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class="vector-toc-list"> <li id="toc-Transcriptional_regulation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Transcriptional_regulation"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1</span> <span>Transcriptional regulation</span> </div> </a> <ul id="toc-Transcriptional_regulation-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Cognition_and_emotion" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Cognition_and_emotion"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.2</span> <span>Cognition and emotion</span> </div> </a> <ul id="toc-Cognition_and_emotion-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Stem_cells" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Stem_cells"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.3</span> <span>Stem cells</span> </div> </a> <ul id="toc-Stem_cells-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Structure" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Structure"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Structure</span> </div> </a> <button aria-controls="toc-Structure-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Structure subsection</span> </button> <ul id="toc-Structure-sublist" class="vector-toc-list"> <li id="toc-Gene" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Gene"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>Gene</span> </div> </a> <ul id="toc-Gene-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Protein" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Protein"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2</span> <span>Protein</span> </div> </a> <ul id="toc-Protein-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Clinical_significance" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Clinical_significance"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Clinical significance</span> </div> </a> <ul id="toc-Clinical_significance-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Interactions" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Interactions"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Interactions</span> </div> </a> <ul id="toc-Interactions-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a 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class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" title="Table of Contents" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div 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style="display:none">Protein-coding gene in the species Homo sapiens</div> <p class="mw-empty-elt"> </p> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">KMT2A</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:Protein_MLL_PDB_2j2s.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8c/Protein_MLL_PDB_2j2s.png/250px-Protein_MLL_PDB_2j2s.png" decoding="async" width="250" height="122" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8c/Protein_MLL_PDB_2j2s.png/375px-Protein_MLL_PDB_2j2s.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8c/Protein_MLL_PDB_2j2s.png/500px-Protein_MLL_PDB_2j2s.png 2x" data-file-width="770" data-file-height="377" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Available structures</th></tr><tr><th rowspan="2" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P55200%20or%20Q03164">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P55200,Q03164">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="text-align:center"><th colspan="2" style="background-color:light-dark(#ddd, #404244) !important;color:inherit">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2AGH">2AGH</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2J2S">2J2S</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2JYI">2JYI</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2KKF">2KKF</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2KU7">2KU7</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2KYU">2KYU</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2LXS">2LXS</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2LXT">2LXT</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2MTN">2MTN</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2W5Y">2W5Y</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2W5Z">2W5Z</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3EG6">3EG6</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3EMH">3EMH</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3LQI">3LQI</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3LQJ">3LQJ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3P4F">3P4F</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3U85">3U85</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3U88">3U88</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4ESG">4ESG</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4GQ6">4GQ6</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4NW3">4NW3</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5F6L">5F6L</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5F5E">5F5E</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Identifiers</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/7132">KMT2A</a></span>, ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1, MLL1A, TET1-MLL, TRX1, WDSTS, MLL-AF9, lysine methyltransferase 2A, Histone-lysine N-methyltransferase HRX, ALL1, HTRX</td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">External IDs</th><td colspan="3" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:96995">96995</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=4338">4338</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=KMT2A">KMT2A</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000118058">KMT2A - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_11.svg" class="mw-file-description" title="Chromosome 11 (human)"><img alt="Chromosome 11 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_human_chromosome_11.svg/300px-Ideogram_human_chromosome_11.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_human_chromosome_11.svg/450px-Ideogram_human_chromosome_11.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_human_chromosome_11.svg/600px-Ideogram_human_chromosome_11.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Chromosome_11_(human)" class="mw-redirect" title="Chromosome 11 (human)">Chromosome 11 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_11_ideogram.svg" class="mw-file-description" title="Chromosome 11 (human)"><img alt="Chromosome 11 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/43/Human_chromosome_11_ideogram.svg/300px-Human_chromosome_11_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/43/Human_chromosome_11_ideogram.svg/450px-Human_chromosome_11_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/43/Human_chromosome_11_ideogram.svg/600px-Human_chromosome_11_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 252.57806307556px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for KMT2A"><img alt="Genomic location for KMT2A" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 258.6px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for KMT2A"><img alt="Genomic location for KMT2A" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">11q23.3</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">118,436,456 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">118,526,832 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_9.svg" class="mw-file-description" title="Chromosome 9 (mouse)"><img alt="Chromosome 9 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/41/Ideogram_house_mouse_chromosome_9.svg/260px-Ideogram_house_mouse_chromosome_9.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/41/Ideogram_house_mouse_chromosome_9.svg/390px-Ideogram_house_mouse_chromosome_9.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/41/Ideogram_house_mouse_chromosome_9.svg/520px-Ideogram_house_mouse_chromosome_9.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">Chromosome 9 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_9.svg" class="mw-file-description" title="Chromosome 9 (mouse)"><img alt="Chromosome 9 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_9.svg/300px-Ideogram_of_house_mouse_chromosome_9.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_9.svg/450px-Ideogram_of_house_mouse_chromosome_9.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Ideogram_of_house_mouse_chromosome_9.svg/600px-Ideogram_of_house_mouse_chromosome_9.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 100.25042516182px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for KMT2A"><img alt="Genomic location for KMT2A" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 106.3px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for KMT2A"><img alt="Genomic location for KMT2A" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">9 A5.2|9 24.84 cM</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">44,714,652 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">44,792,594 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000118058">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">ventricular zone</li><br /><li style="line-height: 137%;">epithelium of colon</li><br /><li style="line-height: 137%;">sural nerve</li><br /><li style="line-height: 137%;">ganglionic eminence</li><br /><li style="line-height: 137%;">Achilles tendon</li><br /><li style="line-height: 137%;">Brodmann area 23</li><br /><li style="line-height: 137%;">bone marrow cells</li><br /><li style="line-height: 137%;">cerebellar vermis</li><br /><li style="line-height: 137%;">lateral nuclear group of thalamus</li><br /><li style="line-height: 137%;">external globus pallidus</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000002028">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">tail of embryo</li><br /><li style="line-height: 137%;">genital tubercle</li><br /><li style="line-height: 137%;">dorsomedial hypothalamic nucleus</li><br /><li style="line-height: 137%;">Rostral migratory stream</li><br /><li style="line-height: 137%;">CA3 field</li><br /><li style="line-height: 137%;">cingulate gyrus</li><br /><li style="line-height: 137%;">central gray substance of midbrain</li><br /><li style="line-height: 137%;">habenula</li><br /><li style="line-height: 137%;">neural layer of retina</li><br /><li style="line-height: 137%;">entorhinal cortex</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000118058">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_MLL_212076_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5c/PBB_GE_MLL_212076_at_fs.png/250px-PBB_GE_MLL_212076_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5c/PBB_GE_MLL_212076_at_fs.png/375px-PBB_GE_MLL_212076_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5c/PBB_GE_MLL_212076_at_fs.png/500px-PBB_GE_MLL_212076_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_MLL_212078_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/11/PBB_GE_MLL_212078_s_at_fs.png/250px-PBB_GE_MLL_212078_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/11/PBB_GE_MLL_212078_s_at_fs.png/375px-PBB_GE_MLL_212078_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/11/PBB_GE_MLL_212078_s_at_fs.png/500px-PBB_GE_MLL_212078_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_MLL_212080_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b4/PBB_GE_MLL_212080_at_fs.png/250px-PBB_GE_MLL_212080_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b4/PBB_GE_MLL_212080_at_fs.png/375px-PBB_GE_MLL_212080_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b4/PBB_GE_MLL_212080_at_fs.png/500px-PBB_GE_MLL_212080_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/4297/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Molecular