CINXE.COM

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</div> </div> <div class="pw_right col-xs-12 col-sm-8 col-md-9"> <div class="search_mobile_buttons"> <div class="pw_menu_toggle btn btn-tertiary">Show Categories</div> </div> <div class="pw_header"> <h1>MDSC-Mediated Mechanisms of Immunosuppression</h1> <p id="pw-intro-txt">Click on the mechanisms of MDSC-mediated immunosuppression listed on the left below under Explore Pathways to see the specific MDSC-associated molecules that are involved in each mechanism and an explanation of how they negatively regulate the immune response. <br></p> <div id="pw-con" data-mapname="" data-primary_segment="mdscmechanisms_all"> <div id="pw-main-nav-wrapper"> <div class="row"> <div id="pw-button-nav-top" class="col-xs-12 col-sm-12"> <div class="row"> <div id="pw-button-nav"> <div class="dropdown col-xs-12 col-sm-6 col-md-4"> <button class="btn-pw" type="button" data-toggle="dropup">Explore Pathways<span class="caret"></span></button> <ul id="pathwaynav" class="dropdown-content"> <li data-segment="MDSC_PGE2" data-background_image="production-of-pge2_static_v2.png" data-pathway_segment="MDSC_PGE2" class="pw_rdblue_sm pw_sm_btn"><span>Production of PGE<sub>2</sub></span></li> <li data-segment="MDSC_AminoAcidDepletion" data-background_image="amino-acid-depletion_static_v2.png" data-pathway_segment="MDSC_AminoAcidDepletion" class="pw_rdblue_sm pw_sm_btn"><span>Amino Acid Depletion and Production of Immunosuppressive Metabolites</span></li> <li data-segment="MDSC_ROSandRNS" data-background_image="gen-ros-rns_static_v2.png" data-pathway_segment="MDSC_ROSandRNS" class="pw_rdblue_sm pw_sm_btn"><span>Generation of Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS)</span></li> <li data-segment="MDSC_TCellInhibitoryApoptoticReceptors" data-background_image="direct-engagement-of-t-cell_static_v2.png" data-pathway_segment="MDSC_TCellInhibitoryApoptoticReceptors" class="pw_rdblue_sm pw_sm_btn"><span>Direct Engagement of T Cell Inhibitory and Apoptotic Receptors</span></li> <li data-segment="MDSC_ProdInhibitoryCytokines" data-background_image="production-of-inhibitory_static_v2.png" data-pathway_segment="MDSC_ProdInhibitoryCytokines" class="pw_rdblue_sm pw_sm_btn"><span>Production of Inhibitory Cytokines</span></li> <li data-segment="MDSC_InhibitionTCellHoming" data-background_image="inhibition-of-t-cell-homing_static_v2.png" data-pathway_segment="MDSC_InhibitionTCellHoming" class="pw_rdblue_sm pw_sm_btn"><span>Inhibition of T Cell Homing to the Lymph Nodes</span></li> <li data-segment="MDSC_ProdAdenosine" data-background_image="production-of-extracellular_static_v2.png" data-pathway_segment="MDSC_ProdAdenosine" class="pw_rdblue_sm pw_sm_btn"><span>Production of Extracellular Adenosine</span></li> <li data-segment="MDSC_S100A8/S100A9-MediatedAccumulation" data-background_image="s100_static_v2.png" data-pathway_segment="MDSC_S100A8/S100A9-MediatedAccumulation" class="pw_rdblue_sm pw_sm_btn"><span>S100A8/A9-Mediated Accumulation of MDSCs</span></li> <li data-segment="MDSCMechanisms_All" data-background_image="mdsc-bg_all_static_v2.png" data-pathway_segment="MDSCMechanisms_All" class="pw_sm_btn-active"><span>View Full Pathway</span></li> </ul> </div> </div> <div class="col-xs-12 col-sm-6 col-md-5" > <div id="pw-nav-subtitle"> MDSC-Mediated Mechanisms of Immunosuppression </div> </div> <div id="pw-print-button-col" class="col-xs-12 col-sm-6 col-md-3" > <a href="#print-copy-form" id="btn-get-print-copy" class="btn btn-primary"><img class="btn-icon" src="https://resources.rndsystems.com/images/Pathways/icons/icon-image.svg"/> Get Print Copy</a> </div> </div> </div> </div> </div> <div id="pw-map"> <div id="pw-maps"> <div id="el1_gry" class="mdscmechanisms_all mdsc_pge2 pw-sprite el-gray1 pw-gray" style="top:217.6000213623047px;left:311.99993896484375px;"> </div> <div id="el1_off" data-id="1" data-set="COX21" data-type="" class="mdscmechanisms_all mdsc_pge2 pw-sprite el-off1" style="top:217.6000213623047px;left:311.99993896484375px;"> </div> <div id="el1_ct" class="pw-tooltip" data-id="1"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/cox-2">COX-2</a><br> </div> </div> <div id="el2_gry" class="mdscmechanisms_all mdsc_pge2 pw-label el-gray2 pw-gray" style="top:230px;left:327px;"> COX2 </div> <div id="el2_off" data-id="2" data-set="COX21" data-type="No Products Click" class="mdscmechanisms_all mdsc_pge2 pw-label el-off2" style="top:230px;left:327px;"> COX2</div> <div id="el2_ct" class="pw-tooltip" data-id="2"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/cox-2">COX-2</a><br> </div> </div> <div id="el3_gry" class="mdscmechanisms_all mdsc_pge2 pw-sprite el-gray3 pw-gray" style="top:215.00001525878906px;left:366.99993896484375px;"> </div> <div id="el3_off" data-id="3" data-set="PGES12" data-type="No Products Click" class="mdscmechanisms_all mdsc_pge2 pw-sprite el-off3" style="top:215.00001525878906px;left:366.99993896484375px;"> </div> <div id="el3_ct" class="pw-tooltip" data-id="3"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=PGES1">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el4_gry" class="mdscmechanisms_all mdsc_pge2 pw-label el-gray4 pw-gray" style="top:227px;left:379px;"> PGES1 </div> <div id="el4_off" data-id="4" data-set="PGES12" data-type="No Products Click" class="mdscmechanisms_all mdsc_pge2 pw-label el-off4" style="top:227px;left:379px;"> PGES1</div> <div id="el4_ct" class="pw-tooltip" data-id="4"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=PGES1">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el5_gry" class="mdscmechanisms_all mdsc_pge2 pw-sprite el-gray5 pw-gray" style="top:255.40000915527344px;left:344.00006103515625px;"> </div> <div id="el5_off" data-id="5" data-set="PGE23" data-type="No Products Click" class="mdscmechanisms_all mdsc_pge2 pw-sprite el-off5" style="top:255.40000915527344px;left:344.00006103515625px;"> </div> <div id="el5_ct" class="pw-tooltip" data-id="5"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/prostaglandin-e2-pge2">PGE2</a><br> </div> </div> <div id="el6_gry" class="mdscmechanisms_all mdsc_pge2 pw-label el-gray6 pw-gray" style="top:266px;left:361px;"> PGE2 </div> <div id="el6_off" data-id="6" data-set="PGE23" data-type="No Products Click" class="mdscmechanisms_all mdsc_pge2 pw-label el-off6" style="top:266px;left:361px;"> PGE2</div> <div id="el6_ct" class="pw-tooltip" data-id="6"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/prostaglandin-e2-pge2">PGE2</a><br> </div> </div> <div id="el7_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label2 pw-left el-gray7 pw-gray" style="top:65px;left:609px;"> <h2 class="pw_txtBox">Amino Acid Depletion<br>and Production of<br>Immunosuppressive<br>Metabolites</h2> </div> <div id="el7_off" data-id="7" data-set="AminoAcid" data-type="" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label2 pw-left el-off7" style="top:65px;left:609px;"> <h2 class="pw_txtBox">Amino Acid Depletion<br>and Production of<br>Immunosuppressive<br>Metabolites</h2></div> <div id="el7_ct" class="pw-tooltip" data-id="7"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el8_gry" class="mdscmechanisms_all mdsc_pge2 pw-label el-gray8 pw-gray" style="top:170px;left:433px;"> PGE<sub>2</sub> </div> <div id="el8_off" data-id="8" data-set="PGE24" data-type="No Products Click" class="mdscmechanisms_all mdsc_pge2 pw-label el-off8" style="top:170px;left:433px;"> PGE<sub>2</sub></div> <div id="el8_ct" class="pw-tooltip" data-id="8"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/prostaglandin-e2-pge2">PGE2</a><br> </div> </div> <div id="el9_gry" class="mdscmechanisms_all mdsc_pge2 pw-sprite el-gray9 pw-gray" style="top:213.6000213623047px;left:451.00006103515625px;"> </div> <div id="el9_off" data-id="9" data-set="EP25" data-type="No Products Click" class="mdscmechanisms_all mdsc_pge2 pw-sprite el-off9" style="top:213.6000213623047px;left:451.00006103515625px;"> </div> <div id="el9_ct" class="pw-tooltip" data-id="9"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/ptger2">PTGER2</a><br> </div> </div> <div id="el10_gry" class="mdscmechanisms_all mdsc_pge2 pw-label el-gray10 pw-gray" style="top:242px;left:447px;"> EP2 </div> <div id="el10_off" data-id="10" data-set="EP25" data-type="No Products Click" class="mdscmechanisms_all mdsc_pge2 pw-label el-off10" style="top:242px;left:447px;"> EP2</div> <div id="el10_ct" class="pw-tooltip" data-id="10"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/ptger2">PTGER2</a><br> </div> </div> <div id="el11_gry" class="mdscmechanisms_all mdsc_pge2 pw-sprite el-gray11 pw-gray" style="top:226.00001525878906px;left:471.00006103515625px;"> </div> <div id="el11_off" data-id="11" data-set="EP46" data-type="No Products Click" class="mdscmechanisms_all mdsc_pge2 pw-sprite el-off11" style="top:226.00001525878906px;left:471.00006103515625px;"> </div> <div id="el11_ct" class="pw-tooltip" data-id="11"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/ptger4-ep4">PTGER4</a><br> </div> </div> <div id="el12_gry" class="mdscmechanisms_all mdsc_pge2 pw-label el-gray12 pw-gray" style="top:255px;left:468px;"> EP4 </div> <div id="el12_off" data-id="12" data-set="EP46" data-type="No Products Click" class="mdscmechanisms_all mdsc_pge2 pw-label el-off12" style="top:255px;left:468px;"> EP4</div> <div id="el12_ct" class="pw-tooltip" data-id="12"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/ptger4-ep4">PTGER4</a><br> </div> </div> <div id="el13_gry" class="mdscmechanisms_all mdsc_pge2 pw-sprite el-gray13 pw-gray" style="top:281.40000915527344px;left:345.00006103515625px;"> </div> <div id="el13_off" data-id="13" data-set="ARG17" data-type="No Products Click" class="mdscmechanisms_all mdsc_pge2 pw-sprite el-off13" style="top:281.40000915527344px;left:345.00006103515625px;"> </div> <div id="el13_ct" class="pw-tooltip" data-id="13"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/arginase-1-arg1">Arginase 1/ARG1</a><br> </div> </div> <div id="el14_gry" class="mdscmechanisms_all mdsc_pge2 pw-label el-gray14 pw-gray" style="top:292px;left:360px;"> ARG1 </div> <div id="el14_off" data-id="14" data-set="ARG17" data-type="No Products Click" class="mdscmechanisms_all mdsc_pge2 pw-label el-off14" style="top:292px;left:360px;"> ARG1</div> <div id="el14_ct" class="pw-tooltip" data-id="14"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/arginase-1-arg1">Arginase 1/ARG1</a><br> </div> </div> <div id="el15_gry" class="mdscmechanisms_all mdsc_inhibitiontcellhoming pw-label2 el-gray15 pw-gray" style="top:648px;left:1px;"> <h2 class="pw_txtBox">Inhibition of T Cell<br>Homing to the Lymph Nodes</h2> </div> <div id="el15_off" data-id="15" data-set="LowL-arginine8" data-type="" class="mdscmechanisms_all mdsc_inhibitiontcellhoming pw-label2 el-off15" style="top:648px;left:1px;"> <h2 class="pw_txtBox">Inhibition of T Cell<br>Homing to the Lymph Nodes</h2></div> <div id="el15_ct" class="pw-tooltip" data-id="15"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el16_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label el-gray16 pw-gray" style="top:117.61875343322754px;left:579.2000122070312px;"> Low L-arginine </div> <div id="el16_off" data-id="16" data-set="LowL-arginine8" data-type="No Products Click" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label