Lynne E. Maquat, Ph.D.

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Maquat, Ph.D.</span> </div> </div> <div class="mt-8 md:mt-10 lg:mt-16 md:flex md:gap-x-5 xl:gap-x-0"> <div class="w-1/3 min-w-[7.5rem] max-w-[18.75rem] xl:mr-32"> <div class="aspect-w-12 aspect-h-16 rounded overflow-hidden mb-7 bg-slate-300"> <img class="object-cover" src="https://www.urmc.rochester.edu/ecv_binary/faculty/generated/profile_web/5781.jpg" alt="Lynne E. Maquat, Ph.D." title="Lynne E. Maquat, Ph.D." loading="lazy" /> </div> </div> <div class="w-full"> <div class="space-y-2 border-b-2 border-bg-stone-200 pb-5"> <div class="inline-flex flex-wrap items-center gap-x-4"> <h1>Lynne E. Maquat, Ph.D.</h1> </div> </div> <div class="pt-6 gap-16 lg:grid lg:grid-cols-2"> <div class="w-full"> <div> <h2 class="mb-2">Contact</h2> <div class="divide-y-2 divide-bg-stone-200"> <div class="flex justify-between py-2 font-bold text-body-regular"> <span>Office</span> <a class="text-pacific-blue hover:underline hover:text-navy-blue" href="tel:5852735640"> (585) 273-5640 </a> </div> <div class="flex justify-between py-2 font-bold text-body-regular"> <span>Fax</span> <a class="text-pacific-blue hover:underline hover:text-navy-blue" href="tel:5852712683"> (585) 271-2683 </a> </div> </div> </div> <div class="mt-10"> <h3 class="mb-6">Connect with Lynne E. Maquat, Ph.D.</h3> <div class="space-y-4"> <p> <span class="inline-block"> <a class="prepend-icon btn-link font-normal decoration-from-font" href="https://twitter.com/MaquatLab"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512" fill="currentColor" class="w-5 h-5"> <path d="M389.2 48h70.6L305.6 224.2 487 464H345L233.7 318.6 106.5 464H35.8L200.7 275.5 26.8 48H172.4L272.9 180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z" /> </svg> <span>@MaquatLab</span> </a> </span> </p> <p> <span class="inline-block text-pacific-blue"> <a class="btn-link font-normal decoration-from-font append-icon" href="https://www.urmc.rochester.edu/rna-biology.aspx"><span> Center for RNA Biology</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> </span> </p> <p> <span class="inline-block text-pacific-blue"> <a class="btn-link font-normal decoration-from-font append-icon" href="mailto:Elizabeth_Raymonda@URMC.Rochester.edu"><span>Personal Assistant Contact</span><svg class="w-4 h-4 fill-current" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"> <path d="M264.6 70.63l176 168c4.75 4.531 7.438 10.81 7.438 17.38s-2.688 12.84-7.438 17.38l-176 168c-9.594 9.125-24.78 8.781-33.94-.8125c-9.156-9.5-8.812-24.75 .8125-33.94l132.7-126.6H24.01c-13.25 0-24.01-10.76-24.01-24.01s10.76-23.99 24.01-23.99h340.1l-132.7-126.6C221.8 96.23 221.5 80.98 230.6 71.45C239.8 61.85 254.1 61.51 264.6 70.63z" /> </svg></a> </span> </p> </div> </div> </div> <div> <div class="mt-6 drop-shadow-dim bg-white border border-stone-200 p-7 lg:mt-0"> <h3>Looking for more Information?</h3> <p class="mb-6"> Visit my lab website to learn more about my research, collaborators, latest news, etc. </p> <div class="space-y-4"> <a class="btn btn-primary" href="http://www.urmc.rochester.edu/labs/Maquat-Lab/">Visit Research Lab Website</a> </div> </div> </div> </div> </div> </div> </section> </div> <div class="max-w-screen-xl mx-auto py-12 px-5 w-full scroll-mt-24 sm:px-10 md:py-16 xl:flex xl:justify-between" x-data="{ locationsActive: false, insuranceActive: false, aboutActive: false, credentialsActive: false, researchActive: false, publicationsActive: false, ratingsActive: false }"> <div class="hidden text-lg sticky top-36 self-start xl:block w-1/3"> <p class="text-xl font-bold mb-4">Lynne E. Maquat, Ph.D.</p> <ul class="space-y-8 border-l-[3px] border-pearl-gray list-none pl-0"> <li> <a class="pl-3.5 py-0.5 border-l-[3px] -ml-[3px] text-navy-blue hover:underline" :class="{ 'border-pacific-blue text-pacific-blue font-bold': aboutActive }" href="#about"> About Me </a> </li> <li> <a class="pl-3.5 py-0.5 border-l-[3px] -ml-[3px] text-navy-blue hover:underline" :class="{ 'border-pacific-blue text-pacific-blue font-bold': credentialsActive }" href="#credentials">Credentials</a> </li> <li> <a class="pl-3.5 py-0.5 border-l-[3px] -ml-[3px] text-navy-blue hover:underline" :class="{ 'border-pacific-blue text-pacific-blue font-bold': researchActive }" href="#research">Research</a> </li> <li> <a class="pl-3.5 py-0.5 border-l-[3px] -ml-[3px] text-navy-blue hover:underline" :class="{ 'border-pacific-blue text-pacific-blue font-bold': publicationsActive }" href="#publications">Publications</a> </li> </ul> </div> <div class="flex-1 space-y-12 text-med-gray md:space-y-16"> <section class="scroll-mt-36" id="about" x-intersect:enter.margin.-50%="locationsActive = false, insuranceActive = false, aboutActive = true, credentialsActive = false, researchActive = false, publicationsActive = false, ratingsActive = false"> <h2 class="mb-6">About Me</h2> <div class="space-y-8"> <div x-data="{ aboutMeBioExpanded: false }"> <div class="relative"> <div x-show="!aboutMeBioExpanded"> <div>Lynne E. Maquat, PhD is the J. Lowell Orbison Endowed Chair and Professor of Biochemistry & Biophysics who holds concomitant appointments in Pediatrics and in Oncology, Founding Director of the Center for RNA Biology, and Founding Chair of Graduate Women in Science at the University of Rochester, Ro...</div> </div> <div x-cloak x-show="aboutMeBioExpanded"> <div>Lynne E. Maquat, PhD is the J. Lowell Orbison Endowed Chair and Professor of Biochemistry & Biophysics who holds concomitant appointments in Pediatrics and in Oncology, Founding Director of the Center for RNA Biology, and Founding Chair of Graduate Women in Science at the University of Rochester, Rochester, NY. After obtaining her PhD in Biochemistry from the University of Wisconsin-Madison and undertaking post-doctoral work at the McArdle Laboratory for Cancer Research, she joined Roswell Park Cancer Institute before moving to the University of Rochester Medical Center. Dr. Maquat’s research focuses on the molecular basis of human diseases, with particular interest in mechanisms of mRNA decay. Maquat discovered nonsense-mediated mRNA decay (NMD) in human diseases in 1981 and, subsequently, the exon-junction complex (EJC) and how the EJC marks mRNAs for a quality-control “pioneer” round of protein synthesis. She also discovered Staufen-mediated mRNA decay, which mechanistically competes with NMD and, by so doing, new roles for short interspersed elements and long non-coding RNAs. Additionally, she has defined a new mechanism by which microRNAs are degraded, thereby regulating mRNAs so as to promote the cell cycle. One of her current interests focuses on the development of therapeutics for diseases that she has shown manifest hyperactivated NMD, including the most common single gene cause of intellectual disability and autism, Fragile X Syndrome. Maquat is an elected Fellow of the