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class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by JUAN LOPEZ</h3></div><div class="js-work-strip profile--work_container" data-work-id="12232190"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12232190/Systems_Biology_of_Tissue_Specific_Response_to_Anaplasma_phagocytophilum_Reveals_Differentiated_Apoptosis_in_the_Tick_Vector_Ixodes_scapularis"><img alt="Research paper thumbnail of Systems Biology of Tissue-Specific Response to Anaplasma phagocytophilum Reveals Differentiated Apoptosis in the Tick Vector Ixodes scapularis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12232190/Systems_Biology_of_Tissue_Specific_Response_to_Anaplasma_phagocytophilum_Reveals_Differentiated_Apoptosis_in_the_Tick_Vector_Ixodes_scapularis">Systems Biology of Tissue-Specific Response to Anaplasma phagocytophilum Reveals Differentiated Apoptosis in the Tick Vector Ixodes scapularis</a></div><div class="wp-workCard_item"><span>PLOS Genetics</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Anaplasma phagocytophilum is an emerging pathogen that causes human granulocytic anaplasmosis. In...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Anaplasma phagocytophilum is an emerging pathogen that causes human granulocytic anaplasmosis. Infection with this zoonotic pathogen affects cell function in both vertebrate host and the tick vector, Ixodes scapularis. Global tissue-specific response and apoptosis signaling pathways were characterized in I. scapularis nymphs and adult female midguts and salivary glands infected with A. phagocytophilum using a systems biology approach combining transcriptomics and proteomics. Apoptosis was selected for pathway-focused analysis due to its role in bacterial infection of tick cells. The results showed tissue-specific differences in tick response to infection and revealed differentiated regulation of apoptosis pathways. The impact of bacterial infection was more pronounced in tick nymphs and midguts than in salivary glands, probably reflecting bacterial developmental cycle. All apoptosis pathways described in other organisms were identified in I. scapularis, except for the absence of the Perforin ortholog. Functional characterization using RNA interference showed that Porin knockdown significantly increases tick colonization by A. phagocytophilum. Infection with A. phagocytophilum produced complex tissue-specific alterations in transcript and protein levels. In tick nymphs, the results suggested a possible effect of bacterial infection on the inhibition of tick immune response. In tick midguts, the results suggested that A. phagocytophilum infection inhibited cell apoptosis to facilitate and establish infection through up-regulation of the JAK/STAT pathway. Bacterial infection inhibited the intrinsic apoptosis pathway in tick salivary glands by down-regulating Porin expression that resulted in the inhibition of Cytochrome c release as the anti-apoptotic mechanism to facilitate bacterial infection. However, tick salivary glands may promote apoptosis to limit bacterial infection through induction of the extrinsic apoptosis pathway. These dynamic changes in response to A. phagocytophilum in I. scapularis tissue-specific transcriptome and proteome demonstrated the complexity of the tick response to infection and will contribute to characterize gene regulation in ticks.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232190"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232190"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232190; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232190]").text(description); $(".js-view-count[data-work-id=12232190]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232190; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232190']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232190, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12232190]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232190,"title":"Systems Biology of Tissue-Specific Response to Anaplasma phagocytophilum Reveals Differentiated Apoptosis in the Tick Vector Ixodes scapularis","translated_title":"","metadata":{"abstract":"Anaplasma phagocytophilum is an emerging pathogen that causes human granulocytic anaplasmosis. Infection with this zoonotic pathogen affects cell function in both vertebrate host and the tick vector, Ixodes scapularis. Global tissue-specific response and apoptosis signaling pathways were characterized in I. scapularis nymphs and adult female midguts and salivary glands infected with A. phagocytophilum using a systems biology approach combining transcriptomics and proteomics. Apoptosis was selected for pathway-focused analysis due to its role in bacterial infection of tick cells. The results showed tissue-specific differences in tick response to infection and revealed differentiated regulation of apoptosis pathways. The impact of bacterial infection was more pronounced in tick nymphs and midguts than in salivary glands, probably reflecting bacterial developmental cycle. All apoptosis pathways described in other organisms were identified in I. scapularis, except for the absence of the Perforin ortholog. Functional characterization using RNA interference showed that Porin knockdown significantly increases tick colonization by A. phagocytophilum. Infection with A. phagocytophilum produced complex tissue-specific alterations in transcript and protein levels. In tick nymphs, the results suggested a possible effect of bacterial infection on the inhibition of tick immune response. In tick midguts, the results suggested that A. phagocytophilum infection inhibited cell apoptosis to facilitate and establish infection through up-regulation of the JAK/STAT pathway. Bacterial infection inhibited the intrinsic apoptosis pathway in tick salivary glands by down-regulating Porin expression that resulted in the inhibition of Cytochrome c release as the anti-apoptotic mechanism to facilitate bacterial infection. However, tick salivary glands may promote apoptosis to limit bacterial infection through induction of the extrinsic apoptosis pathway. 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The results showed tissue-specific differences in tick response to infection and revealed differentiated regulation of apoptosis pathways. The impact of bacterial infection was more pronounced in tick nymphs and midguts than in salivary glands, probably reflecting bacterial developmental cycle. All apoptosis pathways described in other organisms were identified in I. scapularis, except for the absence of the Perforin ortholog. Functional characterization using RNA interference showed that Porin knockdown significantly increases tick colonization by A. phagocytophilum. Infection with A. phagocytophilum produced complex tissue-specific alterations in transcript and protein levels. In tick nymphs, the results suggested a possible effect of bacterial infection on the inhibition of tick immune response. In tick midguts, the results suggested that A. phagocytophilum infection inhibited cell apoptosis to facilitate and establish infection through up-regulation of the JAK/STAT pathway. 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Dichas tensiones se generan durante el crecimiento y maduración de las células producidas año a año por el cambium. En ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232189"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232189"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232189; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232189]").text(description); $(".js-view-count[data-work-id=12232189]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232189; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232189']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232189, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12232189]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232189,"title":"VARIACIÓN DE LAS TENSIONES DE CRECIMIENTO EN TRES CLONES DE Eucalyptus grandis SEGÚN EL ESTADO DE COMPETENCIA INDIVIDUAL","translated_title":"","metadata":{"abstract":"Las tensiones de crecimientos se encuentran en todas las especies forestales, siendo en algunas latifoliadas consideradas como el principal defecto. 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En ...","internal_url":"https://www.academia.edu/12232189/VARIACI%C3%93N_DE_LAS_TENSIONES_DE_CRECIMIENTO_EN_TRES_CLONES_DE_Eucalyptus_grandis_SEG%C3%9AN_EL_ESTADO_DE_COMPETENCIA_INDIVIDUAL","translated_internal_url":"","created_at":"2015-05-04T13:47:04.613-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":30716972,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"VARIACIÓN_DE_LAS_TENSIONES_DE_CRECIMIENTO_EN_TRES_CLONES_DE_Eucalyptus_grandis_SEGÚN_EL_ESTADO_DE_COMPETENCIA_INDIVIDUAL","translated_slug":"","page_count":null,"language":"es","content_type":"Work","owner":{"id":30716972,"first_name":"JUAN","middle_initials":null,"last_name":"LOPEZ","page_name":"JUANLOPEZ","domain_name":"unearte","created_at":"2015-05-04T06:29:21.113-07:00","display_name":"JUAN LOPEZ","url":"https://unearte.academia.edu/JUANLOPEZ"},"attachments":[],"research_interests":[{"id":1426166,"name":"Eucalyptus Grandis","url":"https://www.academia.edu/Documents/in/Eucalyptus_Grandis"}],"urls":[{"id":4738441,"url":"http://www.inta.gov.ar/bellavista/congresos/2007/jor.ftal04.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232188"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/12232188/A_User_Interface_for_the_Design_of_Human_Figures_Multimedia_Animations"><img alt="Research paper thumbnail of A User Interface for the Design of Human Figures Multimedia Animations" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/12232188/A_User_Interface_for_the_Design_of_Human_Figures_Multimedia_Animations">A User Interface for the Design of Human Figures Multimedia Animations</a></div><div class="wp-workCard_item"><span>Hypertext, Information Retrieval, Multimedia</span><span>, 1997</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This paper presents the design and development of a visual computer system for the modelling and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This paper presents the design and development of a visual computer system for the modelling and simulation of human movements. The interface allows human figure movements to be generated in a graphical and intuitive way, accomplishing human-computer interaction through 3D icons-graphics. In the implementation object oriented programming methodology is used. A hierarchical dependency between the members of the human body</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232188"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232188"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232188; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232188]").text(description); $(".js-view-count[data-work-id=12232188]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232188; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232188']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232188, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12232188]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232188,"title":"A User Interface for the Design of Human Figures Multimedia Animations","translated_title":"","metadata":{"abstract":"This paper presents the design and development of a visual computer system for the modelling and simulation of human movements. 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Neutrophils are able to produce extracellular traps (NETs) in response to medically important fungi including Aspergillus spp., Candida albicans and Cryptococcus gattii. However, NET production in response to Paracoccidioides brasiliensis has yet to be studied. We have demonstrated that human neutrophils produce NETs against both conidia and yeasts of P. brasiliensis. Although the NADPH oxidase inhibitor DPI did not alter NET production against conidia, it partially suppressed NET formation against P. brasiliensis yeasts. Cytochalasin-D or IFN-γ did not affect the production of NETs against the fungus. Additionally, a mutant strain of P. brasiliensis with reduced expression of an alternative oxidase (AOX) induced significantly higher levels of NETs in comparison with the wild type strain. Finally, CFU quantification of P. brasiliensis showed no significant d...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="65d1f7dcf4fe44e6e81dfb7ff969ced5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46291434,"asset_id":12232187,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46291434/download_file?st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232187"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232187"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232187; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232187]").text(description); $(".js-view-count[data-work-id=12232187]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232187; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232187']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232187, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "65d1f7dcf4fe44e6e81dfb7ff969ced5" } } $('.js-work-strip[data-work-id=12232187]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232187,"title":"Human neutrophils produce extracellular traps against Paracoccidioides brasiliensis","translated_title":"","metadata":{"abstract":"Neutrophils play an important role as effector cells and contribute to the resistance of the host against microbial pathogens. 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Finally, CFU quantification of P. brasiliensis showed no significant d...","publication_date":{"day":20,"month":1,"year":2015,"errors":{}},"publication_name":"Microbiology (Reading, England)"},"translated_abstract":"Neutrophils play an important role as effector cells and contribute to the resistance of the host against microbial pathogens. Neutrophils are able to produce extracellular traps (NETs) in response to medically important fungi including Aspergillus spp., Candida albicans and Cryptococcus gattii. However, NET production in response to Paracoccidioides brasiliensis has yet to be studied. We have demonstrated that human neutrophils produce NETs against both conidia and yeasts of P. brasiliensis. Although the NADPH oxidase inhibitor DPI did not alter NET production against conidia, it partially suppressed NET formation against P. brasiliensis yeasts. Cytochalasin-D or IFN-γ did not affect the production of NETs against the fungus. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232186"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12232186/The_effect_of_IFN_gamma_and_TNF_alpha_on_the_eosinophilic_differentiation_and_NADPH_oxidase_activation_of_human_HL_60_clone_15_cells"><img alt="Research paper thumbnail of The effect of IFN-gamma and TNF-alpha on the eosinophilic differentiation and NADPH oxidase activation of human HL-60 clone 15 cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12232186/The_effect_of_IFN_gamma_and_TNF_alpha_on_the_eosinophilic_differentiation_and_NADPH_oxidase_activation_of_human_HL_60_clone_15_cells">The effect of IFN-gamma and TNF-alpha on the eosinophilic differentiation and NADPH oxidase activation of human HL-60 clone 15 cells</a></div><div class="wp-workCard_item"><span>Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of this study was to investigate the effect of interferon-gamma (IFN-gamma) and tumor nec...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of this study was to investigate the effect of interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on NADPH oxidase activity and gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage. The results were compared to the eosoniphilic inducers interleukin-5 (IL-5) and butyric acid. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) or IL-5 (200 pM) caused a significant increase in the expression of the eosinophil peroxidase (EPO) and the major basic protein (MBP) genes. Similar results were observed when the cells were cultured with 0.5 mM butyric acid for 5 days. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) also caused a significant increase in superoxide release by HL-60 clone 15 cells after 2 days compared with control or with butyric acid-induced cells. After 5 days, these cytokines and butyric acid induced an even stronger release of superoxide. HL-60 clone 15 cells cultured with IFN-gamma and TNF-alpha for ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232186"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232186"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232186; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232186]").text(description); $(".js-view-count[data-work-id=12232186]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232186; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232186']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232186, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12232186]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232186,"title":"The effect of IFN-gamma and TNF-alpha on the eosinophilic differentiation and NADPH oxidase activation of human HL-60 clone 15 cells","translated_title":"","metadata":{"abstract":"The aim of this study was to investigate the effect of interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on NADPH oxidase activity and gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage. The results were compared to the eosoniphilic inducers interleukin-5 (IL-5) and butyric acid. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) or IL-5 (200 pM) caused a significant increase in the expression of the eosinophil peroxidase (EPO) and the major basic protein (MBP) genes. Similar results were observed when the cells were cultured with 0.5 mM butyric acid for 5 days. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) also caused a significant increase in superoxide release by HL-60 clone 15 cells after 2 days compared with control or with butyric acid-induced cells. After 5 days, these cytokines and butyric acid induced an even stronger release of superoxide. HL-60 clone 15 cells cultured with IFN-gamma and TNF-alpha for ...","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"Journal of interferon \u0026 cytokine research : the official journal of the International Society for Interferon and Cytokine Research"},"translated_abstract":"The aim of this study was to investigate the effect of interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on NADPH oxidase activity and gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage. The results were compared to the eosoniphilic inducers interleukin-5 (IL-5) and butyric acid. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) or IL-5 (200 pM) caused a significant increase in the expression of the eosinophil peroxidase (EPO) and the major basic protein (MBP) genes. Similar results were observed when the cells were cultured with 0.5 mM butyric acid for 5 days. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) also caused a significant increase in superoxide release by HL-60 clone 15 cells after 2 days compared with control or with butyric acid-induced cells. After 5 days, these cytokines and butyric acid induced an even stronger release of superoxide. HL-60 clone 15 cells cultured with IFN-gamma and TNF-alpha for ...","internal_url":"https://www.academia.edu/12232186/The_effect_of_IFN_gamma_and_TNF_alpha_on_the_eosinophilic_differentiation_and_NADPH_oxidase_activation_of_human_HL_60_clone_15_cells","translated_internal_url":"","created_at":"2015-05-04T13:47:04.233-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":30716972,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_effect_of_IFN_gamma_and_TNF_alpha_on_the_eosinophilic_differentiation_and_NADPH_oxidase_activation_of_human_HL_60_clone_15_cells","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":30716972,"first_name":"JUAN","middle_initials":null,"last_name":"LOPEZ","page_name":"JUANLOPEZ","domain_name":"unearte","created_at":"2015-05-04T06:29:21.113-07:00","display_name":"JUAN LOPEZ","url":"https://unearte.academia.edu/JUANLOPEZ"},"attachments":[],"research_interests":[{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":55175,"name":"Peroxidase","url":"https://www.academia.edu/Documents/in/Peroxidase"},{"id":57802,"name":"Erythropoietin","url":"https://www.academia.edu/Documents/in/Erythropoietin"},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":234980,"name":"NADPH oxidase","url":"https://www.academia.edu/Documents/in/NADPH_oxidase"},{"id":341910,"name":"Butyric Acid","url":"https://www.academia.edu/Documents/in/Butyric_Acid"},{"id":371516,"name":"Eosinophils","url":"https://www.academia.edu/Documents/in/Eosinophils"},{"id":474029,"name":"Tumor necrosis factor-alpha","url":"https://www.academia.edu/Documents/in/Tumor_necrosis_factor-alpha"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers"},{"id":1763968,"name":"Gene Expression Regulation","url":"https://www.academia.edu/Documents/in/Gene_Expression_Regulation"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin"},{"id":2058663,"name":"Interferon gamma","url":"https://www.academia.edu/Documents/in/Interferon_gamma"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232185"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12232185/Proteomic_characterization_of_human_coronary_thrombus_in_patients_with_ST_segment_elevation_acute_myocardial_infarction"><img alt="Research paper thumbnail of Proteomic characterization of human coronary thrombus in patients with ST-segment elevation acute myocardial infarction" class="work-thumbnail" src="https://attachments.academia-assets.com/46291600/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12232185/Proteomic_characterization_of_human_coronary_thrombus_in_patients_with_ST_segment_elevation_acute_myocardial_infarction">Proteomic characterization of human coronary thrombus in patients with ST-segment elevation acute myocardial infarction</a></div><div class="wp-workCard_item"><span>Journal of proteomics</span><span>, Jan 23, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Acute myocardial infarction with ST-segment elevation (STEMI) initiates with intraluminal thrombo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Acute myocardial infarction with ST-segment elevation (STEMI) initiates with intraluminal thrombosis and results in total occlusion of the coronary artery. To date, characterization of the coronary thrombus proteome in STEMI patients has not been yet accomplished. Therefore, we aimed to perform an in-depth proteomic characterization of the human coronary thrombus by means of three different approaches: 2-DE followed by mass spectrometry (MALDI MS/MS), 1-DE combined either with liquid chromatography coupled to mass spectrometry in a MALDI TOF/TOF (LC-MALDI-MS/MS), or in a LTQ-Orbitrap (LC-ESI-MS/MS). This approach allowed us to identify a total of 708 proteins in the thrombus. Expression in coronary thrombi (n=20) of 14 proteins was verified, and the expression of fibrin and 6 cell markers (platelets, monocytes, neutrophils, eosinophils, T-cells and B-cells) quantified by selected reaction monitoring (SRM). A positive correlation of 5 proteins (fermitin homolog 3, thrombospondin-1, m...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1f759ec710e94a7db79829d2318cda3b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46291600,"asset_id":12232185,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46291600/download_file?st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232185"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232185"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232185; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232185]").text(description); $(".js-view-count[data-work-id=12232185]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232185; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232185']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232185, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1f759ec710e94a7db79829d2318cda3b" } } $('.js-work-strip[data-work-id=12232185]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232185,"title":"Proteomic characterization of human coronary thrombus in patients with ST-segment elevation acute myocardial infarction","translated_title":"","metadata":{"abstract":"Acute myocardial infarction with ST-segment elevation (STEMI) initiates with intraluminal thrombosis and results in total occlusion of the coronary artery. To date, characterization of the coronary thrombus proteome in STEMI patients has not been yet accomplished. Therefore, we aimed to perform an in-depth proteomic characterization of the human coronary thrombus by means of three different approaches: 2-DE followed by mass spectrometry (MALDI MS/MS), 1-DE combined either with liquid chromatography coupled to mass spectrometry in a MALDI TOF/TOF (LC-MALDI-MS/MS), or in a LTQ-Orbitrap (LC-ESI-MS/MS). This approach allowed us to identify a total of 708 proteins in the thrombus. Expression in coronary thrombi (n=20) of 14 proteins was verified, and the expression of fibrin and 6 cell markers (platelets, monocytes, neutrophils, eosinophils, T-cells and B-cells) quantified by selected reaction monitoring (SRM). A positive correlation of 5 proteins (fermitin homolog 3, thrombospondin-1, m...","publication_date":{"day":23,"month":1,"year":2014,"errors":{}},"publication_name":"Journal of proteomics"},"translated_abstract":"Acute myocardial infarction with ST-segment elevation (STEMI) initiates with intraluminal thrombosis and results in total occlusion of the coronary artery. To date, characterization of the coronary thrombus proteome in STEMI patients has not been yet accomplished. Therefore, we aimed to perform an in-depth proteomic characterization of the human coronary thrombus by means of three different approaches: 2-DE followed by mass spectrometry (MALDI MS/MS), 1-DE combined either with liquid chromatography coupled to mass spectrometry in a MALDI TOF/TOF (LC-MALDI-MS/MS), or in a LTQ-Orbitrap (LC-ESI-MS/MS). This approach allowed us to identify a total of 708 proteins in the thrombus. Expression in coronary thrombi (n=20) of 14 proteins was verified, and the expression of fibrin and 6 cell markers (platelets, monocytes, neutrophils, eosinophils, T-cells and B-cells) quantified by selected reaction monitoring (SRM). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232184"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12232184/Pharmacological_Profiles_of_Acute_Myeloid_Leukemia_Treatments_in_Patient_Samples_by_Automated_Flow_Cytometry_A_Bridge_to_Individualized_Medicine"><img alt="Research paper thumbnail of Pharmacological Profiles of Acute Myeloid Leukemia Treatments in Patient Samples by Automated Flow Cytometry: A Bridge to Individualized Medicine" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12232184/Pharmacological_Profiles_of_Acute_Myeloid_Leukemia_Treatments_in_Patient_Samples_by_Automated_Flow_Cytometry_A_Bridge_to_Individualized_Medicine">Pharmacological Profiles of Acute Myeloid Leukemia Treatments in Patient Samples by Automated Flow Cytometry: A Bridge to Individualized Medicine</a></div><div class="wp-workCard_item"><span>Clinical Lymphoma Myeloma and Leukemia</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We have evaluated the ex vivo pharmacology of single drugs and drug combinations in malignant cel...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We have evaluated the ex vivo pharmacology of single drugs and drug combinations in malignant cells of bone marrow samples from 125 patients with acute myeloid leukemia using a novel automated flow cytometry-based platform (ExviTech). We have improved previous ex vivo drug testing with 4 innovations: identifying individual leukemic cells, using intact whole blood during the incubation, using an automated platform that escalates reliably data, and performing analyses pharmacodynamic population models. Samples were sent from 24 hospitals to a central laboratory and incubated for 48 hours in whole blood, after which drug activity was measured in terms of depletion of leukemic cells. The sensitivity of single drugs is assessed for standard efficacy (EMAX) and potency (EC50) variables, ranked as percentiles within the population. The sensitivity of drug-combination treatments is assessed for the synergism achieved in each patient sample. We found a large variability among patient samples in the dose-response curves to a single drug or combination treatment. We hypothesize that the use of the individual patient ex vivo pharmacological profiles may help to guide a personalized treatment selection.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232184"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232184"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232184; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232184]").text(description); $(".js-view-count[data-work-id=12232184]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232184; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232184']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232184, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12232184]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232184,"title":"Pharmacological Profiles of Acute Myeloid Leukemia Treatments in Patient Samples by Automated Flow Cytometry: A Bridge to Individualized Medicine","translated_title":"","metadata":{"abstract":"We have evaluated the ex vivo pharmacology of single drugs and drug combinations in malignant cells of bone marrow samples from 125 patients with acute myeloid leukemia using a novel automated flow cytometry-based platform (ExviTech). We have improved previous ex vivo drug testing with 4 innovations: identifying individual leukemic cells, using intact whole blood during the incubation, using an automated platform that escalates reliably data, and performing analyses pharmacodynamic population models. Samples were sent from 24 hospitals to a central laboratory and incubated for 48 hours in whole blood, after which drug activity was measured in terms of depletion of leukemic cells. The sensitivity of single drugs is assessed for standard efficacy (EMAX) and potency (EC50) variables, ranked as percentiles within the population. The sensitivity of drug-combination treatments is assessed for the synergism achieved in each patient sample. We found a large variability among patient samples in the dose-response curves to a single drug or combination treatment. We hypothesize that the use of the individual patient ex vivo pharmacological profiles may help to guide a personalized treatment selection.