Capra"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 2</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: V. Capra</h1> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> A New Gateway for Rheumatoid Arthritis: COXIBs with an Improved Cardiovascular Profile</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=M.%20Hoxha">M. Hoxha</a>, <a href="https://publications.waset.org/search?q=V.%20Capra"> V. Capra</a>, <a href="https://publications.waset.org/search?q=C.%20Buccellati"> C. Buccellati</a>, <a href="https://publications.waset.org/search?q=A.%20Sala"> A. Sala</a>, <a href="https://publications.waset.org/search?q=C.%20Cena"> C. Cena</a>, <a href="https://publications.waset.org/search?q=R.%20Fruttero"> R. Fruttero</a>, <a href="https://publications.waset.org/search?q=M.%20Bertinaria"> M. Bertinaria</a>, <a href="https://publications.waset.org/search?q=G.%20E.%20Rovati"> G. E. Rovati</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Today COXIBs are used in the treatment of arthritis and many other painful conditions in selected patients with high gastrointestinal risk and low cardiovascular (CV) risk. Previously, we have identified an unexpected mechanism of action of a traditional non-steroidal anti-inflammatory drug (NSAID) (diclofenac) and a specific inhibitor of cyclooxygenase-2 (COXIB) (lumiracoxib) demonstrating that they possess weak competitive antagonism at the thromboxane receptor (TP). We hypothesize that modifying the structure of a known COXIB so that it becomes also a more potent TP antagonist will preserve the anti-inflammatory and gastrointestinal safety typical of COXIBs and prevent the CV risk associated with long term therapy.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Cyclooxygenase" title="Cyclooxygenase">Cyclooxygenase</a>, <a href="https://publications.waset.org/search?q=inflammation" title=" inflammation"> inflammation</a>, <a href="https://publications.waset.org/search?q=lumiracoxib" title=" lumiracoxib"> lumiracoxib</a>, <a href="https://publications.waset.org/search?q=thromboxane%20A2." title=" thromboxane A2. "> thromboxane A2. </a> </p> <a href="https://publications.waset.org/9998299/a-new-gateway-for-rheumatoid-arthritis-coxibs-with-an-improved-cardiovascular-profile" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/9998299/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/9998299/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/9998299/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/9998299/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/9998299/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/9998299/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/9998299/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/9998299/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/9998299/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/9998299/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/9998299.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2043</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> DNA Polymorphism Studies of 尾-Lactoglobulin Gene in Saudi Goats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Amr%20A.%20El%20Hanafy">Amr A. El Hanafy</a>, <a href="https://publications.waset.org/search?q=Muhammad%20Qureshi"> Muhammad Qureshi</a>, <a href="https://publications.waset.org/search?q=Jamal%20Sabir"> Jamal Sabir</a>, <a href="https://publications.waset.org/search?q=Mohamed%20Mutawakil"> Mohamed Mutawakil</a>, <a href="https://publications.waset.org/search?q=Mohamed%20M.%20Ahmed"> Mohamed M. Ahmed</a>, <a href="https://publications.waset.org/search?q=Hassan%20El%20Ashmaoui"> Hassan El Ashmaoui</a>, <a href="https://publications.waset.org/search?q=Hassan%20Ramadan"> Hassan Ramadan</a>, <a href="https://publications.waset.org/search?q=Mohamed%20Abou-Alsoud"> Mohamed Abou-Alsoud</a>, <a href="https://publications.waset.org/search?q=Mahmoud%20Abdel%20Sadek"> Mahmoud Abdel Sadek</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Domestic goats (Capra hircus) are extremely diverse species and principal animal genetic resource of the developing world. These facilitate a persistent supply of meat, milk, fibre, and skin and are considered as important revenue generators in small pastoral environments. This study aimed to fingerprint β-LG gene at PCR-RFLP level in native Saudi goat breeds (Ardi, Habsi and Harri) in an attempt to have a preliminary image of β-LG genotypic patterns in Saudi breeds as compared to other foreign breeds such as Indian and Egyptian. Also, the Phylogenetic analysis was done to investigate evolutionary trends and similarities among the caprine β-LG gene with that of the other domestic specie, viz. cow, buffalo and sheep. Blood samples were collected from 300 animals (100 for each breed) and genomic DNA was extracted. A fragment of the β-LG gene (427bp) was amplified using specific primers. Subsequent digestion with Sac II restriction endonuclease revealed two alleles (A and B) and three different banding patterns or genotypes i.e. AA, AB and BB. The statistical analysis showed a general trend that β-LG AA genotype had higher milk yield than β-LG AB and β-LG BB genotypes. Nucleotide sequencing of the selected β-LG fragments was done and submitted to GenBank NCBI (Accession No. KJ544248, KJ588275, KJ588276, KJ783455, KJ783456 and KJ874959). Phylogenetic analysis on the basis of nucleotide sequences of native Saudi goats indicated evolutional similarity with the GenBank reference sequences of goat, Bubalus bubalis and Bos taurus. However, the origin of sheep which is the most closely related from the evolutionary point of view, was located some distance away.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=%CE%B2-Lactoglobulin" title="尾-Lactoglobulin">尾-Lactoglobulin</a>, <a href="https://publications.waset.org/search?q=Saudi%20goats" title=" Saudi goats"> Saudi goats</a>, <a href="https://publications.waset.org/search?q=PCR-RFLP" title=" PCR-RFLP"> PCR-RFLP</a>, <a href="https://publications.waset.org/search?q=Phylogenetic%20analysis." title=" Phylogenetic analysis."> Phylogenetic analysis.</a> </p> <a href="https://publications.waset.org/10000025/dna-polymorphism-studies-of-v-lactoglobulin-gene-in-saudi-goats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10000025/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10000025/bibtex" target="_blank" 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Search results for: V. Capra