Inxight Drugs

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NCATS Inxight incorporates and unifies a wealth of data, including marketing and regulatory status, rigorous drug ingredient definitions, biological activity, clinical use and more." /> <meta name="twitter:description" value="The National Center for Advancing Translational Sciences has developed Inxight Drugs — a comprehensive portal for drug development information.NCATS Inxight incorporates and unifies a wealth of data, including marketing and regulatory status, rigorous drug ingredient definitions, biological activity, clinical use and more." /> <meta property="og:image" content='https://drugs.ncats.io/assets/ginas/images/inxight_main.jpg?w=500' /> <meta name="twitter:image" content='https://drugs.ncats.io/assets/ginas/images/inxight_main.jpg?w=500' /> <meta name="twitter:label1" value="US Approved Drugs" /> <meta name="twitter:data1" value="2447" /> <meta name="twitter:label2" value="Total Substances" /> <meta name="twitter:data2" value="156829" />   <title>Inxight Drugs</title> 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ng-click ='forceFilters = !forceFilters'> <i class="fa fa-filter"></i> Show Filters </div> <div class="btn btn-primary hidden-md hidden-lg filtertoggle" id="hide-filters" ng-show="forceFilters" ng-click ='forceFilters = !forceFilters'> <i class="fa fa-filter"></i> Hide Filters </div> <div ng-class="(forceFilters)?'':'hidden-sm hidden-xs'" class="panel-group"> <div class="panel-group"> <div ng-cloak class="fade-ng-cloak ng-cloak" ng-controller="FiltersController"> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Development+Status&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Development Status","values":[{"label":"Other","count":107652},{"label":"Possibly Marketed Outside US","count":10255},{"label":"Clinical","count":9777},{"label":"US Approved Rx","count":1612},{"label":"US Previously Marketed","count":1444},{"label":"US Approved Allergenic Extract","count":680},{"label":"Designated","count":365},{"label":"US Approved 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<label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Primary+Target&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Primary Target","values":[{"label":"Dopamine D2 receptor","count":78},{"label":"Histamine H1 receptor","count":70},{"label":"Cyclooxygenase-2","count":60},{"label":"DNA","count":57},{"label":"GABA-A receptor; anion channel","count":49},{"label":"Beta-2 adrenergic receptor","count":46},{"label":"Beta-1 adrenergic receptor","count":44},{"label":"Bacterial penicillin-binding protein","count":42},{"label":"Acetylcholinesterase","count":40},{"label":"Bacterial 70S ribosome","count":40},{"label":"Serotonin 2a (5-HT2a) receptor","count":40},{"label":"Cyclooxygenase-1","count":39},{"label":"Glucocorticoid receptor","count":39},{"label":"Mu opioid receptor","count":38},{"label":"Voltage-gated L-type calcium channel","count":38},{"label":"Muscarinic acetylcholine receptor","count":36},{"label":"Oxidative Stress","count":36},{"label":"Adrenergic receptor alpha-1","count":35},{"label":"Androgen Receptor","count":35},{"label":"Muscarinic acetylcholine receptor M3","count":34}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Primary+Target&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=false;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Highest+Phase&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Highest Phase","values":[{"label":"Approved","count":2673},{"label":"Phase III","count":133},{"label":"Phase II","count":96},{"label":"Not Provided","count":68},{"label":"Phase IV","count":32},{"label":"Phase I","count":23}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Highest+Phase&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=false;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Approval+Year&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Approval Year","values":[{"label":"Unknown","count":2708},{"label":"2020","count":644},{"label":"2012","count":515},{"label":"2013","count":510},{"label":"2011","count":487},{"label":"2016","count":434},{"label":"2014","count":430},{"label":"2021","count":401},{"label":"2023","count":398},{"label":"2015","count":384},{"label":"2010","count":382},{"label":"2018","count":381},{"label":"2017","count":356},{"label":"2022","count":321},{"label":"2019","count":274},{"label":"2009","count":272},{"label":"1972","count":154},{"label":"2007","count":150},{"label":"2004","count":145},{"label":"2003","count":127}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Approval+Year&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Condition&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Condition","values":[{"label":"Unknown","count":229},{"label":"Hypertension","count":143},{"label":"Pain","count":121},{"label":"Breast cancer","count":76},{"label":"Rheumatoid arthritis","count":74},{"label":"Schizophrenia","count":67},{"label":"Type 2 diabetes mellitus","count":64},{"label":"Cancer","count":60},{"label":"Alzheimer’s disease","count":59},{"label":"Asthma","count":58},{"label":"Osteoarthritis","count":54},{"label":"Anxiety","count":50},{"label":"Urinary tract infections","count":49},{"label":"Bacterial infections","count":47},{"label":"Sunburn","count":47},{"label":"Parkinson's disease","count":42},{"label":"Depression","count":40},{"label":"HIV-1 infection","count":37},{"label":"Major depressive disorder","count":37},{"label":"Acne","count":35}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Condition&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Treatment+Modality&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Treatment Modality","values":[{"label":"Primary","count":2124},{"label":"Curative","count":549},{"label":"Palliative","count":428},{"label":"Preventing","count":321},{"label":"Diagnostic","count":164},{"label":"Inactive ingredient","count":149},{"label":"Secondary","count":95},{"label":"Preventive","count":2},{"label":"Inactive Ingredient","count":1}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Treatment+Modality&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=CNS+Activity&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"CNS Activity","values":[{"label":"CNS Active","count":832},{"label":"CNS Penetrant","count":576},{"label":"CNS Non-penetrant","count":287}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=CNS+Activity&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Originator&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Originator","values":[{"label":"Pfizer","count":69},{"label":"Merck","count":54},{"label":"Boehringer Ingelheim","count":40},{"label":"Bayer","count":35},{"label":"Hoffman-La Roche","count":35},{"label":"Eli Lilly","count":32},{"label":"Novartis","count":31},{"label":"Bristol-Myers Squibb","count":30},{"label":"GlaxoSmithKline","count":22},{"label":"AstraZeneca","count":21},{"label":"Ciba-Geigy","count":21},{"label":"Wyeth","count":21},{"label":"Takeda Pharmaceutical","count":20},{"label":"Roche","count":19},{"label":"Sanofi-Aventis","count":18},{"label":"Syntex","count":17},{"label":"Cession-Fossion, A.|Monard, Y.|Dresse, A.","count":15},{"label":"Imperial Chemical Industries","count":15},{"label":"Parke Davis","count":15},{"label":"Yamanouchi Pharmaceutical","count":15}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Originator&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Substance+Class&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Substance Class","values":[{"label":"chemical","count":6320},{"label":"structurallyDiverse","count":4001},{"label":"polymer","count":950},{"label":"mixture","count":734},{"label":"protein","count":518},{"label":"concept","count":104},{"label":"specifiedSubstanceG1","count":50},{"label":"nucleicAcid","count":25}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Substance+Class&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=INN+Stem&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"INN Stem","values":[{"label":"Chemical substance(-ine)","count":66},{"label":"Monoclonal antibodies(-mab)","count":6},{"label":"Gene Therapy vectors(-vec)","count":3},{"label":"Peptides and glycopeptides(-tide)","count":3},{"label":"Beta-blockers(-olol)","count":1},{"label":"Tyrosine-kinase inhibitors(-tinib)","count":1}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=INN+Stem&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=GInAS+Tag&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"GInAS Tag","values":[{"label":"KEW","count":614}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=GInAS+Tag&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Code+System&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Code System","values":[{"label":"FDA UNII","count":12702},{"label":"DAILYMED","count":9372},{"label":"RXCUI","count":8474},{"label":"CAS","count":8431},{"label":"EPA CompTox","count":6463},{"label":"PUBCHEM","count":6390},{"label":"EVMPD","count":5760},{"label":"NCI_THESAURUS","count":5314},{"label":"WIKIPEDIA","count":4771},{"label":"SMS_ID","count":4622},{"label":"DRUG BANK","count":4501},{"label":"MERCK INDEX","count":4001},{"label":"ECHA (EC/EINECS)","count":3649},{"label":"ChEMBL","count":3572},{"label":"MESH","count":3393},{"label":"INN","count":3339},{"label":"DRUG