CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width, initial-scale=1"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>Sujoy Khan - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "profiles/works", 'action': "summary", 'controller_action': 'profiles/works#summary', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="8HRQOGprjN1iqr4b77J-fBFs8OffauEFGGrkX6H8juexn_ZjW9Pt4XdGA_9yChSct2MkvJPjgyJ57YWVwyOqng" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/wow-3d36c19b4875b226bfed0fcba1dcea3f2fe61148383d97c0465c016b8c969290.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/social/home-79e78ce59bef0a338eb6540ec3d93b4a7952115b56c57f1760943128f4544d42.css" /><script type="application/ld+json">{"@context":"https://schema.org","@type":"ProfilePage","mainEntity":{"@context":"https://schema.org","@type":"Person","name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"dateCreated":"2015-02-28T20:41:54-08:00","dateModified":"2024-03-23T16:53:06-07:00"}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/heading-95367dc03b794f6737f30123738a886cf53b7a65cdef98a922a98591d60063e3.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-8c9ae4b5c8a2531640c354d92a1f3579c8ff103277ef74913e34c8a76d4e6c00.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-170d1319f0e354621e81ca17054bb147da2856ec0702fe440a99af314a6338c5.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-2b6f90dbd75f5941bc38f4ad716615f3ac449e7398313bb3bc225fba451cd9fa.css" /> <meta name="author" content="sujoy khan" /> <meta name="description" content="Sujoy Khan: 22 Followers, 29 Following, 149 Research papers. Research interests: Mild Cognitive Impairment, Quantitative methodology, and Alzheimer's Disease." /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'works'; var $action_name = "summary"; var $rails_env = 'production'; var $app_rev = '1e60a92a442ff83025cbe4f252857ee7c49c0bbe'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":14008,"monthly_visitors":"108 million","monthly_visitor_count":108476212,"monthly_visitor_count_in_millions":108,"user_count":283759172,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1740566500000); window.Aedu.timeDifference = new Date().getTime() - 1740566500000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link rel="preload" href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" as="style" onload="this.rel='stylesheet'"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-1eb081e01ca8bc0c1b1d866df79d9eb4dd2c484e4beecf76e79a7806c72fee08.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-63c3b84e278fb86e50772ccc2ac0281a0f74ac7e2f88741ecad58131583d4c47.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-85b27a68dc793256271cea8ce6f178025923f9e7e3c7450780e59eacecf59a75.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://independent.academia.edu/SujoyKhan" /> </head>   <body class='c-profiles/works a-summary logged_out'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/hc/en-us"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <script src="//a.academia-assets.com/assets/webpack_bundles/profile.wjs-bundle-4a9f418052ec7a403e004849742322653b010f552f60e892779ac5b03c4cc162.js" defer="defer"></script><script>$viewedUser = Aedu.User.set_viewed( {"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan","photo":"https://0.academia-photos.com/26980189/7570641/8499316/s65_sujoy.khan.jpg","has_photo":true,"is_analytics_public":false,"interests":[{"id":8971,"name":"Mild Cognitive Impairment","url":"https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment"},{"id":12621,"name":"Quantitative methodology","url":"https://www.academia.edu/Documents/in/Quantitative_methodology"},{"id":3776,"name":"Alzheimer's Disease","url":"https://www.academia.edu/Documents/in/Alzheimers_Disease"},{"id":3662,"name":"Dementia","url":"https://www.academia.edu/Documents/in/Dementia"},{"id":6553,"name":"History of Public Health","url":"https://www.academia.edu/Documents/in/History_of_Public_Health"}]} ); if ($a.is_logged_in() && $viewedUser.is_current_user()) { $('body').addClass('profile-viewed-by-owner'); } $socialProfiles = [{"id":10234289,"link":"http://drsujoykhan.webs.com","name":"Homepage","link_domain":"drsujoykhan.webs.com","icon":"//www.google.com/s2/u/0/favicons?domain=drsujoykhan.webs.com"}]</script><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/SujoyKhan","location":"/SujoyKhan","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/SujoyKhan","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="ProfileCheckPaperUpdate" data-props="{}" data-trace="false" data-dom-id="ProfileCheckPaperUpdate-react-component-29b06985-6aec-4a6c-bf74-e352be03387e"></div> <div id="ProfileCheckPaperUpdate-react-component-29b06985-6aec-4a6c-bf74-e352be03387e"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" alt="Sujoy Khan" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/26980189/7570641/8499316/s200_sujoy.khan.jpg" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Sujoy Khan</h1><div class="affiliations-container fake-truncate js-profile-affiliations"></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Sujoy" data-follow-user-id="26980189" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="26980189"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">22</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">29</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">4</p></div></a><div class="js-mentions-count-container" style="display: none;"><a href="/SujoyKhan/mentions"><div class="stat-container"><p class="label">Mentions</p><p class="data"></p></div></a></div><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="user-bio-container"><div class="profile-bio fake-truncate js-profile-about" style="margin: 0px;"><b>Address: </b>Kolkata, West Bengal, India<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="suggested-academics-container"><div class="suggested-academics--header"><p class="ds2-5-body-md-bold">Related Authors</p></div><ul class="suggested-user-card-list"><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/RizalArdiansyah31"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/RizalArdiansyah31">Rizal Ardiansyah</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://uniroma1.academia.edu/CaterinaAnania"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://uniroma1.academia.edu/CaterinaAnania">Caterina Anania</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Università degli Studi "La Sapienza" di Roma</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/AnnaPelkonen"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/AnnaPelkonen">Anna Pelkonen</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/MikaelKuitunen"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/MikaelKuitunen">Mikael Kuitunen</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://uq.academia.edu/FrancesConnor"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://uq.academia.edu/FrancesConnor">Frances Connor</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">The University of Queensland, Australia</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/MARINAGORDO"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/MARINAGORDO">MARINA GORDO</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/AlessandraGiuliano2"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/AlessandraGiuliano2">Alessandra Giuliano</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://pte.academia.edu/DominikaLendvaiEmmert"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://pte.academia.edu/DominikaLendvaiEmmert">Dominika Lendvai-Emmert</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of Pecs</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/SelimSancak"><img class="profile-avatar u-positionAbsolute" alt="Selim Sancak" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/23121082/9945095/11089344/s200_selim.sancak.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/SelimSancak">Selim Sancak</a></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://independent.academia.edu/mALIede"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://independent.academia.edu/mALIede">montaha AL-Iede</a></div></div></ul></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="26980189" href="https://www.academia.edu/Documents/in/Mild_Cognitive_Impairment"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/SujoyKhan","location":"/SujoyKhan","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/SujoyKhan","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Mild Cognitive Impairment"]}" data-trace="false" data-dom-id="Pill-react-component-3a18ba8a-bb1e-4825-a242-0970c963fdef"></div> <div id="Pill-react-component-3a18ba8a-bb1e-4825-a242-0970c963fdef"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="26980189" href="https://www.academia.edu/Documents/in/Quantitative_methodology"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Quantitative methodology"]}" data-trace="false" data-dom-id="Pill-react-component-1f17e4da-2e10-4286-a100-57395cf50afe"></div> <div id="Pill-react-component-1f17e4da-2e10-4286-a100-57395cf50afe"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="26980189" href="https://www.academia.edu/Documents/in/Alzheimers_Disease"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Alzheimer's Disease"]}" data-trace="false" data-dom-id="Pill-react-component-5c4213a9-e733-4355-a664-a4cf2c966cce"></div> <div id="Pill-react-component-5c4213a9-e733-4355-a664-a4cf2c966cce"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="26980189" href="https://www.academia.edu/Documents/in/Dementia"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Dementia"]}" data-trace="false" data-dom-id="Pill-react-component-bcc75391-ec25-4ebe-a4b4-15ba04a2a8a7"></div> <div id="Pill-react-component-bcc75391-ec25-4ebe-a4b4-15ba04a2a8a7"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="26980189" href="https://www.academia.edu/Documents/in/History_of_Public_Health"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["History of Public Health"]}" data-trace="false" data-dom-id="Pill-react-component-2b2680ad-8949-4945-a3e0-4c509ba708b3"></div> <div id="Pill-react-component-2b2680ad-8949-4945-a3e0-4c509ba708b3"></div> </a></div></div><div class="external-links-container"><ul class="profile-links new-profile js-UserInfo-social"><li class="profile-profiles js-social-profiles-container"><i class="fa fa-spin fa-spinner"></i></li></ul></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Sujoy Khan</h3></div><div class="js-work-strip profile--work_container" data-work-id="116607642"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/116607642/Testing_for_Fecal_Calprotectin_in_Food_Protein_Induced_Enterocolitis_Syndrome"><img alt="Research paper thumbnail of Testing for Fecal Calprotectin in Food Protein–Induced Enterocolitis Syndrome" class="work-thumbnail" src="https://attachments.academia-assets.com/112690262/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/116607642/Testing_for_Fecal_Calprotectin_in_Food_Protein_Induced_Enterocolitis_Syndrome">Testing for Fecal Calprotectin in Food Protein–Induced Enterocolitis Syndrome</a></div><div class="wp-workCard_item"><span>Journal of Investigational Allergology and Clinical Immunology</span><span>, Aug 1, 2018</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fa6ffd38632568290dd1a767b1e7c52b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112690262,"asset_id":116607642,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112690262/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607642"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607642"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607642; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607642]").text(description); $(".js-view-count[data-work-id=116607642]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607642; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607642']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fa6ffd38632568290dd1a767b1e7c52b" } } $('.js-work-strip[data-work-id=116607642]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607642,"title":"Testing for Fecal Calprotectin in Food Protein–Induced Enterocolitis Syndrome","internal_url":"https://www.academia.edu/116607642/Testing_for_Fecal_Calprotectin_in_Food_Protein_Induced_Enterocolitis_Syndrome","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":112690262,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112690262/thumbnails/1.jpg","file_name":"d1a4a0065a7e676ac09796c13878ac562e4f.pdf","download_url":"https://www.academia.edu/attachments/112690262/download_file","bulk_download_file_name":"Testing_for_Fecal_Calprotectin_in_Food_P.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112690262/d1a4a0065a7e676ac09796c13878ac562e4f-libre.pdf?1711241804=\u0026response-content-disposition=attachment%3B+filename%3DTesting_for_Fecal_Calprotectin_in_Food_P.pdf\u0026Expires=1740570099\u0026Signature=a00mCanL6fyA~6K7QkUMamTzIQBLq0~1MVo-mcByxVMUgry900r3wGeCOMzsYtbkNpkMpJwu8EZS1e9gNevMn4u8GGuez6NXTmjvyy8tkW8n7Okj5rWBJGtE11dQlvwnIt3jNtcnOUFpOkOqnRPlXKUyRl7459piiJS3A9z5OyUYMv30~mweJz15lip38WlYN~mjIDWmN3JseyeLQka7dnf1H5SGB2Zk2CE1ojir2ZSM4Zc0qn20MGmzM7EC0Q85Fi8Y9uIQw4c7Hi81Y-d~aoF~ghoBwJVAmYnoRzezls0VGeAT1lNU1LteQ08FAQk9Zv5fkZsdKG28ST43KY-EHw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607640"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/116607640/JAK_Inhibition_as_a_Therapeutic_Strategy_for_IgG4_RD"><img alt="Research paper thumbnail of JAK Inhibition as a Therapeutic Strategy for IgG4-RD" class="work-thumbnail" src="https://attachments.academia-assets.com/112690260/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/116607640/JAK_Inhibition_as_a_Therapeutic_Strategy_for_IgG4_RD">JAK Inhibition as a Therapeutic Strategy for IgG4-RD</a></div><div class="wp-workCard_item"><span>Journal of Investigational Allergology and Clinical Immunology</span><span>, Jun 22, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The review by Carballo et al [1] provides an excellent summary of the varied clinical presentatio...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The review by Carballo et al [1] provides an excellent summary of the varied clinical presentations of IgG4-related disease (IgG4-RD), highlighting the role of clinicians and insisting on a detailed pathological description of affected organs with IgG4-stained plasmablasts infiltrating tissues to arrive at a diagnosis. However, the cytokine environment and what makes this "nonpathogenic" IgG isotype cause irreversible end-organ damage remains unknown. As the authors rightly discuss, both autoimmune and allergic aspects of IgG4-RD are involved. In addition to the general approach to managing the diverse clinical presentations of this disease, we would like to discuss the cytokine signalling involved in IgG4-RD in more detail and suggest Janus-associated kinase (JAK) inhibition as alternative therapeutic strategy to manage this condition. Autoimmunity implies a perpetual cycle that is initiated by a cell-damaging event that modifies self-antigens. Tissueresident antigen-presenting cells increase MHC class II expression and present modified antigens to T cells, and the unique cytokine environment switches CD4 + T H 2 T-cell differentiation, which in turn drives an adaptive immune response towards IgG4 plasma cell differentiation and, eventually, end-organ damage with fibrosis (Figure). The pathogenic role of IgG4 was shown to involve passive transfer of antibodies from patients with IgG4-RD causing pancreatic and salivary gland injury in neonatal Balb/c mice [2]. Distinct glycosylation changes on IgG4 with increased G0 and F1 glycans in patients with IgG4-RD and hypocomplementemia suggest activation of the lectin pathway on phagocytes to induce chronic inflammation [3,4]. Interestingly, in the pancreatic ovalbumin mouse model</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7fc82e8c2a4da60ba83dec7ed42821cf" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112690260,"asset_id":116607640,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112690260/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607640"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607640"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607640; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607640]").text(description); $(".js-view-count[data-work-id=116607640]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607640; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607640']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7fc82e8c2a4da60ba83dec7ed42821cf" } } $('.js-work-strip[data-work-id=116607640]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607640,"title":"JAK Inhibition as a Therapeutic Strategy for IgG4-RD","internal_url":"https://www.academia.edu/116607640/JAK_Inhibition_as_a_Therapeutic_Strategy_for_IgG4_RD","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":112690260,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112690260/thumbnails/1.jpg","file_name":"vol31issue3_7.pdf","download_url":"https://www.academia.edu/attachments/112690260/download_file","bulk_download_file_name":"JAK_Inhibition_as_a_Therapeutic_Strategy.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112690260/vol31issue3_7-libre.pdf?1711241802=\u0026response-content-disposition=attachment%3B+filename%3DJAK_Inhibition_as_a_Therapeutic_Strategy.pdf\u0026Expires=1740570099\u0026Signature=ejlRFxAGd4zGYaVQK0DtPiPUFQ4KKb17vaXJBOW62-x75hYMoXX8nbyS51jrlbMRZffzFHii2LZBKjDe92ztldaw6btPOqhXiYJnKPi9XDjd28R59pcyrf-SI91v2FdJBC0Qa~YP4g8~sDFkMoR0quZXtmGUbxYyOXDa6ngI-JsaerSMl9RYbyccrBvp9xmEsggY~QbtW-aSuO4~~H6sOWWGVwa8dKKh9sexgoS8dWAXbGSN1Z26fF2vQGiQgtM5bCMjbbm5KoNviQpydaziWrKk7MOftqEZsW2krfrOJBPMagd5u11Gs2XICdekByJNnVc93nHtuWSZSqyAJNoVTg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607637"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/116607637/Routine_testing_not_beneficial_in_evaluation_of_patients_with_chronic_spontaneous_urticaria"><img alt="Research paper thumbnail of Routine testing not beneficial in evaluation of patients with chronic spontaneous urticaria" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/116607637/Routine_testing_not_beneficial_in_evaluation_of_patients_with_chronic_spontaneous_urticaria">Routine testing not beneficial in evaluation of patients with chronic spontaneous urticaria</a></div><div class="wp-workCard_item"><span>Indian Dermatology Online Journal</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">© 2020 Indian Dermatology Online Journal | Published by Wolters Kluwer Medknow Dear Editor, We re...