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Clinical Lymphoma Myeloma and Leukemia"},"translated_abstract":"We have evaluated the ex vivo pharmacology of single drugs and drug combinations in malignant cells of bone marrow samples from 125 patients with acute myeloid leukemia using a novel automated flow cytometry-based platform (ExviTech). We have improved previous ex vivo drug testing with 4 innovations: identifying individual leukemic cells, using intact whole blood during the incubation, using an automated platform that escalates reliably data, and performing analyses pharmacodynamic population models. Samples were sent from 24 hospitals to a central laboratory and incubated for 48 hours in whole blood, after which drug activity was measured in terms of depletion of leukemic cells. The sensitivity of single drugs is assessed for standard efficacy (EMAX) and potency (EC50) variables, ranked as percentiles within the population. The sensitivity of drug-combination treatments is assessed for the synergism achieved in each patient sample. We found a large variability among patient samples in the dose-response curves to a single drug or combination treatment. We hypothesize that the use of the individual patient ex vivo pharmacological profiles may help to guide a personalized treatment selection.","internal_url":"https://www.academia.edu/12232184/Pharmacological_Profiles_of_Acute_Myeloid_Leukemia_Treatments_in_Patient_Samples_by_Automated_Flow_Cytometry_A_Bridge_to_Individualized_Medicine","translated_internal_url":"","created_at":"2015-05-04T13:47:03.986-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":30716972,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Pharmacological_Profiles_of_Acute_Myeloid_Leukemia_Treatments_in_Patient_Samples_by_Automated_Flow_Cytometry_A_Bridge_to_Individualized_Medicine","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":30716972,"first_name":"JUAN","middle_initials":null,"last_name":"LOPEZ","page_name":"JUANLOPEZ","domain_name":"unearte","created_at":"2015-05-04T06:29:21.113-07:00","display_name":"JUAN LOPEZ","url":"https://unearte.academia.edu/JUANLOPEZ"},"attachments":[],"research_interests":[{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry"},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome"},{"id":58380,"name":"Therapeutic drug monitoring","url":"https://www.academia.edu/Documents/in/Therapeutic_drug_monitoring"},{"id":59057,"name":"Acute Myeloid Leukemia","url":"https://www.academia.edu/Documents/in/Acute_Myeloid_Leukemia"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":820718,"name":"Individualized Medicine","url":"https://www.academia.edu/Documents/in/Individualized_Medicine"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"},{"id":1212103,"name":"Antineoplastic Agents","url":"https://www.academia.edu/Documents/in/Antineoplastic_Agents"},{"id":1664707,"name":"Bone Marrow Cells","url":"https://www.academia.edu/Documents/in/Bone_Marrow_Cells"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232183"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12232183/The_millimeter_wave_spectrum_of_cyclopentene"><img alt="Research paper thumbnail of The millimeter-wave spectrum of cyclopentene" class="work-thumbnail" src="https://attachments.academia-assets.com/46291432/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12232183/The_millimeter_wave_spectrum_of_cyclopentene">The millimeter-wave spectrum of cyclopentene</a></div><div class="wp-workCard_item"><span>Journal of Molecular Spectroscopy - J MOL SPECTROSC</span><span>, 1992</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e85e4871f1a161c966cc0a9a14ff848b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46291432,"asset_id":12232183,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46291432/download_file?st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232183"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232183"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232183; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232183]").text(description); $(".js-view-count[data-work-id=12232183]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232183; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232183']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232183, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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A two-state analysis of the vibration-rotation interaction for the u = 0 and D = 1 states gives an energy separation between these states of 0.91173 l(6) cm-'. The ring-puckering vibrational dependence of the rotational constants has been analyzed in terms of a reduced vibrational Hamiltonian with kinetic energy terms including the ring-puckering dependence of the reduced mass. The vibrational dependence of the quartic centrifugal distortion constants, including a small dependence of A, and b, has been aCCOUnted for. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232182"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12232182/Expression_of_the_adrenomedullin_binding_protein_complement_factor_H_in_the_pancreas_and_its_physiological_impact_on_insulin_secretion"><img alt="Research paper thumbnail of Expression of the adrenomedullin binding protein, complement factor H, in the pancreas and its physiological impact on insulin secretion" class="work-thumbnail" src="https://attachments.academia-assets.com/46291426/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12232182/Expression_of_the_adrenomedullin_binding_protein_complement_factor_H_in_the_pancreas_and_its_physiological_impact_on_insulin_secretion">Expression of the adrenomedullin binding protein, complement factor H, in the pancreas and its physiological impact on insulin secretion</a></div><div class="wp-workCard_item"><span>Journal of Endocrinology - J ENDOCRINOL</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Adrenomedullin (AM) is a ubiquitous peptide hormone which, among other functional roles, reduces ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Adrenomedullin (AM) is a ubiquitous peptide hormone which, among other functional roles, reduces insulin secretion in the pancreas. Recently we have described the interaction between AM and the complement regulator protein factor H, which results in mutual modulation of their respective functions. Here we identify the expression of factor H in the cells of the rat pancreatic islets by immunohistochemistry and multiple immunofluorescence followed by confocal microscopy. In addition, double immunogold staining under the electron microscope showed coexistence of insulin and factor H immuno- reactivities within the same secretory granules; interest- ingly, factor H staining was found in the electron-lucent haloes whereas the insulin antibody labeled preferentially the dense cores. The existence of factor H mRNA in the pancreas was confirmed by RT-PCR and in situ hybrid- ization. The function of factor H in the pancreas was investigated with an insulin secretion assay. Addition of factor...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="aa9f64c1013ee3a0c2e89f8cae404850" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46291426,"asset_id":12232182,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46291426/download_file?st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232182"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232182"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232182; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232182]").text(description); $(".js-view-count[data-work-id=12232182]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232182; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232182']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232182, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "aa9f64c1013ee3a0c2e89f8cae404850" } } $('.js-work-strip[data-work-id=12232182]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232182,"title":"Expression of the adrenomedullin binding protein, complement factor H, in the pancreas and its physiological impact on insulin secretion","translated_title":"","metadata":{"abstract":"Adrenomedullin (AM) is a ubiquitous peptide hormone which, among other functional roles, reduces insulin secretion in the pancreas. Recently we have described the interaction between AM and the complement regulator protein factor H, which results in mutual modulation of their respective functions. Here we identify the expression of factor H in the cells of the rat pancreatic islets by immunohistochemistry and multiple immunofluorescence followed by confocal microscopy. In addition, double immunogold staining under the electron microscope showed coexistence of insulin and factor H immuno- reactivities within the same secretory granules; interest- ingly, factor H staining was found in the electron-lucent haloes whereas the insulin antibody labeled preferentially the dense cores. The existence of factor H mRNA in the pancreas was confirmed by RT-PCR and in situ hybrid- ization. The function of factor H in the pancreas was investigated with an insulin secretion assay. Addition of factor...","publication_date":{"day":null,"month":null,"year":2001,"errors":{}},"publication_name":"Journal of Endocrinology - J ENDOCRINOL"},"translated_abstract":"Adrenomedullin (AM) is a ubiquitous peptide hormone which, among other functional roles, reduces insulin secretion in the pancreas. Recently we have described the interaction between AM and the complement regulator protein factor H, which results in mutual modulation of their respective functions. Here we identify the expression of factor H in the cells of the rat pancreatic islets by immunohistochemistry and multiple immunofluorescence followed by confocal microscopy. In addition, double immunogold staining under the electron microscope showed coexistence of insulin and factor H immuno- reactivities within the same secretory granules; interest- ingly, factor H staining was found in the electron-lucent haloes whereas the insulin antibody labeled preferentially the dense cores. 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A novel lignan type from juniperus thurifera l" class="work-thumbnail" src="https://attachments.academia-assets.com/46291429/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12232181/Thuriferic_acid_A_novel_lignan_type_from_juniperus_thurifera_l">Thuriferic acid. A novel lignan type from juniperus thurifera l</a></div><div class="wp-workCard_item"><span>Tetrahedron</span><span>, 1988</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1f5053f454aa9662449a058e95552810" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46291429,"asset_id":12232181,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46291429/download_file?st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232181"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232181"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232181; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232181]").text(description); $(".js-view-count[data-work-id=12232181]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232181; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232181']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232181, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1f5053f454aa9662449a058e95552810" } } $('.js-work-strip[data-work-id=12232181]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232181,"title":"Thuriferic acid. 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Las técnicas de depuración extrarrenal continuas deberían considerarse como tratamiento precoz en los casos en que haya esta asociación.","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"grobid_abstract_attachment_id":46291447},"translated_abstract":null,"internal_url":"https://www.academia.edu/12232180/Acidosis_l%C3%A1ctica_y_metformina_Tratamiento_combinado_con_hemodi%C3%A1lisis_y_hemofiltraci%C3%B3n","translated_internal_url":"","created_at":"2015-05-04T13:47:03.170-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":30716972,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":46291447,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/46291447/thumbnails/1.jpg","file_name":"Acidosis_lctica_y_metformina._Tratamient20160606-2677-j0x6ym.pdf","download_url":"https://www.academia.edu/attachments/46291447/download_file?st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Acidosis_lactica_y_metformina_Tratamient.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/46291447/Acidosis_lctica_y_metformina._Tratamient20160606-2677-j0x6ym-libre.pdf?1465252051=\u0026response-content-disposition=attachment%3B+filename%3DAcidosis_lactica_y_metformina_Tratamient.pdf\u0026Expires=1732408219\u0026Signature=RvpktKP5xU4XXer4qhKkeJj-byZD62ho2gVFM5OXkFNSKmmOupbR7Z2cdiMU9PKOdgvsk8QveSrtiD9DFM4io4BY4AQnrQaHhk~E~Z1JshEJnvlYgzRSbk6BsCxsrnK9HKmFD317eeT3-zTMr76hmtqX-jEj88-~7QkFDF0C-p0LTTE-a0LebjJDOfqtuBrxymTAUN05AHbk2AtwKNwdBgpCnI5hke5W-AeZlU7zBgsfpRINu~UsmunOPMdJ9H~mbsg06SMet3AOFQtcJJa2P3JNKrgELjXdzJ~QwXgz3S7F6v-27sf-QRAJwWKJxdEYRUgc49z-xR~1NMYnv8uKqg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Acidosis_láctica_y_metformina_Tratamiento_combinado_con_hemodiálisis_y_hemofiltración","translated_slug":"","page_count":4,"language":"es","content_type":"Work","owner":{"id":30716972,"first_name":"JUAN","middle_initials":null,"last_name":"LOPEZ","page_name":"JUANLOPEZ","domain_name":"unearte","created_at":"2015-05-04T06:29:21.113-07:00","display_name":"JUAN LOPEZ","url":"https://unearte.academia.edu/JUANLOPEZ"},"attachments":[{"id":46291447,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/46291447/thumbnails/1.jpg","file_name":"Acidosis_lctica_y_metformina._Tratamient20160606-2677-j0x6ym.pdf","download_url":"https://www.academia.edu/attachments/46291447/download_file?st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Acidosis_lactica_y_metformina_Tratamient.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/46291447/Acidosis_lctica_y_metformina._Tratamient20160606-2677-j0x6ym-libre.pdf?1465252051=\u0026response-content-disposition=attachment%3B+filename%3DAcidosis_lactica_y_metformina_Tratamient.pdf\u0026Expires=1732408219\u0026Signature=RvpktKP5xU4XXer4qhKkeJj-byZD62ho2gVFM5OXkFNSKmmOupbR7Z2cdiMU9PKOdgvsk8QveSrtiD9DFM4io4BY4AQnrQaHhk~E~Z1JshEJnvlYgzRSbk6BsCxsrnK9HKmFD317eeT3-zTMr76hmtqX-jEj88-~7QkFDF0C-p0LTTE-a0LebjJDOfqtuBrxymTAUN05AHbk2AtwKNwdBgpCnI5hke5W-AeZlU7zBgsfpRINu~UsmunOPMdJ9H~mbsg06SMet3AOFQtcJJa2P3JNKrgELjXdzJ~QwXgz3S7F6v-27sf-QRAJwWKJxdEYRUgc49z-xR~1NMYnv8uKqg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":101212,"name":"Hemodialysis","url":"https://www.academia.edu/Documents/in/Hemodialysis"}],"urls":[{"id":4738436,"url":"http://www.sciencedirect.com/science/article/pii/S1575092207714936"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232179"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12232179/Microwave_spectra_and_internal_rotation_in_%CE%B1_angelicalactone"><img alt="Research paper thumbnail of Microwave spectra and internal rotation in α-angelicalactone" class="work-thumbnail" src="https://attachments.academia-assets.com/46291430/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12232179/Microwave_spectra_and_internal_rotation_in_%CE%B1_angelicalactone">Microwave spectra and internal rotation in α-angelicalactone</a></div><div class="wp-workCard_item"><span>Journal of Molecular Spectroscopy</span><span>, 1987</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="78ad5493dcc5efe718991c769a4343d6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46291430,"asset_id":12232179,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46291430/download_file?st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232179"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232179"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232179; 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The internal rotation barrier of the methyl group has been determined in the ground and four vibrationally excited states from the A-E splittings. The results indicate a possible interaction between the methyl torsion and the ring puckering mode. The ground state rotational parameters are consistent with a planar ring skeleton. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232177"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/12232177/cDNA_AFLP_analysis_of_differential_gene_expression_during_the_interaction_between_sugarcane_and_Puccinia_melanocephala"><img alt="Research paper thumbnail of cDNA-AFLP analysis of differential gene expression during the interaction between sugarcane and Puccinia melanocephala" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/12232177/cDNA_AFLP_analysis_of_differential_gene_expression_during_the_interaction_between_sugarcane_and_Puccinia_melanocephala">cDNA-AFLP analysis of differential gene expression during the interaction between sugarcane and Puccinia melanocephala</a></div><div class="wp-workCard_item"><span>Plant Breeding</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232177"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232177"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232177; 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The enviomment is for an embedded processor used for audio decompression algorithms including: MPEG2, Dolby AC-3 Sumd and Dolby Pro-logic. The enabling component of the jmware environment is a retargetable compiler which maps high-level algorithm onto the embedded processox Although compilation is the critical technoba, this eqerience has shown that it is imujicient and that other supporting design tools are also importam. For this project, that environment includes an instruction-set simulator; a sowe-bel debugger; a custom linkel; and a compiler validation strategy The methodologies are ourlined in this paper with an emphasis on the lessons learned in this hardware-somare team devebpmt.