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Chimpanzee reservoirs of pandemic and nonpandemic HIV-1 - PubMed
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data-collections-open-panel-url-hash="#open-collections-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to Collections </h3> <form id="collections-action-panel-form" class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-existing-collections-url="/list-existing-collections/" data-add-to-existing-collection-url="/add-to-existing-collection/" data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-myncbi-max-collection-name-length="100" data-add-to-collection-max-amount="1000" data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"> <input type="hidden" name="csrfmiddlewaretoken" value="C7w9IVUmVp5TYWB0ZjQUbGh1h3ouLH680BvylK4uLCZ2kF6PwGSLKfRrbuEKuZxO"> <div class="choice-group" role="radiogroup"> <ul class="radio-group-items"> <li> <input type="radio" id="collections-action-panel-new" class="collections-new" name="collections" value="new" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_new"> <label for="collections-action-panel-new">Create a new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="C7w9IVUmVp5TYWB0ZjQUbGh1h3ouLH680BvylK4uLCZ2kF6PwGSLKfRrbuEKuZxO"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="C7w9IVUmVp5TYWB0ZjQUbGh1h3ouLH680BvylK4uLCZ2kF6PwGSLKfRrbuEKuZxO"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="C7w9IVUmVp5TYWB0ZjQUbGh1h3ouLH680BvylK4uLCZ2kF6PwGSLKfRrbuEKuZxO"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="C7w9IVUmVp5TYWB0ZjQUbGh1h3ouLH680BvylK4uLCZ2kF6PwGSLKfRrbuEKuZxO"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="16728595"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" 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data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="C7w9IVUmVp5TYWB0ZjQUbGh1h3ouLH680BvylK4uLCZ2kF6PwGSLKfRrbuEKuZxO"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio" id="collections-action-dialog-new" class="collections-new" name="collections" value="new" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio" id="collections-action-dialog-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label><input type="text" name="add-to-new-collection" id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="collections_button" data-ga-action="create_collection" data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label"> Choose a collection: </label><select id="collections-action-dialog-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="collections_button" data-ga-action="select_collection" data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="collections_button" data-ga-action="click" data-ga-label="add"> Add </button><button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="collections_button" data-ga-action="click" data-ga-label="cancel"> Cancel </button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" 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href="/?term=Keele+BF&cauthor_id=16728595" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Brandon F Keele">Brandon F Keele</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Van+Heuverswyn+F&cauthor_id=16728595" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Fran Van Heuverswyn">Fran Van Heuverswyn</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Li+Y&cauthor_id=16728595" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Yingying Li">Yingying 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class="authors-list-item "><a class="full-name" href="/?term=Loul+S&cauthor_id=16728595" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Severin Loul">Severin Loul</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ngole+EM&cauthor_id=16728595" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Eitel Mpoudi Ngole">Eitel Mpoudi Ngole</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Bienvenue+Y&cauthor_id=16728595" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Yanga Bienvenue">Yanga Bienvenue</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Delaporte+E&cauthor_id=16728595" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Eric Delaporte">Eric Delaporte</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Brookfield+JF&cauthor_id=16728595" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="John F Y Brookfield">John F Y Brookfield</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Sharp+PM&cauthor_id=16728595" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Paul M Sharp">Paul M Sharp</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Shaw+GM&cauthor_id=16728595" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="George M Shaw">George M Shaw</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Peeters+M&cauthor_id=16728595" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Martine Peeters">Martine Peeters</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Hahn+BH&cauthor_id=16728595" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Beatrice H Hahn">Beatrice H Hahn</a></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">16728595</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC2442710&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC2442710/" data-ga-category="full_text" data-ga-action="PMCID" > PMC2442710 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1126/science.1126531&id_type=DOI" href="https://doi.org/10.1126/science.1126531" data-ga-category="full_text" data-ga-action="DOI" > 10.1126/science.1126531 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/16728595/citations/" data-citation-style="nlm" data-pubmed-format-link="/16728595/export/"><span class="button-label">Cite</span></button><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> Human