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">© 2020 Indian Dermatology Online Journal | Published by Wolters Kluwer Medknow Dear Editor, We read with interest the paper by Shailaja Chauhan and colleagues where they found that elevated plasma levels of D‐dimer in patients with chronic spontaneous urticaria (CSU) may influence treatment options,[1] but the tests did not make any difference in the overall management of patients. We present our experience with a quality improvement project, which determined the usefulness of routine testing in CSU. The British Society of Allergy &amp; Clinical Immunology guidelines[2] were used as standards [Table 1] and was approved by the Clinical Audit and Effectiveness Team of Hull University Teaching Hospitals NHS Trust. Patients with CSU were identified from clinic letters. The first phase (Plan, Do, Study Act Cycle 1) reviewed 169 new consultations for 7 months between September 2018 and March 2019, with a follow‐ up phase (PDSA Cycle 2) of 190 new consultations for 4 months between September 2019 and December 2019. Performances with regards to standards are shown in Table 1.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607637"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607637"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607637; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607637]").text(description); $(".js-view-count[data-work-id=116607637]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607637; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607637']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=116607637]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607637,"title":"Routine testing not beneficial in evaluation of patients with chronic spontaneous urticaria","internal_url":"https://www.academia.edu/116607637/Routine_testing_not_beneficial_in_evaluation_of_patients_with_chronic_spontaneous_urticaria","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607635"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/116607635/JAK_Inhibition_with_Methotrexate_as_Treatment_for_COVID_19_Is_a_Double_Edged_Sword"><img alt="Research paper thumbnail of JAK Inhibition with Methotrexate as Treatment for COVID-19 Is a Double-Edged Sword" class="work-thumbnail" src="https://attachments.academia-assets.com/112690249/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/116607635/JAK_Inhibition_with_Methotrexate_as_Treatment_for_COVID_19_Is_a_Double_Edged_Sword">JAK Inhibition with Methotrexate as Treatment for COVID-19 Is a Double-Edged Sword</a></div><div class="wp-workCard_item"><span>International Archives of Allergy and Immunology</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8491ad0275260b328153a5eab22ed1eb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112690249,"asset_id":116607635,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112690249/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607635"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607635"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607635; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607635]").text(description); $(".js-view-count[data-work-id=116607635]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607635; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607635']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8491ad0275260b328153a5eab22ed1eb" } } $('.js-work-strip[data-work-id=116607635]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607635,"title":"JAK Inhibition with Methotrexate as Treatment for COVID-19 Is a Double-Edged Sword","internal_url":"https://www.academia.edu/116607635/JAK_Inhibition_with_Methotrexate_as_Treatment_for_COVID_19_Is_a_Double_Edged_Sword","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":112690249,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112690249/thumbnails/1.jpg","file_name":"000508750.pdf","download_url":"https://www.academia.edu/attachments/112690249/download_file","bulk_download_file_name":"JAK_Inhibition_with_Methotrexate_as_Trea.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112690249/000508750-libre.pdf?1711241803=\u0026response-content-disposition=attachment%3B+filename%3DJAK_Inhibition_with_Methotrexate_as_Trea.pdf\u0026Expires=1740570099\u0026Signature=GNvbgqBsJFy5lgP5n2P4IOZwjfapYpJHithxN9of--ur6bwLeIN6~Lwj5Odxrz0L5FL5RyzOIemUVc1y0cE36zfUQ9GzVqFE8Sr2LFG-lxmFPkLyJvPyUFLlxor~ZqNlyTytHSzKyZDdkVcOmb-gC2P3h6v9gFVxfPVEGQLRM2HPmhO~~nxRWLMJ0ZvfJTCMzq8RlmKCjRihDzmrteIadnbCY6W9DpvN3EZTPisS6ibtXMVDG-N7ddWPwDKk4m8N5DliCbGBKIL61b6nurceRkoVFGlnIILnnfB3D-LauO72QaArZoHDe-y0huy7r6xNDljeHuXFhjkHNsUc3Pkjpw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":112690250,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112690250/thumbnails/1.jpg","file_name":"000508750.pdf","download_url":"https://www.academia.edu/attachments/112690250/download_file","bulk_download_file_name":"JAK_Inhibition_with_Methotrexate_as_Trea.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112690250/000508750-libre.pdf?1711241803=\u0026response-content-disposition=attachment%3B+filename%3DJAK_Inhibition_with_Methotrexate_as_Trea.pdf\u0026Expires=1740570099\u0026Signature=LT~XV4deLfIzUY4GdlKSp0a3ahrN8iyxz1QlnecKi8zUeEsrXfutIliwyaARHNxZEtL0Ve8IttxoiuWg62Ds3SBFiuAFuCTadrtsb8EkUG-3Pppy~pNuzlA8OVY-m5VplmJeRUnMvA50NGFwgPM3FvdLk9L1tZNLuZVleItNZURj9g9XXE0-azc~nxzqBk-1EKaciAEJokgms7LwgmjHikJL0QglGJbk7zozSjIJBT85YXOM3KOaERPg~1dIhvmd1jAwKJlixbpvb2k7uiAL7j-f40vHAzOlEQQlRl2jv85MGC9vnXTZoLRIpCZw8lwIqVhccUupRM2XMVopFEs5VA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607634"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/116607634/Interstitial_lung_disease_in_common_variable_immunodeficiency"><img alt="Research paper thumbnail of Interstitial lung disease in common variable immunodeficiency" class="work-thumbnail" src="https://attachments.academia-assets.com/112690261/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/116607634/Interstitial_lung_disease_in_common_variable_immunodeficiency">Interstitial lung disease in common variable immunodeficiency</a></div><div class="wp-workCard_item"><span>British journal of hospital medicine</span><span>, Dec 20, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Drug hypersensitivity reactions (DHR) are frequently encountered in clinical practice, and often ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Drug hypersensitivity reactions (DHR) are frequently encountered in clinical practice, and often result in significant morbidity and mortality. Diagnosis of DHR is based upon clinical signs, symptomatology and biochemical parameters, and is frequently complicated by factors including polypharmacy and difficulty excluding conditions mimicking DHR. Currently available laboratory assays employed in the work-up of DHR include evaluation of lymphocytes, basophils and other cell types in peripheral blood specimens after ex-vivo stimulation with the culprit drug in the convalescent phase, several weeks after the initial reaction. There are no robust tests available for diagnosing DHR at the time of the reaction. The ability to diagnose and differentiate between various reaction types during the acute phase would facilitate early identification and specific management of affected patients. Up-regulation of several cell surface activation markers have been described in the context of Type 4 DHR, including CD69 which becomes up-regulated in various cell types, increased expression of CD40L, HLA-DR and CD25 on T cells, and up-regulation of CD107a and cytoplasmic perforin and granzyme in NK and cytotoxic T cells. 1 We present a case-based discussion of patterns of immune activation in the peripheral blood of patients presenting with acute DHR, and describe the differential up-regulation of various cell surface and cytoplasmic markers in different DHR sub-types. Reference 1. Porebski G, Gschwend-Zawodniak A, Pichler WJ. In vitro diagnosis of T cell-mediated drug allergy. Clin Exp Allergy 2011; 41: 461-70.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b90b376d71075cbe32c7531289ba9267" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112690261,"asset_id":116607634,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112690261/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607634"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607634"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607634; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607634]").text(description); $(".js-view-count[data-work-id=116607634]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607634; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607634']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b90b376d71075cbe32c7531289ba9267" } } $('.js-work-strip[data-work-id=116607634]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607634,"title":"Interstitial lung disease in common variable immunodeficiency","internal_url":"https://www.academia.edu/116607634/Interstitial_lung_disease_in_common_variable_immunodeficiency","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":112690261,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112690261/thumbnails/1.jpg","file_name":"01.pat.0000461429.97369.e720240323-1-ebykd9.pdf","download_url":"https://www.academia.edu/attachments/112690261/download_file","bulk_download_file_name":"Interstitial_lung_disease_in_common_vari.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112690261/01.pat.0000461429.97369.e720240323-1-ebykd9-libre.pdf?1711241802=\u0026response-content-disposition=attachment%3B+filename%3DInterstitial_lung_disease_in_common_vari.pdf\u0026Expires=1740570099\u0026Signature=TctA53LEcwsJT0xY8iDSmnke0RoCREs5yjrqk44cP7U82BaklXLBN~TBk5csGO18vv4h3ifL~I6~Dyiz6WORfNvAgxoXw4W7Q5liuWiZYpvpfFbD6UqeAyK7U4zd58eEjiYZMVflt-aL24Gz2mAc1QW0cN~oLQ29y~lYSITbWnp2T1ppFYCL-9sexV1YJQVcO6AKbp~HwOCOFOboXN~RvgoeKFf8B1pX7XxB29s3xL9cEbwB3fyBFMDtd483WHs8CF0XWiE80gQA-g3AIM4p2c~l7zGzlA3nUtxpByg3iqjxzinhXg~z6h7DfagNJaRwNoLNUGv2fJixcZCGK~P9SQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607631"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/116607631/Psoriasis"><img alt="Research paper thumbnail of Psoriasis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/116607631/Psoriasis">Psoriasis</a></div><div class="wp-workCard_item"><span>The New England Journal of Medicine</span><span>, Aug 25, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607631"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607631"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607631; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607631]").text(description); $(".js-view-count[data-work-id=116607631]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607631; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607631']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=116607631]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607631,"title":"Psoriasis","internal_url":"https://www.academia.edu/116607631/Psoriasis","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607630"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/116607630/House_dust_mite_allergy_is_a_major_cause_for_respiratory_symptoms_and_sleep_disorders_in_young_children"><img alt="Research paper thumbnail of House dust mite allergy is a major cause for respiratory symptoms and sleep disorders in young children" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/116607630/House_dust_mite_allergy_is_a_major_cause_for_respiratory_symptoms_and_sleep_disorders_in_young_children">House dust mite allergy is a major cause for respiratory symptoms and sleep disorders in young children</a></div><div class="wp-workCard_item"><span>Lung India</span><span>, 2022</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607630"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607630"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607630; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607630]").text(description); $(".js-view-count[data-work-id=116607630]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607630; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607630']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=116607630]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607630,"title":"House dust mite allergy is a major cause for respiratory symptoms and sleep disorders in young children","internal_url":"https://www.academia.edu/116607630/House_dust_mite_allergy_is_a_major_cause_for_respiratory_symptoms_and_sleep_disorders_in_young_children","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607629"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/116607629/Managing_patients_with_Th2_severe_refractory_asthma_with_bronchial_thermoplasty"><img alt="Research paper thumbnail of Managing patients with Th2 severe refractory asthma with bronchial thermoplasty" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/116607629/Managing_patients_with_Th2_severe_refractory_asthma_with_bronchial_thermoplasty">Managing patients with Th2 severe refractory asthma with bronchial thermoplasty</a></div><div class="wp-workCard_item"><span>Journal of precision respiratory medicine</span><span>, Oct 1, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607629"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607629"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607629; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607629]").text(description); $(".js-view-count[data-work-id=116607629]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607629; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607629']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=116607629]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607629,"title":"Managing patients with Th2 severe refractory asthma with bronchial thermoplasty","internal_url":"https://www.academia.edu/116607629/Managing_patients_with_Th2_severe_refractory_asthma_with_bronchial_thermoplasty","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607628"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/116607628/Nimesulide_and_adverse_drug_reactions_Time_for_a_database"><img alt="Research paper thumbnail of Nimesulide and adverse drug reactions: Time for a database" class="work-thumbnail" src="https://attachments.academia-assets.com/112695930/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/116607628/Nimesulide_and_adverse_drug_reactions_Time_for_a_database">Nimesulide and adverse drug reactions: Time for a database</a></div><div class="wp-workCard_item"><span>Journal of Postgraduate Medicine</span><span>, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="56a069ccdec4ca67a7dd42aaa7fad1f1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112695930,"asset_id":116607628,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112695930/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607628"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607628"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607628; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607628]").text(description); $(".js-view-count[data-work-id=116607628]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607628; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607628']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "56a069ccdec4ca67a7dd42aaa7fad1f1" } } $('.js-work-strip[data-work-id=116607628]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607628,"title":"Nimesulide and adverse drug reactions: Time for a database","internal_url":"https://www.academia.edu/116607628/Nimesulide_and_adverse_drug_reactions_Time_for_a_database","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":112695930,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112695930/thumbnails/1.jpg","file_name":"jp08086.pdf","download_url":"https://www.academia.edu/attachments/112695930/download_file","bulk_download_file_name":"Nimesulide_and_adverse_drug_reactions_Ti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112695930/jp08086-libre.pdf?1711265145=\u0026response-content-disposition=attachment%3B+filename%3DNimesulide_and_adverse_drug_reactions_Ti.pdf\u0026Expires=1740570099\u0026Signature=CA-U9nNWmzB7TvIyPoVayTSwcVgsnIxxZfRSniaOylEqLSIJs0XjiV2~XBRmuossEKWPG8l7aQpBnKAFlcqq2oCfa9H3bFO3i3y3BlX0jpNm6C3aOzEMOLV8QBzIrTDSLM7qQo-uZUAcYOEVT7oH-H4moVpLmXvEDhcSyIkGhD6~U4MLIGqrSMIZrqAWyqWm5dqZKZhHQYo5oWisVOCQqRGmdqSGYt1H7dRkyxSMJ1MxQf7D8GbgGnEBO5tDCvO~10dUi6MEqJdfFOBtwvP9T6g1LYNkkIkQieHHMyHuyJ7ddFoE7j8I7O1y1CW0GEneaoLE2bR7QdKai4GBGDxIHg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607627"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/116607627/Celiac_Disease_in_Children_%C3%A2_A_Profile_from_a_Predominantly_Rice_EatingPopulation"><img alt="Research paper thumbnail of Celiac Disease in Children â A Profile from a Predominantly Rice EatingPopulation" class="work-thumbnail" src="https://attachments.academia-assets.com/112690259/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/116607627/Celiac_Disease_in_Children_%C3%A2_A_Profile_from_a_Predominantly_Rice_EatingPopulation">Celiac Disease in Children â A Profile from a Predominantly Rice EatingPopulation</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">India had entered into the global scenario of celiac disease with Northern India being the celiac...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">India had entered into the global scenario of celiac disease with Northern India being the celiac belt. But prevalence studies are lacking from the Eastern part of India.