function</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008168">methyltransferase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016740">transferase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003677">DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042803">protein homodimerization activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003680">minor groove of adenine-thymine-rich DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003700">DNA-binding transcription factor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008270">zinc ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003682">chromatin binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046872">metal ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001046">core promoter sequence-specific DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045322">unmethylated CpG binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070577">lysine-acetylated histone binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042802">identical protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0018024">histone-lysine N-methyltransferase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042800">histone methyltransferase activity (H3-K4 specific)</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000981">DNA-binding transcription factor activity, RNA polymerase II-specific</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000978">RNA polymerase II cis-regulatory region sequence-specific DNA binding</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Cellular component</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005654">nucleoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035097">histone methyltransferase complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071339">MLL1 complex</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Biological process</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008542">visual learning</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035864">response to potassium ion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006355">regulation of transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050890">cognition</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032411">positive regulation of transporter activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2001040">positive regulation of cellular response to drug</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009416">response to light stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048511">rhythmic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048172">regulation of short-term neuronal synaptic plasticity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0080182">histone H3-K4 trimethylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051899">membrane depolarization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051569">regulation of histone H3-K4 methylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2000615">regulation of histone H3-K9 acetylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006366">transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009791">post-embryonic development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0018026">peptidyl-lysine monomethylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048536">spleen development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032922">circadian regulation of gene expression</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071440">regulation of histone H3-K14 acetylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006351">transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1901674">regulation of histone H3-K27 acetylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045893">positive regulation of transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006306">DNA methylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051568">histone H3-K4 methylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032259">methylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051571">positive regulation of histone H3-K4 methylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035640">exploration behavior</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035162">embryonic hemopoiesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044648">histone H3-K4 dimethylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010468">regulation of gene expression</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048873">homeostasis of number of cells within a tissue</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043984">histone H4-K16 acetylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060216">definitive hemopoiesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009952">anterior/posterior pattern specification</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008285">negative regulation of cell population proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006915">apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045652">regulation of megakaryocyte differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1902036">regulation of hematopoietic stem cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006325">chromatin organization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045944">positive regulation of transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0065003">protein-containing complex assembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1905642">negative regulation of DNA methylation</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=4297&rn=1">4297</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=214162&rn=1">214162</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000118058;db=core">ENSG00000118058</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000002028;db=core">ENSMUSG00000002028</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q03164">Q03164</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P55200">P55200</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001197104">NM_001197104</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_005933">NM_005933</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_024891">NM_024891</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001081049">NM_001081049</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001357549">NM_001357549</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001184033">NP_001184033</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_005924">NP_005924</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001344478">NP_001344478</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr11:118436456-118526832">Chr 11: 118.44 – 118.53 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr9:44714652-44792594">Chr 9: 44.71 – 44.79 Mb</a></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18029164" class="extiw" title="d:Q18029164">View/Edit Human</a></td><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18296519" class="extiw" title="d:Q18296519">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Histone-lysine <i>N</i>-methyltransferase 2A</b>, also known as <b>acute lymphoblastic leukemia 1</b> (<b>ALL-1</b>), <b>myeloid/lymphoid or mixed-lineage leukemia</b> <b>1</b> (<b>MLL1</b>), or <b>zinc finger protein HRX</b> (<b>HRX</b>), is an <a href="/wiki/Enzyme" title="Enzyme">enzyme</a> that in humans is encoded by the <i><b>KMT2A</b></i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid1720549_5-0" class="reference"><a href="#cite_note-pmid1720549-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>MLL1 is a histone <a href="/wiki/Methyltransferase" title="Methyltransferase">methyltransferase</a> deemed a positive global regulator of <a href="/wiki/Gene_transcription" class="mw-redirect" title="Gene transcription">gene transcription</a>. This protein belongs to the group of <a href="/wiki/Histone-modifying_enzymes" title="Histone-modifying enzymes">histone-modifying enzymes</a> comprising <a href="/wiki/Transactivation" title="Transactivation">transactivation</a> domain 9aaTAD<sup id="cite_ref-9aaTAD_6-0" class="reference"><a href="#cite_note-9aaTAD-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> and is involved in the <a href="/wiki/Epigenetic" class="mw-redirect" title="Epigenetic">epigenetic</a> maintenance of transcriptional memory. Its role as an epigenetic regulator of neuronal function is an ongoing area of research. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=KMT2A&action=edit&section=1" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Transcriptional_regulation">Transcriptional regulation</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=KMT2A&action=edit&section=2" title="Edit section: Transcriptional regulation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>KMT2A gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and <a href="/wiki/Hematopoiesis" class="mw-redirect" title="Hematopoiesis">hematopoiesis</a>. The encoded protein contains multiple conserved functional domains. One of these domains, the <a href="/wiki/SET_domain" title="SET domain">SET domain</a>, is responsible for its <a href="/wiki/Histone_H3" title="Histone H3">histone H3</a> lysine 4 (H3K4) methyltransferase activity which mediates <a href="/wiki/Chromatin" title="Chromatin">chromatin</a> modifications associated with epigenetic transcriptional activation. Enriched in the nucleus, the MLL1 enzyme trimethylates H3K4 (<a href="/wiki/H3K4me3" title="H3K4me3">H3K4me3</a>). It also upregulates mono- and dimethylation of H3K4.<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> This protein is processed by the enzyme <a href="/wiki/TASP1" title="TASP1">Taspase 1</a> into two fragments, MLL-C (~180 kDa) and MLL-N (~320 kDa).<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> These fragments then assemble into different multi-protein complexes that regulate the transcription of specific target genes, including many of the <a href="/wiki/HOX_genes" class="mw-redirect" title="HOX genes">HOX genes</a>. </p><p>Transcriptome profiling after deletion of MLL1 in cortical neurons revealed decreased promoter-bound H3K4me3 peaks at 318 genes, with 31 of these having significantly decreased expression and promoter binding.<sup id="cite_ref-:0_10-0" class="reference"><a href="#cite_note-:0-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Among them were <i><a href="/wiki/MEIS2" title="MEIS2">Meis2</a></i>, a homeobox transcription factor critical for development of forebrain neurons<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> and <i><a href="/wiki/SATB2" title="SATB2">Satb2</a></i>, a protein involved in neuronal differentiation.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p><p>Multiple chromosomal translocations involving this gene are the cause of certain <a href="/wiki/Acute_lymphoid_leukemia" class="mw-redirect" title="Acute lymphoid leukemia">acute lymphoid leukemias</a> and <a href="/wiki/Acute_myeloid_leukemia" title="Acute myeloid leukemia">acute myeloid leukemias</a>. Alternate splicing results in multiple transcript variants.