el-off16" style="top:117.61875343322754px;left:579.2000122070312px;"> Low L-arginine</div> <div id="el16_ct" class="pw-tooltip" data-id="16"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/search?keywords=arginine&category=Small Molecules&common_name=Amino Acids">L-arginine</a><br> </div> </div> <div id="el17_gry" class="mdscmechanisms_all mdsc_s100a8_s100a9-mediatedaccumulation pw-label2 el-gray17 pw-gray" style="top:217px;left:115px;"> <h2 class="pw_txtBox">S100A8/A9-mediated<br>MDSC Accumulation</h2> </div> <div id="el17_off" data-id="17" data-set="S100A9-a" data-type="" class="mdscmechanisms_all mdsc_s100a8_s100a9-mediatedaccumulation pw-label2 el-off17" style="top:217px;left:115px;"> <h2 class="pw_txtBox">S100A8/A9-mediated<br>MDSC Accumulation</h2></div> <div id="el17_ct" class="pw-tooltip" data-id="17"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el18_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion mdsc_rosandrns pw-label el-gray18 pw-gray" style="top:258px;left:538px;"> L-arginine </div> <div id="el18_off" data-id="18" data-set="L-arginine9" data-type="No Products Click" class="mdscmechanisms_all mdsc_aminoaciddepletion mdsc_rosandrns pw-label el-off18" style="top:258px;left:538px;"> L-arginine</div> <div id="el18_ct" class="pw-tooltip" data-id="18"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=L-arginine">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el19_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion mdsc_rosandrns pw-sprite el-gray19 pw-gray" style="top:276.40000915527344px;left:518.9999389648438px;"> </div> <div id="el19_off" data-id="19" data-set="CAT-2B10" data-type="No Products Click" class="mdscmechanisms_all mdsc_aminoaciddepletion mdsc_rosandrns pw-sprite el-off19" style="top:276.40000915527344px;left:518.9999389648438px;"> </div> <div id="el19_ct" class="pw-tooltip" data-id="19"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=SLC7A2">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el20_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion mdsc_rosandrns pw-label el-gray20 pw-gray" style="top:271px;left:494px;"> CAT-2B </div> <div id="el20_off" data-id="20" data-set="CAT-2B10" data-type="No Products Click" class="mdscmechanisms_all mdsc_aminoaciddepletion mdsc_rosandrns pw-label el-off20" style="top:271px;left:494px;"> CAT-2B</div> <div id="el20_ct" class="pw-tooltip" data-id="20"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=SLC7A2">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el21_gry" class="mdscmechanisms_all mdsc_pge2 pw-label2 el-gray21 pw-gray" style="top:92px;left:123px;"> <h2 class="pw_txtBox">Production of PGE<sub>2</sub></h2> </div> <div id="el21_off" data-id="21" data-set="PGE" data-type="" class="mdscmechanisms_all mdsc_pge2 pw-label2 el-off21" style="top:92px;left:123px;"> <h2 class="pw_txtBox">Production of PGE<sub>2</sub></h2></div> <div id="el21_ct" class="pw-tooltip" data-id="21"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el22_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion mdsc_rosandrns pw-label el-gray22 pw-gray" style="top:295.61875915527344px;left:442.20001220703125px;"> L-arginine </div> <div id="el22_off" data-id="22" data-set="L-arginine11" data-type="No Products Click" class="mdscmechanisms_all mdsc_aminoaciddepletion mdsc_rosandrns pw-label el-off22" style="top:295.61875915527344px;left:442.20001220703125px;"> L-arginine</div> <div id="el22_ct" class="pw-tooltip" data-id="22"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=L-arginine">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el23_gry" class="mdscmechanisms_all mdsc_rosandrns pw-label2 el-gray23 pw-gray" style="top:479px;left:680px;"> <h2 class="pw_txtBox">Generation<br>of ROS<br>and RNS</h2> </div> <div id="el23_off" data-id="23" data-set="ROS-RNS-1" data-type="" class="mdscmechanisms_all mdsc_rosandrns pw-label2 el-off23" style="top:479px;left:680px;"> <h2 class="pw_txtBox">Generation<br>of ROS<br>and RNS</h2></div> <div id="el23_ct" class="pw-tooltip" data-id="23"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el24_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label el-gray24 pw-gray" style="top:135.4187526702881px;left:578.2000122070312px;"> Low L-cysteine </div> <div id="el24_off" data-id="24" data-set="LowL-cysteine12" data-type="No Products Click" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label el-off24" style="top:135.4187526702881px;left:578.2000122070312px;"> Low L-cysteine</div> <div id="el24_ct" class="pw-tooltip" data-id="24"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=L-cysteine">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el25_gry" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-label2 el-gray25 pw-gray" style="top:552px;left:624px;"> <h2 class="pw_txtBox">Direct Engagement of<br>T Cell Inhibitory and<br>Apoptosc Receptors</h2> </div> <div id="el25_off" data-id="25" data-set="TCellInhibitory" data-type="" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-label2 el-off25" style="top:552px;left:624px;"> <h2 class="pw_txtBox">Direct Engagement of<br>T Cell Inhibitory and<br>Apoptosc Receptors</h2></div> <div id="el25_ct" class="pw-tooltip" data-id="25"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el26_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label el-gray26 pw-gray" style="top:314.0187530517578px;left:460.20001220703125px;"> L-cystine </div> <div id="el26_off" data-id="26" data-set="L-cystine13" data-type="No Products Click" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label el-off26" style="top:314.0187530517578px;left:460.20001220703125px;"> L-cystine</div> <div id="el26_ct" class="pw-tooltip" data-id="26"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=L-cystine">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el27_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-sprite el-gray27 pw-gray" style="top:296.00001525878906px;left:526.9999389648438px;"> </div> <div id="el27_off" data-id="27" data-set="Xc-14" data-type="No Products Click" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-sprite el-off27" style="top:296.00001525878906px;left:526.9999389648438px;"> </div> <div id="el27_ct" class="pw-tooltip" data-id="27"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=SLC7A11">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el28_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label el-gray28 pw-gray" style="top:314px;left:554px;"> X<sub>c</sub>- </div> <div id="el28_off" data-id="28" data-set="Xc-14" data-type="No Products Click" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label el-off28" style="top:314px;left:554px;"> X<sub>c</sub>-</div> <div id="el28_ct" class="pw-tooltip" data-id="28"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=SLC7A11">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el29_gry" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label2 el-gray29 pw-gray" style="top:727px;left:442px;"> <h2 class="pw_txtBox">Production of Inhibitory Cytokines</h2> </div> <div id="el29_off" data-id="29" data-set="pro-Cytokines" data-type="" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label2 el-off29" style="top:727px;left:442px;"> <h2 class="pw_txtBox">Production of Inhibitory Cytokines</h2></div> <div id="el29_ct" class="pw-tooltip" data-id="29"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el30_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label el-gray30 pw-gray" style="top:282.21876525878906px;left:574.2000122070312px;"> L-cystine </div> <div id="el30_off" data-id="30" data-set="L-cystine15" data-type="No Products Click" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label el-off30" style="top:282.21876525878906px;left:574.2000122070312px;"> L-cystine</div> <div id="el30_ct" class="pw-tooltip" data-id="30"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=L-cystine">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el31_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-sprite el-gray31 pw-gray" style="top:327px;left:447px;"> </div> <div id="el31_off" data-id="31" data-set="IDO16" data-type="No Products Click" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-sprite el-off31" style="top:327px;left:447px;"> </div> <div id="el31_ct" class="pw-tooltip" data-id="31"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/indoleamine-2-3-dioxygenase-ido">IDO</a><br> </div> </div> <div id="el32_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label el-gray32 pw-gray" style="top:339px;left:467px;"> IDO </div> <div id="el32_off" data-id="32" data-set="IDO16" data-type="No Products Click" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label el-off32" style="top:339px;left:467px;"> IDO</div> <div id="el32_ct" class="pw-tooltip" data-id="32"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/indoleamine-2-3-dioxygenase-ido">IDO</a><br> </div> </div> <div id="el33_gry" class="mdscmechanisms_all mdsc_pge2 mdsc_aminoaciddepletion mdsc_rosandrns mdsc_tcellinhibitoryapoptoticreceptors mdsc_prodinhibitorycytokines mdsc_inhibitiontcellhoming mdsc_prodadenosine mdsc_s100a8_s100a9-mediatedaccumulation pw-label2 el-gray33 pw-gray" style="top:-450px;left:-450px;"> MDSC </div> <div id="el33_off" data-id="33" data-set="MDSC" data-type="" class="mdscmechanisms_all mdsc_pge2 mdsc_aminoaciddepletion mdsc_rosandrns mdsc_tcellinhibitoryapoptoticreceptors mdsc_prodinhibitorycytokines mdsc_inhibitiontcellhoming mdsc_prodadenosine mdsc_s100a8_s100a9-mediatedaccumulation pw-label2 el-off33" style="top:-450px;left:-450px;"> MDSC</div> <div id="el33_ct" class="pw-tooltip" data-id="33"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el34_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label el-gray34 pw-gray" style="top:318.21876525878906px;left:584.2000122070312px;"> Low L-tryptophan </div> <div id="el34_off" data-id="34" data-set="LowL-tryptophan17" data-type="No Products Click" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label el-off34" style="top:318.21876525878906px;left:584.2000122070312px;"> Low L-tryptophan</div> <div id="el34_ct" class="pw-tooltip" data-id="34"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=L-tryptophan">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el35_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-sprite el-gray35 pw-gray" style="top:-450px;left:-450px;"> </div> <div id="el35_off" data-id="35" data-set="Presenceofkynurenineandderivatives18" data-type="No Products Click" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-sprite el-off35" style="top:-450px;left:-450px;"> </div> <div id="el35_ct" class="pw-tooltip" data-id="35"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/products/l-kynurenine_4393">kynurenine</a><br> </div> </div> <div id="el36_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label el-gray36 pw-gray" style="top:334.61875915527344px;left:583.2000122070312px;"> Presence of kynurenine and derivatives </div> <div id="el36_off" data-id="36" data-set="Presenceofkynurenineandderivatives18" data-type="No Products Click" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label el-off36" style="top:334.61875915527344px;left:583.2000122070312px;"> Presence of kynurenine and derivatives</div> <div