American Association for the Advancement of Science (2006); an elected Member of the American Academy of Arts & Sciences (2006), the National Academy of Sciences (2011), and the National Academy of Medicine (2017); and a Batsheva de Rothschild Fellow of the Israel Academy of Sciences & Humanities (2012-3). She was recently elected to the Council of Scientific Advisors for the International Centre for Genetic Engineering and Biotechnology (ICGEB), an initiate of the United Nations Industrial Development Organization (2022). She received the William C. Rose Award from the American Society for Biochemistry & Molecular Biology (2014), a Canada Gairdner International Award (2015), the international RNA Society Lifetime Achievement Award in Service (2010) and in Science (2017), the FASEB Excellence in Science Award (2018), the Vanderbilt Prize in Biomedical Science (2017), the Wiley Prize in Biomedical Sciences from Rockefeller University (2018), the International Union of Biochemistry and Molecular Biology Medal (2019), the Wolf Prize in Medicine from Isreal (2021), the Warren Alpert Foundation Prize from Harvard Medical School (2021), and the Gruber Genetics Prize from the Gruber Foundation and Yale University (2023). Most recently, she has been awarded the Dr. Paul Janssen Prize in Biomedical Research from Johnson & Johnson (2024), and the Albany Prize in Medicine and Biomedical Research from Albany Medical Center (2024). Maquat is also well-known for her national and international efforts to promote women in science.</div> </div> </div> <button @click="aboutMeBioExpanded = ! aboutMeBioExpanded" class="text-pacific-blue hover:underline flex items-center font-semibold mt-3"> <svg xmlns="http://www.w3.org/2000/svg" class="h-5 w-5 mr-3.5 transition-all" :class="{ 'rotate-180': aboutMeBioExpanded }" fill="none" viewBox="0 0 24 24" stroke="currentColor" stroke-width="2"> <path stroke-linecap="round" stroke-linejoin="round" d="M19 9l-7 7-7-7" /> </svg> <span>Read <span x-show="!aboutMeBioExpanded">More</span><span x-cloak x-show="aboutMeBioExpanded">Less</span></span> </button> </div> <div> <h3 class="mb-2 mt-6">Faculty Appointments</h3> <div class="space-y-2"> <p> <span> <span class="font-bold"> Professor </span> - Department of Biochemistry and Biophysics (SMD) </span> </p> <p> <span> <span class="font-bold"> Director, Center for RNA Biology </span> - Office of VP for Health Sciences (URMC) </span> </p> <p> <span> <span class="font-bold"> J. Lowell Orbison Distinguished Service Alumni Professorship </span> - Dean's Office, SMD (SMD) </span> </p> </div> </div> </div> </section> <section id="credentials" class="scroll-mt-36" x-intersect:enter.margin.-50%="locationsActive = false, insuranceActive = false, aboutActive = false, credentialsActive = true, researchActive = false, publicationsActive = false, ratingsActive = false"> <h2 class="mb-6">Credentials</h2> <div class="space-y-8"> <div> <h3 class="mb-2">Education</h3> <div class="space-y-2"> <p> <span>PhD | Univ Wisconsin-Madison.</span> <span>Biochemistry.</span> <span>1979</span> </p> <p> <span>BA | University of Connecticut.</span> <span>Biology.</span> <span>1974</span> </p> </div> </div> <div> <h3 class="mb-2">Awards</h3> <div class="space-y-2" x-data="{ awardsExpanded: false }"> <p> <span>Dr. Paul Janssen Award.</span> <span>2024</span> </p> <p> <span>Albany Medical Center Prize in Medicine and Biomedical Research.</span> <span>2024</span> </p> <p> <span>Gruber Genetics Prize.</span> <span>2023</span> </p> <div class="relative"> <div x-show="awardsExpanded" x-collapse.min.28px> <div class="absolute inset-x-0 bottom-0 bg-gradient-to-b from-transparent to-white ease-in duration-150 z-10" :class="{ 'h-0': awardsExpanded, 'h-14': !awardsExpanded }"></div> <div class="space-y-2"> <p> <span>Wolf Prize in Medicine.</span> <span>2021</span> </p> <p> <span>Warren Alpert Prize.</span> <span>2021</span> </p> <p> <span>Warren Alpert Foundation Prize.</span> <span>2021</span> </p> <p> <span>IUBMB Jubilee Award.</span> <span>2019</span> </p> <p> <span>FASEB Excellence in Science Award.</span> <span>2018</span> </p> <p> <span>Wiley Prize in Biomedical Sciences.</span> <span>2018</span> </p> <p> <span>2017 International RNA Society Lifetime Achievement in Science Award.</span> <span>2017</span> </p> <p> <span>2017 Vanderbilt Prize in Biomedical Science.</span> <span>2017</span> </p> <p> <span>Elected to the National Academy of Medicine.</span> <span>2017</span> </p> <p> <span>Canada Gairdner International Award.</span> <span>2015</span> </p> <p> <span>William C. Rose Award.</span> <span>2014</span> </p> <p> <span>Athena Award.</span> <span>2014</span> </p> <p> <span>Presidential Diversity Award.</span> <span>2013</span> </p> <p> <span>Batsheva de Rothschild Fellow of the Israel Academy of Sciences and Humanities.</span> <span>2013</span> </p> <p> <span>MERIT Award from the NIH GM.</span> <span>2013</span> </p> <p> <span>Elected to the National Academy of Sciences.</span> <span>2011</span> </p> <p> <span>RNA Society Lifetime Achievement Award in Service.</span> <span>2010</span> </p> <p> <span>Elected to the American Association for the Advancement of Science.</span> <span>2006</span> </p> <p> <span>Elected to the American Academy of Arts and Sciences.</span> <span>2006</span> </p> <p> <span>Davey Memorial Award for Outstanding Cancer Research.</span> <span>2002</span> </p> <p> <span>RPI/RNA Award for most significant paper co-authored by a junior scientist published in RNA.</span> <span>1998</span> </p> <p> <span>Exemplary "Woman in Government".</span> <span>1990</span> </p> <p> <span>American Heart Association Established Investigatorship.</span> <span>1985 - 1989</span> </p> </div> </div> </div> <button @click="awardsExpanded = ! awardsExpanded" class="text-pacific-blue hover:underline flex items-center font-semibold mx-auto mt-3"> <svg xmlns="http://www.w3.org/2000/svg" class="h-5 w-5 mr-3.5 transition-all" :class="{ 'rotate-180': awardsExpanded }" fill="none" viewBox="0 0 24 24" stroke="currentColor" stroke-width="2"> <path stroke-linecap="round" stroke-linejoin="round" d="M19 9l-7 7-7-7" /> </svg> <span>View all 26 awards</span> </button> </div> </div> </div> </section> <section class="scroll-mt-36" id="research" x-intersect:enter.margin.-50%="locationsActive = false, insuranceActive = false, aboutActive = false, credentialsActive = false, researchActive = true, publicationsActive = false, ratingsActive = false"> <h2 class="mb-6">Research</h2> <div class="space-y-8"> <div x-data="{ researchBioExpanded: false }"> <div class="relative"> <div x-show="!researchBioExpanded"> <div>Research in my lab focuses on RNA metabolism in human health and disease pathways. One pathway, called nonsense-mediated mRNA decay (NMD) or mRNA surveillance, surveys all newly synthesized mRNAs during what we call a "pioneer" round of translation. This round of translation involves mRNA that is as...