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="48144fb13c753fff66160b0ddd65f092" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46291451,"asset_id":12232176,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46291451/download_file?st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232176"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232176"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232176; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232176]").text(description); $(".js-view-count[data-work-id=12232176]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232176; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232176']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232176, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "48144fb13c753fff66160b0ddd65f092" } } $('.js-work-strip[data-work-id=12232176]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232176,"title":"An Embedded System Case Study: The Firm Ware Development Environment For A Multimedia Audio Processor","translated_title":"","metadata":{"abstract":"Ris paper outlines a case study at SGS-Thomson Mkroelec-honks on the development of a frmware development environment in cooperation with ”son Consumer Electmnics Componknts. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232173"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/12232173/Analysis_of_genomic_variability_in_transgenic_sugarcane_plants_produced_by_Agrobacterium_tumefaciens_infection"><img alt="Research paper thumbnail of Analysis of genomic variability in transgenic sugarcane plants produced by Agrobacterium tumefaciens infection" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/12232173/Analysis_of_genomic_variability_in_transgenic_sugarcane_plants_produced_by_Agrobacterium_tumefaciens_infection">Analysis of genomic variability in transgenic sugarcane plants produced by Agrobacterium tumefaciens infection</a></div><div class="wp-workCard_item"><span>Plant …</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... Arencibia, A., E. Carmona, MT Cornide, S. Castiglione, J. O&#x27;Relly, A. Chinea, P. Oramas,...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... Arencibia, A., E. Carmona, MT Cornide, S. Castiglione, J. O&#x27;Relly, A. Chinea, P. Oramas, and F. Sala, 1999: Somaclonal variation in ... Heinz, DJ, and GW Mee, 1970: Morphologic cytogenetic and enzymatic variation in Saccharum species hybrid clones derived from callus tissue. ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232173"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232173"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232173; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232173]").text(description); $(".js-view-count[data-work-id=12232173]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232173; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232173']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232173, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12232173]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232173,"title":"Analysis of genomic variability in transgenic sugarcane plants produced by Agrobacterium tumefaciens infection","translated_title":"","metadata":{"abstract":"... 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Heinz, DJ, and GW Mee, 1970: Morphologic cytogenetic and enzymatic variation in Saccharum species hybrid clones derived from callus tissue. ...","internal_url":"https://www.academia.edu/12232173/Analysis_of_genomic_variability_in_transgenic_sugarcane_plants_produced_by_Agrobacterium_tumefaciens_infection","translated_internal_url":"","created_at":"2015-05-04T13:47:01.478-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":30716972,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Analysis_of_genomic_variability_in_transgenic_sugarcane_plants_produced_by_Agrobacterium_tumefaciens_infection","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":30716972,"first_name":"JUAN","middle_initials":null,"last_name":"LOPEZ","page_name":"JUANLOPEZ","domain_name":"unearte","created_at":"2015-05-04T06:29:21.113-07:00","display_name":"JUAN LOPEZ","url":"https://unearte.academia.edu/JUANLOPEZ"},"attachments":[],"research_interests":[{"id":5541,"name":"Plant Biology","url":"https://www.academia.edu/Documents/in/Plant_Biology"},{"id":14933,"name":"Plant Breeding","url":"https://www.academia.edu/Documents/in/Plant_Breeding"},{"id":106562,"name":"Plant","url":"https://www.academia.edu/Documents/in/Plant"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232172"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12232172/The_effect_of_IFN_%CE%B3_and_TNF_%CE%B1_on_the_eosinophilic_differentiation_and_NADPH_oxidase_activation_of_human_HL_60_clone_15_cells"><img alt="Research paper thumbnail of The effect of IFN-γ and TNF-α on the eosinophilic differentiation and NADPH oxidase activation of human HL-60 clone 15 cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12232172/The_effect_of_IFN_%CE%B3_and_TNF_%CE%B1_on_the_eosinophilic_differentiation_and_NADPH_oxidase_activation_of_human_HL_60_clone_15_cells">The effect of IFN-γ and TNF-α on the eosinophilic differentiation and NADPH oxidase activation of human HL-60 clone 15 cells</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of this study was to investigate the effect of interferon-gamma (IFN-gamma) and tumor nec...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of this study was to investigate the effect of interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on NADPH oxidase activity and gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage. The results were compared to the eosoniphilic inducers interleukin-5 (IL-5) and butyric acid. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) or IL-5 (200 pM) caused a significant increase in the expression of the eosinophil peroxidase (EPO) and the major basic protein (MBP) genes. Similar results were observed when the cells were cultured with 0.5 mM butyric acid for 5 days. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) also caused a significant increase in superoxide release by HL-60 clone 15 cells after 2 days compared with control or with butyric acid-induced cells. After 5 days, these cytokines and butyric acid induced an even stronger release of superoxide. HL-60 clone 15 cells cultured with IFN-gamma and TNF-alpha for 2 days showed a significant increase in gp91-phox gene expression. We conclude that IFN-gamma and TNF-alpha are sufficient to induce the differentiation of HL-60 clone 15 cells to the eosinophilic lineage and to upregulate gp91-phox gene expression and activity of the NADPH oxidase system.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232172"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232172"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232172; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232172]").text(description); $(".js-view-count[data-work-id=12232172]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232172; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232172']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232172, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12232172]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232172,"title":"The effect of IFN-γ and TNF-α on the eosinophilic differentiation and NADPH oxidase activation of human HL-60 clone 15 cells","translated_title":"","metadata":{"abstract":"The aim of this study was to investigate the effect of interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on NADPH oxidase activity and gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage. The results were compared to the eosoniphilic inducers interleukin-5 (IL-5) and butyric acid. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) or IL-5 (200 pM) caused a significant increase in the expression of the eosinophil peroxidase (EPO) and the major basic protein (MBP) genes. Similar results were observed when the cells were cultured with 0.5 mM butyric acid for 5 days. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) also caused a significant increase in superoxide release by HL-60 clone 15 cells after 2 days compared with control or with butyric acid-induced cells. After 5 days, these cytokines and butyric acid induced an even stronger release of superoxide. HL-60 clone 15 cells cultured with IFN-gamma and TNF-alpha for 2 days showed a significant increase in gp91-phox gene expression. We conclude that IFN-gamma and TNF-alpha are sufficient to induce the differentiation of HL-60 clone 15 cells to the eosinophilic lineage and to upregulate gp91-phox gene expression and activity of the NADPH oxidase system.","publication_date":{"day":null,"month":null,"year":2003,"errors":{}}},"translated_abstract":"The aim of this study was to investigate the effect of interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on NADPH oxidase activity and gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage. The results were compared to the eosoniphilic inducers interleukin-5 (IL-5) and butyric acid. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) or IL-5 (200 pM) caused a significant increase in the expression of the eosinophil peroxidase (EPO) and the major basic protein (MBP) genes. Similar results were observed when the cells were cultured with 0.5 mM butyric acid for 5 days. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) also caused a significant increase in superoxide release by HL-60 clone 15 cells after 2 days compared with control or with butyric acid-induced cells. After 5 days, these cytokines and butyric acid induced an even stronger release of superoxide. HL-60 clone 15 cells cultured with IFN-gamma and TNF-alpha for 2 days showed a significant increase in gp91-phox gene expression. We conclude that IFN-gamma and TNF-alpha are sufficient to induce the differentiation of HL-60 clone 15 cells to the eosinophilic lineage and to upregulate gp91-phox gene expression and activity of the NADPH oxidase system.","internal_url":"https://www.academia.edu/12232172/The_effect_of_IFN_%CE%B3_and_TNF_%CE%B1_on_the_eosinophilic_differentiation_and_NADPH_oxidase_activation_of_human_HL_60_clone_15_cells","translated_internal_url":"","created_at":"2015-05-04T13:47:01.386-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":30716972,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_effect_of_IFN_γ_and_TNF_α_on_the_eosinophilic_differentiation_and_NADPH_oxidase_activation_of_human_HL_60_clone_15_cells","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":30716972,"first_name":"JUAN","middle_initials":null,"last_name":"LOPEZ","page_name":"JUANLOPEZ","domain_name":"unearte","created_at":"2015-05-04T06:29:21.113-07:00","display_name":"JUAN LOPEZ","url":"https://unearte.academia.edu/JUANLOPEZ"},"attachments":[],"research_interests":[{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":55175,"name":"Peroxidase","url":"https://www.academia.edu/Documents/in/Peroxidase"},{"id":57802,"name":"Erythropoietin","url":"https://www.academia.edu/Documents/in/Erythropoietin"},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":234980,"name":"NADPH oxidase","url":"https://www.academia.edu/Documents/in/NADPH_oxidase"},{"id":341910,"name":"Butyric Acid","url":"https://www.academia.edu/Documents/in/Butyric_Acid"},{"id":371516,"name":"Eosinophils","url":"https://www.academia.edu/Documents/in/Eosinophils"},{"id":474029,"name":"Tumor necrosis factor-alpha","url":"https://www.academia.edu/Documents/in/Tumor_necrosis_factor-alpha"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers"},{"id":1763968,"name":"Gene Expression Regulation","url":"https://www.academia.edu/Documents/in/Gene_Expression_Regulation"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin"},{"id":2058663,"name":"Interferon gamma","url":"https://www.academia.edu/Documents/in/Interferon_gamma"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232171"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/12232171/Spatial_learning_in_turtles"><img alt="Research paper thumbnail of Spatial learning in turtles" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/12232171/Spatial_learning_in_turtles">Spatial learning in turtles</a></div><div class="wp-workCard_item"><span>Animal Cognition</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... JC López (✉) · Y. Gómez · F. Rodríguez · C. Broglio · JP Vargas · C. Salas Laboratorio de Psi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... JC López (✉) · Y. Gómez · F. Rodríguez · C. Broglio · JP Vargas · C. Salas Laboratorio de Psicobiología, Universidad de Sevilla, Avda ... appear to be a monophyletic group that evolved from a single stock of primitive tetrapods during the early Carboniferous (Carroll 1988; Caspers ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232171"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232171"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232171; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232171]").text(description); $(".js-view-count[data-work-id=12232171]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232171; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232171']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232171, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12232171]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232171,"title":"Spatial learning in turtles","translated_title":"","metadata":{"abstract":"... JC López (✉) · Y. Gómez · F. Rodríguez · C. Broglio · JP Vargas · C. Salas Laboratorio de Psicobiología, Universidad de Sevilla, Avda ... appear to be a monophyletic group that evolved from a single stock of primitive tetrapods during the early Carboniferous (Carroll 1988; Caspers ...","publication_date":{"day":null,"month":null,"year":2001,"errors":{}},"publication_name":"Animal Cognition"},"translated_abstract":"... JC López (✉) · Y. Gómez · F. Rodríguez · C. Broglio · JP Vargas · C. Salas Laboratorio de Psicobiología, Universidad de Sevilla, Avda ... appear to be a monophyletic group that evolved from a single stock of primitive tetrapods during the early Carboniferous (Carroll 1988; Caspers ...","internal_url":"https://www.academia.edu/12232171/Spatial_learning_in_turtles","translated_internal_url":"","created_at":"2015-05-04T13:47:01.262-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":30716972,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Spatial_learning_in_turtles","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":30716972,"first_name":"JUAN","middle_initials":null,"last_name":"LOPEZ","page_name":"JUANLOPEZ","domain_name":"unearte","created_at":"2015-05-04T06:29:21.113-07:00","display_name":"JUAN LOPEZ","url":"https://unearte.academia.edu/JUANLOPEZ"},"attachments":[],"research_interests":[{"id":11347,"name":"Animal Cognition","url":"https://www.academia.edu/Documents/in/Animal_Cognition"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":121707,"name":"Open Field","url":"https://www.academia.edu/Documents/in/Open_Field"},{"id":192347,"name":"Spatial Learning","url":"https://www.academia.edu/Documents/in/Spatial_Learning"},{"id":584723,"name":"Frame of reference","url":"https://www.academia.edu/Documents/in/Frame_of_reference"},{"id":987444,"name":"Spatial Relationships","url":"https://www.academia.edu/Documents/in/Spatial_Relationships"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="2909739" id="papers"><div class="js-work-strip profile--work_container" data-work-id="12232190"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12232190/Systems_Biology_of_Tissue_Specific_Response_to_Anaplasma_phagocytophilum_Reveals_Differentiated_Apoptosis_in_the_Tick_Vector_Ixodes_scapularis"><img alt="Research paper thumbnail of Systems Biology of Tissue-Specific Response to Anaplasma phagocytophilum Reveals Differentiated Apoptosis in the Tick Vector Ixodes scapularis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12232190/Systems_Biology_of_Tissue_Specific_Response_to_Anaplasma_phagocytophilum_Reveals_Differentiated_Apoptosis_in_the_Tick_Vector_Ixodes_scapularis">Systems Biology of Tissue-Specific Response to Anaplasma phagocytophilum Reveals Differentiated Apoptosis in the Tick Vector Ixodes scapularis</a></div><div class="wp-workCard_item"><span>PLOS Genetics</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Anaplasma phagocytophilum is an emerging pathogen that causes human granulocytic anaplasmosis. In...