id="el36_ct" class="pw-tooltip" data-id="36"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/products/l-kynurenine_4393">kynurenine</a><br> </div> </div> <div id="el37_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-sprite el-gray37 pw-gray" style="top:313.59999084472656px;left:343.99993896484375px;"> </div> <div id="el37_off" data-id="37" data-set="ARG119" data-type="No Products Click" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-sprite el-off37" style="top:313.59999084472656px;left:343.99993896484375px;"> </div> <div id="el37_ct" class="pw-tooltip" data-id="37"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/arginase-1-arg1">Arginase 1/ARG1</a><br> </div> </div> <div id="el38_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label el-gray38 pw-gray" style="top:326px;left:358px;"> ARG1 </div> <div id="el38_off" data-id="38" data-set="ARG119" data-type="No Products Click" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label el-off38" style="top:326px;left:358px;"> ARG1</div> <div id="el38_ct" class="pw-tooltip" data-id="38"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/arginase-1-arg1">Arginase 1/ARG1</a><br> </div> </div> <div id="el39_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion mdsc_rosandrns pw-sprite el-gray39 pw-gray" style="top:344.00001525878906px;left:344.99993896484375px;"> </div> <div id="el39_off" data-id="39" data-set="iNOS20" data-type="No Products Click" class="mdscmechanisms_all mdsc_aminoaciddepletion mdsc_rosandrns pw-sprite el-off39" style="top:344.00001525878906px;left:344.99993896484375px;"> </div> <div id="el39_ct" class="pw-tooltip" data-id="39"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/inos">iNOS</a><br> </div> </div> <div id="el40_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion mdsc_rosandrns pw-label el-gray40 pw-gray" style="top:357px;left:361px;"> iNOS </div> <div id="el40_off" data-id="40" data-set="iNOS20" data-type="No Products Click" class="mdscmechanisms_all mdsc_aminoaciddepletion mdsc_rosandrns pw-label el-off40" style="top:357px;left:361px;"> iNOS</div> <div id="el40_ct" class="pw-tooltip" data-id="40"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/inos">iNOS</a><br> </div> </div> <div id="el41_gry" class="mdscmechanisms_all mdsc_rosandrns pw-sprite el-gray41 pw-gray" style="top:-450px;left:-450px;"> </div> <div id="el41_off" data-id="41" data-set="NO21" data-type="No Products Click" class="mdscmechanisms_all mdsc_rosandrns pw-sprite el-off41" style="top:-450px;left:-450px;"> </div> <div id="el41_ct" class="pw-tooltip" data-id="41"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/nitric-oxide">Nitric Oxide</a><br> </div> </div> <div id="el42_gry" class="mdscmechanisms_all mdsc_rosandrns pw-label el-gray42 pw-gray" style="top:362px;left:447px;"> NO </div> <div id="el42_off" data-id="42" data-set="NO21" data-type="No Products Click" class="mdscmechanisms_all mdsc_rosandrns pw-label el-off42" style="top:362px;left:447px;"> NO</div> <div id="el42_ct" class="pw-tooltip" data-id="42"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/nitric-oxide">Nitric Oxide</a><br> </div> </div> <div id="el43_gry" class="mdscmechanisms_all mdsc_rosandrns pw-sprite el-gray43 pw-gray" style="top:-450px;left:-450px;"> </div> <div id="el43_off" data-id="43" data-set="ONOO-22" data-type="No Products Click" class="mdscmechanisms_all mdsc_rosandrns pw-sprite el-off43" style="top:-450px;left:-450px;"> </div> <div id="el43_ct" class="pw-tooltip" data-id="43"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/peroxynitrite">Peroxynitrite</a><br> </div> </div> <div id="el44_gry" class="mdscmechanisms_all mdsc_rosandrns pw-label el-gray44 pw-gray" style="top:361.0187530517578px;left:500.20001220703125px;"> ONOO- </div> <div id="el44_off" data-id="44" data-set="ONOO-22" data-type="No Products Click" class="mdscmechanisms_all mdsc_rosandrns pw-label el-off44" style="top:361.0187530517578px;left:500.20001220703125px;"> ONOO-</div> <div id="el44_ct" class="pw-tooltip" data-id="44"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/peroxynitrite">Peroxynitrite</a><br> </div> </div> <div id="el45_gry" class="mdscmechanisms_all mdsc_rosandrns pw-sprite el-gray45 pw-gray" style="top:406.6000061035156px;left:348.99993896484375px;"> </div> <div id="el45_off" data-id="45" data-set="NADPHOxidase23" data-type="No Products Click" class="mdscmechanisms_all mdsc_rosandrns pw-sprite el-off45" style="top:406.6000061035156px;left:348.99993896484375px;"> </div> <div id="el45_ct" class="pw-tooltip" data-id="45"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/nadph-oxidase-inhibitors">NADPH Oxidase Inhibitors</a><br> </div> </div> <div id="el46_gry" class="mdscmechanisms_all mdsc_rosandrns pw-label el-gray46 pw-gray" style="top:383.61875915527344px;left:355.20001220703125px;"> NADPH<br>Oxidase </div> <div id="el46_off" data-id="46" data-set="NADPHOxidase23" data-type="No Products Click" class="mdscmechanisms_all mdsc_rosandrns pw-label el-off46" style="top:383.61875915527344px;left:355.20001220703125px;"> NADPH<br>Oxidase</div> <div id="el46_ct" class="pw-tooltip" data-id="46"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/nadph-oxidase-inhibitors">NADPH Oxidase Inhibitors</a><br> </div> </div> <div id="el47_gry" class="mdscmechanisms_all mdsc_rosandrns pw-sprite el-gray47 pw-gray" style="top:417.6000061035156px;left:348.99993896484375px;"> </div> <div id="el47_off" data-id="47" data-set="S100A824" data-type="No Products Click" class="mdscmechanisms_all mdsc_rosandrns pw-sprite el-off47" style="top:417.6000061035156px;left:348.99993896484375px;"> </div> <div id="el47_ct" class="pw-tooltip" data-id="47"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/s100a8">S100A8</a><br> </div> </div> <div id="el48_gry" class="mdscmechanisms_all mdsc_rosandrns pw-label el-gray48 pw-gray" style="top:442px;left:329px;"> S100A8 </div> <div id="el48_off" data-id="48" data-set="S100A824" data-type="No Products Click" class="mdscmechanisms_all mdsc_rosandrns pw-label el-off48" style="top:442px;left:329px;"> S100A8</div> <div id="el48_ct" class="pw-tooltip" data-id="48"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/s100a8">S100A8</a><br> </div> </div> <div id="el49_gry" class="mdscmechanisms_all mdsc_rosandrns pw-sprite el-gray49 pw-gray" style="top:417px;left:365.99993896484375px;"> </div> <div id="el49_off" data-id="49" data-set="S100A925" data-type="No Products Click" class="mdscmechanisms_all mdsc_rosandrns pw-sprite el-off49" style="top:417px;left:365.99993896484375px;"> </div> <div id="el49_ct" class="pw-tooltip" data-id="49"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/s100a9">S100A9</a><br> </div> </div> <div id="el50_gry" class="mdscmechanisms_all mdsc_rosandrns pw-label el-gray50 pw-gray" style="top:441px;left:385px;"> S100A9 </div> <div id="el50_off" data-id="50" data-set="S100A925" data-type="No Products Click" class="mdscmechanisms_all mdsc_rosandrns pw-label el-off50" style="top:441px;left:385px;"> S100A9</div> <div id="el50_ct" class="pw-tooltip" data-id="50"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/s100a9">S100A9</a><br> </div> </div> <div id="el51_gry" class="mdscmechanisms_all mdsc_rosandrns pw-sprite el-gray51 pw-gray" style="top:-450px;left:-450px;"> </div> <div id="el51_off" data-id="51" data-set="NOPeroxynitrite26" data-type="No Products Click" class="mdscmechanisms_all mdsc_rosandrns pw-sprite el-off51" style="top:-450px;left:-450px;"> </div> <div id="el51_ct" class="pw-tooltip" data-id="51"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/nitric-oxide">Nitric Oxide</a><br><a href="https://www.rndsystems.com/target/peroxynitrite">Peroxynitrite</a><br> </div> </div> <div id="el52_gry" class="mdscmechanisms_all mdsc_rosandrns pw-label el-gray52 pw-gray" style="top:382.21875762939453px;left:591.2000122070312px;"> NO Peroxynitrite </div> <div id="el52_off" data-id="52" data-set="NOPeroxynitrite26" data-type="No Products Click" class="mdscmechanisms_all mdsc_rosandrns pw-label el-off52" style="top:382.21875762939453px;left:591.2000122070312px;"> NO Peroxynitrite</div> <div id="el52_ct" class="pw-tooltip" data-id="52"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/nitric-oxide">Nitric Oxide</a><br><a href="https://www.rndsystems.com/target/peroxynitrite">Peroxynitrite</a><br> </div> </div> <div id="el53_gry" class="mdscmechanisms_all mdsc_rosandrns pw-sprite el-gray53 pw-gray" style="top:-450px;left:-450px;"> </div> <div id="el53_off" data-id="53" data-set="H2O227" data-type="No Products Click" class="mdscmechanisms_all mdsc_rosandrns pw-sprite el-off53" style="top:-450px;left:-450px;"> </div> <div id="el53_ct" class="pw-tooltip" data-id="53"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/fluorescent-cell-indicators-and-sensors">Fluorescent Cell Indicators and Sensors</a><br> </div> </div> <div id="el54_gry" class="mdscmechanisms_all mdsc_rosandrns pw-label el-gray54 pw-gray" style="top:409.0187454223633px;left:590.2000122070312px;"> H<sub>2</sub>O<sub>2</sub> </div> <div id="el54_off" data-id="54" data-set="H2O227" data-type="No Products Click" class="mdscmechanisms_all mdsc_rosandrns pw-label el-off54" style="top:409.0187454223633px;left:590.2000122070312px;"> H<sub>2</sub>O<sub>2</sub></div> <div id="el54_ct" class="pw-tooltip" data-id="54"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/fluorescent-cell-indicators-and-sensors">Fluorescent Hydrogen Peroxide Indicators</a><br> </div> </div> <div id="el55_gry" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-sprite el-gray55 pw-gray" style="top:436.00000762939453px;left:531.9999389648438px;"> </div> <div id="el55_off" data-id="55" data-set="Galectin-928-1" data-type="No Products Click" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-sprite el-off55" style="top:436.00000762939453px;left:531.9999389648438px;"> </div> <div id="el55_ct" class="pw-tooltip" data-id="55"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/galectin-9">Galectin-9</a><br> </div> </div> <div id="el56_gry" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-label el-gray56 pw-gray" style="top:425.6187515258789px;left:484.20001220703125px;"> Galectin-9 </div> <div id="el56_off" data-id="56" data-set="Galectin-928-1" data-type="No Products Click" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-label el-off56" style="top:425.6187515258789px;left:484.20001220703125px;"> Galectin-9</div> <div id="el56_ct" class="pw-tooltip" data-id="56"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/galectin-9">Galectin-9</a><br> </div> </div> <div id="el57_gry" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-sprite el-gray57 pw-gray" style="top:455.60001373291016px;left:567.9999389648438px;"> </div> <div id="el57_off" data-id="57" data-set="TIM-329" data-type="No Products Click" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-sprite el-off57" style="top:455.60001373291016px;left:567.9999389648438px;"> </div> <div id="el57_ct" class="pw-tooltip" data-id="57"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/tim-3">TIM-3</a><br> </div> </div> <div id="el58_gry" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-label el-gray58 pw-gray" style="top:468px;left:592px;"> TIM-3 </div> <div id="el58_off" data-id="58" data-set="TIM-329" data-type="No