CENTRAL","count":2714},{"label":"CHEBI","count":2567},{"label":"WHO-ATC","count":2336},{"label":"WHO-VATC","count":2044}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Code+System&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Protein+Type&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Protein Type","values":[{"label":"MONOCLONAL ANTIBODY","count":131},{"label":"PEPTIDE","count":22},{"label":"ENZYME","count":19},{"label":"HORMONE","count":16},{"label":"CYTOKINE","count":13},{"label":"STRUCTURAL PROTEIN","count":11},{"label":"MONOCLONAL ANTIBODY CONJUGATE","count":10},{"label":"BISPECIFIC ANTIBODY","count":9},{"label":"GROWTH FACTOR","count":9},{"label":"COAGULATION FACTOR","count":5},{"label":"FUSION PROTEIN","count":4},{"label":"ENZYME INHIBITOR","count":2},{"label":"FAB","count":2},{"label":"ALLERGEN","count":1},{"label":"CARRIER PROTEIN","count":1},{"label":"FUSION PROTEINS","count":1},{"label":"RECEPTOR","count":1},{"label":"TOXIN","count":1},{"label":"TRANSFERRIN FAMILY","count":1},{"label":"VACCINE ANTIGEN","count":1}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Protein+Type&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=ATC+Level+1&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"ATC Level 1","values":[{"label":"NERVOUS SYSTEM","count":374},{"label":"ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS","count":301},{"label":"CARDIOVASCULAR SYSTEM","count":288},{"label":"ALIMENTARY TRACT AND METABOLISM","count":286},{"label":"ANTIINFECTIVES FOR SYSTEMIC USE","count":263},{"label":"DERMATOLOGICALS","count":196},{"label":"RESPIRATORY SYSTEM","count":181},{"label":"GENITO URINARY SYSTEM AND SEX HORMONES","count":150},{"label":"MUSCULO-SKELETAL SYSTEM","count":138},{"label":"SENSORY ORGANS","count":134},{"label":"VARIOUS","count":121},{"label":"BLOOD AND BLOOD FORMING ORGANS","count":117},{"label":"ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS","count":78},{"label":"SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS","count":56},{"label":"A ALIMENTARY TRACT AND METABOLISM","count":1},{"label":"ANTIHEMORRHAGICS","count":1},{"label":"COUGH AND COLD PREPARATIONS","count":1},{"label":"DIAGNOSTIC RADIOPHARMACEUTICALS","count":1}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=ATC+Level+1&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=ATC+Level+2&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"ATC Level 2","values":[{"label":"ANTINEOPLASTIC AGENTS","count":187},{"label":"ANTIBACTERIALS FOR SYSTEMIC USE","count":153},{"label":"OPHTHALMOLOGICALS","count":130},{"label":"PSYCHOLEPTICS","count":121},{"label":"CARDIAC THERAPY","count":91},{"label":"PSYCHOANALEPTICS","count":80},{"label":"ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS","count":68},{"label":"ANALGESICS","count":60},{"label":"SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM","count":58},{"label":"IMMUNOSUPPRESSANTS","count":57},{"label":"ANTIVIRALS FOR SYSTEMIC USE","count":56},{"label":"ANTITHROMBOTIC AGENTS","count":51},{"label":"DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS","count":48},{"label":"ANTIFUNGALS FOR DERMATOLOGICAL USE","count":46},{"label":"DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES","count":46},{"label":"DRUGS USED IN DIABETES","count":45},{"label":"ANTIPROTOZOALS","count":43},{"label":"ANTIHISTAMINES FOR SYSTEMIC USE","count":42},{"label":"COUGH AND COLD PREPARATIONS","count":42},{"label":"ALL OTHER THERAPEUTIC PRODUCTS","count":41}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=ATC+Level+2&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=ATC+Level+3&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"ATC Level 3","values":[{"label":"OTHER ANTINEOPLASTIC AGENTS","count":125},{"label":"ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS","count":63},{"label":"IMMUNOSUPPRESSANTS","count":57},{"label":"DIRECT ACTING ANTIVIRALS","count":56},{"label":"ANTIPSYCHOTICS","count":55},{"label":"ANTIDEPRESSANTS","count":51},{"label":"ANTITHROMBOTIC AGENTS","count":51},{"label":"ANTIFUNGALS FOR TOPICAL USE","count":46},{"label":"ANTIHISTAMINES FOR SYSTEMIC USE","count":42},{"label":"ANTIINFECTIVES","count":41},{"label":"ALL OTHER THERAPEUTIC PRODUCTS","count":40},{"label":"ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS","count":40},{"label":"OTHER BETA-LACTAM ANTIBACTERIALS","count":40},{"label":"HYPNOTICS AND SEDATIVES","count":39},{"label":"IMMUNOSTIMULANTS","count":37},{"label":"BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS","count":36},{"label":"DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE","count":34},{"label":"OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS","count":33},{"label":"CORTICOSTEROIDS, PLAIN","count":31},{"label":"ANTIEPILEPTICS","count":30}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=ATC+Level+3&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=ATC+Level+4&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"ATC Level 4","values":[{"label":"Protein kinase inhibitors","count":44},{"label":"Antibiotics","count":39},{"label":"Other antineoplastic agents","count":39},{"label":"Benzodiazepine derivatives","count":35},{"label":"Monoclonal antibodies","count":31},{"label":"Enzymes","count":27},{"label":"Selective immunosuppressants","count":25},{"label":"Antiinflammatory preparations, non-steroids for topical use","count":24},{"label":"Antidotes","count":23},{"label":"Other antifungals for topical use","count":21},{"label":"Platelet aggregation inhibitors excl. heparin","count":21},{"label":"Non-selective monoamine reuptake inhibitors","count":20},{"label":"Other antihistamines for systemic use","count":19},{"label":"Progestogens and estrogens, fixed combinations","count":19},{"label":"Corticosteroids, potent (group III)","count":18},{"label":"Imidazole and triazole derivatives","count":18},{"label":"Other antidepressants","count":18},{"label":"Other antivirals","count":18},{"label":"Other cough suppressants","count":18},{"label":"Adrenergic and dopaminergic agents","count":17}],"enhanced":true,"prefix":"","_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=ATC+Level+4&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> <div id="facet-wrapper" ng-controller="FilterController" class="panel panel-default" ng-init="init('https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Substance+Form&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited', {"name":"Substance Form","values":[{"label":"Principal Form","count":12702},{"label":"Salts, Hydrates, Esters, etc.","count":6102}],"enhanced":true,"prefix":"","selectedLabels":["Principal Form"],"_self":"https://drugs.ncats.io/api/v1/substances/search/@facets?wait=false&kind=ix.ginas.models.v1.Substance&skip=0&fdim=20&sideway=true&field=Substance+Form&top=156829&fskip=0&fetch=100&termfilter=SubstanceDeprecated%3Afalse&facet=Substance+Form%2FPrincipal+Form&facet=Development+Status%2FPossibly+Marketed+Outside+US&facet=Development+Status%2FUS+Approved+Rx&facet=Development+Status%2FUS+Approved+OTC&facet=Development+Status%2FUS+Approved+Allergenic+Extract&order=%5EsSubstance+Form&order=%5EsubstanceTypeSort&order=%5EsDevelopment+Status&order=%24Direct+Curated&order=%24sApproval+Year&order=%24lastEdited"});collapsed=true;"> <div class="panel-heading flexbox" id="facet-heading"> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <i ng-cloak ="" ng-show="collapsed" class="fa fa-caret-right"></i> <i ng-cloak ="" ng-hide="collapsed" class="fa fa-caret-down"></i> </h3> <h3 ng-cloak class="panel-title facet-title" ng-click="collapsed=!collapsed"> <span ng-bind="facetName"></span> </h3> <h3 class="panel-title facet-title"> <info-tooltip id="filter-info-popup" ng-if="facetInfoLabel" facetinfo="facetInfoLabel" class="flexbox"> </info-tooltip> </h3> </div> <div ng-cloak ng-show="showFacetSearch()"> <input type="text" id="facet-search" class="form-control" aria-label="Search filters" title="Search" placeholder="Search {{facetName}}..." ng-model="fq" ng-change="dofilter()" autocomplete="off" > </div> <div id="facet-body" class="panel-body" uib-collapse="collapsed"> <ul class="list-group"> <div ng-hide="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in ofacets | limitTo:quantity"> <div ng-if="facet.display"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input id="{{facet.mid}}" type="checkbox" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" id="filter-label"> <label for="{{facet.mid}}"> {{facet.display}} </label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> </div> <div ng-show="filtered"> <div ng-cloak class="list-group-item row" ng-repeat="facet in facets | limitTo:quantity"> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" id="filter-checkbox-wrapper"> <input type="checkbox" id="{{facet.mid}}" ng-click="fToggle(facet)" ng-model="facet.checked" /> </div> <div class="col-lg-9 col-md-8 col-sm-8 col-xs-5" > <label for="{{facet.mid}}" ng-bind-html="facet.labelHighlight"></label> </div> <div class="col-lg-1 col-md-1 col-sm-1 col-xs-1" > <span class="badge pull-right">{{facet.count}}</span> </div> </div> </div> <div style="float: left;" > <button ng-show="showShowMore()" ng-click="showMore()" type="button" uib-tooltip="Show More" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW MORE... </button> <button ng-show="showShowLess()" ng-click="showLess()" type="button" uib-tooltip="Show Less" tooltip-placement="right" class="btn btn-url font-monospace" id="facet-show-button"> SHOW LESS </button> </div> <div class="row" id="filter-bool-section"> <div