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1070dae390dae7414ebebad1710dda80" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112690259,"asset_id":116607627,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112690259/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607627"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607627"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607627; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607627]").text(description); $(".js-view-count[data-work-id=116607627]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607627; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607627']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1070dae390dae7414ebebad1710dda80" } } $('.js-work-strip[data-work-id=116607627]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607627,"title":"Celiac Disease in Children â A Profile from a Predominantly Rice EatingPopulation","internal_url":"https://www.academia.edu/116607627/Celiac_Disease_in_Children_%C3%A2_A_Profile_from_a_Predominantly_Rice_EatingPopulation","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":112690259,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112690259/thumbnails/1.jpg","file_name":"celiac-disease-in-children--a-profile-from-a-predominantly-rice-eatingpopulation.pdf","download_url":"https://www.academia.edu/attachments/112690259/download_file","bulk_download_file_name":"Celiac_Disease_in_Children_a_A_Profile_f.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112690259/celiac-disease-in-children--a-profile-from-a-predominantly-rice-eatingpopulation-libre.pdf?1711241804=\u0026response-content-disposition=attachment%3B+filename%3DCeliac_Disease_in_Children_a_A_Profile_f.pdf\u0026Expires=1740570099\u0026Signature=cgvFXJtNGZ2yDG2JKHAJXoui08mEort3UWjxHqRhWuxM~W1Atd0lEAouMw2eg7OMABI7jQuN-yCdgCd7eh46qBZwuUFTyFUoGHRzxsRIF3a9SzsPM6lzgXt4S6y1wTzGqOFTXkSa6scLwLhiNQp2qBNj3BdnE2LVwhxNUGeY9AqfWJ7uk88aTvonUnKXG84vNW9u3s6dyRqvgS1cXYfaJLkVro5XRU4so0bIDKG4yJMDpPAumwMRKoPGUF07L~1GBRLpozf7umuPkqAOjIVexCaW82Bv810Re3T4qFhNkUKtImSI-SYL-No9~oinLEiToaX6ysbx9KPU1j~BAqTIAg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607626"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/116607626/Evaluating_sensitization_patterns_on_ImmunoCAP_detected_polysensitized_patients_with_microarray_based_multiplex_assay_ISAC_"><img alt="Research paper thumbnail of Evaluating sensitization patterns on ImmunoCAP-detected polysensitized patients with microarray-based multiplex assay (ISAC)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/116607626/Evaluating_sensitization_patterns_on_ImmunoCAP_detected_polysensitized_patients_with_microarray_based_multiplex_assay_ISAC_">Evaluating sensitization patterns on ImmunoCAP-detected polysensitized patients with microarray-based multiplex assay (ISAC)</a></div><div class="wp-workCard_item"><span>Journal of Allergy and Clinical Immunology</span><span>, 2021</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607626"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607626"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607626; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607626]").text(description); $(".js-view-count[data-work-id=116607626]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607626; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607626']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=116607626]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607626,"title":"Evaluating sensitization patterns on ImmunoCAP-detected polysensitized patients with microarray-based multiplex assay (ISAC)","internal_url":"https://www.academia.edu/116607626/Evaluating_sensitization_patterns_on_ImmunoCAP_detected_polysensitized_patients_with_microarray_based_multiplex_assay_ISAC_","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607607"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/116607607/Emerging_and_Reemerging_Sexually_Transmitted_Infections"><img alt="Research paper thumbnail of Emerging and Reemerging Sexually Transmitted Infections" class="work-thumbnail" src="https://attachments.academia-assets.com/112690242/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/116607607/Emerging_and_Reemerging_Sexually_Transmitted_Infections">Emerging and Reemerging Sexually Transmitted Infections</a></div><div class="wp-workCard_item"><span>New England Journal of Medicine</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2aa75463e13ac744f9bd70e4317c2f6c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112690242,"asset_id":116607607,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112690242/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607607"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607607"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607607; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607607]").text(description); $(".js-view-count[data-work-id=116607607]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607607; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607607']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2aa75463e13ac744f9bd70e4317c2f6c" } } $('.js-work-strip[data-work-id=116607607]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607607,"title":"Emerging and Reemerging Sexually Transmitted Infections","internal_url":"https://www.academia.edu/116607607/Emerging_and_Reemerging_Sexually_Transmitted_Infections","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":112690242,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112690242/thumbnails/1.jpg","file_name":"emerging-and-reemerging-sexually-transmitted-infections.pdf","download_url":"https://www.academia.edu/attachments/112690242/download_file","bulk_download_file_name":"Emerging_and_Reemerging_Sexually_Transmi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112690242/emerging-and-reemerging-sexually-transmitted-infections-libre.pdf?1711241805=\u0026response-content-disposition=attachment%3B+filename%3DEmerging_and_Reemerging_Sexually_Transmi.pdf\u0026Expires=1740570100\u0026Signature=fwul7GDbyOdeJcaZAdZ0uy82LDLxHJNq~9veSAT0mftaXguEL2bhNyW1iBAK7DKkTuklPTLoQkNpTjFR~LCmNGwz4mQfTATSPaD6Ej5vQ6hRCFCcHbLNS5bdiYb5tFMxAKpiyNWSok4dL9iH5OohK20WaTcowr0NY9TA8sWcQkVqCgUq8-weOldtP5D91FjmY7w8-r2m3mfv2bdTJbYJz0eO4A5inuZBotauj6AoVjUoidcLqt4UBE1H5Ut86afHRnHgevk9UqS7E~oS3ExKnx39i-DWmzmEvQetNya3aVd4nJ6Y0KZGEjrrj0OreTagoUVyMjk7rMpW31cu4s~Ywg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112182814"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112182814/An_updated_perspective_on_immunoglobulin_replacement_in_chronic_lymphocytic_leukaemia_in_the_era_of_targeted_therapies"><img alt="Research paper thumbnail of An updated perspective on immunoglobulin replacement in chronic lymphocytic leukaemia in the era of targeted therapies" class="work-thumbnail" src="https://attachments.academia-assets.com/109491743/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112182814/An_updated_perspective_on_immunoglobulin_replacement_in_chronic_lymphocytic_leukaemia_in_the_era_of_targeted_therapies">An updated perspective on immunoglobulin replacement in chronic lymphocytic leukaemia in the era of targeted therapies</a></div><div class="wp-workCard_item"><span>Frontiers in Oncology</span><span>, Apr 6, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Chronic lymphocytic leukaemia (CLL) is a malignancy of clonally expanded antigen-switched, neopla...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Chronic lymphocytic leukaemia (CLL) is a malignancy of clonally expanded antigen-switched, neoplastic, mature B cells. CLL is characterised by a variable degree of immunosuppression and secondary hypogammaglobulinemia. B-cell depleting therapies have historically been deployed with a proportion of patients becoming resistant to multiple lines of treatment with an associated worsening of immunosuppression and heightened infection risk. Advances in molecular diagnostics and the development of new therapies targeting Bruton's tyrosine kinase and B-cell lymphoma-2 have resulted in novel insights into the cellular mechanisms associated with an increased infection risk and T-cell escape from the complex tumour environment found in CLL. Generally, immunoglobulin replacement therapy with polyvalent human immunoglobulin G (IgG) is indicated in patients with recurrent severe bacterial infections and low IgG levels, but there is no consensus on the threshold IgG level for initiation of such therapy. A proportion of CLL patients have residual IgG production, with preserved quality of the immunoglobulin molecules, and therefore a definition of 'IgG quality' may allow for lower dosing or less frequent treatment with immunoglobulin therapy in such patients. Immunoglobulin therapy can restore innate immunity and in conjunction with CLL targeted therapies may allow T-cell antigen priming, restore T-cell function thereby providing an escape from tumour-associated autoimmunity and the development of an immune-mediated anti-tumour effect. This review aims to discuss the mechanisms by which CLL-targeted therapy may exert a synergistic therapeutic effect with immunoglobulin replacement therapy both in terms of reducing tumour bulk and restoration of immune function. KEYWORDS C L L , h y p o g a m m a g l o b u l i n e m i a , I g r e p l a c e m e n t , i m m u n o m o d u l a t i o n , restoration immunity Frontiers in Oncology frontiersin.org 01</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5f7efd41ed1f2ad53302528109a589c7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109491743,"asset_id":112182814,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109491743/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112182814"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112182814"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112182814; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112182814]").text(description); $(".js-view-count[data-work-id=112182814]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112182814; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112182814']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5f7efd41ed1f2ad53302528109a589c7" } } $('.js-work-strip[data-work-id=112182814]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112182814,"title":"An updated perspective on immunoglobulin replacement in chronic lymphocytic leukaemia in the era of targeted therapies","internal_url":"https://www.academia.edu/112182814/An_updated_perspective_on_immunoglobulin_replacement_in_chronic_lymphocytic_leukaemia_in_the_era_of_targeted_therapies","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":109491743,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109491743/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/109491743/download_file","bulk_download_file_name":"An_updated_perspective_on_immunoglobulin.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109491743/pdf-libre.pdf?1703403032=\u0026response-content-disposition=attachment%3B+filename%3DAn_updated_perspective_on_immunoglobulin.pdf\u0026Expires=1740570100\u0026Signature=Ex6WPm71vtCSHBaZtDTyugUxnky0rTRcJfszQvaDbdT6HIX4c7bTn3nXKVbEz9ghXsSBBh96VQ-faLBmo~vTNmadR1NbNFNFHSwsKdaJOi9eK~a7lVOw7~4TlkClpMFyAhANRTiHbmmcvkQIx0mV5CGYzPIZdqsMJZG7ERkcFKq7HEqB1n8ukva6~Qi4EK1B-hBxswv4jfTIEyUTpoDKKfeD-UUA49mp1gT4ukMcKQjBKmpfzqzkUeeTBWCTTOiix06dKYSm9nw~izbjpkWzT-qfYAOck5DLe-xPuAiGjhUMzS5~F2mTKGCCmiT~NLOkQ3Z0Sy~gF988nK0XyNV9zg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112182813"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/112182813/Immunomodulation_mediated_by_polyclonal_IgG_replacement_in_patients_with_chronic_lymphocytic_leukemia_may_be_important_in_infection_prevention"><img alt="Research paper thumbnail of Immunomodulation mediated by polyclonal IgG replacement in patients with chronic lymphocytic leukemia may be important in infection prevention" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/112182813/Immunomodulation_mediated_by_polyclonal_IgG_replacement_in_patients_with_chronic_lymphocytic_leukemia_may_be_important_in_infection_prevention">Immunomodulation mediated by polyclonal IgG replacement in patients with chronic lymphocytic leukemia may be important in infection prevention</a></div><div class="wp-workCard_item"><span>Hematological Oncology</span><span>, May 2, 2022</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112182813"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112182813"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112182813; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112182813]").text(description); $(".js-view-count[data-work-id=112182813]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112182813; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112182813']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=112182813]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112182813,"title":"Immunomodulation mediated by polyclonal IgG replacement in patients with chronic lymphocytic leukemia may be important in infection prevention","internal_url":"https://www.academia.edu/112182813/Immunomodulation_mediated_by_polyclonal_IgG_replacement_in_patients_with_chronic_lymphocytic_leukemia_may_be_important_in_infection_prevention","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112182812"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112182812/Outcomes_following_SARS_CoV_2_infection_in_patients_with_chronic_liver_disease_An_international_registry_study"><img alt="Research paper thumbnail of Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study" class="work-thumbnail" src="https://attachments.academia-assets.com/109491770/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112182812/Outcomes_following_SARS_CoV_2_infection_in_patients_with_chronic_liver_disease_An_international_registry_study">Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study</a></div><div class="wp-workCard_item"><span>Journal of Hepatology</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background & Aims: Chronic liver disease (CLD) and cirrhosis are associated with immune dysregula...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background & Aims: Chronic liver disease (CLD) and cirrhosis are associated with immune dysregulation, leading to concerns that affected patients may be at risk of adverse outcomes following SARS-CoV-2 infection. We aimed to determine the impact of COVID-19 on patients with pre-existing liver disease, which currently remains ill-defined. Methods: Between 25th March and 8th July 2020, data on 745 patients with CLD and SARS-CoV-2 (including 386 with and 359 without cirrhosis) were collected by 2 international registries and compared to data on non-CLD patients with SARS-CoV-2 from a UK hospital network. Results: Mortality was 32% in patients with cirrhosis compared to 8% in those without (p <0.001). Mortality in patients with cirrhosis increased according to Child-Pugh class (A [19%], B [35%], C [51%]) and the main cause of death was from respiratory failure (71%). After adjusting for baseline characteristics, factors associated with death in the total CLD cohort were age (odds ratio [OR] 1.02; 1.01-1.04), Child-Pugh A (OR 1.90; 1.03-3.52), B (OR 4.14; 2.4-7.65), or C (OR 9.32; 4.80-18.08) cirrhosis and alcohol-related liver disease (OR 1.79; 1.03-3.13). Compared to patients without CLD (n = 620), propensity-score-matched analysis revealed significant increases in mortality in those with Child-Pugh B (+20.0% [8.8%-31.3%]) and C (+38.1% [27.1%-49.2%]) cirrhosis. Acute hepatic decompensation occurred in 46% of patients with cirrhosis, of whom 21% had no respiratory symptoms. Half of those with hepatic decompensation had acute-on-chronic liver failure. Conclusions: In the largest such cohort to date, we demonstrate that baseline liver disease stage and alcohol-related liver disease are independent risk factors for death from COVID-19. These data have important implications for the risk stratification of patients with CLD across the globe during the COVID-19 pandemic. Lay summary: This international registry study demonstrates that patients with cirrhosis are at increased risk of death from COVID-19. Mortality from COVID-19 was particularly high among</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="23e1bf498025f9935266e15f79dfabda" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109491770,"asset_id":112182812,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109491770/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112182812"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112182812"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112182812; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112182812]").text(description); $(".js-view-count[data-work-id=112182812]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112182812; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112182812']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "23e1bf498025f9935266e15f79dfabda" } } $('.js-work-strip[data-work-id=112182812]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112182812,"title":"Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study","internal_url":"https://www.academia.edu/112182812/Outcomes_following_SARS_CoV_2_infection_in_patients_with_chronic_liver_disease_An_international_registry_study","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":109491770,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109491770/thumbnails/1.jpg","file_name":"download_file.pdf","download_url":"https://www.academia.edu/attachments/109491770/download_file","bulk_download_file_name":"Outcomes_following_SARS_CoV_2_infection.