Products Click" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-label el-off58" style="top:468px;left:592px;"> TIM-3</div> <div id="el58_ct" class="pw-tooltip" data-id="58"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/tim-3">TIM-3</a><br> </div> </div> <div id="el59_gry" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-sprite el-gray59 pw-gray" style="top:452.2000198364258px;left:510.99993896484375px;"> </div> <div id="el59_off" data-id="59" data-set="FasL30" data-type="No Products Click" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-sprite el-off59" style="top:452.2000198364258px;left:510.99993896484375px;"> </div> <div id="el59_ct" class="pw-tooltip" data-id="59"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/fas-ligand-tnfsf6">Fas Ligand</a><br> </div> </div> <div id="el60_gry" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-label el-gray60 pw-gray" style="top:449px;left:490px;"> FasL </div> <div id="el60_off" data-id="60" data-set="FasL30" data-type="No Products Click" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-label el-off60" style="top:449px;left:490px;"> FasL</div> <div id="el60_ct" class="pw-tooltip" data-id="60"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/fas-ligand-tnfsf6">Fas Ligand</a><br> </div> </div> <div id="el61_gry" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-sprite el-gray61 pw-gray" style="top:477.60001373291016px;left:552.9999389648438px;"> </div> <div id="el61_off" data-id="61" data-set="Fas31" data-type="No Products Click" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-sprite el-off61" style="top:477.60001373291016px;left:552.9999389648438px;"> </div> <div id="el61_ct" class="pw-tooltip" data-id="61"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/fas-tnfrsf6-cd95">Fas</a><br> </div> </div> <div id="el62_gry" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-label el-gray62 pw-gray" style="top:507px;left:596px;"> Fas </div> <div id="el62_off" data-id="62" data-set="Fas31" data-type="No Products Click" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-label el-off62" style="top:507px;left:596px;"> Fas</div> <div id="el62_ct" class="pw-tooltip" data-id="62"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/fas-tnfrsf6-cd95">Fas</a><br> </div> </div> <div id="el63_gry" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-sprite el-gray63 pw-gray" style="top:477.2000198364258px;left:493.99993896484375px;"> </div> <div id="el63_off" data-id="63" data-set="PD-L132" data-type="No Products Click" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-sprite el-off63" style="top:477.2000198364258px;left:493.99993896484375px;"> </div> <div id="el63_ct" class="pw-tooltip" data-id="63"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/pd-l1-b7-h1">PD-L1</a><br> </div> </div> <div id="el64_gry" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-label el-gray64 pw-gray" style="top:472.6187515258789px;left:466.20001220703125px;"> PD-L1 </div> <div id="el64_off" data-id="64" data-set="PD-L132" data-type="No Products Click" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-label el-off64" style="top:472.6187515258789px;left:466.20001220703125px;"> PD-L1</div> <div id="el64_ct" class="pw-tooltip" data-id="64"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/pd-l1-b7-h1">PD-L1</a><br> </div> </div> <div id="el65_gry" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-sprite el-gray65 pw-gray" style="top:502.60001373291016px;left:548.9999389648438px;"> </div> <div id="el65_off" data-id="65" data-set="PD-133" data-type="No Products Click" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-sprite el-off65" style="top:502.60001373291016px;left:548.9999389648438px;"> </div> <div id="el65_ct" class="pw-tooltip" data-id="65"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/pd-1">PD-1</a><br> </div> </div> <div id="el66_gry" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-label el-gray66 pw-gray" style="top:521px;left:542px;"> PD-1 </div> <div id="el66_off" data-id="66" data-set="PD-133" data-type="No Products Click" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-label el-off66" style="top:521px;left:542px;"> PD-1</div> <div id="el66_ct" class="pw-tooltip" data-id="66"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/pd-1">PD-1</a><br> </div> </div> <div id="el67_gry" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-sprite el-gray67 pw-gray" style="top:508.00000762939453px;left:429.99993896484375px;"> </div> <div id="el67_off" data-id="67" data-set="CCL234" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-sprite el-off67" style="top:508.00000762939453px;left:429.99993896484375px;"> </div> <div id="el67_ct" class="pw-tooltip" data-id="67"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/ccl2-je-mcp-1">CCL2</a><br> </div> </div> <div id="el68_gry" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label el-gray68 pw-gray" style="top:497.4187774658203px;left:424.20001220703125px;"> CCL2 </div> <div id="el68_off" data-id="68" data-set="CCL234" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label el-off68" style="top:497.4187774658203px;left:424.20001220703125px;"> CCL2</div> <div id="el68_ct" class="pw-tooltip" data-id="68"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/ccl2-je-mcp-1">CCL2</a><br> </div> </div> <div id="el69_gry" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-sprite el-gray69 pw-gray" style="top:567.4000091552734px;left:435.99993896484375px;"> </div> <div id="el69_off" data-id="69" data-set="TGF-beta35" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-sprite el-off69" style="top:567.4000091552734px;left:435.99993896484375px;"> </div> <div id="el69_ct" class="pw-tooltip" data-id="69"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/tgf-beta-1">TGF-beta 1</a><br> </div> </div> <div id="el70_gry" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label el-gray70 pw-gray" style="top:560.0187530517578px;left:458.20001220703125px;"> TGF-beta </div> <div id="el70_off" data-id="70" data-set="TGF-beta35" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label el-off70" style="top:560.0187530517578px;left:458.20001220703125px;"> TGF-beta</div> <div id="el70_ct" class="pw-tooltip" data-id="70"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/tgf-beta-1">TGF-beta 1</a><br> </div> </div> <div id="el71_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-label2 el-gray71 pw-gray" style="top:537px;left:109px;"> <h2 class="pw_txtBox">Production of<br>Extracellular<br>Adenosine</h2> </div> <div id="el71_off" data-id="71" data-set="e-Adenosine" data-type="" class="mdscmechanisms_all mdsc_prodadenosine pw-label2 el-off71" style="top:537px;left:109px;"> <h2 class="pw_txtBox">Production of<br>Extracellular<br>Adenosine</h2></div> <div id="el71_ct" class="pw-tooltip" data-id="71"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el72_gry" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label el-gray72 pw-gray" style="top:-450px;left:-450px;"> TGF-beta </div> <div id="el72_off" data-id="72" data-set="TGF-beta36" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label el-off72" style="top:-450px;left:-450px;"> TGF-beta</div> <div id="el72_ct" class="pw-tooltip" data-id="72"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/tgf-beta-1">TGF-beta 1</a><br> </div> </div> <div id="el73_gry" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-sprite el-gray73 pw-gray" style="top:523.8000030517578px;left:345.99993896484375px;"> </div> <div id="el73_off" data-id="73" data-set="IL-10TGF-beta37" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-sprite el-off73" style="top:523.8000030517578px;left:345.99993896484375px;"> </div> <div id="el73_ct" class="pw-tooltip" data-id="73"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/il-10">IL-10</a><br><a href="https://www.rndsystems.com/target/tgf-beta-1">TGF-beta 1</a><br> </div> </div> <div id="el74_gry" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label el-gray74 pw-gray" style="top:510px;left:320px;"> IL-10, TGF-beta </div> <div id="el74_off" data-id="74" data-set="IL-10TGF-beta37" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label el-off74" style="top:510px;left:320px;"> IL-10, TGF-beta</div> <div id="el74_ct" class="pw-tooltip" data-id="74"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/il-10">IL-10</a><br><a href="https://www.rndsystems.com/target/tgf-beta-1">TGF-beta 1</a><br> </div> </div> <div id="el75_gry" class="mdscmechanisms_all mdsc_inhibitiontcellhoming pw-sprite el-gray75 pw-gray" style="top:483.00003814697266px;left:259.5999755859375px;"> </div> <div id="el75_off" data-id="75" data-set="ADAM1738" data-type="No Products Click" class="mdscmechanisms_all mdsc_inhibitiontcellhoming pw-sprite el-off75" style="top:483.00003814697266px;left:259.5999755859375px;"> </div> <div id="el75_ct" class="pw-tooltip" data-id="75"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/tace-adam17">TACE/ADAM17</a><br> </div> </div> <div id="el76_gry" class="mdscmechanisms_all mdsc_inhibitiontcellhoming pw-label el-gray76 pw-gray" style="top:478.41876792907715px;left:293.79998779296875px;"> ADAM17 </div> <div id="el76_off" data-id="76" data-set="ADAM1738" data-type="No Products Click" class="mdscmechanisms_all mdsc_inhibitiontcellhoming pw-label el-off76" style="top:478.41876792907715px;left:293.79998779296875px;"> ADAM17</div> <div id="el76_ct" class="pw-tooltip" data-id="76"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/tace-adam17">TACE/ADAM17</a><br> </div> </div> <div id="el77_gry" class="mdscmechanisms_all mdsc_inhibitiontcellhoming pw-sprite el-gray77 pw-gray" style="top:677.3999996185303px;left:111.5999755859375px;"> </div> <div id="el77_off" data-id="77" data-set="L-Selectin39" data-type="No Products Click" class="mdscmechanisms_all mdsc_inhibitiontcellhoming pw-sprite el-off77" style="top:677.3999996185303px;left:111.5999755859375px;"> </div> <div id="el77_ct" class="pw-tooltip" data-id="77"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/l-selectin-cd62l">L-Selectin</a><br> </div> </div> <div id="el78_gry" class="mdscmechanisms_all mdsc_inhibitiontcellhoming pw-label el-gray78 pw-gray" style="top:706.8187637329102px;left:136.79998779296875px;"> L-Selectin </div> <div id="el78_off" data-id="78" data-set="L-Selectin39" data-type="No Products Click" class="mdscmechanisms_all mdsc_inhibitiontcellhoming pw-label el-off78" style="top:706.8187637329102px;left:136.79998779296875px;"> L-Selectin</div> <div id="el78_ct" class="pw-tooltip" data-id="78"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/l-selectin-cd62l">L-Selectin</a><br> </div> </div> <div id="el79_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-gray79 pw-gray" style="top:395.79999351501465px;left:206.5999755859375px;"> </div> <div id="el79_off" data-id="79" data-set="CD3940" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-off79" style="top:395.79999351501465px;left:206.5999755859375px;"> </div> <div id="el79_ct" class="pw-tooltip" data-id="79"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/cd39-entpd1">CD39</a><br> </div> </div> <div id="el80_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-gray80 pw-gray" style="top:422.2187557220459px;left:230.79998779296875px;"> CD39 </div> <div id="el80_off" data-id="80" data-set="CD3940" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-off80" style="top:422.2187557220459px;left:230.79998779296875px;"> CD39</div> <div id="el80_ct" class="pw-tooltip" data-id="80"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/cd39-entpd1">CD39</a><br> </div> </div> <div id="el81_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-gray81 pw-gray" style="top:354.20001792907715px;left:202.5999755859375px;"> </div> <div id="el81_off" data-id="81" data-set="CD7341" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-off81" style="top:354.20001792907715px;left:202.5999755859375px;"> </div> <div id="el81_ct" class="pw-tooltip" data-id="81"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/5-nucleotidase-cd73">5'-Nucleotidase</a><br> </div> </div> <div id="el82_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-gray82 pw-gray" style="top:378.6187496185303px;left:228.79998779296875px;"> CD73 </div> <div id="el82_off" data-id="82" data-set="CD7341" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-off82" style="top:378.6187496185303px;left:228.79998779296875px;"> CD73</div> <div id="el82_ct" class="pw-tooltip" data-id="82"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/5-nucleotidase-cd73">5'-Nucleotidase</a><br> </div> </div> <div id="el83_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-gray83 pw-gray" style="top:-450px;left:-450px;"> </div> <div id="el83_off" data-id="83" data-set="ATP42" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-off83" style="top:-450px;left:-450px;"> </div> <div id="el83_ct" class="pw-tooltip" data-id="83"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="Product Suggestion Box">ATP</a><br> </div> </div> <div id="el84_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-gray84 pw-gray" style="top:428px;left:184px;"> ATP </div> <div id="el84_off" data-id="84" data-set="ATP42" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-off84" style="top:428px;left:184px;"> ATP</div> <div id="el84_ct" class="pw-tooltip" data-id="84"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=ATP">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el85_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-gray85 pw-gray" style="top:-450px;left:-450px;"> </div> <div id="el85_off" data-id="85" data-set="AMP43" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-off85" style="top:-450px;left:-450px;"> </div> <div id="el85_ct" class="pw-tooltip" data-id="85"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="Product Suggestion Box">AMP</a><br> </div> </div> <div id="el86_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-gray86 pw-gray" style="top:377.2187557220459px;left:169.79998779296875px;"> AMP </div> <div id="el86_off" data-id="86" data-set="AMP43" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-off86" style="top:377.2187557220459px;left:169.79998779296875px;"> AMP</div> <div id="el86_ct" class="pw-tooltip" data-id="86"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=AMP">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el87_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-gray87 pw-gray" style="top:313.20001792907715px;left:123.5999755859375px;"> </div> <div id="el87_off" data-id="87" data-set="Adenosine44" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-off87" style="top:313.20001792907715px;left:123.5999755859375px;"> </div> <div id="el87_ct" class="pw-tooltip" data-id="87"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="Product Suggestion Box">Adenosine</a><br> </div> </div> <div id="el88_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-gray88 pw-gray" style="top:339px;left:119px;"> Adenosine </div> <div id="el88_off" data-id="88" data-set="Adenosine44" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-off88" style="top:339px;left:119px;"> Adenosine</div> <div id="el88_ct" class="pw-tooltip" data-id="88"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=Adenosine">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el89_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-gray89 pw-gray" style="top:175.8000087738037px;left:37.5999755859375px;"> </div> <div id="el89_off" data-id="89" data-set="A2A2BR45" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-off89" style="top:175.8000087738037px;left:37.5999755859375px;"> </div> <div id="el89_ct" class="pw-tooltip" data-id="89"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/adenosine-a2ar">Adenosine A2aR</a><br><a href="https://www.rndsystems.com/target/adenosine-a2b-r">Adenosine A2b R</a><br> </div> </div> <div id="el90_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-gray90 pw-gray" style="top:162.2187557220459px;left:19.79998779296875px;"> A<sub>2A/2B</sub> R </div> <div id="el90_off" data-id="90" data-set="A2A2BR45" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-off90" style="top:162.2187557220459px;left:19.79998779296875px;"> A<sub>2A/2B</sub> R</div> <div id="el90_ct" class="pw-tooltip" data-id="90"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/adenosine-a2ar">Adenosine A2aR</a><br><a href="https://www.rndsystems.com/target/adenosine-a2b-r">Adenosine A2b R</a><br> </div> </div> <div id="el91_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-gray91 pw-gray" style="top:241.2000026702881px;left:0.5999755859375px;"> </div> <div id="el91_off" data-id="91" data-set="A2AR46" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-off91" style="top:241.2000026702881px;left:0.5999755859375px;"> </div> <div id="el91_ct" class="pw-tooltip" data-id="91"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/adenosine-a2ar">Adenosine A2aR</a><br> </div> </div> <div id="el92_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-gray92 pw-gray" style="top:234px;left:3px;"> A<sub>2A</sub> R </div> <div id="el92_off" data-id="92" data-set="A2AR46" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-off92" style="top:234px;left:3px;"> A<sub>2A</sub> R</div> <div id="el92_ct" class="pw-tooltip" data-id="92"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/adenosine-a2ar">Adenosine A2aR</a><br> </div> </div> <div id="el93_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-gray93 pw-gray" style="top:367.6000118255615px;left:-3.4000244140625px;"> </div> <div id="el93_off" data-id="93" data-set="A2AR47" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-off93" style="top:367.6000118255615px;left:-3.4000244140625px;"> </div> <div id="el93_ct" class="pw-tooltip" data-id="93"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/adenosine-a2ar">Adenosine A2aR</a><br> </div> </div> <div id="el94_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-gray94 pw-gray" style="top:363px;left:10px;"> A<sub>2A</sub> R </div> <div id="el94_off" data-id="94" data-set="A2AR47" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-off94" style="top:363px;left:10px;"> A<sub>2A</sub> R</div> <div id="el94_ct" class="pw-tooltip" data-id="94"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/adenosine-a2ar">Adenosine A2aR</a><br> </div> </div> <div id="el95_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-gray95 pw-gray" style="top:466.60001373291016px;left:-5px;"> </div> <div id="el95_off" data-id="95" data-set="A2AR48" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-off95" style="top:466.60001373291016px;left:-5px;"> </div> <div id="el95_ct" class="pw-tooltip" data-id="95"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/adenosine-a2ar">Adenosine A2aR</a><br> </div> </div> <div id="el96_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-gray96 pw-gray" style="top:461px;left:11px;"> A<sub>2A</sub> R </div> <div id="el96_off" data-id="96" data-set="A2AR48" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-off96" style="top:461px;left:11px;"> A<sub>2A</sub> R</div> <div id="el96_ct" class="pw-tooltip" data-id="96"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/adenosine-a2ar">Adenosine A2aR</a><br> </div> </div> <div id="el97_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-gray97 pw-gray" style="top:469.00003814697266px;left:125px;"> </div> <div id="el97_off" data-id="97" data-set="A2AR49" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-off97" style="top:469.00003814697266px;left:125px;"> </div> <div id="el97_ct" class="pw-tooltip" data-id="97"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/adenosine-a2ar">Adenosine A2aR</a><br> </div> </div> <div id="el98_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-gray98 pw-gray" style="top:464px;left:141px;"> A<sub>2A</sub> R </div> <div id="el98_off" data-id="98" data-set="A2AR49" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-off98" style="top:464px;left:141px;"> A<sub>2A</sub> R</div> <div id="el98_ct" class="pw-tooltip" data-id="98"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/adenosine-a2ar">Adenosine A2aR</a><br> </div> </div> <div id="el99_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-gray99 pw-gray" style="top:544.4000015258789px;left:26px;"> </div> <div id="el99_off" data-id="99" data-set="A2A2BR50" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-sprite el-off99" style="top:544.4000015258789px;left:26px;"> </div> <div id="el99_ct" class="pw-tooltip" data-id="99"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/adenosine-a2ar">Adenosine A2aR</a><br><a href="https://www.rndsystems.com/target/adenosine-a2b-r">Adenosine A2b R</a><br> </div> </div> <div id="el100_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-gray100 pw-gray" style="top:538.8187637329102px;left:14.20001220703125px;"> A<sub>2A/2B</sub> R </div> <div id="el100_off" data-id="100" data-set="A2A2BR50" data-type="No Products Click" class="mdscmechanisms_all mdsc_prodadenosine pw-label el-off100" style="top:538.8187637329102px;left:14.20001220703125px;"> A<sub>2A/2B</sub> R</div> <div id="el100_ct" class="pw-tooltip" data-id="100"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/adenosine-a2ar">Adenosine A2aR</a><br><a href="https://www.rndsystems.com/target/adenosine-a2b-r">Adenosine A2b R</a><br> </div> </div> <div id="el101_gry" class="mdscmechanisms_all mdsc_s100a8_s100a9-mediatedaccumulation pw-sprite el-gray101 pw-gray" style="top:247.4000015258789px;left:185px;"> </div> <div id="el101_off" data-id="101" data-set="S100A8A951" data-type="No Products Click" class="mdscmechanisms_all mdsc_s100a8_s100a9-mediatedaccumulation pw-sprite el-off101" style="top:247.4000015258789px;left:185px;"> </div> <div id="el101_ct" class="pw-tooltip" data-id="101"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/s100a8-s100a9-heterodimer">S100A8/S100A9 Heterodimer</a><br> </div> </div> <div id="el102_gry" class="mdscmechanisms_all mdsc_s100a8_s100a9-mediatedaccumulation pw-label el-gray102 pw-gray" style="top:247.41876983642578px;left:125.20001220703125px;"> S100A8/A9 </div> <div id="el102_off" data-id="102" data-set="S100A8A951" data-type="No Products Click" class="mdscmechanisms_all mdsc_s100a8_s100a9-mediatedaccumulation pw-label el-off102" style="top:247.41876983642578px;left:125.20001220703125px;"> S100A8/A9</div> <div id="el102_ct" class="pw-tooltip" data-id="102"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/s100a8-s100a9-heterodimer">S100A8/S100A9 