ng-if="selectedFacets.length>0" id="filter-bool-separator"> </div> <form> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}allof" name="facettype" value="all"> <label class="subtle-label" id="filter-label" for="{{facetName}}allof">All Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange()" type="radio" ng-model="facetType" id="{{facetName}}anyof" name="facettype" value="any"> <label class="subtle-label" id="filter-label" for="{{facetName}}anyof">Any Match</label> </div> <div class="col-md-12" ng-show="selectedFacets.length>1"> <input ng-click="typeChange(true)" type="radio" ng-model="facetType" id="{{facetName}}notof1" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof1">Exclude Selected</label> </div> <div class="col-md-12" ng-show="selectedFacets.length==1"> <input ng-click="typeChange(isnegated)" type="checkbox" ng-model="isnegated" id="{{facetName}}notof2" name="facettype" value="not"> <label class="subtle-label" id="filter-label" for="{{facetName}}notof2">Exclude Selected</label> </div> </form> </div> <div class="col-lg-12 col-md-12 col-sm-10 col-xs-7 nopadding"> <div class="pull-right" id="filters-buttons-group"> <button ng-show="selectedFacets.length" ng-click="clear()" type="button" uib-tooltip="Clear Filters" class="btn btn-url"> Clear </button> <button ng-show="changed" ng-click="apply()" type="button" uib-tooltip="Apply Filters" class="btn btn-primary"> Apply </button> </div> </div> </ul> </div> </div> </div> </div> </div> </div> <div ng-class="(hideall)?'col-md-12':'col-md-9'"> <div class="alert alert-success alert-dismissible" role="alert" id="selected-filter-container"> <div id="selected-filter-container-inner"> <button style="margin-top:2px;" class="btn btn-primary toggle-force" data-toggle="popover" data-animation="false" data-placement="top" data-trigger="hover focus" data-html="true" data-content="<div>Click to remove filter:<br> <strong>Substance Form</strong> <i>MAY BE</i> <strong>Principal Form</strong> </div>" onclick="removeFacet('Substance Form','Principal Form')" > Substance Form   <span class="badge"> Principal Form </span> <span class="fa fa-remove" aria-hidden="true"></span> </button> <button style="margin-top:2px;" class="btn btn-primary toggle-force" data-toggle="popover" data-animation="false" data-placement="top" data-trigger="hover focus" data-html="true" data-content="<div>Click to remove filter:<br> <strong>Development Status</strong> <i>MAY BE</i> <strong>Possibly Marketed Outside US</strong> </div>" onclick="removeFacet('Development Status','Possibly Marketed Outside US')" > Development Status   <span class="badge"> Possibly Marketed Outside US </span> <span class="fa fa-remove" aria-hidden="true"></span> </button> <button style="margin-top:2px;" class="btn btn-primary toggle-force" data-toggle="popover" data-animation="false" data-placement="top" data-trigger="hover focus" data-html="true" data-content="<div>Click to remove filter:<br> <strong>Development Status</strong> <i>MAY BE</i> <strong>US Approved Rx</strong> </div>" onclick="removeFacet('Development Status','US Approved Rx')" > Development Status   <span class="badge"> US Approved Rx </span> <span class="fa fa-remove" aria-hidden="true"></span> </button> <button style="margin-top:2px;" class="btn btn-primary toggle-force" data-toggle="popover" data-animation="false" data-placement="top" data-trigger="hover focus" data-html="true" data-content="<div>Click to remove filter:<br> <strong>Development Status</strong> <i>MAY BE</i> <strong>US Approved OTC</strong> </div>" onclick="removeFacet('Development Status','US Approved OTC')" > Development Status   <span 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value="" selected>Sort By</option> </select> </div> </div> </div> </div> <div class="placeholder-content"> <div class= "panel-body record-container"> <div class = "row in" ng-show="!gridView" id ="list"> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/80VUN7L00C " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> ENMETAZOBACTAM </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a href=" /drug/80VUN7L00C " uib-tooltip="view record details" target="_self"> <span class="font-monospace">80VUN7L00C</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = "showLarge('6341bdaf-9724-43e0-90da-0fe88a4e728a', '24ba821f-1744-49e7-b440-2bc0b65aedf0')" > <rendered id = '6341bdaf-9724-43e0-90da-0fe88a4e728a' ctx='mubvehgqou'> </rendered> <div> </div> </div> </div> <div class = "row col-md-12 hidden-sm hidden-xs"> </div> </div> <div class = "col-lg-1 col-md-1 col-sm-1 col-xs-1 text-center"> <ul class= "table-cell list-unstyled tools"> <li list-style="none"> <modal-button type= "export" structureid ="'24ba821f-1744-49e7-b440-2bc0b65aedf0'" format="mol" format2="sdf" ></modal-button> </li> <li list-style="none"> <a ng-href="/structure?q=6341bdaf-9724-43e0-90da-0fe88a4e728a" target="_self" uib-tooltip="Structure Search" tooltip-placement="right" tooltip-append-to-body="true" aria-label="Structure Search"> <span class="sr-only"> Search for Structure </span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> <div class = "hidden-lg hidden-md col-sm-8 col-xs-8"> </div> <div class = "col-lg-8 col-md-7 col-sm-12 col-xs-12"> <div class = "row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2024) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA216165 </div> (2024) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216165">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216165</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2024 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA216165 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216165">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216165</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-absolute"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ABSOLUTE)</span> </div> </div> <hr id="additional-details-separator"> </div> </div> </div> </div> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/2OYE00PC25 " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> RITLECITINIB </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a>   <a href=" /drug/2OYE00PC25 " uib-tooltip="view record details" target="_self"> <span class="font-monospace">2OYE00PC25</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = "showLarge('5f671d47-1f16-4668-b15d-7aa529e0ef6b', 'ccdd2bf2-51d8-449b-ba85-d61cea709994')" > <rendered id = '5f671d47-1f16-4668-b15d-7aa529e0ef6b' ctx='mubvehgqou'> </rendered> <div> </div> </div> </div> <div class = "row col-md-12 hidden-sm hidden-xs"> </div> </div> <div class = "col-lg-1 col-md-1 col-sm-1 col-xs-1 text-center"> <ul class= "table-cell list-unstyled tools"> <li list-style="none"> <modal-button type= "export" structureid ="'ccdd2bf2-51d8-449b-ba85-d61cea709994'" format="mol" format2="sdf" ></modal-button> </li> <li list-style="none"> <a ng-href="/structure?q=5f671d47-1f16-4668-b15d-7aa529e0ef6b" target="_self" uib-tooltip="Structure Search" tooltip-placement="right" tooltip-append-to-body="true" aria-label="Structure Search"> <span class="sr-only"> Search for Structure </span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> <div class = "hidden-lg hidden-md col-sm-8 col-xs-8"> </div> <div class = "col-lg-8 col-md-7 col-sm-12 col-xs-12"> <div class = "row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2023) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA215830 </div> (2023) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=215830">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=215830</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2023 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA215830 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=215830">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=215830</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-absolute"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ABSOLUTE)</span> </div> </div> <hr id="additional-details-separator"> <div class = 'row'><div class = 'col-md-3 col-sm-3 col-xs-3'><span id='additional-details-title'>Targets:</span></div><div class = 'col-md-9 col-sm-9 col-xs-9'><div class='fval'><div class='facet-val'><a title='Tyrosine-protein kinase JAK3' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FTyrosine-protein kinase JAK3"><div class='facet-val-text'>Tyrosine-protein kinase JAK3</div><span class="badge badge-light">27</span></a></div></div><div class='fval'><div class='facet-val'><a title='Tyrosine-protein kinase JAK1' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FTyrosine-protein kinase JAK1"><div class='facet-val-text'>Tyrosine-protein kinase JAK1</div><span class="badge badge-light">38</span></a></div></div><div class='fval'><div class='facet-val'><a title='Tyrosine-protein kinase JAK2' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FTyrosine-protein kinase JAK2"><div class='facet-val-text'>Tyrosine-protein kinase JAK2</div><span class="badge badge-light">55</span></a></div></div><div class='fval'><div class='facet-val'><a title='Tyrosine-protein kinase TYK2' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FTyrosine-protein kinase TYK2"><div class='facet-val-text'>Tyrosine-protein kinase TYK2</div><span class="badge badge-light">16</span></a></div></div></div></div><hr id='additional-details-separator'> </div> </div> <div> <div class='text-block'>PF-06651600 is a newly discovered irreversible covalent JAK3-selective inhibitor. A high level of selectivity towards JAK3 is achieved by the covalent interaction of PF-06651600 with a unique cysteine residue (Cys-909) in the catalytic domain of JAK3, which is replaced by a serine residue in the other JAK isoforms. PF-06651600 allowed the comparison of JAK3-selective inhibition to pan-JAK or JAK1-selective inhibition, in relevant immune cells to a level that could not be achieved previously without such potency and selectivity. In vitro, PF-06651600 inhibits Th1 and Th17 cell differentiation and function, and in vivo it reduces disease pathology in rat adjuvant-induced arthritis as well as in mouse experimental autoimmune encephalomyelitis models. Preclinical data demonstrates that inhibition of the cytolytic function of CD8+ T cells and NK cells by PF-06651600 is driven by the inhibition of TEC kinases. Based on the underlying pathophysiology of inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, alopecia areata and vitiligo, the dual activity of PF06651600 towards JAK3 and the TEC kinase family may provide a beneficial inhibitory profile for therapeutic intervention. PF-06651600 is in phase III clinical trial for the treatment of alopecia areata and in phase II clinical trial for the treatment of Crohn's disease, Rheumatoid arthritis, Ulcerative colitis and Vitiligo.