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109491770/download_file-libre.pdf?1703411135=\u0026response-content-disposition=attachment%3B+filename%3DOutcomes_following_SARS_CoV_2_infection.pdf\u0026Expires=1740570100\u0026Signature=FIHkb-JZT4BUDcd~EtBIHuhWSmwJDfStOYrrvPRzfyCojNDLaUQPX5ETwO2nW8GgP8B2by9dJ4IBgPhsrT-SKLIJj-iS9DXAh9lBkuexaTeXByq7oBBSpgIY2S81fYq8sA2KLAX9xZ6LwIvPxM3G5l48jeTqvzsjSy82~IeQOwO37EWfS6LwRJIRkQJwmyIw67vhSsuVFbSj39xhcvEyxICh5NF0HgTkBi115MNcMYnA-c3Hla7lIb5K2TXV0aqjqRVeue~-lvoSxNSqM--iste33QgLkFdZepGra~vuMrEZ3~qKJEQRo1IFcDiYXg-C18tQyOld8qYNkcOeqcdelA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112182811"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112182811/Omalizumab_retreatment_rates_in_chronic_spontaneous_urticaria"><img alt="Research paper thumbnail of Omalizumab retreatment rates in chronic spontaneous urticaria" class="work-thumbnail" src="https://attachments.academia-assets.com/109491766/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112182811/Omalizumab_retreatment_rates_in_chronic_spontaneous_urticaria">Omalizumab retreatment rates in chronic spontaneous urticaria</a></div><div class="wp-workCard_item"><span>European Annals of Allergy and Clinical Immunology</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Omalizumab re-treatment rates in chronic spontaneous urticaria The review paper by Tonacci A and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Omalizumab re-treatment rates in chronic spontaneous urticaria The review paper by Tonacci A and colleagues highlights the fact that re-treatment with omalizumab for patients with chronic spontaneous urticaria (CSU) is not unusual, which adds significantly to costs of treatment [1]. Our experience with use of omalizumab in CSU has been similar and treatment responses with re-treatment rates are presented. The study was part of an outcome reporting audit aimed to document (1) efficacy; (2) safety profile; (3) failure rates; and (4) identification of factors relating to efficacy or resistance to omalizumab, and was approved by the Clinical Audit and Effectiveness team of the Hull University Teaching Hospitals NHS Trust. The health records of patients with resistant CSU who received Xolair (Omalizumab, Novartis) between the years 2017-2019 were reviewed. Omalizumab 300mg was administered subcutaneously with antihistamines every 4 weeks for 6 months, followed by an 8-week treatment interruption. In case of recurrence, further doses were approved after clinic review. Patient demographics, laboratory features (autoantibody status, IgE level, tryptase), weekly urticaria activity score (UAS7) during treatment were analysed. UAS7 at zero was considered complete remission (CR), UAS7 1-28 as partial remission (PR), UAS7>28 as non-responder (NR). Descriptive statistics including parametric and non-parametric tests were done using GraphPad Prism version 7.00 for Windows,</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7f8436b3bbede285b9c52d43d29e7673" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109491766,"asset_id":112182811,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109491766/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112182811"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112182811"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112182811; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112182811]").text(description); $(".js-view-count[data-work-id=112182811]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112182811; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112182811']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7f8436b3bbede285b9c52d43d29e7673" } } $('.js-work-strip[data-work-id=112182811]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112182811,"title":"Omalizumab retreatment rates in chronic spontaneous urticaria","internal_url":"https://www.academia.edu/112182811/Omalizumab_retreatment_rates_in_chronic_spontaneous_urticaria","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":109491766,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109491766/thumbnails/1.jpg","file_name":"letter-editorbromalizumab-retreatment-rates-chronic-spontaneous-urticaria-3687allasp1.pdf","download_url":"https://www.academia.edu/attachments/109491766/download_file","bulk_download_file_name":"Omalizumab_retreatment_rates_in_chronic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109491766/letter-editorbromalizumab-retreatment-rates-chronic-spontaneous-urticaria-3687allasp1-libre.pdf?1703411127=\u0026response-content-disposition=attachment%3B+filename%3DOmalizumab_retreatment_rates_in_chronic.pdf\u0026Expires=1740570100\u0026Signature=aaJsRiIcINIyTNT3UZfjc48CXsJeqE2cxrZtChRTF2bg5PIss3-VbxVRdWvd7ttEYnDIJON3c2xbKpNclkU6dQ4SkO7PCDEy5xkHaVKoYS5w60qb6LWY-0vvAeVjwXu0b7ilU9KuhYWi0kwfoiwq7lXghJoX3qt1gMfd8A6ih8R8dZNofccFitcxccHkgUIwqx8x2ztPy~cZOqSdKfoXDZuSPoDzXAMjsmxX4Hs0mjVXP4o0wcXF1b8IEYSbpkpJ9u1pX-sOKemG8QAF7qYyWjzn1HhGYKFOErXI2szp~C3PfGJ5psyAeAeVDX7Hg0DweroQPiB8P5ePk8a4lO50XA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112182730"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112182730/Do_ribosomopathies_explain_some_cases_of_common_variable_immunodeficiency"><img alt="Research paper thumbnail of Do ribosomopathies explain some cases of common variable immunodeficiency?" class="work-thumbnail" src="https://attachments.academia-assets.com/109491723/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112182730/Do_ribosomopathies_explain_some_cases_of_common_variable_immunodeficiency">Do ribosomopathies explain some cases of common variable immunodeficiency?</a></div><div class="wp-workCard_item"><span>Clinical and Experimental Immunology</span><span>, Nov 9, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The considerable clinical heterogeneity of patients with common variable immunodeficiency disorde...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The considerable clinical heterogeneity of patients with common variable immunodeficiency disorders (CVID) shares some similarity with bone-marrow failure disorders such as Diamond–Blackfan anaemia (DBA) and Shwachman–Diamond syndrome (SDS), now recognized as defects in ribosome biogenesis or ribosomopathies. The recognition of a patient with DBA who subsequently developed CVID lends support to our previous finding of a heterozygous mutation in the SBDS gene of SBDS in another CVID patient, suggesting that ribosome biogenesis defects are responsible for a subset of CVID. Genetic defects in the ribosomal translational machinery responsible for various bone marrow failure syndromes are recognized readily when they manifest in children, but diagnosing these in adults presenting with complex phenotypes and hypogammaglobulinaemia can be a challenge. In this perspective paper, we discuss our clinical experience in CVID patients with ribosomopathies, and review the immunological abnormalities in other conditions associated with ribosomal dysfunction. With genetic testing available for various bone marrow failure syndromes, our hypothesis that ribosomal abnormalities may be present in patients with CVID could be proved in future studies by testing for mutations in specific ribosomal genes. New knowledge might then be translated into novel therapeutic strategies for patients in this group of immunodeficiency disorders.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a13b6d9cd46b131e00c173c58af2faf3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109491723,"asset_id":112182730,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109491723/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112182730"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112182730"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112182730; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112182730]").text(description); $(".js-view-count[data-work-id=112182730]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112182730; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112182730']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a13b6d9cd46b131e00c173c58af2faf3" } } $('.js-work-strip[data-work-id=112182730]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112182730,"title":"Do ribosomopathies explain some cases of common variable immunodeficiency?","internal_url":"https://www.academia.edu/112182730/Do_ribosomopathies_explain_some_cases_of_common_variable_immunodeficiency","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":109491723,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109491723/thumbnails/1.jpg","file_name":"j.1365-2249.2010.04280.x.pdf","download_url":"https://www.academia.edu/attachments/109491723/download_file","bulk_download_file_name":"Do_ribosomopathies_explain_some_cases_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109491723/j.1365-2249.2010.04280.x-libre.pdf?1703403032=\u0026response-content-disposition=attachment%3B+filename%3DDo_ribosomopathies_explain_some_cases_of.pdf\u0026Expires=1740570100\u0026Signature=FTYJnoQtr-L6mgIGGgp5diAdP-uu9jgOKOtEHuRec5imOxDoic1nthaKmG7oIWcBb9vQ4dCk4VZfpp~n8lspW6svxC4PFqWMpqBpSOxhIrxDk0bPkcXN2LIRLbQwLs4DDEsklhvsHO~96UdYDQ9S1sjUW3zqsO7kJhHrvsYQPmeOyE87i~2CeXnDvU85wQe~dm5r6V3LPSAqJykex0KTNhYEBDoTyBlO-WZdWlmG2IaQzfXi2vTHUmYIxxEnzVco4N9n6mZZPEQXPYnQnSbb0ik~YxNGRcopfIvGI6V9YxtaaNVD0yorNCSVxtxm1rgofPylSXoCt6YhaGLM3TWYsA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112182727"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112182727/Outcomes_following_SARS_CoV_2_infection_in_patients_with_primary_and_secondary_immunodeficiency_in_the_UK"><img alt="Research paper thumbnail of Outcomes following SARS-CoV-2 infection in patients with primary and secondary immunodeficiency in the UK" class="work-thumbnail" src="https://attachments.academia-assets.com/109491696/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112182727/Outcomes_following_SARS_CoV_2_infection_in_patients_with_primary_and_secondary_immunodeficiency_in_the_UK">Outcomes following SARS-CoV-2 infection in patients with primary and secondary immunodeficiency in the UK</a></div><div class="wp-workCard_item"><span>Clinical and Experimental Immunology</span><span>, Jan 28, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In March 2020, the United Kingdom Primary Immunodeficiency Network (UKPIN) established a registry...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In March 2020, the United Kingdom Primary Immunodeficiency Network (UKPIN) established a registry of cases to collate the outcomes of individuals with PID and SID following SARS-CoV-2 infection and treatment. A total of 310 cases of SARS-CoV-2 infection in individuals with PID or SID have now been reported in the UK. The overall mortality within the cohort was 17.7% (n = 55/310). Individuals with CVID demonstrated an infection fatality rate (IFR) of 18.3% (n = 17/93), individuals with PID receiving IgRT had an IFR of 16.3% (n = 26/159) and individuals with SID, an IFR of 27.2% (n = 25/92). Individuals with PID and SID had higher inpatient mortality and died at a younger age than the general population. Increasing age, low pre-SARS-CoV-2 infection lymphocyte count and the presence of common co-morbidities increased the risk of mortality in PID. Access to specific COVID-19 treatments in this cohort was limited: only 22.9% (n = 33/144) of patients admitted to the hospital received dexamethasone, remdesivir, an anti-SARS-CoV-2 antibody-based therapeutic (e.g. REGN-COV2 or convalescent plasma) or tocilizumab as a monotherapy or in combination. Dexamethasone, remdesivir, and anti-SARS-CoV-2 antibody-based therapeutics appeared efficacious in PID and SID. Compared to the general population, individuals with PID or SID are at high risk of mortality following SARS-CoV-2 infection. Increasing age, low baseline lymphocyte count, and the presence of co-morbidities are additional risk factors for poor outcome in this cohort.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9f12160557f06ed18eb1b80048e015f3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109491696,"asset_id":112182727,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109491696/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112182727"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112182727"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112182727; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112182727]").text(description); $(".js-view-count[data-work-id=112182727]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112182727; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112182727']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9f12160557f06ed18eb1b80048e015f3" } } $('.js-work-strip[data-work-id=112182727]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112182727,"title":"Outcomes following SARS-CoV-2 infection in patients with primary and secondary immunodeficiency in the UK","internal_url":"https://www.academia.edu/112182727/Outcomes_following_SARS_CoV_2_infection_in_patients_with_primary_and_secondary_immunodeficiency_in_the_UK","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":109491696,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109491696/thumbnails/1.jpg","file_name":"uxac008.pdf","download_url":"https://www.academia.edu/attachments/109491696/download_file","bulk_download_file_name":"Outcomes_following_SARS_CoV_2_infection.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109491696/uxac008-libre.pdf?1703403036=\u0026response-content-disposition=attachment%3B+filename%3DOutcomes_following_SARS_CoV_2_infection.pdf\u0026Expires=1740570100\u0026Signature=RjRdYV66weSO6ajAOPANeOJm0qTtXZ4ZIENhSidUlFhHOTZGjw94K4o5jYGpiNZGRsmJ-unTd5oriqWX57Er4SvA1y8dZx0~ZqUv16W7h8yRS~AFHsiF1Q~jXHzXrfUjTb5sE1657j9tGnR846WLdh~CM7P~yhKVVnnpKSUbMU34EBXyhxVppppHByV6CyPjQRNt1MeItEofulksDzxTPH3YjzASXMoMgvUVB2vWSz1sKuga~Bf0h8hPX09ZoSBDeUjSoadayC6JkqCy9sLxRUMQ2FV15FqzfUOhzVGMaeThS7cm8iNBL1P4o4ofr3XKq7fJ82FURT~cDMYaBvrthg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":109491695,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109491695/thumbnails/1.jpg","file_name":"uxac008.pdf","download_url":"https://www.academia.edu/attachments/109491695/download_file","bulk_download_file_name":"Outcomes_following_SARS_CoV_2_infection.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109491695/uxac008-libre.pdf?1703403038=\u0026response-content-disposition=attachment%3B+filename%3DOutcomes_following_SARS_CoV_2_infection.pdf\u0026Expires=1740570100\u0026Signature=dEXPLs-bNkm~71k1muzLpRtVzblvs2oYPIbpMla65vL9dXTTUWJmsjly25mWjszPI3uS1NDqqH8san2yoUSo8hVTeZjxugTNzbULn7V5vx~iHyGJJs8-1OPugndpH2sgq1kTc18Txh2OH838AtU4n0yCVWyigrXtBlInDybJ-wDw07I7MMref7O8haWhhzbRxoa5-GVsXD-ci81DwX5TiNYVKHGtDjlinjJl8miKjx-AME1T5I8Yr5Z3lVbV9cx0q5uaw7A3BKdTvIlj6B1~bGc2WxnuZ2zb16VRj8Yn9~KGukkc74-ndyR0BBEsObIw4XRuhLdDR~WdajeiD5H~1A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112182723"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112182723/Aspergillus_fumigatus_IgG_level_greater_than_60_mg_L_Increases_Diagnostic_Specificity_of_Allergic_Bronchopulmonary_Aspergillosis"><img alt="Research paper thumbnail of Aspergillus fumigatus IgG level greater than 60 mg/L Increases Diagnostic Specificity of Allergic Bronchopulmonary Aspergillosis" class="work-thumbnail" src="https://attachments.academia-assets.com/109491719/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112182723/Aspergillus_fumigatus_IgG_level_greater_than_60_mg_L_Increases_Diagnostic_Specificity_of_Allergic_Bronchopulmonary_Aspergillosis">Aspergillus fumigatus IgG level greater than 60 mg/L Increases Diagnostic Specificity of Allergic Bronchopulmonary Aspergillosis</a></div><div class="wp-workCard_item"><span>The Journal of Allergy and Clinical Immunology</span><span>, Feb 1, 2018</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="443ed2e0a36db5eba2592e23110764ad" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109491719,"asset_id":112182723,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109491719/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112182723"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112182723"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112182723; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112182723]").text(description); $(".js-view-count[data-work-id=112182723]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112182723; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112182723']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "443ed2e0a36db5eba2592e23110764ad" } } $('.js-work-strip[data-work-id=112182723]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112182723,"title":"Aspergillus fumigatus IgG level greater than 60 mg/L Increases Diagnostic Specificity of Allergic Bronchopulmonary Aspergillosis","internal_url":"https://www.academia.edu/112182723/Aspergillus_fumigatus_IgG_level_greater_than_60_mg_L_Increases_Diagnostic_Specificity_of_Allergic_Bronchopulmonary_Aspergillosis","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":109491719,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109491719/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/109491719/download_file","bulk_download_file_name":"Aspergillus_fumigatus_IgG_level_greater.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109491719/pdf-libre.pdf?1703403029=\u0026response-content-disposition=attachment%3B+filename%3DAspergillus_fumigatus_IgG_level_greater.pdf\u0026Expires=1740570100\u0026Signature=IOuzush9~ghmJ2Nxb5o9wl7PmFlW~vK9hFd-h~PPS2DJMhWnnzfD~txcatoU8LDZWfWdSx7xwjCD1HQIfLGjaETkeKGuMb2OzRAe9plHepW1a8VfipBuOrvwarwCXFZIuslfkHYW-Qf74WMEXLtRceUobN3ZbibT4O1mgzQiML3F-eehmDFFYRV15DyzNJB3NQKO2WblcKABZe7ICiP~YoSrgstktHJNxM07kIDmtF5TOtaZNV57ZbSEkqcBilExjBJEPNHKbsZieeyBihjdV-dMT4GO~h2mD8vUUHDf273XGsVxLRYPS0~EYtVgUL9PIihpQjP8Yfpwr7mQ5X5KYg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112182720"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112182720/Impact_of_vaccination_on_hospitalization_and_mortality_from_COVID_19_in_patients_with_primary_and_secondary_immunodeficiency_The_United_Kingdom_experience"><img alt="Research paper thumbnail of Impact of vaccination on hospitalization and mortality from COVID-19 in patients with primary and secondary immunodeficiency: The United Kingdom experience" class="work-thumbnail" src="https://attachments.academia-assets.com/109491720/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112182720/Impact_of_vaccination_on_hospitalization_and_mortality_from_COVID_19_in_patients_with_primary_and_secondary_immunodeficiency_The_United_Kingdom_experience">Impact of vaccination on hospitalization and mortality from COVID-19 in patients with primary and secondary immunodeficiency: The United Kingdom experience</a></div><div class="wp-workCard_item"><span>Frontiers in Immunology</span><span>, Sep 23, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Individuals with primary and secondary immunodeficiency (PID/SID) were shown to be at...