Heterodimer</a><br> </div> </div> <div id="el103_gry" class="mdscmechanisms_all mdsc_s100a8_s100a9-mediatedaccumulation pw-sprite el-gray103 pw-gray" style="top:259.2000198364258px;left:198px;"> </div> <div id="el103_off" data-id="103" data-set="RAGE52" data-type="No Products Click" class="mdscmechanisms_all mdsc_s100a8_s100a9-mediatedaccumulation pw-sprite el-off103" style="top:259.2000198364258px;left:198px;"> </div> <div id="el103_ct" class="pw-tooltip" data-id="103"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/rage-ager">RAGE</a><br> </div> </div> <div id="el104_gry" class="mdscmechanisms_all mdsc_s100a8_s100a9-mediatedaccumulation pw-label el-gray104 pw-gray" style="top:295px;left:233px;"> RAGE </div> <div id="el104_off" data-id="104" data-set="RAGE52" data-type="No Products Click" class="mdscmechanisms_all mdsc_s100a8_s100a9-mediatedaccumulation pw-label el-off104" style="top:295px;left:233px;"> RAGE</div> <div id="el104_ct" class="pw-tooltip" data-id="104"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/rage-ager">RAGE</a><br> </div> </div> <div id="el105_gry" class="mdscmechanisms_all mdsc_s100a8_s100a9-mediatedaccumulation pw-sprite el-gray105 pw-gray" style="top:264.00000762939453px;left:261px;"> </div> <div id="el105_off" data-id="105" data-set="S100A8A953" data-type="No Products Click" class="mdscmechanisms_all mdsc_s100a8_s100a9-mediatedaccumulation pw-sprite el-off105" style="top:264.00000762939453px;left:261px;"> </div> <div id="el105_ct" class="pw-tooltip" data-id="105"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/s100a8-s100a9-heterodimer">S100A8/S100A9 Heterodimer</a><br> </div> </div> <div id="el106_gry" class="mdscmechanisms_all mdsc_s100a8_s100a9-mediatedaccumulation pw-label el-gray106 pw-gray" style="top:290.0187454223633px;left:279.20001220703125px;"> S100A8/A9 </div> <div id="el106_off" data-id="106" data-set="S100A8A953" data-type="No Products Click" class="mdscmechanisms_all mdsc_s100a8_s100a9-mediatedaccumulation pw-label el-off106" style="top:290.0187454223633px;left:279.20001220703125px;"> S100A8/A9</div> <div id="el106_ct" class="pw-tooltip" data-id="106"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="https://www.rndsystems.com/target/s100a8-s100a9-heterodimer">S100A8/S100A9 Heterodimer</a><br> </div> </div> <div id="el107_gry" class="mdscmechanisms_all mdsc_pge2 pw-label2 pw-center el-gray107 pw-gray" style="top:24px;left:215px;"> Natural<br>Killer Cells </div> <div id="el107_off" data-id="107" data-set="NaturalKillerCells" data-type="" class="mdscmechanisms_all mdsc_pge2 pw-label2 pw-center el-off107" style="top:24px;left:215px;"> Natural<br>Killer Cells</div> <div id="el107_ct" class="pw-tooltip" data-id="107"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el108_gry" class="mdscmechanisms_all mdsc_pge2 pw-label2 pw-center el-gray108 pw-gray" style="top:57.618751525878906px;left:350.20001220703125px;"> Effector<br>T Cells </div> <div id="el108_off" data-id="108" data-set="EffectorTCells" data-type="" class="mdscmechanisms_all mdsc_pge2 pw-label2 pw-center el-off108" style="top:57.618751525878906px;left:350.20001220703125px;"> Effector<br>T Cells</div> <div id="el108_ct" class="pw-tooltip" data-id="108"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el109_gry" class="mdscmechanisms_all mdsc_pge2 pw-label2 el-gray109 pw-gray" style="top:25.018753051757812px;left:400.20001220703125px;"> Dendritic Cells </div> <div id="el109_off" data-id="109" data-set="DendriticCells" data-type="" class="mdscmechanisms_all mdsc_pge2 pw-label2 el-off109" style="top:25.018753051757812px;left:400.20001220703125px;"> Dendritic Cells</div> <div id="el109_ct" class="pw-tooltip" data-id="109"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el110_gry" class="mdscmechanisms_all mdsc_pge2 pw-label2 el-gray110 pw-gray" style="top:52px;left:485px;"> Tregs </div> <div id="el110_off" data-id="110" data-set="Tregs" data-type="" class="mdscmechanisms_all mdsc_pge2 pw-label2 el-off110" style="top:52px;left:485px;"> Tregs</div> <div id="el110_ct" class="pw-tooltip" data-id="110"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el111_gry" class="mdscmechanisms_all mdsc_pge2 pw-label2 el-gray111 pw-gray" style="top:41.818756103515625px;left:553.2000122070312px;"> MDSCs </div> <div id="el111_off" data-id="111" data-set="MDSCs" data-type="" class="mdscmechanisms_all mdsc_pge2 pw-label2 el-off111" style="top:41.818756103515625px;left:553.2000122070312px;"> MDSCs</div> <div id="el111_ct" class="pw-tooltip" data-id="111"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el112_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label2 el-gray112 pw-gray" style="top:167.2187557220459px;left:705.2000122070312px;"> T Cells </div> <div id="el112_off" data-id="112" data-set="TCells" data-type="" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label2 el-off112" style="top:167.2187557220459px;left:705.2000122070312px;"> T Cells</div> <div id="el112_ct" class="pw-tooltip" data-id="112"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el113_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label2 el-gray113 pw-gray" style="top:216px;left:681px;"> Tregs </div> <div id="el113_off" data-id="113" data-set="Tregs" data-type="" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label2 el-off113" style="top:216px;left:681px;"> Tregs</div> <div id="el113_ct" class="pw-tooltip" data-id="113"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el114_gry" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label2 pw-center el-gray114 pw-gray" style="top:263.01873779296875px;left:696.2000122070312px;"> Natural Killer Cells </div> <div id="el114_off" data-id="114" data-set="NaturalKillerCells" data-type="" class="mdscmechanisms_all mdsc_aminoaciddepletion pw-label2 pw-center el-off114" style="top:263.01873779296875px;left:696.2000122070312px;"> Natural Killer Cells</div> <div id="el114_ct" class="pw-tooltip" data-id="114"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el115_gry" class="mdscmechanisms_all mdsc_rosandrns pw-label2 el-gray115 pw-gray" style="top:434.4187316894531px;left:701.2000122070312px;"> T Cells </div> <div id="el115_off" data-id="115" data-set="TCells" data-type="" class="mdscmechanisms_all mdsc_rosandrns pw-label2 el-off115" style="top:434.4187316894531px;left:701.2000122070312px;"> T Cells</div> <div id="el115_ct" class="pw-tooltip" data-id="115"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el116_gry" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-label2 el-gray116 pw-gray" style="top:492.81876373291016px;left:624.2000122070312px;"> Effector<br>T Cells </div> <div id="el116_off" data-id="116" data-set="EffectorTCells" data-type="" class="mdscmechanisms_all mdsc_tcellinhibitoryapoptoticreceptors pw-label2 el-off116" style="top:492.81876373291016px;left:624.2000122070312px;"> Effector<br>T Cells</div> <div id="el116_ct" class="pw-tooltip" data-id="116"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el117_gry" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label2 el-gray117 pw-gray" style="top:595.2187843322754px;left:528.2000122070312px;"> M2<br>Macrophages </div> <div id="el117_off" data-id="117" data-set="M2Macrophages" data-type="" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label2 el-off117" style="top:595.2187843322754px;left:528.2000122070312px;"> M2<br>Macrophages</div> <div id="el117_ct" class="pw-tooltip" data-id="117"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el118_gry" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label2 el-gray118 pw-gray" style="top:667.6125259399414px;left:482.20001220703125px;"> CD8<sup>+</sup><br>T Cells </div> <div id="el118_off" data-id="118" data-set="CD8-TCells" data-type="" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label2 el-off118" style="top:667.6125259399414px;left:482.20001220703125px;"> CD8<sup>+</sup><br>T Cells</div> <div id="el118_ct" class="pw-tooltip" data-id="118"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el119_gry" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label2 pw-center el-gray119 pw-gray" style="top:665.0187759399414px;left:419.20001220703125px;"> Natural<br>Killer<br>Cells </div> <div id="el119_off" data-id="119" data-set="NaturalKillerCells" data-type="" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label2 pw-center el-off119" style="top:665.0187759399414px;left:419.20001220703125px;"> Natural<br>Killer<br>Cells</div> <div id="el119_ct" class="pw-tooltip" data-id="119"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el120_gry" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label2 el-gray120 pw-gray" style="top:613.4187393188477px;left:317.20001220703125px;"> Effector<br>T Cells </div> <div id="el120_off" data-id="120" data-set="EffectorTCells" data-type="" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label2 el-off120" style="top:613.4187393188477px;left:317.20001220703125px;"> Effector<br>T Cells</div> <div id="el120_ct" class="pw-tooltip" data-id="120"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el121_gry" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label2 el-gray121 pw-gray" style="top:705.8187637329102px;left:288.20001220703125px;"> Dendritic<br>Cells </div> <div id="el121_off" data-id="121" data-set="DendriticCells" data-type="" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label2 el-off121" style="top:705.8187637329102px;left:288.20001220703125px;"> Dendritic<br>Cells</div> <div id="el121_ct" class="pw-tooltip" data-id="121"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el122_gry" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label2 el-gray122 pw-gray" style="top:607.2187881469727px;left:233.20001220703125px;"> Tregs </div> <div id="el122_off" data-id="122" data-set="Tregs" data-type="" class="mdscmechanisms_all mdsc_prodinhibitorycytokines pw-label2 el-off122" style="top:607.2187881469727px;left:233.20001220703125px;"> Tregs</div> <div id="el122_ct" class="pw-tooltip" data-id="122"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el123_gry" class="mdscmechanisms_all mdsc_inhibitiontcellhoming pw-label2 el-gray123 pw-gray" style="top:687.6187515258789px;left:55.20001220703125px;"> Naive CD4<sup>+</sup><br>and CD8<sup>+</sup><br> T Cells </div> <div id="el123_off" data-id="123" data-set="Na-FDA5-CD4-andCD8-TCells" data-type="" class="mdscmechanisms_all mdsc_inhibitiontcellhoming pw-label2 el-off123" style="top:687.6187515258789px;left:55.20001220703125px;"> Naive CD4<sup>+</sup><br>and CD8<sup>+</sup><br> T Cells</div> <div id="el123_ct" class="pw-tooltip" data-id="123"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el124_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-label2 el-gray124 pw-gray" style="top:492.0187454223633px;left:143.20001220703125px;"> Tregs </div> <div id="el124_off" data-id="124" data-set="Tregs" data-type="" class="mdscmechanisms_all mdsc_prodadenosine pw-label2 el-off124" style="top:492.0187454223633px;left:143.20001220703125px;"> Tregs</div> <div id="el124_ct" class="pw-tooltip" data-id="124"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el125_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-label2 pw-center el-gray125 pw-gray" style="top:563px;left:30px;"> M2<br>Macrophages </div> <div