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Articles (6)</a>   <span>Subscriber (50764)</span> </div> </div> </div> </div> <script type="text/javascript"> $(function () { try { InitializeResultAnalysisBtn(); InitAllFacetRefineContainers(); var sort = getQueryString2('sort'); if (sort != null && sort != '') { $("[field='st" + sort + "']").addClass("sort-highlight"); } } catch (e) { } }); </script> <input type="hidden" name="ctl00$RootHolder$pageName" id="pageName" value="citearticles" /> <div class="search-result-container cl"> <div class="search-centered cl"> <div class="search-result-center-container cl"> <div class="left-part"> <div class="mnavbar"> <table class="total-count-container cl"> <tr> <td> Citation(s) in <i>RCA</i> </td> </tr> </table> </div> <div class="mnavbox"> <label id="RootHolder_TotalCountText" class="total-count-text">151</label><br /> <label style="font-size:14px;">(from Reference Citation Analysis)</label> </div> <div class="mnavbar"> <div> Indexed Articles </div> </div> <div class="mnavbox"> <ul class="ul sortedby-list"> <li> <a href="javascript:SubmitSingleFacetSearch('published','6');" id="RootHolder_todayCount">Today (0)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('published','5');" id="RootHolder_yesterdayCount">Yesterday (0)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('published','4');" id="RootHolder_thisWeekCount">This Week (1)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('published','3');" id="RootHolder_lastWeekCount">Last Week (2)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('published','2');" id="RootHolder_currentMonthCount">Current Month (3)</a> </li> <li> <a href="javascript:SubmitSingleFacetSearch('published','1');" id="RootHolder_lastMonthCount">Last Month (1)</a> </li> </ul> </div> <div class="mnavbar"> <div> Ranked By </div> </div> <div class="mnavbox"> <ul class="ul sortedby-list"> <li> <a href="javascript:void(0);" name="sortedby" onclick="SetSorted('ai')" id="aisorted">Impact Index Per Article</a> </li> <li> <a href="javascript:void(0);" name="sortedby" onclick="SetSorted('citedf6')" id="citedf6sorted"> Citation(s) in <i>RCA</i> </a> </li> </ul> </div> <div id="RootHolder_ResultsAnalysisContainer"> <div class="mnavbar"> <div> Results Analysis </div> </div> <div class="mnavbox"> <ul class="ul analysis-list"> <li> <input type="checkbox" id="YearAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="year" />  <label for="YearAnalysis">Year Published Analysis</label> </li> <li> <input type="checkbox" id="ArticleTypeAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="at" />  <label for="ArticleTypeAnalysis">Article Type Analysis</label> </li> <li> <input type="checkbox" id="JournalTitleAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="journal" />  <label for="JournalTitleAnalysis">Journal Title Analysis</label> </li> <li> <input type="checkbox" id="CategoriesAnalysis" onclick="InitializeResultAnalysisBtn();" name="analysis-check" value="subject" />  <label for="CategoriesAnalysis">Category Analysis</label> </li> </ul> <div class="refine-btn-container cl" name="analysis-check-btn-container"> <a href="javascript:ResultAnalysis();" class="refine-link-btn refine-link-btn-right" target="_self">Results Analysis</a> </div> </div> </div> <div id="RootHolder_YearFacetContainer"> <div class="mnavbar"> <div> Year Published </div> </div> <div class="mnavbox"> <ul class="ul facet-items cl" id="yearcheckcontainer1"> <li> <input type="checkbox" id="yearcheck1" checktype="facet-check" name="yearcheck" value="2024" class="facet-item-checkbox" /> </li> <li> <a href="javascript:SubmitSingleClickFacetSearch('year','yearcheck1');" target="_self"> <label>2024 (14)</label> </a> </li> </ul> <ul class="ul facet-items cl" id="yearcheckcontainer2"> <li> <input type="checkbox" id="yearcheck2" checktype="facet-check" name="yearcheck" value="2023" class="facet-item-checkbox" /> </li> <li> <a href="javascript:SubmitSingleClickFacetSearch('year','yearcheck2');" target="_self"> <label>2023 (21)</label> </a> </li> </ul> <ul class="ul facet-items cl" id="yearcheckcontainer3"> <li> <input type="checkbox" id="yearcheck3" checktype="facet-check" name="yearcheck" value="2022" class="facet-item-checkbox" /> </li> <li> <a href="javascript:SubmitSingleClickFacetSearch('year','yearcheck3');" target="_self"> <label>2022 (28)</label> </a> </li> </ul> <ul class="ul facet-items cl" id="yearcheckcontainer4"> <li> <input type="checkbox" id="yearcheck4" checktype="facet-check" name="yearcheck" value="2021" class="facet-item-checkbox" /> </li> <li> <a href="javascript:SubmitSingleClickFacetSearch('year','yearcheck4');" target="_self"> <label>2021 (42)</label> </a> </li> </ul> <ul class="ul facet-items cl" id="yearcheckcontainer5"> <li> <input type="checkbox" id="yearcheck5" checktype="facet-check" name="yearcheck" value="2020" class="facet-item-checkbox" /> </li> <li> <a href="javascript:SubmitSingleClickFacetSearch('year','yearcheck5');" target="_self"> <label>2020 (26)</label> </a> </li> </ul> <ul class="ul facet-items cl" id="yearcheckcontainer6"> <li> <input type="checkbox" id="yearcheck6" checktype="facet-check" name="yearcheck" value="2019" class="facet-item-checkbox" /> </li> <li> <a href="javascript:SubmitSingleClickFacetSearch('year','yearcheck6');" target="_self"> <label>2019 (19)</label> </a> </li> </ul> <ul class="ul facet-items cl" id="yearcheckcontainer7"> <li> <input type="checkbox" id="yearcheck7" checktype="facet-check" name="yearcheck" value="2018" class="facet-item-checkbox" /> </li> <li> <a href="javascript:SubmitSingleClickFacetSearch('year','yearcheck7');" target="_self"> <label>2018 (1)</label> </a> </li> </ul> <div class="refine-btn-container cl"> <a href="javascript:ShowResultItems('year');" class="refine-link-btn" target="_self">Show more</a>   <a href="javascript:SubmitFacetSearch();" class="refine-link-btn refine-link-btn-right" name="refineyearcheck" target="_self">Refine</a> </div> </div> </div> <div id="RootHolder_JournalSourceFacetContainer"> <div class="mnavbar"> <div> Article Statistics </div> </div> <div class="mnavbox"> <table class="ul facet-items-table cl" id="jscheckcontainer1"> <tr> <td> <input type="checkbox" id="js1" checktype="facet-check" class="facet-item-checkbox" name="jscheck" value="PubMed" /> </td> <td> <a href="javascript:SubmitSingleClickFacetSearch('js','js1');" target="_self"> <label>PubMed (138)</label> </a> </td> </tr> </table> <table class="ul facet-items-table cl" id="jscheckcontainer2"> <tr> <td> <input type="checkbox" id="js2" checktype="facet-check" class="facet-item-checkbox" name="jscheck" value="SCIE" /> </td> <td> <a href="javascript:SubmitSingleClickFacetSearch('js','js2');" target="_self"> <label>SCIE (138)</label> </a> </td> </tr> </table> <table class="ul facet-items-table cl" id="jscheckcontainer3"> <tr> <td> <input type="checkbox" id="js3" checktype="facet-check" class="facet-item-checkbox" name="jscheck" value="RCA" /> </td> <td> <a href="javascript:SubmitSingleClickFacetSearch('js','js3');" target="_self"> <label>RCA (125)</label> </a> </td> </tr> </table> <table class="ul facet-items-table cl" id="jscheckcontainer4"> <tr> <td> <input type="checkbox" id="js4" checktype="facet-check" class="facet-item-checkbox" name="jscheck" value="Open" /> </td> <td> <a href="javascript:SubmitSingleClickFacetSearch('js','js4');" target="_self"> <label>Open (101)</label> </a> </td> </tr> </table> <table class="ul facet-items-table cl" id="jscheckcontainer5"> <tr> <td> <input type="checkbox" id="js5" checktype="facet-check" class="facet-item-checkbox" name="jscheck" value="ESCI" /> </td> <td> <a href="javascript:SubmitSingleClickFacetSearch('js','js5');" target="_self"> <label>ESCI (1)</label> </a> </td> </tr> </table> <div class="refine-btn-container cl" name="refinejscheck"> <a href="javascript:SubmitFacetSearch();" 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class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NumberTitle">Number</span></td> <td><span class="dxeBase_MetropolisBlue" id="RootHolder_SearchResultList_NameTitle">Cited by Other Article(s)</span></td> </tr> </thead> <tbody> <tr id="articlerow1"> <td style="min-width:40px;text-align:center;"> 1 </td> <td> <div id="citation1" class="article-citation"> <b>Jia Y</b>, Liu M, Liu H, Liang W, Zhu Q, Wang C, Chen Y, Gao Y, Liu Z, Cheng X. <i>DSN1</i> may predict poor prognosis of lower-grade glioma patients and be a potential target for immunotherapy. <em class='incite-journal-name' onclick='ShowInCiteJournal(4396);'>Cancer Biol Ther</em> 2024;<b>25</b>:2425134. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39555702' target='_blank'>39555702</a> DOI: <a href='https://dx.doi.org/10.1080/15384047.2024.2425134' target='_blank'>10.1080/15384047.2024.2425134</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1080/15384047.2024.2425134','39555702', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(1);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(1);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(1);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1080/15384047.2024.2425134' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4396);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/16/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/11/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/30/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/19/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.1080/15384047.2024.2425134" /> <div style="display:none" id="articleAbstract1" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">DSN1 has been previously found to be positively correlated with various cancers. However, the effect of DSN1 or its methylation on the prognosis, molecular characteristics, and immune cell infiltration of low-grade glioma (LGG) has not yet been studied. We obtained 1046 LGG samples from the The Cancer Genome Atlas, The Chinese Glioma Genome Atlas (CGGA) microarray, and CGGA RNA-Seq databases. Bioinformatic methods (gene set enrichment analysis (GSEA), chi-square test, multivariate), and laboratory validation were used to investigate DSN1 in LGG. The expression levels of DSN1 mRNA and protein in LGG were substantially higher than those in normal brain tissue, and their expression was negatively regulated by methylation. The survival time of patients with low expression of DSN1 and cg12601032 hypermethylation was considerably prolonged. DSN1 was a risk factor, and of good diagnostic and prognostic value for LGG. Importantly, the expression of DSN1 is related to many types of tumor-infiltrating immune cells and has a positive correlation with PDL1. DSN1 promoted the activation of multiple cancer-related pathways, such as the cell cycle. Additionally, knockdown of DSN1 substantially inhibited the proliferation and invasion of LGG cells. To the best of our knowledge, this study is the first comprehensive analysis of the mechanism of DSN1 leading to poor prognosis of LGG, which provides a new perspective for revealing the pathogenesis of LGG. DSN1 or its methylation has diagnostic value for the prognosis of glioma, and may become a new biological target of anti-tumor immunotherapy. </div> <a href="javascript:ShowArticleAbstract(1);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords1" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DSN1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DSN1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Low-grade+glioma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Low-grade glioma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22biomarker%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" 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target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant1" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(1);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors1" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yulong+Jia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yulong Jia</a></li><ul><li>Department of Neurosurgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, School of Clinical Medicine, Henan University, Zhengzhou, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Meiling+Liu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Meiling Liu</a></li><ul><li>School of Clinical Medicine, Sanquan College of Xinxiang Medical University, Xinxiang, Henan, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Han+Liu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Han Liu</a></li><ul><li>Department of Clinical Medicine, Medical College of Jinzhou Medical University. Taihe District, Jinzhou, Liaoning Province, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wenjia+Liang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wenjia Liang</a></li><ul><li>Henan Provincial People's Hospital, People's Hospital of Henan University, Zhengzhou, Henan Province, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Qingyun+Zhu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Qingyun Zhu</a></li><ul><li>Henan Provincial People's Hospital, People's Hospital of Henan University, Zhengzhou, Henan Province, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chao+Wang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chao Wang</a></li><ul><li>Department of Neurobiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, Heilongjiang, P. R. China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yake+Chen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yake Chen</a></li><ul><li>School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yanzheng+Gao%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yanzheng Gao</a></li><ul><li>Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, Henan Province Intelligent orthopedic technology innovation and transformation International Joint Laboratory, Henan Key Laboratory for intelligent precision orthopedics, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zhendong+Liu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zhendong Liu</a></li><ul><li>Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, Henan Province Intelligent orthopedic technology innovation and transformation International Joint Laboratory, Henan Key Laboratory for intelligent precision orthopedics, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xingbo+Cheng%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xingbo Cheng</a></li><ul><li>Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, Henan Province Intelligent orthopedic technology innovation and transformation International Joint Laboratory, Henan Key Laboratory for intelligent precision orthopedics, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, China<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(1);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow2"> <td style="min-width:40px;text-align:center;"> 2 </td> <td> <div id="citation2" class="article-citation"> <b>Wu X</b>, Shen T, Ji W, Huang M, Sima J, Li J, Song H, Xiong W, Cen M. lncRNA CASC11 regulates the progress of delayed fracture healing via sponging miR-150-3p. <em class='incite-journal-name' onclick='ShowInCiteJournal(14821);'>J Orthop Surg Res</em> 2024;<b>19</b>:757. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39543626' target='_blank'>39543626</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562309' target='_blank'>PMC11562309</a> DOI: <a href='https://dx.doi.org/10.1186/s13018-024-05226-5' target='_blank'>10.1186/s13018-024-05226-5</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s13018-024-05226-5','39543626', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(2);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(2);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(2);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s13018-024-05226-5' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14821);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://submission.nature.com/new-submission/13018/3' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/17/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.1186/s13018-024-05226-5" /> <div style="display:none" id="articleAbstract2" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Long non-coding RNA (lncRNA) plays a pivotal role in bone regeneration by interaction with microRNAs (miRNAs) and constructing a lncRNA-miRNA regulatory network. </div><div class="abstract-label">OBJECTIVES</div><div class="abstract-content">This research aimed to elucidate the role of lncRNA CASC11 in the delayed healing process of tibial fractures and to explore its potential regulatory mechanisms. </div><div class="abstract-label">MATERIALS AND METHODS</div><div class="abstract-content">The expression levels of CASC11 and miR-150-3p in serum samples were detected and the predictive capability of CASC11 regarding delayed healing in fracture patients. Furthermore, the study confirmed the accuracy of the binding sites between CASC11 and miR-150-3p. Subsequently, overexpression/interference plasmids of CASC11, along with overexpression plasmids co-transfected with both CASC11 and miR-150-3p, were systematically introduced into MC3T3-E1 cells to investigate their effects on the expression of osteogenic marker genes, as well as their influence on cellular proliferation and apoptosis. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">The expression levels of CASC11 were significantly elevated, while miR-150-3p levels were markedly decreased in individuals exhibiting delayed fracture healing (P < 0.001). CASC11 was observed to suppress the expression of osteogenic marker genes, inhibit the proliferation of MC3T3-E1 cells, and promote cell apoptosis (P < 0.05). Furthermore, the overexpression of miR-150-3p effectively countered the inhibitory impact of CASC11 on osteogenic differentiation and the promoting effect on cell apoptosis (P < 0.05). </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">The sponging effect of CASC11 on miR-150-3p led to delayed fracture healing. CASC11 emerges as a potential target for treating delayed fracture healing. </div> <a href="javascript:ShowArticleAbstract(2);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords2" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Delayed+fracture+healing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Delayed fracture healing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22LncRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LncRNA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenic+differentiation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenic differentiation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22miRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">miRNA</a></li></ul> <a href="javascript:ShowArticleKeywords(2);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh2" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fracture+Healing%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fracture Healing/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fracture+Healing%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fracture Healing/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Male%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Male</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tibial+Fractures%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tibial Fractures/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Female%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Female</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Apoptosis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Apoptosis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Osteogenesis%2fphysiology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Osteogenesis/physiology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Adult%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Adult</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Middle+Aged%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Middle Aged</a></li></ul> <a href="javascript:ShowArticleMeSH(2);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant2" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(2);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors2" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xiaoming+Wu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xiaoming Wu</a></li><ul><li>Orthopedics, Affiliated Hospital of Hebei University, Baoding, 071000, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tuwang+Shen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tuwang Shen</a></li><ul><li>Operating Room, North China University of Science and Technology Affiliated Hospital, Tangshan, 063000, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wenjun+Ji%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wenjun Ji</a></li><ul><li>Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, No. 149, Dalian Road, Huichuan District, Zunyi City, Guizhou Province, 563000, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Miao+Huang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Miao Huang</a></li><ul><li>Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, No. 149, Dalian Road, Huichuan District, Zunyi City, Guizhou Province, 563000, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jincheng+Sima%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jincheng Sima</a></li><ul><li>Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, No. 149, Dalian Road, Huichuan District, Zunyi City, Guizhou Province, 563000, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jin+Li%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jin Li</a></li><ul><li>Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, No. 149, Dalian Road, Huichuan District, Zunyi City, Guizhou Province, 563000, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hao+Song%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hao Song</a></li><ul><li>Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, No. 149, Dalian Road, Huichuan District, Zunyi City, Guizhou Province, 563000, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wei+Xiong%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wei Xiong</a></li><ul><li>Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, No. 149, Dalian Road, Huichuan District, Zunyi City, Guizhou Province, 563000, China.<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Meini+Cen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Meini Cen</a></li><ul><li>Department of Rehabilitation Medicine, The Affiliated Hospital of Youjiang Medical University for Nationalities, No.18, Zhongshan 2nd Road, Youjiang District, Baise, Guangxi, 533000, China.<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(2);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow3"> <td style="min-width:40px;text-align:center;"> 3 </td> <td> <div id="citation3" class="article-citation"> <b>Wang H</b>, Li C, Meng S, Kuang YT. The LINC01094/miR-545-3p/SLC7A11 Signaling Axis Promotes the Development of Gastric Cancer by Regulating Cell Growth and Ferroptosis. <em class='incite-journal-name' onclick='ShowInCiteJournal(3278);'>Biochem Genet</em> 2024:10.1007/s10528-024-10959-3. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39540959' target='_blank'>39540959</a> DOI: <a href='https://dx.doi.org/10.1007/s10528-024-10959-3' target='_blank'>10.1007/s10528-024-10959-3</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s10528-024-10959-3','39540959', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(3);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(3);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s10528-024-10959-3' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3278);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/23/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/26/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2024]</span></span> </div> <input type="hidden" value="10.1007/s10528-024-10959-3" /> <div style="display:none" id="articleAbstract3" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">This study aimed to investigate the role and mechanism of action of LINC01094 in the development of gastric cancer (GC). The expression levels of LINC01094 in GC patients and healthy individuals were analyzed online using the Cancer Genome Atlas database. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot analyses were performed to determine the expression of LINC01094/miR-545-3p/SLC7A11 in GC tissues and cells. Functional experiments (MTT assay, colony formation assay, and flow cytometry) were conducted to assess the effect of LINC01094 and miR-545-3p on cell proliferation, viability, apoptosis, cell cycle, and reactive oxygen species. Correlations between LINC01094 and miR-545-3p, as well as SLC7A11, were analyzed and validated using the dual-luciferase reporter assay and RNA immunoprecipitation. The levels of Fe2+, malondialdehyde, and glutathione in the cells were measured biochemically, and the protein expression levels of Bcl-2, cleaved caspase3, Cyclin D1, and p21 were detected by Western blotting. LINC01094 was significantly upregulated in the GC tissues and cells with a targeting relationship with miR-545-3p; the expression levels of LINC01094 and miR-545-3p were negatively correlated. Knockdown of LINC01094 notably inhibited the proliferation and viability of GC cells and promoted cell ferroptosis, which, however, was abrogated by the silencing of miR-545-3p. These findings indicate that miR-545-3p could target and positively correlate with SLC7A11 expression. Additionally, LINC01094 could promote GC cell progression and affect cellular ferroptosis by regulating the miR-545-3p/SLC7A11 signaling axis. </div> <a href="javascript:ShowArticleAbstract(3);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords3" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ferroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ferroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastric+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastric cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22LINC01094%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LINC01094</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SLC7A11%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SLC7A11</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22miR-545-3p%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">miR-545-3p</a></li></ul> <a href="javascript:ShowArticleKeywords(3);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh3" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(3);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant3" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(3);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors3" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hui+Wang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hui Wang</a></li><ul><li>Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, China<li><li>Department of Gastrointestinal Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chao+Li%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chao Li</a></li><ul><li>Department of Gastrointestinal Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Song+Meng%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Song Meng</a></li><ul><li>Department of Gastrointestinal Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, Jiangsu, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yu-Ting+Kuang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yu-Ting Kuang</a></li><ul><li>Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, China.<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(3);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow4"> <td style="min-width:40px;text-align:center;"> 4 </td> <td> <div id="citation4" class="article-citation"> <b>Biswal S</b>, Mallick B. Unlocking the potential of signature-based drug repurposing for anticancer drug discovery. <em class='incite-journal-name' onclick='ShowInCiteJournal(2717);'>Arch Biochem Biophys</em> 2024;<b>761</b>:110150. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39265695' target='_blank'>39265695</a> DOI: <a href='https://dx.doi.org/10.1016/j.abb.2024.110150' target='_blank'>10.1016/j.abb.2024.110150</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.abb.2024.110150','39265695', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(4);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(4);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(4);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.abb.2024.110150' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(2717);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/01/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/14/2024]</span></span> </div> <input type="hidden" value="10.1016/j.abb.2024.110150" /> <div style="display:none" id="articleAbstract4" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Cancer is the leading cause of death worldwide and is often associated with tumor relapse even after chemotherapeutics. This reveals malignancy is a complex process, and high-throughput omics strategies in recent years have contributed significantly in decoding the molecular mechanisms of these complex events in cancer. Further, the omics studies yield a large volume of cancer-specific molecular signatures that promote the discovery of cancer therapy drugs by a method termed signature-based drug repurposing. The drug repurposing method identifies new uses for approved drugs beyond their intended initial therapeutic use, and there are several approaches to it. In this review, we discuss signature-based drug repurposing in cancer, how cancer omics have revolutionized this method of drug discovery, and how one can use the cancer signature data for repurposed drug identification by providing a step-by-step procedural handout. This modern approach maximizes the use of existing therapeutic agents for cancer therapy or combination therapy to overcome chemotherapeutics resistance, making it a pragmatic and efficient alternative to traditional resource-intensive and time-consuming methods. </div> <a href="javascript:ShowArticleAbstract(4);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords4" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anticancer+drug%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anticancer drug</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+repurposing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug repurposing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+signature%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene signature</a></li></ul> <a href="javascript:ShowArticleKeywords(4);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh4" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Repositioning%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Repositioning/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antineoplastic+Agents%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antineoplastic Agents/pharmacology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antineoplastic+Agents%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antineoplastic Agents/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antineoplastic+Agents%2fchemistry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antineoplastic Agents/chemistry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Discovery%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Discovery/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li></ul> <a href="javascript:ShowArticleMeSH(4);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant4" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(4);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors4" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sruti+Biswal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sruti Biswal</a></li><ul><li>RNAi and Functional Genomics Lab., Department of Life Science, National Institute of Technology Rourkela, Rourkela, 769008, Odisha, India<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bibekanand+Mallick%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bibekanand Mallick</a></li><ul><li>RNAi and Functional Genomics Lab., Department of Life Science, National Institute of Technology Rourkela, Rourkela, 769008, Odisha, India.<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(4);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow5"> <td style="min-width:40px;text-align:center;"> 5 </td> <td> <div id="citation5" class="article-citation"> <b>Wu Y</b>, Guo X, Jin L, Huang G, Niu L, Zhao Y. Lnc-LINC00511 promotes gastric cancer progression by regulating MiR-29c-3p/TRIP13 axis through AKT/mTOR pathway. <em class='incite-journal-name' onclick='ShowInCiteJournal(11467);'>Int J Biol Macromol</em> 2024;<b>281</b>:136455. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39389496' target='_blank'>39389496</a> DOI: <a href='https://dx.doi.org/10.1016/j.ijbiomac.2024.136455' target='_blank'>10.1016/j.ijbiomac.2024.136455</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.ijbiomac.2024.136455','39389496', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(5);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(5);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(5);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.ijbiomac.2024.136455' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11467);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/17/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/18/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/07/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/12/2024]</span></span> </div> <input type="hidden" value="10.1016/j.ijbiomac.2024.136455" /> <div style="display:none" id="articleAbstract5" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Thyroid hormone receptor-interacting factor 13 (TRIP13) contributes to the development of several cancers, including hepatocellular carcinoma (HCC). Although these studies have found that TRIP13 is involved in other cancers, its specific function in gastric cancer requires further investigation. Therefore, this study aimed to investigate the hypothesis that LINC00511 may act as an oncogenic factor in gastric cancer by influencing and regulating the expression level of TRIP13. This relationship has the potential to reveal the molecular mechanisms driving gastric cancer progression and further elucidate the roles of LINC00511 and TRIP13 in gastric cancer. In this study, we confirmed that LINC00511 could act as a ceRNA targeting miR-29c-3p to further regulate the expression of TRIP13. LINC00511 was also found to be able to be positively regulated by the transcription factor IRF9. In addition, TRIP13 could activate the AKT/mTOR pathway by interacting with its downstream protein ACTN2, thus promoting the proliferation of GC cells. lnc-LINC00511 could promote GC progression by regulating the miR-29c-3p/TRIP13 axis and activating the AKT/mTOR pathway. </div> <a href="javascript:ShowArticleAbstract(5);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords5" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastric+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastric cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22LINC00511%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LINC00511</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TRIP13%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TRIP13</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcription+factor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcription factor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ceRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ceRNA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22miR-29c-3p%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">miR-29c-3p</a></li></ul> <a href="javascript:ShowArticleKeywords(5);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh5" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22TOR+Serine-Threonine+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">TOR Serine-Threonine Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proto-Oncogene+Proteins+c-akt%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proto-Oncogene Proteins c-akt/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Disease+Progression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Disease Progression</a></li></ul> <a href="javascript:ShowArticleMeSH(5);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant5" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(5);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors5" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yanyan+Wu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yanyan Wu</a></li><ul><li>Department of Ultrasonic, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xuanyan+Guo%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xuanyan Guo</a></li><ul><li>Department of Ultrasonic, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Li+Jin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Li Jin</a></li><ul><li>State Key Laboratory of Quality Research in Chinese Medicine, School of Pharmacy, Macau University of Science and Technology, Taipa 999078, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Guixiang+Huang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Guixiang Huang</a></li><ul><li>Department of Emergency Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Section 2, Yihuan Road, Qingyang District, Chengdu 610000, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liangbo+Niu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liangbo Niu</a></li><ul><li>Department of Emergency Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Section 2, Yihuan Road, Qingyang District, Chengdu 610000, China.<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yu+Zhao%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yu Zhao</a></li><ul><li>Department of Emergency Medicine, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 32, West Section 2, Yihuan Road, Qingyang District, Chengdu 610000, China.<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(5);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow6"> <td style="min-width:40px;text-align:center;"> 6 </td> <td> <div id="citation6" class="article-citation"> <b>Ning B</b>, Huang T, Liu Y, Wei Y. A depression-related lncRNA signature predicts the clinical outcome and immune characteristics of gastric cancer. <em class='incite-journal-name' onclick='ShowInCiteJournal(171993);'>Heliyon</em> 2024;<b>10</b>:e34399. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39144985' target='_blank'>39144985</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11320146' target='_blank'>PMC11320146</a> DOI: <a href='https://dx.doi.org/10.1016/j.heliyon.2024.e34399' target='_blank'>10.1016/j.heliyon.2024.e34399</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.heliyon.2024.e34399','39144985', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(6);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(6);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.heliyon.2024.e34399' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/5f7e2268940b5c69df3716f34e78fe7d/main.PMC11320146.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1016/j.heliyon.2024.e34399');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(171993);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/29/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/29/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/09/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/16/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.1016/j.heliyon.2024.e34399" /> <div style="display:none" id="articleAbstract6" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-label">Background</div><div class="abstract-content">Depression and long non-coding RNA (lncRNA) have been reported to be associated with tumor progression and prognosis in gastric cancer (GC). This study aims to build a GC risk classification and prognosis model based on depression-related lncRNAs (DRLs). </div><div class="abstract-label">Methods</div><div class="abstract-content">To develop a risk model, we performed univariate Cox regression and least absolute shrinkage and selection operator (LASSO) regression analyses using RNA sequencing data of GC from The Cancer Genome Atlas (TCGA) and depression-related genes (DRGs) from previous studies. Kaplan-Meier analysis, receiver operating characteristic (ROC) curve analysis, nomogram construction, pathway enrichment analysis, assessment of immunological features, and drug sensitivity testing were conducted using a series of bioinformatics methods. </div><div class="abstract-label">Results</div><div class="abstract-content">Seven DRLs were identified to build a prognostic model, whose robustness was verified in an internal cohort. Subsequent prognostic analyses found that high risk scores were associated with worse overall survival (OS). Univariate and multivariate analyses revealed that the risk score could be used as an independent prognostic factor. Furthermore, the ROC curve indicated that the risk score had higher diagnostic efficiency than traditional clinicopathological features. The calibration curve confirmed the accuracy and reliability of the nomogram. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses showed that there were differences in digestive system and nervous system-related pathways between the high- and low-risk groups. Results of tumor mutational burden (TMB) and tumor immune dysfunction and exclusion (TIDE) analyses indicated that patients in the low-risk group had a better response rate to immunotherapy. Finally, the results of drug sensitivity analysis showed that risk score could influence sensitivity to EHT 1864 in GC. </div><div class="abstract-label">Conclusion</div><div class="abstract-content">We have successfully developed and verified a 7-DRL risk model which can assess the prognosis and immunological features and guide individualized therapy of GC patients. </div> <a href="javascript:ShowArticleAbstract(6);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords6" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Depression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Depression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastric+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastric cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Risk+model%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Risk model</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lncRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lncRNA</a></li></ul> <a href="javascript:ShowArticleKeywords(6);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh6" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(6);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant6" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(6);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors6" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biao+Ning%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biao Ning</a></li><ul><li>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, 169, Donghu Road, Wuchang District, Wuhan, Hubei Province, 430071, China<li><li>Hubei Key Laboratory of Tumor Biological Behaviors Zhongnan Hospital of Wuhan University, 169, Donghu Road, Wuchang District, Wuhan, Hubei Province, 430071, China<li><li>Hubei Cancer Clinical Study Center Zhongnan Hospital of Wuhan University, 169, Donghu Road, Wuchang District, Wuhan, Hubei Province, 430071, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tianhe+Huang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tianhe Huang</a></li><ul><li>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, 169, Donghu Road, Wuchang District, Wuhan, Hubei Province, 430071, China<li><li>Hubei Key Laboratory of Tumor Biological Behaviors Zhongnan Hospital of Wuhan University, 169, Donghu Road, Wuchang District, Wuhan, Hubei Province, 430071, China<li><li>Hubei Cancer Clinical Study Center Zhongnan Hospital of Wuhan University, 169, Donghu Road, Wuchang District, Wuhan, Hubei Province, 430071, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yixin+Liu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yixin Liu</a></li><ul><li>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, 169, Donghu Road, Wuchang District, Wuhan, Hubei Province, 430071, China<li><li>Hubei Key Laboratory of Tumor Biological Behaviors Zhongnan Hospital of Wuhan University, 169, Donghu Road, Wuchang District, Wuhan, Hubei Province, 430071, China<li><li>Hubei Cancer Clinical Study Center Zhongnan Hospital of Wuhan University, 169, Donghu Road, Wuchang District, Wuhan, Hubei Province, 430071, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yongchang+Wei%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yongchang Wei</a></li><ul><li>Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, 169, Donghu Road, Wuchang District, Wuhan, Hubei Province, 430071, China<li><li>Hubei Key Laboratory of Tumor Biological Behaviors Zhongnan Hospital of Wuhan University, 169, Donghu Road, Wuchang District, Wuhan, Hubei Province, 430071, China<li><li>Hubei Cancer Clinical Study Center Zhongnan Hospital of Wuhan University, 169, Donghu Road, Wuchang District, Wuhan, Hubei Province, 430071, China<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(6);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow7"> <td style="min-width:40px;text-align:center;"> 7 </td> <td> <div id="citation7" class="article-citation"> <b>Liu N</b>, Zhang C, Zhang L. WTAP-Involved the m6A Modification of lncRNA FAM83H-AS1 Accelerates the Development of Gastric Cancer. <em class='incite-journal-name' onclick='ShowInCiteJournal(17004);'>Mol Biotechnol</em> 2024;<b>66</b>:1883-1893. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37477820' target='_blank'>37477820</a> DOI: <a href='https://dx.doi.org/10.1007/s12033-023-00810-2' target='_blank'>10.1007/s12033-023-00810-2</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1007%2fs12033-023-00810-2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1007%2fs12033-023-00810-2')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s12033-023-00810-2','37477820', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(7);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(7);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(7);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s12033-023-00810-2' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17004);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/12/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/28/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/22/2023]</span></span> </div> <input type="hidden" value="10.1007/s12033-023-00810-2" /> <div style="display:none" id="articleAbstract7" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">The long noncoding RNA FAM83H-antisense RNA 1 (FAM83H-AS1) is involved in gastric cancer (GC) development. This study determined whether FAM83H-AS1 was regulated by N6-methyladenosine (m6A) modifications in GC. Real-time quantitative polymerase chain reaction was performed to determine the expression levels of FAM83H-AS1 and Wilms' tumor 1 associated protein (WTAP). The protein content of WTAP was evaluated using western blotting. To assess the m6A alterations in FAM83H-AS1, methylated RNA immunoprecipitation was performed to identify interactions between WTAP and FAM83H-AS1. Functionally, the proliferation, migration, and invasion of GC cells were measured using a Cell Counting Kit-8 and transwell assays, respectively. High expression levels of FAM83H-AS1 and WTAP were detected in GC samples and there was a positive correlation between them. In addition, WTAP mediates FAM83H-AS1 expression in an m6A-dependent manner. Further investigations indicated that WTAP silencing reversed the cancer-promoting role of FAM83H-AS1 overexpression in GC cell migration, proliferation, and invasion. Our results suggest that WTAP-mediated FAM83H-AS1 promotes GC development via m6A modification. Our findings provide new biomarkers for GC diagnosis and targeted therapy. </div> <a href="javascript:ShowArticleAbstract(7);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords7" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22FAM83H-AS1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">FAM83H-AS1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastric+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastric cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wilms%e2%80%99+tumor+1+associated+protein%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wilms’ tumor 1 associated protein</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22m6A+modification%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">m6A modification</a></li></ul> <a href="javascript:ShowArticleKeywords(7);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh7" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/metabolism</a></li><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA+Splicing+Factors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA Splicing Factors/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Cycle+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Cycle Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Cycle+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Cycle Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proteins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proteins</a></li></ul> <a href="javascript:ShowArticleMeSH(7);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant7" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(7);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors7" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nian+Liu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nian Liu</a></li><ul><li>Department of Gastrointestinal Surgery, The Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, Hongkong Rd. No. 168, Jianghan District, Wuhan, 430015, Hubei, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chao+Zhang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chao Zhang</a></li><ul><li>Department of Gastrointestinal Surgery, The Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, Hongkong Rd. No. 168, Jianghan District, Wuhan, 430015, Hubei, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liang+Zhang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liang Zhang</a></li><ul><li>Department of Gastrointestinal Surgery, The Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, Hongkong Rd. No. 168, Jianghan District, Wuhan, 430015, Hubei, China.<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(7);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow8"> <td style="min-width:40px;text-align:center;"> 8 </td> <td> <div id="citation8" class="article-citation"> <b>Xie XZ</b>, Zuo L, Huang W, Fan QM, Weng YY, Yao WD, Jiang JL, Jin JQ. FDX1 as a novel biomarker and treatment target for stomach adenocarcinoma. <em class='incite-journal-name' onclick='ShowInCiteJournal(23589);'>World J Gastrointest Surg</em> 2024;<b>16</b>:1803-1824. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38983344' target='_blank'>38983344</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11230022' target='_blank'>PMC11230022</a> DOI: <a href='https://dx.doi.org/10.4240/wjgs.v16.i6.1803' target='_blank'>10.4240/wjgs.v16.i6.1803</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.4240/wjgs.v16.i6.1803','38983344', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(8);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(8);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.wjgnet.com/1948-9366/full/v16/i6/1803.htm' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.f6publishing.com/forms/main/DownLoadFile.aspx?Type=Digital&TypeId=1&id=10.4240%2fwjgs.v16.i6.1803&FilePath=B10B747B908CF2B4047433871A0239D8B685B8705FB84264D6CEE7B206937EB0A367DE061163CA7B3C4C46DDC3246978BFA96B46241AFCFBF08D02D66A79F98D577FAA14117AD119' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(23589);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.f6publishing.com/' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/21/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 04/25/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 04/28/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/27/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.4240/wjgs.v16.i6.1803" /> <div style="display:none" id="articleAbstract8" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Stomach adenocarcinoma (STAD) is one of the main reasons for cancer-related deaths worldwide. This investigation aimed to define the connection between STAD and Cuproptosis-related genes (CRGs). Cuproptosis is a newly identified form of mitochondrial cell death triggered by copper. </div><div class="abstract-label">AIM</div><div class="abstract-content">To explore the identification of potential biomarkers for STAD disease based on cuproptosis. </div><div class="abstract-label">METHODS</div><div class="abstract-content">A predictive model using Gene Ontology (GO), Least Absolute Shrinkage and Selection Operator (LASSO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Set Variation Analysis (GSVA), and Gene Set Enrichment Analysis analyzed gene interconnections, focusing on 3 copper-related genes and their expression in The Cancer Genome Atlas-STAD. Networks for mRNA-miRNA and mRNA-transcription factor interactions were constructed. The prognostic significance of CRG scores was evaluated using time-receiver operating characteristic, Kaplan-Meier curves, and COX regression analysis. Validation was conducted with datasets GSE26942, GSE54129, and GSE66229. Expression of copper-related differentially expressed genes was also analyzed in various human tissues and gastric cancer subpopulations using the human protein atlas. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Three significant genes (FDX1, LIAS, MTF1) were identified and selected via LASSO analysis to predict and classify individuals with STAD into high and low CRG score subgroups. These genes were down-regulated in both risk categories. GO and KEGG analyses highlighted their involvement mainly in the electron transport chain. After validating their differential expression, FDX1 emerged as the most accurate diagnostic marker for gastric cancer. Additionally, the RCircos package localized FDX1 on chromosome 11. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Our study revealed that FDX1 could be a potential biomarker and treatment target for gastric malignancy, providing new ideas for further scientific research. </div> <a href="javascript:ShowArticleAbstract(8);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords8" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Copper+death%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Copper death</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cuproptosis-related+genes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cuproptosis-related genes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22FDX1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">FDX1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+adenocarcinoma+disease%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach adenocarcinoma disease</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22prognostic+biomarkers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">prognostic biomarkers</a></li></ul> <a href="javascript:ShowArticleKeywords(8);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh8" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(8);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant8" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(8);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors8" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xian-Ze+Xie%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xian-Ze Xie</a></li><ul><li>Department of Pharmacy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310018, Zhejiang Province, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lei+Zuo%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lei Zuo</a></li><ul><li>Anhui Province Huainan City Shou County Agricultural Machinery Affairs Management Center, Huainan 232200, Anhui Province, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wei+Huang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wei Huang</a></li><ul><li>Department of Pharmacy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310018, Zhejiang Province, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Qiao-Mei+Fan%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Qiao-Mei Fan</a></li><ul><li>Department of Pharmacy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310018, Zhejiang Province, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ya-Yun+Weng%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ya-Yun Weng</a></li><ul><li>Department of Pharmacy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310018, Zhejiang Province, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wen-Dong+Yao%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wen-Dong Yao</a></li><ul><li>Department of Pharmacy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310018, Zhejiang Province, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jia-Li+Jiang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jia-Li Jiang</a></li><ul><li>Department of Pharmacy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310018, Zhejiang Province, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jia-Qi+Jin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jia-Qi Jin</a></li><ul><li>Department of Pharmacy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310018, Zhejiang Province, China<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(8);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow9"> <td style="min-width:40px;text-align:center;"> 9 </td> <td> <div id="citation9" class="article-citation"> <b>Vijayakumar S</b>, DiGuiseppi JA, Dabestani PJ, Ryan WG, Quevedo RV, Li Y, Diers J, Tu S, Fleegel J, Nguyen C, Rhoda LM, Imami AS, Hamoud ARA, Lovas S, McCullumsmith RE, Zallocchi M, Zuo J. In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss. <em>SCIENCE ADVANCES</em> 2024;<b>10</b>:eadk2299. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38896614' target='_blank'>38896614</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11186505' target='_blank'>PMC11186505</a> DOI: <a href='https://dx.doi.org/10.1126/sciadv.adk2299' target='_blank'>10.1126/sciadv.adk2299</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1126/sciadv.adk2299','38896614', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(9);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(9);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(9);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1126/sciadv.adk2299' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/09/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/14/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/21/2024]</span></span> </div> <input type="hidden" value="10.1126/sciadv.adk2299" /> <div style="display:none" id="articleAbstract9" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Noise-induced hearing loss (NIHL) is a common sensorineural hearing impairment that lacks U.S. Food and Drug Administration-approved drugs. To fill the gap in effective screening models, we used an in silico transcriptome-based drug screening approach, identifying 22 biological pathways and 64 potential small molecule treatments for NIHL. Two of these, afatinib and zorifertinib [epidermal growth factor receptor (EGFR) inhibitors], showed efficacy in zebrafish and mouse models. Further tests with EGFR knockout mice and EGF-morpholino zebrafish confirmed their protective role against NIHL. Molecular studies in mice highlighted EGFR's crucial involvement in NIHL and the protective effect of zorifertinib. When given orally, zorifertinib was found in the perilymph with favorable pharmacokinetics. In addition, zorifertinib combined with AZD5438 (a cyclin-dependent kinase 2 inhibitor) synergistically prevented NIHL in zebrafish. Our results underscore the potential for in silico transcriptome-based drug screening in diseases lacking efficient models and suggest EGFR inhibitors as potential treatments for NIHL, meriting clinical trials. </div> <a href="javascript:ShowArticleAbstract(9);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords9" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(9);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh9" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a 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State</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DOD%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DOD</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bellucci+Family+Foundation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bellucci Family Foundation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22US+Navy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">US Navy</a></li></ul> <a href="javascript:ShowArticleGrant(9);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors9" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sarath+Vijayakumar%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sarath Vijayakumar</a></li><ul><li>Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68178, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Joseph+A.+DiGuiseppi%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Joseph A. DiGuiseppi</a></li><ul><li>Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68178, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Parinaz+Jila+Dabestani%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Parinaz Jila Dabestani</a></li><ul><li>Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68178, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22William+G.+Ryan%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">William G. Ryan</a></li><ul><li>Department of Neurosciences<sub>,</sub> University of Toledo, Toledo, OH 43614, USA<sub>.</sub><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rene+Vielman+Quevedo%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rene Vielman Quevedo</a></li><ul><li>Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68178, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yuju+Li%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yuju Li</a></li><ul><li>Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68178, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jack+Diers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jack Diers</a></li><ul><li>Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68178, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Shu+Tu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Shu Tu</a></li><ul><li>Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68178, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jonathan+Fleegel%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jonathan Fleegel</a></li><ul><li>Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68178, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cassidy+Nguyen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cassidy Nguyen</a></li><ul><li>Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68178, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lauren+M.+Rhoda%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lauren M. Rhoda</a></li><ul><li>Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68178, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ali+Sajid+Imami%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ali Sajid Imami</a></li><ul><li>Department of Neurosciences<sub>,</sub> University of Toledo, Toledo, OH 43614, USA<sub>.</sub><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Abdul-Rizaq+Ali+Hamoud%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Abdul-Rizaq Ali Hamoud</a></li><ul><li>Department of Neurosciences<sub>,</sub> University of Toledo, Toledo, OH 43614, USA<sub>.</sub><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22S%c3%a1ndor+Lovas%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sándor Lovas</a></li><ul><li>Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68178, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Robert+E.+McCullumsmith%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Robert E. McCullumsmith</a></li><ul><li>Department of Neurosciences<sub>,</sub> University of Toledo, Toledo, OH 43614, USA<sub>.</sub><li><li>Neurosciences Institute, ProMedica, Toledo, OH 43606, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Marisa+Zallocchi%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Marisa Zallocchi</a></li><ul><li>Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68178, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jian+Zuo%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jian Zuo</a></li><ul><li>Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE 68178, USA<li><li>Ting Therapeutics, University of California San Diego, 9310 Athena Circle, San Diego, CA 92037, USA<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(9);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow10"> <td style="min-width:40px;text-align:center;"> 10 </td> <td> <div id="citation10" class="article-citation"> <b>Xia Y</b>, Sun M, Huang H, Jin WL. Drug repurposing for cancer therapy. <em class='incite-journal-name' onclick='ShowInCiteJournal(21209);'>Signal Transduct Target Ther</em> 2024;<b>9</b>:92. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38637540' target='_blank'>38637540</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11026526' target='_blank'>PMC11026526</a> DOI: <a href='https://dx.doi.org/10.1038/s41392-024-01808-1' target='_blank'>10.1038/s41392-024-01808-1</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41392-024-01808-1','38637540', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(10);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(10);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(10);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(10);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41392-024-01808-1' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(21209);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/06/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 03/05/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/19/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/20/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.1038/s41392-024-01808-1" /> <div style="display:none" id="articleAbstract10" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Cancer, a complex and multifactorial disease, presents a significant challenge to global health. Despite significant advances in surgical, radiotherapeutic and immunological approaches, which have improved cancer treatment outcomes, drug therapy continues to serve as a key therapeutic strategy. However, the clinical efficacy of drug therapy is often constrained by drug resistance and severe toxic side effects, and thus there remains a critical need to develop novel cancer therapeutics. One promising strategy that has received widespread attention in recent years is drug repurposing: the identification of new applications for existing, clinically approved drugs. Drug repurposing possesses several inherent advantages in the context of cancer treatment since repurposed drugs are typically cost-effective, proven to be safe, and can significantly expedite the drug development process due to their already established safety profiles. In light of this, the present review offers a comprehensive overview of the various methods employed in drug repurposing, specifically focusing on the repurposing of drugs to treat cancer. We describe the antitumor properties of candidate drugs, and discuss in detail how they target both the hallmarks of cancer in tumor cells and the surrounding tumor microenvironment. In addition, we examine the innovative strategy of integrating drug repurposing with nanotechnology to enhance topical drug delivery. We also emphasize the critical role that repurposed drugs can play when used as part of a combination therapy regimen. To conclude, we outline the challenges associated with repurposing drugs and consider the future prospects of these repurposed drugs transitioning into clinical application. </div> <a href="javascript:ShowArticleAbstract(10);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords10" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug+development%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug development</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cancer+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cancer therapy</a></li></ul> <a href="javascript:ShowArticleKeywords(10);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh10" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Repositioning%2fmethods%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Repositioning/methods</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Drug+Delivery+Systems%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Drug Delivery Systems</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Treatment+Outcome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Treatment Outcome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Combined+Modality+Therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Combined Modality Therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tumor+Microenvironment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tumor Microenvironment</a></li></ul> <a href="javascript:ShowArticleMeSH(10);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant10" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China+(National+Science+Foundation+of+China)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">82060442 National Natural Science Foundation of China (National Science Foundation of China)</a></li></ul> <a href="javascript:ShowArticleGrant(10);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors10" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ying+Xia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ying Xia</a></li><ul><li>Center for Clinical Laboratories, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, PR China<li><li>The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, 550001, PR China<li><li>School of Clinical Laboratory Science, Guizhou Medical University, Guiyang, 550004, PR China<li><li>Division of Gastroenterology and Hepatology, Department of Medicine and, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ming+Sun%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ming Sun</a></li><ul><li>Center for Clinical Laboratories, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, PR China<li><li>School of Clinical Laboratory Science, Guizhou Medical University, Guiyang, 550004, PR China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hai+Huang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hai Huang</a></li><ul><li>Center for Clinical Laboratories, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, PR China.<li><li>School of Clinical Laboratory Science, Guizhou Medical University, Guiyang, 550004, PR China.<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wei-Lin+Jin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wei-Lin Jin</a></li><ul><li>Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University, Lanzhou, 730000, PR China.<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(10);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow11"> <td style="min-width:40px;text-align:center;"> 11 </td> <td> <div id="citation11" class="article-citation"> <b>Lv M</b>, Li X, Yin Z, Yang H, Zhou B. Comprehensive analysis and validation reveal DEPDC1 as a potential diagnostic biomarker associated with tumor immunity in non-small-cell lung cancer. <em class='incite-journal-name' onclick='ShowInCiteJournal(19324);'>PLoS One</em> 2024;<b>19</b>:e0294227. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38564630' target='_blank'>38564630</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10986975' target='_blank'>PMC10986975</a> DOI: <a href='https://dx.doi.org/10.1371/journal.pone.0294227' target='_blank'>10.1371/journal.pone.0294227</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1371/journal.pone.0294227','38564630', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(11);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(11);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(11);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1371/journal.pone.0294227' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(19324);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/12/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/20/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/04/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.1371/journal.pone.0294227" /> <div style="display:none" id="articleAbstract11" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Current evidence suggests that DEP domain containing 1 (DEPDC1) has an important effect on non-small-cell lung cancer (NSCLC). However, the diagnostic value and the regulatory function within NSCLC are largely unclear. This work utilized publicly available databases and in vitro experiments for exploring, DEPDC1 expression, clinical features, diagnostic significance and latent molecular mechanism within NSCLC. According to our results, DEPDC1 was remarkably upregulated in the tissues of NSCLC patients compared with non-carcinoma tissues, linked with gender, stage, T classification and N classification based on TCGA data and associated with smoking status and stage according to GEO datasets. Meanwhile, the summary receiver operating characteristic (sROC) curve analysis result showed that DEPDC1 had a high diagnostic value in NSCLC (AUC = 0.96, 95% CI: 0.94-0.98; diagnostic odds ratio = 99.08, 95%CI: 31.91-307.65; sensitivity = 0.89, 95%CI: 0.81-0.94; specificity = 0.92, 95%CI: 0.86-0.96; positive predictive value = 0.94, 95%CI: 0.89-0.98; negative predictive value = 0.78, 95%CI: 0.67-0.90; positive likelihood ratio = 11.77, 95%CI: 6.11-22.68; and negative likelihood ratio = 0.12, 95%CI: 0.06-0.22). Subsequently, quantitative real-time PCR (qRT-PCR) and western blotting indicated that DEPDC1 was high expressed in NSCLC cells. According to the in vitro MTS and apoptotic assays, downregulated DEPDC1 expression targeting P53 signaling pathway inhibited the proliferation of NSCLC cells while promoting apoptosis of NSCLC cells. Moreover, DEPDC1 was significantly correlated with immune cell infiltrating levels in NSCLC based on TCGA data, which were primarily associated with T cells CD4 memory activated, macrophages M1, B cells memory, mast cells resting, T cells regulatory, monocytes, and T cells CD4 memory resting. Compared with the group with high expression of DEPDC1, the group with low expression level had higher scores for immune checkpoint inhibitors (ICIs) treatment. GSEA confirmed that DEPDC1 was involved in gene expression and tumor-related signaling pathways. Finally, DEPDC1 and its associated immune-related genes were shown to be enriched in 'receptor ligand activity', 'external side of plasma membrane', 'regulation of innate immune response', and 'Epstein-Barr virus infection' pathways. The present study demonstrates that DEPDC1 may contribute to NSCLC tumorigenesis and can be applied as the biomarker for diagnosis and immunology. </div> <a href="javascript:ShowArticleAbstract(11);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords11" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(11);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh11" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Non-Small-Cell+Lung%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Non-Small-Cell Lung/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Non-Small-Cell+Lung%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Non-Small-Cell Lung/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Carcinoma%2c+Non-Small-Cell+Lung%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Carcinoma, Non-Small-Cell Lung/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+Neoplasms%2fdiagnosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung Neoplasms/diagnosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epstein-Barr+Virus+Infections%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epstein-Barr Virus Infections</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Herpesvirus+4%2c+Human%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Herpesvirus 4, Human/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasm+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasm Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22GTPase-Activating+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">GTPase-Activating Proteins/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(11);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant11" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">National Natural Science Foundation of China</a></li></ul> <a href="javascript:ShowArticleGrant(11);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors11" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Meiwen+Lv%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Meiwen Lv</a></li><ul><li><addr-line>Department of Clinical Epidemiology, The First Hospital of China Medical University, Heping District, Shenyang, China</addr-line><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xuelian+Li%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xuelian Li</a></li><ul><li><addr-line>Department of Epidemiology, School of Public Health of China Medical University, Shenyang, China</addr-line><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zhihua+Yin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zhihua Yin</a></li><ul><li><addr-line>Department of Epidemiology, School of Public Health of China Medical University, Shenyang, China</addr-line><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22He+Yang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">He Yang</a></li><ul><li><addr-line>Department of Clinical Epidemiology, The First Hospital of China Medical University, Heping District, Shenyang, China</addr-line><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Baosen+Zhou%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Baosen Zhou</a></li><ul><li><addr-line>Department of Clinical Epidemiology, The First Hospital of China Medical University, Heping District, Shenyang, China</addr-line><li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(11);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow12"> <td style="min-width:40px;text-align:center;"> 12 </td> <td> <div id="citation12" class="article-citation"> <b>Ma WQ</b>, Miao MC, Ding PA, Tan BB, Liu WB, Guo S, Er LM, Zhang ZD, Zhao Q. CALD1 facilitates epithelial-mesenchymal transition progression in gastric cancer cells by modulating the PI3K-Akt pathway. <em class='incite-journal-name' onclick='ShowInCiteJournal(23587);'>World J Gastrointest Oncol</em> 2024;<b>16</b>:1029-1045. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38577446' target='_blank'>38577446</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10989365' target='_blank'>PMC10989365</a> DOI: <a href='https://dx.doi.org/10.4251/wjgo.v16.i3.1029' target='_blank'>10.4251/wjgo.v16.i3.1029</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.4251/wjgo.v16.i3.1029','38577446', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(12);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(12);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.wjgnet.com/1948-5204/full/v16/i3/1029.htm' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.f6publishing.com/forms/main/DownLoadFile.aspx?Type=Digital&TypeId=1&id=10.4251%2fwjgo.v16.i3.1029&FilePath=542F4CBCE054804E513E85CC9967D006A56DF1F17C128EDC58B41BE3D5CA19141842BD20103742C78C4CD6DEC32288486D88EA7C7CD9994A8C360C057991BFD15B7EC12DD852D641' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(23587);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.f6publishing.com/' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 11/22/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/21/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/04/2024]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/12/2024]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.4251/wjgo.v16.i3.1029" /> <div style="display:none" id="articleAbstract12" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">CALD1 has been discovered to be abnormally expressed in a variety of malignant tumors, including gastric cancer (GC), and is associated with tumor progression and immune infiltration; however, the roles and mechanisms of CALD1 in epithelial-mesenchymal transition (EMT) in GC are unknown. </div><div class="abstract-label">AIM</div><div class="abstract-content">To investigate the role and mechanism of CALD1 in GC progression, invasion, and migration. </div><div class="abstract-label">METHODS</div><div class="abstract-content">In this study, the relationship between CALD1 and GC, as well as the possible network regulatory mechanisms of CALD1, was investigated by bioinformatics and validated by experiments. CALD1-siRNA was synthesized and used to transfect GC cells. Cell activity was measured using the CCK-8 method, cell migration and invasive ability were measured using wound healing assay and Transwell assay, and the expression levels of relevant genes and proteins in each group of cells were measured using qRT-PCR and Western blot. A GC cell xenograft model was established to verify the results of in vitro experiments. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Bioinformatics results showed that CALD1 was highly expressed in GC tissues, and CALD1 was significantly higher in EMT-type GC tissues than in tissues of other types of GC. The prognosis of patients with high expression of CALD1 was worse than that of patients with low expression, and a prognostic model was constructed and evaluated. The experimental results were consistent with the results of the bioinformatics analysis. The expression level of CALD1 in GC cell lines was all higher than that in gastric epithelial cell line GES-1, with the strongest expression found in AGS and MKN45 cells. Cell activity was significantly reduced after CALD1-siRNA transfection of AGS and MKN45 cells. The ability of AGS and MKN45 cells to migrate and invade was reduced after CALD1-siRNA transfection, and the related mRNA and protein expression was altered. According to bioinformatics findings in GC samples, the CALD1 gene was significantly associated with the expression of members of the PI3K-AKT-mTOR signaling pathway as well as the EMT signaling pathway, and was closely related to the PI3K-Akt signaling pathway. Experimental validation revealed that upregulation of CALD1 increased the expression of PI3K, p-AKT, and p-mTOR, members of the PI3K-Akt pathway,while decreasing the expression of PTEN; PI3K-Akt inhibitor treatment decreased the expression of PI3K, p-AKT, and p-mTOR in cells overexpressing CALD1 (still higher than that in the normal group), but increased the expression of PTEN (still lower than that in the normal group). CCK-8 results revealed that the effect of CALD1 on tumor cell activity was decreased by the addition of the inhibitor. Scratch and Transwell experiments showed that the effect of CALD1 on tumor cell migration and invasion was weakened by the addition of the PI3K-Akt inhibitor. The mRNA and protein levels of EMT-related genes in AGS and MKN45 cells were greatly altered by the overexpression of CALD1, whereas the effect of overexpression of CALD1 was significantly weakened by the addition of the PI3K-Akt inhibitor. Animal experiments showed that tumour growth was slow after inhibition of CALD1, and the expression of some PI3K-Akt and EMT pathway proteins was altered. </div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Increased expression of CALD1 is a key factor in the progression, invasion, and metastasis of GC, which may be associated with regulating the PI3K-Akt pathway to promote EMT. </div> <a href="javascript:ShowArticleAbstract(12);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords12" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bioinformatics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bioinformatics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CALD1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CALD1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epithelial-mesenchymal+transition%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epithelial-mesenchymal transition</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastric+tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastric tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+disruption%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene disruption</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Invasion%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Invasion</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Migration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Migration</a></li></ul> <a href="javascript:ShowArticleKeywords(12);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh12" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(12);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant12" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(12);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors12" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wen-Qian+Ma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wen-Qian Ma</a></li><ul><li>Department of Endoscopy, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China<li><li>Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang 050011, Hebei Province, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ming-Chang+Miao%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ming-Chang Miao</a></li><ul><li>Department of Radiotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ping-An+Ding%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ping-An Ding</a></li><ul><li>Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang 050011, Hebei Province, China<li><li>The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bi-Bo+Tan%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bi-Bo Tan</a></li><ul><li>Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang 050011, Hebei Province, China<li><li>The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wen-Bo+Liu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wen-Bo Liu</a></li><ul><li>Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang 050011, Hebei Province, China<li><li>The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Shuo+Guo%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Shuo Guo</a></li><ul><li>Department of Endoscopy, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China<li><li>Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang 050011, Hebei Province, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Li-Mian+Er%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Li-Mian Er</a></li><ul><li>Department of Endoscopy, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China<li><li>Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang 050011, Hebei Province, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zhi-Dong+Zhang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zhi-Dong Zhang</a></li><ul><li>Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang 050011, Hebei Province, China<li><li>The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Qun+Zhao%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Qun Zhao</a></li><ul><li>Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang 050011, Hebei Province, China<li><li>The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(12);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow13"> <td style="min-width:40px;text-align:center;"> 13 </td> <td> <div id="citation13" class="article-citation"> <b>Chen J</b>, Liang H, Wu Y, Li C. Phosphoproteomics changes due to allograft-induced stress responses of Pinctada fucata martensii. <em>COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. PART D, GENOMICS & PROTEOMICS</em> 2024;<b>49</b>:101153. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37956605' target='_blank'>37956605</a> DOI: <a href='https://dx.doi.org/10.1016/j.cbd.2023.101153' target='_blank'>10.1016/j.cbd.2023.101153</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.cbd.2023.101153','37956605', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(13);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(13);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(13);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.cbd.2023.101153' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/29/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/01/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/03/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/15/2023]</span></span> </div> <input type="hidden" value="10.1016/j.cbd.2023.101153" /> <div style="display:none" id="articleAbstract13" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Protein phosphorylation modifications are post-translational modifications (PTMs) that play important roles in signal transduction and immune regulation. Implanting a spherical nucleus into a recipient shellfish is critical in marine pearl aquaculture. Protein phosphorylation may be important in the immune responses of Pinctada fucata martensii after nucleus implantation, but their involvement in regulation remains unclear. Here, phosphoproteomics of P. f. martensii gill tissues was conducted 12 h after nuclear implantation using label-free data-independent acquisition (DIA) with LC-MS/MS. Among the 4024 phosphorylated peptides with quantitative information, 181 were up-regulated and 148 were down-regulated. Functional enrichment analysis of these differentially expressed phosphorylated proteins (DEPPs) revealed significant enrichment in functions related to membrane trafficking, exosomes, cytoskeleton, and signal transduction mechanisms. Further, 16 conserved motifs were identified among the DEPPs, including the RSphP, SphP, RSphA, RSphE, PTphP, and ATphP motifs that were significantly conserved, and which may be related to specific kinase recognition. Parallel response monitoring (PRM) analysis validated the abundances of 12 DEPPs from the proteomics, indicating that the phosphoproteomics analyses were robust. 12 DEPPs were selected from the proteomics results through Quantitative real-time PCR (qPCR) technology, and verification analysis was conducted at the gene level. The study suggests that kinases such as MAPKs, Akt, and CK2 may regulate the phosphorylation of related proteins following nuclear implantation. Furthermore, the important signaling pathways of Rap 1, IL-17A, and NF-κB, which are influenced by phosphorylated or dephosphorylated proteins, are found to be involved in this response. Overall, this study revealed the protein phosphorylation responses after nucleus implantation in P. f. martensii, helping to elucidate the characteristics and mechanisms of immune regulation responses in P. f. martensii, in addition to promoting a further understanding of protein phosphorylation modification functions in P. f. martensii. </div> <a href="javascript:ShowArticleAbstract(13);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords13" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune regulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nucleus+implantation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nucleus implantation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Phosphorylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Phosphorylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pinctada+fucata+martensii%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pinctada fucata martensii</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Proteomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Proteomics</a></li></ul> <a href="javascript:ShowArticleKeywords(13);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh13" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pinctada%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pinctada/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chromatography%2c+Liquid%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chromatography, Liquid</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tandem+Mass+Spectrometry%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tandem Mass Spectrometry</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immunity%2c+Innate%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immunity, Innate/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Allografts%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Allografts</a></li></ul> <a href="javascript:ShowArticleMeSH(13);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant13" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(13);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors13" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jie+Chen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jie Chen</a></li><ul><li>Fisheries College, Guangdong Ocean University, Zhanjiang 524088, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Haiying+Liang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Haiying Liang</a></li><ul><li>Fisheries College, Guangdong Ocean University, Zhanjiang 524088, China; Guangdong Provincial Key Laboratory of Aquatic Animal Disease Control and Healthy Culture, Zhanjiang 524088, China.<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yifan+Wu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yifan Wu</a></li><ul><li>Fisheries College, Guangdong Ocean University, Zhanjiang 524088, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chaojie+Li%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chaojie Li</a></li><ul><li>Fisheries College, Guangdong Ocean University, Zhanjiang 524088, China<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(13);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow14"> <td style="min-width:40px;text-align:center;"> 14 </td> <td> <div id="citation14" class="article-citation"> <b>Zhang Y</b>, Guo S, Mao T, Guo J, Zhang Q, Tian Z, Li X. Tumor-Derived Exosomal LINC01480 Upregulates VCAM1 Expression by Acting as a Competitive Endogenous RNA of miR-204-5p to Promote Gastric Cancer Progression. <em class='incite-journal-name' onclick='ShowInCiteJournal(321);'>ACS Biomater Sci Eng</em> 2024;<b>10</b>:550-562. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38133901' target='_blank'>38133901</a> DOI: <a href='https://dx.doi.org/10.1021/acsbiomaterials.3c00394' target='_blank'>10.1021/acsbiomaterials.3c00394</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1021%2facsbiomaterials.3c00394%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1021%2facsbiomaterials.3c00394')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1021/acsbiomaterials.3c00394','38133901', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(14);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(14);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(14);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1021/acsbiomaterials.3c00394' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(321);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/23/2023]</span></span> </div> <input type="hidden" value="10.1021/acsbiomaterials.3c00394" /> <div style="display:none" id="articleAbstract14" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Exosomes are a type of cell-derived vesicles that range in size from 30 to 100 nm. They are widely present in various organisms and participate in diverse biological processes, playing crucial roles in tumorigenesis and progression. This study aimed to investigate whether LINC01480 in tumor-derived exosomes is involved in the molecular mechanism of gastric cancer by competitively upregulating the VCAM1 expression through binding miR-204-5p. The study analyzed transcriptome data related to gastric cancer from the cancer genome atlas database and constructed a risk-scoring model for epithelial-mesenchymal transition (EMT)-related lncRNAs to identify eight EMT-related lncRNAs associated with prognosis. EMT-related mRNAs positively correlated with LINC01480 were screened in the ExoRBase database. In vitro cell experiments showed that exosomal LINC01480 can promote the proliferation, migration, invasion, and EMT of gastric cancer cells by upregulating VCAM1 expression through competitive binding with miR-204-5p. In vivo experiments on nude mice showed that exosomal LINC01480 promotes the development of gastric cancer. These results suggest that exosomal LINC01480 could be a potential therapeutic target for gastric cancer. </div> <a href="javascript:ShowArticleAbstract(14);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords14" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22LINC01480%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LINC01480</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22VCAM1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">VCAM1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22epithelial%e2%88%92mesenchymal+transition%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">epithelial−mesenchymal transition</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22exosomes%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">exosomes</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gastric+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gastric cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22microRNA-204-5p%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">microRNA-204-5p</a></li></ul> <a href="javascript:ShowArticleKeywords(14);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh14" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Competitive+Endogenous%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Competitive Endogenous</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%2c+Nude%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice, Nude</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li></ul> <a href="javascript:ShowArticleMeSH(14);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant14" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(14);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors14" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yu+Zhang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yu Zhang</a></li><ul><li>Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266000, P. R. China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Shan+Guo%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Shan Guo</a></li><ul><li>Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266000, P. R. China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tao+Mao%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tao Mao</a></li><ul><li>Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266000, P. R. China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jing+Guo%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jing Guo</a></li><ul><li>Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266000, P. R. China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Qi+Zhang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Qi Zhang</a></li><ul><li>Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266000, P. R. China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zibin+Tian%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zibin Tian</a></li><ul><li>Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266000, P. R. China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xiaoyu+Li%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xiaoyu Li</a></li><ul><li>Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao 266000, P. R. China<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(14);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow15"> <td style="min-width:40px;text-align:center;"> 15 </td> <td> <div id="citation15" class="article-citation"> <b>Qiao X</b>, Chen Y, Wang Z, Peng N, Niu W, Hou S, Wu J, Ji Y, Niu C, Cheng C. GTF2E2 downregulated by miR-340-5p inhibits the malignant progression of glioblastoma. <em class='incite-journal-name' onclick='ShowInCiteJournal(4460);'>Cancer Gene Ther</em> 2023;<b>30</b>:1702-1714. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37845349' target='_blank'>37845349</a> DOI: <a href='https://dx.doi.org/10.1038/s41417-023-00676-1' target='_blank'>10.1038/s41417-023-00676-1</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41417-023-00676-1','37845349', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(15);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(15);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41417-023-00676-1' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4460);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/02/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/08/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/29/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/18/2023]</span></span> </div> <input type="hidden" value="10.1038/s41417-023-00676-1" /> <div style="display:none" id="articleAbstract15" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Glioblastoma is the most common malignant tumor in the central nervous system. The general transcription factor IIE subunit beta (GTF2E2) is crucial for physiological and pathological functions, but its roles in the malignant biological function of glioma remain ambiguous. CCK-8, colony formation assays, TUNEL assays, cell migration assays, wound-healing assays, and xenograft model were established to investigate the biological functions of GTF2E2 both in vitro and in vivo. GTF2E2 was overexpressed in glioma and was associated with poor prognosis of glioma patients. Biological functions of GTF2E2 were investigated both in vitro and in vi0vo by multiple experiments. Moreover, we explored the possible mechanisms of GTF2E2. In our results, we demonstrated that GTF2E2 could be regulated by miR-340-5p directly or indirectly. CCND1 was transcriptionally affected by GTF2E2 and glioma progression was then regulated. Our data presented the overexpression of GTF2E2 in glioma and indicated the association between GTF2E2 and glioma prognosis. GTF2E2 was found to be regulated by miR-340-5p and thus affect downstream gene expressions and glioma progression. Our results indicate that GTF2E2 might be a potential target in the diagnosis and treatments of glioblastoma. </div> <a href="javascript:ShowArticleAbstract(15);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords15" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(15);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh15" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Brain+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Brain Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Movement%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Movement/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glioblastoma%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glioblastoma/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Glioma%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Glioma/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcription+Factors%2c+TFII%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcription Factors, TFII/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcription+Factors%2c+TFII%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcription Factors, TFII/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(15);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant15" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(15);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors15" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xiaolong+Qiao%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xiaolong Qiao</a></li><ul><li>Anhui University of Science and Technology, 232001, Huainan, Anhui, China<li><li>Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001, Hefei, Anhui, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yinan+Chen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yinan Chen</a></li><ul><li>Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001, Hefei, Anhui, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zixuan+Wang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zixuan Wang</a></li><ul><li>Dalian Medical University, 116000, Dalian, Liaoning, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nan+Peng%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nan Peng</a></li><ul><li>Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001, Hefei, Anhui, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wanxiang+Niu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wanxiang Niu</a></li><ul><li>Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001, Hefei, Anhui, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Shiqiang+Hou%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Shiqiang Hou</a></li><ul><li>Department of Neurosurgery, The Affiliated Chuzhou Hospital of Anhui Medical University, The First People's Hospital of Chuzhou, 239000, Chuzhou, Anhui, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jiaying+Wu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jiaying Wu</a></li><ul><li>Bengbu Medical College, 233000, Bengbu, Anhui, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ying+Ji%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ying Ji</a></li><ul><li>Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001, Hefei, Anhui, China.<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chaoshi+Niu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chaoshi Niu</a></li><ul><li>Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001, Hefei, Anhui, China.<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chuandong+Cheng%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chuandong Cheng</a></li><ul><li>Anhui University of Science and Technology, 232001, Huainan, Anhui, China.<li><li>Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 230001, Hefei, Anhui, China.<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(15);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow16"> <td style="min-width:40px;text-align:center;"> 16 </td> <td> <div id="citation16" class="article-citation"> <b>Deng H</b>, Gao J, Cao B, Qiu Z, Li T, Zhao R, Li H, Wei B. LncRNA CCAT2 promotes malignant progression of metastatic gastric cancer through regulating CD44 alternative splicing. <em class='incite-journal-name' onclick='ShowInCiteJournal(4818);'>Cell Oncol (Dordr)</em> 2023;<b>46</b>:1675-1690. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37354353' target='_blank'>37354353</a> DOI: <a href='https://dx.doi.org/10.1007/s13402-023-00835-4' target='_blank'>10.1007/s13402-023-00835-4</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s13402-023-00835-4','37354353', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(16);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(16);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(16);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(16);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s13402-023-00835-4' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4818);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/30/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/26/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.1007/s13402-023-00835-4" /> <div style="display:none" id="articleAbstract16" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-label">OBJECTIVE</div><div class="abstract-content">Gastric cancer (GC) is one of the most malignant tumors worldwide. Thus, it is necessary to explore the underlying mechanisms of GC progression and develop novel therapeutic regimens. Long non-coding RNAs (lncRNAs) have been demonstrated to be abnormally expressed and regulate the malignant behaviors of cancer cells. Our previous research demonstrated that lncRNA colon cancer-associated transcript 2 (CCAT2) has potential value for GC diagnosis and discrimination. However, the functional mechanisms of lncRNA CCAT2 in GC development remain to be explored. </div><div class="abstract-label">METHODS</div><div class="abstract-content">GC and normal adjacent tissues were collected to detect the expression of lncRNA CCAT2, ESRP1 and CD44 in clinical specimens and their clinical significance for GC patients. Cell counting kit-8, wound healing and transwell assays were conducted to investigate the malignant behaviors in vitro. The generation of nude mouse xenografts by subcutaneous, intraperitoneal and tail vein injection was performed to examine GC growth and metastasis in vivo. Co-immunoprecipitation, RNA-binding protein pull-down assay and fluorescence in situ hybridization were performed to reveal the binding relationships between ESRP1 and CD44. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">In the present study, lncRNA CCAT2 was overexpressed in GC tissues compared to adjacent normal tissues and correlated with short survival time of patients. lncRNA CCAT2 promoted the proliferation, migration and invasion of GC cells. Its overexpression modulates alternative splicing of Cluster of differentiation 44 (CD44) variants and facilitates the conversion from the standard form to variable CD44 isoform 6 (CD44v6). Mechanistically, lncRNA CCAT2 upregulated CD44v6 expression by binding to epithelial splicing regulatory protein 1 (ESRP1), which subsequently mediates CD44 alternative splicing. The oncogenic role of the lncRNA CCAT2/ESRP1/CD44 axis in the promotion of malignant behaviors was verified by both in vivo and in vitro experiments. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Our findings identified a novel mechanism by which lncRNA CCAT2, as a type of protein-binding RNA, regulates alternative splicing of CD44 and promotes GC progression. This axis may become an effective target for clinical diagnosis and treatment. </div> <a href="javascript:ShowArticleAbstract(16);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords16" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alternative+splicing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alternative splicing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CD44%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CD44</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22ESRP1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">ESRP1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastric+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastric cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Malignant+behavior%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Malignant behavior</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lncRNA+CCAT2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lncRNA CCAT2</a></li></ul> <a href="javascript:ShowArticleKeywords(16);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh16" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Animals%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Animals</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mice%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mice</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alternative+Splicing%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alternative Splicing/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Up-Regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Up-Regulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22In+Situ+Hybridization%2c+Fluorescence%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">In Situ Hybridization, Fluorescence</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%2c+Tumor%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers, Tumor/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Colonic+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Colonic Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyaluronan+Receptors%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyaluronan Receptors/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hyaluronan+Receptors%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hyaluronan Receptors/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(16);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant16" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">82073192 and 81773135 National Natural Science Foundation of China</a></li></ul> <a href="javascript:ShowArticleGrant(16);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors16" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Huan+Deng%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Huan Deng</a></li><ul><li>Department of Gastrointestinal Surgery, Peking University First Hospital, Beijing, 100034, China<li><li>Department of General Surgery, First Medical Center, Chinese PLA General Hospital, 28 Fuxing Rd, Beijing, 100853, China<li><li>Medical School of Chinese PLA, Beijing, 100853, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jingwang+Gao%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jingwang Gao</a></li><ul><li>Department of General Surgery, First Medical Center, Chinese PLA General Hospital, 28 Fuxing Rd, Beijing, 100853, China<li><li>Medical School of Chinese PLA, Beijing, 100853, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bo+Cao%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bo Cao</a></li><ul><li>Department of General Surgery, First Medical Center, Chinese PLA General Hospital, 28 Fuxing Rd, Beijing, 100853, China<li><li>Medical School of Chinese PLA, Beijing, 100853, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ziyu+Qiu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ziyu Qiu</a></li><ul><li>Health Service Department of the Guard Bureau of the General Office of the Central Committee of the Communist Party of China, Beijing, 100091, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tian+Li%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tian Li</a></li><ul><li>School of Basic Medicine, The Fourth Military Medical University, Xi'an, 710021, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ruiyang+Zhao%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ruiyang Zhao</a></li><ul><li>Department of General Surgery, First Medical Center, Chinese PLA General Hospital, 28 Fuxing Rd, Beijing, 100853, China<li><li>Medical School of Chinese PLA, Beijing, 100853, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hanghang+Li%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hanghang Li</a></li><ul><li>Department of General Surgery, First Medical Center, Chinese PLA General Hospital, 28 Fuxing Rd, Beijing, 100853, China<li><li>Medical School of Chinese PLA, Beijing, 100853, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bo+Wei%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bo Wei</a></li><ul><li>Department of General Surgery, First Medical Center, Chinese PLA General Hospital, 28 Fuxing Rd, Beijing, 100853, China.<li><li>Medical School of Chinese PLA, Beijing, 100853, China.<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(16);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow17"> <td style="min-width:40px;text-align:center;"> 17 </td> <td> <div id="citation17" class="article-citation"> <b>Shaemi F</b>, Nejati M, Sarrafnia H, Mahabady MK, Tamtaji Z, Taheri AT, Hamblin MR, Zolfaghari MR, Heydari A, Mirzaei H. Expression of selected long non-coding RNAs in gastric cancer cells treated with coumarin: Possible mechanisms for anti-cancer activity. <em class='incite-journal-name' onclick='ShowInCiteJournal(169769);'>Pathol Res Pract</em> 2023;<b>252</b>:154914. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37992506' target='_blank'>37992506</a> DOI: <a href='https://dx.doi.org/10.1016/j.prp.2023.154914' target='_blank'>10.1016/j.prp.2023.154914</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.prp.2023.154914','37992506', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(17);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(17);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(17);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.prp.2023.154914' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(169769);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/prp/default2.aspx' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/10/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/26/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/26/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/24/2023]</span></span> </div> <input type="hidden" value="10.1016/j.prp.2023.154914" /> <div style="display:none" id="articleAbstract17" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Long non-coding RNAs (lncRNAs) can be utilized as prognostic indicators of gastric cancer since they can affect several cancer-related processes. Coumarin is a natural product with some useful anti-cancer properties. Here, we measured the expression of selected lncRNAs (RuPAR, SNHG6, CASC11, and their targets, miR-340-5p, p21, E-cadherin, and CDK1) in AGS gastric cancer cells treated with coumarin. MTT test has been utilized for assessing the AGS cells' cell viability after exposure to coumarin. The expression of the lncRNAs (RuPAR, SNHG6, and CASC11) and miR-340-5p was evaluated via qRT-PCR. Western blot analysis has been utilized to determine changes in p21, E-cadherin, and CDK1 expression. Coumarin decreased AGS viability in a dose-dependent manner. The coumarin treated cells had lower levels of the mRNAs known to be targets of lncRNAs SNHG6 and CASC11 compared to control. Additionally, the coumarin group had increased levels of lncRNA RuPAR expression when compared with the control group. Some lncRNA targets, including p21, E-cadherin, and CDK1, showed lower expression in the coumarin group compared to the control by Western blotting. Coumarin could be a promising pharmacological candidate to be included in gastric cancer treatment regimens because it modulates lncRNAs and their targets. </div> <a href="javascript:ShowArticleAbstract(17);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords17" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CASC11%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CASC11</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Coumarin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Coumarin</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastric+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastric cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Long+non-coding+RNAs%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Long non-coding RNAs</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MiR-340%e2%80%935p%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MiR-340–5p</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RuPAR%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RuPAR</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SNHG6%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SNHG6</a></li></ul> <a href="javascript:ShowArticleKeywords(17);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh17" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cadherins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cadherins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Coumarins%2fpharmacology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Coumarins/pharmacology</a></li></ul> <a href="javascript:ShowArticleMeSH(17);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant17" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(17);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors17" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fatemeh+Shaemi%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fatemeh Shaemi</a></li><ul><li>Department of Genetics, Faculty of Basic Science, Qom Branch, Islamic Azad University, Qom, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Majid+Nejati%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Majid Nejati</a></li><ul><li>Anatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Haleh+Sarrafnia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Haleh Sarrafnia</a></li><ul><li>Faculty of Biological Sciences, Islamic Azad University, Tehran-North Branch, Tehran, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mahmood+Khaksary+Mahabady%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mahmood Khaksary Mahabady</a></li><ul><li>Anatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zeinab+Tamtaji%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zeinab Tamtaji</a></li><ul><li>Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Abdolkarim+Talebi+Taheri%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Abdolkarim Talebi Taheri</a></li><ul><li>Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Michael+R+Hamblin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Michael R Hamblin</a></li><ul><li>Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein 2028, South Africa<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mohammad+Reza+Zolfaghari%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mohammad Reza Zolfaghari</a></li><ul><li>Department of Microbiology, Faculty of Basic Science, Qom Branch, Islamic Azad University, Qom, Iran.<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Azhdar+Heydari%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Azhdar Heydari</a></li><ul><li>Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran; Department of Physiology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hamed+Mirzaei%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hamed Mirzaei</a></li><ul><li>Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(17);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow18"> <td style="min-width:40px;text-align:center;"> 18 </td> <td> <div id="citation18" class="article-citation"> <b>Sahib AS</b>, Fawzi A, Zabibah RS, Koka NA, Khudair SA, Muhammad FA, Hamad DA. miRNA/epithelial-mesenchymal axis (EMT) axis as a key player in cancer progression and metastasis: A focus on gastric and bladder cancers. <em class='incite-journal-name' onclick='ShowInCiteJournal(5348);'>Cell Signal</em> 2023;<b>112</b>:110881. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37666286' target='_blank'>37666286</a> DOI: <a href='https://dx.doi.org/10.1016/j.cellsig.2023.110881' target='_blank'>10.1016/j.cellsig.2023.110881</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1016%2fj.cellsig.2023.110881%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 2</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1016%2fj.cellsig.2023.110881')">Impact Index Per Article: 2.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.cellsig.2023.110881','37666286', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(18);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(18);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(18);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.cellsig.2023.110881' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(5348);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/05/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/30/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/01/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/06/2023]</span></span> </div> <input type="hidden" value="10.1016/j.cellsig.2023.110881" /> <div style="display:none" id="articleAbstract18" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">The metastasis a major hallmark of tumors that its significant is not only related to the basic research, but clinical investigations have revealed that majority of cancer deaths are due to the metastasis. The metastasis of tumor cells is significantly increased due to EMT mechanism and therefore, inhibition of EMT can reduce biological behaviors of tumor cells and improve the survival rate of patients. One of the gaps related to cancer metastasis is lack of specific focus on the EMT regulation in certain types of tumor cells. The gastric and bladder cancers are considered as two main reasons of death among patients in clinical level. Herein, the role of EMT in regulation of their progression is evaluated with a focus on the function of miRNAs. The inhibition/induction of EMT in these cancers and their ability in modulation of EMT-related factors including ZEB1/2 proteins, TGF-β, Snail and cadherin proteins are discussed. Moreover, lncRNAs and circRNAs in crosstalk of miRNA/EMT regulation in these tumors are discussed and final impact on cancer metastasis and response of tumor cells to the chemotherapy is evaluated. Moreover, the impact of miRNAs transferred by exosomes in regulation of EMT in these cancers are discussed. </div> <a href="javascript:ShowArticleAbstract(18);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords18" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bladder+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bladder cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chemoresistance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chemoresistance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epigenetic+factors%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epigenetic factors</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastric+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastric cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22miRNAs%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">miRNAs</a></li></ul> <a href="javascript:ShowArticleKeywords(18);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh18" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNAs%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNAs/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Urinary+Bladder+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Urinary Bladder Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epithelial-Mesenchymal+Transition%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epithelial-Mesenchymal Transition</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasm+Metastasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasm Metastasis</a></li></ul> <a href="javascript:ShowArticleMeSH(18);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant18" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(18);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors18" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ameer+S+Sahib%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ameer S Sahib</a></li><ul><li>Department of Pharmacy, Al- Mustaqbal University College, 51001 Hilla, Iraq<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amjid+Fawzi%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amjid Fawzi</a></li><ul><li>Medical Technical College, Al-Farahidi University, Iraq<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rahman+S+Zabibah%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rahman S Zabibah</a></li><ul><li>Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nisar+Ahmad+Koka%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nisar Ahmad Koka</a></li><ul><li>Department of English, Faculty of Languages and Translation, King Khalid University, Abha, Kingdom of Saudi Arabia.<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Shaymaa+Abdulhameed+Khudair%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Shaymaa Abdulhameed Khudair</a></li><ul><li>Advanced Biomedical Science, Al-Nisour University College, Baghdad, Iraq<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Faris+Anad+Muhammad%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Faris Anad Muhammad</a></li><ul><li>Department of Pharmacy, Al-Noor University College, Nineveh, Iraq<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Doaa+A+Hamad%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Doaa A Hamad</a></li><ul><li>Nursing Department, Hilla University College, Babylon, Iraq<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(18);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow19"> <td style="min-width:40px;text-align:center;"> 19 </td> <td> <div id="citation19" class="article-citation"> <b>Rajan JR</b>, McDonald S, Bjourson AJ, Zhang SD, Gibson DS. An AI Approach to Identifying Novel Therapeutics for Rheumatoid Arthritis. <em class='incite-journal-name' onclick='ShowInCiteJournal(15196);'>J Pers Med</em> 2023;<b>13</b>:1633. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/38138860' target='_blank'>38138860</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10744895' target='_blank'>PMC10744895</a> DOI: <a href='https://dx.doi.org/10.3390/jpm13121633' target='_blank'>10.3390/jpm13121633</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/jpm13121633','38138860', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(19);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(19);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(19);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/jpm13121633' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(15196);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/12/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 11/11/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/20/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/24/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.3390/jpm13121633" /> <div style="display:none" id="articleAbstract19" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Rheumatoid arthritis (RA) is a chronic autoimmune disorder that has a significant impact on quality of life and work capacity. Treatment of RA aims to control inflammation and alleviate pain; however, achieving remission with minimal toxicity is frequently not possible with the current suite of drugs. This review aims to summarise current treatment practices and highlight the urgent need for alternative pharmacogenomic approaches for novel drug discovery. These approaches can elucidate new relationships between drugs, genes, and diseases to identify additional effective and safe therapeutic options. This review discusses how computational approaches such as connectivity mapping offer the ability to repurpose FDA-approved drugs beyond their original treatment indication. This review also explores the concept of drug sensitisation to predict co-prescribed drugs with synergistic effects that produce enhanced anti-disease efficacy by involving multiple disease pathways. Challenges of this computational approach are discussed, including the availability of suitable high-quality datasets for comprehensive analysis and other data curation issues. The potential benefits include accelerated identification of novel drug combinations and the ability to trial and implement established treatments in a new index disease. This review underlines the huge opportunity to incorporate disease-related data and drug-related data to develop methods and algorithms that have strong potential to determine novel and effective treatment regimens. </div> <a href="javascript:ShowArticleAbstract(19);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords19" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22connectivity+mapping%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">connectivity mapping</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22drug+repurposing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">drug repurposing</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22rheumatoid+arthritis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">rheumatoid arthritis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22transcriptomics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">transcriptomics</a></li></ul> <a href="javascript:ShowArticleKeywords(19);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh19" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(19);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant19" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Department+of+Economy+Postgraduate+Studentship%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">82758Q Department of Economy Postgraduate Studentship</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Northern+Ireland+Rheumatism+Trust%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">82493R Northern Ireland Rheumatism Trust</a></li></ul> <a href="javascript:ShowArticleGrant(19);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors19" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jency+R.+Rajan%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jency R. Rajan</a></li><ul><li>Personalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT47 6SB, UK; <email></email> (J.R.R.); <email></email> (A.J.B.); <email></email> (S.-D.Z.)<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stephen+McDonald%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stephen McDonald</a></li><ul><li>Rheumatology Department, Altnagelvin Hospital, Western Health and Social Care Trust, Londonderry BT47 6SB, UK; <email></email><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anthony+J.+Bjourson%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anthony J. Bjourson</a></li><ul><li>Personalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT47 6SB, UK; <email></email> (J.R.R.); <email></email> (A.J.B.); <email></email> (S.-D.Z.)<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Shu-Dong+Zhang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Shu-Dong Zhang</a></li><ul><li>Personalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT47 6SB, UK; <email></email> (J.R.R.); <email></email> (A.J.B.); <email></email> (S.-D.Z.)<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22David+S.+Gibson%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">David S. Gibson</a></li><ul><li>Personalised Medicine Centre, School of Medicine, Ulster University, Londonderry BT47 6SB, UK; <email></email> (J.R.R.); <email></email> (A.J.B.); <email></email> (S.-D.Z.)<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(19);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow20"> <td style="min-width:40px;text-align:center;"> 20 </td> <td> <div id="citation20" class="article-citation"> <b>Sha R</b>, Zhang J, Meng F, Zhaori G. Gastric cancer metastasis-related NT5DC2 indicates unfavorable prognosis of patients. <em class='incite-journal-name' onclick='ShowInCiteJournal(16719);'>Medicine (Baltimore)</em> 2023;<b>102</b>:e35030. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37800836' target='_blank'>37800836</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553061' target='_blank'>PMC10553061</a> DOI: <a href='https://dx.doi.org/10.1097/md.0000000000035030' target='_blank'>10.1097/md.0000000000035030</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1097%2fmd.0000000000035030%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1097%2fmd.0000000000035030')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1097/md.0000000000035030','37800836', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(20);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(20);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(20);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1097/md.0000000000035030' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(16719);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://preflight.paperpal.com/partner/wolterskluwer/medicine/submit' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/21/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/10/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 10/07/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.1097/md.0000000000035030" /> <div style="display:none" id="articleAbstract20" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-label">PURPOSE</div><div class="abstract-content">Approximately 80 to 90% of patients with gastric cancer (GC) eventually develop into metastatic GC nowadays,because GC is difficult to be diagnosed at an early stage. GC patients with metastases typically have a poor prognosis. It is necessary to explore a potential prognostic marker in metastatic GC. </div><div class="abstract-label">METHODS</div><div class="abstract-content">All GC data were obtained from The Cancer Genome Atlas and Gene Expression Omnibus databases. The metastasis-related candidate gene and its role in GC were analyzed by comprehensive analysis. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Totally 1049 metastasis-related genes were identified in GC. Univariate Cox regression analysis screened the top 10 genes (PDHX, SLC43A1, CSAG2, NT5DC2, CSAG1, FMN1, MED1, HIVEP2, FNDC3A, and PPP1R2) that were closely correlated with prognosis of GC patients. Among which, NT5DC2 was screened as the target gene for subsequent study. The NT5DC2 expression were increased in primary GC and metastatic GC samples. Moreover, GC patients with high NT5DC2 expression exhibited shorter overall survival and post progression survival, and the NT5DC2 was metastatic GC patients' independent prognostic factor. Totally 29 pathways were activated in metastatic GC samples with high NT5DC2 expression. Four immune cells' infiltration were significantly different between NT5DC2 high and low expressed metastatic GC patients. NT5DC2 showed significantly negative correlations with 6 types of immune cells' critical marker genes and 5 types of immune cell infiltration. The 10 immune checkpoint expressions were decreased in high NTDC2 expression metastatic GC patients. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">NT5DC2 plays a prognostic role in metastatic GC. GC patients with high NT5DC2 expression indicates unfavorable prognosis. </div> <a href="javascript:ShowArticleAbstract(20);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords20" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gastric+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gastric cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22metastasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">metastasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22nt5dc2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">nt5dc2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22prognosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">prognosis</a></li></ul> <a href="javascript:ShowArticleKeywords(20);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh20" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antigens%2c+Neoplasm%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antigens, Neoplasm</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Databases%2c+Factual%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Databases, Factual</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasm+Proteins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasm Proteins</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prognosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prognosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Splenic+Neoplasms%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Splenic Neoplasms</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms/genetics</a></li></ul> <a href="javascript:ShowArticleMeSH(20);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant20" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(20);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors20" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rula+Sha%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rula Sha</a></li><ul><li>Department of Internal Medicine-Oncology, Inner Mongolia Autonomous Region People’s Hospital, Hohhot, Inner Mongolia, P.R. China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jiaming+Zhang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jiaming Zhang</a></li><ul><li>Department of Internal Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia, P.R. China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fanjie+Meng%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fanjie Meng</a></li><ul><li>Department of Internal Medicine, Inner Mongolia Medical University, Hohhot, Inner Mongolia, P.R. China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Getu+Zhaori%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Getu Zhaori</a></li><ul><li>Department of Abdominal Surgery, The Affiliated People’s Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, P.R. China<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(20);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow21"> <td style="min-width:40px;text-align:center;"> 21 </td> <td> <div id="citation21" class="article-citation"> <b>Chen F</b>, Wang L. Long noncoding RNA CASC11 suppresses sorafenib-triggered ferroptosis via stabilizing SLC7A11 mRNA in hepatocellular carcinoma cells. <em class='incite-journal-name' onclick='ShowInCiteJournal(10440);'>Discov Oncol</em> 2023;<b>14</b>:145. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37552314' target='_blank'>37552314</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10409942' target='_blank'>PMC10409942</a> DOI: <a href='https://dx.doi.org/10.1007/s12672-023-00761-9' target='_blank'>10.1007/s12672-023-00761-9</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s12672-023-00761-9','37552314', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(21);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(21);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(21);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s12672-023-00761-9' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(10440);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://submission.nature.com/new-submission/12672/3' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/27/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/27/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 08/09/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.1007/s12672-023-00761-9" /> <div style="display:none" id="articleAbstract21" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">As a frontline treatment for patients with advanced hepatocellular carcinoma (HCC), sorafenib is an effective drug approved by the Food and Drug Administration (FDA). Ferroptosis, a newly defined programmed cell death process with the hallmark of the accumulation of iron-dependent lipid peroxides, can be induced by sorafenib treatment. Our previous study identified oncogenic roles of long noncoding RNA (lncRNA) Cancer susceptibility candidate 11 (CASC11) in HCC progression. However, the relationship between CASC11 and sorafenib-induced ferroptosis in HCC remains unclear. In the present study, we aim to investigate the role of CASC11 in sorafenib-induced ferroptosis in HCC cell lines and determine the involved molecular mechanisms. Here, we demonstrated that sorafenib decreased CASCL11 expression. Knockdown of CASC11 enhanced sorafenib-induced ferroptosis, while overexpression of CASC11 exerted the opposite effect in HCC cells. Moreover, CASC11 led to the accumulation of intracellular malondialdehyde (MDA), lipid reactive oxygen species (ROS) and Fe2+ while depleting glutathione (GSH), thereby suppressing sorafenib-induced ferroptosis and cell death. Ferrostatin-1 (Ferr-1), a ferroptosis inhibitor, reversed the enhanced anticancer effect of sorafenib caused by the silence of CASC11 in HCC cells. Mechanistically, CASC11 upregulated the expression of solute carrier family 7 member 11 (SLC7A11) which is critical for ferroptosis inhibition. CASC11 associated with and stabilized SLC7A11 mRNA. In summary, our data revealed, for the first time, that CASC11 inhibits the sorafenib-induced ferroptosis in HCC cells via regulating SLC7A11, providing a new basis for clinical therapeutic strategies for patients with HCC. </div> <a href="javascript:ShowArticleAbstract(21);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords21" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ferroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ferroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22SLC7A11%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">SLC7A11</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sorafenib%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sorafenib</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22mRNA+stability%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">mRNA stability</a></li></ul> <a href="javascript:ShowArticleKeywords(21);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh21" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(21);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant21" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">81902452 National Natural Science Foundation of China</a></li></ul> <a href="javascript:ShowArticleGrant(21);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors21" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fei+Chen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fei Chen</a></li><ul><li>Department of Ultrasound, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liang+Wang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liang Wang</a></li><ul><li>Department of General Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121001, Liaoning Province, China.<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(21);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow22"> <td style="min-width:40px;text-align:center;"> 22 </td> <td> <div id="citation22" class="article-citation"> <b>Nowak P</b>, Bil-Lula I, Śliwińska-Mossoń M. A Cross-Talk about Radioresistance in Lung Cancer-How to Improve Radiosensitivity According to Chinese Medicine and Medicaments That Commonly Occur in Pharmacies. <em class='incite-journal-name' onclick='ShowInCiteJournal(11724);'>Int J Mol Sci</em> 2023;<b>24</b>:11206. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37446385' target='_blank'>37446385</a> DOI: <a href='https://dx.doi.org/10.3390/ijms241311206' target='_blank'>10.3390/ijms241311206</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3390%2fijms241311206%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 2</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3390%2fijms241311206')">Impact Index Per Article: 2.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/ijms241311206','37446385', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(22);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(22);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/ijms241311206' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11724);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/31/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/21/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/27/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/15/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.3390/ijms241311206" /> <div style="display:none" id="articleAbstract22" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Lung cancer is one of the most common cancers in the population and is characterized by non-specific symptoms that delay the diagnosis and reduce the effectiveness of oncological treatment. Due to the difficult placement of the tumor, one of the main methods of lung cancer treatment is radiotherapy, which damages the DNA of cancer cells, inducing their apoptosis. However, resistance to ionizing radiation may develop during radiotherapy cycles, leading to an increase in the number of DNA points of control that protect cells from apoptosis. Cancer stem cells are essential for radioresistance, and due to their ability to undergo epithelial-mesenchymal transition, they modify the phenotype, bypassing the genotoxic effect of radiotherapy. It is therefore necessary to search for new methods that could improve the cytotoxic effect of cells through new mechanisms of action. Chinese medicine, with several thousand years of tradition, offers a wide range of possibilities in the search for compounds that could be used in conventional medicine. This review introduces the potential candidates that may present a radiosensitizing effect on lung cancer cells, breaking their radioresistance. Additionally, it includes candidates taken from conventional medicine-drugs commonly available in pharmacies, which may also be significant candidates.</div> <a href="javascript:ShowArticleAbstract(22);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords22" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lung+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lung cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22radiotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">radiotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22traditional+Chinese+medicine%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">traditional Chinese medicine</a></li></ul> <a href="javascript:ShowArticleKeywords(22);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh22" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(22);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant22" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(22);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors22" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Paulina+Nowak%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Paulina Nowak</a></li><ul><li>Scientific Club of Specialized Biological Analyzes, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Iwona+Bil-Lula%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Iwona Bil-Lula</a></li><ul><li>Department of Medical Laboratory Diagnostics, Division of Clinical Chemistry and Laboratory Hematology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mariola+%c5%9aliwi%c5%84ska-Mosso%c5%84%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mariola Śliwińska-Mossoń</a></li><ul><li>Department of Medical Laboratory Diagnostics, Division of Clinical Chemistry and Laboratory Hematology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(22);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow23"> <td style="min-width:40px;text-align:center;"> 23 </td> <td> <div id="citation23" class="article-citation"> <b>Ghafouri-Fard S</b>, Harsij A, Hussen BM, Taheri M, Sharifi G. A review on the role of CASC11 in cancers. <em class='incite-journal-name' onclick='ShowInCiteJournal(9535);'>Front Cell Dev Biol</em> 2023;<b>11</b>:1131199. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37427385' target='_blank'>37427385</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326515' target='_blank'>PMC10326515</a> DOI: <a href='https://dx.doi.org/10.3389/fcell.2023.1131199' target='_blank'>10.3389/fcell.2023.1131199</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3389%2ffcell.2023.1131199%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 2</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3389%2ffcell.2023.1131199')">Impact Index Per Article: 2.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fcell.2023.1131199','37427385', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(23);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(23);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fcell.2023.1131199' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fcell.2023.1131199');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9535);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/24/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/16/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 07/11/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.3389/fcell.2023.1131199" /> <div style="display:none" id="articleAbstract23" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">The long non-coding RNA (lncRNA) cancer susceptibility 11 (CASC11) is a newly identified lncRNA located on chromosome 8q24.21. The expression of lncRNA CASC11 has been found to be elevated in different cancer types and the prognosis of the tumor is inversely correlated with the high CASC11 expression. Moreover, lncRNA CASC11 has an oncogenic function in cancers. The biological characteristics of the tumors, such as proliferation, migration, invasion, autophagy, and apoptosis can be controlled by this lncRNA. In addition to interacting with miRNAs, proteins, transcription factors, and other molecules, the lncRNA CASC11 modulates signaling pathways including Wnt/β-catenin and epithelial-mesenchymal transition. In this review, we have summarized studies on the role of lncRNA CASC11 in the carcinogenesis from cell lines, <i>in vivo</i>, and clinical perspectives.</div> <a href="javascript:ShowArticleAbstract(23);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords23" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CASC11%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CASC11</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22biomarker%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">biomarker</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22expression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">expression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lncRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lncRNA</a></li></ul> <a href="javascript:ShowArticleKeywords(23);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh23" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(23);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant23" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(23);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors23" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Soudeh+Ghafouri-Fard%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Soudeh Ghafouri-Fard</a></li><ul><li><institution>Department of Medical Genetics</institution>, <institution>School of Medicine</institution>, <institution>Shahid Beheshti University of Medical Sciences</institution>, <addr-line>Tehran</addr-line>, <country>Iran</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Atefeh+Harsij%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Atefeh Harsij</a></li><ul><li><institution>Phytochemistry Research Center</institution>, <institution>Shahid Beheshti University of Medical Sciences</institution>, <addr-line>Tehran</addr-line>, <country>Iran</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bashdar+Mahmud+Hussen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bashdar Mahmud Hussen</a></li><ul><li><institution>Department of Clinical Analysis</institution>, <institution>College of Pharmacy</institution>, <institution>Hawler Medical University</institution>, <addr-line>Erbil</addr-line>, <country>Iraq</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mohammad+Taheri%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mohammad Taheri</a></li><ul><li><institution>Institute of Human Genetics</institution>, <institution>Jena University Hospital</institution>, <addr-line>Jena</addr-line>, <country>Germany</country><li><li><institution>Urology and Nephrology Research Center</institution>, <institution>Shahid Beheshti University of Medical Sciences</institution>, <addr-line>Tehran</addr-line>, <country>Iran</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Guive+Sharifi%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Guive Sharifi</a></li><ul><li><institution>Skull Base Research Center</institution>, <institution>Loghman Hakim Hospital</institution>, <institution>Shahid Beheshti University of Medical Sciences</institution>, <addr-line>Tehran</addr-line>, <country>Iran</country><li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(23);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow24"> <td style="min-width:40px;text-align:center;"> 24 </td> <td> <div id="citation24" class="article-citation"> <b>Vijayakumar S</b>, DiGuiseppi JA, Dabestani J, Ryan WG, Vielman Quevedo R, Li Y, Diers J, Tu S, Fleegel J, Nguyen C, Rhoda LM, Imami AS, Hamoud AAR, Lovas S, McCullumsmith R, Zallocchi M, Zuo J. In Silico Transcriptome-based Screens Identify Epidermal Growth Factor Receptor Inhibitors as Therapeutics for Noise-induced Hearing Loss. <em>BIORXIV : THE PREPRINT SERVER FOR BIOLOGY</em> 2023:2023.06.07.544128. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37333346' target='_blank'>37333346</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10274759' target='_blank'>PMC10274759</a> DOI: <a href='https://dx.doi.org/10.1101/2023.06.07.544128' target='_blank'>10.1101/2023.06.07.544128</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1101/2023.06.07.544128','37333346', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(24);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1101/2023.06.07.544128' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/20/2023]</span></span> </div> <input type="hidden" value="10.1101/2023.06.07.544128" /> <div style="display:none" id="articleAbstract24" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Noise-Induced Hearing Loss (NIHL) represents a widespread disease for which no therapeutics have been approved by the Food and Drug Administration (FDA). Addressing the conspicuous void of efficacious in vitro or animal models for high throughput pharmacological screening, we utilized an in silico transcriptome-oriented drug screening strategy, unveiling 22 biological pathways and 64 promising small molecule candidates for NIHL protection. Afatinib and zorifertinib, both inhibitors of the Epidermal Growth Factor Receptor (EGFR), were validated for their protective efficacy against NIHL in experimental zebrafish and murine models. This protective effect was further confirmed with EGFR conditional knockout mice and EGF knockdown zebrafish, both demonstrating protection against NIHL. Molecular analysis using Western blot and kinome signaling arrays on adult mouse cochlear lysates unveiled the intricate involvement of several signaling pathways, with particular emphasis on EGFR and its downstream pathways being modulated by noise exposure and Zorifertinib treatment. Administered orally, Zorifertinib was successfully detected in the perilymph fluid of the inner ear in mice with favorable pharmacokinetic attributes. Zorifertinib, in conjunction with AZD5438 - a potent inhibitor of cyclin dependent kinase 2 - produced synergistic protection against NIHL in the zebrafish model. Collectively, our findings underscore the potential application of in silico transcriptome-based drug screening for diseases bereft of efficient screening models and posit EGFR inhibitors as promising therapeutic agents warranting clinical exploration for combatting NIHL. </div><div class="abstract-label">Highlights</div><div class="abstract-content">In silico transcriptome-based drug screens identify pathways and drugs against NIHL.EGFR signaling is activated by noise but reduced by zorifertinib in mouse cochleae.Afatinib, zorifertinib and EGFR knockout protect against NIHL in mice and zebrafish.Orally delivered zorifertinib has inner ear PK and synergizes with a CDK2 inhibitor. </div> <a href="javascript:ShowArticleAbstract(24);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords24" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(24);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh24" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(24);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant24" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(24);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors24" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <a href="javascript:ShowArticleAuthors(24);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow25"> <td style="min-width:40px;text-align:center;"> 25 </td> <td> <div id="citation25" class="article-citation"> <b>Zhang H</b>, Feng H, Yu T, Zhang M, Liu Z, Ma L, Liu H. Construction of an oxidative stress-related lncRNAs signature to predict prognosis and the immune response in gastric cancer. <em class='incite-journal-name' onclick='ShowInCiteJournal(20954);'>Sci Rep</em> 2023;<b>13</b>:8822. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37258567' target='_blank'>37258567</a> DOI: <a href='https://dx.doi.org/10.1038/s41598-023-35167-8' target='_blank'>10.1038/s41598-023-35167-8</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41598-023-35167-8','37258567', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(25);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(25);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41598-023-35167-8' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(20954);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 01/17/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 05/13/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/02/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.1038/s41598-023-35167-8" /> <div style="display:none" id="articleAbstract25" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Oxidative stress, as a characteristic of cellular aerobic metabolism, plays a crucial regulatory role in the development and metastasis of gastric cancer (GC). Long noncoding RNAs (lncRNAs) are important regulators in GC development. However, research on the prognostic patterns of oxidative stress-related lncRNAs (OSRLs) and their functions in the immune microenvironment is currently insufficient. We identified the OSRLs signature (DIP2A-IT1, DUXAP8, TP53TG1, SNHG5, AC091057.1, AL355001.1, ARRDC1-AS1, and COLCA1) from 185 oxidative stress-related genes in The Cancer Genome Atlas (TCGA) cohort via random survival forest and Cox analyses, and the results were subsequently validated in the Gene Expression Omnibus (GEO) dataset. The patients were divided into high- and low-risk groups by the risk score of the OSRLs signature. Longer overall survival was detected in the low-risk group than in the high-risk group in both the TCGA cohort (P < 0. 001, HR = 0.43, 95% CI 0.31-0.62) and the GEO cohort (P = 0.014, HR = 0.67, 95% CI 0.48-0.93). Next, multivariate Cox analysis identified that the risk model was an independent prognostic characteristic (HR > 1, P = 0.005), and time-dependent receiver operating characteristic (ROC) curve analysis and nomogram analysis were utilized to evaluate the predictive ability of the risk model. Next, gene set enrichment analysis revealed that the immune-related pathway, Wnt/[Formula: see text]-catenin signature, mammalian target of rapamycin complex 1 signature, and cytokine‒cytokine receptor interaction was enriched. High-risk patients were more responsive to CD200, TNFSF4, TNFSF9, and BTNL2 immune checkpoint blockade. The results of qRT‒PCR further proved the accuracy of our bioinformatic analysis. Overall, our study identified a novel OSRLs signature that can serve as a promising biomarker and prognostic indicator, which provides a personalized predictive approach for patient prognosis evaluation and treatment.</div> <a href="javascript:ShowArticleAbstract(25);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords25" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(25);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh25" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(25);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant25" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22General+Project+of+the+Education+Department+of+Liaoning+Provinc%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LJKZ0088 General Project of the Education Department of Liaoning Provinc</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liaoning+Revitalization+Talents+Program%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">XLYC2002045 Liaoning Revitalization Talents Program</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Shenyang+Science+and+Technology+Plan+Project%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">21-116-3-48 Shenyang Science and Technology Plan Project</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Scientific+Research+Project+from+Department+of+Education+of+Liaoning+Province%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">LQN201906 Scientific Research Project from Department of Education of Liaoning Province</a></li></ul> <a href="javascript:ShowArticleGrant(25);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors25" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hui+Zhang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hui Zhang</a></li><ul><li>School of Life Science, Liaoning University, Shenyang, 110036, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Huawei+Feng%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Huawei Feng</a></li><ul><li>School of Pharmaceutical Sciences, Liaoning University, Shenyang, 110036, China<li><li>Key Laboratory of Computational Simulation and Information Processing of Biomacromolecules of Liaoning Province, Shenyang, 110036, China<li><li>Liaoning Provincial Engineering Laboratory of Molecular Modeling and Design for Drug, Shenyang, 110036, China<li><li>Key Laboratory for Simulating Computation and Information Processing of Bio-Macromolecules of Shenyang, Shenyang, 110036, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tiansong+Yu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tiansong Yu</a></li><ul><li>School of Pharmaceutical Sciences, Liaoning University, Shenyang, 110036, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Man+Zhang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Man Zhang</a></li><ul><li>School of Life Science, Liaoning University, Shenyang, 110036, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zhikui+Liu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zhikui Liu</a></li><ul><li>Liaoning Huikang Testing and Evaluation Technology Co, Shenyang, 110036, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lidan+Ma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lidan Ma</a></li><ul><li>Dandong Customs Integrated Technical Service Center, Dandong, 118000, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hongsheng+Liu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hongsheng Liu</a></li><ul><li>School of Pharmaceutical Sciences, Liaoning University, Shenyang, 110036, China.<li><li>Key Laboratory of Computational Simulation and Information Processing of Biomacromolecules of Liaoning Province, Shenyang, 110036, China.<li><li>Liaoning Provincial Engineering Laboratory of Molecular Modeling and Design for Drug, Shenyang, 110036, China.<li><li>Key Laboratory for Simulating Computation and Information Processing of Bio-Macromolecules of Shenyang, Shenyang, 110036, China.<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(25);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow26"> <td style="min-width:40px;text-align:center;"> 26 </td> <td> <div id="citation26" class="article-citation"> <b>Hosseini SA</b>, Haddadi MH, Fathizadeh H, Nemati F, Aznaveh HM, Taraj F, Aghabozorgizadeh A, Gandomkar G, Bazazzadeh E. Long non-coding RNAs and gastric cancer: An update of potential biomarkers and therapeutic applications. <em class='incite-journal-name' onclick='ShowInCiteJournal(3668);'>Biomed Pharmacother</em> 2023;<b>163</b>:114407. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37100014' target='_blank'>37100014</a> DOI: <a href='https://dx.doi.org/10.1016/j.biopha.2023.114407' target='_blank'>10.1016/j.biopha.2023.114407</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1016%2fj.biopha.2023.114407%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 6</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1016%2fj.biopha.2023.114407')">Impact Index Per Article: 6.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.biopha.2023.114407','37100014', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(26);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(26);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.biopha.2023.114407' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3668);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/27/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 02/12/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/15/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/28/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.1016/j.biopha.2023.114407" /> <div style="display:none" id="articleAbstract26" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">The frequent metastasis of gastric cancer (GC) complicates the cure and therefore the development of effective diagnostic and therapeutic approaches is urgently necessary. In recent years, lncRNA has emerged as a drug target in the treatment of GC, particularly in the areas of cancer immunity, cancer metabolism, and cancer metastasis. This has led to the demonstration of the importance of these RNAs as prognostic, diagnostic and therapeutic agents. In this review, we provide an overview of the biological activities of lncRNAs in GC development and update the latest pathological activities, prognostic and diagnostic strategies, and therapeutic options for GC-related lncRNAs.</div> <a href="javascript:ShowArticleAbstract(26);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords26" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cancer+treatment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cancer treatment</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Clinical+relevance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Clinical relevance</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diagnostic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diagnostic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastric+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastric cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Long+non-coding+RNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Long non-coding RNA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Molecular+mechanisms%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Molecular mechanisms</a></li></ul> <a href="javascript:ShowArticleKeywords(26);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh26" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(26);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant26" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(26);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors26" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Sayedeh+Azimeh+Hosseini%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Sayedeh Azimeh Hosseini</a></li><ul><li>Department of Medical Biotechnology, School of Advanced Technology, Shahrekord University of Medical Sciences, Shahrekord, Iran; Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran; USERN office, Shahrekord University of Medical Sciences, Shahrekord, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mohammad+Hossein+Haddadi%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mohammad Hossein Haddadi</a></li><ul><li>Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hadis+Fathizadeh%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hadis Fathizadeh</a></li><ul><li>Student Research Committee, Sirjan School of Medical Sciences, Sirjan, Iran; Department of Laboratory sciences, Sirjan School of Medical Sciences, Sirjan, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Foroogh+Nemati%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Foroogh Nemati</a></li><ul><li>Department of Microbiology, Kashan University of Medical Sciences, Kashan, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hooman+Mahmoudi+Aznaveh%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hooman Mahmoudi Aznaveh</a></li><ul><li>Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, P.O. Box: 14115-154, Tehran, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Farima+Taraj%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Farima Taraj</a></li><ul><li>Department of Animal Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22AmirArsalan+Aghabozorgizadeh%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">AmirArsalan Aghabozorgizadeh</a></li><ul><li>Department of Cell and Molecular Biology and Microbiology, Faculty of Science and Technology, University of Isfahan, Isfahan, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Golmaryam+Gandomkar%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Golmaryam Gandomkar</a></li><ul><li>Department of Animal Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Elaheh+Bazazzadeh%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Elaheh Bazazzadeh</a></li><ul><li>Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, P.O. Box: 14115-154, Tehran, Iran<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(26);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow27"> <td style="min-width:40px;text-align:center;"> 27 </td> <td> <div id="citation27" class="article-citation"> <b>Fadaei M</b>, Kohansal M, Akbarpour O, Sami M, Ghanbariasad A. Network and functional analyses of differentially expressed genes in gastric cancer provide new biomarkers associated with disease pathogenesis. <em class='incite-journal-name' onclick='ShowInCiteJournal(167517);'>J Egypt Natl Canc Inst</em> 2023;<b>35</b>:8. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/37032412' target='_blank'>37032412</a> DOI: <a href='https://dx.doi.org/10.1186/s43046-023-00164-5' target='_blank'>10.1186/s43046-023-00164-5</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s43046-023-00164-5','37032412', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(27);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(27);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s43046-023-00164-5' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(167517);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/27/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/13/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 04/11/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.1186/s43046-023-00164-5" /> <div style="display:none" id="articleAbstract27" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Gastric cancer is a dominant source of cancer-related death around the globe and a serious threat to human health. However, there are very few practical diagnostic approaches and biomarkers for the treatment of this complex disease.</div><div class="abstract-label">METHODS</div><div class="abstract-content">This study aimed to evaluate the association between differentially expressed genes (DEGs), which may function as potential biomarkers, and the diagnosis and treatment of gastric cancer (GC). We constructed a protein-protein interaction network from DEGs followed by network clustering. Members of the two most extensive modules went under the enrichment analysis. We introduced a number of hub genes and gene families playing essential roles in oncogenic pathways and the pathogenesis of gastric cancer. Enriched terms for Biological Process were obtained from the "GO" repository.</div><div class="abstract-label">RESULTS</div><div class="abstract-content">A total of 307 DEGs were identified between GC and their corresponding normal adjacent tissue samples in GSE63089 datasets, including 261 upregulated and 261 downregulated genes. The top five hub genes in the PPI network were CDK1, CCNB1, CCNA2, CDC20, and PBK. They are involved in focal adhesion formation, extracellular matrix remodeling, cell migration, survival signals, and cell proliferation. No significant survival result was found for these hub genes.</div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">Using comprehensive analysis and bioinformatics methods, important key pathways and pivotal genes related to GC progression were identified, potentially informing further studies and new therapeutic targets for GC treatment.</div> <a href="javascript:ShowArticleAbstract(27);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords27" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomarkers%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomarkers</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastric+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastric cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+expression%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene expression</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signaling+networks%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signaling networks</a></li></ul> <a href="javascript:ShowArticleKeywords(27);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh27" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(27);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant27" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(27);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors27" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mousa+Fadaei%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mousa Fadaei</a></li><ul><li>Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Maryam+Kohansal%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Maryam Kohansal</a></li><ul><li>Department of Medical Biotechnology, Fasa University of Medical Sciences, Fasa, Iran<li><li>Department of Biology, Payame Noor University, Tehran, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Omidreza+Akbarpour%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Omidreza Akbarpour</a></li><ul><li>Genetic Laboratory, Fasa University of Medical Sciences, Fasa, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mahsa+Sami%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mahsa Sami</a></li><ul><li>Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ali+Ghanbariasad%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ali Ghanbariasad</a></li><ul><li>Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran.<li><li>Department of Medical Biotechnology, Fasa University of Medical Sciences, Fasa, Iran.<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(27);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow28"> <td style="min-width:40px;text-align:center;"> 28 </td> <td> <div id="citation28" class="article-citation"> <b>Shi X</b>, Li M, Huang Q, Xie L, Huang Z. Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways. <em class='incite-journal-name' onclick='ShowInCiteJournal(324);'>ACS Chem Neurosci</em> 2023;<b>14</b>:1331-1341. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36917811' target='_blank'>36917811</a> DOI: <a href='https://dx.doi.org/10.1021/acschemneuro.3c00104' target='_blank'>10.1021/acschemneuro.3c00104</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1021/acschemneuro.3c00104','36917811', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(28);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(28);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1021/acschemneuro.3c00104' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(324);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/16/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.1021/acschemneuro.3c00104" /> <div style="display:none" id="articleAbstract28" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Monacolin K (MK), a polyketo secondary metabolic compound of the mold genus <i>Monascus</i>, can promote the apoptosis of malignant cancer cells, possessing potential antitumor properties. However, its mechanism of action on gliomas remains unclear. Here, we explored and investigated the potential of the monacolin K's antitumor effect on human glioma U251 cells and its possible molecular mechanism. Results showed that the application of 10 μM monacolin K inhibited the proliferation of U251 cells, with an inhibitory rate of up to 53.4%. Additionally, monacolin K induced the generation of reactive oxygen species and activated mitochondria-mediated pathways, including decreased MMP, activation of caspase3/caspase9, decreased Na<sup>+</sup>/K<sup>+</sup>-ATPase and Ca<sup>2+</sup>-ATPase activities, and disruption of the antioxidant system, resulting in the disruption of intracellular reduction-oxidation homeostasis. Monacolin K also activated MAPK and NF-κB pathways, upregulating P38 activity and downregulating JNK/ERK/P65/IκBα expression, ultimately leading to apoptosis of U251 cells. Importantly, monacolin K was not cytotoxic to normal human cells, hUC-MSCs. We concluded that monacolin K can induce apoptosis in U251 cells by triggering ROS-mediated oxidative damage and regulating MAPKs and NF-κB pathways.</div> <a href="javascript:ShowArticleAbstract(28);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords28" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Monascus%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Monascus</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22antitumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">antitumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22apoptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">apoptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22glioma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">glioma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22intracellular+reduction%e2%88%92oxidation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">intracellular reduction−oxidation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22monacolin+K%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">monacolin K</a></li></ul> <a href="javascript:ShowArticleKeywords(28);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh28" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(28);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant28" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(28);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors28" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xiaoyi+Shi%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xiaoyi Shi</a></li><ul><li>State Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China.,Sino-German Joint Research Institute, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Meng+Li%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Meng Li</a></li><ul><li>State Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China.,Sino-German Joint Research Institute, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Qiming+Huang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Qiming Huang</a></li><ul><li>College of Life Sciences, Nanchang University, No. 999 Xuefu Avenue, Nanchang 330031, China.,The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang 330031, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liuming+Xie%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liuming Xie</a></li><ul><li>State Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China.,Sino-German Joint Research Institute, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zhibing+Huang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zhibing Huang</a></li><ul><li>State Key Laboratory of Food Science and Technology, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China.,Sino-German Joint Research Institute, Nanchang University, No. 235 Nanjing East Road, Nanchang 330047, China<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(28);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow29"> <td style="min-width:40px;text-align:center;"> 29 </td> <td> <div id="citation29" class="article-citation"> <b>Vo D</b>, Ghosh P, Sahoo D. Artificial intelligence-guided discovery of gastric cancer continuum. <em class='incite-journal-name' onclick='ShowInCiteJournal(9419);'>Gastric Cancer</em> 2023;<b>26</b>:286-297. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36692601' target='_blank'>36692601</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871434' target='_blank'>PMC9871434</a> DOI: <a href='https://dx.doi.org/10.1007/s10120-022-01360-3' target='_blank'>10.1007/s10120-022-01360-3</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1007/s10120-022-01360-3','36692601', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(29);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(29);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(29);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(29);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1007/s10120-022-01360-3' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1007/s10120-022-01360-3');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9419);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.editorialmanager.com/gcan' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/16/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/19/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/25/2023]</span></span> </div> <input type="hidden" value="10.1007/s10120-022-01360-3" /> <div style="display:none" id="articleAbstract29" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">Detailed understanding of pre-, early and late neoplastic states in gastric cancer helps develop better models of risk of progression to gastric cancers (GCs) and medical treatment to intercept such progression. </div><div class="abstract-label">METHODS</div><div class="abstract-content">We built a Boolean implication network of gastric cancer and deployed machine learning algorithms to develop predictive models of known pre-neoplastic states, e.g., atrophic gastritis, intestinal metaplasia (IM) and low- to high-grade intestinal neoplasia (L/HGIN), and GC. Our approach exploits the presence of asymmetric Boolean implication relationships that are likely to be invariant across almost all gastric cancer datasets. Invariant asymmetric Boolean implication relationships can decipher fundamental time-series underlying the biological data. Pursuing this method, we developed a healthy mucosa → GC continuum model based on this approach. </div><div class="abstract-label">RESULTS</div><div class="abstract-content">Our model performed better against publicly available models for distinguishing healthy versus GC samples. Although not trained on IM and L/HGIN datasets, the model could identify the risk of progression to GC via the metaplasia → dysplasia → neoplasia cascade in patient samples. The model could rank all publicly available mouse models for their ability to best recapitulate the gene expression patterns during human GC initiation and progression. </div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">A Boolean implication network enabled the identification of hitherto undefined continuum states during GC initiation. The developed model could now serve as a starting point for rationalizing candidate therapeutic targets to intercept GC progression. </div> <a href="javascript:ShowArticleAbstract(29);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords29" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Computational+biology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Computational biology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Machine+learning%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Machine learning</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+neoplasms%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach neoplasms</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Systems+biology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Systems biology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Transcriptome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Transcriptome</a></li></ul> <a href="javascript:ShowArticleKeywords(29);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh29" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <ul><li><a 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href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Metaplasia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Metaplasia</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Precancerous+Conditions%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Precancerous Conditions</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Helicobacter+Infections%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Helicobacter Infections/drug therapy</a></li></ul> <a href="javascript:ShowArticleMeSH(29);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant29" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 CA238042 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIGMS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T32 GM139790 NIGMS NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 CA100768 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 CA160911 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIAID+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 AI155696 NIAID NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIAID+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 AI141630 NIAID NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIGMS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">R01 GM138385 NIGMS NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCATS+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">UG3 TR002968 NCATS NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(29);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors29" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Daniella+Vo%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Daniella Vo</a></li><ul><li>Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, MC 0703, Leichtag Building 132, La Jolla, CA, 92093-0703, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pradipta+Ghosh%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pradipta Ghosh</a></li><ul><li>Moores Cancer Center, University of California San Diego, La Jolla, USA<li><li>Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, USA<li><li>Department of Medicine, University of California San Diego, La Jolla, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Debashis+Sahoo%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Debashis Sahoo</a></li><ul><li>Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, MC 0703, Leichtag Building 132, La Jolla, CA, 92093-0703, USA.<li><li>Moores Cancer Center, University of California San Diego, La Jolla, USA.<li><li>Department of Computer Science and Engineering, Jacob's School of Engineering, University of California San Diego, La Jolla, USA.<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(29);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow30"> <td style="min-width:40px;text-align:center;"> 30 </td> <td> <div id="citation30" class="article-citation"> <b>Liu Q</b>, Gu L, Qiu J, Qian J. Elevated NDC1 expression predicts poor prognosis and correlates with immunity in hepatocellular carcinoma. <em class='incite-journal-name' onclick='ShowInCiteJournal(14031);'>J Gastrointest Oncol</em> 2023;<b>14</b>:245-264. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36915467' target='_blank'>36915467</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10007937' target='_blank'>PMC10007937</a> DOI: <a href='https://dx.doi.org/10.21037/jgo-22-1166' target='_blank'>10.21037/jgo-22-1166</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.21037%2fjgo-22-1166%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 2</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.21037%2fjgo-22-1166')">Impact Index Per Article: 2.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.21037/jgo-22-1166','36915467', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(30);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(30);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.21037/jgo-22-1166' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(14031);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://jgo.amegroups.com/author/submit' target="_blank">Submit a Manuscript</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/25/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 02/02/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 03/02/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.21037/jgo-22-1166" /> <div style="display:none" id="articleAbstract30" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-label">Background</div><div class="abstract-content">NDC1 was identified to be a tumor-promoting factor in non-small cell lung cancer and cervical cancer. However, no report had clarified the relationship between NDC1 and hepatocellular carcinoma (HCC). In this paper, we explored the expression and potential functions of NDC1 in HCC for the first time through the rational application of bioinformatics and relevant basic experiments.</div><div class="abstract-label">Methods</div><div class="abstract-content">NDC1-related expression profiles and clinical data of HCC patients were collected from The Cancer Genome Atlas (TCGA) database, which were verified via quantitative real-time polymerase chain reaction (qRT-PCR), immunohistochemistry and the Clinical Proteomic Tumor Analysis Consortium (CPTAC) database. Univariate and multivariate Cox regression analyses were used to identify NDC1 as an independent factor for HCC prognosis, and NDC1-related signaling pathways were determined by gene set enrichment analysis (GSEA). Furthermore, we deeply probed the potential links of NDC1 to immunity and immune response. Finally, the bioeffects and underlying mechanisms of ectopic NDC1 overexpression and depletion were determined in HepG2 cells by immunoblotting, flow cytometry, Cell-Counting-Kit-8 (CCK-8), and EDU (5-Ethynyl-2'-deoxyuridine).</div><div class="abstract-label">Results</div><div class="abstract-content">Up-regulated expression of NDC1 was detected by means of the TCGA database, which was consistent with the results obtained from further qRT-PCR, immunohistochemistry and the CPTAC database. Kaplan-Meier (K-M) survival analysis revealed a worse prognosis in HCC patients with high NDC1 expression. Besides, NDC1 was certified to be closely linked to tumor histologic grade, clinical stage and T stage. Moreover, univariate and multivariate Cox regression analyses defined NDC1 as an independent element for HCC prognosis. NDC1-related signaling pathways, utilizing GSEA analysis, were subsequently found out. What's more, NDC1 expression was detected to be enormously associated with microsatellite instability (MSI), immune cell infiltration, immune checkpoint molecules and immune cell pathways. As for immunotherapy, we discovered that different risk groups tended to have different immune checkpoint inhibitor responses, which indicated crucial implication value of NDC1 for HCC immunotherapy. More interestingly, we observed that the overexpression of NDC1 could promote the migration and invasion of HCC cells.</div><div class="abstract-label">Conclusions</div><div class="abstract-content">Our article demonstrated that NDC1 might serve as a valuable predictor in the prognosis and immunotherapy of HCC. NDC1 played an oncogenic role in HCC.</div> <a href="javascript:ShowArticleAbstract(30);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords30" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NDC1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">NDC1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22hepatocellular+carcinoma+(HCC)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">hepatocellular carcinoma (HCC)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immunity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immunity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22prognosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">prognosis</a></li></ul> <a href="javascript:ShowArticleKeywords(30);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh30" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(30);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant30" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(30);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors30" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Qingqing+Liu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Qingqing Liu</a></li><ul><li>Department of Gastroenterology, The Second Affiliated Hospital of Nantong University, Nantong, China.,Department of Gastroenterology, The First People's Hospital of Nantong, Nantong, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Liugen+Gu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Liugen Gu</a></li><ul><li>Department of Gastroenterology, The Second Affiliated Hospital of Nantong University, Nantong, China.,Department of Gastroenterology, The First People's Hospital of Nantong, Nantong, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jianwei+Qiu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jianwei Qiu</a></li><ul><li>Department of Gastroenterology, The Second Affiliated Hospital of Nantong University, Nantong, China.,Department of Gastroenterology, The First People's Hospital of Nantong, Nantong, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Junbo+Qian%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Junbo Qian</a></li><ul><li>Department of Gastroenterology, The Second Affiliated Hospital of Nantong University, Nantong, China.,Department of Gastroenterology, The First People's Hospital of Nantong, Nantong, China<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(30);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow31"> <td style="min-width:40px;text-align:center;"> 31 </td> <td> <div id="citation31" class="article-citation"> <b>Javed A</b>, Yarmohammadi M, Korkmaz KS, Rubio-Tomás T. The Regulation of Cyclins and Cyclin-Dependent Kinases in the Development of Gastric Cancer. <em class='incite-journal-name' onclick='ShowInCiteJournal(11724);'>Int J Mol Sci</em> 2023;<b>24</b>:2848. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36769170' target='_blank'>36769170</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9917736' target='_blank'>PMC9917736</a> DOI: <a href='https://dx.doi.org/10.3390/ijms24032848' target='_blank'>10.3390/ijms24032848</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/ijms24032848','36769170', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(31);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(31);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(31);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/ijms24032848' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3390/ijms24032848');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(11724);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/25/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/23/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/28/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/05/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.3390/ijms24032848" /> <div style="display:none" id="articleAbstract31" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Gastric cancer predominantly occurs in adenocarcinoma form and is characterized by uncontrolled growth and metastases of gastric epithelial cells. The growth of gastric cells is regulated by the action of several major cell cycle regulators including Cyclins and Cyclin-dependent kinases (CDKs), which act sequentially to modulate the life cycle of a living cell. It has been reported that inadequate or over-activity of these molecules leads to disturbances in cell cycle dynamics, which consequently results in gastric cancer development. Manny studies have reported the key roles of Cyclins and CDKs in the development and progression of the disease in either in vitro cell culture studies or in vivo models. We aimed to compile the evidence of molecules acting as regulators of both Cyclins and CDKs, i.e., upstream regulators either activating or inhibiting Cyclins and CDKs. The review entails an introduction to gastric cancer, along with an overview of the involvement of cell cycle regulation and focused on the regulation of various Cyclins and CDKs in gastric cancer. It can act as an extensive resource for developing new hypotheses for future studies. </div> <a href="javascript:ShowArticleAbstract(31);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords31" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cyclin-dependent+kinases+(CDKs)%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cyclin-dependent kinases (CDKs)</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cyclins%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cyclins</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cell+cycle+regulation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cell cycle regulation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cell+signaling%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cell signaling</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gastric+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gastric cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22kinases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">kinases</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22molecular+oncology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">molecular oncology</a></li></ul> <a href="javascript:ShowArticleKeywords(31);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh31" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cyclin-Dependent+Kinases%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cyclin-Dependent Kinases/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cyclins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cyclins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cyclins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cyclins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Cycle%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Cycle</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Division%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Division</a></li></ul> <a href="javascript:ShowArticleMeSH(31);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant31" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(31);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors31" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aadil+Javed%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aadil Javed</a></li><ul><li>Department of Bioengineering, Faculty of Engineering, Cancer Biology Laboratory, Ege University, Izmir 35040, Turkey<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mahdieh+Yarmohammadi%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mahdieh Yarmohammadi</a></li><ul><li>Department of Biology, Faculty of Sciences, Central Tehran Branch, Islamic Azad University, Tehran 33817-74895, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Kemal+Sami+Korkmaz%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Kemal Sami Korkmaz</a></li><ul><li>Department of Bioengineering, Faculty of Engineering, Cancer Biology Laboratory, Ege University, Izmir 35040, Turkey<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Teresa+Rubio-Tom%c3%a1s%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Teresa Rubio-Tomás</a></li><ul><li>School of Medicine, University of Crete, 70013 Herakleion, Crete, Greece<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(31);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow32"> <td style="min-width:40px;text-align:center;"> 32 </td> <td> <div id="citation32" class="article-citation"> <b>Qu X</b>, Liu B, Wang L, Liu L, Zhao W, Liu C, Ding J, Zhao S, Xu B, Yu H, Zhang X, Chai J. Loss of cancer-associated fibroblast-derived exosomal DACT3-AS1 promotes malignant transformation and ferroptosis-mediated oxaliplatin resistance in gastric cancer. <em class='incite-journal-name' onclick='ShowInCiteJournal(7942);'>Drug Resist Updat</em> 2023;<b>68</b>:100936. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36764075' target='_blank'>36764075</a> DOI: <a href='https://dx.doi.org/10.1016/j.drup.2023.100936' target='_blank'>10.1016/j.drup.2023.100936</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1016%2fj.drup.2023.100936%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 57</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1016%2fj.drup.2023.100936')">Impact Index Per Article: 57.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.drup.2023.100936','36764075', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(32);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(32);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.drup.2023.100936' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(7942);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/31/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 01/09/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/20/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 02/01/2023]</span></span> </div> <input type="hidden" value="10.1016/j.drup.2023.100936" /> <div style="display:none" id="articleAbstract32" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-label">AIMS</div><div class="abstract-content">Long non-coding RNAs (lncRNAs), as one of the components of exosomes derived from cancer-associated fibroblasts (CAFs), exhibit a crucial role in the pathogenesis and chemoresistance of gastric cancer (GC). Herein, we investigated the role and mechanism of a novel lncRNA disheveled binding antagonist of beta catenin3 antisense1 (DACT3-AS1) and its involvement in GC.</div><div class="abstract-label">METHODS</div><div class="abstract-content">DACT3-AS1 was identified by RNA-sequencing and verified by quantitative reverse transcription polymerase chain reaction (qRT-PCR). The functional role of DACT3-AS1 in GC was evaluated using in vitro and in vivo experiments including Transwell assay, 5-Ethynyl-2'-deoxyuridine (EdU) assay, immunoblotting, and xenograft tumor mouse model. Dual-luciferase reporter assay was performed to assess the association between genes.</div><div class="abstract-label">RESULTS</div><div class="abstract-content">DACT3-AS1 was downregulated and involved in poor prognosis of patients with GC. The results from both in vitro and in vivo experiments showed that DACT3-AS1 suppressed cell proliferation, migration, and invasion through targeting miR-181a-5p/sirtuin 1 (SIRT1) axis. Additionally, DACT3-AS1 was transmitted from CAFs to GC cells mainly via exosomes. Exosomal DACT3-AS1 alleviated xenograft tumor growth. DACT3-AS1 conferred sensitivity of cancer cells to oxaliplatin through SIRT1-mediated ferroptosis both in vitro and in vivo.</div><div class="abstract-label">CONCLUSIONS</div><div class="abstract-content">CAFs-derived exosomal DACT3-AS1 is a suppressive regulator in malignant transformation and oxaliplatin resistance. DACT3-AS1 could be used for diagnosis and treatment of GC.</div> <a href="javascript:ShowArticleAbstract(32);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords32" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DACT3-AS1%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DACT3-AS1</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Exosome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Exosome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ferroptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ferroptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gastric+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gastric cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Oxaliplatin+resistance%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Oxaliplatin resistance</a></li></ul> <a href="javascript:ShowArticleKeywords(32);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh32" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(32);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant32" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(32);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors32" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xianlin+Qu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xianlin Qu</a></li><ul><li>Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bing+Liu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bing Liu</a></li><ul><li>Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Longgang+Wang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Longgang Wang</a></li><ul><li>Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Luguang+Liu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Luguang Liu</a></li><ul><li>Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Weizhu+Zhao%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Weizhu Zhao</a></li><ul><li>Department of Radiology, Shandong University, Shandong Cancer Hospital and Institute, Jinan, Shandong, China; Department of Oncology, Binzhou People's Hospital Affiliated to Shandong First Medical University, Binzhou, Shandong, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Changlei+Liu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Changlei Liu</a></li><ul><li>Department of scientific research project, Shandong Excalibur Medical Research. LTD, Jinan, Shandong, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jishuang+Ding%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jishuang Ding</a></li><ul><li>Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Siwei+Zhao%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Siwei Zhao</a></li><ul><li>Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Botao+Xu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Botao Xu</a></li><ul><li>Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hang+Yu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hang Yu</a></li><ul><li>Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xiang+Zhang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xiang Zhang</a></li><ul><li>Department of scientific research project, Shandong Excalibur Medical Research. LTD, Jinan, Shandong, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jie+Chai%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jie Chai</a></li><ul><li>Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jinan, Shandong, China.<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(32);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow33"> <td style="min-width:40px;text-align:center;"> 33 </td> <td> <div id="citation33" class="article-citation"> Data mining combines bioinformatics discover immunoinfiltration-related gene SERPINE1 as a biomarker for diagnosis and prognosis of stomach adenocarcinoma. <em class='incite-journal-name' onclick='ShowInCiteJournal(20954);'>Sci Rep</em> 2023;<b>13</b>:1373. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36697459' target='_blank'>36697459</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876925' target='_blank'>PMC9876925</a> DOI: <a href='https://dx.doi.org/10.1038/s41598-023-28234-7' target='_blank'>10.1038/s41598-023-28234-7</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1038%2fs41598-023-28234-7%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 8</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1038%2fs41598-023-28234-7')">Impact Index Per Article: 8.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41598-023-28234-7','36697459', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(33);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(33);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41598-023-28234-7' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1038/s41598-023-28234-7');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(20954);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/09/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 01/16/2023]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/27/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.1038/s41598-023-28234-7" /> <div style="display:none" id="articleAbstract33" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Stomach adenocarcinoma (STAD) is a type of cancer which often at itsadvanced stage apon diagnosis and mortality in clinical practice. Several factors influencethe prognosis of STAD, including the expression and regulation of immune cells in the tumor microenvironment. We here investigated the biomarkers related to the diagnosis and prognosis of gastric cancer, hoping to provide insights for the diagnosis and treatment of gastric cancer in the future. STAD and normal patient RNA sequencing data sets were accessed from the cancer genome atlas (TCGA database). Differential genes were determined and obtained by using the R package DESeq2. The stromal, immune, and ESTIMATE scores are calculated by the ESTIMATE algorithm, followed by the modular genes screening using the R package WGCNA. Subsequently, the intersection between the modular gene and the differential gene was taken and the STRING database was used for PPI network module analysis. The R packages clusterProfiler, enrichplot, and ggplot2 were used for GO and KEGG enrichment analysis. Cox regression analysis was used to screen survival-related genes, and finally, the R package Venn Diagram was used to take the intersection and obtain 7 hub genes. The time-dependent ROC curve and Kaplan-Meier survival curve were used to find the SERPINE1 gene, which plays a critical role in prognosis. Finally, the expression pattern, clinical characteristics, and regulatory mechanism of SERPINE1 were analyzed in STAD. We revealed that the expression of SERPINE1 was significantly increased in the samples from STAD compared with normal samples. Cox regression, time-dependent ROC, and Kaplan-Meier survival analyses demonstrated that SERPINE1 was significantly related to the adverse prognosis of STAD patients. The expression of SERPINE1 increased with the progression of T, N, and M classification of the tumor. In addition, the results of immune infiltration analysis indicated that the immune cells' expression were higher in high SERPINE1 expression group than that in low SERPINE1 expression group, including CD4<sup>+</sup> T cells, B cells, CD8<sup>+</sup> T cells, macrophages, neutrophils and other immune cells. SERPINE1 was closely related to immune cells in the STAD immune microenvironment and had a synergistic effect with the immune checkpoints PD1 and PD-L1. In conclusion, we proved that SERPINE1 is a promising prognostic and diagnostic biomarker for STAD and a potential target for immunotherapy.