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Individuals with primary and secondary immunodeficiency (PID/SID) were shown to be at risk of poor outcomes during the early stages of the SARS-CoV-2 pandemic. SARS-CoV-2 vaccines demonstrate reduced immunogenicity in these patients. Objectives: To understand whether the risk of severe COVID-19 in individuals with PID or SID has changed following the deployment of vaccination and therapeutics in the context of the emergence of novel viral variants of concern.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="75990bc2da6660100f3616b1318b9992" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109491720,"asset_id":112182720,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109491720/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112182720"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112182720"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112182720; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112182720]").text(description); $(".js-view-count[data-work-id=112182720]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112182720; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112182720']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "75990bc2da6660100f3616b1318b9992" } } $('.js-work-strip[data-work-id=112182720]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112182720,"title":"Impact of vaccination on hospitalization and mortality from COVID-19 in patients with primary and secondary immunodeficiency: The United Kingdom experience","internal_url":"https://www.academia.edu/112182720/Impact_of_vaccination_on_hospitalization_and_mortality_from_COVID_19_in_patients_with_primary_and_secondary_immunodeficiency_The_United_Kingdom_experience","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":109491720,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109491720/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/109491720/download_file","bulk_download_file_name":"Impact_of_vaccination_on_hospitalization.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109491720/pdf-libre.pdf?1703403030=\u0026response-content-disposition=attachment%3B+filename%3DImpact_of_vaccination_on_hospitalization.pdf\u0026Expires=1740570100\u0026Signature=buYbAfRbHv8g4HGT3wqcaI06G6dk0MWiy9~ej2fOexVgn-LXvVM7Npmrw2xRnhENRjORS-2HFI8M0UY8lUfTERomlMaY-1ophazJ7cHGvWXPOVrClvIgKeDpk4bKlfD3xfQ9CLz4yMWrlIs3mSBk9ZeAQhQdLdwb-Mt3gsnKjtAjnGaRc4gDbwyy1u6tccdZpfbDeOWloB4dQsYP9eOh4wDjGwBtLcoW5CqrzmSsH6e87u-BrZSENTq1qH5jO22F3eNMWSCamCmrkdyAqhmNRaKr8y6dYdWssigzgGz~0kmNmTNl~S82GtLcSfuZdBFNjBrFc7DcX7fb~JuIQHD0pg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="2653849" id="papers"><div class="js-work-strip profile--work_container" data-work-id="116607642"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/116607642/Testing_for_Fecal_Calprotectin_in_Food_Protein_Induced_Enterocolitis_Syndrome"><img alt="Research paper thumbnail of Testing for Fecal Calprotectin in Food Protein–Induced Enterocolitis Syndrome" class="work-thumbnail" src="https://attachments.academia-assets.com/112690262/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/116607642/Testing_for_Fecal_Calprotectin_in_Food_Protein_Induced_Enterocolitis_Syndrome">Testing for Fecal Calprotectin in Food Protein–Induced Enterocolitis Syndrome</a></div><div class="wp-workCard_item"><span>Journal of Investigational Allergology and Clinical Immunology</span><span>, Aug 1, 2018</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fa6ffd38632568290dd1a767b1e7c52b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112690262,"asset_id":116607642,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112690262/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607642"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607642"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607642; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607642]").text(description); $(".js-view-count[data-work-id=116607642]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607642; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607642']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fa6ffd38632568290dd1a767b1e7c52b" } } $('.js-work-strip[data-work-id=116607642]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607642,"title":"Testing for Fecal Calprotectin in Food Protein–Induced Enterocolitis Syndrome","internal_url":"https://www.academia.edu/116607642/Testing_for_Fecal_Calprotectin_in_Food_Protein_Induced_Enterocolitis_Syndrome","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":112690262,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112690262/thumbnails/1.jpg","file_name":"d1a4a0065a7e676ac09796c13878ac562e4f.pdf","download_url":"https://www.academia.edu/attachments/112690262/download_file","bulk_download_file_name":"Testing_for_Fecal_Calprotectin_in_Food_P.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112690262/d1a4a0065a7e676ac09796c13878ac562e4f-libre.pdf?1711241804=\u0026response-content-disposition=attachment%3B+filename%3DTesting_for_Fecal_Calprotectin_in_Food_P.pdf\u0026Expires=1740570099\u0026Signature=a00mCanL6fyA~6K7QkUMamTzIQBLq0~1MVo-mcByxVMUgry900r3wGeCOMzsYtbkNpkMpJwu8EZS1e9gNevMn4u8GGuez6NXTmjvyy8tkW8n7Okj5rWBJGtE11dQlvwnIt3jNtcnOUFpOkOqnRPlXKUyRl7459piiJS3A9z5OyUYMv30~mweJz15lip38WlYN~mjIDWmN3JseyeLQka7dnf1H5SGB2Zk2CE1ojir2ZSM4Zc0qn20MGmzM7EC0Q85Fi8Y9uIQw4c7Hi81Y-d~aoF~ghoBwJVAmYnoRzezls0VGeAT1lNU1LteQ08FAQk9Zv5fkZsdKG28ST43KY-EHw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607640"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/116607640/JAK_Inhibition_as_a_Therapeutic_Strategy_for_IgG4_RD"><img alt="Research paper thumbnail of JAK Inhibition as a Therapeutic Strategy for IgG4-RD" class="work-thumbnail" src="https://attachments.academia-assets.com/112690260/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/116607640/JAK_Inhibition_as_a_Therapeutic_Strategy_for_IgG4_RD">JAK Inhibition as a Therapeutic Strategy for IgG4-RD</a></div><div class="wp-workCard_item"><span>Journal of Investigational Allergology and Clinical Immunology</span><span>, Jun 22, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The review by Carballo et al [1] provides an excellent summary of the varied clinical presentatio...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The review by Carballo et al [1] provides an excellent summary of the varied clinical presentations of IgG4-related disease (IgG4-RD), highlighting the role of clinicians and insisting on a detailed pathological description of affected organs with IgG4-stained plasmablasts infiltrating tissues to arrive at a diagnosis. However, the cytokine environment and what makes this "nonpathogenic" IgG isotype cause irreversible end-organ damage remains unknown. As the authors rightly discuss, both autoimmune and allergic aspects of IgG4-RD are involved. In addition to the general approach to managing the diverse clinical presentations of this disease, we would like to discuss the cytokine signalling involved in IgG4-RD in more detail and suggest Janus-associated kinase (JAK) inhibition as alternative therapeutic strategy to manage this condition. Autoimmunity implies a perpetual cycle that is initiated by a cell-damaging event that modifies self-antigens. Tissueresident antigen-presenting cells increase MHC class II expression and present modified antigens to T cells, and the unique cytokine environment switches CD4 + T H 2 T-cell differentiation, which in turn drives an adaptive immune response towards IgG4 plasma cell differentiation and, eventually, end-organ damage with fibrosis (Figure). The pathogenic role of IgG4 was shown to involve passive transfer of antibodies from patients with IgG4-RD causing pancreatic and salivary gland injury in neonatal Balb/c mice [2]. Distinct glycosylation changes on IgG4 with increased G0 and F1 glycans in patients with IgG4-RD and hypocomplementemia suggest activation of the lectin pathway on phagocytes to induce chronic inflammation [3,4]. Interestingly, in the pancreatic ovalbumin mouse model</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7fc82e8c2a4da60ba83dec7ed42821cf" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112690260,"asset_id":116607640,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112690260/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607640"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607640"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607640; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607640]").text(description); $(".js-view-count[data-work-id=116607640]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607640; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607640']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7fc82e8c2a4da60ba83dec7ed42821cf" } } $('.js-work-strip[data-work-id=116607640]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607640,"title":"JAK Inhibition as a Therapeutic Strategy for IgG4-RD","internal_url":"https://www.academia.edu/116607640/JAK_Inhibition_as_a_Therapeutic_Strategy_for_IgG4_RD","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":112690260,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112690260/thumbnails/1.jpg","file_name":"vol31issue3_7.pdf","download_url":"https://www.academia.edu/attachments/112690260/download_file","bulk_download_file_name":"JAK_Inhibition_as_a_Therapeutic_Strategy.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112690260/vol31issue3_7-libre.pdf?1711241802=\u0026response-content-disposition=attachment%3B+filename%3DJAK_Inhibition_as_a_Therapeutic_Strategy.pdf\u0026Expires=1740570099\u0026Signature=ejlRFxAGd4zGYaVQK0DtPiPUFQ4KKb17vaXJBOW62-x75hYMoXX8nbyS51jrlbMRZffzFHii2LZBKjDe92ztldaw6btPOqhXiYJnKPi9XDjd28R59pcyrf-SI91v2FdJBC0Qa~YP4g8~sDFkMoR0quZXtmGUbxYyOXDa6ngI-JsaerSMl9RYbyccrBvp9xmEsggY~QbtW-aSuO4~~H6sOWWGVwa8dKKh9sexgoS8dWAXbGSN1Z26fF2vQGiQgtM5bCMjbbm5KoNviQpydaziWrKk7MOftqEZsW2krfrOJBPMagd5u11Gs2XICdekByJNnVc93nHtuWSZSqyAJNoVTg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607637"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/116607637/Routine_testing_not_beneficial_in_evaluation_of_patients_with_chronic_spontaneous_urticaria"><img alt="Research paper thumbnail of Routine testing not beneficial in evaluation of patients with chronic spontaneous urticaria" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/116607637/Routine_testing_not_beneficial_in_evaluation_of_patients_with_chronic_spontaneous_urticaria">Routine testing not beneficial in evaluation of patients with chronic spontaneous urticaria</a></div><div class="wp-workCard_item"><span>Indian Dermatology Online Journal</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">© 2020 Indian Dermatology Online Journal | Published by Wolters Kluwer Medknow Dear Editor, We re...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">© 2020 Indian Dermatology Online Journal | Published by Wolters Kluwer Medknow Dear Editor, We read with interest the paper by Shailaja Chauhan and colleagues where they found that elevated plasma levels of D‐dimer in patients with chronic spontaneous urticaria (CSU) may influence treatment options,[1] but the tests did not make any difference in the overall management of patients. We present our experience with a quality improvement project, which determined the usefulness of routine testing in CSU. The British Society of Allergy &amp; Clinical Immunology guidelines[2] were used as standards [Table 1] and was approved by the Clinical Audit and Effectiveness Team of Hull University Teaching Hospitals NHS Trust. Patients with CSU were identified from clinic letters. The first phase (Plan, Do, Study Act Cycle 1) reviewed 169 new consultations for 7 months between September 2018 and March 2019, with a follow‐ up phase (PDSA Cycle 2) of 190 new consultations for 4 months between September 2019 and December 2019. Performances with regards to standards are shown in Table 1.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607637"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607637"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607637; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607637]").text(description); $(".js-view-count[data-work-id=116607637]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607637; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607637']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=116607637]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607637,"title":"Routine testing not beneficial in evaluation of patients with chronic spontaneous urticaria","internal_url":"https://www.academia.edu/116607637/Routine_testing_not_beneficial_in_evaluation_of_patients_with_chronic_spontaneous_urticaria","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607635"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/116607635/JAK_Inhibition_with_Methotrexate_as_Treatment_for_COVID_19_Is_a_Double_Edged_Sword"><img alt="Research paper thumbnail of JAK Inhibition with Methotrexate as Treatment for COVID-19 Is a Double-Edged Sword" class="work-thumbnail" src="https://attachments.academia-assets.com/112690249/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/116607635/JAK_Inhibition_with_Methotrexate_as_Treatment_for_COVID_19_Is_a_Double_Edged_Sword">JAK Inhibition with Methotrexate as Treatment for COVID-19 Is a Double-Edged Sword</a></div><div class="wp-workCard_item"><span>International Archives of Allergy and Immunology</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8491ad0275260b328153a5eab22ed1eb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112690249,"asset_id":116607635,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112690249/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607635"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607635"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607635; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607635]").text(description); $(".js-view-count[data-work-id=116607635]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607635; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607635']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8491ad0275260b328153a5eab22ed1eb" } } $('.js-work-strip[data-work-id=116607635]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607635,"title":"JAK Inhibition with Methotrexate as Treatment for COVID-19 Is a Double-Edged Sword","internal_url":"https://www.academia.edu/116607635/JAK_Inhibition_with_Methotrexate_as_Treatment_for_COVID_19_Is_a_Double_Edged_Sword","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":112690249,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112690249/thumbnails/1.jpg","file_name":"000508750.pdf","download_url":"https://www.academia.edu/attachments/112690249/download_file","bulk_download_file_name":"JAK_Inhibition_with_Methotrexate_as_Trea.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112690249/000508750-libre.pdf?1711241803=\u0026response-content-disposition=attachment%3B+filename%3DJAK_Inhibition_with_Methotrexate_as_Trea.pdf\u0026Expires=1740570099\u0026Signature=GNvbgqBsJFy5lgP5n2P4IOZwjfapYpJHithxN9of--ur6bwLeIN6~Lwj5Odxrz0L5FL5RyzOIemUVc1y0cE36zfUQ9GzVqFE8Sr2LFG-lxmFPkLyJvPyUFLlxor~ZqNlyTytHSzKyZDdkVcOmb-gC2P3h6v9gFVxfPVEGQLRM2HPmhO~~nxRWLMJ0ZvfJTCMzq8RlmKCjRihDzmrteIadnbCY6W9DpvN3EZTPisS6ibtXMVDG-N7ddWPwDKk4m8N5DliCbGBKIL61b6nurceRkoVFGlnIILnnfB3D-LauO72QaArZoHDe-y0huy7r6xNDljeHuXFhjkHNsUc3Pkjpw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":112690250,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112690250/thumbnails/1.jpg","file_name":"000508750.pdf","download_url":"https://www.academia.edu/attachments/112690250/download_file","bulk_download_file_name":"JAK_Inhibition_with_Methotrexate_as_Trea.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112690250/000508750-libre.pdf?1711241803=\u0026response-content-disposition=attachment%3B+filename%3DJAK_Inhibition_with_Methotrexate_as_Trea.pdf\u0026Expires=1740570099\u0026Signature=LT~XV4deLfIzUY4GdlKSp0a3ahrN8iyxz1QlnecKi8zUeEsrXfutIliwyaARHNxZEtL0Ve8IttxoiuWg62Ds3SBFiuAFuCTadrtsb8EkUG-3Pppy~pNuzlA8OVY-m5VplmJeRUnMvA50NGFwgPM3FvdLk9L1tZNLuZVleItNZURj9g9XXE0-azc~nxzqBk-1EKaciAEJokgms7LwgmjHikJL0QglGJbk7zozSjIJBT85YXOM3KOaERPg~1dIhvmd1jAwKJlixbpvb2k7uiAL7j-f40vHAzOlEQQlRl2jv85MGC9vnXTZoLRIpCZw8lwIqVhccUupRM2XMVopFEs5VA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607634"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/116607634/Interstitial_lung_disease_in_common_variable_immunodeficiency"><img alt="Research paper thumbnail of Interstitial lung disease in common variable immunodeficiency" class="work-thumbnail" src="https://attachments.academia-assets.com/112690261/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/116607634/Interstitial_lung_disease_in_common_variable_immunodeficiency">Interstitial lung disease in common variable immunodeficiency</a></div><div class="wp-workCard_item"><span>British journal of hospital medicine</span><span>, Dec 20, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Drug hypersensitivity reactions (DHR) are frequently encountered in clinical practice, and often ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Drug hypersensitivity reactions (DHR) are frequently encountered in clinical practice, and often result in significant morbidity and mortality. Diagnosis of DHR is based upon clinical signs, symptomatology and biochemical parameters, and is frequently complicated by factors including polypharmacy and difficulty excluding conditions mimicking DHR. Currently available laboratory assays employed in the work-up of DHR include evaluation of lymphocytes, basophils and other cell types in peripheral blood specimens after ex-vivo stimulation with the culprit drug in the convalescent phase, several weeks after the initial reaction. There are no robust tests available for diagnosing DHR at the time of the reaction. The ability to diagnose and differentiate between various reaction types during the acute phase would facilitate early identification and specific management of affected patients. Up-regulation of several cell surface activation markers have been described in the context of Type 4 DHR, including CD69 which becomes up-regulated in various cell types, increased expression of CD40L, HLA-DR and CD25 on T cells, and up-regulation of CD107a and cytoplasmic perforin and granzyme in NK and cytotoxic T cells. 