</div> </div> </div> </div> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/6O01GMS00P " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> MOMELOTINIB </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a>   <a href=" /drug/6O01GMS00P " uib-tooltip="view record details" target="_self"> <span class="font-monospace">6O01GMS00P</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = "showLarge('dd382f7f-e8a4-45c6-a7d5-9e236a823d20', '7894bea2-a180-493b-a693-bac5eeac493e')" > <rendered id = 'dd382f7f-e8a4-45c6-a7d5-9e236a823d20' ctx='mubvehgqou'> </rendered> <div> </div> </div> </div> <div class = "row col-md-12 hidden-sm hidden-xs"> </div> </div> <div class = "col-lg-1 col-md-1 col-sm-1 col-xs-1 text-center"> <ul class= "table-cell list-unstyled tools"> <li list-style="none"> <modal-button type= "export" structureid ="'7894bea2-a180-493b-a693-bac5eeac493e'" format="mol" format2="sdf" ></modal-button> </li> <li list-style="none"> <a ng-href="/structure?q=dd382f7f-e8a4-45c6-a7d5-9e236a823d20" target="_self" uib-tooltip="Structure Search" tooltip-placement="right" tooltip-append-to-body="true" aria-label="Structure Search"> <span class="sr-only"> Search for Structure </span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> <div class = "hidden-lg hidden-md col-sm-8 col-xs-8"> </div> <div class = "col-lg-8 col-md-7 col-sm-12 col-xs-12"> <div class = "row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2023) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA216873 </div> (2023) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216873">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216873</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2023 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA216873 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216873">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216873</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-achiral"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ACHIRAL)</span> </div> </div> <hr id="additional-details-separator"> <div class = 'row'><div class = 'col-md-3 col-sm-3 col-xs-3'><span id='additional-details-title'>Targets:</span></div><div class = 'col-md-9 col-sm-9 col-xs-9'><div class='fval'><div class='facet-val'><a title='Tyrosine-protein kinase JAK1' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FTyrosine-protein kinase JAK1"><div class='facet-val-text'>Tyrosine-protein kinase JAK1</div><span class="badge badge-light">38</span></a></div></div><div class='fval'><div class='facet-val'><a title='Tyrosine-protein kinase JAK2' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FTyrosine-protein kinase JAK2"><div class='facet-val-text'>Tyrosine-protein kinase JAK2</div><span class="badge badge-light">55</span></a></div></div></div></div><hr id='additional-details-separator'> <div class = 'row'><div class = 'col-md-3 col-sm-3 col-xs-3'><span id='additional-details-title'>Conditions:</span></div><div class = 'col-md-9 col-sm-9 col-xs-9'><div class='fval'><div class='facet-val'><a title='Pancreatic cancer' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FPancreatic cancer"><div class='facet-val-text'>Pancreatic cancer</div><span class="badge badge-light">97</span></a></div></div><div class='fval'><div class='facet-val'><a title='Non-small cell lung cancer' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FNon-small cell lung cancer"><div class='facet-val-text'>Non-small cell lung cancer</div><span class="badge badge-light">206</span></a></div></div><div class='fval'><div class='facet-val'><a title='Secondary myelofibrosis (post-polycythemia vera and post-essential thrombocythemia)' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FSecondary myelofibrosis (post-polycythemia vera and post-essential thrombocythemia)"><div class='facet-val-text'>Secondary myelofibrosis (post-polycythemia vera and post-essential thrombocythemia)</div><span class="badge badge-light">3</span></a></div></div><div class='fval'><div class='facet-val'><a title='Primary myelofibrosis' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FPrimary myelofibrosis"><div class='facet-val-text'>Primary myelofibrosis</div><span class="badge badge-light">7</span></a></div></div></div></div><hr id='additional-details-separator'> </div> </div> <div> <div class='text-block'>Momelotinib (CYT387) is an ATP-competitive small molecule that potently inhibits JAK1/JAK2 kinases. Momelotinib is developing by Gilead Sciences for the oral treatment of pancreatic and non-small cell lung cancers, and myeloproliferative disorders (including myelofibrosis, essential thrombocythaemia and polycythaemia vera).</div> </div> </div> </div> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/8OBZ1M4V3V " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> TAUROLIDINE </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a>   <a href=" /drug/8OBZ1M4V3V " uib-tooltip="view record details" target="_self"> <span class="font-monospace">8OBZ1M4V3V</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = "showLarge('0f620c0e-34e8-42cf-b5fe-4bc00bfe59b8', '723af8ac-41b4-4b64-a737-e3c671b21b86')" > <rendered id = '0f620c0e-34e8-42cf-b5fe-4bc00bfe59b8' ctx='mubvehgqou'> </rendered> <div> </div> </div> </div> <div class = "row col-md-12 hidden-sm hidden-xs"> </div> </div> <div class = "col-lg-1 col-md-1 col-sm-1 col-xs-1 text-center"> <ul class= "table-cell list-unstyled tools"> <li list-style="none"> <modal-button type= "export" structureid ="'723af8ac-41b4-4b64-a737-e3c671b21b86'" format="mol" format2="sdf" ></modal-button> </li> <li list-style="none"> <a ng-href="/structure?q=0f620c0e-34e8-42cf-b5fe-4bc00bfe59b8" target="_self" uib-tooltip="Structure Search" tooltip-placement="right" tooltip-append-to-body="true" aria-label="Structure Search"> <span class="sr-only"> Search for Structure </span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> <div class = "hidden-lg hidden-md col-sm-8 col-xs-8"> </div> <div class = "col-lg-8 col-md-7 col-sm-12 col-xs-12"> <div class = "row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2023) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA214520 </div> (2023) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=214520">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=214520</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2023 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA214520 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=214520">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=214520</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-achiral"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ACHIRAL)</span> </div> </div> <hr id="additional-details-separator"> <div class = 'row'><div class = 'col-md-3 col-sm-3 col-xs-3'><span id='additional-details-title'>Targets:</span></div><div class = 'col-md-9 col-sm-9 col-xs-9'><div class='fval'><div class='facet-val'><a title='Apoptosis' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FApoptosis"><div class='facet-val-text'>Apoptosis</div><span class="badge badge-light">155</span></a></div></div><div class='fval'><div class='facet-val'><a title='cell adhesion' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2Fcell adhesion"><div class='facet-val-text'>cell adhesion</div><span class="badge badge-light">5</span></a></div></div></div></div><hr id='additional-details-separator'> </div> </div> <div> <div class='text-block'>Taurolidine [bis(1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)-methane (TRD)], a product derived from the aminosulfoacid taurin, was first described as an anti-bacterial substance. Taurolidine is a small dimeric molecule with molecular weight 284. It comprises the semiconditional amino acid taurine. Taurolidine was originally designed as a broad-spectrum antibiotic. Taurolidine has a broad antimicrobial spectrum of activity that is effective against aerobes and anaerobes, Gram-negative and Gram-posi-tive bacteria as well as yeasts and moulds in vitro. Taurolidine is also effective against methicillin-resistant and vancomycin-resistant bacteria (MRSA, VISA and VRE). It was mainly used in the treatment of patients with peritonis as well as antiendoxic agent in patients with systematic inflammatory response syndrome. It has been shown to be an effective bactericidal agent against both aerobic and anaerobic bacteria. It is currently licensed for intraperitoneal use in several European countries for the treatment of peritonitis. The compound appears to be nontoxic and has an excellent safety record since its initial introduction over 30 years ago. Taurolidine also possesses antiadherence properties and has been shown in vivo to reduce the extent and severity of postoperative peritoneal adhesions. It also possesses a strong anti-inflammatory action. This action appears, at least in part, to arise through its ability to inactivate endotoxin. Inflammation-induced tumor development is well described in the literature. Taurolidine’s anti-inflammatory and antiadherence properties prompted an investigation to examine whether it has a role in antitumor therapy. Taurolidine induces cancer cell death through a variety of mechanisms. It appears to act through enhancing apoptosis, inhibiting angiogenesis and tumor adherence, downregulating proinflammatory cytokine and endotoxin levels, and stimulating the immune system in response to surgically induced trauma. Taurolidine is currently in preclinical development for neuroblastoma. In February 23, 2018 the U.S. Food and Drug Administration (FDA) granted orphan drug designation to taurolidine for the treatment of neuroblastoma. Taurolidine is a key component in the Neutrolin®, a novel anti-infective solution for the reduction and prevention of catheter-related infections and thrombosis in patients requiring central venous cathers in end stage renal disease. Neutrolin contains a mix of Taurolidine, Citrate and Heparin. Neutrolin is designed to: 1) Aid in the prevention of Catheter-Related Bloodstream Infections (CRBIs) and 2) Prevent catheter dysfunction (due to blood clotting).</div> </div> </div> </div> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/JVR38ZM64B " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> DAPRODUSTAT </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a class='info-rancho' data-toggle="popover" data-animation="true" data-placement="top" data-trigger="click focus" data-html="true" data-original-title="" title="" data-content="<span>Manually Curated </span>"><i class="fa fa-shield"></i></a>   <a href=" /drug/JVR38ZM64B " uib-tooltip="view record details" target="_self"> <span class="font-monospace">JVR38ZM64B</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = "showLarge('1d3dcc15-3074-4f4d-8b3b-2b96157d88c2', '459a1848-0914-4b2b-b262-210771e1abf8')" > <rendered id = '1d3dcc15-3074-4f4d-8b3b-2b96157d88c2' ctx='mubvehgqou'> </rendered> <div> </div> </div> </div> <div class = "row col-md-12 hidden-sm hidden-xs"> </div> </div> <div class = "col-lg-1 col-md-1 col-sm-1 col-xs-1 text-center"> <ul class= "table-cell list-unstyled tools"> <li list-style="none"> <modal-button type= "export" structureid ="'459a1848-0914-4b2b-b262-210771e1abf8'" format="mol" format2="sdf" ></modal-button> </li> <li list-style="none"> <a ng-href="/structure?q=1d3dcc15-3074-4f4d-8b3b-2b96157d88c2" target="_self" uib-tooltip="Structure Search" tooltip-placement="right" tooltip-append-to-body="true" aria-label="Structure Search"> <span class="sr-only"> Search for Structure </span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> <div class = "hidden-lg hidden-md col-sm-8 col-xs-8"> </div> <div class = "col-lg-8 col-md-7 col-sm-12 col-xs-12"> <div class = "row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2023) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA216951 </div> (2023) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216951">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216951</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2023 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA216951 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216951">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216951</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-achiral"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ACHIRAL)</span> </div> </div> <hr id="additional-details-separator"> <div class = 'row'><div class = 'col-md-3 col-sm-3 col-xs-3'><span id='additional-details-title'>Targets:</span></div><div class = 'col-md-9 col-sm-9 col-xs-9'><div class='fval'><div class='facet-val'><a title='Egl nine homolog 3' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FEgl nine homolog 3"><div class='facet-val-text'>Egl nine homolog 3</div><span class="badge badge-light">19</span></a></div></div><div class='fval'><div class='facet-val'><a title='Egl nine homolog 1' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FEgl nine homolog 1"><div class='facet-val-text'>Egl nine homolog 1</div><span class="badge badge-light">21</span></a></div></div><div class='fval'><div class='facet-val'><a title='Hypoxia-inducible factor prolyl hydroxylase 1' class="label label-primary loader" target='_self' ng-href="/substances?facet=Primary Target%2FHypoxia-inducible factor prolyl hydroxylase 1"><div class='facet-val-text'>Hypoxia-inducible factor prolyl hydroxylase 1</div><span class="badge badge-light">5</span></a></div></div></div></div><hr id='additional-details-separator'> <div class = 'row'><div class = 'col-md-3 col-sm-3 col-xs-3'><span id='additional-details-title'>Conditions:</span></div><div class = 'col-md-9 col-sm-9 col-xs-9'><div class='fval'><div class='facet-val'><a title='Anaemia' class="label label-primary loader" target='_self' ng-href="/substances?facet=Condition%2FAnaemia"><div class='facet-val-text'>Anaemia</div><span class="badge badge-light">1</span></a></div></div></div></div><hr id='additional-details-separator'> </div> </div> <div> <div class='text-block'>Daprodustat (GSK1278863) is a low nanomolar hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor, that increases HIF stability and action. In preclinical studies, Daprodustat stabilizes HIFα in cell lines, resulting in the production of increased levels of erythropoietin (EPO). In normal mice, a single dose of Daprodustat induced significant increases in circulating plasma EPO but only minimal increases in plasma vascular endothelial growth factor (VEGF-A) concentrations. Daprodustat significantly increased reticulocytes and red cell mass parameters in pre-clinical species following once-daily oral administration and has demonstrated an acceptable nonclinical toxicity profile supporting continued clinical development. In a phase 1 study, Daprodustat was well tolerated and increased erythropoietin (EPO) levels in apparently healthy individuals proportional to dose. In phase 2a studies in non–dialysis-dependent chronic kidney disease (NDD CKD) and end-stage renal disease Daprodustat 4-10 mg once-daily produced the dose-dependent increase in hemoglobin relative to placebo. The Phase III programme for the drug includes two studies evaluating its safety and efficacy compared to recombinant human erythropoietin in dialysis-dependent subjects with anemia associated with CKD (ASCEND-D) and in non-dialysis dependent patients with the condition (ASCEND-ND).</div> </div> </div> </div> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/ODU3ZAZ94J " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> ZAVEGEPANT </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a href=" /drug/ODU3ZAZ94J " uib-tooltip="view record details" target="_self"> <span class="font-monospace">ODU3ZAZ94J</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = "showLarge('a3a68cae-0f26-2fb1-54d2-f5d14f6fe9dd', 'ed010b76-8c74-473b-9b27-df71858edffb')" > <rendered id = 'a3a68cae-0f26-2fb1-54d2-f5d14f6fe9dd' ctx='mubvehgqou'> </rendered> <div> </div> </div> </div> <div class = "row col-md-12 hidden-sm hidden-xs"> </div> </div> <div class = "col-lg-1 col-md-1 col-sm-1 col-xs-1 text-center"> <ul class= "table-cell list-unstyled tools"> <li list-style="none"> <modal-button type= "export" structureid ="'ed010b76-8c74-473b-9b27-df71858edffb'" format="mol" format2="sdf" ></modal-button> </li> <li list-style="none"> <a ng-href="/structure?q=a3a68cae-0f26-2fb1-54d2-f5d14f6fe9dd" target="_self" uib-tooltip="Structure Search" tooltip-placement="right" tooltip-append-to-body="true" aria-label="Structure Search"> <span class="sr-only"> Search for Structure </span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> <div class = "hidden-lg hidden-md col-sm-8 col-xs-8"> </div> <div class = "col-lg-8 col-md-7 col-sm-12 col-xs-12"> <div class = "row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2023) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA216386 </div> (2023) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216386">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216386</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2023 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA216386 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216386">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216386</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-absolute"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ABSOLUTE)</span> </div> </div> <hr id="additional-details-separator"> </div> </div> </div> </div> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/XD423NK2WO " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> Flotufolastat F-18 Gallium </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a href=" /drug/XD423NK2WO " uib-tooltip="view record details" target="_self"> <span class="font-monospace">XD423NK2WO</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = "showLarge('d970b1d3-8d2b-e3fb-3c99-d2158e26e434', '0d402eca-a502-4acb-92ae-9b0b9f1e4cba')" > <rendered id = 'd970b1d3-8d2b-e3fb-3c99-d2158e26e434' ctx='mubvehgqou'> </rendered> <div> </div> </div> </div> <div class = "row col-md-12 hidden-sm hidden-xs"> </div> </div> <div class = "col-lg-1 col-md-1 col-sm-1 col-xs-1 text-center"> <ul class= "table-cell list-unstyled tools"> <li list-style="none"> <modal-button type= "export" structureid ="'0d402eca-a502-4acb-92ae-9b0b9f1e4cba'" format="mol" format2="sdf" ></modal-button> </li> <li list-style="none"> <a ng-href="/structure?q=d970b1d3-8d2b-e3fb-3c99-d2158e26e434" target="_self" uib-tooltip="Structure Search" tooltip-placement="right" tooltip-append-to-body="true" aria-label="Structure Search"> <span class="sr-only"> Search for Structure </span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> <div class = "hidden-lg hidden-md col-sm-8 col-xs-8"> </div> <div class = "col-lg-8 col-md-7 col-sm-12 col-xs-12"> <div class = "row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2023) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA216023 </div> (2023) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216023">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216023</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2023 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA216023 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216023">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216023</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-absolute"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ABSOLUTE)</span> </div> </div> <hr id="additional-details-separator"> </div> </div> </div> </div> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/8E05T07Z6W " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> IPTACOPAN </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a href=" /drug/8E05T07Z6W " uib-tooltip="view record details" target="_self"> <span class="font-monospace">8E05T07Z6W</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = "showLarge('efaed5fe-e472-c107-a6bf-1ac71f534136', 'd4c2cc98-9f33-4545-9e8d-b47f37f58ad5')" > <rendered id = 'efaed5fe-e472-c107-a6bf-1ac71f534136' ctx='mubvehgqou'> </rendered> <div> </div> </div> </div> <div class = "row col-md-12 hidden-sm hidden-xs"> </div> </div> <div class = "col-lg-1 col-md-1 col-sm-1 col-xs-1 text-center"> <ul class= "table-cell list-unstyled tools"> <li list-style="none"> <modal-button type= "export" structureid ="'d4c2cc98-9f33-4545-9e8d-b47f37f58ad5'" format="mol" format2="sdf" ></modal-button> </li> <li list-style="none"> <a ng-href="/structure?q=efaed5fe-e472-c107-a6bf-1ac71f534136" target="_self" uib-tooltip="Structure Search" tooltip-placement="right" tooltip-append-to-body="true" aria-label="Structure Search"> <span class="sr-only"> Search for Structure </span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> <div class = "hidden-lg hidden-md col-sm-8 col-xs-8"> </div> <div class = "col-lg-8 col-md-7 col-sm-12 col-xs-12"> <div class = "row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2023) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA218276 </div> (2023) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=218276">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=218276</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2023 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA218276 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=218276">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=218276</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-absolute"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ABSOLUTE)</span> </div> </div> <hr id="additional-details-separator"> </div> </div> </div> </div> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/JNA39I7ZVB " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> PIRTOBRUTINIB </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a href=" /drug/JNA39I7ZVB " uib-tooltip="view record details" target="_self"> <span class="font-monospace">JNA39I7ZVB</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = "showLarge('ac81bd2e-3091-a808-72af-1b10878b0292', '7a2fc2c6-5022-4a36-94f5-b3983d1db7d9')" > <rendered id = 'ac81bd2e-3091-a808-72af-1b10878b0292' ctx='mubvehgqou'> </rendered> <div> </div> </div> </div> <div class = "row col-md-12 hidden-sm hidden-xs"> </div> </div> <div class = "col-lg-1 col-md-1 col-sm-1 col-xs-1 text-center"> <ul class= "table-cell list-unstyled tools"> <li list-style="none"> <modal-button type= "export" structureid ="'7a2fc2c6-5022-4a36-94f5-b3983d1db7d9'" format="mol" format2="sdf" ></modal-button> </li> <li list-style="none"> <a ng-href="/structure?q=ac81bd2e-3091-a808-72af-1b10878b0292" target="_self" uib-tooltip="Structure Search" tooltip-placement="right" tooltip-append-to-body="true" aria-label="Structure Search"> <span class="sr-only"> Search for Structure </span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> <div class = "hidden-lg hidden-md col-sm-8 col-xs-8"> </div> <div class = "col-lg-8 col-md-7 col-sm-12 col-xs-12"> <div class = "row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2023) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA216059 </div> (2023) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216059">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216059</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2023 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA216059 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216059">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216059</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-absolute"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ABSOLUTE)</span> </div> </div> <hr id="additional-details-separator"> </div> </div> </div> </div> <div class="panel panel-default sub-list"> <div class="panel-heading prot-title"> <div class = "row"> <div class = "col-md-9 col-sm-9 col-xs-9"> <a id="card-title" href=" /drug/7VYX4ELWQM " uib-tooltip="View Record Details" tooltip-placement="bottom-left" target="_self"> <h3 class="title-name"> Perfluorohexyloctane </h3> <div class="btn btn-url font-monospace"> MORE DETAILS <i class="fa fa-arrow-circle-right" aria-hidden="true"></i> </div> </a> </div> <div class = "col-md-3 col-sm-3 col-xs-3 prot-approvID"> <h4 class= "text-right"> <a href=" /drug/7VYX4ELWQM " uib-tooltip="view record details" target="_self"> <span class="font-monospace">7VYX4ELWQM</span> </a> </h4> </div> </div> </div> <div class= "panel-body list-item"> <div class = "row"> <div class = "col-lg-3 col-md-4 col-sm-11 col-xs-11 text-center autocursor"> <div class = "row"> <div class = "magnify" ng-click = "showLarge('a52f0916-a0cd-3bfa-6d97-40be30902c56', '0f1b77b8-5acd-4db3-b02d-7b962908b8ee')" > <rendered id = 'a52f0916-a0cd-3bfa-6d97-40be30902c56' ctx='mubvehgqou'> </rendered> <div> </div> </div> </div> <div class = "row col-md-12 hidden-sm hidden-xs"> </div> </div> <div class = "col-lg-1 col-md-1 col-sm-1 col-xs-1 text-center"> <ul class= "table-cell list-unstyled tools"> <li list-style="none"> <modal-button type= "export" structureid ="'0f1b77b8-5acd-4db3-b02d-7b962908b8ee'" format="mol" format2="sdf" ></modal-button> </li> <li list-style="none"> <a ng-href="/structure?q=a52f0916-a0cd-3bfa-6d97-40be30902c56" target="_self" uib-tooltip="Structure Search" tooltip-placement="right" tooltip-append-to-body="true" aria-label="Structure Search"> <span class="sr-only"> Search for Structure </span> <span class="fa fa-search success"></span> </a> </li> </ul> </div> <div class = "hidden-lg hidden-md col-sm-8 col-xs-8"> </div> <div class = "col-lg-8 col-md-7 col-sm-12 col-xs-12"> <div class = "row" id="commonlistdetails-status"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title">Status:</span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox" id = "devstatus"> <span id="icon-status" class="flexbox"> <i class="fa fa-thumbs-up" aria-hidden="true"></i> </span> <span id="label-status" title='US Approved Rx'> US Approved Rx (2023) </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA216675 </div> (2023) <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216675">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216675</a> </div> </div> </info-popup> </div> <div class = "col-md-3 col-sm-3 col-xs-3"> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text flexbox"> <span id="label-status"> First approved in 2023 </span> <info-popup type="auto" class="flexbox"> <div class="info-popup-container"> <div> <span class="pop-sub-key">Source:</span> </div> <div class="pop-sub-val"> NDA216675 </div> <div> <span class="pop-sub-key">Source URL:</span> </div> <div class="pop-sub-val"> <a href="https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216675">https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216675</a> </div> </div> </info-popup> </div> </div> <hr id="additional-details-separator"> <div class = "row"> <div class = "col-md-3 col-sm-3 col-xs-3"> <span id="additional-details-title"> Class (Stereo): </span> </div> <div class = "col-md-9 col-sm-9 col-xs-9 break-text"> <span