</div> </div> </div> <div class="relative"> <div x-cloak x-show="researchBioExpanded"> <div>Research in my lab focuses on RNA metabolism in human health and disease pathways. One pathway, called nonsense-mediated mRNA decay (NMD) or mRNA surveillance, surveys all newly synthesized mRNAs during what we call a "pioneer" round of translation. This round of translation involves mRNA that is associated with the cap-binding heterodimer CBP80 and CBP20. It is distinct from the type of translation that supports the bulk of cellular protein synthesis and involves a different cap-binding protein, eukaryotic initiation factor (eIF) 4E. Generally, if translation terminates more than 50-55 nt upstream of an exon-exon junction that is marked by the NMD factors Upf3 or Upf3X, Upf2 and ultimately Upf1, then the mRNA will be subject to NMD. By the time CBP80 and CBP20 have been replaced by eIF4E, the Upf mark has been removed so that mRNA is largely immune to NMD. Studies in progress will significantly advance our understanding of the mRNP proteins, translation factors and nucleases that trigger NMD. Our results will be useful when designing therapies that aim to abrogate NMD in order to abrogate the severity of nonsense-generated diseases. We are also interested in further characterizing the pioneer translation initiation complex and requirements for its remodeling to the steady-state initiation complex that involves eIF4E. Additionally, we are interested in the cycle of posttranslational modifications that typify at least some of the NMD factors, including phosphorylation of Upf1 that is mediated by the PI 3-kinase-related protein kinase Smg1.<br><br>Over the past 15 years, our discovery and subsequent work on the mechanism of Staufen (Stau)-mediated mRNA decay (SMD) has uncovered new roles for cytoplasmic long non-coding RNAs (lncRNAs) and retrotransposon-derived short interspersed elements (SINEs) in post-transcriptional gene regulation. These SINEs include human Alu elements and mouse B1, B2, B4 and ID elements. We have shown that NMD and SMD are competitive pathways in ways that contribute to cellular homeostasis and also differentiation. We continue to define new cellular roles for SINEs as sites for nucleating intermolecular base-pairing between different mRNAs, between mRNAs and lncRNAs, and between different lncRNAs. We are additionally extending our studies of inverted-repeat Alu elements (IRAlus) and how competitive binding among the many nuclear and cytoplasmic double-stranded RNA binding proteins influence nuclear and cytoplasmic IRAlus-containing RNA metabolism.<br><br>Most recently, we have discovered a new microRNA decay pathway that is mediated by Tudor-SN. This pathway, which we call TumiD, promotes G1-to-S phase transition by degrading microRNAs that degrade mRNAs encoding proteins that promote this transition. We are currently working on how TumiD is regulated. In the process, we discovered a new microRNA decay pathway that is mediated by Tudor-SN. This pathway, which we call TumiD, promotes G1-to-S phase transition by degrading microRNAs that degrade mRNAs encoding proteins that promote this transition.<br><br>More recent and ongoing projects are described by clicking on "Visit Lab Research Site" linked above.</div> </div> </div> <button @click="researchBioExpanded = ! researchBioExpanded" class="text-pacific-blue hover:underline flex items-center font-semibold mt-3"> <svg xmlns="http://www.w3.org/2000/svg" class="h-5 w-5 mr-3.5 transition-all" :class="{ 'rotate-180': researchBioExpanded }" fill="none" viewBox="0 0 24 24" stroke="currentColor" stroke-width="2"> <path stroke-linecap="round" stroke-linejoin="round" d="M19 9l-7 7-7-7" /> </svg> <span>Read <span x-show="!researchBioExpanded">More</span><span x-cloak x-show="researchBioExpanded">Less</span></span> </button> </div> <div> <h3 class="mb-4">Patents</h3> <div class="space-y-6" x-data="{ patentsExpanded: false }"> <div class="pb-6 border-b-2 border-bg-stone-200" x-data="{ showPatent: false }"> <p class="mt-2 font-extrabold text-midnight-blue">Methods and Compositions Related to Staufen 1 Binding Sites Formed By Duplexing ALU Elements</p> <p class="mt-2"><span class="font-bold">Issue date:</span> December 08, 2015</p> <div x-show="showPatent" x-collapse> <p class="mt-2"><span class="font-bold">Patent #:</span> 9,206,479</p> <p class="mt-2"><span class="font-bold">Country:</span> United States</p> <p class="mt-2"><span class="font-bold">Inventors:</span> Chenguang Gong, Lynne Elizabeth Maquat</p> </div> <button @click="showPatent = ! showPatent" class="text-pacific-blue hover:underline flex items-center font-semibold mt-3"> <svg xmlns="http://www.w3.org/2000/svg" class="h-5 w-5 mr-3.5 transition-all" :class="{ 'rotate-180': showPatent }" fill="none" viewBox="0 0 24 24" stroke="currentColor" stroke-width="2"> <path stroke-linecap="round" stroke-linejoin="round" d="M19 9l-7 7-7-7" /> </svg> <span><span x-show="!showPatent">Show </span><span x-show="showPatent">Hide </span> detail</span> </button> </div> </div> </div> </div> </section> <section class="scroll-mt-36" id="publications" x-intersect:enter.margin.-50%="locationsActive = false, insuranceActive = false, aboutActive = false, credentialsActive = false, researchActive = false, publicationsActive = true, ratingsActive = false"> <h2 class="mb-6">Publications</h2> <div class="space-y-8"> <div> <h3 class="mb-4">Journal Articles</h3> <div class="space-y-2" x-data="{ journalArticlesExpanded: false }"> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/39667907"><span>Exploring the therapeutic potential of modulating nonsense-mediated mRNA decay.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">McMahon M, Maquat LE</p> <p class="mt-2">RNA.. 2024 December 12 Epub 12/12/2024.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/38637632"><span>Nuclear mRNA decay: regulatory networks that control gene expression.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Rambout X, Maquat LE</p> <p class="mt-2">Nature reviews. Genetics.. 2024 October 25 (10):679-697. Epub 04/18/2024.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/38352429"><span>ALS-Associated TDP-43 Dysfunction Compromises UPF1-Dependent mRNA Metabolism Pathways Including Alternative Polyadenylation and 3'UTR Length.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Alessandrini F, Wright M, Kurosaki T, Maquat LE, Kiskinis E</p> <p class="mt-2">bioRxiv : the preprint server for biology.. 2024 February 2 Epub 02/02/2024.</p> </div> <div class="relative"> <div x-cloak x-show="journalArticlesExpanded" x-collapse.min.56px> <div class="absolute inset-x-0 bottom-0 bg-gradient-to-b from-transparent to-white ease-in duration-150 z-10" :class="{ 'h-0': journalArticlesExpanded, 'h-14': !journalArticlesExpanded }"></div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/38263082"><span>FMRP-mediated spatial regulation of physiologic NMD targets in neuronal cells.