id="el125_off" data-id="125" data-set="M2Macrophages" data-type="" class="mdscmechanisms_all mdsc_prodadenosine pw-label2 pw-center el-off125" style="top:563px;left:30px;"> M2<br>Macrophages</div> <div id="el125_ct" class="pw-tooltip" data-id="125"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el126_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-label2 el-gray126 pw-gray" style="top:485.81876373291016px;left:18.20001220703125px;"> NKT<br>Cells </div> <div id="el126_off" data-id="126" data-set="NKTCells" data-type="" class="mdscmechanisms_all mdsc_prodadenosine pw-label2 el-off126" style="top:485.81876373291016px;left:18.20001220703125px;"> NKT<br>Cells</div> <div id="el126_ct" class="pw-tooltip" data-id="126"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el127_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-label2 pw-center el-gray127 pw-gray" style="top:395px;left:13px;"> Natural<br>Killer Cells </div> <div id="el127_off" data-id="127" data-set="NaturalKillerCells" data-type="" class="mdscmechanisms_all mdsc_prodadenosine pw-label2 pw-center el-off127" style="top:395px;left:13px;"> Natural<br>Killer Cells</div> <div id="el127_ct" class="pw-tooltip" data-id="127"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el128_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-label2 el-gray128 pw-gray" style="top:267px;left:15px;"> Effector<br>T Cells </div> <div id="el128_off" data-id="128" data-set="EffectorTCells" data-type="" class="mdscmechanisms_all mdsc_prodadenosine pw-label2 el-off128" style="top:267px;left:15px;"> Effector<br>T Cells</div> <div id="el128_ct" class="pw-tooltip" data-id="128"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el129_gry" class="mdscmechanisms_all mdsc_prodadenosine pw-label2 el-gray129 pw-gray" style="top:198.0187530517578px;left:49.20001220703125px;"> Dendritic<br>Cells </div> <div id="el129_off" data-id="129" data-set="DendriticCells" data-type="" class="mdscmechanisms_all mdsc_prodadenosine pw-label2 el-off129" style="top:198.0187530517578px;left:49.20001220703125px;"> Dendritic<br>Cells</div> <div id="el129_ct" class="pw-tooltip" data-id="129"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el130_gry" class="mdscmechanisms_all mdsc_pge2 pw-label2 pw-right el-gray130 pw-gray" style="top:202px;left:236px;"> Tumor-derived<br>Factors </div> <div id="el130_off" data-id="130" data-set="Tumor-derivedFactors" data-type="" class="mdscmechanisms_all mdsc_pge2 pw-label2 pw-right el-off130" style="top:202px;left:236px;"> Tumor-derived<br>Factors</div> <div id="el130_ct" class="pw-tooltip" data-id="130"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el131_gry" class="mdscmechanisms_all mdsc_rosandrns pw-label2 el-gray131 pw-gray" style="top:393.81876373291016px;left:441.20001220703125px;"> O<sub>2</sub>- </div> <div id="el131_off" data-id="131" data-set="O2" data-type="" class="mdscmechanisms_all mdsc_rosandrns pw-label2 el-off131" style="top:393.81876373291016px;left:441.20001220703125px;"> O<sub>2</sub>-</div> <div id="el131_ct" class="pw-tooltip" data-id="131"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el132_gry" class="mdscmechanisms_all mdsc_rosandrns pw-label2 el-gray132 pw-gray" style="top:431px;left:449px;"> H<sub>2</sub>0 </div> <div id="el132_off" data-id="132" data-set="H20" data-type="" class="mdscmechanisms_all mdsc_rosandrns pw-label2 el-off132" style="top:431px;left:449px;"> H<sub>2</sub>0</div> <div id="el132_ct" class="pw-tooltip" data-id="132"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el133_off" data-id="133" data-set="EffectsofIL-38Box" data-type="" class="mdsc_pge2 pw-label2 pw-left pw-none el-off133" style="top:324px;left:348px;"> <div class="pw_txtBox" style="width:363px;text-align: left;"><h4 style="border-bottom: solid 1px #000;margin-bottom:8px;padding-bottom:0px;">Production of PGE<sub>2</sub></h4> <strong>Natural Killer Cells</strong><br> • Inhibits IFN-gamma secretion<br> • Inhibits cytolytic activity<br> <strong>Effector T Cells </strong><br> • Inhibits IL-2 synthesis and IL-2 R expression<br> • Inhibits Th1 differentiation<br> <strong>Dendritic Cells</strong><br> • Inhibits IL-2 synthesis and IL-2 R expression<br> <strong>Tregs</strong><br> • Promotes differentiation and accumulation<br> <strong>MDSCs</strong><br> • Promotes expansion<br> • ↑ Suppressive activity </div> </div> <div id="el133_ct" class="pw-tooltip" data-id="133"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el134_off" data-id="134" data-set="AminoAcidDbox" data-type="" class="mdsc_aminoaciddepletion pw-label2 pw-left pw-none el-off134" style="top:398px;left:319px;"> <div class="pw_txtBox" style="width:363px;text-align: left;"><h4 style="border-bottom: solid 1px #000;margin-bottom:8px;padding-bottom:0px;">Amino Acid Depletion and Production of Immunosuppressive Metabolites</h4> <strong>T Cells</strong><br> • Loss of TCR-CD3 zeta chain <br> • Inhibits proliferation and activity<br> <strong>Tregs</strong><br> • Promotes development<br> <strong>Natural Killer Cells</strong><br> • Inhibits proliferation and activity </div> </div> <div id="el134_ct" class="pw-tooltip" data-id="134"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el135_off" data-id="135" data-set="ROSandRNSbox" data-type="" class="mdsc_rosandrns pw-label2 pw-left pw-none el-off135" style="top:467px;left:303px;"> <div class="pw_txtBox" style="width:363px;text-align: left;"><h4 style="border-bottom: solid 1px #000;margin-bottom:8px;padding-bottom:0px;">Generation of Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS)</h4> <strong>T Cells</strong><br> <strong>NO</strong><br> • Inhibits IL-2 signaling<br> • Inhibits proliferation and migration<br> <strong>Peroxynitrite</strong><br> • Promotes nitration or nitrosylation of TCR, CD3, CD8, CCL2, and others<br> • Inhibits activation<br> • Inhibits intra-tumoral migration<br> • Induces apoptosis<br> <strong>H<sub>2</sub>O<sub>2</sub></strong><br> • Loss of TCR-CD3 zeta chain <br> • Promotes proliferative arrest<br> • Induces apoptosis </div> </div> <div id="el135_ct" class="pw-tooltip" data-id="135"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el136_off" data-id="136" data-set="Inhibitorbox" data-type="" class="mdsc_tcellinhibitoryapoptoticreceptors pw-label2 pw-left pw-none el-off136" style="top:506px;left:139px;"> <div class="pw_txtBox" style="width:363px;text-align: left;"><h4 style="border-bottom: solid 1px #000;margin-bottom:8px;padding-bottom:0px;">Direct Engagement of T Cell Inhibitory and Apoptotic Receptors </h4> <strong>Effector T Cells</strong><br> <strong>Galectin-9-TIM-3</strong><br> • Inhibits Th1 responses<br> • Induces CD8<sup>+</sup> and CD4<sup>+</sup> T cell apoptosis<br> <strong>Fas L-Fas</strong><br> • Induces CD8<sup>+</sup> and CD4<sup>+</sup> T cell apoptosis<br> <strong>PD-L1-PD-1</strong><br> • Inhibits T cell activation<br> • Induces T cell cycle arrest, anergy, and apoptosis </div> </div> <div id="el136_ct" class="pw-tooltip" data-id="136"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el137_off" data-id="137" data-set="ProdInhibitoryBox" data-type="" class="mdsc_prodinhibitorycytokines pw-label2 pw-left pw-none el-off137" style="top:205px;left:344px;"> <div class="pw_txtBox" style="width:363px;text-align: left;"><h4 style="border-bottom: solid 1px #000;margin-bottom:8px;padding-bottom:0px;">Production of Inhibitory Cytokines</h4> <strong>Tregs</strong><br> • Promotes expansion<br> <strong>Dendritic Cells</strong><br> • Inhibits IL-12 secretion and maturation<br> • Inhibits co-stimulatory molecule expression<br> • Promotes the production of immunosuppressive molecules<br> <strong>Effector T Cells</strong><br> • Inhibits activation and differentiation<br> • Inhibits cytokine production<br> <strong>Natural Killer Cells, CD8<sup>+</sup> T Cells</strong><br> • Down-regulates NKG2D and NKp30<br> • Inhibits NK cell proliferation and cytotoxicity<br> <strong>M2 Macrophages</strong><br> • Promotes monocyte/macrophage recruitment<br> • Promotes M2 polarization </div> </div> <div id="el137_ct" class="pw-tooltip" data-id="137"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el138_off" data-id="138" data-set="InhibitionTCellBox" data-type="" class="mdsc_inhibitiontcellhoming pw-label2 pw-left pw-none el-off138" style="top:636px;left:209px;"> <div class="pw_txtBox" style="width:363px;text-align: left;"><h4 style="border-bottom: solid 1px #000;margin-bottom:8px;padding-bottom:0px;">Inhibition of T Cell Homing to the Lymph Nodes</h4> <strong>Naive CD4<sup>+</sup> and CD8<sup>+</sup> T Cells</strong><br> • Down-regulates L-Selectin/CD62L<br> • Inhibits naive T cell trafficking and activation </div> </div> <div id="el138_ct" class="pw-tooltip" data-id="138"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el139_off" data-id="139" data-set="ProdAdenosineBox" data-type="" class="mdsc_prodadenosine pw-label2 pw-left pw-none el-off139" style="top:255px;left:346px;"> <div class="pw_txtBox" style="width:363px;text-align: left;"><h4 style="border-bottom: solid 1px #000;margin-bottom:8px;padding-bottom:0px;">Production of Extracellular Adenosine</h4> <strong>Dendritic Cells</strong><br> • Inhibits IL-12 secretion and maturation<br> • Promotes the production of immunosuppressive molecules<br> <strong>Effector T Cells </strong><br> • Inhibits activity<br> <strong>Natural Killer Cells</strong><br> • Inhibits activity<br> <strong>NKT Cells</strong><br> • Inhibits activity<br> <strong>M2 Macrophages</strong><br> • Promotes activation<br> <strong>Tregs</strong><br> • Promotes differentiation<br> • Enhances suppression </div> </div> <div id="el139_ct" class="pw-tooltip" data-id="139"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el140_off" data-id="140" data-set="S100A8Box" data-type="" class="mdsc_s100a8_s100a9-mediatedaccumulation pw-label2 pw-left pw-none el-off140" style="top:218px;left:356px;"> <div class="pw_txtBox" style="width:363px;text-align: left;"><h4 style="border-bottom: solid 1px #000;margin-bottom:8px;padding-bottom:0px;">S100A8/A9-Mediated Accumulation of MDSCs</h4> <strong>MDSCs</strong><br> • Inhibits myeloid precursor cell differentiation <br> • Attracts MDSCs to the tumor microenvironment </div> </div> <div id="el140_ct" class="pw-tooltip" data-id="140"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> </div> <div id="pw-img"> <img id="cont-img" src="https://resources.rndsystems.com/images/Pathways/pathway-images/mdsc-bg_all_static_v2.png?t=1" alt="MDSC-Mediated Mechanisms of Immunosuppression" style="height:784px"> </div> </div> <div id="pathway-description"><p><div class="row"> <div class="col-md-4 col-xs-12"> <div class="featured-box"> <h2>Featured Literature</h2> <p><img src="//resources.rndsystems.com/images/site/a-look-inside-tumor-poster-400x200.jpg" alt="Featured Literature: A Look Inside a Tumor Poster" width="100%"></p> <h3>A Look Inside a Tumor Poster</h3> <p><a href="/resources/posters/look-inside-tumor-mechanism-tumor-evasion-and-immunosuppression-tumor" class="btn btn-senary" target="_blank">View Poster</a></p> </div> </div> <div class="col-md-4 col-xs-12"> <div class="featured-box"> <h2>Featured Blog Post</h2> <p><img src="//resources.rndsystems.com/images/site/targeting-myeloid-blog-400x200.jpg" alt="Targeting MDSCs for Cancer