<sup id="cite_ref-entrez_14-0" class="reference"><a href="#cite_note-entrez-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Cognition_and_emotion">Cognition and emotion</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=KMT2A&action=edit&section=3" title="Edit section: Cognition and emotion"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>MLL1 has been shown to be an important epigenetic regulator of complex behaviors. Rodent models of MLL1 dysfunction in forebrain neurons showed that conditional deletion results in elevated anxiety and defective cognition. <a href="/wiki/Prefrontal_cortex" title="Prefrontal cortex">Prefrontal cortex</a>-specific knockout of MLL1 results in the same phenotypes, as well as working memory deficits.<sup id="cite_ref-:0_10-1" class="reference"><a href="#cite_note-:0-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Stem_cells">Stem cells</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=KMT2A&action=edit&section=4" title="Edit section: Stem cells"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>MLL1 has been found to be an important regulator of <a href="/wiki/Epiblast-derived_stem_cells" class="mw-redirect" title="Epiblast-derived stem cells">epiblast-derived stem cells</a>, post-implantation epiblast derived stem cells which display pluripotency yet many recognizable differences from the traditional <a href="/wiki/Embryonic_stem_cell" title="Embryonic stem cell">embryonic stem cells</a> derived from inner cell mass prior to implantation. Suppression of MLL1 expression was shown to be adequate for inducing ESC-like morphology and behavior within 72 hours of treatment. It has been proposed that the small molecule inhibitor MM-401, which was used to inhibit MLL1, changes the distribution of <a href="/wiki/H3K4me1" title="H3K4me1">H3K4me1</a>, the single <a href="/wiki/Methylation" title="Methylation">methylation</a> of the <a href="/wiki/Histone_H3" title="Histone H3">histone H3</a> lysine 4, to be significantly downregulated at MLL1 targets thus leading to decreased expression of MLL1 targets, rather than a direct regulation of pluripotency core markers.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=KMT2A&action=edit&section=5" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Gene">Gene</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=KMT2A&action=edit&section=6" title="Edit section: Gene"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>KMT2A gene has 37 <a href="/wiki/Exons" class="mw-redirect" title="Exons">exons</a> and resides on <a href="/wiki/Chromosome_11" title="Chromosome 11">chromosome 11</a> at q23.<sup id="cite_ref-entrez_14-1" class="reference"><a href="#cite_note-entrez-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Protein">Protein</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=KMT2A&action=edit&section=7" title="Edit section: Protein"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>KMT2A has over a dozen binding partners and is cleaved into two pieces, a larger <a href="/wiki/N-terminus" title="N-terminus">N-terminal fragment</a>, involved in gene repression, and a smaller <a href="/wiki/C-terminus" title="C-terminus">C-terminal fragment</a>, which is a transcriptional activator.<sup id="cite_ref-pmid_12393701_16-0" class="reference"><a href="#cite_note-pmid_12393701-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> The cleavage, followed by the association of the two fragments, is necessary for KMT2A to be fully active. Like many other <a href="/wiki/Methyltransferase" title="Methyltransferase">methyltransferases</a>, the KMT2 family members exist in multisubunit nuclear complexes (human COMPASS), where other subunits also mediate the enzymatic activity.<sup id="cite_ref-pmid_22500810_17-0" class="reference"><a href="#cite_note-pmid_22500810-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p><p><span class="mw-default-size" typeof="mw:File"><a href="/wiki/File:9aaTADs_in_the_E_protein_family.jpg" class="mw-file-description" title="9aaTADs in the E protein family"><img alt="9aaTADs in the E protein family" src="//upload.wikimedia.org/wikipedia/commons/9/97/9aaTADs_in_the_E_protein_family.jpg" decoding="async" width="600" height="533" class="mw-file-element" data-file-width="600" data-file-height="533" /></a></span> <span class="mw-default-size" typeof="mw:File"><a href="/wiki/File:Piskacek_Figures_v9b.jpg" class="mw-file-description" title="E2A and MLL binding to the KIX domain of CBP"><img alt="E2A and MLL binding to the KIX domain of CBP" src="//upload.wikimedia.org/wikipedia/commons/d/d0/Piskacek_Figures_v9b.jpg" decoding="async" width="550" height="498" class="mw-file-element" data-file-width="550" data-file-height="498" /></a></span> </p> <div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=KMT2A&action=edit&section=8" title="Edit section: Clinical significance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Abnormal H3K4 trimethylation has been implicated in several neurological disorders such as autism.<sup id="cite_ref-Shulha_HP_2011_18-0" class="reference"><a href="#cite_note-Shulha_HP_2011-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> Humans with cognitive and neurodevelopmental disease often have dysregulation of H3K4 methylation in <a href="/wiki/Prefrontal_cortex" title="Prefrontal cortex">prefrontal cortex</a> (PFC) neurons.<sup id="cite_ref-Shulha_HP_2011_18-1" class="reference"><a href="#cite_note-Shulha_HP_2011-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid17942719_19-0" class="reference"><a href="#cite_note-pmid17942719-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> It also may participate in the process of <a href="/wiki/GAD67" class="mw-redirect" title="GAD67">GAD67</a> downregulation in <a href="/wiki/Schizophrenia" title="Schizophrenia">schizophrenia</a>.<sup id="cite_ref-pmid17942719_19-1" class="reference"><a href="#cite_note-pmid17942719-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p><p>MLL1 is required for the expression of <a href="/wiki/Senescence-associated_secretory_phenotype" title="Senescence-associated secretory phenotype">senescence-associated secretory phenotype</a> (SASP)-related genes and promotes increased inflammation.<sup id="cite_ref-pmid27259204_21-0" class="reference"><a href="#cite_note-pmid27259204-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </p><p>Rearrangements of the MLL1 gene are associated with aggressive acute <a href="/wiki/Leukemia" title="Leukemia">leukemias</a>, both lymphoblastic and myeloid.<sup id="cite_ref-pmid15941828_22-0" class="reference"><a href="#cite_note-pmid15941828-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> Despite being an aggressive leukemia, the MLL1 rearranged sub-type had the lowest mutation rates reported for any cancer.<sup id="cite_ref-Andersson_2015_23-0" class="reference"><a href="#cite_note-Andersson_2015-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p><p>Mutations in MLL1 cause <a href="/wiki/Wiedemann-Steiner_syndrome" class="mw-redirect" title="Wiedemann-Steiner syndrome">Wiedemann-Steiner syndrome</a> and <a href="/wiki/Acute_lymphoblastic_leukemia" title="Acute lymphoblastic leukemia">acute lymphoblastic leukemia</a>.<sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> The leukemia cells of up to 80 percent of infants with ALL-1 have a chromosomal rearrangement that fuses the MLL1 gene to a gene on a different chromosome.<sup id="cite_ref-Andersson_2015_23-1" class="reference"><a href="#cite_note-Andersson_2015-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=KMT2A&action=edit&section=9" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>MLL (gene) has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with: </p> <style data-mw-deduplicate="TemplateStyles:r1184024115">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}</style><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/ASH2L" title="ASH2L">ASH2L</a>,<sup id="cite_ref-pmid15199122_25-0" class="reference"><a href="#cite_note-pmid15199122-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/CREB_binding_protein" class="mw-redirect" title="CREB binding protein">CREBBP</a>,<sup id="cite_ref-pmid12205094_26-0" class="reference"><a href="#cite_note-pmid12205094-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11259575_27-0" class="reference"><a href="#cite_note-pmid11259575-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/CTBP1" title="CTBP1">CTBP1</a>,<sup id="cite_ref-pmid12829790_28-0" class="reference"><a href="#cite_note-pmid12829790-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/HDAC1" title="HDAC1">HDAC1</a>,<sup id="cite_ref-pmid12829790_28-1" class="reference"><a href="#cite_note-pmid12829790-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Host_cell_factor_C1" title="Host cell factor C1">HCFC1</a>,<sup id="cite_ref-pmid15199122_25-1" class="reference"><a href="#cite_note-pmid15199122-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/MEN1" title="MEN1">MEN1</a>,<sup id="cite_ref-pmid15199122_25-2" class="reference"><a href="#cite_note-pmid15199122-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PPIE_(gene)" title="PPIE (gene)">PPIE</a>,<sup id="cite_ref-pmid11313484_29-0" class="reference"><a href="#cite_note-pmid11313484-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PPP1R15A" title="PPP1R15A">PPP1R15A</a>,<sup id="cite_ref-pmid10490642_30-0" class="reference"><a href="#cite_note-pmid10490642-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/RBBP5" title="RBBP5">RBBP5</a>,<sup id="cite_ref-pmid15199122_25-3" class="reference"><a href="#cite_note-pmid15199122-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> and</li> <li><a href="/wiki/WDR5" title="WDR5">WDR5</a>.<sup id="cite_ref-pmid15199122_25-4" class="reference"><a href="#cite_note-pmid15199122-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=KMT2A&action=edit&section=10" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 33em;"> <ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000118058">GRCh38: Ensembl release 89: ENSG00000118058</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000002028">GRCm38: Ensembl release 89: ENSMUSG00000002028</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=4297">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D4297&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=214162">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Mouse+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D214162&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-pmid1720549-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid1720549_5-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZiemin-van_der_PoelMcCabeGillEspinosa1991" class="citation journal cs1">Ziemin-van der Poel S, McCabe NR, Gill HJ, Espinosa R, Patel Y, Harden A, et al. (December 1991). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC53005">"Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>88</b> (23): <span class="nowrap">10735–</span>9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.88.23.10735">10.1073/pnas.88.23.10735</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC53005">53005</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1720549">1720549</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Identification+of+a+gene%2C+MLL%2C+that+spans+the+breakpoint+in+11q23+translocations+associated+with+human+leukemias&rft.volume=88&rft.issue=23&rft.pages=%3Cspan+class%3D%22nowrap%22%3E10735-%3C%2Fspan%3E9&rft.date=1991-12&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC53005%23id-name%3DPMC&rft_id=info%3Apmid%2F1720549&rft_id=info%3Adoi%2F10.1073%2Fpnas.88.23.10735&rft.aulast=Ziemin-van+der+Poel&rft.aufirst=S&rft.au=McCabe%2C+NR&rft.au=Gill%2C+HJ&rft.au=Espinosa%2C+R&rft.au=Patel%2C+Y&rft.au=Harden%2C+A&rft.au=Rubinelli%2C+P&rft.au=Smith%2C+SD&rft.au=LeBeau%2C+MM&rft.au=Rowley%2C+JD&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC53005&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-9aaTAD-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-9aaTAD_6-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGotoZorMartinez-YamoutDyson2002" class="citation journal cs1">Goto NK, Zor T, Martinez-Yamout M, <a href="/wiki/Jane_Dyson" title="Jane Dyson">Dyson HJ</a>, Wright PE (November 2002). <a rel="nofollow" class="external text" href="http://www.tau.ac.il/lifesci/departments/biochem/members/zor/pdfs/Zor_JBC_MLL_2002.pdf">"Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain"</a> <span class="cs1-format">(PDF)</span>. <i>The Journal of Biological Chemistry</i>. <b>277</b> (45): <span class="nowrap">43168–</span>74. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M207660200">10.1074/jbc.M207660200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12205094">12205094</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:30354764">30354764</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Cooperativity+in+transcription+factor+binding+to+the+coactivator+CREB-binding+protein+%28CBP%29.+The+mixed+lineage+leukemia+protein+%28MLL%29+activation+domain+binds+to+an+allosteric+site+on+the+KIX+domain&rft.volume=277&rft.issue=45&rft.pages=%3Cspan+class%3D%22nowrap%22%3E43168-%3C%2Fspan%3E74&rft.date=2002-11&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A30354764%23id-name%3DS2CID&rft_id=info%3Apmid%2F12205094&rft_id=info%3Adoi%2F10.1074%2Fjbc.M207660200&rft.aulast=Goto&rft.aufirst=NK&rft.au=Zor%2C+T&rft.au=Martinez-Yamout%2C+M&rft.au=Dyson%2C+HJ&rft.au=Wright%2C+PE&rft_id=http%3A%2F%2Fwww.tau.ac.il%2Flifesci%2Fdepartments%2Fbiochem%2Fmembers%2Fzor%2Fpdfs%2FZor_JBC_MLL_2002.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span>; <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFPrasadYanoSorioNakamura1995" class="citation journal cs1">Prasad R, Yano T, Sorio C, Nakamura T, Rallapalli R, Gu Y, et al. (December 1995). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC40316">"Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>92</b> (26): <span class="nowrap">12160–</span>4. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1995PNAS...9212160P">1995PNAS...9212160P</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.92.26.12160">10.1073/pnas.92.26.12160</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC40316">40316</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8618864">8618864</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Domains+with+transcriptional+regulatory+activity+within+the+ALL1+and+AF4+proteins+involved+in+acute+leukemia&rft.volume=92&rft.issue=26&rft.pages=%3Cspan+class%3D%22nowrap%22%3E12160-%3C%2Fspan%3E4&rft.date=1995-12&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC40316%23id-name%3DPMC&rft_id=info%3Apmid%2F8618864&rft_id=info%3Adoi%2F10.1073%2Fpnas.92.26.12160&rft_id=info%3Abibcode%2F1995PNAS...9212160P&rft.aulast=Prasad&rft.aufirst=R&rft.au=Yano%2C+T&rft.au=Sorio%2C+C&rft.au=Nakamura%2C+T&rft.au=Rallapalli%2C+R&rft.au=Gu%2C+Y&rft.au=Leshkowitz%2C+D&rft.au=Croce%2C+CM&rft.au=Canaani%2C+E&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC40316&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span>; <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFErnstWangHuangGoodman2001" class="citation journal cs1">Ernst P, Wang J, Huang M, Goodman RH, Korsmeyer SJ (April 2001). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC86859">"MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein"</a>. <i>Molecular and Cellular Biology</i>. <b>21</b> (7): <span class="nowrap">2249–</span>58. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2FMCB.21.7.2249-2258.2001">10.1128/MCB.21.7.2249-2258.2001</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC86859">86859</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11259575">11259575</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=MLL+and+CREB+bind+cooperatively+to+the+nuclear+coactivator+CREB-binding+protein&rft.volume=21&rft.issue=7&rft.pages=%3Cspan+class%3D%22nowrap%22%3E2249-%3C%2Fspan%3E58&rft.date=2001-04&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC86859%23id-name%3DPMC&rft_id=info%3Apmid%2F11259575&rft_id=info%3Adoi%2F10.1128%2FMCB.21.7.2249-2258.2001&rft.aulast=Ernst&rft.aufirst=P&rft.au=Wang%2C+J&rft.au=Huang%2C+M&rft.au=Goodman%2C+RH&rft.au=Korsmeyer%2C+SJ&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC86859&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-7">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDel_RizzoTrievel2011" class="citation journal cs1">Del Rizzo PA, Trievel RC (September 2011). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225744">"Substrate and product specificities of SET domain methyltransferases"</a>. <i>Epigenetics</i>. <b>6</b> (9): <span class="nowrap">1059–</span>67. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.4161%2Fepi.6.9.16069">10.4161/epi.6.9.16069</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225744">3225744</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21847010">21847010</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Epigenetics&rft.atitle=Substrate+and+product+specificities+of+SET+domain+methyltransferases&rft.volume=6&rft.issue=9&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1059-%3C%2Fspan%3E67&rft.date=2011-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3225744%23id-name%3DPMC&rft_id=info%3Apmid%2F21847010&rft_id=info%3Adoi%2F10.4161%2Fepi.6.9.16069&rft.aulast=Del+Rizzo&rft.aufirst=PA&rft.au=Trievel%2C+RC&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3225744&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-8">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTakedaChenWestergardFisher2006" class="citation journal cs1">Takeda S, Chen DY, Westergard TD, Fisher JK, Rubens JA, Sasagawa S, et al. (September 2006). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560414">"Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression"</a>. <i>Genes & Development</i>. <b>20</b> (17): <span class="nowrap">2397–</span>409. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgad.1449406">10.1101/gad.1449406</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560414">1560414</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16951254">16951254</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genes+%26+Development&rft.atitle=Proteolysis+of+MLL+family+proteins+is+essential+for+taspase1-orchestrated+cell+cycle+progression&rft.volume=20&rft.issue=17&rft.pages=%3Cspan+class%3D%22nowrap%22%3E2397-%3C%2Fspan%3E409&rft.date=2006-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1560414%23id-name%3DPMC&rft_id=info%3Apmid%2F16951254&rft_id=info%3Adoi%2F10.1101%2Fgad.1449406&rft.aulast=Takeda&rft.aufirst=S&rft.au=Chen%2C+DY&rft.au=Westergard%2C+TD&rft.au=Fisher%2C+JK&rft.au=Rubens%2C+JA&rft.au=Sasagawa%2C+S&rft.au=Kan%2C+JT&rft.au=Korsmeyer%2C+SJ&rft.au=Cheng%2C+EH&rft.au=Hsieh%2C+JJ&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1560414&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-9">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHsiehErnstErdjument-BromageTempst2003" class="citation journal cs1">Hsieh JJ, Ernst P, Erdjument-Bromage H, Tempst P, Korsmeyer SJ (January 2003). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC140678">"Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization"</a>. <i>Molecular and Cellular Biology</i>. <b>23</b> (1): <span class="nowrap">186–</span>94. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2FMCB.23.1.186-194.2003">10.1128/MCB.23.1.186-194.2003</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC140678">140678</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12482972">12482972</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=Proteolytic+cleavage+of+MLL+generates+a+complex+of+N-+and+C-terminal+fragments+that+confers+protein+stability+and+subnuclear+localization&rft.volume=23&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E186-%3C%2Fspan%3E94&rft.date=2003-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC140678%23id-name%3DPMC&rft_id=info%3Apmid%2F12482972&rft_id=info%3Adoi%2F10.1128%2FMCB.23.1.186-194.2003&rft.aulast=Hsieh&rft.aufirst=JJ&rft.au=Ernst%2C+P&rft.au=Erdjument-Bromage%2C+H&rft.au=Tempst%2C+P&rft.au=Korsmeyer%2C+SJ&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC140678&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-:0-10"><span class="mw-cite-backlink">^ <a href="#cite_ref-:0_10-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:0_10-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFJakovcevskiRuanShenDincer2015" class="citation journal cs1">Jakovcevski M, Ruan H, Shen EY, Dincer A, Javidfar B, Ma Q, et al. (April 2015). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380991">"Neuronal Kmt2a/Mll1 histone methyltransferase is essential for prefrontal synaptic plasticity and working memory"</a>. <i>The Journal of Neuroscience</i>. <b>35</b> (13): <span class="nowrap">5097–</span>108. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1523%2FJNEUROSCI.3004-14.2015">10.1523/JNEUROSCI.3004-14.2015</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380991">4380991</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25834037">25834037</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Neuroscience&rft.atitle=Neuronal+Kmt2a%2FMll1+histone+methyltransferase+is+essential+for+prefrontal+synaptic+plasticity+and+working+memory&rft.volume=35&rft.issue=13&rft.pages=%3Cspan+class%3D%22nowrap%22%3E5097-%3C%2Fspan%3E108&rft.date=2015-04&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4380991%23id-name%3DPMC&rft_id=info%3Apmid%2F25834037&rft_id=info%3Adoi%2F10.1523%2FJNEUROSCI.3004-14.2015&rft.aulast=Jakovcevski&rft.aufirst=M&rft.au=Ruan%2C+H&rft.au=Shen%2C+EY&rft.au=Dincer%2C+A&rft.au=Javidfar%2C+B&rft.au=Ma%2C+Q&rft.au=Peter%2C+CJ&rft.au=Cheung%2C+I&rft.au=Mitchell%2C+AC&rft.au=Jiang%2C+Y&rft.au=Lin%2C+CL&rft.au=Pothula%2C+V&rft.au=Stewart%2C+AF&rft.au=Ernst%2C+P&rft.au=Yao%2C+WD&rft.au=Akbarian%2C+S&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4380991&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-11">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTakahashiLiuOishiMori2008" class="citation journal cs1">Takahashi K, Liu FC, Oishi T, Mori T, Higo N, Hayashi M, et al. (July 2008). "Expression of FOXP2 in the developing monkey forebrain: comparison with the expression of the genes FOXP1, PBX3, and MEIS2". <i>The Journal of Comparative Neurology</i>. <b>509</b> (2): <span class="nowrap">180–</span>9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fcne.21740">10.1002/cne.21740</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18461604">18461604</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:5166430">5166430</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Comparative+Neurology&rft.atitle=Expression+of+FOXP2+in+the+developing+monkey+forebrain%3A+comparison+with+the+expression+of+the+genes+FOXP1%2C+PBX3%2C+and+MEIS2&rft.volume=509&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E180-%3C%2Fspan%3E9&rft.date=2008-07&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A5166430%23id-name%3DS2CID&rft_id=info%3Apmid%2F18461604&rft_id=info%3Adoi%2F10.1002%2Fcne.21740&rft.aulast=Takahashi&rft.aufirst=K&rft.au=Liu%2C+FC&rft.au=Oishi%2C+T&rft.au=Mori%2C+T&rft.au=Higo%2C+N&rft.au=Hayashi%2C+M&rft.au=Hirokawa%2C+K&rft.au=Takahashi%2C+H&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-12">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLarsenLutterodtLaursenGraem2010" class="citation journal cs1">Larsen KB, Lutterodt MC, Laursen H, Graem N, Pakkenberg B, Møllgård K, et al. (July 2010). "Spatiotemporal distribution of PAX6 and MEIS2 expression and total cell numbers in the ganglionic eminence in the early developing human forebrain". <i>Developmental Neuroscience</i>. <b>32</b> (2): <span class="nowrap">149–</span>62. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1159%2F000297602">10.1159/000297602</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20523026">20523026</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:21973035">21973035</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Developmental+Neuroscience&rft.atitle=Spatiotemporal+distribution+of+PAX6+and+MEIS2+expression+and+total+cell+numbers+in+the+ganglionic+eminence+in+the+early+developing+human+forebrain&rft.volume=32&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E149-%3C%2Fspan%3E62&rft.date=2010-07&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A21973035%23id-name%3DS2CID&rft_id=info%3Apmid%2F20523026&rft_id=info%3Adoi%2F10.1159%2F000297602&rft.aulast=Larsen&rft.aufirst=KB&rft.au=Lutterodt%2C+MC&rft.au=Laursen%2C+H&rft.au=Graem%2C+N&rft.au=Pakkenberg%2C+B&rft.au=M%C3%B8llg%C3%A5rd%2C+K&rft.au=M%C3%B8ller%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-13">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBritanovade_Juan_RomeroCheungKwan2008" class="citation journal cs1">Britanova O, de Juan Romero C, Cheung A, Kwan KY, Schwark M, Gyorgy A, et al. (February 2008). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.neuron.2007.12.028">"Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex"</a>. <i>Neuron</i>. <b>57</b> (3): <span class="nowrap">378–</span>92. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.neuron.2007.12.028">10.1016/j.neuron.2007.12.028</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18255031">18255031</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:9248058">9248058</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=Satb2+is+a+postmitotic+determinant+for+upper-layer+neuron+specification+in+the+neocortex&rft.volume=57&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E378-%3C%2Fspan%3E92&rft.date=2008-02&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A9248058%23id-name%3DS2CID&rft_id=info%3Apmid%2F18255031&rft_id=info%3Adoi%2F10.1016%2Fj.neuron.2007.12.028&rft.aulast=Britanova&rft.aufirst=O&rft.au=de+Juan+Romero%2C+C&rft.au=Cheung%2C+A&rft.au=Kwan%2C+KY&rft.au=Schwark%2C+M&rft.au=Gyorgy%2C+A&rft.au=Vogel%2C+T&rft.au=Akopov%2C+S&rft.au=Mitkovski%2C+M&rft.au=Agoston%2C+D&rft.au=Sestan%2C+N&rft.au=Moln%C3%A1r%2C+Z&rft.au=Tarabykin%2C+V&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.neuron.2007.12.028&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-entrez-14"><span class="mw-cite-backlink">^ <a href="#cite_ref-entrez_14-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-entrez_14-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene/4297">"Entrez Gene: KMT2A lysine (K)-specific methyltransferase 2A"</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Entrez+Gene%3A+KMT2A+lysine+%28K%29-specific+methyltransferase+2A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgene%2F4297&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-15"><span class="mw-cite-backlink"><b><a href="#cite_ref-15">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZhangGayenXiongZhou2016" class="citation journal cs1">Zhang H, Gayen S, Xiong J, Zhou B, Shanmugam AK, Sun Y, et al. (2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826731">"MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency"</a>. <i>Cell Stem Cell</i>. <b>18</b> (4): <span class="nowrap">481–</span>94. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.stem.2016.02.004">10.1016/j.stem.2016.02.004</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826731">4826731</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26996599">26996599</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell+Stem+Cell&rft.atitle=MLL1+Inhibition+Reprograms+Epiblast+Stem+Cells+to+Naive+Pluripotency&rft.volume=18&rft.issue=4&rft.pages=%3Cspan+class%3D%22nowrap%22%3E481-%3C%2Fspan%3E94&rft.date=2016&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4826731%23id-name%3DPMC&rft_id=info%3Apmid%2F26996599&rft_id=info%3Adoi%2F10.1016%2Fj.stem.2016.02.004&rft.aulast=Zhang&rft.aufirst=H&rft.au=Gayen%2C+S&rft.au=Xiong%2C+J&rft.au=Zhou%2C+B&rft.au=Shanmugam%2C+AK&rft.au=Sun%2C+Y&rft.au=Karatas%2C+H&rft.au=Liu%2C+L&rft.au=Rao%2C+RC&rft.au=Wang%2C+S&rft.au=Nesvizhskii%2C+AI&rft.au=Kalantry%2C+S&rft.au=Dou%2C+Y&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4826731&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-pmid_12393701-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid_12393701_16-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFYokoyamaKitabayashiAytonCleary2002" class="citation journal cs1">Yokoyama A, Kitabayashi I, Ayton PM, Cleary ML, Ohki M (November 2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood-2002-04-1015">"Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties"</a>. <i>Blood</i>. <b>100</b> (10): <span class="nowrap">3710–</span>8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1182%2Fblood-2002-04-1015">10.1182/blood-2002-04-1015</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12393701">12393701</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Leukemia+proto-oncoprotein+MLL+is+proteolytically+processed+into+2+fragments+with+opposite+transcriptional+properties&rft.volume=100&rft.issue=10&rft.pages=%3Cspan+class%3D%22nowrap%22%3E3710-%3C%2Fspan%3E8&rft.date=2002-11&rft_id=info%3Adoi%2F10.1182%2Fblood-2002-04-1015&rft_id=info%3Apmid%2F12393701&rft.aulast=Yokoyama&rft.aufirst=A&rft.au=Kitabayashi%2C+I&rft.au=Ayton%2C+PM&rft.au=Cleary%2C+ML&rft.au=Ohki%2C+M&rft_id=https%3A%2F%2Fdoi.org%2F10.1182%252Fblood-2002-04-1015&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-pmid_22500810-17"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid_22500810_17-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMohanHerzShilatifard2012" class="citation journal cs1">Mohan M, Herz HM, Shilatifard A (April 2012). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711870">"SnapShot: Histone lysine methylase complexes"</a>. <i>Cell</i>. <b>149</b> (2): 498–498.e1. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.cell.2012.03.025">10.1016/j.cell.2012.03.025</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711870">3711870</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22500810">22500810</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=SnapShot%3A+Histone+lysine+methylase+complexes&rft.volume=149&rft.issue=2&rft.pages=498-498.e1&rft.date=2012-04&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3711870%23id-name%3DPMC&rft_id=info%3Apmid%2F22500810&rft_id=info%3Adoi%2F10.1016%2Fj.cell.2012.03.025&rft.aulast=Mohan&rft.aufirst=M&rft.au=Herz%2C+HM&rft.au=Shilatifard%2C+A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3711870&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-Shulha_HP_2011-18"><span class="mw-cite-backlink">^ <a href="#cite_ref-Shulha_HP_2011_18-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Shulha_HP_2011_18-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFShulhaCheungWhittleWang2012" class="citation journal cs1">Shulha HP, Cheung I, Whittle C, Wang J, Virgil D, Lin CL, et al. (March 2012). "Epigenetic signatures of autism: trimethylated H3K4 landscapes in prefrontal neurons". <i>Archives of General Psychiatry</i>. <b>69</b> (3): <span class="nowrap">314–</span>24. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1001%2Farchgenpsychiatry.2011.151">10.1001/archgenpsychiatry.2011.151</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22065254">22065254</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Archives+of+General+Psychiatry&rft.atitle=Epigenetic+signatures+of+autism%3A+trimethylated+H3K4+landscapes+in+prefrontal+neurons&rft.volume=69&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E314-%3C%2Fspan%3E24&rft.date=2012-03&rft_id=info%3Adoi%2F10.1001%2Farchgenpsychiatry.2011.151&rft_id=info%3Apmid%2F22065254&rft.aulast=Shulha&rft.aufirst=HP&rft.au=Cheung%2C+I&rft.au=Whittle%2C+C&rft.au=Wang%2C+J&rft.au=Virgil%2C+D&rft.au=Lin%2C+CL&rft.au=Guo%2C+Y&rft.au=Lessard%2C+A&rft.au=Akbarian%2C+S&rft.au=Weng%2C+Z&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-pmid17942719-19"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid17942719_19-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid17942719_19-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHuangMatevossianWhittleKim2007" class="citation journal cs1">Huang HS, Matevossian A, Whittle C, Kim SY, Schumacher A, Baker SP, et al. (October 2007). <a rel="nofollow" class="external text" href="https://escholarship.umassmed.edu/infoservices/34">"Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters"</a>. <i>The Journal of Neuroscience</i>. <b>27</b> (42): <span class="nowrap">11254–</span>62. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1523%2FJNEUROSCI.3272-07.2007">10.1523/JNEUROSCI.3272-07.2007</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673022">6673022</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17942719">17942719</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Neuroscience&rft.atitle=Prefrontal+dysfunction+in+schizophrenia+involves+mixed-lineage+leukemia+1-regulated+histone+methylation+at+GABAergic+gene+promoters&rft.volume=27&rft.issue=42&rft.pages=%3Cspan+class%3D%22nowrap%22%3E11254-%3C%2Fspan%3E62&rft.date=2007-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6673022%23id-name%3DPMC&rft_id=info%3Apmid%2F17942719&rft_id=info%3Adoi%2F10.1523%2FJNEUROSCI.3272-07.2007&rft.aulast=Huang&rft.aufirst=HS&rft.au=Matevossian%2C+A&rft.au=Whittle%2C+C&rft.au=Kim%2C+SY&rft.au=Schumacher%2C+A&rft.au=Baker%2C+SP&rft.au=Akbarian%2C+S&rft_id=https%3A%2F%2Fescholarship.umassmed.edu%2Finfoservices%2F34&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-20"><span class="mw-cite-backlink"><b><a href="#cite_ref-20">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFShenShulhaWengAkbarian2014" class="citation journal cs1">Shen E, Shulha H, Weng Z, Akbarian S (September 2014). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142035">"Regulation of histone H3K4 methylation in brain development and disease"</a>. <i>Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences</i>. <b>369</b> (1652): 20130514. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1098%2Frstb.2013.0514">10.1098/rstb.2013.0514</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142035">4142035</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25135975">25135975</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Philosophical+Transactions+of+the+Royal+Society+of+London.