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Anaplasma phagocytophilum is an emerging pathogen that causes human granulocytic anaplasmosis. Infection with this zoonotic pathogen affects cell function in both vertebrate host and the tick vector, Ixodes scapularis. Global tissue-specific response and apoptosis signaling pathways were characterized in I. scapularis nymphs and adult female midguts and salivary glands infected with A. phagocytophilum using a systems biology approach combining transcriptomics and proteomics. Apoptosis was selected for pathway-focused analysis due to its role in bacterial infection of tick cells. The results showed tissue-specific differences in tick response to infection and revealed differentiated regulation of apoptosis pathways. The impact of bacterial infection was more pronounced in tick nymphs and midguts than in salivary glands, probably reflecting bacterial developmental cycle. All apoptosis pathways described in other organisms were identified in I. scapularis, except for the absence of the Perforin ortholog. Functional characterization using RNA interference showed that Porin knockdown significantly increases tick colonization by A. phagocytophilum. Infection with A. phagocytophilum produced complex tissue-specific alterations in transcript and protein levels. In tick nymphs, the results suggested a possible effect of bacterial infection on the inhibition of tick immune response. In tick midguts, the results suggested that A. phagocytophilum infection inhibited cell apoptosis to facilitate and establish infection through up-regulation of the JAK/STAT pathway. Bacterial infection inhibited the intrinsic apoptosis pathway in tick salivary glands by down-regulating Porin expression that resulted in the inhibition of Cytochrome c release as the anti-apoptotic mechanism to facilitate bacterial infection. However, tick salivary glands may promote apoptosis to limit bacterial infection through induction of the extrinsic apoptosis pathway. These dynamic changes in response to A. phagocytophilum in I. scapularis tissue-specific transcriptome and proteome demonstrated the complexity of the tick response to infection and will contribute to characterize gene regulation in ticks.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232190"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232190"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232190; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232190]").text(description); $(".js-view-count[data-work-id=12232190]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232190; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232190']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232190, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12232190]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232190,"title":"Systems Biology of Tissue-Specific Response to Anaplasma phagocytophilum Reveals Differentiated Apoptosis in the Tick Vector Ixodes scapularis","translated_title":"","metadata":{"abstract":"Anaplasma phagocytophilum is an emerging pathogen that causes human granulocytic anaplasmosis. Infection with this zoonotic pathogen affects cell function in both vertebrate host and the tick vector, Ixodes scapularis. Global tissue-specific response and apoptosis signaling pathways were characterized in I. scapularis nymphs and adult female midguts and salivary glands infected with A. phagocytophilum using a systems biology approach combining transcriptomics and proteomics. Apoptosis was selected for pathway-focused analysis due to its role in bacterial infection of tick cells. The results showed tissue-specific differences in tick response to infection and revealed differentiated regulation of apoptosis pathways. The impact of bacterial infection was more pronounced in tick nymphs and midguts than in salivary glands, probably reflecting bacterial developmental cycle. All apoptosis pathways described in other organisms were identified in I. scapularis, except for the absence of the Perforin ortholog. Functional characterization using RNA interference showed that Porin knockdown significantly increases tick colonization by A. phagocytophilum. Infection with A. phagocytophilum produced complex tissue-specific alterations in transcript and protein levels. In tick nymphs, the results suggested a possible effect of bacterial infection on the inhibition of tick immune response. In tick midguts, the results suggested that A. phagocytophilum infection inhibited cell apoptosis to facilitate and establish infection through up-regulation of the JAK/STAT pathway. Bacterial infection inhibited the intrinsic apoptosis pathway in tick salivary glands by down-regulating Porin expression that resulted in the inhibition of Cytochrome c release as the anti-apoptotic mechanism to facilitate bacterial infection. However, tick salivary glands may promote apoptosis to limit bacterial infection through induction of the extrinsic apoptosis pathway. These dynamic changes in response to A. phagocytophilum in I. scapularis tissue-specific transcriptome and proteome demonstrated the complexity of the tick response to infection and will contribute to characterize gene regulation in ticks.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"PLOS Genetics"},"translated_abstract":"Anaplasma phagocytophilum is an emerging pathogen that causes human granulocytic anaplasmosis. Infection with this zoonotic pathogen affects cell function in both vertebrate host and the tick vector, Ixodes scapularis. Global tissue-specific response and apoptosis signaling pathways were characterized in I. scapularis nymphs and adult female midguts and salivary glands infected with A. phagocytophilum using a systems biology approach combining transcriptomics and proteomics. Apoptosis was selected for pathway-focused analysis due to its role in bacterial infection of tick cells. The results showed tissue-specific differences in tick response to infection and revealed differentiated regulation of apoptosis pathways. The impact of bacterial infection was more pronounced in tick nymphs and midguts than in salivary glands, probably reflecting bacterial developmental cycle. All apoptosis pathways described in other organisms were identified in I. scapularis, except for the absence of the Perforin ortholog. Functional characterization using RNA interference showed that Porin knockdown significantly increases tick colonization by A. phagocytophilum. Infection with A. phagocytophilum produced complex tissue-specific alterations in transcript and protein levels. In tick nymphs, the results suggested a possible effect of bacterial infection on the inhibition of tick immune response. In tick midguts, the results suggested that A. phagocytophilum infection inhibited cell apoptosis to facilitate and establish infection through up-regulation of the JAK/STAT pathway. Bacterial infection inhibited the intrinsic apoptosis pathway in tick salivary glands by down-regulating Porin expression that resulted in the inhibition of Cytochrome c release as the anti-apoptotic mechanism to facilitate bacterial infection. However, tick salivary glands may promote apoptosis to limit bacterial infection through induction of the extrinsic apoptosis pathway. These dynamic changes in response to A. phagocytophilum in I. scapularis tissue-specific transcriptome and proteome demonstrated the complexity of the tick response to infection and will contribute to characterize gene regulation in ticks.","internal_url":"https://www.academia.edu/12232190/Systems_Biology_of_Tissue_Specific_Response_to_Anaplasma_phagocytophilum_Reveals_Differentiated_Apoptosis_in_the_Tick_Vector_Ixodes_scapularis","translated_internal_url":"","created_at":"2015-05-04T13:47:04.805-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":30716972,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Systems_Biology_of_Tissue_Specific_Response_to_Anaplasma_phagocytophilum_Reveals_Differentiated_Apoptosis_in_the_Tick_Vector_Ixodes_scapularis","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":30716972,"first_name":"JUAN","middle_initials":null,"last_name":"LOPEZ","page_name":"JUANLOPEZ","domain_name":"unearte","created_at":"2015-05-04T06:29:21.113-07:00","display_name":"JUAN LOPEZ","url":"https://unearte.academia.edu/JUANLOPEZ"},"attachments":[],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":5400,"name":"Systems Biology","url":"https://www.academia.edu/Documents/in/Systems_Biology"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis"},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction"},{"id":43761,"name":"Transcriptome","url":"https://www.academia.edu/Documents/in/Transcriptome"},{"id":51121,"name":"RNA interference","url":"https://www.academia.edu/Documents/in/RNA_interference"},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals"},{"id":521909,"name":"Anaplasmosis","url":"https://www.academia.edu/Documents/in/Anaplasmosis"},{"id":558653,"name":"PLoS Genetics","url":"https://www.academia.edu/Documents/in/PLoS_Genetics"},{"id":1400784,"name":"Anaplasma Phagocytophilum","url":"https://www.academia.edu/Documents/in/Anaplasma_Phagocytophilum"},{"id":1763968,"name":"Gene Expression Regulation","url":"https://www.academia.edu/Documents/in/Gene_Expression_Regulation"},{"id":1901293,"name":"Salivary Glands","url":"https://www.academia.edu/Documents/in/Salivary_Glands"},{"id":2002363,"name":"Insect Vectors","url":"https://www.academia.edu/Documents/in/Insect_Vectors"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232189"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/12232189/VARIACI%C3%93N_DE_LAS_TENSIONES_DE_CRECIMIENTO_EN_TRES_CLONES_DE_Eucalyptus_grandis_SEG%C3%9AN_EL_ESTADO_DE_COMPETENCIA_INDIVIDUAL"><img alt="Research paper thumbnail of VARIACIÓN DE LAS TENSIONES DE CRECIMIENTO EN TRES CLONES DE Eucalyptus grandis SEGÚN EL ESTADO DE COMPETENCIA INDIVIDUAL" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/12232189/VARIACI%C3%93N_DE_LAS_TENSIONES_DE_CRECIMIENTO_EN_TRES_CLONES_DE_Eucalyptus_grandis_SEG%C3%9AN_EL_ESTADO_DE_COMPETENCIA_INDIVIDUAL">VARIACIÓN DE LAS TENSIONES DE CRECIMIENTO EN TRES CLONES DE Eucalyptus grandis SEGÚN EL ESTADO DE COMPETENCIA INDIVIDUAL</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Las tensiones de crecimientos se encuentran en todas las especies forestales, siendo en algunas l...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Las tensiones de crecimientos se encuentran en todas las especies forestales, siendo en algunas latifoliadas consideradas como el principal defecto. Dichas tensiones se generan durante el crecimiento y maduración de las células producidas año a año por el cambium. En ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232189"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232189"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232189; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232189]").text(description); $(".js-view-count[data-work-id=12232189]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232189; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232189']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232189, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12232189]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232189,"title":"VARIACIÓN DE LAS TENSIONES DE CRECIMIENTO EN TRES CLONES DE Eucalyptus grandis SEGÚN EL ESTADO DE COMPETENCIA INDIVIDUAL","translated_title":"","metadata":{"abstract":"Las tensiones de crecimientos se encuentran en todas las especies forestales, siendo en algunas latifoliadas consideradas como el principal defecto. 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En ...","internal_url":"https://www.academia.edu/12232189/VARIACI%C3%93N_DE_LAS_TENSIONES_DE_CRECIMIENTO_EN_TRES_CLONES_DE_Eucalyptus_grandis_SEG%C3%9AN_EL_ESTADO_DE_COMPETENCIA_INDIVIDUAL","translated_internal_url":"","created_at":"2015-05-04T13:47:04.613-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":30716972,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"VARIACIÓN_DE_LAS_TENSIONES_DE_CRECIMIENTO_EN_TRES_CLONES_DE_Eucalyptus_grandis_SEGÚN_EL_ESTADO_DE_COMPETENCIA_INDIVIDUAL","translated_slug":"","page_count":null,"language":"es","content_type":"Work","owner":{"id":30716972,"first_name":"JUAN","middle_initials":null,"last_name":"LOPEZ","page_name":"JUANLOPEZ","domain_name":"unearte","created_at":"2015-05-04T06:29:21.113-07:00","display_name":"JUAN LOPEZ","url":"https://unearte.academia.edu/JUANLOPEZ"},"attachments":[],"research_interests":[{"id":1426166,"name":"Eucalyptus Grandis","url":"https://www.academia.edu/Documents/in/Eucalyptus_Grandis"}],"urls":[{"id":4738441,"url":"http://www.inta.gov.ar/bellavista/congresos/2007/jor.ftal04.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232188"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/12232188/A_User_Interface_for_the_Design_of_Human_Figures_Multimedia_Animations"><img alt="Research paper thumbnail of A User Interface for the Design of Human Figures Multimedia Animations" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/12232188/A_User_Interface_for_the_Design_of_Human_Figures_Multimedia_Animations">A User Interface for the Design of Human Figures Multimedia Animations</a></div><div class="wp-workCard_item"><span>Hypertext, Information Retrieval, Multimedia</span><span>, 1997</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This paper presents the design and development of a visual computer system for the modelling and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This paper presents the design and development of a visual computer system for the modelling and simulation of human movements. The interface allows human figure movements to be generated in a graphical and intuitive way, accomplishing human-computer interaction through 3D icons-graphics. In the implementation object oriented programming methodology is used. A hierarchical dependency between the members of the human body</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232188"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232188"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232188; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232188]").text(description); $(".js-view-count[data-work-id=12232188]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232188; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232188']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232188, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12232188]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232188,"title":"A User Interface for the Design of Human Figures Multimedia Animations","translated_title":"","metadata":{"abstract":"This paper presents the design and development of a visual computer system for the modelling and simulation of human movements. 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Neutrophils are able to produce extracellular traps (NETs) in response to medically important fungi including Aspergillus spp., Candida albicans and Cryptococcus gattii. However, NET production in response to Paracoccidioides brasiliensis has yet to be studied. We have demonstrated that human neutrophils produce NETs against both conidia and yeasts of P. brasiliensis. Although the NADPH oxidase inhibitor DPI did not alter NET production against conidia, it partially suppressed NET formation against P. brasiliensis yeasts. Cytochalasin-D or IFN-γ did not affect the production of NETs against the fungus. Additionally, a mutant strain of P. brasiliensis with reduced expression of an alternative oxidase (AOX) induced significantly higher levels of NETs in comparison with the wild type strain. Finally, CFU quantification of P. brasiliensis showed no significant d...