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47.8 92.2 47.6 35.7.3 72-32.8 92.3-47.6 102-74.1 131.6-96.3 154-113.7zM256 320c23.2.4 56.6-29.2 73.4-41.4 132.7-96.3 142.8-104.7 173.4-128.7 5.8-4.5 9.2-11.5 9.2-18.9v-19c0-26.5-21.5-48-48-48H48C21.5 64 0 85.5 0 112v19c0 7.4 3.4 14.3 9.2 18.9 30.6 23.9 40.7 32.4 173.4 128.7 16.8 12.2 50.2 41.8 73.4 41.4z"></path></svg> </span> </div> </div> </div> </div> </div> </div> </div> <div class="elementor-element elementor-element-c546def elementor-widget elementor-widget-theme-post-featured-image elementor-widget-image" data-id="c546def" data-element_type="widget" data-widget_type="theme-post-featured-image.default"> <div class="elementor-widget-container"> <figure class="wp-caption"> <img width="1024" height="700" src="data:image/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==" class="attachment-full size-full wp-image-11013 ewww_webp" alt="" data-src-img="https://imapac.com/wp-content/uploads/2024/01/Clinical-Trials-Banner-Advancements-in-Cancer-Vaccines.jpg" data-src-webp="https://imapac.com/wp-content/uploads/2024/01/Clinical-Trials-Banner-Advancements-in-Cancer-Vaccines.jpg.webp" data-eio="j" /><noscript><img width="1024" height="700" src="https://imapac.com/wp-content/uploads/2024/01/Clinical-Trials-Banner-Advancements-in-Cancer-Vaccines.jpg" class="attachment-full size-full wp-image-11013" alt="" /></noscript> <figcaption class="widget-image-caption wp-caption-text"></figcaption> </figure> </div> </div> <div class="elementor-element elementor-element-166f2c6 elementor-widget elementor-widget-theme-post-content" data-id="166f2c6" data-element_type="widget" data-widget_type="theme-post-content.default"> <div class="elementor-widget-container"> <p><span style="font-weight: 400;">A Phase I clinical trial has shown encouraging results for a lymph node-targeted cancer vaccine, ELI-002, designed to prevent relapse in KRAS-mutated pancreatic and colorectal cancers. The vaccine, evaluated in the AMPLIFY-201 trial, displayed an 86% reduction in the risk of relapse or death. T cell responses were observed in 84% of patients, reaching 100% in the two highest dose cohorts, particularly those receiving the recommended Phase II dose of 10mg.</span></p> <p><span style="font-weight: 400;">These T cell responses correlated with significant reductions in tumor biomarkers and circulating tumor DNA (ctDNA) clearance. The study also highlighted a median recurrence-free survival that had not been reached in patients with a T cell response level above the median, compared to 4.01 months in those below the median.</span></p> <p><span style="font-weight: 400;">Dr. Shubham Pant, the principal investigator, expressed optimism about the vaccine’s potential to help patients avoid relapse, potentially increasing overall survival. The trial showcased a favorable safety profile, with no dose-limiting toxicities, cytokine release syndrome, or severe adverse events reported.</span></p> <p><span style="font-weight: 400;">The study is particularly significant for pancreatic cancer patients who remain at risk for relapse post-surgery, especially those positive for ctDNA. The absence of curative options after relapse underscores the urgent need for effective preventive measures.</span></p> <p><span style="font-weight: 400;">Looking ahead, a Phase II trial is slated for 2024, utilizing a new formulation of the ELI-002 cancer vaccine, targeting additional KRAS mutations. Preliminary data from the Phase I trial, presented at the ASCO Annual </span></p> <p><span style="font-weight: 400;">Meeting and AACR Special Conference on Pancreatic Cancer in 2023, has laid a promising foundation for further advancements in cancer vaccine research. The trial received support from Elicio Therapeutics.</span></p> <p> </p> <p><b>Source:</b> <a href="https://www.nature.com/articles/s41591-023-02760-3"><span style="font-weight: 400;">Nature Medicine Journal</span></a><span style="font-weight: 400;">, </span><a href="https://elicio.com/press_releases/elicio-therapeutics-announces-first-patient-dosed-in-randomized-phase-2-pancreatic-cancer-study/"><span style="font-weight: 400;">Elicio Therapeutics</span></a></p> </div> </div> </div> <div class="elementor-element elementor-element-9ccfd6d e-con-full e-flex e-con e-child" data-id="9ccfd6d" data-element_type="container" data-settings="{"jet_parallax_layout_list":[]}"> <div class="elementor-element elementor-element-208900e e-con-full e-flex e-con e-child" data-id="208900e" data-element_type="container" data-settings="{"jet_parallax_layout_list":[],"sticky":"top","sticky_offset":170,"sticky_on":["desktop","tablet","mobile"],"sticky_effects_offset":0}"> <div class="elementor-element 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margin-right: 60px; } </style> </head> <body> <div id="contact-form"> <form id="contact-form"> <p><label> First Name*<br /> <input type="text" id="first-name" name="first-name" required /><br /> </label><br /> <label> Last Name*<br /> <input type="text" id="last-name" name="last-name" required /><br /> </label> </p>  <p><input type="hidden" id="full-name" name="full-name" akismet:author /> </p>  <p><input type="hidden" id="marketing-tag" name="marketing-tag" value="BMG2024_ProgramBrochure" /> </p> <p><label> Email*<br /> <input type="email" id="your-email" name="your-email" autocomplete="email" required akismet:author_email /><br /> </label> </p> <p><span id="wpcf7-673f743f7a5f1-wrapper" class="wpcf7-form-control-wrap email-address-wrap" ><label for="wpcf7-673f743f7a5f1-field" class="hp-message">Please leave this field empty.</label><input id="wpcf7-673f743f7a5f1-field" class="wpcf7-form-control wpcf7-text" type="text" name="email-address" value="" size="40" tabindex="-1" autocomplete="new-password" /></span> </p> <p><label> Contact Number*<br /> <input type="tel" id="phone-number" name="phone-number" autocomplete="tel" required /><br /> </label> </p> <p><label> Job Title*<br /> <input type="text" id="your-job-designation" name="your-job-designation" required /><br /> </label> </p> <p><label> Company*<br /> <input type="text" id="company" name="company" required /><br /> </label> </p> <p>IMAPAC requires your contact information to reach out to you about our products and services. 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