+Series+B%2C+Biological+Sciences&rft.atitle=Regulation+of+histone+H3K4+methylation+in+brain+development+and+disease&rft.volume=369&rft.issue=1652&rft.pages=20130514&rft.date=2014-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4142035%23id-name%3DPMC&rft_id=info%3Apmid%2F25135975&rft_id=info%3Adoi%2F10.1098%2Frstb.2013.0514&rft.aulast=Shen&rft.aufirst=E&rft.au=Shulha%2C+H&rft.au=Weng%2C+Z&rft.au=Akbarian%2C+S&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4142035&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-pmid27259204-21"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid27259204_21-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBoothBrunet2016" class="citation journal cs1">Booth LN, Brunet A (2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917370">"The Aging Epigenome"</a>. <i><a href="/wiki/Molecular_Cell" title="Molecular Cell">Molecular Cell</a></i>. <b>62</b> (5): <span class="nowrap">728–</span>744. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.molcel.2016.05.013">10.1016/j.molcel.2016.05.013</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917370">4917370</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27259204">27259204</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+Cell&rft.atitle=The+Aging+Epigenome&rft.volume=62&rft.issue=5&rft.pages=%3Cspan+class%3D%22nowrap%22%3E728-%3C%2Fspan%3E744&rft.date=2016&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4917370%23id-name%3DPMC&rft_id=info%3Apmid%2F27259204&rft_id=info%3Adoi%2F10.1016%2Fj.molcel.2016.05.013&rft.aulast=Booth&rft.aufirst=LN&rft.au=Brunet%2C+A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4917370&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-pmid15941828-22"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid15941828_22-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGuentherJennerChevalierNakamura2005" class="citation journal cs1">Guenther MG, Jenner RG, Chevalier B, Nakamura T, Croce CM, Canaani E, et al. (June 2005). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1150839">"Global and Hox-specific roles for the MLL1 methyltransferase"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>102</b> (24): <span class="nowrap">8603–</span>8. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2005PNAS..102.8603G">2005PNAS..102.8603G</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.0503072102">10.1073/pnas.0503072102</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1150839">1150839</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15941828">15941828</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Global+and+Hox-specific+roles+for+the+MLL1+methyltransferase&rft.volume=102&rft.issue=24&rft.pages=%3Cspan+class%3D%22nowrap%22%3E8603-%3C%2Fspan%3E8&rft.date=2005-06&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1150839%23id-name%3DPMC&rft_id=info%3Apmid%2F15941828&rft_id=info%3Adoi%2F10.1073%2Fpnas.0503072102&rft_id=info%3Abibcode%2F2005PNAS..102.8603G&rft.aulast=Guenther&rft.aufirst=MG&rft.au=Jenner%2C+RG&rft.au=Chevalier%2C+B&rft.au=Nakamura%2C+T&rft.au=Croce%2C+CM&rft.au=Canaani%2C+E&rft.au=Young%2C+RA&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1150839&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-Andersson_2015-23"><span class="mw-cite-backlink">^ <a href="#cite_ref-Andersson_2015_23-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Andersson_2015_23-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAnderssonMaWangChen2015" class="citation journal cs1">Andersson AK, Ma J, Wang J, Chen X, Gedman AL, Dang J, et al. (April 2015). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553269">"The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias"</a>. <i>Nature Genetics</i>. <b>47</b> (4): <span class="nowrap">330–</span>7. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fng.3230">10.1038/ng.3230</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553269">4553269</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25730765">25730765</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature+Genetics&rft.atitle=The+landscape+of+somatic+mutations+in+infant+MLL-rearranged+acute+lymphoblastic+leukemias&rft.volume=47&rft.issue=4&rft.pages=%3Cspan+class%3D%22nowrap%22%3E330-%3C%2Fspan%3E7&rft.date=2015-04&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4553269%23id-name%3DPMC&rft_id=info%3Apmid%2F25730765&rft_id=info%3Adoi%2F10.1038%2Fng.3230&rft.aulast=Andersson&rft.aufirst=AK&rft.au=Ma%2C+J&rft.au=Wang%2C+J&rft.au=Chen%2C+X&rft.au=Gedman%2C+AL&rft.au=Dang%2C+J&rft.au=Nakitandwe%2C+J&rft.au=Holmfeldt%2C+L&rft.au=Parker%2C+M&rft.au=Easton%2C+J&rft.au=Huether%2C+R&rft.au=Kriwacki%2C+R&rft.au=Rusch%2C+M&rft.au=Wu%2C+G&rft.au=Li%2C+Y&rft.au=Mulder%2C+H&rft.au=Raimondi%2C+S&rft.au=Pounds%2C+S&rft.au=Kang%2C+G&rft.au=Shi%2C+L&rft.au=Becksfort%2C+J&rft.au=Gupta%2C+P&rft.au=Payne-Turner%2C+D&rft.au=Vadodaria%2C+B&rft.au=Boggs%2C+K&rft.au=Yergeau%2C+D&rft.au=Manne%2C+J&rft.au=Song%2C+G&rft.au=Edmonson%2C+M&rft.au=Nagahawatte%2C+P&rft.au=Wei%2C+L&rft.au=Cheng%2C+C&rft.au=Pei%2C+D&rft.au=Sutton%2C+R&rft.au=Venn%2C+NC&rft.au=Chetcuti%2C+A&rft.au=Rush%2C+A&rft.au=Catchpoole%2C+D&rft.au=Heldrup%2C+J&rft.au=Fioretos%2C+T&rft.au=Lu%2C+C&rft.au=Ding%2C+L&rft.au=Pui%2C+CH&rft.au=Shurtleff%2C+S&rft.au=Mullighan%2C+CG&rft.au=Mardis%2C+ER&rft.au=Wilson%2C+RK&rft.au=Gruber%2C+TA&rft.au=Zhang%2C+J&rft.au=Downing%2C+JR&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4553269&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-24"><span class="mw-cite-backlink"><b><a href="#cite_ref-24">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMendelsohnPronoldLongSmaoui2014" class="citation journal cs1">Mendelsohn BA, Pronold M, Long R, Smaoui N, Slavotinek AM (August 2014). "Advanced bone age in a girl with Wiedemann-Steiner syndrome and an exonic deletion in KMT2A (MLL)". <i>American Journal of Medical Genetics. Part A</i>. <b>164A</b> (8): <span class="nowrap">2079–</span>83. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fajmg.a.36590">10.1002/ajmg.a.36590</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24818805">24818805</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:20957397">20957397</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=American+Journal+of+Medical+Genetics.+Part+A&rft.atitle=Advanced+bone+age+in+a+girl+with+Wiedemann-Steiner+syndrome+and+an+exonic+deletion+in+KMT2A+%28MLL%29&rft.volume=164A&rft.issue=8&rft.pages=%3Cspan+class%3D%22nowrap%22%3E2079-%3C%2Fspan%3E83&rft.date=2014-08&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A20957397%23id-name%3DS2CID&rft_id=info%3Apmid%2F24818805&rft_id=info%3Adoi%2F10.1002%2Fajmg.a.36590&rft.aulast=Mendelsohn&rft.aufirst=BA&rft.au=Pronold%2C+M&rft.au=Long%2C+R&rft.au=Smaoui%2C+N&rft.au=Slavotinek%2C+AM&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-pmid15199122-25"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid15199122_25-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid15199122_25-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid15199122_25-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-pmid15199122_25-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-pmid15199122_25-4"><sup><i><b>e</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFYokoyamaWangWysockaSanyal2004" class="citation journal cs1">Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, et al. (July 2004). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC480881">"Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression"</a>. <i>Molecular and Cellular Biology</i>. <b>24</b> (13): <span class="nowrap">5639–</span>49. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2FMCB.24.13.5639-5649.2004">10.1128/MCB.24.13.5639-5649.2004</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC480881">480881</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15199122">15199122</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=Leukemia+proto-oncoprotein+MLL+forms+a+SET1-like+histone+methyltransferase+complex+with+menin+to+regulate+Hox+gene+expression&rft.volume=24&rft.issue=13&rft.pages=%3Cspan+class%3D%22nowrap%22%3E5639-%3C%2Fspan%3E49&rft.date=2004-07&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC480881%23id-name%3DPMC&rft_id=info%3Apmid%2F15199122&rft_id=info%3Adoi%2F10.1128%2FMCB.24.13.5639-5649.2004&rft.aulast=Yokoyama&rft.aufirst=A&rft.au=Wang%2C+Z&rft.au=Wysocka%2C+J&rft.au=Sanyal%2C+M&rft.au=Aufiero%2C+DJ&rft.au=Kitabayashi%2C+I&rft.au=Herr%2C+W&rft.au=Cleary%2C+ML&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC480881&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-pmid12205094-26"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid12205094_26-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGotoZorMartinez-YamoutDyson2002" class="citation journal cs1">Goto NK, Zor T, Martinez-Yamout M, Dyson HJ, Wright PE (November 2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M207660200">"Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain"</a>. <i>The Journal of Biological Chemistry</i>. <b>277</b> (45): <span class="nowrap">43168–</span>74. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M207660200">10.1074/jbc.M207660200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12205094">12205094</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Cooperativity+in+transcription+factor+binding+to+the+coactivator+CREB-binding+protein+%28CBP%29.+The+mixed+lineage+leukemia+protein+%28MLL%29+activation+domain+binds+to+an+allosteric+site+on+the+KIX+domain&rft.volume=277&rft.issue=45&rft.pages=%3Cspan+class%3D%22nowrap%22%3E43168-%3C%2Fspan%3E74&rft.date=2002-11&rft_id=info%3Adoi%2F10.1074%2Fjbc.M207660200&rft_id=info%3Apmid%2F12205094&rft.aulast=Goto&rft.aufirst=NK&rft.au=Zor%2C+T&rft.au=Martinez-Yamout%2C+M&rft.au=Dyson%2C+HJ&rft.au=Wright%2C+PE&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M207660200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-pmid11259575-27"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11259575_27-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFErnstWangHuangGoodman2001" class="citation journal cs1">Ernst P, Wang J, Huang M, Goodman RH, Korsmeyer SJ (April 2001). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC86859">"MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein"</a>. <i>Molecular and Cellular Biology</i>. <b>21</b> (7): <span class="nowrap">2249–</span>58. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2FMCB.21.7.2249-2258.2001">10.1128/MCB.21.7.2249-2258.2001</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC86859">86859</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11259575">11259575</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=MLL+and+CREB+bind+cooperatively+to+the+nuclear+coactivator+CREB-binding+protein&rft.volume=21&rft.issue=7&rft.pages=%3Cspan+class%3D%22nowrap%22%3E2249-%3C%2Fspan%3E58&rft.date=2001-04&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC86859%23id-name%3DPMC&rft_id=info%3Apmid%2F11259575&rft_id=info%3Adoi%2F10.1128%2FMCB.21.7.2249-2258.2001&rft.aulast=Ernst&rft.aufirst=P&rft.au=Wang%2C+J&rft.au=Huang%2C+M&rft.au=Goodman%2C+RH&rft.au=Korsmeyer%2C+SJ&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC86859&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-pmid12829790-28"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid12829790_28-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid12829790_28-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFXiaAndersonDiazZeleznik-Le2003" class="citation journal cs1">Xia ZB, Anderson M, Diaz MO, Zeleznik-Le NJ (July 2003). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC166231">"MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>100</b> (14): <span class="nowrap">8342–</span>7. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2003PNAS..100.8342X">2003PNAS..100.8342X</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.1436338100">10.1073/pnas.1436338100</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC166231">166231</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12829790">12829790</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=MLL+repression+domain+interacts+with+histone+deacetylases%2C+the+polycomb+group+proteins+HPC2+and+BMI-1%2C+and+the+corepressor+C-terminal-binding+protein&rft.volume=100&rft.issue=14&rft.pages=%3Cspan+class%3D%22nowrap%22%3E8342-%3C%2Fspan%3E7&rft.date=2003-07&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC166231%23id-name%3DPMC&rft_id=info%3Apmid%2F12829790&rft_id=info%3Adoi%2F10.1073%2Fpnas.1436338100&rft_id=info%3Abibcode%2F2003PNAS..100.8342X&rft.aulast=Xia&rft.aufirst=ZB&rft.au=Anderson%2C+M&rft.au=Diaz%2C+MO&rft.au=Zeleznik-Le%2C+NJ&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC166231&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-pmid11313484-29"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11313484_29-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFairAndersonBulanovaMi2001" class="citation journal cs1">Fair K, Anderson M, Bulanova E, Mi H, Tropschug M, Diaz MO (May 2001). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC100280">"Protein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells"</a>. <i>Molecular and Cellular Biology</i>. <b>21</b> (10): <span class="nowrap">3589–</span>97. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2FMCB.21.10.3589-3597.2001">10.1128/MCB.21.10.3589-3597.2001</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC100280">100280</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11313484">11313484</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=Protein+interactions+of+the+MLL+PHD+fingers+modulate+MLL+target+gene+regulation+in+human+cells&rft.volume=21&rft.issue=10&rft.pages=%3Cspan+class%3D%22nowrap%22%3E3589-%3C%2Fspan%3E97&rft.date=2001-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC100280%23id-name%3DPMC&rft_id=info%3Apmid%2F11313484&rft_id=info%3Adoi%2F10.1128%2FMCB.21.10.3589-3597.2001&rft.aulast=Fair&rft.aufirst=K&rft.au=Anderson%2C+M&rft.au=Bulanova%2C+E&rft.au=Mi%2C+H&rft.au=Tropschug%2C+M&rft.au=Diaz%2C+MO&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC100280&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> <li id="cite_note-pmid10490642-30"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid10490642_30-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAdlerChineryWuKussick1999" class="citation journal cs1">Adler HT, Chinery R, Wu DY, Kussick SJ, Payne JM, Fornace AJ, et al. (October 1999). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84700">"Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins"</a>. <i>Molecular and Cellular Biology</i>. <b>19</b> (10): <span class="nowrap">7050–</span>60. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2Fmcb.19.10.7050">10.1128/mcb.19.10.7050</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84700">84700</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10490642">10490642</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=Leukemic+HRX+fusion+proteins+inhibit+GADD34-induced+apoptosis+and+associate+with+the+GADD34+and+hSNF5%2FINI1+proteins&rft.volume=19&rft.issue=10&rft.pages=%3Cspan+class%3D%22nowrap%22%3E7050-%3C%2Fspan%3E60&rft.date=1999-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC84700%23id-name%3DPMC&rft_id=info%3Apmid%2F10490642&rft_id=info%3Adoi%2F10.1128%2Fmcb.19.10.7050&rft.aulast=Adler&rft.aufirst=HT&rft.au=Chinery%2C+R&rft.au=Wu%2C+DY&rft.au=Kussick%2C+SJ&rft.au=Payne%2C+JM&rft.au=Fornace%2C+AJ&rft.au=Tkachuk%2C+DC&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC84700&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=KMT2A&action=edit&section=11" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 33em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMarschalekNilsonLöchnerGreim1997" class="citation journal cs1">Marschalek R, Nilson I, Löchner K, Greim R, Siegler G, Greil J, et al. (November 1997). "The structure of the human ALL-1/MLL/HRX gene". <i>Leukemia & Lymphoma</i>. <b>27</b> (<span class="nowrap">5–</span>6): <span class="nowrap">417–</span>28. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3109%2F10428199709058308">10.3109/10428199709058308</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9477123">9477123</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Leukemia+%26+Lymphoma&rft.atitle=The+structure+of+the+human+ALL-1%2FMLL%2FHRX+gene&rft.volume=27&rft.issue=%3Cspan+class%3D%22nowrap%22%3E5%E2%80%93%3C%2Fspan%3E6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E417-%3C%2Fspan%3E28&rft.date=1997-11&rft_id=info%3Adoi%2F10.3109%2F10428199709058308&rft_id=info%3Apmid%2F9477123&rft.aulast=Marschalek&rft.aufirst=R&rft.au=Nilson%2C+I&rft.au=L%C3%B6chner%2C+K&rft.au=Greim%2C+R&rft.au=Siegler%2C+G&rft.au=Greil%2C+J&rft.au=Beck%2C+JD&rft.au=Fey%2C+GH&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFEguchiEguchi-IshimaeGreaves2003" class="citation journal cs1">Eguchi M, Eguchi-Ishimae M, Greaves M (December 2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1007%2FBF02983811">"The role of the MLL gene in infant leukemia"</a>. <i>International Journal of Hematology</i>. <b>78</b> (5): <span class="nowrap">390–</span>401. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1007%2FBF02983811">10.1007/BF02983811</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14704031">14704031</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:39901963">39901963</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=International+Journal+of+Hematology&rft.atitle=The+role+of+the+MLL+gene+in+infant+leukemia&rft.volume=78&rft.issue=5&rft.pages=%3Cspan+class%3D%22nowrap%22%3E390-%3C%2Fspan%3E401&rft.date=2003-12&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A39901963%23id-name%3DS2CID&rft_id=info%3Apmid%2F14704031&rft_id=info%3Adoi%2F10.1007%2FBF02983811&rft.aulast=Eguchi&rft.aufirst=M&rft.au=Eguchi-Ishimae%2C+M&rft.au=Greaves%2C+M&rft_id=https%3A%2F%2Fdoi.org%2F10.1007%252FBF02983811&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDaserRabbitts2004" class="citation journal cs1">Daser A, Rabbitts TH (May 2004). <a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgad.1195504">"Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis"</a>. <i>Genes & Development</i>. <b>18</b> (9): <span class="nowrap">965–</span>74. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgad.1195504">10.1101/gad.1195504</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15132992">15132992</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genes+%26+Development&rft.atitle=Extending+the+repertoire+of+the+mixed-lineage+leukemia+gene+MLL+in+leukemogenesis&rft.volume=18&rft.issue=9&rft.pages=%3Cspan+class%3D%22nowrap%22%3E965-%3C%2Fspan%3E74&rft.date=2004-05&rft_id=info%3Adoi%2F10.1101%2Fgad.1195504&rft_id=info%3Apmid%2F15132992&rft.aulast=Daser&rft.aufirst=A&rft.au=Rabbitts%2C+TH&rft_id=https%3A%2F%2Fdoi.org%2F10.1101%252Fgad.1195504&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLiLiuLiang2005" class="citation journal cs1">Li ZY, Liu DP, Liang CC (February 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fsj.leu.2403602">"New insight into the molecular mechanisms of MLL-associated leukemia"</a>. <i>Leukemia</i>. <b>19</b> (2): <span class="nowrap">183–</span>90. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fsj.leu.2403602">10.1038/sj.leu.2403602</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15618964">15618964</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Leukemia&rft.atitle=New+insight+into+the+molecular+mechanisms+of+MLL-associated+leukemia&rft.volume=19&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E183-%3C%2Fspan%3E90&rft.date=2005-02&rft_id=info%3Adoi%2F10.1038%2Fsj.leu.2403602&rft_id=info%3Apmid%2F15618964&rft.aulast=Li&rft.aufirst=ZY&rft.au=Liu%2C+DP&rft.au=Liang%2C+CC&rft_id=https%3A%2F%2Fdoi.org%2F10.1038%252Fsj.leu.2403602&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDouet-GuilbertMorelLe_BrisSassolas2005" class="citation journal cs1">Douet-Guilbert N, Morel F, Le Bris MJ, Sassolas B, Giroux JD, De Braekeleer M (January 2005). "Rearrangement of MLL in a patient with congenital acute monoblastic leukemia and granulocytic sarcoma associated with a t(1;11)(p36;q23) translocation". <i>Leukemia & Lymphoma</i>. <b>46</b> (1): <span class="nowrap">143–</span>6. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1080%2F104281904000010783">10.1080/104281904000010783</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15621793">15621793</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:6686086">6686086</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Leukemia+%26+Lymphoma&rft.atitle=Rearrangement+of+MLL+in+a+patient+with+congenital+acute+monoblastic+leukemia+and+granulocytic+sarcoma+associated+with+a+t%281%3B11%29%28p36%3Bq23%29+translocation&rft.volume=46&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E143-%3C%2Fspan%3E6&rft.date=2005-01&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A6686086%23id-name%3DS2CID&rft_id=info%3Apmid%2F15621793&rft_id=info%3Adoi%2F10.1080%2F104281904000010783&rft.aulast=Douet-Guilbert&rft.aufirst=N&rft.au=Morel%2C+F&rft.au=Le+Bris%2C+MJ&rft.au=Sassolas%2C+B&rft.au=Giroux%2C+JD&rft.au=De+Braekeleer%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3AKMT2A" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=KMT2A&action=edit&section=12" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="http://omim.org/entry/159555">MLL OMIM Entry:</a> MYELOID/LYMPHOID OR MIXED LINEAGE LEUKEMIA GENE; <b>MLL</b></li> <li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=MLL+protein%2C+human">MLL+protein,+human</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li> <li><a rel="nofollow" class="external text" href="https://web.archive.org/web/20111007123411/http://atlasgeneticsoncology.org/Genes/MLL.html">Gene MLL</a> on the <a href="/wiki/Atlas_of_Genetics_and_Cytogenetics_in_Oncology_and_Haematology" title="Atlas of Genetics and Cytogenetics in Oncology and Haematology">Atlas of Genetics and Oncology</a></li></ul> <div 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receptors</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(1)_Basic_domains178" style="font-size:114%;margin:0 4em"><i>(1) Basic domains</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.1) Basic</i> <a href="/wiki/Leucine_zipper" title="Leucine zipper">leucine zipper</a> (<a href="/wiki/BZIP_domain" title="BZIP domain">bZIP</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activating_transcription_factor" title="Activating transcription factor">Activating transcription factor</a> <ul><li><a href="/wiki/Apoptosis-antagonizing_transcription_factor" class="mw-redirect" title="Apoptosis-antagonizing transcription factor">AATF</a></li> <li><a href="/wiki/ATF1" title="ATF1">1</a></li> <li><a href="/wiki/Activating_transcription_factor_2" title="Activating