</div> <a href="javascript:ShowArticleAbstract(33);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords33" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bioinformatics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bioinformatics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gene+expression+analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gene expression analysis</a></li></ul> <a href="javascript:ShowArticleKeywords(33);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh33" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(33);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant33" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(33);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors33" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <a href="javascript:ShowArticleAuthors(33);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow34"> <td style="min-width:40px;text-align:center;"> 34 </td> <td> <div id="citation34" class="article-citation"> <b>Petrosyan V</b>, Dobrolecki LE, Thistlethwaite L, Lewis AN, Sallas C, Srinivasan RR, Lei JT, Kovacevic V, Obradovic P, Ellis MJ, Osborne CK, Rimawi MF, Pavlick A, Shafaee MN, Dowst H, Jain A, Saltzman AB, Malovannaya A, Marangoni E, Welm AL, Welm BE, Li S, Wulf GM, Sonzogni O, Huang C, Vasaikar S, Hilsenbeck SG, Zhang B, Milosavljevic A, Lewis MT. Identifying biomarkers of differential chemotherapy response in TNBC patient-derived xenografts with a CTD/WGCNA approach. <em class='incite-journal-name' onclick='ShowInCiteJournal(12734);'>iScience</em> 2023;<b>26</b>:105799. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36619972' target='_blank'>36619972</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9813793' target='_blank'>PMC9813793</a> DOI: <a href='https://dx.doi.org/10.1016/j.isci.2022.105799' target='_blank'>10.1016/j.isci.2022.105799</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1016%2fj.isci.2022.105799%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 13</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1016%2fj.isci.2022.105799')">Impact Index Per Article: 13.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.isci.2022.105799','36619972', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(34);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(34);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(34);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.isci.2022.105799' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/77c652fb49f41090f2dbd74aeb08e15d/main.PMC9813793.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1016/j.isci.2022.105799');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(12734);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 02/28/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/20/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/08/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/14/2022]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.1016/j.isci.2022.105799" /> <div style="display:none" id="articleAbstract34" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Although systemic chemotherapy remains the standard of care for TNBC, even combination chemotherapy is often ineffective. The identification of biomarkers for differential chemotherapy response would allow for the selection of responsive patients, thus maximizing efficacy and minimizing toxicities. Here, we leverage TNBC PDXs to identify biomarkers of response. To demonstrate their ability to function as a preclinical cohort, PDXs were characterized using DNA sequencing, transcriptomics, and proteomics to show consistency with clinical samples. We then developed a network-based approach (CTD/WGCNA) to identify biomarkers of response to carboplatin (MSI1, TMSB15A, ARHGDIB, GGT1, SV2A, SEC14L2, SERPINI1, ADAMTS20, DGKQ) and docetaxel (c, MAGED4, CERS1, ST8SIA2, KIF24, PARPBP). CTD/WGCNA multigene biomarkers are predictive in PDX datasets (RNAseq and Affymetrix) for both taxane- (docetaxel or paclitaxel) and platinum-based (carboplatin or cisplatin) response, thereby demonstrating cross-expression platform and cross-drug class robustness. These biomarkers were also predictive in clinical datasets, thus demonstrating translational potential. </div> <a href="javascript:ShowArticleAbstract(34);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords34" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Immune+response%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Immune response</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Omics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Omics</a></li></ul> <a href="javascript:ShowArticleKeywords(34);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh34" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(34);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant34" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">U54 CA224076 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P50 CA168504 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">U24 CA226110 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NIDA+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">U54 DA036134 NIDA NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P30 CA125123 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">T32 CA203690 NCI NIH HHS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22NCI+NIH+HHS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">P50 CA186784 NCI NIH HHS</a></li></ul> <a href="javascript:ShowArticleGrant(34);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors34" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Varduhi+Petrosyan%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Varduhi Petrosyan</a></li><ul><li>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lacey+E.+Dobrolecki%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lacey E. Dobrolecki</a></li><ul><li>Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lillian+Thistlethwaite%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lillian Thistlethwaite</a></li><ul><li>Quantitative and Computational Biosciences Program, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alaina+N.+Lewis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alaina N. Lewis</a></li><ul><li>Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Christina+Sallas%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Christina Sallas</a></li><ul><li>Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ramakrishnan+R.+Srinivasan%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ramakrishnan R. Srinivasan</a></li><ul><li>Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jonathan+T.+Lei%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jonathan T. Lei</a></li><ul><li>Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vladimir+Kovacevic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vladimir Kovacevic</a></li><ul><li>School of Electrical Engineering, University of Belgrade, Belgrade, Serbia<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Predrag+Obradovic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Predrag Obradovic</a></li><ul><li>School of Electrical Engineering, University of Belgrade, Belgrade, Serbia<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Matthew+J.+Ellis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Matthew J. Ellis</a></li><ul><li>Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA<li><li>Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22C.+Kent+Osborne%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">C. Kent Osborne</a></li><ul><li>Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA<li><li>Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mothaffar+F.+Rimawi%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mothaffar F. Rimawi</a></li><ul><li>Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA<li><li>Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anne+Pavlick%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anne Pavlick</a></li><ul><li>Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Maryam+Nemati+Shafaee%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Maryam Nemati Shafaee</a></li><ul><li>Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Heidi+Dowst%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Heidi Dowst</a></li><ul><li>Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antrix+Jain%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antrix Jain</a></li><ul><li>Mass Spectrometry Proteomics Core, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alexander+B.+Saltzman%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alexander B. Saltzman</a></li><ul><li>Mass Spectrometry Proteomics Core, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anna+Malovannaya%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anna Malovannaya</a></li><ul><li>Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA<li><li>Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA<li><li>Mass Spectrometry Proteomics Core, Baylor College of Medicine, Houston, TX 77030, USA<li><li>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Elisabetta+Marangoni%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Elisabetta Marangoni</a></li><ul><li>Curie Institute, Paris, France<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Alana+L.+Welm%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Alana L. Welm</a></li><ul><li>Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA<li><li>Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bryan+E.+Welm%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bryan E. Welm</a></li><ul><li>Department of Surgery, University of Utah, Salt Lake City, UT 84112, USA<li><li>Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Shunqiang+Li%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Shunqiang Li</a></li><ul><li>Division of Oncology, Washington University, St. Louis, MO 63130, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gerburg+M.+Wulf%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gerburg M. Wulf</a></li><ul><li>Beth Israel Deaconess Medical Center, Boston, MA 02215, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Olmo+Sonzogni%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Olmo Sonzogni</a></li><ul><li>Beth Israel Deaconess Medical Center, Boston, MA 02215, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chen+Huang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chen Huang</a></li><ul><li>Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Suhas+Vasaikar%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Suhas Vasaikar</a></li><ul><li>Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Susan+G.+Hilsenbeck%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Susan G. Hilsenbeck</a></li><ul><li>Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA<li><li>Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bing+Zhang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bing Zhang</a></li><ul><li>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA<li><li>Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA<li><li>Quantitative and Computational Biosciences Program, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aleksandar+Milosavljevic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aleksandar Milosavljevic</a></li><ul><li>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA<li><li>Quantitative and Computational Biosciences Program, Baylor College of Medicine, Houston, TX 77030, USA<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Michael+T.+Lewis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Michael T. Lewis</a></li><ul><li>Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA<li><li>Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA<li><li>Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA<li><li>Department of Radiology, Baylor College of Medicine, Houston, TX, USA<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(34);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow35"> <td style="min-width:40px;text-align:center;"> 35 </td> <td> <div id="citation35" class="article-citation"> <b>Yang M</b>, Wang P, Liu T, Zou X, Xia Y, Li C, Wang X. High throughput sequencing revealed enhanced cell cycle signaling in SLE patients. <em class='incite-journal-name' onclick='ShowInCiteJournal(20954);'>Sci Rep</em> 2023;<b>13</b>:159. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36599883' target='_blank'>36599883</a> DOI: <a href='https://dx.doi.org/10.1038/s41598-022-27310-8' target='_blank'>10.1038/s41598-022-27310-8</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1038%2fs41598-022-27310-8%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 5</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1038%2fs41598-022-27310-8')">Impact Index Per Article: 5.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41598-022-27310-8','36599883', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(35);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(35);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41598-022-27310-8' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(20954);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 07/19/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/29/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/05/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.1038/s41598-022-27310-8" /> <div style="display:none" id="articleAbstract35" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">The multi-system involvement and high heterogeneity of systemic lupus erythematosus (SLE) pose great challenges to its diagnosis and treatment. The purpose of the current study is to identify genes and pathways involved in the pathogenesis of SLE. High throughput sequencing was performed on the PBMCs from SLE patients. We conducted differential gene analysis, gene ontology (GO) analysis, kyoto encyclopedia of genes and genomes (KEGG) analysis, and quantitative real-time PCR (qRT-PCR) verification. Protein-protein interaction (PPI) analysis, alternative splicing analysis, and disease correlation analysis were conducted on some key pathogenic genes as well. Furthermore, si-CDC6 was used for transfection and cell proliferation was monitored using a cell counting kit-8 (CCK-8) assay. We identified 2495 differential genes (1494 upregulated and 1001 downregulated) in SLE patients compared with healthy controls. The significantly upregulated genes were enriched in the biological process-related GO terms of the cell cycle, response to stress, and chromosome organization. KEGG enrichment analysis revealed 7 significantly upregulated pathways including SLE, alcoholism, viral carcinogenesis, cell cycle, proteasome, malaria, and transcriptional misregulation in cancer. We successfully verified some differential genes on the SLE pathway and the cell cycle pathway. CDC6, a key gene in the cell cycle pathway, had remarkably higher MXE alternative splicing events in SLE patients than that in controls, which may explain its significant upregulation in SLE patients. We found that CDC6 participates in the pathogenesis of many proliferation-related diseases and its levels are positively correlated with the severity of SLE. Knockdown of CDC6 suppressed the proliferation of Hela cells and PBMCs from SLE patients in vitro. We identified SLE-related genes and their alternative splicing events. The cell cycle pathway and the cell cycle-related biological processes are over-activated in SLE patients. We revealed a higher incidence of MXE events of CDC6, which may lead to its high expression in SLE patients. Upregulated cell cycle signaling and CDC6 may be related to the hyperproliferation and pathogenesis of SLE. </div> <a href="javascript:ShowArticleAbstract(35);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords35" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(35);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh35" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22HeLa+Cells%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">HeLa Cells</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Signal+Transduction%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Signal Transduction/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Cycle%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Cycle/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lupus+Erythematosus%2c+Systemic%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lupus Erythematosus, Systemic/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lupus+Erythematosus%2c+Systemic%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lupus Erythematosus, Systemic/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22High-Throughput+Nucleotide+Sequencing%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">High-Throughput Nucleotide Sequencing</a></li></ul> <a href="javascript:ShowArticleMeSH(35);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant35" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(35);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors35" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mingyue+Yang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mingyue Yang</a></li><ul><li>Laboratory for Tumor Immunology, Translational Medicine Department, First Hospital of Jilin University, Changchun, 130021, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peisong+Wang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peisong Wang</a></li><ul><li>Thyroid Surgery Department, General Surgery Center, First Hospital of Jilin University, Changchun, 130021, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tao+Liu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tao Liu</a></li><ul><li>Department of Rheumatology and Immunology, First Hospital of Jilin University, Changchun, 130021, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xiaojuan+Zou%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xiaojuan Zou</a></li><ul><li>Department of Rheumatology and Immunology, First Hospital of Jilin University, Changchun, 130021, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ying+Xia%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ying Xia</a></li><ul><li>Laboratory for Tumor Immunology, Translational Medicine Department, First Hospital of Jilin University, Changchun, 130021, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chenxu+Li%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chenxu Li</a></li><ul><li>Laboratory for Tumor Immunology, Translational Medicine Department, First Hospital of Jilin University, Changchun, 130021, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xiaosong+Wang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xiaosong Wang</a></li><ul><li>Laboratory for Tumor Immunology, Translational Medicine Department, First Hospital of Jilin University, Changchun, 130021, China.<li><li>Institute of Translational Medicine, First Hospital of Jilin University, No.519 Dongminzhu Street, Changchun, 130021, China.<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(35);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow36"> <td style="min-width:40px;text-align:center;"> 36 </td> <td> <div id="citation36" class="article-citation"> <b>Araújo D</b>, Ribeiro E, Amorim I, Vale N. Repurposed Drugs in Gastric Cancer. <em>MOLECULES (BASEL, SWITZERLAND)</em> 2022;<b>28</b>:molecules28010319. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36615513' target='_blank'>36615513</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9822219' target='_blank'>PMC9822219</a> DOI: <a href='https://dx.doi.org/10.3390/molecules28010319' target='_blank'>10.3390/molecules28010319</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/molecules28010319','36615513', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(36);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(36);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(36);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/molecules28010319' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3390/molecules28010319');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/01/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 12/21/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 12/25/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/04/2023]</span></span> </div> <input type="hidden" value="10.3390/molecules28010319" /> <div style="display:none" id="articleAbstract36" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Gastric cancer (GC) is one of the major causes of death worldwide, ranking as the fifth most incident cancer in 2020 and the fourth leading cause of cancer mortality. The majority of GC patients are in an advanced stage at the time of diagnosis, presenting a poor prognosis and outcome. Current GC treatment approaches involve endoscopic detection, gastrectomy and chemotherapy or chemoradiotherapy in an adjuvant or neoadjuvant setting. Drug development approaches demand extreme effort to identify molecular mechanisms of action of new drug candidates. Drug repurposing is based on the research of new therapeutic indications of drugs approved for other pathologies. In this review, we explore GC and the different drugs repurposed for this disease.</div> <a href="javascript:ShowArticleAbstract(36);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords36" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22anticancer+drugs%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">anticancer drugs</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gastric+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gastric cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22repurposing+drugs%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">repurposing drugs</a></li></ul> <a href="javascript:ShowArticleKeywords(36);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh36" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%2fdrug+therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms/drug therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%2fpathology%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms/pathology</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoadjuvant+Therapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoadjuvant Therapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chemotherapy%2c+Adjuvant%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chemotherapy, Adjuvant</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Antineoplastic+Combined+Chemotherapy+Protocols%2ftherapeutic+use%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Antineoplastic Combined Chemotherapy Protocols/therapeutic use</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Neoplasm+Staging%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Neoplasm Staging</a></li></ul> <a href="javascript:ShowArticleMeSH(36);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant36" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(36);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors36" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Diana+Ara%c3%bajo%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Diana Araújo</a></li><ul><li>OncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal<li><li>Institute of Biomedical Sciences Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal<li><li>Institute for Research and Innovation in Health (i3S), Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal<li><li>Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Rua Júlio Amaral de Carvalho, 45, 4200-135 Porto, Portugal<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Eduarda+Ribeiro%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Eduarda Ribeiro</a></li><ul><li>OncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal<li><li>Institute of Biomedical Sciences Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Irina+Amorim%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Irina Amorim</a></li><ul><li>Institute of Biomedical Sciences Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal<li><li>Institute for Research and Innovation in Health (i3S), Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal<li><li>Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Rua Júlio Amaral de Carvalho, 45, 4200-135 Porto, Portugal<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nuno+Vale%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nuno Vale</a></li><ul><li>OncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal<li><li>CINTESIS@RISE, Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal<li><li>Department of Community Medicine, Health Information and Decision (MEDCIDS), Faculty of Medicine, University of Porto, Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal<li><li>Correspondence: <email></email>; Tel.: +351-220426537<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(36);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow37"> <td style="min-width:40px;text-align:center;"> 37 </td> <td> <div id="citation37" class="article-citation"> <b>Huang J</b>, Chen M, Pei W, Xu Z, Ning J, Chen C. Distinct tumor microenvironment landscapes in gastric cancer classified by cuproptosis-related lncRNAs. <em class='incite-journal-name' onclick='ShowInCiteJournal(13239);'>J Cancer</em> 2022;<b>13</b>:3687-3700. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36606199' target='_blank'>36606199</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9809317' target='_blank'>PMC9809317</a> DOI: <a href='https://dx.doi.org/10.7150/jca.79640' target='_blank'>10.7150/jca.79640</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.7150%2fjca.79640%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 4</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.7150%2fjca.79640')">Impact Index Per Article: 2.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.7150/jca.79640','36606199', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(37);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(37);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.7150/jca.79640' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.7150/jca.79640');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(13239);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/08/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/20/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/12/2022]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.7150/jca.79640" /> <div style="display:none" id="articleAbstract37" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Cuproptosis is a newly discovered non-apoptotic form of cell death that may be related to the development of tumors. Nonetheless, the potential role of cuproptosis-related lncRNAs in tumor microenvironment (TME) formation and patient-tailored treatment optimization of gastric cancer (GC) is still unclear. In this study, the six-lncRNA signature was constructed to quantify the molecular patterns of GC using LASSO-Cox regression model. Receiver operating characteristic (ROC) curves, C-index curves, independent prognostic analysis and principal component analysis (PCA) were conducted to verify and evaluate the model. The results showed that this risk model was accurate and reliable in predicting GC patient survival. In addition, two distinct subgroups were identified based on the risk model, which showed significant difference in biological functions of the associated genes, TME scores, characteristics of infiltrating immune cells and immunotherapy responses. We found that the high-risk subgroup was associated with immune activation and tumor-related pathways. Furthermore, compared with the low-risk subgroup, the high-risk subgroup had higher TME scores, richer immune cell infiltration and a better immunotherapy response. To accurately identify immune cold tumors and hot tumors, all samples of GC were divided into four distinct clusters by consensus clustering. Among them, Cluster 3 was identified as an immune hot tumor and was more sensitive to immunotherapy. Overall, this study demonstrates that cuproptosis-related lncRNAs could accurately predict the prognosis of patients with GC, help make a distinction between immune cold tumors and hot tumors and provide a basis for the precision medicine of GC.</div> <a href="javascript:ShowArticleAbstract(37);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords37" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22cuproptosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">cuproptosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gastric+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gastric cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immunotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immunotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lncRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lncRNA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22prognosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">prognosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22tumor+microenvironment%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">tumor microenvironment</a></li></ul> <a href="javascript:ShowArticleKeywords(37);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh37" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(37);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant37" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(37);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors37" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jianfeng+Huang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jianfeng Huang</a></li><ul><li>Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218 JiXi Avenue, Hefei 230022, Anhui, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Meixiang+Chen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Meixiang Chen</a></li><ul><li>The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wenguang+Pei%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wenguang Pei</a></li><ul><li>Department of Gastrointestinal Surgery, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zhijue+Xu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zhijue Xu</a></li><ul><li>Department of Vascular Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.,✉ Corresponding authors: <bold>Zhijue Xu,</bold> Department of Vascular Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. E-mail: <email></email>;<bold> Jie Ning,</bold> Department of Oncology, The First Affiliated Hospital of Anhui Medical University, 218 JiXi Avenue, Hefei 230022, Anhui, China. E-mail: <email></email>; <bold>Changyu Chen,</bold> Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218 JiXi Avenue, Hefei 230022, Anhui, China. E-mail: <email></email><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jie+Ning%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jie Ning</a></li><ul><li>Department of Oncology, The First Affiliated Hospital of Anhui Medical University, 218 JiXi Avenue, Hefei 230022, Anhui, China.,✉ Corresponding authors: <bold>Zhijue Xu,</bold> Department of Vascular Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. E-mail: <email></email>;<bold> Jie Ning,</bold> Department of Oncology, The First Affiliated Hospital of Anhui Medical University, 218 JiXi Avenue, Hefei 230022, Anhui, China. E-mail: <email></email>; <bold>Changyu Chen,</bold> Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218 JiXi Avenue, Hefei 230022, Anhui, China. E-mail: <email></email><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Changyu+Chen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Changyu Chen</a></li><ul><li>Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218 JiXi Avenue, Hefei 230022, Anhui, China.,✉ Corresponding authors: <bold>Zhijue Xu,</bold> Department of Vascular Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. E-mail: <email></email>;<bold> Jie Ning,</bold> Department of Oncology, The First Affiliated Hospital of Anhui Medical University, 218 JiXi Avenue, Hefei 230022, Anhui, China. E-mail: <email></email>; <bold>Changyu Chen,</bold> Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, 218 JiXi Avenue, Hefei 230022, Anhui, China. E-mail: <email></email><li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(37);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow38"> <td style="min-width:40px;text-align:center;"> 38 </td> <td> <div id="citation38" class="article-citation"> <b>Badie A</b>, Gaiddon C, Mellitzer G. Histone Deacetylase Functions in Gastric Cancer: Therapeutic Target? <em class='incite-journal-name' onclick='ShowInCiteJournal(4622);'>Cancers (Basel)</em> 2022;<b>14</b>:5472. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36358890' target='_blank'>36358890</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9659209' target='_blank'>PMC9659209</a> DOI: <a href='https://dx.doi.org/10.3390/cancers14215472' target='_blank'>10.3390/cancers14215472</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3390%2fcancers14215472%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 2</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3390%2fcancers14215472')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/cancers14215472','36358890', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(38);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(38);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/cancers14215472' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4622);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 10/07/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 10/29/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 11/01/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 09/05/2023]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.3390/cancers14215472" /> <div style="display:none" id="articleAbstract38" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Gastric cancer (GC) is one of the most aggressive cancers. Therapeutic treatments are based on surgery combined with chemotherapy using a combination of platinum-based agents. However, at metastatic stages of the disease, survival is extremely low due to late diagnosis and resistance mechanisms to chemotherapies. The development of new classifications has not yet identified new prognostic markers for clinical use. The studies of epigenetic processes highlighted the implication of histone acetylation status, regulated by histone acetyltransferases (HATs) and by histone deacetylases (HDACs), in cancer development. In this way, inhibitors of HDACs (HDACis) have been developed and some of them have already been clinically approved to treat T-cell lymphoma and multiple myeloma. In this review, we summarize the regulations and functions of eighteen HDACs in GC, describing their known targets, involved cellular processes, associated clinicopathological features, and impact on survival of patients. Additionally, we resume the in vitro, pre-clinical, and clinical trials of four HDACis approved by Food and Drug Administration (FDA) in cancers in the context of GC. </div> <a href="javascript:ShowArticleAbstract(38);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords38" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22biomarker%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">biomarker</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gastric+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gastric cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22histone+deacetylase%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">histone deacetylase</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22histone+deacetylase+inhibitor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">histone deacetylase inhibitor</a></li></ul> <a href="javascript:ShowArticleKeywords(38);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh38" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(38);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant38" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(38);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors38" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Amandine+Badie%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Amandine Badie</a></li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Christian+Gaiddon%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Christian Gaiddon</a></li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Georg+Mellitzer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Georg Mellitzer</a></li><ul><li>Laboratoire Streinth, Université de Strasbourg, Inserm UMR_S 1113 IRFAC, 67200 Strasbourg, France<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(38);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow39"> <td style="min-width:40px;text-align:center;"> 39 </td> <td> <div id="citation39" class="article-citation"> Non-coding genome in small cell lung cancer between theoretical view and clinical applications. <em class='incite-journal-name' onclick='ShowInCiteJournal(20984);'>Semin Cancer Biol</em> 2022;<b>86</b>:237-250. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/35367369' target='_blank'>35367369</a> DOI: <a href='https://dx.doi.org/10.1016/j.semcancer.2022.03.024' target='_blank'>10.1016/j.semcancer.2022.03.024</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1016%2fj.semcancer.2022.03.024%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 5</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1016%2fj.semcancer.2022.03.024')">Impact Index Per Article: 2.5</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.semcancer.2022.03.024','35367369', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(39);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(39);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.semcancer.2022.03.024' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(20984);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/31/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 03/22/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 03/26/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/27/2023]</span></span> </div> <input type="hidden" value="10.1016/j.semcancer.2022.03.024" /> <div style="display:none" id="articleAbstract39" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Small cell lung cancer (SCLC) is a highly aggressive cancer of the neuroendocrine system, characterized by poor differentiation, rapid growth, and poor overall survival (OS) of patients. Despite the recent advances in the treatment of SCLC recently, the 2-year survival rate of patients with the cancer is only 14-15%, occasioned by the acquired resistance to drugs and serious off-target effects. In humans, the coding region is only 2% of the total genome, and 20% of that is associated with human diseases. Beyond the coding genome are RNAs, promoters, enhancers, and other intricate elements. The non-coding regulatory regions, mainly the non-coding RNAs (ncRNAs), regulate numerous biological activities including cell proliferation, metastasis, and drug resistance. As such, they are potential diagnostic or prognostic biomarkers, and also potential therapeutic targets for SCLC. Therefore, understanding how non-coding elements regulate SCLC development and progression holds significant clinical implications. Herein, we summarized the recent discoveries on the relationship between the non-coding elements including long non-coding RNAs (lncRNA), microRNAs (miRNAs), circular RNA (circRNA), enhancers as well as promotors, and the pathogenesis of SCLC and their potential clinical applications.</div> <a href="javascript:ShowArticleAbstract(39);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords39" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Enhancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Enhancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Non-coding+RNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Non-coding RNA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Non-coding+genome%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Non-coding genome</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Promoter%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Promoter</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Small+cell+lung+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Small cell lung cancer</a></li></ul> <a href="javascript:ShowArticleKeywords(39);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh39" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(39);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant39" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(39);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors39" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <a href="javascript:ShowArticleAuthors(39);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow40"> <td style="min-width:40px;text-align:center;"> 40 </td> <td> <div id="citation40" class="article-citation"> <b>Bai Y</b>, Qu D, Lu D, Li Y, Zhao N, Cui G, Li X, Sun X, Sun H, Zhao L, Li Q, Zhang Q, Han T, Wang S, Yang Y. Pan-cancer landscape of abnormal ctDNA methylation across human tumors. <em class='incite-journal-name' onclick='ShowInCiteJournal(4461);'>Cancer Genet</em> 2022;<b>268-269</b>:37-45. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36152512' target='_blank'>36152512</a> DOI: <a href='https://dx.doi.org/10.1016/j.cancergen.2022.09.005' target='_blank'>10.1016/j.cancergen.2022.09.005</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1016/j.cancergen.2022.09.005','36152512', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(40);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(40);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1016/j.cancergen.2022.09.005' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4461);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 12/21/2021]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/25/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/12/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 01/25/2023]</span></span> </div> <input type="hidden" value="10.1016/j.cancergen.2022.09.005" /> <div style="display:none" id="articleAbstract40" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-label">BACKGROUND</div><div class="abstract-content">The aim of this paper is to explore the correlation between circulating tumor DNA (ctDNA) methylation and mutations and its value in clinical early cancer screening.</div><div class="abstract-label">METHODS</div><div class="abstract-content">We performed target region methylation sequencing and genome sequencing on plasma samples. Methylation models to distinguish cancer from healthy individuals have been developed using hypermethylated genes in tumors and validated in training set and prediction set.