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="65d1f7dcf4fe44e6e81dfb7ff969ced5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46291434,"asset_id":12232187,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46291434/download_file?st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232187"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232187"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232187; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232187]").text(description); $(".js-view-count[data-work-id=12232187]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232187; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232187']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232187, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "65d1f7dcf4fe44e6e81dfb7ff969ced5" } } $('.js-work-strip[data-work-id=12232187]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232187,"title":"Human neutrophils produce extracellular traps against Paracoccidioides brasiliensis","translated_title":"","metadata":{"abstract":"Neutrophils play an important role as effector cells and contribute to the resistance of the host against microbial pathogens. Neutrophils are able to produce extracellular traps (NETs) in response to medically important fungi including Aspergillus spp., Candida albicans and Cryptococcus gattii. However, NET production in response to Paracoccidioides brasiliensis has yet to be studied. We have demonstrated that human neutrophils produce NETs against both conidia and yeasts of P. brasiliensis. Although the NADPH oxidase inhibitor DPI did not alter NET production against conidia, it partially suppressed NET formation against P. brasiliensis yeasts. Cytochalasin-D or IFN-γ did not affect the production of NETs against the fungus. Additionally, a mutant strain of P. brasiliensis with reduced expression of an alternative oxidase (AOX) induced significantly higher levels of NETs in comparison with the wild type strain. Finally, CFU quantification of P. brasiliensis showed no significant d...","publication_date":{"day":20,"month":1,"year":2015,"errors":{}},"publication_name":"Microbiology (Reading, England)"},"translated_abstract":"Neutrophils play an important role as effector cells and contribute to the resistance of the host against microbial pathogens. Neutrophils are able to produce extracellular traps (NETs) in response to medically important fungi including Aspergillus spp., Candida albicans and Cryptococcus gattii. However, NET production in response to Paracoccidioides brasiliensis has yet to be studied. We have demonstrated that human neutrophils produce NETs against both conidia and yeasts of P. brasiliensis. Although the NADPH oxidase inhibitor DPI did not alter NET production against conidia, it partially suppressed NET formation against P. brasiliensis yeasts. Cytochalasin-D or IFN-γ did not affect the production of NETs against the fungus. Additionally, a mutant strain of P. brasiliensis with reduced expression of an alternative oxidase (AOX) induced significantly higher levels of NETs in comparison with the wild type strain. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232186"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12232186/The_effect_of_IFN_gamma_and_TNF_alpha_on_the_eosinophilic_differentiation_and_NADPH_oxidase_activation_of_human_HL_60_clone_15_cells"><img alt="Research paper thumbnail of The effect of IFN-gamma and TNF-alpha on the eosinophilic differentiation and NADPH oxidase activation of human HL-60 clone 15 cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12232186/The_effect_of_IFN_gamma_and_TNF_alpha_on_the_eosinophilic_differentiation_and_NADPH_oxidase_activation_of_human_HL_60_clone_15_cells">The effect of IFN-gamma and TNF-alpha on the eosinophilic differentiation and NADPH oxidase activation of human HL-60 clone 15 cells</a></div><div class="wp-workCard_item"><span>Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of this study was to investigate the effect of interferon-gamma (IFN-gamma) and tumor nec...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of this study was to investigate the effect of interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on NADPH oxidase activity and gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage. The results were compared to the eosoniphilic inducers interleukin-5 (IL-5) and butyric acid. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) or IL-5 (200 pM) caused a significant increase in the expression of the eosinophil peroxidase (EPO) and the major basic protein (MBP) genes. Similar results were observed when the cells were cultured with 0.5 mM butyric acid for 5 days. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) also caused a significant increase in superoxide release by HL-60 clone 15 cells after 2 days compared with control or with butyric acid-induced cells. After 5 days, these cytokines and butyric acid induced an even stronger release of superoxide. HL-60 clone 15 cells cultured with IFN-gamma and TNF-alpha for ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232186"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232186"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232186; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232186]").text(description); $(".js-view-count[data-work-id=12232186]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232186; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232186']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232186, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12232186]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232186,"title":"The effect of IFN-gamma and TNF-alpha on the eosinophilic differentiation and NADPH oxidase activation of human HL-60 clone 15 cells","translated_title":"","metadata":{"abstract":"The aim of this study was to investigate the effect of interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on NADPH oxidase activity and gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage. The results were compared to the eosoniphilic inducers interleukin-5 (IL-5) and butyric acid. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) or IL-5 (200 pM) caused a significant increase in the expression of the eosinophil peroxidase (EPO) and the major basic protein (MBP) genes. Similar results were observed when the cells were cultured with 0.5 mM butyric acid for 5 days. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) also caused a significant increase in superoxide release by HL-60 clone 15 cells after 2 days compared with control or with butyric acid-induced cells. After 5 days, these cytokines and butyric acid induced an even stronger release of superoxide. HL-60 clone 15 cells cultured with IFN-gamma and TNF-alpha for ...","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"Journal of interferon \u0026 cytokine research : the official journal of the International Society for Interferon and Cytokine Research"},"translated_abstract":"The aim of this study was to investigate the effect of interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on NADPH oxidase activity and gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage. The results were compared to the eosoniphilic inducers interleukin-5 (IL-5) and butyric acid. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) or IL-5 (200 pM) caused a significant increase in the expression of the eosinophil peroxidase (EPO) and the major basic protein (MBP) genes. Similar results were observed when the cells were cultured with 0.5 mM butyric acid for 5 days. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) also caused a significant increase in superoxide release by HL-60 clone 15 cells after 2 days compared with control or with butyric acid-induced cells. After 5 days, these cytokines and butyric acid induced an even stronger release of superoxide. HL-60 clone 15 cells cultured with IFN-gamma and TNF-alpha for ...","internal_url":"https://www.academia.edu/12232186/The_effect_of_IFN_gamma_and_TNF_alpha_on_the_eosinophilic_differentiation_and_NADPH_oxidase_activation_of_human_HL_60_clone_15_cells","translated_internal_url":"","created_at":"2015-05-04T13:47:04.233-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":30716972,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"The_effect_of_IFN_gamma_and_TNF_alpha_on_the_eosinophilic_differentiation_and_NADPH_oxidase_activation_of_human_HL_60_clone_15_cells","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":30716972,"first_name":"JUAN","middle_initials":null,"last_name":"LOPEZ","page_name":"JUANLOPEZ","domain_name":"unearte","created_at":"2015-05-04T06:29:21.113-07:00","display_name":"JUAN LOPEZ","url":"https://unearte.academia.edu/JUANLOPEZ"},"attachments":[],"research_interests":[{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":55175,"name":"Peroxidase","url":"https://www.academia.edu/Documents/in/Peroxidase"},{"id":57802,"name":"Erythropoietin","url":"https://www.academia.edu/Documents/in/Erythropoietin"},{"id":60436,"name":"Cell Differentiation","url":"https://www.academia.edu/Documents/in/Cell_Differentiation"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":234980,"name":"NADPH oxidase","url":"https://www.academia.edu/Documents/in/NADPH_oxidase"},{"id":341910,"name":"Butyric Acid","url":"https://www.academia.edu/Documents/in/Butyric_Acid"},{"id":371516,"name":"Eosinophils","url":"https://www.academia.edu/Documents/in/Eosinophils"},{"id":474029,"name":"Tumor necrosis factor-alpha","url":"https://www.academia.edu/Documents/in/Tumor_necrosis_factor-alpha"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers"},{"id":1763968,"name":"Gene Expression Regulation","url":"https://www.academia.edu/Documents/in/Gene_Expression_Regulation"},{"id":1924712,"name":"Interleukin","url":"https://www.academia.edu/Documents/in/Interleukin"},{"id":2058663,"name":"Interferon gamma","url":"https://www.academia.edu/Documents/in/Interferon_gamma"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232185"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12232185/Proteomic_characterization_of_human_coronary_thrombus_in_patients_with_ST_segment_elevation_acute_myocardial_infarction"><img alt="Research paper thumbnail of Proteomic characterization of human coronary thrombus in patients with ST-segment elevation acute myocardial infarction" class="work-thumbnail" src="https://attachments.academia-assets.com/46291600/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12232185/Proteomic_characterization_of_human_coronary_thrombus_in_patients_with_ST_segment_elevation_acute_myocardial_infarction">Proteomic characterization of human coronary thrombus in patients with ST-segment elevation acute myocardial infarction</a></div><div class="wp-workCard_item"><span>Journal of proteomics</span><span>, Jan 23, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Acute myocardial infarction with ST-segment elevation (STEMI) initiates with intraluminal thrombo...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Acute myocardial infarction with ST-segment elevation (STEMI) initiates with intraluminal thrombosis and results in total occlusion of the coronary artery. To date, characterization of the coronary thrombus proteome in STEMI patients has not been yet accomplished. Therefore, we aimed to perform an in-depth proteomic characterization of the human coronary thrombus by means of three different approaches: 2-DE followed by mass spectrometry (MALDI MS/MS), 1-DE combined either with liquid chromatography coupled to mass spectrometry in a MALDI TOF/TOF (LC-MALDI-MS/MS), or in a LTQ-Orbitrap (LC-ESI-MS/MS). This approach allowed us to identify a total of 708 proteins in the thrombus. Expression in coronary thrombi (n=20) of 14 proteins was verified, and the expression of fibrin and 6 cell markers (platelets, monocytes, neutrophils, eosinophils, T-cells and B-cells) quantified by selected reaction monitoring (SRM). A positive correlation of 5 proteins (fermitin homolog 3, thrombospondin-1, m...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1f759ec710e94a7db79829d2318cda3b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46291600,"asset_id":12232185,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46291600/download_file?st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232185"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232185"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232185; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232185]").text(description); $(".js-view-count[data-work-id=12232185]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232185; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232185']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232185, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1f759ec710e94a7db79829d2318cda3b" } } $('.js-work-strip[data-work-id=12232185]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232185,"title":"Proteomic characterization of human coronary thrombus in patients with ST-segment elevation acute myocardial infarction","translated_title":"","metadata":{"abstract":"Acute myocardial infarction with ST-segment elevation (STEMI) initiates with intraluminal thrombosis and results in total occlusion of the coronary artery. To date, characterization of the coronary thrombus proteome in STEMI patients has not been yet accomplished. Therefore, we aimed to perform an in-depth proteomic characterization of the human coronary thrombus by means of three different approaches: 2-DE followed by mass spectrometry (MALDI MS/MS), 1-DE combined either with liquid chromatography coupled to mass spectrometry in a MALDI TOF/TOF (LC-MALDI-MS/MS), or in a LTQ-Orbitrap (LC-ESI-MS/MS). This approach allowed us to identify a total of 708 proteins in the thrombus. Expression in coronary thrombi (n=20) of 14 proteins was verified, and the expression of fibrin and 6 cell markers (platelets, monocytes, neutrophils, eosinophils, T-cells and B-cells) quantified by selected reaction monitoring (SRM). A positive correlation of 5 proteins (fermitin homolog 3, thrombospondin-1, m...","publication_date":{"day":23,"month":1,"year":2014,"errors":{}},"publication_name":"Journal of proteomics"},"translated_abstract":"Acute myocardial infarction with ST-segment elevation (STEMI) initiates with intraluminal thrombosis and results in total occlusion of the coronary artery. To date, characterization of the coronary thrombus proteome in STEMI patients has not been yet accomplished. Therefore, we aimed to perform an in-depth proteomic characterization of the human coronary thrombus by means of three different approaches: 2-DE followed by mass spectrometry (MALDI MS/MS), 1-DE combined either with liquid chromatography coupled to mass spectrometry in a MALDI TOF/TOF (LC-MALDI-MS/MS), or in a LTQ-Orbitrap (LC-ESI-MS/MS). This approach allowed us to identify a total of 708 proteins in the thrombus. Expression in coronary thrombi (n=20) of 14 proteins was verified, and the expression of fibrin and 6 cell markers (platelets, monocytes, neutrophils, eosinophils, T-cells and B-cells) quantified by selected reaction monitoring (SRM). 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232184"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12232184/Pharmacological_Profiles_of_Acute_Myeloid_Leukemia_Treatments_in_Patient_Samples_by_Automated_Flow_Cytometry_A_Bridge_to_Individualized_Medicine"><img alt="Research paper thumbnail of Pharmacological Profiles of Acute Myeloid Leukemia Treatments in Patient Samples by Automated Flow Cytometry: A Bridge to Individualized Medicine" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12232184/Pharmacological_Profiles_of_Acute_Myeloid_Leukemia_Treatments_in_Patient_Samples_by_Automated_Flow_Cytometry_A_Bridge_to_Individualized_Medicine">Pharmacological Profiles of Acute Myeloid Leukemia Treatments in Patient Samples by Automated Flow Cytometry: A Bridge to Individualized Medicine</a></div><div class="wp-workCard_item"><span>Clinical Lymphoma Myeloma and Leukemia</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We have evaluated the ex vivo pharmacology of single drugs and drug combinations in malignant cel...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We have evaluated the ex vivo pharmacology of single drugs and drug combinations in malignant cells of bone marrow samples from 125 patients with acute myeloid leukemia using a novel automated flow cytometry-based platform (ExviTech). We have improved previous ex vivo drug testing with 4 innovations: identifying individual leukemic cells, using intact whole blood during the incubation, using an automated platform that escalates reliably data, and performing analyses pharmacodynamic population models. Samples were sent from 24 hospitals to a central laboratory and incubated for 48 hours in whole blood, after which drug activity was measured in terms of depletion of leukemic cells. The sensitivity of single drugs is assessed for standard efficacy (EMAX) and potency (EC50) variables, ranked as percentiles within the population. The sensitivity of drug-combination treatments is assessed for the synergism achieved in each patient sample. We found a large variability among patient samples in the dose-response curves to a single drug or combination treatment. We hypothesize that the use of the individual patient ex vivo pharmacological profiles may help to guide a personalized treatment selection.