class="list-view-badge" id="label-achiral"> <i class="fa fa-circle" aria-hidden="true"></i> </span> <span class="list-view-badge bold-inline">CHEMICAL (ACHIRAL)</span> </div> </div> <hr id="additional-details-separator"> </div> </div> </div> </div> </div> <div class = "row hidden-xs" ng-if="gridView" id ="grid"> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/80VUN7L00C" uib-tooltip="view record details" target="_self"> <code>80VUN7L00C</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/80VUN7L00C" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of ENMETAZOBACTAM" src='/img/6341bdaf-9724-43e0-90da-0fe88a4e728a.svg?size=200&context=mubvehgqou'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-success label-offset">ABSOLUTE</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="ENMETAZOBACTAM"> <a href="/substance/80VUN7L00C" target="_self"> ENMETAZOBACTAM </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'6341bdaf-9724-43e0-90da-0fe88a4e728a'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=6341bdaf-9724-43e0-90da-0fe88a4e728a" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/2OYE00PC25" uib-tooltip="view record details" target="_self"> <code>2OYE00PC25</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/2OYE00PC25" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of RITLECITINIB" src='/img/5f671d47-1f16-4668-b15d-7aa529e0ef6b.svg?size=200&context=mubvehgqou'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-success label-offset">ABSOLUTE</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="RITLECITINIB"> <a href="/substance/2OYE00PC25" target="_self"> RITLECITINIB </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'5f671d47-1f16-4668-b15d-7aa529e0ef6b'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=5f671d47-1f16-4668-b15d-7aa529e0ef6b" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/6O01GMS00P" uib-tooltip="view record details" target="_self"> <code>6O01GMS00P</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/6O01GMS00P" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of MOMELOTINIB" src='/img/dd382f7f-e8a4-45c6-a7d5-9e236a823d20.svg?size=200&context=mubvehgqou'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-primary label-offset">ACHIRAL</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="MOMELOTINIB"> <a href="/substance/6O01GMS00P" target="_self"> MOMELOTINIB </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'dd382f7f-e8a4-45c6-a7d5-9e236a823d20'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=dd382f7f-e8a4-45c6-a7d5-9e236a823d20" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/8OBZ1M4V3V" uib-tooltip="view record details" target="_self"> <code>8OBZ1M4V3V</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/8OBZ1M4V3V" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of TAUROLIDINE" src='/img/0f620c0e-34e8-42cf-b5fe-4bc00bfe59b8.svg?size=200&context=mubvehgqou'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-primary label-offset">ACHIRAL</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="TAUROLIDINE"> <a href="/substance/8OBZ1M4V3V" target="_self"> TAUROLIDINE </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'0f620c0e-34e8-42cf-b5fe-4bc00bfe59b8'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=0f620c0e-34e8-42cf-b5fe-4bc00bfe59b8" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/JVR38ZM64B" uib-tooltip="view record details" target="_self"> <code>JVR38ZM64B</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/JVR38ZM64B" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of DAPRODUSTAT" src='/img/1d3dcc15-3074-4f4d-8b3b-2b96157d88c2.svg?size=200&context=mubvehgqou'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-primary label-offset">ACHIRAL</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="DAPRODUSTAT"> <a href="/substance/JVR38ZM64B" target="_self"> DAPRODUSTAT </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'1d3dcc15-3074-4f4d-8b3b-2b96157d88c2'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=1d3dcc15-3074-4f4d-8b3b-2b96157d88c2" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/ODU3ZAZ94J" uib-tooltip="view record details" target="_self"> <code>ODU3ZAZ94J</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/ODU3ZAZ94J" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of ZAVEGEPANT" src='/img/a3a68cae-0f26-2fb1-54d2-f5d14f6fe9dd.svg?size=200&context=mubvehgqou'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-success label-offset">ABSOLUTE</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="ZAVEGEPANT"> <a href="/substance/ODU3ZAZ94J" target="_self"> ZAVEGEPANT </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'a3a68cae-0f26-2fb1-54d2-f5d14f6fe9dd'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=a3a68cae-0f26-2fb1-54d2-f5d14f6fe9dd" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/XD423NK2WO" uib-tooltip="view record details" target="_self"> <code>XD423NK2WO</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/XD423NK2WO" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of Flotufolastat F-18 Gallium" src='/img/d970b1d3-8d2b-e3fb-3c99-d2158e26e434.svg?size=200&context=mubvehgqou'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-success label-offset">ABSOLUTE</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="Flotufolastat F-18 Gallium"> <a href="/substance/XD423NK2WO" target="_self"> Flotufolastat F-18 Gallium </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'d970b1d3-8d2b-e3fb-3c99-d2158e26e434'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=d970b1d3-8d2b-e3fb-3c99-d2158e26e434" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/8E05T07Z6W" uib-tooltip="view record details" target="_self"> <code>8E05T07Z6W</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/8E05T07Z6W" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of IPTACOPAN" src='/img/efaed5fe-e472-c107-a6bf-1ac71f534136.svg?size=200&context=mubvehgqou'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-success label-offset">ABSOLUTE</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="IPTACOPAN"> <a href="/substance/8E05T07Z6W" target="_self"> IPTACOPAN </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'efaed5fe-e472-c107-a6bf-1ac71f534136'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=efaed5fe-e472-c107-a6bf-1ac71f534136" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/JNA39I7ZVB" uib-tooltip="view record details" target="_self"> <code>JNA39I7ZVB</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/JNA39I7ZVB" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of PIRTOBRUTINIB" src='/img/ac81bd2e-3091-a808-72af-1b10878b0292.svg?size=200&context=mubvehgqou'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-success label-offset">ABSOLUTE</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="PIRTOBRUTINIB"> <a href="/substance/JNA39I7ZVB" target="_self"> PIRTOBRUTINIB </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'ac81bd2e-3091-a808-72af-1b10878b0292'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=ac81bd2e-3091-a808-72af-1b10878b0292" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> <div class = "col-md-3 thumb-col"> <div class="panel panel-default"> <div class="panel-heading"> <p data-toggle="tooltip" title="Approval ID"> <a class="text-right" href="/substance/7VYX4ELWQM" uib-tooltip="view record details" target="_self"> <code>7VYX4ELWQM</code></a> <br> </p> </div> <div class="panel-body struc-img"> <a href="/substance/7VYX4ELWQM" uib-tooltip="view record details" target="_self"> <img class = "struc-thumb img-responsive" alt="Structure of Perfluorohexyloctane" src='/img/a52f0916-a0cd-3bfa-6d97-40be30902c56.svg?size=200&context=mubvehgqou'> </a> <div class = "row stereo"> <div class = "col-md-10"> <span class="label label-primary label-offset">ACHIRAL</span> </div> </div> </div> <div> </div> <div class = "panel-footer nameDiv" data-toggle="tooltip" title="Perfluorohexyloctane"> <a href="/substance/7VYX4ELWQM" target="_self"> Perfluorohexyloctane </a> <div class = "row"> <div class = "col-md-12 text-center"> <ul class= "list-inline list-unstyled tools"> <li> <modal-button type= "export" structureid ="'a52f0916-a0cd-3bfa-6d97-40be30902c56'" format="sdf" ></modal-button> </li> <li> <a ng-href="/structure?q=a52f0916-a0cd-3bfa-6d97-40be30902c56" target="_self" uib-tooltip="Structure Search" aria-label="Structure Search"> <span class="fa fa-search fa-2x success"></span></a> </li> </ul> </div> </div> </div> </div> </div> </div> </div> </div>  <div class = "col-md-18" id="showingnumber-pagination-sort"> <div class="col-md-12 col-sm-12 col-xs-12" id="showingnumber-export"> <h4>Showing <span id="record-count" class="label label-default"> 1 - 10 </span> of <span id="record-count" class="label label-default"> 12702 </span> results </h4> <div ng-controller="TypeAheadController" class="pull-right" id="search-within"> <div ng-cloak ="" ng-show="loadingSuggest" id="loading-suggest"> <i class="fa fa-refresh fa-spin fa-fw"></i> </div> <form class="form-inline main-search" role="search"> <div class="input-group"> <input type="text" class="form-control" id="search" aria-label="Search in Current Subset" title="Search in Current Subset" placeholder= "Search in Current Subset..." ng-model = "query" typeahead-popup-template-url="app/assets/templates/elements/suggest-popup.html" uib-typeahead="r.d as r.d for r in getSuggestions($viewValue)" 