</div><div class="abstract-label">RESULTS</div><div class="abstract-content">We found that patients with cancer had higher levels of ctDNA methylation compared to healthy individuals. The level of ctDNA methylation in cell cycle, p53, Notch pathway in pan-cancer was significantly correlated with the number of mutations, and mutation frequency. Methylation burden in some tumors was significantly correlated with tumor mutational burden (TMB), microsatellite instability (MSI) and PD-L1. The ctDNA methylation differences in cancer patients were mainly concentrated in the Herpes simplex virus 1 infection pathway. The area under curve (AUC) of the training and prediction sets of the methylation model distinguishing cancer from healthy individuals were 0.93 and 0.92, respectively.</div><div class="abstract-label">CONCLUSION</div><div class="abstract-content">Our study provides a landscape of methylation levels of important pathways in pan-cancer. ctDNA methylation significantly correlates with mutation type, frequency and number, providing a reference for clinical application of ctDNA methylation in early cancer screening.</div> <a href="javascript:ShowArticleAbstract(40);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords40" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Circulating+tumor+DNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Circulating tumor DNA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Epigenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Epigenetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Methylation+model%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Methylation model</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pan-cancer+analysis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pan-cancer analysis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pathway%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pathway</a></li></ul> <a href="javascript:ShowArticleKeywords(40);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh40" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(40);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant40" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(40);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors40" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yun+Bai%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yun Bai</a></li><ul><li>Department of Medical Oncology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Di+Qu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Di Qu</a></li><ul><li>Department of Medical Oncology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Dan+Lu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Dan Lu</a></li><ul><li>Department of Medical Oncology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yiwen+Li%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yiwen Li</a></li><ul><li>Department of Medical Oncology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ning+Zhao%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ning Zhao</a></li><ul><li>Department of Medical Oncology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Guanghua+Cui%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Guanghua Cui</a></li><ul><li>Department of Medical Oncology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xue+Li%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xue Li</a></li><ul><li>Department of Medical Oncology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xiaoke+Sun%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xiaoke Sun</a></li><ul><li>Department of Medical Oncology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Huaibo+Sun%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Huaibo Sun</a></li><ul><li>Genecast Biotechnology Co., Ltd, Wuxi 214104, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lihua+Zhao%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lihua Zhao</a></li><ul><li>Genecast Biotechnology Co., Ltd, Wuxi 214104, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Qingyuan+Li%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Qingyuan Li</a></li><ul><li>Genecast Biotechnology Co., Ltd, Wuxi 214104, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Qi+Zhang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Qi Zhang</a></li><ul><li>Genecast Biotechnology Co., Ltd, Wuxi 214104, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tiancheng+Han%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tiancheng Han</a></li><ul><li>Genecast Biotechnology Co., Ltd, Wuxi 214104, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Song+Wang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Song Wang</a></li><ul><li>Department of Medical Oncology, Mudanjiang Cancer Hospital, Mudanjiang 157009, China.<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yu+Yang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yu Yang</a></li><ul><li>Department of Medical Oncology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China.<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(40);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow41"> <td style="min-width:40px;text-align:center;"> 41 </td> <td> <div id="citation41" class="article-citation"> <b>Ghafouri-Fard S</b>, Khoshbakht T, Hussen BM, Dong P, Gassler N, Taheri M, Baniahmad A, Dilmaghani NA. A review on the role of cyclin dependent kinases in cancers. <em class='incite-journal-name' onclick='ShowInCiteJournal(4451);'>Cancer Cell Int</em> 2022;<b>22</b>:325. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36266723' target='_blank'>36266723</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583502' target='_blank'>PMC9583502</a> DOI: <a href='https://dx.doi.org/10.1186/s12935-022-02747-z' target='_blank'>10.1186/s12935-022-02747-z</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1186%2fs12935-022-02747-z%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 41</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1186%2fs12935-022-02747-z')">Impact Index Per Article: 20.5</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s12935-022-02747-z','36266723', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(41);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(41);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s12935-022-02747-z' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/c48f00b9ae234fb9e86079160693bb01/PMC9583502.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1186/s12935-022-02747-z');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(4451);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 08/24/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 10/07/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/16/2022]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.1186/s12935-022-02747-z" /> <div style="display:none" id="articleAbstract41" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <p>The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers. The expression of CDKs is controlled by a complex regulatory network comprised of genetic and epigenetic mechanisms, which are dysregulated during the progression of cancer. The abnormal activation of CDKs results in uncontrolled cancer cell proliferation and the induction of cancer stem cell characteristics. The levels of CDKs can be utilized to predict the prognosis and treatment response of cancer patients, and further understanding of the function and underlying mechanisms of CDKs in human tumors would pave the way for future cancer therapies that effectively target CDKs. Defects in the regulation of cell cycle and mutations in the genes coding cell-cycle regulatory proteins lead to unrestrained proliferation of cells leading to formation of tumors. A number of treatment modalities have been designed to combat dysregulation of cell cycle through affecting expression or activity of CDKs. However, effective application of these methods in the clinical settings requires recognition of the role of CDKs in the progression of each type of cancer, their partners, their interactions with signaling pathways and the effects of suppression of these kinases on malignant features. Thus, we designed this literature search to summarize these findings at cellular level, as well as in vivo and clinical levels. </p> <a href="javascript:ShowArticleAbstract(41);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords41" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22CDK%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">CDK</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cyclin+dependent+kinases%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cyclin dependent kinases</a></li></ul> <a href="javascript:ShowArticleKeywords(41);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh41" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(41);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant41" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(41);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors41" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Soudeh+Ghafouri-Fard%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Soudeh Ghafouri-Fard</a></li><ul><li>Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tayyebeh+Khoshbakht%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tayyebeh Khoshbakht</a></li><ul><li>Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Bashdar+Mahmud+Hussen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Bashdar Mahmud Hussen</a></li><ul><li>Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq.,Center of Research and Strategic Studies, Lebanese French University, Erbil, Kurdistan Region, Iraq<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Peixin+Dong%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Peixin Dong</a></li><ul><li>Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Hokkaido University, Sapporo, Japan<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nikolaus+Gassler%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nikolaus Gassler</a></li><ul><li>Section of Pathology, Institute of Forensic Medicine, Jena University Hospital, Jena, Germany<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mohammad+Taheri%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mohammad Taheri</a></li><ul><li>Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. .,Institute of Human Genetics, Jena University Hospital, Jena, Germany.<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aria+Baniahmad%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aria Baniahmad</a></li><ul><li>Institute of Human Genetics, Jena University Hospital, Jena, Germany.<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Nader+Akbari+Dilmaghani%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Nader Akbari Dilmaghani</a></li><ul><li>Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(41);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow42"> <td style="min-width:40px;text-align:center;"> 42 </td> <td> <div id="citation42" class="article-citation"> <b>Zafar J</b>, Huang J, Xu X, Jin F. Analysis of Long Non-Coding RNA-Mediated Regulatory Networks of <i>Plutella xylostella</i> in Response to <i>Metarhizium anisopliae</i> Infection. <em>INSECTS</em> 2022;<b>13</b>:916. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36292864' target='_blank'>36292864</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9604237' target='_blank'>PMC9604237</a> DOI: <a href='https://dx.doi.org/10.3390/insects13100916' target='_blank'>10.3390/insects13100916</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3390%2finsects13100916%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 2</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3390%2finsects13100916')">Impact Index Per Article: 1.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3390/insects13100916','36292864', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(42);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(42);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3390/insects13100916' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3390/insects13100916');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 09/15/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 09/30/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 09/30/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 06/16/2023]</span></span> </div> <input type="hidden" value="10.3390/insects13100916" /> <div style="display:none" id="articleAbstract42" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-content">Long non-coding RNAs (lncRNAs) represent a diverse class of RNAs that are structurally similar to messenger RNAs (mRNAs) but do not encode proteins. Growing evidence suggests that in response to biotic and abiotic stresses, the lncRNAs play crucial regulatory roles in plants and animals. However, the potential role of lncRNAs during fungal infection has yet to be characterized in <i>Plutella xylostella</i>, a devastating pest of cruciferous crops. In the current study, we performed a strand-specific RNA sequencing of <i>Metarhizium anisopliae</i>-infected (Px36hT, Px72hT) and uninfected (Px36hCK, Px72hCK) <i>P. xylostella</i> fat body tissues. Comprehensive bioinformatic analysis revealed a total of 5665 and 4941 lncRNAs at 36 and 72-h post-infection (hpi), including 563 (Px36hT), 532 (Px72hT) known and 5102 (Px36hT), 4409 (Px72hT) novel lncRNA transcripts. These lncRNAs shared structural similarities with their counterparts in other species, including shorter exon and intron length, fewer exon numbers, and a lower expression profile than mRNAs. LncRNAs regulate the expression of neighboring protein-coding genes by acting in a <i>cis</i> and <i>trans</i> manner. Functional annotation and pathway analysis of <i>cis</i>-acting lncRNAs revealed their role in several immune-related genes, including <i>Toll</i>, <i>serpin</i>, <i>transferrin</i>, <i>βGRP</i> etc. Furthermore, we identified multiple lncRNAs acting as microRNA (miRNA) precursors. These miRNAs can potentially regulate the expression of mRNAs involved in immunity and development, suggesting a crucial lncRNA-miRNA-mRNA complex. Our findings will provide a genetic resource for future functional studies of lncRNAs involved in <i>P. xylostella</i> immune responses to <i>M. anisopliae</i> infection and shed light on understanding insect host-pathogen interactions.</div> <a href="javascript:ShowArticleAbstract(42);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords42" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22bio-control%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">bio-control</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22entomopathogenic+fungus%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">entomopathogenic fungus</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22fat+body%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">fat body</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22host%e2%80%93pathogen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">host–pathogen</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22insect+immunity%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">insect immunity</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lepidoptera%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lepidoptera</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lncRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lncRNA</a></li></ul> <a href="javascript:ShowArticleKeywords(42);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh42" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(42);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant42" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(42);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors42" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Junaid+Zafar%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Junaid Zafar</a></li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Junlin+Huang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Junlin Huang</a></li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xiaoxia+Xu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xiaoxia Xu</a></li><ul><li>Correspondence: <email></email> (X.X.); <email></email> (F.J.); Tel.: +86-135-6047-8369 (F.J.)<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Fengliang+Jin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Fengliang Jin</a></li><ul><li>Correspondence: <email></email> (X.X.); <email></email> (F.J.); Tel.: +86-135-6047-8369 (F.J.)<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(42);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow43"> <td style="min-width:40px;text-align:center;"> 43 </td> <td> <div id="citation43" class="article-citation"> <b>Liang L</b>, Cen H, Huang J, Qin A, Xu W, Wang S, Chen Z, Tan L, Zhang Q, Yu X, Yang X, Zhang L. The reversion of DNA methylation-induced miRNA silence via biomimetic nanoparticles-mediated gene delivery for efficient lung adenocarcinoma therapy. <em class='incite-journal-name' onclick='ShowInCiteJournal(17401);'>Mol Cancer</em> 2022;<b>21</b>:186. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36171576' target='_blank'>36171576</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9516831' target='_blank'>PMC9516831</a> DOI: <a href='https://dx.doi.org/10.1186/s12943-022-01651-4' target='_blank'>10.1186/s12943-022-01651-4</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1186%2fs12943-022-01651-4%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 16</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1186%2fs12943-022-01651-4')">Impact Index Per Article: 8.0</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1186/s12943-022-01651-4','36171576', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(43);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(43);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1186/s12943-022-01651-4' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/6aceb70fc9741abc9f81c122abc6c5a5/PMC9516831.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1186/s12943-022-01651-4');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(17401);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/24/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/25/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/21/2022]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.1186/s12943-022-01651-4" /> <div style="display:none" id="articleAbstract43" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-label">Background</div><p>Lung cancer is one of the fatal cancers worldwide, and over 60% of patients are lung adenocarcinoma (LUAD). Our clinical data demonstrated that DNA methylation of the promoter region of miR-126-3p was upregulated, which led to the decreased expression of miR-126-3p in 67 cases of lung cancer tissues, implying that miR-126-3p acted as a tumor suppressor. Transduction of miR-126-3p is a potential therapeutic strategy for treating LUAD, yet the physiological environment and properties of miRNA challenge current transduction approaches.</p><div class="abstract-label">Methods</div><p>We evaluated the expression of miR-126-3p in 67 pairs of lung cancer tissues and the corresponding adjacent non-tumorous tissues by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The relationship between the overall survival of lung cancer patients and miR-126-3p was analyzed by the Cancer Genome Atlas cohort database (Oncolnc, <ext-link ext-link-type="uri" xlink:href="http://www.oncolnc.org" xmlns:xlink="http://www.w3.org/1999/xlink">http://www.oncolnc.org</ext-link>). We analyzed DNA methylation Methylation-specific PCR (MSP) analysis. To determine whether ADAM9 is the direct target of miR-126-3p, we performed the 3′-UTR luciferase reporter assay. The protein levels in the cells or tissues were evaluated with western blotting (WB) analysis. The biodistribution of nanoparticles were monitored by in vivo tracking system.</p><div class="abstract-label">Results</div><p>We describe the development of novel stealth and matrix metalloproteinase 2 (MMP2)-activated biomimetic nanoparticles, which are constructed using MMP2-responsive peptides to bind the miR-126-3p (known as MAIN), and further camouflaged with red blood cell (RBC) membranes (hence named REMAIN). REMAIN was able to effectively transduce miRNA into lung cancer cells and release them via MMP2 responsiveness. Additionally, REMAIN possessed the advantages of the natural RBC membrane, including extended circulation time, lower toxicity, better biocompatibility, and immune escape. Moreover, in vitro and in vivo results demonstrated that REMAIN effectively induced apoptosis of lung cancer cells and inhibited LUAD development and progression by targeting ADAM9.</p><div class="abstract-label">Conclusion</div><p>The novel style of stealth and MMP2-activated biomimetic nanoparticles show great potential in miRNA delivery.</p><div class="abstract-label">Supplementary Information</div><p>The online version contains supplementary material available at 10.1186/s12943-022-01651-4.</p> <a href="javascript:ShowArticleAbstract(43);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords43" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Biomimetic+nanoparticles%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Biomimetic nanoparticles</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DNA+methylation%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DNA methylation</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lung+adenocarcinoma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lung adenocarcinoma</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MMP2%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MMP2</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22MicroRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">MicroRNA</a></li></ul> <a href="javascript:ShowArticleKeywords(43);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh43" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(43);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant43" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(43);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors43" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lu+Liang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lu Liang</a></li><ul><li>Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Huiyu+Cen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Huiyu Cen</a></li><ul><li>Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jionghua+Huang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jionghua Huang</a></li><ul><li>Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, China.,Department of Cardiovascular Disease, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Aiping+Qin%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Aiping Qin</a></li><ul><li>Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wenyan+Xu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wenyan Xu</a></li><ul><li>Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Siran+Wang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Siran Wang</a></li><ul><li>Department of Preventive Dentistry, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Affiliated Stomatology Hospital of Guangzhou Medical University, 510182, Guangzhou, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zhijun+Chen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zhijun Chen</a></li><ul><li>Department of Medical Imaging, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, 510095, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lin+Tan%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lin Tan</a></li><ul><li>Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Qiqi+Zhang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Qiqi Zhang</a></li><ul><li>Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xiyong+Yu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xiyong Yu</a></li><ul><li>Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, China.<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xin+Yang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xin Yang</a></li><ul><li>Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, China.<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lingmin+Zhang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lingmin Zhang</a></li><ul><li>Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, China.<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(43);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow44"> <td style="min-width:40px;text-align:center;"> 44 </td> <td> <div id="citation44" class="article-citation"> miR-187/PDLIM1 Gets Involved in Gastric Cancer Progression and Cisplatin Sensitivity of Cisplatin by Mediating the Hippo-YAP Signaling Pathway. <em>JOURNAL OF ONCOLOGY</em> 2022;<b>2022</b>:5456016. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36164345' target='_blank'>36164345</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509220' target='_blank'>PMC9509220</a> DOI: <a href='https://dx.doi.org/10.1155/2022/5456016' target='_blank'>10.1155/2022/5456016</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1155/2022/5456016','36164345', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(44);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1155/2022/5456016' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/306c3e461ad7a249d9e7ab9e3cf0926d/PMC9509220.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1155/2022/5456016');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/27/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 07/30/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/04/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/22/2022]</span></span> </div> <input type="hidden" value="10.1155/2022/5456016" /> <div style="display:none" id="articleAbstract44" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <p>Gastric cancer (GC) is one of the most prevalent malignancies in the digestive system across the world. The function and mechanism of PDLIM1, a cancer-suppressing gene, in gastric cancer progression remain unclear. This study is aimed at investigating the expression features and function of PDLIM1 in GC. RT-qPCR and western blot were used to compare the profiles of PDLIM1 and miR-187 between GC and normal tissues. The cell models of PDLIM1 overexpression and low expression were established in gastric cancer cell lines MKN45 and AGS. CCK8 and BrdU assays measured cell proliferation. Flow cytometry monitored cell apoptosis. Transwell analyzed cell invasion and migration. The influence of miR-187 overexpression on gastric cancer development was assessed. We predicted the targeted correlation between miR-187 and PDLIM1 through bioinformatics, which was corroborated via dual luciferase activity assay and RIP. Meanwhile, the cell model of PDLIM1 overexpression was built in AGS cells transfected with miR-187 mimics. A rescue experiment was conducted to assess the impact of PDLIM1 overexpression on the procancer function of miR-187. As a result, in contrast with normal paracancer tissues, PDLIM1 was substantially downregulated in GC tissues. Moreover, PDLIM1 overexpression considerably dampened proliferation, invasion, and migration in GC cells, boosted the cell apoptosis, and bolstered their sensitivity to cisplatin. PDLIM1 knockdown or miR-187 overexpression dramatically fostered GC cell proliferation, invasion, and migration and repressed cell apoptosis. Mechanism studies demonstrated that PDLIM1 vigorously restrained the profiles of the Hippo-YAP signaling pathway and the downstream target genes. miR-187 targeted PDLIM1, while miR-187 overexpression cramped PDLIM1 expression. The rescue experiment suggested that PDLIM1 overexpression weakened the procancer function of miR-187 in GC cells. In conclusion, our study demonstrated that PDLIM1 presented a low expression in GC tissues, while miR-187/PDLIM1 participated in GC development and cisplatin sensitivity by mediating the Hippo-YAP signaling pathway.</p> <a href="javascript:ShowArticleAbstract(44);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords44" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(44);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh44" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(44);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant44" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(44);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors44" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <a href="javascript:ShowArticleAuthors(44);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow45"> <td style="min-width:40px;text-align:center;"> 45 </td> <td> <div id="citation45" class="article-citation"> A DCS-related lncRNA signature predicts the prognosis and chemotherapeutic response of patients with gastric cancer. <em class='incite-journal-name' onclick='ShowInCiteJournal(3705);'>Biosci Rep</em> 2022;<b>42</b>:231674. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/35993308' target='_blank'>35993308</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9446389' target='_blank'>PMC9446389</a> DOI: <a href='https://dx.doi.org/10.1042/bsr20220989' target='_blank'>10.1042/bsr20220989</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1042%2fbsr20220989%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1042%2fbsr20220989')">Impact Index Per Article: 0.5</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1042/bsr20220989','35993308', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(45);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleKeywords(45);" target='_self'>Key Words</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1042/bsr20220989' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/b8c420d38d65dc44134e2ee6b69e6d9a/PMC9446389.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1042/bsr20220989');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(3705);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/04/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 08/10/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/19/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/21/2022]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.1042/bsr20220989" /> <div style="display:none" id="articleAbstract45" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <p>The combination of docetaxel, cisplatin, and S-1 (DCS) is a common chemotherapy regimen for patients with gastric cancer (GC). However, studies on long noncoding RNAs (lncRNAs) associated with the chemotherapeutic response to and prognosis after DCS remain lacking. The aim of the present study was to identify DCS mRNAs-lncRNAs associated with chemotherapy response and prognosis in GC patients. In the present study, we identified 548 lncRNAs associated with these 16 mRNAs in the TCGA and GSE31811 datasets. Eleven lncRNAs were used to construct a prognostic signature by least absolute shrinkage and selection operator (LASSO) regression. A model including the 11 lncRNAs (LINC02532, AC007277.1, AC005324.4, AL512506.1, AC068790.7, AC022509.2, AC113139.1, LINC00106, AC005165.1, MIR100HG, and UBE2R2-AS1) associated with the prognosis of GC was constructed. The signature was validated in the TCGA database, model comparison, and qRT-PCR experiments. The results showed that the risk signature was a more effective prognostic factor for GC patients. Furthermore, the results showed that this model can well predicting chemotherapy drug response and immune infiltration of GC patients. In addition, our experimental results indicated that lower expression levels of LINC00106 and UBE2R2-AS1 predicted worse drug resistance in AGS/DDP cells. The experimental results agreed with the predictions. Furthermore, knockdown of LINC00106 or UBE2R2-AS1 can significantly enhanced the proliferation and migration of GC AGS cells <italic toggle="yes">in vitro</italic>. In conclusion, a novel DCS therapy-related lncRNA signature may become a new strategy to predict chemotherapy response and prognosis in GC patients. LINC00106 and UBE2R2-AS1 may exhibit a tumor suppressive function in GC.</p> <a href="javascript:ShowArticleAbstract(45);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords45" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22DCS%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">DCS</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22chemotherapy%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">chemotherapy</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22gastric+cancer%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">gastric cancer</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22immune+infiltration%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">immune infiltration</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22lncRNA%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">lncRNA</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22kw%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22prognosis+signature%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">prognosis signature</a></li></ul> <a href="javascript:ShowArticleKeywords(45);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh45" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(45);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant45" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(45);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors45" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <a href="javascript:ShowArticleAuthors(45);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow46"> <td style="min-width:40px;text-align:center;"> 46 </td> <td> <div id="citation46" class="article-citation"> <b>Cheng Z</b>, Guo Y, Sun J, Zheng L. Four-copy number alteration (CNA)-related lncRNA prognostic signature for liver cancer. <em class='incite-journal-name' onclick='ShowInCiteJournal(20954);'>Sci Rep</em> 2022;<b>12</b>:14261. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/35995822' target='_blank'>35995822</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395537' target='_blank'>PMC9395537</a> DOI: <a href='https://dx.doi.org/10.1038/s41598-022-17927-0' target='_blank'>10.1038/s41598-022-17927-0</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.1038%2fs41598-022-17927-0%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.1038%2fs41598-022-17927-0')">Impact Index Per Article: 0.5</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1038/s41598-022-17927-0','35995822', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(46);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1038/s41598-022-17927-0' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/9adb527ae2afe3b1a2c34cb2e20feff3/PMC9395537.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1038/s41598-022-17927-0');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(20954);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 03/23/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 08/02/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/26/2022]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.1038/s41598-022-17927-0" /> <div style="display:none" id="articleAbstract46" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <p>The objective of this study was to identify CNA-related lncRNAs that can better evaluate the prognosis of patients with liver cancer. Prognostic molecular subtypes were identified, followed by tumor mutation and differential expression analyses. Genomic copy number anomalies and their association with lncRNAs were also evaluated. A risk model was built based on lncRNAs, as well as a nomogram, and the differences in the tumor immune microenvironment and drug sensitivity between the High_ and Low_risk groups were compared. Weighted gene co-expression network analysis was used to identify modules with significant enrichment in prognostic-related lncRNAs. In total, two subtypes were identified, <italic>TP53</italic> and <italic>CTNNB1</italic> were common high-frequency mutated genes in the two subtypes. A total of 8,372 differentially expressed (DE) mRNAs and 798 DElncRNAs were identified between cluster1 and cluster2. In addition, a four-lncRNA signature was constructed, and statistically significant differences between the Low_ and High_risk groups were found in terms of CD8 T cells, resting memory CD4 T cells, etc. Enrichment analysis showed that prognostic-related lncRNAs were involved in the cell cycle, p53 signaling pathway, non-alcoholic fatty liver disease, etc. A prognostic prediction signature, based on four-CNA-related lncRNAs, could contribute to a more accurate prognosis of patients with liver cancer.</p> <a href="javascript:ShowArticleAbstract(46);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords46" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(46);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh46" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(46);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant46" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(46);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors46" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zhenyun+Cheng%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zhenyun Cheng</a></li><ul><li>Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, No. 1 Jian She East Road, Zhengzhou, Henan, People's Republic of China, 450052.,Key Clinical Laboratory of Henan Province, NO.1 Jian She East Road, Zhengzhou, Henan, People's Republic of China, 450052<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yan+Guo%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yan Guo</a></li><ul><li>Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, No. 1 Jian She East Road, Zhengzhou, Henan, People's Republic of China, 450052.,Key Clinical Laboratory of Henan Province, NO.1 Jian She East Road, Zhengzhou, Henan, People's Republic of China, 450052<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Jingjing+Sun%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Jingjing Sun</a></li><ul><li>Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, No. 1 Jian She East Road, Zhengzhou, Henan, People's Republic of China, 450052.,Key Clinical Laboratory of Henan Province, NO.1 Jian She East Road, Zhengzhou, Henan, People's Republic of China, 450052<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lei+Zheng%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lei Zheng</a></li><ul><li>Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, No. 1 Jian She East Road, Zhengzhou, Henan, People's Republic of China, 450052. .,Key Clinical Laboratory of Henan Province, NO.1 Jian She East Road, Zhengzhou, Henan, People's Republic of China, 450052.<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(46);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow47"> <td style="min-width:40px;text-align:center;"> 47 </td> <td> <div id="citation47" class="article-citation"> <b>Zamani M</b>, Foroughmand AM, Hajjari MR, Bakhshinejad B, Johnson R, Galehdari H. CASC11 and PVT1 spliced transcripts play an oncogenic role in colorectal carcinogenesis. <em class='incite-journal-name' onclick='ShowInCiteJournal(9356);'>Front Oncol</em> 2022;<b>12</b>:954634. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36052265' target='_blank'>36052265</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424822' target='_blank'>PMC9424822</a> DOI: <a href='https://dx.doi.org/10.3389/fonc.2022.954634' target='_blank'>10.3389/fonc.2022.954634</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fonc.2022.954634','36052265', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(47);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fonc.2022.954634' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/106d7388222cc10eba882d4fcd486a7b/PMC9424822.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fonc.2022.954634');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9356);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/27/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/18/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/13/2022]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.3389/fonc.2022.954634" /> <div style="display:none" id="articleAbstract47" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <p>Cancer is fundamentally a genetic disorder that alters cellular information flow toward aberrant growth. The coding part accounts for less than 2% of the human genome, and it has become apparent that aberrations within the noncoding genome drive important cancer phenotypes. The numerous carcinogenesis-related genomic variations in the 8q24 region include single nucleotide variations (SNVs), copy number variations (CNVs), and viral integrations occur in the neighboring areas of the <italic>MYC</italic> locus. It seems that <italic>MYC</italic> is not the only target of these alterations. The <italic>MYC</italic>-proximal mutations may act <italic>via</italic> regulatory noncoding RNAs (ncRNAs). In this study, gene expression analyses indicated that the expression of some <italic>PVT1</italic> spliced linear transcripts, <italic>CircPVT1</italic>, <italic>CASC11</italic>, and <italic>MYC</italic> is increased in colorectal cancer (CRC). Moreover, the expression of these genes is associated with some clinicopathological characteristics of CRC. Also, <italic>in vitro</italic> studies in CRC cell lines demonstrated that <italic>CASC11</italic> is mostly detected in the nucleus, and different transcripts of <italic>PVT1</italic> have different preferences for nuclear and cytoplasmic parts. Furthermore, perturbation of <italic>PVT1</italic> expression and concomitant perturbation in <italic>PVT1</italic> and <italic>CASC11</italic> expression caused <italic>MYC</italic> overexpression. It seems that transcription of <italic>MYC</italic> is under regulatory control at the transcriptional level, i.e., initiation and elongation of transcription by its neighboring genes. Altogether, the current data provide evidence for the notion that these noncoding transcripts can significantly participate in the <italic>MYC</italic> regulation network and in the carcinogenesis of colorectal cells.