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Kurosaki T, Rambout X, Maquat LE</p> <p class="mt-2">Genome biology.. 2024 January 2325 (1):31. Epub 01/23/2024.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/36669479"><span>PGC-1? senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Rambout X, Cho H, Blanc R, Lyu Q, Miano JM, Chakkalakal JV, Nelson GM, Yalamanchili HK, Adelman K, Maquat LE</p> <p class="mt-2">Molecular cell.. 2023 January 1983 (2):186-202.e11. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/36356584"><span>Integrative omics indicate FMRP sequesters mRNA from translation and deadenylation in human neuronal cells.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Kurosaki T, Mitsutomi S, Hewko A, Akimitsu N, Maquat LE</p> <p class="mt-2">Molecular cell.. 2022 December 182 (23):4564-4581.e11. Epub 11/09/2022.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/35675814"><span>AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Cho H, Abshire ET, Popp MW, Pröschel C, Schwartz JL, Yeo GW, Maquat LE</p> <p class="mt-2">Molecular cell.. 2022 August 482 (15):2779-2796.e10. Epub 06/07/2022.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/35532806"><span>Lessons from the functional characterization of lncRNAs: introduction to mammalian genome special issue.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat L, Johnson R, Valadkhan S, Carninci P</p> <p class="mt-2">Mammalian genome : official journal of the International Mammalian Genome Society.. 2022 June 33 (2):245-247. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/34791665"><span>Noncoding RNAs: biology and applications-a Keystone Symposia report.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Cable J, Heard E, Hirose T, Prasanth KV, Chen LL, Henninger JE, Quinodoz SA, Spector DL, Diermeier SD, Porman AM, Kumar D, Feinberg MW, Shen X, Unfried JP, Johnson R, Chen CK, Wilusz JE, Lempradl A, McGeary SE, Wahba L, Pyle AM, Hargrove AE, Simon MD, Marcia M, Przanowska RK, Chang HY, Jaffrey SR, Contreras LM, Chen Q, Shi J, Mendell JT, He L, Song E, Rinn JL, Lalwani MK, Kalem MC, Chuong EB, Maquat LE, Liu X</p> <p class="mt-2">Annals of the New York Academy of Sciences.. 2021 December 1506 (1):118-141. Epub 11/17/2021.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/34784943"><span>NMD abnormalities during brain development in the Fmr1-knockout mouse model of fragile X syndrome.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Kurosaki T, Sakano H, Pröschel C, Wheeler J, Hewko A, Maquat LE</p> <p class="mt-2">Genome biology.. 2021 November 1622 (1):317. 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Epub 04/04/2013.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/23524536"><span>Staufen1 dimerizes through a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Gleghorn ML, Gong C, Kielkopf CL, Maquat LE</p> <p class="mt-2">Nature structural & molecular biology.. 2013 April 20 (4):515-24. 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Epub 08/05/2010.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/20691898"><span>The pioneer round of translation: features and functions.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE, Tarn WY, Isken O</p> <p class="mt-2">Cell.. 2010 August 6142 (3):368-74. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/21447822"><span>CBP80-promoted mRNP rearrangements during the pioneer round of translation, nonsense-mediated mRNA decay, and thereafter.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE, Hwang J, Sato H, Tang Y</p> <p class="mt-2">Cold Spring Harbor symposia on quantitative biology.. 2010 75 :127-34. Epub 03/29/2011.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/19909264"><span>Gene expression networks: competing mRNA decay pathways in mammalian cells.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE, Gong C</p> <p class="mt-2">Biochemical Society transactions.. 2009 December 37 (Pt 6):1287-92. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/19884259"><span>Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Sato H, Maquat LE</p> <p class="mt-2">Genes & development.. 2009 November 123 (21):2537-50. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/19729311"><span>Re-capping the message.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Schoenberg DR, Maquat LE</p> <p class="mt-2">Trends in biochemical sciences.. 2009 September 34 (9):435-42. Epub 09/02/2009.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/19095803"><span>SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Gong C, Kim YK, Woeller CF, Tang Y, Maquat LE</p> <p class="mt-2">Genes & development.. 2009 January 123 (1):54-66. Epub 12/18/2008.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/20376293"><span>Telomeric RNAs as a novel player in telomeric integrity.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Isken O, Maquat LE</p> <p class="mt-2">F1000 biology reports. 2009 1 :90. Epub 11/26/2009.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/18679436"><span>The multiple lives of NMD factors: balancing roles in gene and genome regulation.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Isken O, Maquat LE</p> <p class="mt-2">Nature reviews. Genetics.. 2008 September 9 (9):699-712. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/18443041"><span>Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Saltzman AL, Kim YK, Pan Q, Fagnani MM, Maquat LE, Blencowe BJ</p> <p class="mt-2">Molecular and cellular biology.. 2008 July 28 (13):4320-30. Epub 04/28/2008.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/18369367"><span>NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Woeller CF, Gaspari M, Isken O, Maquat LE</p> <p class="mt-2">EMBO reports.. 2008 May 9 (5):446-51. Epub 03/28/2008.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/18423202"><span>Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Isken O, Kim YK, Hosoda N, Mayeur GL, Hershey JW, Maquat LE</p> <p class="mt-2">Cell.. 2008 April 18133 (2):314-27. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/18243119"><span>Efficiency of the pioneer round of translation affects the cellular site of nonsense-mediated mRNA decay.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Sato H, Hosoda N, Maquat LE</p> <p class="mt-2">Molecular cell.. 2008 February 129 (2):255-62. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/19111167"><span>RNA turnover in eukaryotes: nucleases, pathways and analysis of mRNA decay. Preface.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE, Kiledjian M</p> <p class="mt-2">Methods in enzymology.. 2008 448 :xxi-xxii. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/19161834"><span>RNA turnover in prokaryotes, archaea and organelles. Preface.