1 We present a case-based discussion of patterns of immune activation in the peripheral blood of patients presenting with acute DHR, and describe the differential up-regulation of various cell surface and cytoplasmic markers in different DHR sub-types. Reference 1. Porebski G, Gschwend-Zawodniak A, Pichler WJ. In vitro diagnosis of T cell-mediated drug allergy. Clin Exp Allergy 2011; 41: 461-70.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b90b376d71075cbe32c7531289ba9267" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112690261,"asset_id":116607634,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112690261/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607634"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607634"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607634; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607634]").text(description); $(".js-view-count[data-work-id=116607634]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607634; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607634']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b90b376d71075cbe32c7531289ba9267" } } $('.js-work-strip[data-work-id=116607634]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607634,"title":"Interstitial lung disease in common variable immunodeficiency","internal_url":"https://www.academia.edu/116607634/Interstitial_lung_disease_in_common_variable_immunodeficiency","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":112690261,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112690261/thumbnails/1.jpg","file_name":"01.pat.0000461429.97369.e720240323-1-ebykd9.pdf","download_url":"https://www.academia.edu/attachments/112690261/download_file","bulk_download_file_name":"Interstitial_lung_disease_in_common_vari.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112690261/01.pat.0000461429.97369.e720240323-1-ebykd9-libre.pdf?1711241802=\u0026response-content-disposition=attachment%3B+filename%3DInterstitial_lung_disease_in_common_vari.pdf\u0026Expires=1740570099\u0026Signature=TctA53LEcwsJT0xY8iDSmnke0RoCREs5yjrqk44cP7U82BaklXLBN~TBk5csGO18vv4h3ifL~I6~Dyiz6WORfNvAgxoXw4W7Q5liuWiZYpvpfFbD6UqeAyK7U4zd58eEjiYZMVflt-aL24Gz2mAc1QW0cN~oLQ29y~lYSITbWnp2T1ppFYCL-9sexV1YJQVcO6AKbp~HwOCOFOboXN~RvgoeKFf8B1pX7XxB29s3xL9cEbwB3fyBFMDtd483WHs8CF0XWiE80gQA-g3AIM4p2c~l7zGzlA3nUtxpByg3iqjxzinhXg~z6h7DfagNJaRwNoLNUGv2fJixcZCGK~P9SQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607631"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/116607631/Psoriasis"><img alt="Research paper thumbnail of Psoriasis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/116607631/Psoriasis">Psoriasis</a></div><div class="wp-workCard_item"><span>The New England Journal of Medicine</span><span>, Aug 25, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607631"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607631"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607631; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607631]").text(description); $(".js-view-count[data-work-id=116607631]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607631; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607631']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=116607631]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607631,"title":"Psoriasis","internal_url":"https://www.academia.edu/116607631/Psoriasis","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607630"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/116607630/House_dust_mite_allergy_is_a_major_cause_for_respiratory_symptoms_and_sleep_disorders_in_young_children"><img alt="Research paper thumbnail of House dust mite allergy is a major cause for respiratory symptoms and sleep disorders in young children" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/116607630/House_dust_mite_allergy_is_a_major_cause_for_respiratory_symptoms_and_sleep_disorders_in_young_children">House dust mite allergy is a major cause for respiratory symptoms and sleep disorders in young children</a></div><div class="wp-workCard_item"><span>Lung India</span><span>, 2022</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607630"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607630"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607630; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607630]").text(description); $(".js-view-count[data-work-id=116607630]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607630; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607630']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=116607630]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607630,"title":"House dust mite allergy is a major cause for respiratory symptoms and sleep disorders in young children","internal_url":"https://www.academia.edu/116607630/House_dust_mite_allergy_is_a_major_cause_for_respiratory_symptoms_and_sleep_disorders_in_young_children","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607629"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/116607629/Managing_patients_with_Th2_severe_refractory_asthma_with_bronchial_thermoplasty"><img alt="Research paper thumbnail of Managing patients with Th2 severe refractory asthma with bronchial thermoplasty" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/116607629/Managing_patients_with_Th2_severe_refractory_asthma_with_bronchial_thermoplasty">Managing patients with Th2 severe refractory asthma with bronchial thermoplasty</a></div><div class="wp-workCard_item"><span>Journal of precision respiratory medicine</span><span>, Oct 1, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607629"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607629"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607629; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607629]").text(description); $(".js-view-count[data-work-id=116607629]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607629; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607629']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=116607629]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607629,"title":"Managing patients with Th2 severe refractory asthma with bronchial thermoplasty","internal_url":"https://www.academia.edu/116607629/Managing_patients_with_Th2_severe_refractory_asthma_with_bronchial_thermoplasty","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607628"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/116607628/Nimesulide_and_adverse_drug_reactions_Time_for_a_database"><img alt="Research paper thumbnail of Nimesulide and adverse drug reactions: Time for a database" class="work-thumbnail" src="https://attachments.academia-assets.com/112695930/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/116607628/Nimesulide_and_adverse_drug_reactions_Time_for_a_database">Nimesulide and adverse drug reactions: Time for a database</a></div><div class="wp-workCard_item"><span>Journal of Postgraduate Medicine</span><span>, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="56a069ccdec4ca67a7dd42aaa7fad1f1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112695930,"asset_id":116607628,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112695930/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607628"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607628"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607628; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607628]").text(description); $(".js-view-count[data-work-id=116607628]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607628; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607628']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "56a069ccdec4ca67a7dd42aaa7fad1f1" } } $('.js-work-strip[data-work-id=116607628]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607628,"title":"Nimesulide and adverse drug reactions: Time for a database","internal_url":"https://www.academia.edu/116607628/Nimesulide_and_adverse_drug_reactions_Time_for_a_database","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":112695930,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112695930/thumbnails/1.jpg","file_name":"jp08086.pdf","download_url":"https://www.academia.edu/attachments/112695930/download_file","bulk_download_file_name":"Nimesulide_and_adverse_drug_reactions_Ti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112695930/jp08086-libre.pdf?1711265145=\u0026response-content-disposition=attachment%3B+filename%3DNimesulide_and_adverse_drug_reactions_Ti.pdf\u0026Expires=1740570099\u0026Signature=CA-U9nNWmzB7TvIyPoVayTSwcVgsnIxxZfRSniaOylEqLSIJs0XjiV2~XBRmuossEKWPG8l7aQpBnKAFlcqq2oCfa9H3bFO3i3y3BlX0jpNm6C3aOzEMOLV8QBzIrTDSLM7qQo-uZUAcYOEVT7oH-H4moVpLmXvEDhcSyIkGhD6~U4MLIGqrSMIZrqAWyqWm5dqZKZhHQYo5oWisVOCQqRGmdqSGYt1H7dRkyxSMJ1MxQf7D8GbgGnEBO5tDCvO~10dUi6MEqJdfFOBtwvP9T6g1LYNkkIkQieHHMyHuyJ7ddFoE7j8I7O1y1CW0GEneaoLE2bR7QdKai4GBGDxIHg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607627"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/116607627/Celiac_Disease_in_Children_%C3%A2_A_Profile_from_a_Predominantly_Rice_EatingPopulation"><img alt="Research paper thumbnail of Celiac Disease in Children â A Profile from a Predominantly Rice EatingPopulation" class="work-thumbnail" src="https://attachments.academia-assets.com/112690259/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/116607627/Celiac_Disease_in_Children_%C3%A2_A_Profile_from_a_Predominantly_Rice_EatingPopulation">Celiac Disease in Children â A Profile from a Predominantly Rice EatingPopulation</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">India had entered into the global scenario of celiac disease with Northern India being the celiac...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">India had entered into the global scenario of celiac disease with Northern India being the celiac belt. But prevalence studies are lacking from the Eastern part of India.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1070dae390dae7414ebebad1710dda80" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112690259,"asset_id":116607627,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112690259/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607627"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607627"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607627; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607627]").text(description); $(".js-view-count[data-work-id=116607627]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607627; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607627']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1070dae390dae7414ebebad1710dda80" } } $('.js-work-strip[data-work-id=116607627]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607627,"title":"Celiac Disease in Children â A Profile from a Predominantly Rice EatingPopulation","internal_url":"https://www.academia.edu/116607627/Celiac_Disease_in_Children_%C3%A2_A_Profile_from_a_Predominantly_Rice_EatingPopulation","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":112690259,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112690259/thumbnails/1.jpg","file_name":"celiac-disease-in-children--a-profile-from-a-predominantly-rice-eatingpopulation.pdf","download_url":"https://www.academia.edu/attachments/112690259/download_file","bulk_download_file_name":"Celiac_Disease_in_Children_a_A_Profile_f.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112690259/celiac-disease-in-children--a-profile-from-a-predominantly-rice-eatingpopulation-libre.pdf?1711241804=\u0026response-content-disposition=attachment%3B+filename%3DCeliac_Disease_in_Children_a_A_Profile_f.pdf\u0026Expires=1740570099\u0026Signature=cgvFXJtNGZ2yDG2JKHAJXoui08mEort3UWjxHqRhWuxM~W1Atd0lEAouMw2eg7OMABI7jQuN-yCdgCd7eh46qBZwuUFTyFUoGHRzxsRIF3a9SzsPM6lzgXt4S6y1wTzGqOFTXkSa6scLwLhiNQp2qBNj3BdnE2LVwhxNUGeY9AqfWJ7uk88aTvonUnKXG84vNW9u3s6dyRqvgS1cXYfaJLkVro5XRU4so0bIDKG4yJMDpPAumwMRKoPGUF07L~1GBRLpozf7umuPkqAOjIVexCaW82Bv810Re3T4qFhNkUKtImSI-SYL-No9~oinLEiToaX6ysbx9KPU1j~BAqTIAg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607626"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/116607626/Evaluating_sensitization_patterns_on_ImmunoCAP_detected_polysensitized_patients_with_microarray_based_multiplex_assay_ISAC_"><img alt="Research paper thumbnail of Evaluating sensitization patterns on ImmunoCAP-detected polysensitized patients with microarray-based multiplex assay (ISAC)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/116607626/Evaluating_sensitization_patterns_on_ImmunoCAP_detected_polysensitized_patients_with_microarray_based_multiplex_assay_ISAC_">Evaluating sensitization patterns on ImmunoCAP-detected polysensitized patients with microarray-based multiplex assay (ISAC)</a></div><div class="wp-workCard_item"><span>Journal of Allergy and Clinical Immunology</span><span>, 2021</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607626"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607626"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607626; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607626]").text(description); $(".js-view-count[data-work-id=116607626]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607626; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607626']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=116607626]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607626,"title":"Evaluating sensitization patterns on ImmunoCAP-detected polysensitized patients with microarray-based multiplex assay (ISAC)","internal_url":"https://www.academia.edu/116607626/Evaluating_sensitization_patterns_on_ImmunoCAP_detected_polysensitized_patients_with_microarray_based_multiplex_assay_ISAC_","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="116607607"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/116607607/Emerging_and_Reemerging_Sexually_Transmitted_Infections"><img alt="Research paper thumbnail of Emerging and Reemerging Sexually Transmitted Infections" class="work-thumbnail" src="https://attachments.academia-assets.com/112690242/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/116607607/Emerging_and_Reemerging_Sexually_Transmitted_Infections">Emerging and Reemerging Sexually Transmitted Infections</a></div><div class="wp-workCard_item"><span>New England Journal of Medicine</span><span>, 2020</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2aa75463e13ac744f9bd70e4317c2f6c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":112690242,"asset_id":116607607,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/112690242/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="116607607"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="116607607"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 116607607; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=116607607]").text(description); $(".js-view-count[data-work-id=116607607]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 116607607; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='116607607']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2aa75463e13ac744f9bd70e4317c2f6c" } } $('.js-work-strip[data-work-id=116607607]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":116607607,"title":"Emerging and Reemerging Sexually Transmitted Infections","internal_url":"https://www.academia.edu/116607607/Emerging_and_Reemerging_Sexually_Transmitted_Infections","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":112690242,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/112690242/thumbnails/1.jpg","file_name":"emerging-and-reemerging-sexually-transmitted-infections.pdf","download_url":"https://www.academia.edu/attachments/112690242/download_file","bulk_download_file_name":"Emerging_and_Reemerging_Sexually_Transmi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/112690242/emerging-and-reemerging-sexually-transmitted-infections-libre.pdf?1711241805=\u0026response-content-disposition=attachment%3B+filename%3DEmerging_and_Reemerging_Sexually_Transmi.pdf\u0026Expires=1740570100\u0026Signature=fwul7GDbyOdeJcaZAdZ0uy82LDLxHJNq~9veSAT0mftaXguEL2bhNyW1iBAK7DKkTuklPTLoQkNpTjFR~LCmNGwz4mQfTATSPaD6Ej5vQ6hRCFCcHbLNS5bdiYb5tFMxAKpiyNWSok4dL9iH5OohK20WaTcowr0NY9TA8sWcQkVqCgUq8-weOldtP5D91FjmY7w8-r2m3mfv2bdTJbYJz0eO4A5inuZBotauj6AoVjUoidcLqt4UBE1H5Ut86afHRnHgevk9UqS7E~oS3ExKnx39i-DWmzmEvQetNya3aVd4nJ6Y0KZGEjrrj0OreTagoUVyMjk7rMpW31cu4s~Ywg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112182814"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112182814/An_updated_perspective_on_immunoglobulin_replacement_in_chronic_lymphocytic_leukaemia_in_the_era_of_targeted_therapies"><img alt="Research paper thumbnail of An updated perspective on immunoglobulin replacement in chronic lymphocytic leukaemia in the era of targeted therapies" class="work-thumbnail" src="https://attachments.academia-assets.com/109491743/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112182814/An_updated_perspective_on_immunoglobulin_replacement_in_chronic_lymphocytic_leukaemia_in_the_era_of_targeted_therapies">An updated perspective on immunoglobulin replacement in chronic lymphocytic leukaemia in the era of targeted therapies</a></div><div class="wp-workCard_item"><span>Frontiers in Oncology</span><span>, Apr 6, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Chronic lymphocytic leukaemia (CLL) is a malignancy of clonally expanded antigen-switched, neopla...