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firststatus.needsReload = true; if (firststatus.count < firststatus.thisPage) { $('.placeholder-content').html('<div>Loading ... </div>' + '<div class="progress multi-progress">' + '<div id="loading-bar1" class="progress-bar progress-bar-striped active" role="progressbar" aria-valuenow="0" aria-valuemin="0" aria-valuemax="100">' + '</div>' + +'</div>'); } $('#searching').html('<i class="fa fa-spinner fa-spin"></i> searching...'); //var delay = 0; var checkStatus; var timer; $('#loading').on('hidden.bs.modal', function (e) { window.clearInterval(timer); }); var onDetermined = function () { //window.clearInterval(timer); $('#searching').html(''); //$('#loading').modal('hide'); if (firststatus.needsReload) { $('#searching').html('Reloading search ...'); location.reload(true); } }; var onLoadedMore = function (data) { // loading vs searching.. if (data.total) { if (data.count > firststatus.thisPage || data.finished) { if (firststatus.needsReload) { location.reload(true); } } var pct = Math.floor(100.0 * data.count / firststatus.thisPage + 0.0); pct = Math.min(pct, 100); var loadedPage = Math.floor(data.count / firststatus.rowsPerPage); var waitPage = Math.floor(firststatus.thisPage / firststatus.rowsPerPage); $("#loading-bar1").html(pct + "%"); $("#loading-bar1").width(pct + "%"); $("#loading-bar1").attr("aria-valuenow", pct); } else { $('#searching').html('<i class="fa fa-spinner fa-spin"></i> searching... ' + data.count + ' matches'); } }; checkStatus = function () { /* if (delay == 0) { window.clearInterval(timer); delay = 500; timer = window.setInterval(checkStatus, delay); }*/ $.ajax(firststatus.url, { dataType: 'json', }).done(function (status) { if (!firststatus.determined && status.determined) { onDetermined(status); } else { onLoadedMore(status); //console.log(status); checkStatus(); } }).error(function () { //window.clearInterval(timer); }); }; //timer = window.setInterval(checkStatus, delay); checkStatus(); } } }); $(document).ready( function() { var chartJsonUrl = '/chart?searchId=098a990de2e0850674cc651c659fab0f0603f35c&facetField=Treatment+Modality'; $.getJSON(chartJsonUrl, function (data) { //'Drugs' or 'Substances' section name //actually, deprecated at the moment, but the code'll stay just in case var sectionName = 'Substances' //console.log(data.labels); data.title = { text: "Number of " + sectionName + " by Treatment Modality" }; //console.log(data.title) data.chart = { type: 'bar' }; data.credits = { enabled: false }; data.navigation = { buttonOptions: { theme: { useHTML: true } } }; data.lang = { printChart: 'Print Chart', saveChart: 'Save Chart...' }; data.exporting = { allowHTML: true, buttons: { contextButton: { enabled: false }, exportButton: { text: '<i class="fa fa-download" aria-hidden="true"></i>', _titleKey: 'saveChart', // Use only the download related menu items from the default context button menuItems: Highcharts.getOptions().exporting.buttons.contextButton.menuItems.splice(2) }, printButton: { text: '<i class="fa fa-print" aria-hidden="true"></i>', _titleKey: 'printChart', onclick: function () { this.print(); } } } }; data.plotOptions = { bar: { datalabels: { enabled: true }, pointWidth: 30, tooltip: { pointFormat: '<b>{point.y}</b>' } } }; data.xAxis = { categories: data.labels, lineWidth: 0, labels: { style: {"fontSize": "14px"} } }; data.yAxis = { title: { text: null }, labels: { style: {"fontSize": "14px"} }, allowDecimals: false }; data.series = [{ data: data.values, name: "Count", showInLegend: false }]; //console.log(data); $(function (data) { //if no labels -- hide chart container if (data.labels.length < 1) { $('#treatment-modality-chart').hide(); //remove flickity carousel cell as well $('.carousel').flickity().flickity( 'remove', $('#treatment-modality-chart').parent(".carousel-cell")); //also check if there are any other cells left - if not, remove carousel if($(".carousel-cell").length === 0){ $(".carousel").remove(); }; } (function (H, data) { //this function renders a chart with fa-icons H.wrap(H.Renderer.prototype, 'label', function (proceed, str, x, y, shape, anchorX, anchorY, useHTML) { if (/class="fa/.test(str)) useHTML = true; //run original proceed method return proceed.apply(this, [].slice.call(arguments, 1)); }); }(Highcharts, data)); $('#treatment-modality-chart').highcharts(data); }(data)); }) }); $(document).ready( function(){ $.getJSON('/chart?searchId=098a990de2e0850674cc651c659fab0f0603f35c&facetField=Approval+Year' , function(data){ //Drugs or Substances section name var sectionName = 'Substances' //console.log(sectionName) //console.log(data); var mergedLabels = []; var mergedData = []; var arrayLength = data.labels.length; var kvs = []; for (var i = 0; i < data.labels.length; i++){ var kv={k:data.labels[i], v:data.values[i]}; kvs.push(kv); } var mergedData=_.chain(kvs) .map(function(kv){ kv.k=Math.trunc((kv.k-0)/10)*10; //console.log(kv); return kv; }) .groupBy("k") .toPairs() .map(function(grp){ //console.log(grp); var decade=grp[0]; var count=_.sumBy(grp[1], "v"); return {k:decade, v: count}; }) .value() .sort(function(a,b){return b.k-a.k;}); var values=_.chain(mergedData) .map(function(kv){return kv.v;}) .value(); var keys=_.chain(mergedData) .map(function(kv){return kv.k;}) .value(); //console.log(mergedData); data.title = { text : "Number of " + sectionName + " by Approval Decade" }; //console.log(data.title) data.chart = { type : 'bar' }; data.credits = { enabled: false }; data.navigation = { buttonOptions: { theme: { useHTML: true } } }; data.lang = { printChart: 'Print Chart', saveChart: 'Save Chart...' }; data.exporting = { allowHTML: true, buttons: { contextButton: { enabled: false }, exportButton: { text: '<i class="fa fa-download" aria-hidden="true"></i>', _titleKey: 'saveChart', // Use only the download related menu items from the default context button menuItems: Highcharts.getOptions().exporting.buttons.contextButton.menuItems.splice(2) }, printButton: { text: '<i class="fa fa-print" aria-hidden="true"></i>', _titleKey: 'printChart', onclick: function() { this.print(); } } } }; data.plotOptions = { bar:{datalabels:{ enabled: true }, pointWidth: 30, tooltip: { pointFormat: '<b>{point.y}</b>' } }, columnrange: { dataGrouping : { forced : true } } }; data.xAxis = { categories: keys, lineWidth: 0, labels: { style: {"fontSize":"14px"} }, }; data.yAxis = { title: { text: null }, labels: { style: {"fontSize":"14px"} }, allowDecimals : false }; data.series = [{ data: values, name: "Count", showInLegend: false, }]; //console.log(data.labels); //console.log(data.values); $(function(data) { //if no labels -- remove chart container if(data.labels.length < 1){ $('#approval-date-chart').hide(); //remove flickity carousel cell as well $('.carousel').flickity().flickity( 'remove', $('#approval-date-chart').parent(".carousel-cell")); //also check if there are any other cells left - if not, remove carousel if($(".carousel-cell").length === 0){ $(".carousel").remove(); }; } (function (H,data) { //this function renders a chart with fa-icons H.wrap(H.Renderer.prototype, 'label', function (proceed, str, x, y, shape, anchorX, anchorY, useHTML) { if(/class="fa/.test(str)) useHTML = true; //run original proceed method return proceed.apply(this, [].slice.call(arguments, 1)); }); }(Highcharts,data)); $('#approval-date-chart').highcharts(data); }(data)); }) }); </script> <mol-export></mol-export> </div> <script> $(document).ready(function(){ try{ $("table.gsrs-datatable").DataTable( { "lengthMenu": [[5, 20, 100, -1], [5, 20, 100, "All"]], language: { search: "", searchPlaceholder: "Search..." }, "aaSorting": [], "scrollX": true }); }catch(e){ console.log(e); } $('.unloaded').removeClass("unloaded"); $('body').scrollspy({ offset:300, target:".sidebar-inner" }); $('#affix').affix({ offset: { top: 50 } }); $(".dataTables_filter input").addClass("form-control"); }); var onResize = function() { // apply dynamic padding at the top of the body according to the fixed navbar height $("body").css("padding-top", $(".navbar-fixed-top").height()); }; // attach the function to the window resize event $(window).resize(onResize); // call it also when the page is ready after load or reload $(function() { onResize(); 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var _this=this; console.log("not toggle on"); setTimeout(function(){ $(_this).popover("show"); },10); resetBindings(); }); $('.toggle-on').click(function(){ $(this).removeClass("toggle-on"); $(this).popover('hide'); resetBindings(); }); $('[data-toggle="popover"]:not(.toggle-force)') .popover({ trigger: "manual" , html: true, animation:false}) .on("mouseenter", function () { if(false){ var _this = this; var t=Math.random() + ""; $(_this).attr("fade_id",t); $(this).popover("show"); $(".popover").on("mouseleave", function () { setTimeout(function () { if(!$(_this).hasClass("toggle-on")){ $(_this).popover('hide'); } },800); }); } }) .on("mouseleave", function () { if(false){ var _this = this; if(!$(_this).hasClass("toggle-on")){ var t=Math.random() + ""; $(_this).attr("fade_id",t); setTimeout(function () { if (!$(".popover:hover").length) { if($(_this).attr("fade_id") == t){ $(_this).popover("hide"); } } }, 800); } } }); }; resetBindings(); document.body.addEventListener("click", function(e){ if(!$(e.target).parents(".popover").length){ $('[data-toggle="popover"]').popover('hide'); 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