</p> <a href="javascript:ShowArticleAbstract(47);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords47" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(47);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh47" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(47);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant47" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(47);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors47" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mina+Zamani%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mina Zamani</a></li><ul><li><institution>Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz</institution>, <addr-line>Ahvaz</addr-line>, <country>Iran</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ali-Mohammad+Foroughmand%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ali-Mohammad Foroughmand</a></li><ul><li><institution>Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz</institution>, <addr-line>Ahvaz</addr-line>, <country>Iran</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Mohammad-Reza+Hajjari%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Mohammad-Reza Hajjari</a></li><ul><li><institution>Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz</institution>, <addr-line>Ahvaz</addr-line>, <country>Iran</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Babak+Bakhshinejad%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Babak Bakhshinejad</a></li><ul><li><institution>Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University</institution>, <addr-line>Tehran</addr-line>, <country>Iran</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rory+Johnson%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rory Johnson</a></li><ul><li><institution>Department of Medical Oncology, Inselspital, Bern University Hospital, University of Bern</institution>, <addr-line>Bern</addr-line>, <country>Switzerland</country><li><li><institution>Department for BioMedical Research, University of Bern</institution>, <addr-line>Bern</addr-line>, <country>Switzerland</country><li><li><institution>School of Biology and Environmental Science, University College Dublin</institution>, <addr-line>Dublin</addr-line>, <country>Ireland</country><li><li><institution>Conway Institute for Biomolecular and Biomedical Research, University College Dublin</institution>, <addr-line>Dublin</addr-line>, <country>Ireland</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hamid+Galehdari%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hamid Galehdari</a></li><ul><li><institution>Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz</institution>, <addr-line>Ahvaz</addr-line>, <country>Iran</country><li><li>*Correspondence: Hamid Galehdari, <email xlink:href="mailto:" xmlns:xlink="http://www.w3.org/1999/xlink"></email><li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(47);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow48"> <td style="min-width:40px;text-align:center;"> 48 </td> <td> <div id="citation48" class="article-citation"> <b>Zhang H</b>, Liu X, Liu Y, Liu J, Gong X, Li G, Tang M. Crosstalk between regulatory non-coding RNAs and oxidative stress in Parkinson’s disease. <em class='incite-journal-name' onclick='ShowInCiteJournal(9330);'>Front Aging Neurosci</em> 2022;<b>14</b>:975248. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/36016854' target='_blank'>36016854</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9396353' target='_blank'>PMC9396353</a> DOI: <a href='https://dx.doi.org/10.3389/fnagi.2022.975248' target='_blank'>10.3389/fnagi.2022.975248</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fnagi.2022.975248','36016854', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(48);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(48);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fnagi.2022.975248' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/14658217b1683605e31aeb742dd723a8/PMC9396353.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fnagi.2022.975248');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9330);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 06/22/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 07/11/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/13/2022]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.3389/fnagi.2022.975248" /> <div style="display:none" id="articleAbstract48" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <jats:p>Parkinson’s disease is the second most common neurodegenerative disease after Alzheimer’s disease, which imposes an ever-increasing burden on society. Many studies have indicated that oxidative stress may play an important role in Parkinson’s disease through multiple processes related to dysfunction or loss of neurons. Besides, several subtypes of non-coding RNAs are found to be involved in this neurodegenerative disorder. However, the interplay between oxidative stress and regulatory non-coding RNAs in Parkinson’s disease remains to be clarified. In this article, we comprehensively survey and overview the role of regulatory ncRNAs in combination with oxidative stress in Parkinson’s disease. The interaction between them is also summarized. We aim to provide readers with a relatively novel insight into the pathogenesis of Parkinson’s disease, which would contribute to the development of pre-clinical diagnosis and treatment.</jats:p> <a href="javascript:ShowArticleAbstract(48);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords48" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(48);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh48" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(48);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant48" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22National+Natural+Science+Foundation+of+China%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">National Natural Science Foundation of China</a></li></ul> <a href="javascript:ShowArticleGrant(48);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors48" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Hantao+Zhang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Hantao Zhang</a></li><ul><li><institution>School of Life Sciences, Jiangsu University</institution>, <addr-line>Zhenjiang</addr-line>, <country>China</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xiaoyan+Liu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xiaoyan Liu</a></li><ul><li><institution>School of Life Sciences, Jiangsu University</institution>, <addr-line>Zhenjiang</addr-line>, <country>China</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yi+Liu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yi Liu</a></li><ul><li><institution>School of Life Sciences, Jiangsu University</institution>, <addr-line>Zhenjiang</addr-line>, <country>China</country><li><li><institution>Institute of Animal Husbandry, Jiangsu Academy of Agricultural Sciences</institution>, <addr-line>Nanjing</addr-line>, <country>China</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Junlin+Liu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Junlin Liu</a></li><ul><li><institution>School of Life Sciences, Jiangsu University</institution>, <addr-line>Zhenjiang</addr-line>, <country>China</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Xun+Gong%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Xun Gong</a></li><ul><li><institution>Department of Rheumatology & Immunology, Affiliated Hospital of Jiangsu University</institution>, <addr-line>Zhenjiang</addr-line>, <country>China</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gang+Li%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gang Li</a></li><ul><li><institution>Department of Vascular Surgery, The Second Affiliated Hospital of Shandong First Medical University</institution>, <addr-line>Taian</addr-line>, <country>China</country><li><li>*Correspondence: Gang Li <email></email> Min Tang <email></email><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Min+Tang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Min Tang</a></li><ul><li><institution>School of Life Sciences, Jiangsu University</institution>, <addr-line>Zhenjiang</addr-line>, <country>China</country><li><li>*Correspondence: Gang Li <email></email> Min Tang <email></email><li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(48);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow49"> <td style="min-width:40px;text-align:center;"> 49 </td> <td> <div id="citation49" class="article-citation"> <b>Jiang L</b>, Yang L, Dai Y, Yang G, Pan S. Expression of POT1-AS1 in GC Tissue, Its Effect on Biological Behavior of Gastric Cancer, and Its Significance on Prognosis of Gastric Cancer. <em>COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE</em> 2022;<b>2022</b>:6021994. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/35936358' target='_blank'>35936358</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355756' target='_blank'>PMC9355756</a> DOI: <a href='https://dx.doi.org/10.1155/2022/6021994' target='_blank'>10.1155/2022/6021994</a>]<span class="ref-count-nolink"> <span class="ref-count-sep">[</span>Citation(s) in <i>RCA</i>: 0<span class='ref-count-sep'>]</span></span><span class="ref-count-nolink"> <span class='ref-count-sep'>[</span>Impact Index Per Article: 0<span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.1155/2022/6021994','35936358', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(49);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleMeSH(49);" target='_self'>MESH Headings</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.1155/2022/6021994' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/1d8ad52b8424c1db548bb53f12c553e7/PMC9355756.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.1155/2022/6021994');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 05/24/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Revised: 06/20/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/24/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 11/30/2022]</span></span> </div> <input type="hidden" value="10.1155/2022/6021994" /> <div style="display:none" id="articleAbstract49" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <div class="abstract-label">Objective</div><div class="abstract-content">To study the correlation between gold in GC and biological indicators of gastric cancer (GC) and its effect on prognosis and correlation of POT1-AS1 with GC cellular growth, and to explore its impact in the processes of GC, to supply histological basis for medical treatment of GC. </div><div class="abstract-label">Methods</div><div class="abstract-content">From September 2019 to December 2021, 80 pairs of GAC specimens and healthy para-carcinoma tissue were immediately stored in paraformaldehyde solution. POT1-AS1 levels in 77 postoperative patients with GC were detected by immunohistochemical method. The correlation of the above indexes and the relationship between the above indexes and the biological behavior and prognosis of GC were analyzed. </div><div class="abstract-label">Results</div><div class="abstract-content">POT1-AS1 was strongly displayed in GAC specimens, and the difference between groups was statistically significant (P < 0.05). After sh-POT1-AS1 plasmid transfection, the relative expression of POT1-AS1 mRNA in SGC-7901 cells was remarkably lower compared to nontransfection group, and the difference between groups was statistically significant (P < 0.05). After POT1-AS1 knockdown, the SGC-7901 proliferation ability and the number of clones of SGC-7901 decreased remarkably. The relative level of cyclin D1 and cyclin-dependent kinase 4 (CDK4) in SGC-7901 reduced remarkably, while relative expression of cyclin-dependent kinase inhibitor 1A (CDKI1A) increased remarkably, and the difference between groups was statistically significant (P < 0.05). The positive expression of POT1-AS1 was found in GC and stromal cells. TIMP-1 in tumor stromal cells was related to the maximum diameter of tumor (P = 0.027), invasion depth (P = 0.001), lymph node metastasis (P = 0.006), and clinical stages (P = 0.006). TIMP-1 had an effect on the prognosis, while the strong positive group had a poor prognosis. The expression of TIMP-1 in GC cells was not related to clinical biological behavior and prognosis of GC. The VEGF level in GC was correlated to tumor maximum diameter (P < 0.05), invasive depth (P < 0.05), and lymph node metastasis (P < 0.05) that was linked to clinical phases, and the difference between groups was statistically significant (P < 0.05), which was positively correlated with Ki67-LI; the correlation coefficient was 0.254 and P = 0.026, which was not related to the positive expression of TIMP-1 in GC cells and stromal cells. VECF has an effect on the prognosis, and the outcomes of the positive group are worse. </div><div class="abstract-label">Conclusion</div><div class="abstract-content">The correlation between TIMP-1 of GASTRIC cancer mesenchymal cells of POT1-AS1 and VEGF and Ki-67-Li suggests that TIMP-1 produced by mesenchymal cells can facilitate tumor progression and lead to poor prognosis by promoting tumor cell proliferation. VEGF can strengthen tumor angiogenesis and then promote tumor cell proliferation, which has an adverse effect on the prognosis. Ki-67-LI is correlated to the medical biological behavior and prognosis of the tumor, reflecting the malignant process of the tumor. </div> <a href="javascript:ShowArticleAbstract(49);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords49" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(49);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh49" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Line%2c+Tumor%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Line, Tumor</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Cell+Proliferation%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Cell Proliferation/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Gene+Expression+Regulation%2c+Neoplastic%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Gene Expression Regulation, Neoplastic</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Humans%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Humans</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ki-67+Antigen%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ki-67 Antigen/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ki-67+Antigen%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ki-67 Antigen/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lymphatic+Metastasis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lymphatic Metastasis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Prognosis%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Prognosis</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22RNA%2c+Long+Noncoding%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">RNA, Long Noncoding/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Shelterin+Complex%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Shelterin Complex</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Stomach+Neoplasms%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Stomach Neoplasms/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Telomere-Binding+Proteins%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Telomere-Binding Proteins/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Telomere-Binding+Proteins%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Telomere-Binding Proteins/metabolism</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Tissue+Inhibitor+of+Metalloproteinase-1%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Tissue Inhibitor of Metalloproteinase-1/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vascular+Endothelial+Growth+Factor+A%2fgenetics%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vascular Endothelial Growth Factor A/genetics</a></li><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22mesh%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Vascular+Endothelial+Growth+Factor+A%2fmetabolism%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Vascular Endothelial Growth Factor A/metabolism</a></li></ul> <a href="javascript:ShowArticleMeSH(49);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant49" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <a href="javascript:ShowArticleGrant(49);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors49" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Li+Jiang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Li Jiang</a></li><ul><li>Department of Pathology, Liyang People's Hospital, 213300, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Lie+Yang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Lie Yang</a></li><ul><li>Department of Pathology, Liyang People's Hospital, 213300, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yun+Dai%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yun Dai</a></li><ul><li>Department of Pathology, Liyang People's Hospital, 213300, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Guangming+Yang%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Guangming Yang</a></li><ul><li>Department of Pathology, Liyang People's Hospital, 213300, China<li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Shuyin+Pan%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Shuyin Pan</a></li><ul><li>Department of Pathology, Liyang People's Hospital, 213300, China<li></ul></td><td></td></tr></table> <a href="javascript:ShowArticleAuthors(49);" target="_self" style="float:right;">Collapse</a> </div> </td> </tr> <tr id="articlerow50"> <td style="min-width:40px;text-align:center;"> 50 </td> <td> <div id="citation50" class="article-citation"> <b>Sun C</b>, Chen Y, Kim NH, Lowe S, Ma S, Zhou Z, Bentley R, Chen YS, Tuason MW, Gu W, Bhan C, Tuason JPW, Thapa P, Cheng C, Zhou Q, Zhu Y. Identification and Verification of Potential Biomarkers in Gastric Cancer By Integrated Bioinformatic Analysis. <em class='incite-journal-name' onclick='ShowInCiteJournal(9542);'>Front Genet</em> 2022;<b>13</b>:911740. [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/35910202' target='_blank'>35910202</a> PMCID: <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9337873' target='_blank'>PMC9337873</a> DOI: <a href='https://dx.doi.org/10.3389/fgene.2022.911740' target='_blank'>10.3389/fgene.2022.911740</a>]<span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://www.referencecitationanalysis.com/citearticles?term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22c%22%2c%22o%22%3anull%2c%22v%22%3a%2210.3389%2ffgene.2022.911740%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d' target='_blank'>Citation(s) in <i>RCA</i>: 1</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInflu('10.3389%2ffgene.2022.911740')">Impact Index Per Article: 0.5</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="sra" onclick="ShowRefArticle('10.3389/fgene.2022.911740','35910202', '00004112')">Reference Citation Analysis</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleAbstract(50);" name="saa" target='_self'>Abstract</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowArticleGrant(50);" target='_self'>Grants</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='http://dx.doi.org/10.3389/fgene.2022.911740' target='_blank'>Track Full Text</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://rcastoragev2.blob.core.windows.net/4536b274d05f2960d15ef616c9e07b5f/PMC9337873.pdf' target='_blank'>Download PDF</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' name="openf" onclick="OpenFigures('10.3389/fgene.2022.911740');">Figures</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' onclick="ShowInCiteJournal(9542);" name="showj" target='_self'>Journal Information</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/subscribe' target="_blank">Subscribe</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[</span><a href='https://referencecitationanalysis.com/ScholarRegist' target="_blank">Scholar Register</a><span class='ref-count-sep'>]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Received: 04/12/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Accepted: 06/08/2022]</span></span><span class="ref-count"> <span class='ref-count-sep'>[Indexed: 12/13/2022]</span></span><span class="ref-count">  Open</span> </div> <input type="hidden" value="10.3389/fgene.2022.911740" /> <div style="display:none" id="articleAbstract50" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Abstract</b> <p><bold>Background:</bold> Gastric cancer (GC) is a common cancer with high mortality. This study aimed to identify its differentially expressed genes (DEGs) using bioinformatics methods.</p><p><bold>Methods:</bold> DEGs were screened from four GEO (Gene Expression Omnibus) gene expression profiles. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed. A protein–protein interaction (PPI) network was constructed. Expression and prognosis were assessed. Meta-analysis was conducted to further validate prognosis. The receiver operating characteristic curve (ROC) was analyzed to identify diagnostic markers, and a nomogram was developed. Exploration of drugs and immune cell infiltration analysis were conducted.</p><p><bold>Results:</bold> Nine up-regulated and three down-regulated hub genes were identified, with close relations to gastric functions, extracellular activities, and structures. Overexpressed Collagen Type VIII Alpha 1 Chain (COL8A1), Collagen Type X Alpha 1 Chain (COL10A1), Collagen Triple Helix Repeat Containing 1 (CTHRC1), and Fibroblast Activation Protein (FAP) correlated with poor prognosis. The area under the curve (AUC) of ADAM Metallopeptidase With Thrombospondin Type 1 Motif 2 (ADAMTS2), COL10A1, Collagen Type XI Alpha 1 Chain (COL11A1), and CTHRC1 was >0.9. A nomogram model based on CTHRC1 was developed. Infiltration of macrophages, neutrophils, and dendritic cells positively correlated with COL8A1, COL10A1, CTHRC1, and FAP. Meta-analysis confirmed poor prognosis of overexpressed CTHRC1.</p><p><bold>Conclusion:</bold> ADAMTS2, COL10A1, COL11A1, and CTHRC1 have diagnostic values in GC. COL8A1, COL10A1, CTHRC1, and FAP correlated with worse prognosis, showing prognostic and therapeutic values. The immune cell infiltration needs further investigations.</p> <a href="javascript:ShowArticleAbstract(50);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleKeywords50" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Key Words</b> <a href="javascript:ShowArticleKeywords(50);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleMesh50" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">MESH Headings</b> <a href="javascript:ShowArticleMeSH(50);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleGrant50" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Grants</b> <ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22fund%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Anhui+Medical+University%5cn%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Anhui Medical University </a></li></ul> <a href="javascript:ShowArticleGrant(50);" target="_self" style="float:right;">Collapse</a> </div> <div style="display:none" id="articleAuthors50" class="article-abstract"> <b style="display:block;padding-bottom:0.5rem;font-size:1rem;">Affiliation(s)</b> <table class="authors-inlist-container"><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chenyu+Sun%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chenyu Sun</a></li><ul><li><institution>AMITA Health Saint Joseph Hospital Chicago</institution>, <addr-line>Chicago</addr-line>, <addr-line>IL</addr-line>, <country>United States</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yue+Chen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yue Chen</a></li><ul><li><institution>Department of Clinical Medicine</institution>, <institution>School of the First Clinical Medicine</institution>, <institution>Anhui Medical University</institution>, <addr-line>Hefei</addr-line>, <country>China</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Na+Hyun+Kim%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Na Hyun Kim</a></li><ul><li><institution>AMITA Health Saint Joseph Hospital Chicago</institution>, <addr-line>Chicago</addr-line>, <addr-line>IL</addr-line>, <country>United States</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Scott+Lowe%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Scott Lowe</a></li><ul><li><institution>College of Osteopathic Medicine</institution>, <institution>Kansas City University</institution>, <addr-line>Kansas City</addr-line>, <addr-line>MO</addr-line>, <country>United States</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Shaodi+Ma%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Shaodi Ma</a></li><ul><li><institution>Department of Epidemiology and Health Statistics</institution>, <institution>School of Public Health</institution>, <institution>Anhui Medical University</institution>, <addr-line>Hefei</addr-line>, <country>China</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Zhen+Zhou%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Zhen Zhou</a></li><ul><li><institution>Menzies Institute for Medical Research</institution>, <institution>University of Tasmania</institution>, <addr-line>Hobart</addr-line>, <addr-line>TAS</addr-line>, <country>Australia</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Rachel+Bentley%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Rachel Bentley</a></li><ul><li><institution>College of Osteopathic Medicine</institution>, <institution>Kansas City University</institution>, <addr-line>Kansas City</addr-line>, <addr-line>MO</addr-line>, <country>United States</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Yi-Sheng+Chen%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Yi-Sheng Chen</a></li><ul><li><institution>Department of Orthopedics</institution>, <institution>Shanghai General Hospital</institution>, <institution>Shanghai Jiao Tong University School of Medicine</institution>, <institution>Shanghai Jiao Tong University</institution>, <addr-line>Shanghai</addr-line>, <country>China</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Margarita+Whitaker+Tuason%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Margarita Whitaker Tuason</a></li><ul><li><institution>Faculty of Medicine and Surgery</institution>, <institution>University of Santo Thomas</institution>, <addr-line>Metro Manila</addr-line>, <country>Philippines</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Wenchao+Gu%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Wenchao Gu</a></li><ul><li><institution>Department of Diagnostic Radiology and Nuclear Medicine</institution>, <institution>Gunma University Graduate School of Medicine</institution>, <addr-line>Maebashi</addr-line>, <country>Japan</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Chandur+Bhan%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Chandur Bhan</a></li><ul><li><institution>AMITA Health Saint Joseph Hospital Chicago</institution>, <addr-line>Chicago</addr-line>, <addr-line>IL</addr-line>, <country>United States</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22John+Pocholo+Whitaker+Tuason%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">John Pocholo Whitaker Tuason</a></li><ul><li><institution>AMITA Health Saint Joseph Hospital Chicago</institution>, <addr-line>Chicago</addr-line>, <addr-line>IL</addr-line>, <country>United States</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Pratikshya+Thapa%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Pratikshya Thapa</a></li><ul><li><institution>AMITA Health Saint Joseph Hospital Chicago</institution>, <addr-line>Chicago</addr-line>, <addr-line>IL</addr-line>, <country>United States</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Ce+Cheng%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Ce Cheng</a></li><ul><li><institution>The University of Arizona College of Medicine</institution>, <addr-line>Tucson</addr-line>, <addr-line>AZ</addr-line>, <country>United States</country><li><li><institution>Banner-University Medical Center South</institution>, <addr-line>Tucson</addr-line>, <addr-line>AZ</addr-line>, <country>United States</country><li></ul></td><td></td></tr><tr><td><ul><li><a href="/search?page=1&sort=&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22an%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%22Qin+Zhou%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" target="_blank">Qin Zhou</a></li><ul><li><institution>Mayo Clinic</institution>, <addr-line>Rochester</addr-line>, <addr-line>MN</addr-line>, <country>United States</country><li></ul></td><td></td></tr><tr><td><ul><li><a 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class="dxp-num dxp-current page-number" style="margin-left:0px;">1</b><a class="dxp-num page-number" href="/citearticles?page=2&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22cr%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%2200004112%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">2</a><a class="dxp-num page-number" href="/citearticles?page=3&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22cr%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%2200004112%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">3</a><a class="dxp-num page-number" href="/citearticles?page=4&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22cr%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%2200004112%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;">4</a><a class="dxp-button dxp-bi" onclick="ASPx.PGNav(event);" href="/citearticles?page=2&sort=pdate&term=%5b%7b%22c%22%3anull%2c%22id%22%3a%22cr%22%2c%22o%22%3a%22eq%22%2c%22v%22%3a%2200004112%22%2c%22b%22%3anull%2c%22f%22%3anull%7d%5d" style="margin-left:0px;"><img class="dxWeb_pNext_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Next" /></a> </div><b class="dx-clear"></b><script id="dxss_560651960" type="text/javascript">  </script> </div> </div> <div class="cl"></div> </div> </div> </div> <div id="RootHolder_articleCitationPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:450px;width:600px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content">    </div> </div> </div> </div><div id="RootHolder_articleCitationPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleCitationPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleCitationPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleCitationPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_1115091042" type="text/javascript">  </script> <div id="RootHolder_chartPopupControl_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:1000px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_chartPopupControl_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam"></span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content" style="overflow-x:hidden;overflow-y:scroll;">    </div> </div> </div> </div><div id="RootHolder_chartPopupControl_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_chartPopupControl_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_chartPopupControl_TL">Loading…</span></td> </tr> </table><div id="RootHolder_chartPopupControl_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_420552910" type="text/javascript">  </script> <div id="RootHolder_articleExportPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:400px;width:500px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow" style="font-size:11pt;"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-maximizeBtn"> <img id="RootHolder_articleExportPopup_HMXB-1Img" class="dxWeb_pcMaximizeButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Maximize/Restore" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Export Articles to File</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="dxtcLite_MetropolisBlue dxtcSys dxtc-init dxtc-top dxtc-pc" id="RootHolder_articleExportPopup_ExportFilePageControl" style="width:100%;"> <ul class="dxtc-strip dxtc-row dxtc-stripContainer"> <li class="dxtc-leftIndent"> </li><li class="dxtc-tab dxtc-lead dxtc-last" style="display:none;"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-activeTab dxtc-lead dxtc-last"><a class="dxtc-link"><span class="dx-vam">Export Citation Analysis</span></a></li><li class="dxtc-rightIndent"> </li> </ul><div class="dxtc-content"> <div> <div> <div class="dxflFormLayout_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout" style="font-size:11pt;width:100%;"> <table class="dxflGroup_MetropolisBlue dxflGroupSys dxflAGSys" style="border-collapse:separate;"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_0" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="padding-bottom:10px;"> <table> <tr> <td> <span style="font-weight:bold">Article Number From</span> </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportStartIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportStartIndex')" value="1" type="text" /></td> </tr> </table><script id="dxss_814491935" type="text/javascript">  </script> </td> <td> to    </td> <td> <table class="dxeTextBoxSys dxeTextBox_MetropolisBlue dxeTextBoxDefaultWidthSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex" style="width:80px;"> <tr> <td class="dxic" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$ExportEndSIndex" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" onchange="ASPx.EValueChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportEndSIndex')" value="151" type="text" /></td> </tr> </table><script id="dxss_1331245653" type="text/javascript">  </script> </td> </tr> <tr> <td colspan="4" style="padding-left:20px;padding-top:5px;"> A maximum of 600 records can be exported at a time. </td> </tr> </table> </div></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_1" class="dxflGroupCell_MetropolisBlue"><table class="dxflCLLSys dxflItemSys dxflTextEditItemSys dxflItem_MetropolisBlue" style="border-collapse:separate;padding-bottom:20px;"> <tr> <td class="dxflHALSys dxflVATSys dxflCaptionCell_MetropolisBlue dxflCaptionCellSys"><label class="dxflCaption_MetropolisBlue" for="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" style="font-weight:bold;">Format:</label><em class="dxflRequired_MetropolisBlue">*</em></td><td class="dxflNestedControlCell_MetropolisBlue"> <table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_ET" class="dxeValidDynEditorTable dxeRoot_MetropolisBlue"> <tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_CC"><table class="dxeButtonEditSys dxeButtonEdit_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat" style="width:200px;border-collapse:separate;"> <tr> <td style="display:none;"><input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" name="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_VI" type="hidden" value="1" /></td><td class="dxic" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="width:100%;"><input class="dxeEditArea_MetropolisBlue dxeEditAreaSys" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_I" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat" onfocus="ASPx.EGotFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onblur="ASPx.ELostFocus('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" onchange="ASPx.ETextChanged('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat')" value="Excel" type="text" /></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1" class="dxeButton dxeButtonEditButton_MetropolisBlue" onmousedown="return ASPx.DDDropDown('RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat', event)" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"><img id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_B-1Img" class="dxEditors_edtDropDown_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="v" /></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_PW-1" class="dxpcDropDown_MetropolisBlue dxpclW dxpc-ddSys" style="z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper"> <div class="dxpc-content"> <table class="dxeListBox_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L" style="border-collapse:separate;"> <tr> <td style="vertical-align:Top;"><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_D" class="dxlbd" style="width:100%;overflow-x:hidden;overflow-y:auto;"> <input id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_VI" type="hidden" name="ctl00$RootHolder$articleExportPopup$ExportFilePageControl$ExportPopupFormLayout$FileFormat$DDD$L" /><table style="border-collapse:separate;visibility:hidden!important;display:none!important;"> <tr id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBI-1" class="dxeListBoxItemRow_MetropolisBlue"> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBII" class="dxeListBoxItem_MetropolisBlue"> </td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_DDD_L_LBT" style="width:100%;border-collapse:separate;"> <tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Excel</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">Plain Text</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">PDF</td> </tr><tr class="dxeListBoxItemRow_MetropolisBlue"> <td class="dxeListBoxItem_MetropolisBlue">WORD</td> </tr> </table> </div></td> </tr> </table><script id="dxss_1509722775" type="text/javascript">  </script> </div> </div> </div> </div><script id="dxss_960798088" type="text/javascript">  </script></td><td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_EC" class="dxeErrorCell_MetropolisBlue dxeErrorFrame_MetropolisBlue dxeErrorFrameSys dxeErrorCellSys dxeNoBorderLeft" style="vertical-align:middle;display:none;white-space:nowrap;">Invalid value</td> </tr> </table><table id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LP" class="dxeLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_FileFormat_LD" class="dxeLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_835950349" type="text/javascript">  </script> </td> </tr> </table></td> </tr><tr> <td id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_2" class="dxflGroupCell_MetropolisBlue"><div class="dxflNestedControlCell_MetropolisBlue dxflCLLSys dxflItemSys dxflTextItemSys dxflItem_MetropolisBlue"> <a class="dxeHyperlink_MetropolisBlue" id="RootHolder_articleExportPopup_ExportFilePageControl_ExportPopupFormLayout_ExportedFileLink" target="_blank" rel="noopener noreferrer">Click to Download the Exported File</a><script id="dxss_308093146" type="text/javascript">  </script> </div></td> </tr> </table> </div><script id="dxss_2113481676" type="text/javascript">  </script> </div> </div> </div> </div><b class="dx-clear"></b><table id="RootHolder_articleExportPopup_ExportFilePageControl_LP" class="dxtcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="RootHolder_articleExportPopup_ExportFilePageControl_TL">Loading…</span></td> </tr> </table><script id="dxss_164845594" type="text/javascript">  </script> </div> </div><div class="dxpc-footer"> <div class="popup-footer-button-container"> <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnExportArticles_I" class="dxb-hb" value="Export" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnExportArticles" /><span class="dx-vam">Export</span> </div> </div><script id="dxss_77486387" type="text/javascript">  </script>    <div class="dxbButton_MetropolisBlue DefaultButton dxbButtonSys dxbTSys" id="RootHolder_articleExportPopup_TPCFm1_btnCancel" style="user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxb"> <input id="RootHolder_articleExportPopup_TPCFm1_btnCancel_I" class="dxb-hb" value="Cancel" type="submit" name="ctl00$RootHolder$articleExportPopup$TPCFm1$TC$btnCancel" /><span class="dx-vam">Cancel</span> </div> </div><script id="dxss_2118985763" type="text/javascript">  </script> </div> </div> </div> </div><div id="RootHolder_articleExportPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="RootHolder_articleExportPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="font-size:11pt;left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="font-size:11pt;padding-left:0px;"><span id="RootHolder_articleExportPopup_TL">Loading…</span></td> </tr> </table><div id="RootHolder_articleExportPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_797146157" type="text/javascript">  </script> </div> <div class="bottom-part cl"> © 2004-2024 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <div class="scroll"> <a href="#top" target="_self"> <img src="/Contents/Images/backtop3.png" /> </a> </div> <div id="categorySelectorPopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:800px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header drag dxpc-withBtn" style="font-size:20px;user-select:none;-khtml-user-select:none;-ms-user-select:none;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Select the Category</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="categorySelectorPopup_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="categorySelectorPopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="categorySelectorPopup_TL">Loading…</span></td> </tr> </table><div id="categorySelectorPopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_166253781" type="text/javascript">  </script> <div id="pcLoginPopUp_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:500px;width:700px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-contentWrapper" style="overflow:auto;"> <div class="dxpc-content"> </div> </div> </div> </div><div id="pcLoginPopUp_DXPWMB-1" class="dxpcModalBackLite_MetropolisBlue" style="z-index:9999;"> </div><table id="pcLoginPopUp_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="pcLoginPopUp_TL">Loading…</span></td> </tr> </table><div id="pcLoginPopUp_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_430910140" type="text/javascript">  </script> <div id="aiComputePopup_PW-1" class="dxpcLite_MetropolisBlue dxpclW" style="height:200px;width:300px;z-index:10000;display:none;visibility:hidden;"> <div class="dxpc-mainDiv dxpc-shadow"> <div class="dxpc-header dxpc-withBtn" style="font-size:20px;"> <div class="dxpc-closeBtn"> <img class="dxWeb_pcCloseButton_MetropolisBlue" src="/DXR.axd?r=1_58-HCSds" alt="Close" /> </div><div class="dxpc-headerContent"> <span class="dxpc-headerText dx-vam">Impact Index Per Article</span> </div><b class="dx-clear"></b> </div><div class="dxpc-contentWrapper"> <div class="dxpc-content"> <div class="ai-content-container"> <p> <b>Calculation for Impact Index Per Article</b> </p> <p> Times Cited ÷ Number of Years = Impact Index Per Article<sup class="standard-yellow">TM</sup> </p> </div> </div> </div> </div> </div><table id="aiComputePopup_LP" class="dxpcLoadingPanel_MetropolisBlue dxlpLoadingPanel_MetropolisBlue" style="left:0px;top:0px;z-index:30000;display:none;"> <tr> <td class="dx" style="padding-right:0px;"><img class="dxlp-loadingImage dxlp-imgPosLeft" src="/DXR.axd?r=1_58-HCSds" alt="" style="vertical-align:middle;" /></td><td class="dx" style="padding-left:0px;"><span id="aiComputePopup_TL">Loading…</span></td> </tr> </table><div id="aiComputePopup_LD" class="dxpcLoadingDiv_MetropolisBlue dxlpLoadingDiv_MetropolisBlue dx-ft" style="left:0px;top:0px;z-index:29999;display:none;position:absolute;"> </div><script id="dxss_698179129" type="text/javascript">  </script> <script type="text/javascript"> //<![CDATA[ var callBackFrameUrl='/WebResource.axd?d=beToSAE3vdsL1QUQUxjWdX-3aFLejnBliGvqSCZYULGFdxZmRlcJcqs71AKVNTQEXljNmd0slFkUZ_AFaCke4Q2&t=638628207619783110'; WebForm_InitCallback();//]]> </script> </form> </body> </html>