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Interoceptive inference and prediction in food-related disorders
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Thaiss</a></span></li> </ol> <ol class="affiliation-list"> <li class="aff"><a id="aff-1" name="aff-1"></a><address>Microbiology Department, Institute for Immunology, Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA </address> </li> </ol> <ol class="corresp-list"> <li class="corresp" id="corresp-1">Corresponding author: <span class="em-link"><span class="em-addr">thaiss{at}pennmedicine.upenn.edu</span></span></li> </ol> </div> <div class="section abstract" id="abstract-2"> <h2>Abstract</h2> <p id="p-3">The brain's capacity to predict and anticipate changes in internal and external environments is fundamental to initiating efficient adaptive responses, behaviors, and reflexes that minimize disruptions to physiology. In the context of feeding control, the brain predicts and anticipates responses to the consumption of dietary substances, thus driving adaptive behaviors in the form of food choices, physiological preparation for meals, and engagement of defensive mechanisms. Here, we provide an integrative perspective on the multisensory computation between exteroceptive and interoceptive cues that guides feeding strategy and may result in food-related disorders. </p> </div> <h3 class="kwd-header">Keywords</h3> <ul class="kwd-group"> <li class="kwd"><span><a class="kwd-search" href="/search?fulltext=brain%E2%80%93body&sortspec=date&submit=Submit&andorexactfulltext=phrase">brain鈥揵ody</a></span></li> <li class="kwd"><span><a class="kwd-search" href="/search?fulltext=physiology&sortspec=date&submit=Submit&andorexactfulltext=phrase">physiology</a></span></li> <li class="kwd"><span><a class="kwd-search" href="/search?fulltext=symposium&sortspec=date&submit=Submit&andorexactfulltext=phrase">symposium</a></span></li> </ul> <div class="section fn-group" id="fn-group-1"> <h2>Footnotes</h2> <ul> <li class="fn" id="fn-1"> <p id="p-18">Article published online ahead of print. Article and publication date are online at <a href="http://www.genesdev.org/cgi/doi/10.1101/gad.352301.124">http://www.genesdev.org/cgi/doi/10.1101/gad.352301.124</a>. </p> </li> <li class="fn" id="fn-2"> <p id="p-19">Freely available online through the <em>Genes & Development</em> Open Access option. </p> </li> </ul> </div> <ul class="copyright-statement"> <li class="fn" id="copyright-statement-1"><a href="/site/misc/terms.xhtml">漏 2024 Subramanian and Thaiss; Published by Cold Spring Harbor Laboratory Press</a></li> </ul> <div class="license" id="license-1"> <p id="p-1">This article, published in <em>Genes & Development</em>, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at <a href="http://creativecommons.org/licenses/by-nc/4.0/" rel="license">http://creativecommons.org/licenses/by-nc/4.0/</a>. </p> </div><span class="highwire-journal-article-marker-end"></span></div> <div class="social-bookmarking"> <ul 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