immunodeficiency virus type 1 (HIV-1), the cause of human acquired immunodeficiency syndrome (AIDS), is a zoonotic infection of staggering proportions and social impact. Yet uncertainty persists regarding its natural reservoir. The virus most closely related to HIV-1 is a simian immunodeficiency virus (SIV) thus far identified only in captive members of the chimpanzee subspecies Pan troglodytes troglodytes. Here we report the detection of SIVcpz antibodies and nucleic acids in fecal samples from wild-living P. t. troglodytes apes in southern Cameroon, where prevalence rates in some communities reached 29 to 35%. By sequence analysis of endemic SIVcpz strains, we could trace the origins of pandemic (group M) and nonpandemic (group N) HIV-1 to distinct, geographically isolated chimpanzee communities. These findings establish P. t. troglodytes as a natural reservoir of HIV-1. </p> </div> </div> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" ga_category="literature_resources" ga_action="disclaimer_link" ga_label="under_abstract">PubMed Disclaimer</a> </p> <div class="figures" id="figures"> <h2 class="title"> Figures </h2> <div class="figures-list" id="slides-container" itemscope itemtype="http://schema.org/ImageGallery"> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="0" data-label-slug="fig-1"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1004/2442710/8c21c5bbea12/nihms55584f1.jpg" itemprop="contentUrl" aria-describedby="figure-caption-0" role="button" data-image-width="800" data-image-height="828" data-image-alt="Fig. 1" data-pmc-id="PMC2442710" data-figure-id="F1"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-0" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1004/2442710/07120c900774/nihms55584f1.gif" alt="Fig. 1" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="800"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="828"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Fig. 1 </p> </strong> <div class="figure-caption-contents"><p> Natural ranges of the four… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Fig. 1 </p> </strong> <div class="figure-caption-contents"><p> Natural ranges of the four chimpanzee subspecies (top) and locations of wild chimpanzee… </p></div> </div> <figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Fig. 1 </strong> <div class="figure-caption-contents">Natural ranges of the four chimpanzee subspecies (top) and locations of wild chimpanzee study sites WE, MT, DG, DP, BQ, EK, CP, BB, MB, and LB in southern Cameroon (inset and bottom). Field sites with endemic SIVcpz<i>Ptt</i> infection are color-coded to correspond with the SIVcpz<i>Ptt</i> lineages shown in Figs. 3 and 4.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="1" data-label-slug="fig-2"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1004/2442710/90de99befa1f/nihms55584f2.jpg" itemprop="contentUrl" aria-describedby="figure-caption-1" role="button" data-image-width="800" data-image-height="369" data-image-alt="Fig. 2" data-pmc-id="PMC2442710" data-figure-id="F2"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-1" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1004/2442710/595221be97f1/nihms55584f2.gif" alt="Fig. 2" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="800"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="369"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Fig. 2 </p> </strong> <div class="figure-caption-contents"><p> Detection of SIVcpz antibodies in… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Fig. 2 </p> </strong> <div class="figure-caption-contents"><p> Detection of SIVcpz antibodies in chimpanzee fecal samples. Fecal samples from wild-living chimpanzees… </p></div> </div> <figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Fig. 2 </strong> <div class="figure-caption-contents">Detection of SIVcpz antibodies in chimpanzee fecal samples. Fecal samples from wild-living chimpanzees were tested by enhanced chemiluminescent Western blot using HIV-1 antigen–containing strips. Samples are numbered, with letters indicating their collection site as shown in Fig. 1. Samples from the same individual (ID) are grouped. Asterisks indicate two antibody-negative but virion RNA–positive samples (also see table S3). Molecular weights of HIV-1 proteins are indicated. The banding patterns of plasma from HIV-1–infected (Pos) and –uninfected (Neg) humans are shown as controls.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="2" data-label-slug="fig-3"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1004/2442710/fa8a90d2738d/nihms55584f3.jpg" itemprop="contentUrl" aria-describedby="figure-caption-2" role="button" data-image-width="800" data-image-height="640" data-image-alt="Fig. 3" data-pmc-id="PMC2442710" data-figure-id="F3"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-2" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1004/2442710/0cad6714ac50/nihms55584f3.gif" alt="Fig. 3" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="800"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="640"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Fig. 3 </p> </strong> <div class="figure-caption-contents"><p> Phylogenetic analysis of SIVcpz <i> Ptt… </i> </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Fig. 3 </p> </strong> <div class="figure-caption-contents"><p> Phylogenetic analysis of SIVcpz <i> Ptt </i> strains from wild <i> P. t. troglodytes </i> apes. Newly… </p></div> </div> <figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Fig. 3 </strong> <div class="figure-caption-contents">Phylogenetic analysis of SIVcpz<i>Ptt</i> strains from wild <i>P. t. troglodytes</i> apes. Newly identified SIVcpz<i>Ptt</i> strains are highlighted by colors reflecting their collection sites (Fig. 1). Representative strains of HIV-1 groups M, N, and O and SIVcpz<i>Pts</i> (TAN1, TAN2, TAN3, and ANT) are shown. Trees were inferred by the Bayesian method; numbers on nodes are percentage posterior probabilities (only values above 95% are shown). The scale bars represent 0.05 and 0.1 substitutions per site. Pol, polymerase; gp41, envelope transmembrane protein.