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE, Arraiano CM</p> <p class="mt-2">Methods in enzymology.. 2008 447 :xxiii-xxiv. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/19215750"><span>RNA turnover in eukaryotes: analysis of specialized and quality control RNA decay pathways. Preface.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE, Kiledjian M</p> <p class="mt-2">Methods in enzymology.. 2008 449 :xvii-xviii. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/19215759"><span>Chapter 9. Studying nonsense-mediated mRNA decay in mammalian cells.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Matsuda D, Sato H, Maquat LE</p> <p class="mt-2">Methods in enzymology.. 2008 449 :177-201. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/17873884"><span>Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Matsuda D, Hosoda N, Kim YK, Maquat LE</p> <p class="mt-2">Nature structural & molecular biology.. 2007 October 14 (10):974-9. Epub 09/16/2007.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/17671086"><span>Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Isken O, Maquat LE</p> <p class="mt-2">Genes & development.. 2007 August 121 (15):1833-56. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/17510634"><span>Staufen1 regulates diverse classes of mammalian transcripts.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Kim YK, Furic L, Parisien M, Major F, DesGroseillers L, Maquat LE</p> <p class="mt-2">The EMBO journal.. 2007 June 626 (11):2670-81. Epub 05/17/2007.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/16782405"><span>Applying nonsense-mediated mRNA decay research to the clinic: progress and challenges.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Kuzmiak HA, Maquat LE</p> <p class="mt-2">Trends in molecular medicine.. 2006 July 12 (7):306-16. Epub 06/16/2006.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/16581783"><span>Evidence that poly(A) binding protein C1 binds nuclear pre-mRNA poly(A) tails.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Hosoda N, Lejeune F, Maquat LE</p> <p class="mt-2">Molecular and cellular biology.. 2006 April 26 (8):3085-97. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/16418482"><span>Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Pan Q, Saltzman AL, Kim YK, Misquitta C, Shai O, Maquat LE, Frey BJ, Blencowe BJ</p> <p class="mt-2">Genes & development.. 2006 January 1520 (2):153-8. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/16186820"><span>CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Hosoda N, Kim YK, Lejeune F, Maquat LE</p> <p class="mt-2">Nature structural & molecular biology.. 2005 October 12 (10):893-901. Epub 09/25/2005.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/15901502"><span>Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Lejeune F, Maquat LE</p> <p class="mt-2">Current opinion in cell biology.. 2005 June 17 (3):309-15. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/15860725"><span>Nonsense-mediated mRNA decay in mammals.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE</p> <p class="mt-2">Journal of cell science.. 2005 May 1118 (Pt 9):1773-6. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/15753296"><span>Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Gao Q, Das B, Sherman F, Maquat LE</p> <p class="mt-2">Proceedings of the National Academy of Sciences of the United States of America.. 2005 March 22102 (12):4258-63. Epub 03/07/2005.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/15680326"><span>Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Kim YK, Furic L, Desgroseillers L, Maquat LE</p> <p class="mt-2">Cell.. 2005 January 28120 (2):195-208. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/15519847"><span>An enemy within: fly reconnaissance deploys an endonuclease to destroy nonsense-containing mRNA.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Valencia-Sánchez MA, Maquat LE</p> <p class="mt-2">Trends in cell biology.. 2004 November 14 (11):594-7. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/15361857"><span>eIF4G is required for the pioneer round of translation in mammalian cells.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Lejeune F, Ranganathan AC, Maquat LE</p> <p class="mt-2">Nature structural & molecular biology.. 2004 October 11 (10):992-1000. Epub 09/07/2004.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/15175154"><span>The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Brumbaugh KM, Otterness DM, Geisen C, Oliveira V, Brognard J, Li X, Lejeune F, Tibbetts RS, Maquat LE, Abraham RT</p> <p class="mt-2">Molecular cell.. 2004 June 414 (5):585-98. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/15059963"><span>The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Chiu SY, Lejeune F, Ranganathan AC, Maquat LE</p> <p class="mt-2">Genes & development.. 2004 April 118 (7):745-54. Epub 04/01/2004.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/15040442"><span>Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE</p> <p class="mt-2">Nature reviews. Molecular cell biology.. 2004 February 5 (2):89-99. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/14770001"><span>Immunopurification and analysis of protein and RNA components of mRNP in mammalian cells.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Lejeune F, Maquat LE</p> <p class="mt-2">Methods in molecular biology.. 2004 257 :115-24. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/14527413"><span>Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Lejeune F, Li X, Maquat LE</p> <p class="mt-2">Molecular cell.. 2003 September 12 (3):675-87. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/12823827"><span>Post-transcriptional control of gene expression: effectors of mRNA decay.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Arraiano CM, Maquat LE</p> <p class="mt-2">Molecular microbiology.. 2003 July 49 (1):267-76. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/12554878"><span>Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Chiu SY, Serin G, Ohara O, Maquat LE</p> <p class="mt-2">RNA.. 2003 January 9 (1):77-87. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/12242335"><span>Beta -Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Stevens A, Wang Y, Bremer K, Zhang J, Hoepfner R, Antoniou M, Schoenberg DR, Maquat LE</p> <p class="mt-2">Proceedings of the National Academy of Sciences of the United States of America.. 2002 October 199 (20):12741-6. Epub 09/19/2002.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/12130534"><span>NASty effects on fibrillin pre-mRNA splicing: another case of ESE does it, but proposals for translation-dependent splice site choice live on.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE</p> <p class="mt-2">Genes & development.. 