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Chronic lymphocytic leukaemia (CLL) is a malignancy of clonally expanded antigen-switched, neoplastic, mature B cells. CLL is characterised by a variable degree of immunosuppression and secondary hypogammaglobulinemia. B-cell depleting therapies have historically been deployed with a proportion of patients becoming resistant to multiple lines of treatment with an associated worsening of immunosuppression and heightened infection risk. Advances in molecular diagnostics and the development of new therapies targeting Bruton's tyrosine kinase and B-cell lymphoma-2 have resulted in novel insights into the cellular mechanisms associated with an increased infection risk and T-cell escape from the complex tumour environment found in CLL. Generally, immunoglobulin replacement therapy with polyvalent human immunoglobulin G (IgG) is indicated in patients with recurrent severe bacterial infections and low IgG levels, but there is no consensus on the threshold IgG level for initiation of such therapy. A proportion of CLL patients have residual IgG production, with preserved quality of the immunoglobulin molecules, and therefore a definition of 'IgG quality' may allow for lower dosing or less frequent treatment with immunoglobulin therapy in such patients. Immunoglobulin therapy can restore innate immunity and in conjunction with CLL targeted therapies may allow T-cell antigen priming, restore T-cell function thereby providing an escape from tumour-associated autoimmunity and the development of an immune-mediated anti-tumour effect. This review aims to discuss the mechanisms by which CLL-targeted therapy may exert a synergistic therapeutic effect with immunoglobulin replacement therapy both in terms of reducing tumour bulk and restoration of immune function. KEYWORDS C L L , h y p o g a m m a g l o b u l i n e m i a , I g r e p l a c e m e n t , i m m u n o m o d u l a t i o n , restoration immunity Frontiers in Oncology frontiersin.org 01</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5f7efd41ed1f2ad53302528109a589c7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109491743,"asset_id":112182814,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109491743/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112182814"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112182814"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112182814; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112182814]").text(description); $(".js-view-count[data-work-id=112182814]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112182814; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112182814']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5f7efd41ed1f2ad53302528109a589c7" } } $('.js-work-strip[data-work-id=112182814]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112182814,"title":"An updated perspective on immunoglobulin replacement in chronic lymphocytic leukaemia in the era of targeted therapies","internal_url":"https://www.academia.edu/112182814/An_updated_perspective_on_immunoglobulin_replacement_in_chronic_lymphocytic_leukaemia_in_the_era_of_targeted_therapies","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":109491743,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109491743/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/109491743/download_file","bulk_download_file_name":"An_updated_perspective_on_immunoglobulin.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109491743/pdf-libre.pdf?1703403032=\u0026response-content-disposition=attachment%3B+filename%3DAn_updated_perspective_on_immunoglobulin.pdf\u0026Expires=1740570100\u0026Signature=Ex6WPm71vtCSHBaZtDTyugUxnky0rTRcJfszQvaDbdT6HIX4c7bTn3nXKVbEz9ghXsSBBh96VQ-faLBmo~vTNmadR1NbNFNFHSwsKdaJOi9eK~a7lVOw7~4TlkClpMFyAhANRTiHbmmcvkQIx0mV5CGYzPIZdqsMJZG7ERkcFKq7HEqB1n8ukva6~Qi4EK1B-hBxswv4jfTIEyUTpoDKKfeD-UUA49mp1gT4ukMcKQjBKmpfzqzkUeeTBWCTTOiix06dKYSm9nw~izbjpkWzT-qfYAOck5DLe-xPuAiGjhUMzS5~F2mTKGCCmiT~NLOkQ3Z0Sy~gF988nK0XyNV9zg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112182813"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/112182813/Immunomodulation_mediated_by_polyclonal_IgG_replacement_in_patients_with_chronic_lymphocytic_leukemia_may_be_important_in_infection_prevention"><img alt="Research paper thumbnail of Immunomodulation mediated by polyclonal IgG replacement in patients with chronic lymphocytic leukemia may be important in infection prevention" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/112182813/Immunomodulation_mediated_by_polyclonal_IgG_replacement_in_patients_with_chronic_lymphocytic_leukemia_may_be_important_in_infection_prevention">Immunomodulation mediated by polyclonal IgG replacement in patients with chronic lymphocytic leukemia may be important in infection prevention</a></div><div class="wp-workCard_item"><span>Hematological Oncology</span><span>, May 2, 2022</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112182813"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112182813"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112182813; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112182813]").text(description); $(".js-view-count[data-work-id=112182813]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112182813; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112182813']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=112182813]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112182813,"title":"Immunomodulation mediated by polyclonal IgG replacement in patients with chronic lymphocytic leukemia may be important in infection prevention","internal_url":"https://www.academia.edu/112182813/Immunomodulation_mediated_by_polyclonal_IgG_replacement_in_patients_with_chronic_lymphocytic_leukemia_may_be_important_in_infection_prevention","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112182812"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112182812/Outcomes_following_SARS_CoV_2_infection_in_patients_with_chronic_liver_disease_An_international_registry_study"><img alt="Research paper thumbnail of Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study" class="work-thumbnail" src="https://attachments.academia-assets.com/109491770/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112182812/Outcomes_following_SARS_CoV_2_infection_in_patients_with_chronic_liver_disease_An_international_registry_study">Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study</a></div><div class="wp-workCard_item"><span>Journal of Hepatology</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background & Aims: Chronic liver disease (CLD) and cirrhosis are associated with immune dysregula...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background & Aims: Chronic liver disease (CLD) and cirrhosis are associated with immune dysregulation, leading to concerns that affected patients may be at risk of adverse outcomes following SARS-CoV-2 infection. We aimed to determine the impact of COVID-19 on patients with pre-existing liver disease, which currently remains ill-defined. Methods: Between 25th March and 8th July 2020, data on 745 patients with CLD and SARS-CoV-2 (including 386 with and 359 without cirrhosis) were collected by 2 international registries and compared to data on non-CLD patients with SARS-CoV-2 from a UK hospital network. Results: Mortality was 32% in patients with cirrhosis compared to 8% in those without (p <0.001). Mortality in patients with cirrhosis increased according to Child-Pugh class (A [19%], B [35%], C [51%]) and the main cause of death was from respiratory failure (71%). After adjusting for baseline characteristics, factors associated with death in the total CLD cohort were age (odds ratio [OR] 1.02; 1.01-1.04), Child-Pugh A (OR 1.90; 1.03-3.52), B (OR 4.14; 2.4-7.65), or C (OR 9.32; 4.80-18.08) cirrhosis and alcohol-related liver disease (OR 1.79; 1.03-3.13). Compared to patients without CLD (n = 620), propensity-score-matched analysis revealed significant increases in mortality in those with Child-Pugh B (+20.0% [8.8%-31.3%]) and C (+38.1% [27.1%-49.2%]) cirrhosis. Acute hepatic decompensation occurred in 46% of patients with cirrhosis, of whom 21% had no respiratory symptoms. Half of those with hepatic decompensation had acute-on-chronic liver failure. Conclusions: In the largest such cohort to date, we demonstrate that baseline liver disease stage and alcohol-related liver disease are independent risk factors for death from COVID-19. These data have important implications for the risk stratification of patients with CLD across the globe during the COVID-19 pandemic. Lay summary: This international registry study demonstrates that patients with cirrhosis are at increased risk of death from COVID-19. Mortality from COVID-19 was particularly high among</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="23e1bf498025f9935266e15f79dfabda" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109491770,"asset_id":112182812,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109491770/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112182812"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112182812"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112182812; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112182812]").text(description); $(".js-view-count[data-work-id=112182812]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112182812; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112182812']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "23e1bf498025f9935266e15f79dfabda" } } $('.js-work-strip[data-work-id=112182812]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112182812,"title":"Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study","internal_url":"https://www.academia.edu/112182812/Outcomes_following_SARS_CoV_2_infection_in_patients_with_chronic_liver_disease_An_international_registry_study","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":109491770,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109491770/thumbnails/1.jpg","file_name":"download_file.pdf","download_url":"https://www.academia.edu/attachments/109491770/download_file","bulk_download_file_name":"Outcomes_following_SARS_CoV_2_infection.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109491770/download_file-libre.pdf?1703411135=\u0026response-content-disposition=attachment%3B+filename%3DOutcomes_following_SARS_CoV_2_infection.pdf\u0026Expires=1740570100\u0026Signature=FIHkb-JZT4BUDcd~EtBIHuhWSmwJDfStOYrrvPRzfyCojNDLaUQPX5ETwO2nW8GgP8B2by9dJ4IBgPhsrT-SKLIJj-iS9DXAh9lBkuexaTeXByq7oBBSpgIY2S81fYq8sA2KLAX9xZ6LwIvPxM3G5l48jeTqvzsjSy82~IeQOwO37EWfS6LwRJIRkQJwmyIw67vhSsuVFbSj39xhcvEyxICh5NF0HgTkBi115MNcMYnA-c3Hla7lIb5K2TXV0aqjqRVeue~-lvoSxNSqM--iste33QgLkFdZepGra~vuMrEZ3~qKJEQRo1IFcDiYXg-C18tQyOld8qYNkcOeqcdelA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112182811"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112182811/Omalizumab_retreatment_rates_in_chronic_spontaneous_urticaria"><img alt="Research paper thumbnail of Omalizumab retreatment rates in chronic spontaneous urticaria" class="work-thumbnail" src="https://attachments.academia-assets.com/109491766/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112182811/Omalizumab_retreatment_rates_in_chronic_spontaneous_urticaria">Omalizumab retreatment rates in chronic spontaneous urticaria</a></div><div class="wp-workCard_item"><span>European Annals of Allergy and Clinical Immunology</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Omalizumab re-treatment rates in chronic spontaneous urticaria The review paper by Tonacci A and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Omalizumab re-treatment rates in chronic spontaneous urticaria The review paper by Tonacci A and colleagues highlights the fact that re-treatment with omalizumab for patients with chronic spontaneous urticaria (CSU) is not unusual, which adds significantly to costs of treatment [1]. Our experience with use of omalizumab in CSU has been similar and treatment responses with re-treatment rates are presented. The study was part of an outcome reporting audit aimed to document (1) efficacy; (2) safety profile; (3) failure rates; and (4) identification of factors relating to efficacy or resistance to omalizumab, and was approved by the Clinical Audit and Effectiveness team of the Hull University Teaching Hospitals NHS Trust. The health records of patients with resistant CSU who received Xolair (Omalizumab, Novartis) between the years 2017-2019 were reviewed. Omalizumab 300mg was administered subcutaneously with antihistamines every 4 weeks for 6 months, followed by an 8-week treatment interruption. In case of recurrence, further doses were approved after clinic review. Patient demographics, laboratory features (autoantibody status, IgE level, tryptase), weekly urticaria activity score (UAS7) during treatment were analysed. UAS7 at zero was considered complete remission (CR), UAS7 1-28 as partial remission (PR), UAS7>28 as non-responder (NR). Descriptive statistics including parametric and non-parametric tests were done using GraphPad Prism version 7.00 for Windows,</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7f8436b3bbede285b9c52d43d29e7673" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109491766,"asset_id":112182811,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109491766/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112182811"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112182811"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112182811; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112182811]").text(description); $(".js-view-count[data-work-id=112182811]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112182811; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112182811']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7f8436b3bbede285b9c52d43d29e7673" } } $('.js-work-strip[data-work-id=112182811]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112182811,"title":"Omalizumab retreatment rates in chronic spontaneous urticaria","internal_url":"https://www.academia.edu/112182811/Omalizumab_retreatment_rates_in_chronic_spontaneous_urticaria","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":109491766,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109491766/thumbnails/1.jpg","file_name":"letter-editorbromalizumab-retreatment-rates-chronic-spontaneous-urticaria-3687allasp1.pdf","download_url":"https://www.academia.edu/attachments/109491766/download_file","bulk_download_file_name":"Omalizumab_retreatment_rates_in_chronic.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109491766/letter-editorbromalizumab-retreatment-rates-chronic-spontaneous-urticaria-3687allasp1-libre.pdf?1703411127=\u0026response-content-disposition=attachment%3B+filename%3DOmalizumab_retreatment_rates_in_chronic.pdf\u0026Expires=1740570100\u0026Signature=aaJsRiIcINIyTNT3UZfjc48CXsJeqE2cxrZtChRTF2bg5PIss3-VbxVRdWvd7ttEYnDIJON3c2xbKpNclkU6dQ4SkO7PCDEy5xkHaVKoYS5w60qb6LWY-0vvAeVjwXu0b7ilU9KuhYWi0kwfoiwq7lXghJoX3qt1gMfd8A6ih8R8dZNofccFitcxccHkgUIwqx8x2ztPy~cZOqSdKfoXDZuSPoDzXAMjsmxX4Hs0mjVXP4o0wcXF1b8IEYSbpkpJ9u1pX-sOKemG8QAF7qYyWjzn1HhGYKFOErXI2szp~C3PfGJ5psyAeAeVDX7Hg0DweroQPiB8P5ePk8a4lO50XA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112182730"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112182730/Do_ribosomopathies_explain_some_cases_of_common_variable_immunodeficiency"><img alt="Research paper thumbnail of Do ribosomopathies explain some cases of common variable immunodeficiency?" class="work-thumbnail" src="https://attachments.academia-assets.com/109491723/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112182730/Do_ribosomopathies_explain_some_cases_of_common_variable_immunodeficiency">Do ribosomopathies explain some cases of common variable immunodeficiency?</a></div><div class="wp-workCard_item"><span>Clinical and Experimental Immunology</span><span>, Nov 9, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The considerable clinical heterogeneity of patients with common variable immunodeficiency disorde...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The considerable clinical heterogeneity of patients with common variable immunodeficiency disorders (CVID) shares some similarity with bone-marrow failure disorders such as Diamond–Blackfan anaemia (DBA) and Shwachman–Diamond syndrome (SDS), now recognized as defects in ribosome biogenesis or ribosomopathies. The recognition of a patient with DBA who subsequently developed CVID lends support to our previous finding of a heterozygous mutation in the SBDS gene of SBDS in another CVID patient, suggesting that ribosome biogenesis defects are responsible for a subset of CVID. Genetic defects in the ribosomal translational machinery responsible for various bone marrow failure syndromes are recognized readily when they manifest in children, but diagnosing these in adults presenting with complex phenotypes and hypogammaglobulinaemia can be a challenge. In this perspective paper, we discuss our clinical experience in CVID patients with ribosomopathies, and review the immunological abnormalities in other conditions associated with ribosomal dysfunction. With genetic testing available for various bone marrow failure syndromes, our hypothesis that ribosomal abnormalities may be present in patients with CVID could be proved in future studies by testing for mutations in specific ribosomal genes. New knowledge might then be translated into novel therapeutic strategies for patients in this group of immunodeficiency disorders.