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232184"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232184"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232184; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232184]").text(description); $(".js-view-count[data-work-id=12232184]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232184; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232184']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232184, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12232184]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232184,"title":"Pharmacological Profiles of Acute Myeloid Leukemia Treatments in Patient Samples by Automated Flow Cytometry: A Bridge to Individualized Medicine","translated_title":"","metadata":{"abstract":"We have evaluated the ex vivo pharmacology of single drugs and drug combinations in malignant cells of bone marrow samples from 125 patients with acute myeloid leukemia using a novel automated flow cytometry-based platform (ExviTech). We have improved previous ex vivo drug testing with 4 innovations: identifying individual leukemic cells, using intact whole blood during the incubation, using an automated platform that escalates reliably data, and performing analyses pharmacodynamic population models. Samples were sent from 24 hospitals to a central laboratory and incubated for 48 hours in whole blood, after which drug activity was measured in terms of depletion of leukemic cells. The sensitivity of single drugs is assessed for standard efficacy (EMAX) and potency (EC50) variables, ranked as percentiles within the population. The sensitivity of drug-combination treatments is assessed for the synergism achieved in each patient sample. We found a large variability among patient samples in the dose-response curves to a single drug or combination treatment. We hypothesize that the use of the individual patient ex vivo pharmacological profiles may help to guide a personalized treatment selection.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Clinical Lymphoma Myeloma and Leukemia"},"translated_abstract":"We have evaluated the ex vivo pharmacology of single drugs and drug combinations in malignant cells of bone marrow samples from 125 patients with acute myeloid leukemia using a novel automated flow cytometry-based platform (ExviTech). We have improved previous ex vivo drug testing with 4 innovations: identifying individual leukemic cells, using intact whole blood during the incubation, using an automated platform that escalates reliably data, and performing analyses pharmacodynamic population models. Samples were sent from 24 hospitals to a central laboratory and incubated for 48 hours in whole blood, after which drug activity was measured in terms of depletion of leukemic cells. The sensitivity of single drugs is assessed for standard efficacy (EMAX) and potency (EC50) variables, ranked as percentiles within the population. The sensitivity of drug-combination treatments is assessed for the synergism achieved in each patient sample. We found a large variability among patient samples in the dose-response curves to a single drug or combination treatment. We hypothesize that the use of the individual patient ex vivo pharmacological profiles may help to guide a personalized treatment selection.","internal_url":"https://www.academia.edu/12232184/Pharmacological_Profiles_of_Acute_Myeloid_Leukemia_Treatments_in_Patient_Samples_by_Automated_Flow_Cytometry_A_Bridge_to_Individualized_Medicine","translated_internal_url":"","created_at":"2015-05-04T13:47:03.986-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":30716972,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Pharmacological_Profiles_of_Acute_Myeloid_Leukemia_Treatments_in_Patient_Samples_by_Automated_Flow_Cytometry_A_Bridge_to_Individualized_Medicine","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":30716972,"first_name":"JUAN","middle_initials":null,"last_name":"LOPEZ","page_name":"JUANLOPEZ","domain_name":"unearte","created_at":"2015-05-04T06:29:21.113-07:00","display_name":"JUAN LOPEZ","url":"https://unearte.academia.edu/JUANLOPEZ"},"attachments":[],"research_interests":[{"id":6599,"name":"Flow Cytometry","url":"https://www.academia.edu/Documents/in/Flow_Cytometry"},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome"},{"id":58380,"name":"Therapeutic drug monitoring","url":"https://www.academia.edu/Documents/in/Therapeutic_drug_monitoring"},{"id":59057,"name":"Acute Myeloid Leukemia","url":"https://www.academia.edu/Documents/in/Acute_Myeloid_Leukemia"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":295155,"name":"Middle Aged","url":"https://www.academia.edu/Documents/in/Middle_Aged"},{"id":382075,"name":"Adult","url":"https://www.academia.edu/Documents/in/Adult"},{"id":820718,"name":"Individualized Medicine","url":"https://www.academia.edu/Documents/in/Individualized_Medicine"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival"},{"id":1212103,"name":"Antineoplastic Agents","url":"https://www.academia.edu/Documents/in/Antineoplastic_Agents"},{"id":1664707,"name":"Bone Marrow Cells","url":"https://www.academia.edu/Documents/in/Bone_Marrow_Cells"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232183"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12232183/The_millimeter_wave_spectrum_of_cyclopentene"><img alt="Research paper thumbnail of The millimeter-wave spectrum of cyclopentene" class="work-thumbnail" src="https://attachments.academia-assets.com/46291432/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12232183/The_millimeter_wave_spectrum_of_cyclopentene">The millimeter-wave spectrum of cyclopentene</a></div><div class="wp-workCard_item"><span>Journal of Molecular Spectroscopy - J MOL SPECTROSC</span><span>, 1992</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e85e4871f1a161c966cc0a9a14ff848b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46291432,"asset_id":12232183,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46291432/download_file?st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232183"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232183"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232183; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232183]").text(description); $(".js-view-count[data-work-id=12232183]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232183; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232183']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232183, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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A two-state analysis of the vibration-rotation interaction for the u = 0 and D = 1 states gives an energy separation between these states of 0.91173 l(6) cm-'. The ring-puckering vibrational dependence of the rotational constants has been analyzed in terms of a reduced vibrational Hamiltonian with kinetic energy terms including the ring-puckering dependence of the reduced mass. The vibrational dependence of the quartic centrifugal distortion constants, including a small dependence of A, and b, has been aCCOUnted for. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232182"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12232182/Expression_of_the_adrenomedullin_binding_protein_complement_factor_H_in_the_pancreas_and_its_physiological_impact_on_insulin_secretion"><img alt="Research paper thumbnail of Expression of the adrenomedullin binding protein, complement factor H, in the pancreas and its physiological impact on insulin secretion" class="work-thumbnail" src="https://attachments.academia-assets.com/46291426/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12232182/Expression_of_the_adrenomedullin_binding_protein_complement_factor_H_in_the_pancreas_and_its_physiological_impact_on_insulin_secretion">Expression of the adrenomedullin binding protein, complement factor H, in the pancreas and its physiological impact on insulin secretion</a></div><div class="wp-workCard_item"><span>Journal of Endocrinology - J ENDOCRINOL</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Adrenomedullin (AM) is a ubiquitous peptide hormone which, among other functional roles, reduces ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Adrenomedullin (AM) is a ubiquitous peptide hormone which, among other functional roles, reduces insulin secretion in the pancreas. Recently we have described the interaction between AM and the complement regulator protein factor H, which results in mutual modulation of their respective functions. Here we identify the expression of factor H in the cells of the rat pancreatic islets by immunohistochemistry and multiple immunofluorescence followed by confocal microscopy. In addition, double immunogold staining under the electron microscope showed coexistence of insulin and factor H immuno- reactivities within the same secretory granules; interest- ingly, factor H staining was found in the electron-lucent haloes whereas the insulin antibody labeled preferentially the dense cores. The existence of factor H mRNA in the pancreas was confirmed by RT-PCR and in situ hybrid- ization. The function of factor H in the pancreas was investigated with an insulin secretion assay. Addition of factor...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="aa9f64c1013ee3a0c2e89f8cae404850" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46291426,"asset_id":12232182,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46291426/download_file?st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232182"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232182"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232182; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232182]").text(description); $(".js-view-count[data-work-id=12232182]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232182; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232182']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232182, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "aa9f64c1013ee3a0c2e89f8cae404850" } } $('.js-work-strip[data-work-id=12232182]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232182,"title":"Expression of the adrenomedullin binding protein, complement factor H, in the pancreas and its physiological impact on insulin secretion","translated_title":"","metadata":{"abstract":"Adrenomedullin (AM) is a ubiquitous peptide hormone which, among other functional roles, reduces insulin secretion in the pancreas. Recently we have described the interaction between AM and the complement regulator protein factor H, which results in mutual modulation of their respective functions. Here we identify the expression of factor H in the cells of the rat pancreatic islets by immunohistochemistry and multiple immunofluorescence followed by confocal microscopy. In addition, double immunogold staining under the electron microscope showed coexistence of insulin and factor H immuno- reactivities within the same secretory granules; interest- ingly, factor H staining was found in the electron-lucent haloes whereas the insulin antibody labeled preferentially the dense cores. The existence of factor H mRNA in the pancreas was confirmed by RT-PCR and in situ hybrid- ization. The function of factor H in the pancreas was investigated with an insulin secretion assay. Addition of factor...","publication_date":{"day":null,"month":null,"year":2001,"errors":{}},"publication_name":"Journal of Endocrinology - J ENDOCRINOL"},"translated_abstract":"Adrenomedullin (AM) is a ubiquitous peptide hormone which, among other functional roles, reduces insulin secretion in the pancreas. Recently we have described the interaction between AM and the complement regulator protein factor H, which results in mutual modulation of their respective functions. Here we identify the expression of factor H in the cells of the rat pancreatic islets by immunohistochemistry and multiple immunofluorescence followed by confocal microscopy. In addition, double immunogold staining under the electron microscope showed coexistence of insulin and factor H immuno- reactivities within the same secretory granules; interest- ingly, factor H staining was found in the electron-lucent haloes whereas the insulin antibody labeled preferentially the dense cores. 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factor...","internal_url":"https://www.academia.edu/12232182/Expression_of_the_adrenomedullin_binding_protein_complement_factor_H_in_the_pancreas_and_its_physiological_impact_on_insulin_secretion","translated_internal_url":"","created_at":"2015-05-04T13:47:03.616-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":30716972,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":46291426,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/46291426/thumbnails/1.jpg","file_name":"503.pdf","download_url":"https://www.academia.edu/attachments/46291426/download_file?st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Expression_of_the_adrenomedullin_binding.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/46291426/503-libre.pdf?1465252052=\u0026response-content-disposition=attachment%3B+filename%3DExpression_of_the_adrenomedullin_binding.pdf\u0026Expires=1732408219\u0026Signature=OQdBOJg4qHGQrkqbxaZfOK3I~72XYOvVFWLCqLOe1l9nIL9Wi-DucZkX1D4ZmZX55yWh0YzeS3MFgvoAnEt3h58iylrRKoujNDCBsluv9csq4IrXHrxmjMYQEBptB7M3PkvNRLieQgXYPBnVUtK3MZR7GfYvHXrxnCNLKClOMijOJHpiqWzCV7cJ0SAEGgmEymZtBEuMkmdoI32am9vHjvV3mDCBDPfdpwUMhnPMOMLRduQeg5zTfLynJ4yOcKKJtxBBnbozYbuqxTAGXe38CeeOBxVpdxYaA53fhi-vIM-HrE0O5fqO1PjiTdU5kMcWU4EhpIxEVMQrztUg8s5E5A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Expression_of_the_adrenomedullin_binding_protein_complement_factor_H_in_the_pancreas_and_its_physiological_impact_on_insulin_secretion","translated_slug":"","page_count":9,"language":"en","content_type":"Work","owner":{"id":30716972,"first_name":"JUAN","middle_initials":null,"last_name":"LOPEZ","page_name":"JUANLOPEZ","domain_name":"unearte","created_at":"2015-05-04T06:29:21.113-07:00","display_name":"JUAN 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A novel lignan type from juniperus thurifera l" class="work-thumbnail" src="https://attachments.academia-assets.com/46291429/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12232181/Thuriferic_acid_A_novel_lignan_type_from_juniperus_thurifera_l">Thuriferic acid. A novel lignan type from juniperus thurifera l</a></div><div class="wp-workCard_item"><span>Tetrahedron</span><span>, 1988</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1f5053f454aa9662449a058e95552810" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46291429,"asset_id":12232181,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46291429/download_file?st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232181"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232181"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232181; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232181]").text(description); $(".js-view-count[data-work-id=12232181]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232181; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232181']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232181, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1f5053f454aa9662449a058e95552810" } } $('.js-work-strip[data-work-id=12232181]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232181,"title":"Thuriferic acid. A novel lignan type from juniperus thurifera l","translated_title":"","metadata":{"grobid_abstract":"The isolation and structural determination of a novel type of lignan, thuriferic acid, obtained from the hexane extract of the leaves of Juniperus tkurifera L (Cupressaceae) are described. 