2002 July 1516 (14):1743-53. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/12093754"><span>The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Lejeune F, Ishigaki Y, Li X, Maquat LE</p> <p class="mt-2">The EMBO journal.. 2002 July 121 (13):3536-45. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/11910094"><span>Molecular biology. Skiing toward nonstop mRNA decay.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE</p> <p class="mt-2">Science.. 2002 March 22295 (5563):2221-2. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/11909543"><span>Nonsense-mediated mRNA decay.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE</p> <p class="mt-2">Current biology : CB.. 2002 March 1912 (6):R196-7. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/12054885"><span>RNA-protein interactions: insight into gene function.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE</p> <p class="mt-2">Methods : a companion to Methods in enzymology.. 2002 February 26 (2):93-4. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <p class="mt-2 font-bold">Nonsense-Mediated Decay: Assaying for Effects on Selenoprotein mRNAs</p> <p class="mt-2">Sun, X.; Maquat, L.E. ;.</p> <p class="mt-2">In Methods in Enzymology. Protein Sensors of Reactive Oxygen Species: Selenoproteins, Thioredoxin, Thiol Enzymes, and Proteins, eds. H. Sies, L. Packer, Academic Press. 2002; 347(3): 49-57.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/11898438"><span>Nonsense-mediated decay: assaying for effects on selenoprotein mRNAs.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Sun X, Maquat LE</p> <p class="mt-2">Methods in enzymology.. 2002 347 :49-57. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/11710333"><span>New ways of initiating translation in eukaryotes.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donzé O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M, Gehrke L, Goldman E, Groner Y, Harford JB, Hatzglou M, He B, Hellen CU, Hentze MW, Hershey J, Hershey P, Hohn T, Holcik M, Hunter CP, Igarashi K, Jackson R, Jagus R, Jefferson LS, Joshi B, Kaempfer R, Katze M, Kaufman RJ, Kiledjian M, Kimball SR, Kimchi A, Kirkegaard K, Koromilas AE, Krug RM, Kruys V, Lamphear BJ, Lemon S, Lloyd RE, Maquat LE, Martinez-Salas E, Mathews MB, Mauro VP, Miyamoto S, Mohr I, Morris DR, Moss EG, Nakashima N, Palmenberg A, Parkin NT, Pe'ery T, Pelletier J, Peltz S, Pestova TV, Pilipenko EV, Prats AC, Racaniello V, Read GS, Rhoads RE, Richter JD, Rivera-Pomar R, Rouault T, Sachs A, Sarnow P, Scheper GC, Schiff L, Schoenberg DR, Semler BL, Siddiqui A, Skern T, Sonenberg N, Sossin W, Standart N, Tahara SM, Thomas AA, Toulmé JJ, Wilusz J, Wimmer E, Witherell G, Wormington M</p> <p class="mt-2">Molecular and cellular biology.. 2001 December 21 (23):8238-46. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/11551508"><span>Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Ishigaki Y, Li X, Serin G, Maquat LE</p> <p class="mt-2">Cell.. 2001 September 7106 (5):607-17. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/11331269"><span>Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP</p> <p class="mt-2">The Journal of biological chemistry.. 2001 June 22276 (25):22709-14. Epub 04/30/2001.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/11294903"><span>Nonsense-mediated decay of mRNA for the selenoprotein phospholipid hydroperoxide glutathione peroxidase is detectable in cultured cells but masked or inhibited in rat tissues.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Sun X, Li X, Moriarty PM, Henics T, LaDuca JP, Maquat LE</p> <p class="mt-2">Molecular biology of the cell.. 2001 April 12 (4):1009-17. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/11333024"><span>Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE, Li X</p> <p class="mt-2">RNA.. 2001 March 7 (3):445-56. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/11207359"><span>Quality control of mRNA function.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE, Carmichael GG</p> <p class="mt-2">Cell.. 2001 January 26104 (2):173-6. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/11113196"><span>Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4).</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Serin G, Gersappe A, Black JD, Aronoff R, Maquat LE</p> <p class="mt-2">Molecular and cellular biology.. 2001 January 21 (1):209-23. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/11137984"><span>The power of point mutations.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE</p> <p class="mt-2">Nature genetics.. 2001 January 27 (1):5-6. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/11214180"><span>Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Pal M, Ishigaki Y, Nagy E, Maquat LE</p> <p class="mt-2">RNA.. 2001 January 7 (1):5-15. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/11568438"><span>Evidence that selenium deficiency results in the cytoplasmic decay of GPx1 mRNA dependent on pre-mRNA splicing proteins bound to the mRNA exon-exon junction.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE</p> <p class="mt-2">BioFactors.. 2001 14 (1-4):37-42. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/12762033"><span>Nonsense-mediated mRNA decay: insights into mechanism from the cellular abundance of human Upf1, Upf2, Upf3, and Upf3X proteins.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE, Serin G</p> <p class="mt-2">Cold Spring Harbor symposia on quantitative biology.. 2001 66 :313-20. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/11118221"><span>The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Le Hir H, Izaurralde E, Maquat LE, Moore MJ</p> <p class="mt-2">The EMBO journal.. 2000 December 1519 (24):6860-9. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/10970865"><span>Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Sun X, Moriarty PM, Maquat LE</p> <p class="mt-2">The EMBO journal.. 2000 September 119 (17):4734-44. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/10809668"><span>Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Le Hir H, Moore MJ, Maquat LE</p> <p class="mt-2">Genes & development.. 2000 May 114 (9):1098-108. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/10782327"><span>Identical germ-line mutations in the triosephosphate isomerase alleles of two brothers are associated with distinct clinical phenotypes.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Valentin C, Cohen-Solal M, Maquat L, Horányi M, Inselt-Kovács M, Hollán S</p> <p class="mt-2">Comptes rendus de l'Académie des sciences. Série III, Sciences de</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/10668793"><span>mRNA surveillance in mammalian cells: the relationship between introns and translation termination.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Sun X, Maquat LE</p> <p class="mt-2">RNA.. 2000 January 6 (1):1-8. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/9710612"><span>At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Zhang J, Sun X, Qian Y, LaDuca JP, Maquat LE</p> <p class="mt-2">Molecular and cellular biology.. 1998 September 18 (9):5272-83. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/9707591"><span>A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Sun X, Perlick HA, Dietz HC, Maquat LE</p> <p class="mt-2">Proceedings of the National Academy of Sciences of the United States of America.. 1998 August 1895 (17):10009-14. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/9671053"><span>Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Zhang J, Sun X, Qian Y, Maquat LE</p> <p class="mt-2">RNA.. 1998 July 4 (7):801-15. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/9644970"><span>A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Nagy E, Maquat LE</p> <p class="mt-2">Trends in biochemical sciences.. 1998 June 23 (6):198-9. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/9566912"><span>Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Moriarty PM, Reddy CC, Maquat LE</p> <p class="mt-2">Molecular and cellular biology.. 1998 May 18 (5):2932-9. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/9404888"><span>The presence of an intron within the rat gene for selenium-dependent glutathione peroxidase 1 is not required to protect nuclear RNA from UGA-mediated decay.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Moriarty PM, Reddy CC, Maquat LE</p> <p class="mt-2">RNA.. 1997 December 3 (12):1369-73. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/9049311"><span>Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Zhang J, Maquat LE</p> <p class="mt-2">The EMBO journal.. 1997 February 1716 (4):826-33. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/8755945"><span>Defects in RNA splicing and the consequence of shortened translational reading frames.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE</p> <p class="mt-2">American journal of human genetics.. 1996 August 59 (2):279-86. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/8608447"><span>Evidence that the decay of nucleus-associated nonsense mRNA for human triosephosphate isomerase involves nonsense codon recognition after splicing.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Zhang J, Maquat LE</p> <p class="mt-2">RNA.. 1996 March 2 (3):235-43. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/9150883"><span>Cytoplasmic mRNA for human triosephosphate isomerase is immune to nonsense-mediated decay despite forming polysomes.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Stephenson LS, Maquat LE</p> <p class="mt-2">Biochimie.. 1996 78 (11-12):1043-7. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/7489507"><span>When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE</p> <p class="mt-2">RNA.. 1995 July 1 (5):453-65. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/7799958"><span>Lack of an effect of the efficiency of RNA 3'-end formation on the efficiency of removal of either the final or the penultimate intron in intact cells.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Nesic D, Zhang J, Maquat LE</p> <p class="mt-2">Molecular and cellular biology.. 1995 January 15 (1):488-96. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/7969159"><span>Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Belgrader P, Cheng J, Zhou X, Stephenson LS, Maquat LE</p> <p class="mt-2">Molecular and cellular biology.. 1994 December 14 (12):8219-28. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/8065363"><span>Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Cheng J, Belgrader P, Zhou X, Maquat LE</p> <p class="mt-2">Molecular and cellular biology.. 1994 September 14 (9):6317-25. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/8065364"><span>Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Belgrader P, Maquat LE</p> <p class="mt-2">Molecular and cellular biology.. 1994 September 14 (9):6326-36. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/7906237"><span>Upstream introns influence the efficiency of final intron removal and RNA 3'-end formation.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Nesic D, Maquat LE</p> <p class="mt-2">Genes & development.. 1994 February 18 (3):363-75. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/7684497"><span>Sequences within the last intron function in RNA 3'-end formation in cultured cells.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Nesic D, Cheng J, Maquat LE</p> <p class="mt-2">Molecular and cellular biology.. 1993 June 13 (6):3359-69. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/8503454"><span>Human triosephosphate isomerase deficiency resulting from mutation of Phe-240.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Chang ML, Artymiuk PJ, Wu X, Hollán S, Lammi A, Maquat LE</p> <p class="mt-2">American journal of human genetics.. 1993 June 52 (6):1260-9. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/8441420"><span>Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Cheng J, Maquat LE</p> <p class="mt-2">Molecular and cellular biology.. 1993 March 13 (3):1892-902. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/8421679"><span>Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Belgrader P, Cheng J, Maquat LE</p> <p class="mt-2">Proceedings of the National Academy of Sciences of the United States of America.. 1993 January 1590 (2):482-6. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/1324170"><span>Human beta-globin mRNAs that harbor a nonsense codon are degraded in murine erythroid tissues to intermediates lacking regions of exon I or exons I and II that have a cap-like structure at the 5' termini.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Lim SK, Maquat LE</p> <p class="mt-2">The EMBO journal.. 1992 September 11 (9):3271-8. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/1545796"><span>Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Lim SK, Sigmund CD, Gross KW, Maquat LE</p> <p class="mt-2">Molecular and cellular biology.. 1992 March 12 (3):1149-61. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/1814360"><span>Nuclear mRNA export.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE</p> <p class="mt-2">Current opinion in cell biology.. 1991 December 3 (6):1004-12. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/2071606"><span>Modulation of human triosephosphate isomerase gene transcription by serum.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Boyer TG, Maquat LE</p> <p class="mt-2">The Journal of biological chemistry.. 1991 July 15266 (20):13350-4. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/2243103"><span>Minimal sequence and factor requirements for the initiation of transcription from an atypical, TATATAA box-containing housekeeping promoter.