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a13b6d9cd46b131e00c173c58af2faf3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109491723,"asset_id":112182730,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109491723/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112182730"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112182730"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112182730; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112182730]").text(description); $(".js-view-count[data-work-id=112182730]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112182730; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112182730']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a13b6d9cd46b131e00c173c58af2faf3" } } $('.js-work-strip[data-work-id=112182730]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112182730,"title":"Do ribosomopathies explain some cases of common variable immunodeficiency?","internal_url":"https://www.academia.edu/112182730/Do_ribosomopathies_explain_some_cases_of_common_variable_immunodeficiency","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":109491723,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109491723/thumbnails/1.jpg","file_name":"j.1365-2249.2010.04280.x.pdf","download_url":"https://www.academia.edu/attachments/109491723/download_file","bulk_download_file_name":"Do_ribosomopathies_explain_some_cases_of.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109491723/j.1365-2249.2010.04280.x-libre.pdf?1703403032=\u0026response-content-disposition=attachment%3B+filename%3DDo_ribosomopathies_explain_some_cases_of.pdf\u0026Expires=1740570100\u0026Signature=FTYJnoQtr-L6mgIGGgp5diAdP-uu9jgOKOtEHuRec5imOxDoic1nthaKmG7oIWcBb9vQ4dCk4VZfpp~n8lspW6svxC4PFqWMpqBpSOxhIrxDk0bPkcXN2LIRLbQwLs4DDEsklhvsHO~96UdYDQ9S1sjUW3zqsO7kJhHrvsYQPmeOyE87i~2CeXnDvU85wQe~dm5r6V3LPSAqJykex0KTNhYEBDoTyBlO-WZdWlmG2IaQzfXi2vTHUmYIxxEnzVco4N9n6mZZPEQXPYnQnSbb0ik~YxNGRcopfIvGI6V9YxtaaNVD0yorNCSVxtxm1rgofPylSXoCt6YhaGLM3TWYsA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112182727"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112182727/Outcomes_following_SARS_CoV_2_infection_in_patients_with_primary_and_secondary_immunodeficiency_in_the_UK"><img alt="Research paper thumbnail of Outcomes following SARS-CoV-2 infection in patients with primary and secondary immunodeficiency in the UK" class="work-thumbnail" src="https://attachments.academia-assets.com/109491696/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112182727/Outcomes_following_SARS_CoV_2_infection_in_patients_with_primary_and_secondary_immunodeficiency_in_the_UK">Outcomes following SARS-CoV-2 infection in patients with primary and secondary immunodeficiency in the UK</a></div><div class="wp-workCard_item"><span>Clinical and Experimental Immunology</span><span>, Jan 28, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In March 2020, the United Kingdom Primary Immunodeficiency Network (UKPIN) established a registry...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In March 2020, the United Kingdom Primary Immunodeficiency Network (UKPIN) established a registry of cases to collate the outcomes of individuals with PID and SID following SARS-CoV-2 infection and treatment. A total of 310 cases of SARS-CoV-2 infection in individuals with PID or SID have now been reported in the UK. The overall mortality within the cohort was 17.7% (n = 55/310). Individuals with CVID demonstrated an infection fatality rate (IFR) of 18.3% (n = 17/93), individuals with PID receiving IgRT had an IFR of 16.3% (n = 26/159) and individuals with SID, an IFR of 27.2% (n = 25/92). Individuals with PID and SID had higher inpatient mortality and died at a younger age than the general population. Increasing age, low pre-SARS-CoV-2 infection lymphocyte count and the presence of common co-morbidities increased the risk of mortality in PID. Access to specific COVID-19 treatments in this cohort was limited: only 22.9% (n = 33/144) of patients admitted to the hospital received dexamethasone, remdesivir, an anti-SARS-CoV-2 antibody-based therapeutic (e.g. REGN-COV2 or convalescent plasma) or tocilizumab as a monotherapy or in combination. Dexamethasone, remdesivir, and anti-SARS-CoV-2 antibody-based therapeutics appeared efficacious in PID and SID. Compared to the general population, individuals with PID or SID are at high risk of mortality following SARS-CoV-2 infection. Increasing age, low baseline lymphocyte count, and the presence of co-morbidities are additional risk factors for poor outcome in this cohort.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9f12160557f06ed18eb1b80048e015f3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109491696,"asset_id":112182727,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109491696/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112182727"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112182727"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112182727; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112182727]").text(description); $(".js-view-count[data-work-id=112182727]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112182727; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112182727']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9f12160557f06ed18eb1b80048e015f3" } } $('.js-work-strip[data-work-id=112182727]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112182727,"title":"Outcomes following SARS-CoV-2 infection in patients with primary and secondary immunodeficiency in the UK","internal_url":"https://www.academia.edu/112182727/Outcomes_following_SARS_CoV_2_infection_in_patients_with_primary_and_secondary_immunodeficiency_in_the_UK","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":109491696,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109491696/thumbnails/1.jpg","file_name":"uxac008.pdf","download_url":"https://www.academia.edu/attachments/109491696/download_file","bulk_download_file_name":"Outcomes_following_SARS_CoV_2_infection.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109491696/uxac008-libre.pdf?1703403036=\u0026response-content-disposition=attachment%3B+filename%3DOutcomes_following_SARS_CoV_2_infection.pdf\u0026Expires=1740570100\u0026Signature=RjRdYV66weSO6ajAOPANeOJm0qTtXZ4ZIENhSidUlFhHOTZGjw94K4o5jYGpiNZGRsmJ-unTd5oriqWX57Er4SvA1y8dZx0~ZqUv16W7h8yRS~AFHsiF1Q~jXHzXrfUjTb5sE1657j9tGnR846WLdh~CM7P~yhKVVnnpKSUbMU34EBXyhxVppppHByV6CyPjQRNt1MeItEofulksDzxTPH3YjzASXMoMgvUVB2vWSz1sKuga~Bf0h8hPX09ZoSBDeUjSoadayC6JkqCy9sLxRUMQ2FV15FqzfUOhzVGMaeThS7cm8iNBL1P4o4ofr3XKq7fJ82FURT~cDMYaBvrthg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":109491695,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109491695/thumbnails/1.jpg","file_name":"uxac008.pdf","download_url":"https://www.academia.edu/attachments/109491695/download_file","bulk_download_file_name":"Outcomes_following_SARS_CoV_2_infection.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109491695/uxac008-libre.pdf?1703403038=\u0026response-content-disposition=attachment%3B+filename%3DOutcomes_following_SARS_CoV_2_infection.pdf\u0026Expires=1740570100\u0026Signature=dEXPLs-bNkm~71k1muzLpRtVzblvs2oYPIbpMla65vL9dXTTUWJmsjly25mWjszPI3uS1NDqqH8san2yoUSo8hVTeZjxugTNzbULn7V5vx~iHyGJJs8-1OPugndpH2sgq1kTc18Txh2OH838AtU4n0yCVWyigrXtBlInDybJ-wDw07I7MMref7O8haWhhzbRxoa5-GVsXD-ci81DwX5TiNYVKHGtDjlinjJl8miKjx-AME1T5I8Yr5Z3lVbV9cx0q5uaw7A3BKdTvIlj6B1~bGc2WxnuZ2zb16VRj8Yn9~KGukkc74-ndyR0BBEsObIw4XRuhLdDR~WdajeiD5H~1A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112182723"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112182723/Aspergillus_fumigatus_IgG_level_greater_than_60_mg_L_Increases_Diagnostic_Specificity_of_Allergic_Bronchopulmonary_Aspergillosis"><img alt="Research paper thumbnail of Aspergillus fumigatus IgG level greater than 60 mg/L Increases Diagnostic Specificity of Allergic Bronchopulmonary Aspergillosis" class="work-thumbnail" src="https://attachments.academia-assets.com/109491719/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112182723/Aspergillus_fumigatus_IgG_level_greater_than_60_mg_L_Increases_Diagnostic_Specificity_of_Allergic_Bronchopulmonary_Aspergillosis">Aspergillus fumigatus IgG level greater than 60 mg/L Increases Diagnostic Specificity of Allergic Bronchopulmonary Aspergillosis</a></div><div class="wp-workCard_item"><span>The Journal of Allergy and Clinical Immunology</span><span>, Feb 1, 2018</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="443ed2e0a36db5eba2592e23110764ad" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109491719,"asset_id":112182723,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109491719/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112182723"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112182723"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112182723; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112182723]").text(description); $(".js-view-count[data-work-id=112182723]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112182723; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112182723']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "443ed2e0a36db5eba2592e23110764ad" } } $('.js-work-strip[data-work-id=112182723]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112182723,"title":"Aspergillus fumigatus IgG level greater than 60 mg/L Increases Diagnostic Specificity of Allergic Bronchopulmonary Aspergillosis","internal_url":"https://www.academia.edu/112182723/Aspergillus_fumigatus_IgG_level_greater_than_60_mg_L_Increases_Diagnostic_Specificity_of_Allergic_Bronchopulmonary_Aspergillosis","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":109491719,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109491719/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/109491719/download_file","bulk_download_file_name":"Aspergillus_fumigatus_IgG_level_greater.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109491719/pdf-libre.pdf?1703403029=\u0026response-content-disposition=attachment%3B+filename%3DAspergillus_fumigatus_IgG_level_greater.pdf\u0026Expires=1740570100\u0026Signature=IOuzush9~ghmJ2Nxb5o9wl7PmFlW~vK9hFd-h~PPS2DJMhWnnzfD~txcatoU8LDZWfWdSx7xwjCD1HQIfLGjaETkeKGuMb2OzRAe9plHepW1a8VfipBuOrvwarwCXFZIuslfkHYW-Qf74WMEXLtRceUobN3ZbibT4O1mgzQiML3F-eehmDFFYRV15DyzNJB3NQKO2WblcKABZe7ICiP~YoSrgstktHJNxM07kIDmtF5TOtaZNV57ZbSEkqcBilExjBJEPNHKbsZieeyBihjdV-dMT4GO~h2mD8vUUHDf273XGsVxLRYPS0~EYtVgUL9PIihpQjP8Yfpwr7mQ5X5KYg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="112182720"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/112182720/Impact_of_vaccination_on_hospitalization_and_mortality_from_COVID_19_in_patients_with_primary_and_secondary_immunodeficiency_The_United_Kingdom_experience"><img alt="Research paper thumbnail of Impact of vaccination on hospitalization and mortality from COVID-19 in patients with primary and secondary immunodeficiency: The United Kingdom experience" class="work-thumbnail" src="https://attachments.academia-assets.com/109491720/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/112182720/Impact_of_vaccination_on_hospitalization_and_mortality_from_COVID_19_in_patients_with_primary_and_secondary_immunodeficiency_The_United_Kingdom_experience">Impact of vaccination on hospitalization and mortality from COVID-19 in patients with primary and secondary immunodeficiency: The United Kingdom experience</a></div><div class="wp-workCard_item"><span>Frontiers in Immunology</span><span>, Sep 23, 2022</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Individuals with primary and secondary immunodeficiency (PID/SID) were shown to be at...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Individuals with primary and secondary immunodeficiency (PID/SID) were shown to be at risk of poor outcomes during the early stages of the SARS-CoV-2 pandemic. SARS-CoV-2 vaccines demonstrate reduced immunogenicity in these patients. Objectives: To understand whether the risk of severe COVID-19 in individuals with PID or SID has changed following the deployment of vaccination and therapeutics in the context of the emergence of novel viral variants of concern.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="75990bc2da6660100f3616b1318b9992" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":109491720,"asset_id":112182720,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/109491720/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="112182720"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="112182720"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 112182720; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=112182720]").text(description); $(".js-view-count[data-work-id=112182720]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 112182720; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='112182720']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "75990bc2da6660100f3616b1318b9992" } } $('.js-work-strip[data-work-id=112182720]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":112182720,"title":"Impact of vaccination on hospitalization and mortality from COVID-19 in patients with primary and secondary immunodeficiency: The United Kingdom experience","internal_url":"https://www.academia.edu/112182720/Impact_of_vaccination_on_hospitalization_and_mortality_from_COVID_19_in_patients_with_primary_and_secondary_immunodeficiency_The_United_Kingdom_experience","owner_id":26980189,"coauthors_can_edit":true,"owner":{"id":26980189,"first_name":"Sujoy","middle_initials":"","last_name":"Khan","page_name":"SujoyKhan","domain_name":"independent","created_at":"2015-02-28T20:41:54.192-08:00","display_name":"Sujoy Khan","url":"https://independent.academia.edu/SujoyKhan"},"attachments":[{"id":109491720,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/109491720/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/109491720/download_file","bulk_download_file_name":"Impact_of_vaccination_on_hospitalization.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/109491720/pdf-libre.pdf?1703403030=\u0026response-content-disposition=attachment%3B+filename%3DImpact_of_vaccination_on_hospitalization.pdf\u0026Expires=1740570100\u0026Signature=buYbAfRbHv8g4HGT3wqcaI06G6dk0MWiy9~ej2fOexVgn-LXvVM7Npmrw2xRnhENRjORS-2HFI8M0UY8lUfTERomlMaY-1ophazJ7cHGvWXPOVrClvIgKeDpk4bKlfD3xfQ9CLz4yMWrlIs3mSBk9ZeAQhQdLdwb-Mt3gsnKjtAjnGaRc4gDbwyy1u6tccdZpfbDeOWloB4dQsYP9eOh4wDjGwBtLcoW5CqrzmSsH6e87u-BrZSENTq1qH5jO22F3eNMWSCamCmrkdyAqhmNRaKr8y6dYdWssigzgGz~0kmNmTNl~S82GtLcSfuZdBFNjBrFc7DcX7fb~JuIQHD0pg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/google_contacts-0dfb882d836b94dbcb4a2d123d6933fc9533eda5be911641f20b4eb428429600.js"], function() { // from javascript_helper.rb $('.js-google-connect-button').click(function(e) { e.preventDefault(); GoogleContacts.authorize_and_show_contacts(); Aedu.Dismissibles.recordClickthrough("WowProfileImportContactsPrompt"); }); $('.js-update-biography-button').click(function(e) { e.preventDefault(); Aedu.Dismissibles.recordClickthrough("UpdateUserBiographyPrompt"); $.ajax({ url: $r.api_v0_profiles_update_about_path({ subdomain_param: 'api', about: "", }), type: 'PUT', success: function(response) { location.reload(); } }); }); $('.js-work-creator-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_document_path({ source: encodeURIComponent(""), }); }); $('.js-video-upload-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_video_path({ source: encodeURIComponent(""), }); }); $('.js-do-this-later-button').click(function() { $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("WowProfileImportContactsPrompt"); }); $('.js-update-biography-do-this-later-button').click(function(){ $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("UpdateUserBiographyPrompt"); }); $('.wow-profile-mentions-upsell--close').click(function(){ $('.wow-profile-mentions-upsell--panel').hide(); Aedu.Dismissibles.recordDismissal("WowProfileMentionsUpsell"); }); $('.wow-profile-mentions-upsell--button').click(function(){ Aedu.Dismissibles.recordClickthrough("WowProfileMentionsUpsell"); }); new WowProfile.SocialRedesignUserWorks({ initialWorksOffset: 20, allWorksOffset: 20, maxSections: 1 }) }); </script> </div></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile_edit-5ea339ee107c863779f560dd7275595239fed73f1a13d279d2b599a28c0ecd33.js","https://a.academia-assets.com/assets/add_coauthor-22174b608f9cb871d03443cafa7feac496fb50d7df2d66a53f5ee3c04ba67f53.js","https://a.academia-assets.com/assets/tab-dcac0130902f0cc2d8cb403714dd47454f11fc6fb0e99ae6a0827b06613abc20.js","https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js"], function() { // from javascript_helper.rb window.ae = window.ae || {}; window.ae.WowProfile = window.ae.WowProfile || {}; if(Aedu.User.current && Aedu.User.current.id === $viewedUser.id) { window.ae.WowProfile.current_user_edit = {}; new WowProfileEdit.EditUploadView({ el: '.js-edit-upload-button-wrapper', model: window.$current_user, }); new AddCoauthor.AddCoauthorsController(); } var userInfoView = new WowProfile.SocialRedesignUserInfo({ recaptcha_key: "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB" }); WowProfile.router = new WowProfile.Router({ userInfoView: userInfoView }); Backbone.history.start({ pushState: true, root: "/" + $viewedUser.page_name }); new WowProfile.UserWorksNav() }); </script> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; } .sign-in-with-apple-button > div { margin: 0 auto; / This centers the Apple-rendered button horizontally }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "05373e3e95de37f005560537c34aecf2596894cf25004182d48a1c350eefcffc", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input type="hidden" name="authenticity_token" value="HmtFWuWdvQIGlvPYeLl96UStKTfZAr2fkFZJAUgvbMpfgOMB1CXcPhN6TjzlARcJ4qL9bJWL37jx0SjLKvBIsw" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://independent.academia.edu/SujoyKhan" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input type="hidden" name="authenticity_token" value="m_YFU1EU26lSbZcjXkn-Us4ByRMWyArPiZoFP0dJdW_aHaMIYKy6lUeBKsfD8ZSyaA4dSFpBaOjoHWT1JZZRFg" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style="width:100%;"><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/hc/en-us"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style="width:100%;"><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2025</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>