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Tratamiento combinado con hemodiálisis y hemofiltración","translated_title":"","metadata":{"grobid_abstract":"Presentamos un caso de acidosis láctica grave secundaria al consumo de metformina. Mujer de 61 años de edad con antecedentes de diabetes mellitus que prosiguió el tratamiento con metformina a pesar de estar en ayunas por intolerancia oral a alimentos y vómitos durante una semana. Presentó acidosis láctica grave (pH, 7,03; bicarbonato, 3,6 mEq/l; lactato, 18,58 mEq/l) e insuficiencia renal aguda (urea, 17,9 mmol/l; creatinina, 634 mmol/l; Na+, 144 mmol/l; K+, 5,7 mmol/l), a pesar del tratamiento con hemodiálisis y bicarbonato intravenoso, y posteriormente requirió hemodiafiltración venovenosa continua, 2 sesiones de 8 h. Su curso evolutivo resultó satisfactorio. La asociación de metformina y acidosis láctica comporta un alto índice de mortalidad. Las técnicas de depuración extrarrenal continuas deberían considerarse como tratamiento precoz en los casos en que haya esta asociación.","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"grobid_abstract_attachment_id":46291447},"translated_abstract":null,"internal_url":"https://www.academia.edu/12232180/Acidosis_l%C3%A1ctica_y_metformina_Tratamiento_combinado_con_hemodi%C3%A1lisis_y_hemofiltraci%C3%B3n","translated_internal_url":"","created_at":"2015-05-04T13:47:03.170-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":30716972,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":46291447,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/46291447/thumbnails/1.jpg","file_name":"Acidosis_lctica_y_metformina._Tratamient20160606-2677-j0x6ym.pdf","download_url":"https://www.academia.edu/attachments/46291447/download_file?st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Acidosis_lactica_y_metformina_Tratamient.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/46291447/Acidosis_lctica_y_metformina._Tratamient20160606-2677-j0x6ym-libre.pdf?1465252051=\u0026response-content-disposition=attachment%3B+filename%3DAcidosis_lactica_y_metformina_Tratamient.pdf\u0026Expires=1732408219\u0026Signature=RvpktKP5xU4XXer4qhKkeJj-byZD62ho2gVFM5OXkFNSKmmOupbR7Z2cdiMU9PKOdgvsk8QveSrtiD9DFM4io4BY4AQnrQaHhk~E~Z1JshEJnvlYgzRSbk6BsCxsrnK9HKmFD317eeT3-zTMr76hmtqX-jEj88-~7QkFDF0C-p0LTTE-a0LebjJDOfqtuBrxymTAUN05AHbk2AtwKNwdBgpCnI5hke5W-AeZlU7zBgsfpRINu~UsmunOPMdJ9H~mbsg06SMet3AOFQtcJJa2P3JNKrgELjXdzJ~QwXgz3S7F6v-27sf-QRAJwWKJxdEYRUgc49z-xR~1NMYnv8uKqg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Acidosis_láctica_y_metformina_Tratamiento_combinado_con_hemodiálisis_y_hemofiltración","translated_slug":"","page_count":4,"language":"es","content_type":"Work","owner":{"id":30716972,"first_name":"JUAN","middle_initials":null,"last_name":"LOPEZ","page_name":"JUANLOPEZ","domain_name":"unearte","created_at":"2015-05-04T06:29:21.113-07:00","display_name":"JUAN LOPEZ","url":"https://unearte.academia.edu/JUANLOPEZ"},"attachments":[{"id":46291447,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/46291447/thumbnails/1.jpg","file_name":"Acidosis_lctica_y_metformina._Tratamient20160606-2677-j0x6ym.pdf","download_url":"https://www.academia.edu/attachments/46291447/download_file?st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Acidosis_lactica_y_metformina_Tratamient.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/46291447/Acidosis_lctica_y_metformina._Tratamient20160606-2677-j0x6ym-libre.pdf?1465252051=\u0026response-content-disposition=attachment%3B+filename%3DAcidosis_lactica_y_metformina_Tratamient.pdf\u0026Expires=1732408219\u0026Signature=RvpktKP5xU4XXer4qhKkeJj-byZD62ho2gVFM5OXkFNSKmmOupbR7Z2cdiMU9PKOdgvsk8QveSrtiD9DFM4io4BY4AQnrQaHhk~E~Z1JshEJnvlYgzRSbk6BsCxsrnK9HKmFD317eeT3-zTMr76hmtqX-jEj88-~7QkFDF0C-p0LTTE-a0LebjJDOfqtuBrxymTAUN05AHbk2AtwKNwdBgpCnI5hke5W-AeZlU7zBgsfpRINu~UsmunOPMdJ9H~mbsg06SMet3AOFQtcJJa2P3JNKrgELjXdzJ~QwXgz3S7F6v-27sf-QRAJwWKJxdEYRUgc49z-xR~1NMYnv8uKqg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":101212,"name":"Hemodialysis","url":"https://www.academia.edu/Documents/in/Hemodialysis"}],"urls":[{"id":4738436,"url":"http://www.sciencedirect.com/science/article/pii/S1575092207714936"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232179"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12232179/Microwave_spectra_and_internal_rotation_in_%CE%B1_angelicalactone"><img alt="Research paper thumbnail of Microwave spectra and internal rotation in α-angelicalactone" class="work-thumbnail" src="https://attachments.academia-assets.com/46291430/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12232179/Microwave_spectra_and_internal_rotation_in_%CE%B1_angelicalactone">Microwave spectra and internal rotation in α-angelicalactone</a></div><div class="wp-workCard_item"><span>Journal of Molecular Spectroscopy</span><span>, 1987</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="78ad5493dcc5efe718991c769a4343d6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46291430,"asset_id":12232179,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46291430/download_file?st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232179"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232179"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232179; 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The internal rotation barrier of the methyl group has been determined in the ground and four vibrationally excited states from the A-E splittings. The results indicate a possible interaction between the methyl torsion and the ring puckering mode. The ground state rotational parameters are consistent with a planar ring skeleton. 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The enviomment is for an embedded processor used for audio decompression algorithms including: MPEG2, Dolby AC-3 Sumd and Dolby Pro-logic. The enabling component of the jmware environment is a retargetable compiler which maps high-level algorithm onto the embedded processox Although compilation is the critical technoba, this eqerience has shown that it is imujicient and that other supporting design tools are also importam. For this project, that environment includes an instruction-set simulator; a sowe-bel debugger; a custom linkel; and a compiler validation strategy The methodologies are ourlined in this paper with an emphasis on the lessons learned in this hardware-somare team devebpmt.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="48144fb13c753fff66160b0ddd65f092" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":46291451,"asset_id":12232176,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/46291451/download_file?st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&st=MTczMjQwNDYxOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232176"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232176"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232176; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232176]").text(description); $(".js-view-count[data-work-id=12232176]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232176; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232176']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232176, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "48144fb13c753fff66160b0ddd65f092" } } $('.js-work-strip[data-work-id=12232176]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232176,"title":"An Embedded System Case Study: The Firm Ware Development Environment For A Multimedia Audio Processor","translated_title":"","metadata":{"abstract":"Ris paper outlines a case study at SGS-Thomson Mkroelec-honks on the development of a frmware development environment in cooperation with ”son Consumer Electmnics Componknts. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232173"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/12232173/Analysis_of_genomic_variability_in_transgenic_sugarcane_plants_produced_by_Agrobacterium_tumefaciens_infection"><img alt="Research paper thumbnail of Analysis of genomic variability in transgenic sugarcane plants produced by Agrobacterium tumefaciens infection" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/12232173/Analysis_of_genomic_variability_in_transgenic_sugarcane_plants_produced_by_Agrobacterium_tumefaciens_infection">Analysis of genomic variability in transgenic sugarcane plants produced by Agrobacterium tumefaciens infection</a></div><div class="wp-workCard_item"><span>Plant …</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... Arencibia, A., E. Carmona, MT Cornide, S. Castiglione, J. O&#x27;Relly, A. Chinea, P. Oramas,...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... Arencibia, A., E. Carmona, MT Cornide, S. Castiglione, J. O&#x27;Relly, A. Chinea, P. Oramas, and F. Sala, 1999: Somaclonal variation in ... Heinz, DJ, and GW Mee, 1970: Morphologic cytogenetic and enzymatic variation in Saccharum species hybrid clones derived from callus tissue. ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232173"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232173"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232173; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232173]").text(description); $(".js-view-count[data-work-id=12232173]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232173; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232173']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232173, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12232173]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232173,"title":"Analysis of genomic variability in transgenic sugarcane plants produced by Agrobacterium tumefaciens infection","translated_title":"","metadata":{"abstract":"... 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Heinz, DJ, and GW Mee, 1970: Morphologic cytogenetic and enzymatic variation in Saccharum species hybrid clones derived from callus tissue. ...","internal_url":"https://www.academia.edu/12232173/Analysis_of_genomic_variability_in_transgenic_sugarcane_plants_produced_by_Agrobacterium_tumefaciens_infection","translated_internal_url":"","created_at":"2015-05-04T13:47:01.478-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":30716972,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Analysis_of_genomic_variability_in_transgenic_sugarcane_plants_produced_by_Agrobacterium_tumefaciens_infection","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":30716972,"first_name":"JUAN","middle_initials":null,"last_name":"LOPEZ","page_name":"JUANLOPEZ","domain_name":"unearte","created_at":"2015-05-04T06:29:21.113-07:00","display_name":"JUAN LOPEZ","url":"https://unearte.academia.edu/JUANLOPEZ"},"attachments":[],"research_interests":[{"id":5541,"name":"Plant Biology","url":"https://www.academia.edu/Documents/in/Plant_Biology"},{"id":14933,"name":"Plant Breeding","url":"https://www.academia.edu/Documents/in/Plant_Breeding"},{"id":106562,"name":"Plant","url":"https://www.academia.edu/Documents/in/Plant"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="12232172"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/12232172/The_effect_of_IFN_%CE%B3_and_TNF_%CE%B1_on_the_eosinophilic_differentiation_and_NADPH_oxidase_activation_of_human_HL_60_clone_15_cells"><img alt="Research paper thumbnail of The effect of IFN-γ and TNF-α on the eosinophilic differentiation and NADPH oxidase activation of human HL-60 clone 15 cells" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/12232172/The_effect_of_IFN_%CE%B3_and_TNF_%CE%B1_on_the_eosinophilic_differentiation_and_NADPH_oxidase_activation_of_human_HL_60_clone_15_cells">The effect of IFN-γ and TNF-α on the eosinophilic differentiation and NADPH oxidase activation of human HL-60 clone 15 cells</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of this study was to investigate the effect of interferon-gamma (IFN-gamma) and tumor nec...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of this study was to investigate the effect of interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on NADPH oxidase activity and gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage. The results were compared to the eosoniphilic inducers interleukin-5 (IL-5) and butyric acid. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) or IL-5 (200 pM) caused a significant increase in the expression of the eosinophil peroxidase (EPO) and the major basic protein (MBP) genes. Similar results were observed when the cells were cultured with 0.5 mM butyric acid for 5 days. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) also caused a significant increase in superoxide release by HL-60 clone 15 cells after 2 days compared with control or with butyric acid-induced cells. After 5 days, these cytokines and butyric acid induced an even stronger release of superoxide. HL-60 clone 15 cells cultured with IFN-gamma and TNF-alpha for 2 days showed a significant increase in gp91-phox gene expression. We conclude that IFN-gamma and TNF-alpha are sufficient to induce the differentiation of HL-60 clone 15 cells to the eosinophilic lineage and to upregulate gp91-phox gene expression and activity of the NADPH oxidase system.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="12232172"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="12232172"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 12232172; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=12232172]").text(description); $(".js-view-count[data-work-id=12232172]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 12232172; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='12232172']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 12232172, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=12232172]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":12232172,"title":"The effect of IFN-γ and TNF-α on the eosinophilic differentiation and NADPH oxidase activation of human HL-60 clone 15 cells","translated_title":"","metadata":{"abstract":"The aim of this study was to investigate the effect of interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on NADPH oxidase activity and gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage. The results were compared to the eosoniphilic inducers interleukin-5 (IL-5) and butyric acid. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) or IL-5 (200 pM) caused a significant increase in the expression of the eosinophil peroxidase (EPO) and the major basic protein (MBP) genes. Similar results were observed when the cells were cultured with 0.5 mM butyric acid for 5 days. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) also caused a significant increase in superoxide release by HL-60 clone 15 cells after 2 days compared with control or with butyric acid-induced cells. After 5 days, these cytokines and butyric acid induced an even stronger release of superoxide. HL-60 clone 15 cells cultured with IFN-gamma and TNF-alpha for 2 days showed a significant increase in gp91-phox gene expression. We conclude that IFN-gamma and TNF-alpha are sufficient to induce the differentiation of HL-60 clone 15 cells to the eosinophilic lineage and to upregulate gp91-phox gene expression and activity of the NADPH oxidase system.","publication_date":{"day":null,"month":null,"year":2003,"errors":{}}},"translated_abstract":"The aim of this study was to investigate the effect of interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on NADPH oxidase activity and gp91-phox gene expression in HL-60 clone 15 cells as they differentiate along the eosinophilic lineage. The results were compared to the eosoniphilic inducers interleukin-5 (IL-5) and butyric acid. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) or IL-5 (200 pM) caused a significant increase in the expression of the eosinophil peroxidase (EPO) and the major basic protein (MBP) genes. Similar results were observed when the cells were cultured with 0.5 mM butyric acid for 5 days. IFN-gamma (100 U/ml) and TNF-alpha (1000 U/ml) also caused a significant increase in superoxide release by HL-60 clone 15 cells after 2 days compared with control or with butyric acid-induced cells. After 5 days, these cytokines and butyric acid induced an even stronger release of superoxide. HL-60 clone 15 cells cultured with IFN-gamma and TNF-alpha for 2 days showed a significant increase in gp91-phox gene expression. 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