Immunotherapy" width="100%"></p> <h3>Targeting MDSCs for Cancer Immunotherapy</h3> <p><a href="/blog/immunology-news-targeting-myeloid-derived-suppressor-cells-mdscs-cancer-immunotherapy" class="btn btn-senary" target="_blank">View Blog</a></p> </div> </div> <div class="col-md-4 col-xs-12"> <div class="featured-box"> <h2>Featured Products</h2> <p><img src="//resources.rndsystems.com/images/site/mdsc-brochure-400x200.jpg" alt="Myeloid-derived Suppressor Cells Brochure" width="100%"></p> <h3>Myeloid-derived Suppressor Cells Brochure </h3> <p><a href="/resources/literature/myeloid-derived-suppressor-cells" class="btn btn-senary" target="_blank">View Brochure</a></p> </div> </div> <div style="clear:both"> </div> </div> <h2>Myeloid-derived Suppressor Cell (MDSC)-Mediated Mechanisms of Immunosuppression</h2> <style type="text/css"> .container_16 {padding:0px !important;} .main.grid_16, .grid_16.base_rnd_css {width:1170px !important;} #pw-nav-con { width: 750px; height: inherit !important; background: none; } #pw-nav-con H2 { margin: 7px 0 5px 16px; padding: 5px 0; font-size: 19px; font-weight: inherit; width: 730px; border: none; } #pw-nav-con ul { margin: 0; padding: 0; height: 40px; } .pw-blu-btn { width: inherit; float: left; margin-left: 15px;} #pw-nav-con .pw-blu-btn a { background: #005F9E; border-top: 1px solid #005f9f;} #pw-nav-con .pw-blu-btn-active { border-top: none;} #pw-nav-con .pw-drk-blu-btn, #pw-nav-con li a /*request print button*/ { display: initial; padding: 5px 10px; font-weight: bold; background: #ffffff; border: 1px solid #005f9f; color: #090909; border-radius: 4px;} #pw-nav-con .pw-blu-btn-active { margin-left: 15px; float: left;} #pw-map {float: left;} .related-information { background: #efefef; border: 1px solid #cccccc; position: relative; top: -54px;} .featured-links { display: block; text-decoration: none;} element.style { height: 300px; </style> <p>Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of early myeloid cells that accumulate during chronic inflammation, autoimmunity, infection, and cancer. Under healthy conditions, these precursor cells terminally differentiate into mature dendritic cells, granulocytes, and macrophages, but under pathological conditions, their differentiation is partially blocked, leading to an accumulation of the immature cells. Immature myeloid cell accumulation is of significant interest as these cells (now known as MDSCs) have immunosuppressive properties and are thought to play a key role in inhibition of the anti-tumor immune response. As a result, they are considered to be a major obstacle for cancer immunotherapy.</p> <h2>Amino Acid Depletion and Production of Immunosuppressive Metabolites by MDSCs</h2> <p>MDSCs inhibit the anti-tumor immune response through multiple mechanisms. One mechanism is through the depletion of amino acids and the production of immunosuppressive metabolites. MDSCs produce high levels of intracellular arginase 1 (ARG1), which leads to increased uptake of L-arginine and depletion of this amino acid from the environment. In the presence of low levels of L-arginine, T cells display reduced expression of TCR-CD3 zeta chain and undergo proliferative arrest. Additionally, MDSCs sequester cystine, which limits its availability to be taken up by antigen-presenting cells (APCs) and subsequently reduced and exported as cysteine. Unlike APCs, MDSCs are capable of importing cystine but they fail to export cysteine due to a lack of the ASC transporter. A reduction in cysteine levels is problematic for T cells, which are unable to generate their own cysteine due to the absence of cystathionine gamma-lyase, an enzyme required for the breakdown of cystathionine into cysteine, and the lack of a functional xc- cystine transporter. As a result, T cells rely on other cells to provide cysteine for their survival. Since cysteine is most highly required during T cell activation and subsequent proliferation and differentiation, it is typically provided to T cells by APCs during antigen presentation. In the presence of MDSCs, however, the levels of cystine imported and cysteine produced by APCs is reduced, thereby compromising T cell activation. MDSCs can also inhibit immune cell functions through the degradation of L-tryptophan. MDSCs express indolamine-2,3-dioxygenase (IDO), which catalyzes the initial, rate-limiting step in L-tryptophan degradation by the kynurenine pathway. The degradation of L-tryptophan and the presence of kynurenine and its derivatives inhibit the proliferation and activity of CD4<sup>+</sup> and CD8<sup>+</sup> T cells and natural killer cells and promote the differentiation of regulatory T cells (Tregs).</p> <h2>Generation of Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) by MDSCs</h2> <p>A second mechanism by which MDSCs inhibit the anti-tumor immune response is by the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Hydrogen peroxide, peryoxynitrite, and nitric oxide (NO) are produced by MDSCs through the activities of NADPH oxidase, arginase-1, and iNOS. These molecules have a variety of immunosuppressive effects on T cells. Hydrogen peroxide promotes loss of TCR-CD3 zeta chain expression and promotes T cell proliferative arrest and apoptosis. Nitric oxide inhibits IL-2 signaling and T cell proliferation and migration, and peryoxynitrite promotes T cell apoptosis, along with nitration or nitrosylation of multiple target molecules including TCR, CD3, CD8, and CCL2, which inhibits T cell activation and intra-tumoral migration. </p> <h2>Direct Engagement of T cell Inhibitory and Apoptotic Receptors by MDSCs</h2> <p>MDSCs may also suppress T cell functions through the direct engagement of T cell inhibitory and apoptotic receptors. In some tumors, activated MDSCs express high levels of PD-L1, Fas Ligand (Fas L), and Galectin-9. Interactions of these ligands with their respective T cell expressed receptors, PD-1, Fas/CD95, or Tim-3 has been shown to lead to either T cell exhaustion in the case of PD-L1/PD-1 or T cell apoptosis in the case of Fas L/Fas and Galectin-9/Tim-3.</p> <h2>Production of Inhibitory Cytokines by MDSCs</h2> <p>MDSCs also mediate immunosuppression through the production of IL-10 and TGF-beta 1. Together these cytokines inhibit the activation, differentiation, and proliferation of effector T cells, as well as inhibit cytokine production by these cells. Additionally, IL-10 and TGF-beta 1 promote the expansion of suppressive T cells. TGF-beta 1 induces the expression of FoxP3 in CD4<sup>+</sup>CD25<sup>-</sup> conventional T cells to promote a suppressor cell phenotype in these cells, while IL-10 promotes the conversion of activated conventional T cells to IL-10-, TGF-beta 1-secreting Tr1 cells. In addition to its effects on T cells, TGF-beta 1 also down-regulates the expression of NKG2D and NKp30 on natural killer (NK) cells and CD8<sup>+</sup> T cells, reduces NK cell proliferation and cytotoxicity, promotes the polarization of macrophages toward a M2 phenotype, and inhibits dendritic cell (DC) maturation and migration, co-stimulatory molecule expression and IL-12 production. </p> <h2>MDSC-Mediated Inhibition of T Cell Homing to the Lymph Nodes </h2> <p>MDSCs can also inhibit T cell activation by preventing the homing of naïve T cells to the lymph nodes. MDSCs were found to constitutively express Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), also known as TACE, which is a protease that has been shown to cleave L-Selectin/CD62L, among other targets. L-Selectin/CD62L plays a key role in directing antigen-naïve CD4<sup>+</sup> and CD8<sup>+</sup> T cells from the blood and lymphatics to the lymph nodes, where they can then become activated. In the presence of MDSCs, L-Selectin/CD62L on naïve T cells is cleaved by ADAM17, thereby preventing their homing and activation.</p> <h2>Production of Extracellular Adenosine by MDSCs</h2> <p>Similar to regulatory T cells (Tregs) and tumor cells themselves, MDSCs have also been shown to express the surface ectonucleotidases, CD39 and CD73, which work in concert to generate extracellular adenosine from ATP. Extracellular adenosine is an immunosuppressive metabolite that signals through the A2a and A2b receptors expressed on different immune cell types to regulate the activities of these cells and drive tumor escape. Adenosine has been shown to inhibit the proliferation and functions of effector T cells, natural killer (NK) cells, and natural killer T (NKT) cells, as well as indirectly affecting T cell functions by acting on antigen-presenting cells. Activation of A2a/A2b receptors on dendritic cells (DCs) promotes their production of immunosuppressive molecules and inhibits their production of IL-12 and TNF-alpha, as well as DC maturation. In addition, adenosine stimulates regulatory T cell (Treg) expansion and increases the suppressive activity of these cells.</p> <h2>Production of PGE<sub>2</sub> by MDSCs</h2> <p>MDSCs also produce prostaglandin E2 (PGE<sub>2</sub>) through the up-regulated expression of the PGE<sub>2</sub>-producing enzymes, COX2 and PGES1. In an autocrine feedback loop, MDSC-produced PGE<sub>2</sub> signals through its receptors expressed on the surface of MDSCs, to up-regulate their expression of arginase 1 (ARG1) and increase their suppressive activity. Additionally, PGE<sub>2</sub> has been shown to induce MDSC differentiation of bone marrow stem cells, thereby promoting MDSC expansion. Besides its effects on MDSCs themselves, PGE<sub>2</sub> has also been shown to inhibit the cytolytic activity of natural killer (NK) cells and the ability of these cells to produce IFN-gamma. It also inhibits the early stages of dendritic cell differentiation, suppresses IL-2 production and responsiveness in T cells, and inhibits NK/Th1/CD8<sup>+</sup> T cell-mediated immune responses while promoting Th2/Th17/Treg responses.</p> <h2>S100A8/A9-Mediated Accumulation of MDSCs</h2> <p>MDSCs promote their own accumulation through an S100A8/A9 autocrine feedback loop. MDSCs synthesize and secrete the calcium-binding proteins, S100A8 and S100A9 that bind to carboxylated N-glycans on the receptor for advanced glycation end-products (RAGE) and other glycoproteins receptors expressed on MDSCs. Interactions of S100A8/A9 with these receptors promotes MDSC accumulation and migration. As a result, S100A8/A9 plays a key role in both the generation and recruitment of MDSCs to the tumor microenvironment.</p> <p>To learn more, explore the following MDSC-related resources:</p> <p><a href="https://www.bio-techne.com/content/current-and-emerging-immune-checkpoint-targets-immuno-oncology-research-ebook" target="_blank">Current and Emerging Immune Checkpoint Targets for Immuno-Oncology Research eBook</a><br /> <a href="/research-area/myeloid--derived-suppressor-cells--mdsc">Myeloid-Derived Suppressor Cells (MDSC) research area page</a> <br> <a href="/resources/cell-markers/immune-cells/myeloid--derived-suppressor-cells">Cell Markers for Myeloid-Derived Suppressor Cell Subsets</a> <br> <a href="/blog/immunology-news-targeting-myeloid-derived-suppressor-cells-mdscs-cancer-immunotherapy">Blog Post – Immunology News: Targeting Myeloid-Derived Suppressor Cells (MDSCs) for Cancer Immunotherapy</a> <br> <a 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