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="3" data-label-slug="fig-4"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1004/2442710/8bed3b2045bd/nihms55584f4.jpg" itemprop="contentUrl" aria-describedby="figure-caption-3" role="button" data-image-width="800" data-image-height="970" data-image-alt="Fig. 4" data-pmc-id="PMC2442710" data-figure-id="F4"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-3" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1004/2442710/7d52d3f48e8d/nihms55584f4.gif" alt="Fig. 4" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="800"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="970"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Fig. 4 </p> </strong> <div class="figure-caption-contents"><p> Evolutionary relationships of SIVcpz and… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Fig. 4 </p> </strong> <div class="figure-caption-contents"><p> Evolutionary relationships of SIVcpz and HIV-1 strains based on full-length sequences. Trees were… </p></div> </div> <figcaption id="figure-caption-3" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Fig. 4 </strong> <div class="figure-caption-contents">Evolutionary relationships of SIVcpz and HIV-1 strains based on full-length sequences. Trees were inferred by the Bayesian method for Gag, Pol, and Env; the Pol protein was separated into two fragments at a recombination breakpoint previously identified in HIV-1 group N (5, 21); the C terminus of Pol was concatenated with downstream Vif sequences. Sequences are color-coded as in Fig. 3. Numbers on internal branches indicate estimated posterior probabilities (only values above 95% are shown). The scale bars represent 0.05 and 0.1 substitutions per site. Arrows indicate branches where cross-species transmissions gave rise to HIV-1 groups M and N.</div> </figcaption> </figure> </div> <!-- Root element of PhotoSwipe. 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Epub 2024 Jun 7.</span> <span class="docsum-journal-citation short-journal-citation">EMBO Rep. 2024.</span> <span class="citation-part">PMID: <span class="docsum-pmid">38849672</span></span> <span class="free-resources spaced-citation-item citation-part">Free PMC article.</span> </div> </div> </li> </ul> <div class="actions-bar"> <a class="show-all-linked-articles" data-href="/?linkname=pubmed_pubmed_citedin&from_uid=16728595" data-ga-category="cited_by" data-ga-action="show_all" > See all "Cited by" articles </a> </div> </div> <div class="references" id="references"> <h2 class="title"> References </h2> <div id='top-references-list' class="references-lists-container"> <div class="refs-list"> <ol id="top-references-list-1" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Peeters M, et al. AIDS. 1989;3:625. - <a class="reference-link" href="/2512955/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="2512955" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Huet T, et al. Nature. 1990;345:356. - <a class="reference-link" href="/2188136/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="2188136" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Groves CP. In: Mammalian Species of the World: A Taxonomic and Geographic Reference. 2. Wilson DE, Reader DM, editors. Smithsonian Institution Press; Washington, DC: 1993. pp. 243–277. </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Sharp PM, Shaw GM, Hahn BH. J Virol. 2005;79:3891. - <a class="reference-link" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC1061584/" ref="linksrc=references_link&ordinalpos=1" data-ga-category="reference" data-ga-action="PMC1061584" > PMC </a> - <a class="reference-link" href="/15767392/" ref="linksrc=references_link&ordinalpos=2" data-ga-category="reference" data-ga-action="15767392" > PubMed </a> </li> </ol> </li> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Gao F, et al. 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class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Disease+Reservoirs%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Disease+Reservoirs%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Disease Reservoirs"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Disease Reservoirs*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Disease+Reservoirs" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Disease Reservoirs*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Disease Reservoirs"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Disease Reservoirs"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Feces / virology" tabindex="0" aria-controls="keyword-actions-mesh-terms-8" aria-expanded="false" data-pinger-ignore> Feces / virology </button><div id="keyword-actions-mesh-terms-8" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Feces / virology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Feces%2Fvirology%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Feces%2Fvirology%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Feces/virology"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Feces / virology"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" 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class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22HIV-1%2Fclassification%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22HIV-1%2Fclassification%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="HIV-1/classification"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="HIV-1 / classification"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=HIV-1" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="HIV-1 / classification"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""HIV-1/classification"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""HIV-1/classification"[MeSH]" href="#"> Add to Search 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keyword Haplotypes"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Haplotypes%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Haplotypes%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Haplotypes"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Haplotypes"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Haplotypes" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Haplotypes"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Haplotypes"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Haplotypes"[MeSH]" href="#"> Add to Search 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class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Molecular+Epidemiology%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Molecular+Epidemiology%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Molecular Epidemiology"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Molecular Epidemiology"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Molecular+Epidemiology" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Molecular Epidemiology"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Molecular Epidemiology"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Molecular Epidemiology"[MeSH]" href="#"> 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dropdown-block-link" href="/?term=%22Pan+troglodytes%2Fvirology%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Pan+troglodytes%2Fvirology%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Pan troglodytes/virology"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Pan troglodytes / virology*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Pan+troglodytes" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Pan troglodytes / virology*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Pan troglodytes/virology"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Pan troglodytes/virology"[MAJR]" href="#"> Add to Search 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data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Simian Immunodeficiency Virus/genetics"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Simian Immunodeficiency Virus / immunology" tabindex="0" aria-controls="keyword-actions-mesh-terms-27" aria-expanded="false" data-pinger-ignore> Simian Immunodeficiency Virus / immunology </button><div id="keyword-actions-mesh-terms-27" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Simian Immunodeficiency Virus / immunology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Simian+Immunodeficiency+Virus%2Fimmunology%22%5BMeSH%5D&sort=date&sort_order=desc" 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</a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Simian Immunodeficiency Virus / isolation & purification" tabindex="0" aria-controls="keyword-actions-mesh-terms-28" aria-expanded="false" data-pinger-ignore> Simian Immunodeficiency Virus / isolation & purification </button><div id="keyword-actions-mesh-terms-28" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Simian Immunodeficiency Virus / isolation & purification"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Simian+Immunodeficiency+Virus%2Fisolation+and+purification%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Simian+Immunodeficiency+Virus%2Fisolation+and+purification%22%5BMeSH%5D&sort=date&sort_order=desc" 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id="substances" class="substances keywords-section"> <h2 class="title"> Substances </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Antibodies, Viral" tabindex="0" aria-controls="keyword-actions-substances-0" aria-expanded="false" data-pinger-ignore> Antibodies, Viral </button><div id="keyword-actions-substances-0" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Antibodies, Viral"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Antibodies%2C+Viral%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Antibodies%2C+Viral%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Antibodies, Viral"[nm]" data-ga-category="search" 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id="keyword-actions-substances-1" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword DNA, Mitochondrial"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22DNA%2C+Mitochondrial%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22DNA%2C+Mitochondrial%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="DNA, Mitochondrial"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="DNA, Mitochondrial"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22DNA%2C+Mitochondrial%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="DNA, Mitochondrial"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""DNA, Mitochondrial"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""DNA, Mitochondrial"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword HIV Antibodies" tabindex="0" aria-controls="keyword-actions-substances-2" aria-expanded="false" data-pinger-ignore> HIV Antibodies </button><div id="keyword-actions-substances-2" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword HIV Antibodies"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22HIV+Antibodies%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22HIV+Antibodies%22%5Bnm%5D&sort=date&sort_order=desc" 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