Synthesis of Silver (I) Coordination of Aspirinate Azo Ligands as Potential Antibacterial Agents

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New antimicrobial drugs are in dire need and pivotal to overcome this issue. In this study, aspirinate azo ligands bearing different halogens L1-5 has been prepared via diazo-coupling reaction. The ligands L1-5 were coordinated with silver, Ag (I) metal to produce Ag (I) aspirin-azo complexes C1-5. The antibacterial properties of L1-5 and C1-5 were evaluated against Staphylococcus aureus and Escherichia coli using turbidimetric kinetic method. The complexes C1-5 showed comparable growth inhibition activity towards E. coli (MIC 82-105 ppm) and S. aureus (MIC 80-105 ppm) compared to ligands L1-5 with E. coli (MIC 83-200 ppm), S. aureus (80-131 ppm) and ampicillin (MIC 93 and 124 ppm, respectively). The excellent bacterial resistance of both L1-5 and C1-5 indicates the potential of aspirinate azo and their complexes as new antibacterial agents, which significantly benefit to the pharmaceutical industries." /> <meta name="keywords" content="Antimicrobial, Aspirin, Azo, Silver (I), Turbidimetric" /> <meta name="copyright" content="2021 Trans Tech Publications Ltd. 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Removal from Water <br /> <span class="paper-volume-number">p.93</span> </div> <div class="element-list-arrow"> <i class="inline-icon arrow-right-black no-focus-icon on-hover-arrow-left-red"></i> </div> </div> </a> </div> </div> <div class="right-content col-md-8 col-sm-7 col-xs-12 paper-title-main-page"> <div class="bread-crumbs hidden-xs"> <a class="bread-crumbs-first" href="/">Home</a><i class="inline-icon arrow-breadcrumbs"></i><a class="bread-crumbs-first" href="/DDF">Defect and Diffusion Forum</a><i class="inline-icon arrow-breadcrumbs"></i><a class="bread-crumbs-first" href="/DDF.411">Defect and Diffusion Forum Vol. 411</a><i class="inline-icon arrow-breadcrumbs"></i><span class="bread-crumbs-second">Synthesis of Silver (I) Coordination of Aspirinate...</span></div> <div class="page-name-block underline-begin"> <h1 class="page-name-block-text">Synthesis of Silver (I) Coordination of Aspirinate Azo Ligands as Potential Antibacterial Agents</h1> </div> <div class="paper-statistics"> <div class="loading"> <i class="inline-icon download-and-visitor-statistics-icon"></i> <span class="normal-text" id="paperDownloadsAndVisitorsCount"></span> </div> </div> <div class="clearfix"></div> <div class="page-paper-title"> <div class="preview-block"> <img alt="Article Preview" width="128" height="180" src="/DDF.411.17/thumbnail.gif"> <div id="preview-button" data-url-preview-log="/Paper/PreviewImageLog?paperId=578510"> <i class="inline-icon preview-icon"></i> </div>  <div id="paper-preview-modal" class="modal fade"> <div class="modal-dialog" role="document"> <div class="popup-page-name underline-begin"> <div class="page-name-block-text">Article Preview</div> </div> <img alt="Article Preview" class="preview-image lazyload" data-src="/DDF.411.17/preview.gif"> <a data-dismiss="modal" title="Close" class="inline-icon close-icon"></a> </div> </div>  </div> <div class="abstract-block-description"> <h3 class="page-paper-first-header">Abstract:</h3> <p class="normal-text"> The rise of antimicrobial resistance for infectious bacteria has become an alarming issue to human health. New antimicrobial drugs are in dire need and pivotal to overcome this issue. In this study, aspirinate azo ligands bearing different halogens L1-5 has been prepared <i>via</i> diazo-coupling reaction. The ligands L1-5 were coordinated with silver, Ag (I) metal to produce Ag (I) aspirin-azo complexes C1-5. The antibacterial properties of L1-5 and C1-5 were evaluated against <i>Staphylococcus aureus</i> and <i>E</i><i>scherichia</i><i> coli </i>using turbidimetric kinetic method. The complexes C1-5 showed comparable growth inhibition activity towards <i>E.</i><i> coli</i> (MIC 82-105 ppm) and <i>S</i><i>. </i><i>aureus</i> (MIC 80-105 ppm) compared to ligands L1-5 with <i>E. coli</i> (MIC 83-200 ppm), <i>S</i><i>.</i><i> aureus</i> (80-131 ppm) and ampicillin (MIC 93 and 124 ppm, respectively). The excellent bacterial resistance of both L1-5 and C1-5 indicates the potential of aspirinate azo and their complexes as new antibacterial agents, which significantly benefit to the pharmaceutical industries. </p> </div> <div class="paper-access-buttons col-xs-12"> <div class="row"> <div class="sa-button-wrap"> <a id="sa-button" class="wayfinder-login d-flex sa-button" href="javascript:;"> <div class="sa-button-logo-wrap"> <i class="inline-icon sa-white"></i> </div> <div class="d-flex justify-content-center align-items-center sa-button-text text-truncate"> <div class="sa-button-text-primary text-truncate">Access through your institution</div> </div> </a> </div> <div class="title-button-pdf"> <button id="readPaperButton" data-url-read-paper-log="/Paper/ReadThePaperLog?paperId=578510" class="button button-160"> <span class="inline-element">Read The Paper</span> </button> </div> </div> <div class="row"> </div> </div> <div class="clearfix"></div> <div class="connected-title-container"> 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data-url="/Paper/_Message?paperId=578510&personId=1546581&urlSent=https%3A%2F%2Fwww.scientific.net%2FDDF.411.17" title="Send message to Corresponding Author"> </a> <a href="/author-papers/z-ngaini">Zainab Ngaini</a>*, <a href="/author-papers/maya-asyikin-mohamad-arif">Maya Asyikin Mohamad Arif</a> </div> </div> </div> </div> <div class="papers-block-info col-lg-12"> <div class="row"> <div class="info-row-name normal-text-gray col-md-2 col-sm-3 col-xs-4"> <div class="row"> <p>Keywords:</p> </div> </div> <div class="info-row-content semibold-middle-text col-md-10 col-sm-9 col-xs-8"> <div class="row"> <a href="/paper-keyword/antimicrobial">Antimicrobial</a>, <a href="/paper-keyword/aspirin">Aspirin</a>, <a href="/paper-keyword/azo-1">Azo</a>, <a href="/paper-keyword/silver-i">Silver (I)</a>, <a href="/paper-keyword/turbidimetric">Turbidimetric</a> </div> </div> </div> </div> <div class="papers-block-info col-lg-12"> <div class="row"> <div class="info-row-name normal-text-gray col-md-2 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