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Boyer TG, Maquat LE</p> <p class="mt-2">The Journal of biological chemistry.. 1990 November 25265 (33):20524-32. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/2398889"><span>Translation to near the distal end of the penultimate exon is required for normal levels of spliced triosephosphate isomerase mRNA.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Cheng J, Fogel-Petrovic M, Maquat LE</p> <p class="mt-2">Molecular and cellular biology.. 1990 October 10 (10):5215-25. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/2377473"><span>Nucleotide sequence of murine triosephosphate isomerase cDNA.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Cheng J, Mielnicki LM, Pruitt SC, Maquat LE</p> <p class="mt-2">Nucleic acids research.. 1990 July 2518 (14):4261. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/2573525"><span>Novel metabolism of several beta zero-thalassemic beta-globin mRNAs in the erythroid tissues of transgenic mice.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Lim S, Mullins JJ, Chen CM, Gross KW, Maquat LE</p> <p class="mt-2">The EMBO journal.. 1989 September 8 (9):2613-9. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/2925688"><span>Transcriptional regulatory sequences of the housekeeping gene for human triosephosphate isomerase.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Boyer TG, Krug JR, Maquat LE</p> <p class="mt-2">The Journal of biological chemistry.. 1989 March 25264 (9):5177-87. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/2832737"><span>Premature translation termination mediates triosephosphate isomerase mRNA degradation.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Daar IO, Maquat LE</p> <p class="mt-2">Molecular and cellular biology.. 1988 February 8 (2):802-13. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/2876430"><span>Human triose-phosphate isomerase deficiency: a single amino acid substitution results in a thermolabile enzyme.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Daar IO, Artymiuk PJ, Phillips DC, Maquat LE</p> <p class="mt-2">Proceedings of the National Academy of Sciences of the United States of America.. 1986 October 83 (20):7903-7. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/3023939"><span>Localization of DNA sequences involved in dexamethasone-dependent expression of the rat alpha 1-acid glycoprotein gene.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Baumann H, Maquat LE</p> <p class="mt-2">Molecular and cellular biology.. 1986 July 6 (7):2551-61. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/4022011"><span>Characterization of the functional gene and several processed pseudogenes in the human triosephosphate isomerase gene family.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Brown JR, Daar IO, Krug JR, Maquat LE</p> <p class="mt-2">Molecular and cellular biology.. 1985 July 5 (7):1694-706. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/2582366"><span>A beta zero-thalassemic beta-globin RNA that is labile in bone marrow cells is relatively stable in HeLa cells.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE, Kinniburgh AJ</p> <p class="mt-2">Nucleic acids research.. 1985 April 2513 (8):2855-67. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/2579079"><span>Human triosephosphate isomerase cDNA and protein structure. Studies of triosephosphate isomerase deficiency in man.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE, Chilcote R, Ryan PM</p> <p class="mt-2">The Journal of biological chemistry.. 1985 March 25260 (6):3748-53. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/6292840"><span>mRNA-deficient beta o-thalassemia results from a single nucleotide deletion.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Kinniburgh AJ, Maquat LE, Schedl T, Rachmilewitz E, Ross J</p> <p class="mt-2">Nucleic acids research.. 1982 September 2510 (18):5421-7. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/6101206"><span>Unstable beta-globin mRNA in mRNA-deficient beta o thalassemia.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE, Kinniburgh AJ, Rachmilewitz EA, Ross J</p> <p class="mt-2">Cell.. 1981 December 27 (3 Pt 2):543-53. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/6933479"><span>Processing of human beta-globin mRNA precursor to mRNA is defective in three patients with beta+-thalassemia.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE, Kinniburgh AJ, Beach LR, Honig GR, Lazerson J, Ershler WB, Ross J</p> <p class="mt-2">Proceedings of the National Academy of Sciences of the United States of America.. 1980 July 77 (7):4287-91. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/6160250"><span>lac Promoter mutation Pr115 generates a new transcription initiation point.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE, Reznikoff WS</p> <p class="mt-2">Journal of molecular biology.. 1980 May 25139 (3):551-6. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/6777500"><span>lac Promoter mutations located downstream from the transcription start site.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE, Thornton K, Reznikoff WS</p> <p class="mt-2">Journal of molecular biology.. 1980 May 25139 (3):537-49. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/376513"><span>Influence of A-T content on the fractionation of DNA restriction fragments by RPC-5 column chromatography.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Patient RK, Hardies SC, Larson JE, Inman RB, Maquat LE, Wells RD</p> <p class="mt-2">The Journal of biological chemistry.. 1979 June 25254 (12):5548-54. Epub 1900 01 01.</p> </div> <div class="pb-6 border-b-2 border-bg-stone-200"> <a class="text-navy-blue btn-link inline hover:text-pacific-blue append-icon" href="http://www.ncbi.nlm.nih.gov/pubmed/368341"><span>In vitro analysis of the Escherichia coli RNA polymerase interaction with wild-type and mutant lactose promoters.</span><svg xmlns="http://www.w3.org/2000/svg" class="inline-block w-5 h-5 fill-current" viewBox="0 0 448 512"> <path d="M280 80C266.7 80 256 69.25 256 56C256 42.75 266.7 32 280 32H424C437.3 32 448 42.75 448 56V200C448 213.3 437.3 224 424 224C410.7 224 400 213.3 400 200V113.9L200.1 312.1C191.6 322.3 176.4 322.3 167 312.1C157.7 303.6 157.7 288.4 167 279L366.1 80H280zM0 120C0 89.07 25.07 64 56 64H168C181.3 64 192 74.75 192 88C192 101.3 181.3 112 168 112H56C51.58 112 48 115.6 48 120V424C48 428.4 51.58 432 56 432H360C364.4 432 368 428.4 368 424V312C368 298.7 378.7 288 392 288C405.3 288 416 298.7 416 312V424C416 454.9 390.9 480 360 480H56C25.07 480 0 454.9 0 424V120z" /> </svg></a> <p class="mt-2">Maquat LE, Reznikoff WS</p> <p class="mt-2">Journal of molecular biology.. 1978 November 15125 (4):467-90. 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Lynne E. Maquat, Ph.D. | UR Medicine