transcription factor 2">2</a></li> <li><a href="/wiki/ATF3" title="ATF3">3</a></li> <li><a href="/wiki/ATF4" title="ATF4">4</a></li> <li><a href="/wiki/ATF5" title="ATF5">5</a></li> <li><a href="/wiki/ATF6" title="ATF6">6</a></li> <li><a href="/wiki/ATF7" title="ATF7">7</a></li></ul></li> <li><a href="/wiki/AP-1_transcription_factor" title="AP-1 transcription factor">AP-1</a> <ul><li><a href="/wiki/C-Fos" class="mw-redirect" title="C-Fos">c-Fos</a></li> <li><a href="/wiki/FOSB" title="FOSB">FOSB</a></li> <li><a href="/wiki/FOSL1" title="FOSL1">FOSL1</a></li> <li><a href="/wiki/FOSL2" title="FOSL2">FOSL2</a></li> <li><a href="/wiki/Jun_dimerization_protein" title="Jun dimerization protein">JDP2</a></li> <li><a href="/wiki/C-jun" class="mw-redirect" title="C-jun">c-Jun</a></li> <li><a href="/wiki/JUNB" title="JUNB">JUNB</a></li> <li><a href="/wiki/JunD" title="JunD">JunD</a></li></ul></li> <li><i>BACH</i> <ul><li><a href="/wiki/BACH1" title="BACH1">1</a></li> <li><a href="/wiki/BACH2" title="BACH2">2</a></li></ul></li> <li><a href="/wiki/BATF_(gene)" title="BATF (gene)">BATF</a></li> <li><a href="/wiki/BLZF1" title="BLZF1">BLZF1</a></li> <li><a href="/wiki/Ccaat-enhancer-binding_proteins" class="mw-redirect" title="Ccaat-enhancer-binding proteins">C/EBP</a> <ul><li><a href="/wiki/CEBPA" title="CEBPA">α</a></li> <li><a href="/wiki/CEBPB" title="CEBPB">β</a></li> <li><a href="/wiki/CEBPG" title="CEBPG">γ</a></li> <li><a href="/wiki/CEBPD" title="CEBPD">δ</a></li> <li><a href="/wiki/CEBPE" title="CEBPE">ε</a></li> <li><a href="/wiki/CCAAT/enhancer_binding_protein_zeta" title="CCAAT/enhancer binding protein zeta">ζ</a></li></ul></li> <li><a href="/wiki/CREB" title="CREB">CREB</a> <ul><li><a href="/wiki/CREB1" title="CREB1">1</a></li> <li><a href="/wiki/CREB3" title="CREB3">3</a></li> <li><a href="/wiki/CREBL1" title="CREBL1">L1</a></li></ul></li> <li><a href="/wiki/CAMP_responsive_element_modulator" title="CAMP responsive element modulator">CREM</a></li> <li><a href="/wiki/DBP_(gene)" title="DBP (gene)">DBP</a></li> <li><a href="/wiki/DNA_damage-inducible_transcript_3" title="DNA damage-inducible transcript 3">DDIT3</a></li> <li><a href="/wiki/GABPA" title="GABPA">GABPA</a></li> <li><a href="/wiki/Gcn4" title="Gcn4">GCN4</a></li> <li><a href="/wiki/HLF_(gene)" title="HLF (gene)">HLF</a></li> <li><a href="/wiki/MAF_(gene)" title="MAF (gene)">MAF</a> <ul><li><a href="/wiki/MAFB_(gene)" title="MAFB (gene)">B</a></li> <li><a href="/wiki/MAFF_(gene)" title="MAFF (gene)">F</a></li> <li><a href="/wiki/MAFG" title="MAFG">G</a></li> <li><a href="/wiki/MAFK" title="MAFK">K</a></li></ul></li> <li><i>NFE</i> <ul><li><a href="/wiki/NFE2" title="NFE2">2</a></li> <li><a href="/wiki/NFE2L1" title="NFE2L1">L1</a></li> <li><a href="/wiki/NFE2L2" title="NFE2L2">L2</a></li> <li><a href="/wiki/NFE2L3" title="NFE2L3">L3</a></li></ul></li> <li><a href="/wiki/NFIL3" title="NFIL3">NFIL3</a></li> <li><a href="/wiki/NRL_(gene)" title="NRL (gene)">NRL</a></li> <li><i>NRF</i> <ul><li><a href="/wiki/NRF1" title="NRF1">1</a></li> <li><a href="/wiki/NFE2L2" title="NFE2L2">2</a></li> <li><a href="/wiki/NFE2L3" title="NFE2L3">3</a></li></ul></li> <li><a href="/wiki/XBP1" title="XBP1">XBP1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.2) Basic helix-loop-helix</i> (<a href="/wiki/Basic_helix-loop-helix" class="mw-redirect" title="Basic helix-loop-helix">bHLH</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group A</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Achaete-scute_complex" title="Achaete-scute complex">AS-C</a> <ul><li><a href="/wiki/ASCL1" title="ASCL1">ASCL1</a></li> <li><a href="/wiki/ASCL2" title="ASCL2">ASCL2</a></li></ul></li> <li><a href="/wiki/ATOH1" title="ATOH1">ATOH1</a></li> <li><i>HAND</i> <ul><li><a href="/wiki/HAND1" title="HAND1">1</a></li> <li><a href="/wiki/HAND2" title="HAND2">2</a></li></ul></li> <li><a href="/wiki/MESP2" title="MESP2">MESP2</a></li> <li><a href="/wiki/Myogenic_regulatory_factors" title="Myogenic regulatory factors">Myogenic regulatory factors</a> <ul><li><a href="/wiki/MyoD" title="MyoD">MyoD</a></li> <li><a href="/wiki/Myogenin" title="Myogenin">Myogenin</a></li> <li><a href="/wiki/MYF5" title="MYF5">MYF5</a></li> <li><a href="/wiki/MYF6" title="MYF6">MYF6</a></li></ul></li> <li><a href="/wiki/NeuroD" title="NeuroD">NeuroD</a> <ul><li><a href="/wiki/NEUROD1" title="NEUROD1">1</a></li> <li><a href="/wiki/NEUROD2" title="NEUROD2">2</a></li></ul></li> <li><a href="/wiki/Neurogenins" title="Neurogenins">Neurogenins</a> <ul><li><a href="/wiki/NEUROG1" class="mw-redirect" title="NEUROG1">1</a></li> <li><a href="/wiki/NEUROG2" class="mw-redirect" title="NEUROG2">2</a></li> <li><a href="/wiki/NEUROG3" class="mw-redirect" title="NEUROG3">3</a></li></ul></li> <li><i>OLIG</i> <ul><li><a href="/wiki/OLIG1" title="OLIG1">1</a></li> <li><a href="/wiki/OLIG2" title="OLIG2">2</a></li></ul></li> <li><i>Paraxis</i> <ul><li><a href="/wiki/TCF15" title="TCF15">TCF15</a></li> <li><a href="/wiki/Scleraxis" title="Scleraxis">Scleraxis</a></li></ul></li> <li><i>SLC</i> <ul><li><a href="/wiki/LYL1" title="LYL1">LYL1</a></li> <li><i>TAL</i> <ul><li><a href="/wiki/TAL1" title="TAL1">1</a></li> <li><a href="/wiki/TAL2" title="TAL2">2</a></li></ul></li></ul></li> <li><a href="/wiki/Twist_transcription_factor" class="mw-redirect" title="Twist transcription factor">Twist</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group B</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/FIGLA" title="FIGLA">FIGLA</a></li> <li><a href="/wiki/Myc" title="Myc">Myc</a> <ul><li><a href="/wiki/MYC" title="MYC">c-Myc</a></li> <li><a href="/wiki/MYCL" title="MYCL">l-Myc</a></li> <li><a href="/wiki/N-Myc" title="N-Myc">n-Myc</a></li></ul></li> <li><a href="/wiki/MXD4" title="MXD4">MXD4</a></li> <li><a href="/wiki/TCF4" title="TCF4">TCF4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group C<br />bHLH-<a href="/wiki/PAS_domain" title="PAS domain">PAS</a></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aryl_hydrocarbon_receptor" title="Aryl hydrocarbon receptor">AhR</a></li> <li><a href="/wiki/Aryl_hydrocarbon_receptor_repressor" title="Aryl hydrocarbon receptor repressor">AHRR</a></li> <li><a href="/wiki/Aryl_hydrocarbon_receptor_nuclear_translocator" title="Aryl hydrocarbon receptor nuclear translocator">ARNT</a> <ul><li><a href="/wiki/ARNTL" class="mw-redirect" title="ARNTL">ARNTL</a></li> <li><a href="/wiki/ARNTL2" title="ARNTL2">ARNTL2</a></li></ul></li> <li><a href="/wiki/CLOCK" title="CLOCK">CLOCK</a></li> <li><a href="/wiki/Hypoxia-inducible_factor" title="Hypoxia-inducible factor">HIF</a> <ul><li><a href="/wiki/HIF1A" title="HIF1A">1A</a></li> <li><a href="/wiki/EPAS1" title="EPAS1">EPAS1</a></li> <li><a href="/wiki/HIF3A" title="HIF3A">3A</a></li></ul></li> <li>NPAS <ul><li><a href="/wiki/NPAS1" title="NPAS1">1</a></li> <li><a href="/wiki/NPAS2" title="NPAS2">2</a></li> <li><a href="/wiki/NPAS3" title="NPAS3">3</a></li></ul></li> <li><i>PER</i> <ul><li><a href="/wiki/PER1" class="mw-redirect" title="PER1">1</a></li> <li><a href="/wiki/PER2" title="PER2">2</a></li> <li><a href="/wiki/PER3" title="PER3">3</a></li> <li><a href="/wiki/Period_(gene)" title="Period (gene)">Period</a></li></ul></li> <li><i>SIM</i> <ul><li><a href="/wiki/SIM1" title="SIM1">1</a></li> <li><a href="/wiki/SIM2" title="SIM2">2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group D</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>BHLH</i> <ul><li><a href="/wiki/BHLHB2" title="BHLHB2">2</a></li> <li><a href="/wiki/BHLHB3" class="mw-redirect" title="BHLHB3">3</a></li> <li><a href="/wiki/BHLHA9" title="BHLHA9">9</a></li></ul></li> <li><a href="/wiki/Pho4" title="Pho4">Pho4</a></li> <li><i>ID</i> <ul><li><a href="/wiki/ID1" title="ID1">1</a></li> <li><a href="/wiki/ID2" title="ID2">2</a></li> <li><a href="/wiki/ID3_(gene)" title="ID3 (gene)">3</a></li> <li><a href="/wiki/ID4" title="ID4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group E</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>HES</i> <ul><li><a href="/wiki/HES1" title="HES1">1</a></li> <li><a href="/wiki/Hes_family_bhlh_transcription_factor_2" title="Hes family bhlh transcription factor 2">2</a></li> <li><a href="/wiki/HES3" title="HES3">3</a></li> <li><a href="/wiki/HES4" title="HES4">4</a></li> <li><a href="/wiki/HES5" title="HES5">5</a></li> <li><a href="/wiki/HES6" title="HES6">6</a></li> <li><a href="/wiki/HES7_gene" title="HES7 gene">7</a></li></ul></li> <li><i>HEY</i> <ul><li><a href="/wiki/HEY1" title="HEY1">1</a></li> <li><a href="/wiki/HEY2" title="HEY2">2</a></li> <li><a href="/wiki/HEYL" title="HEYL">L</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">Group F<br />bHLH-COE</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/EBF1" title="EBF1">EBF1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.3)</i> <a href="/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors" title="Basic helix-loop-helix leucine zipper transcription factors">bHLH-ZIP</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TFAP4" title="TFAP4">AP-4</a></li> <li><a href="/wiki/MAX_(gene)" title="MAX (gene)">MAX</a> <ul><li><a href="/wiki/MXD1" title="MXD1">MXD1</a></li> <li><a href="/wiki/MXD3" title="MXD3">MXD3</a></li></ul></li> <li><a href="/wiki/Microphthalmia-associated_transcription_factor" title="Microphthalmia-associated transcription factor">MITF</a></li> <li><a href="/wiki/MNT_(gene)" title="MNT (gene)">MNT</a></li> <li><a href="/wiki/MLX_(gene)" title="MLX (gene)">MLX</a></li> <li><a href="/wiki/Carbohydrate-responsive_element-binding_protein" title="Carbohydrate-responsive element-binding protein">MLXIPL</a></li> <li><a href="/wiki/MXI1" title="MXI1">MXI1</a></li> <li><a href="/wiki/Myc" title="Myc">Myc</a></li> <li><a href="/wiki/Sterol_regulatory_element-binding_protein" title="Sterol regulatory element-binding protein">SREBP</a> <ul><li><a href="/wiki/SREBF1" class="mw-redirect" title="SREBF1">1</a></li> <li><a href="/wiki/SREBF2" class="mw-redirect" title="SREBF2">2</a></li></ul></li> <li><a href="/wiki/USF1" title="USF1">USF1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.4) NF-1</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nuclear_factor_I" title="Nuclear factor I">NFI</a> <ul><li><a href="/wiki/NFIA" title="NFIA">A</a></li> <li><a href="/wiki/NFIB_(gene)" title="NFIB (gene)">B</a></li> <li><a href="/wiki/NFIC_(gene)" title="NFIC (gene)">C</a></li> <li><a href="/wiki/NFIX" title="NFIX">X</a></li></ul></li> <li><a href="/wiki/SMAD_(protein)" title="SMAD (protein)">SMAD</a> <ul><li><a href="/wiki/R-SMAD" title="R-SMAD">R-SMAD</a> <ul><li><a href="/wiki/Mothers_against_decapentaplegic_homolog_1" title="Mothers against decapentaplegic homolog 1">1</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_2" title="Mothers against decapentaplegic homolog 2">2</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_3" title="Mothers against decapentaplegic homolog 3">3</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_5" title="Mothers against decapentaplegic homolog 5">5</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_9" title="Mothers against decapentaplegic homolog 9">9</a></li></ul></li> <li><a href="/wiki/I-SMAD" title="I-SMAD">I-SMAD</a> <ul><li><a href="/wiki/Mothers_against_decapentaplegic_homolog_6" title="Mothers against decapentaplegic homolog 6">6</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_7" title="Mothers against decapentaplegic homolog 7">7</a></li></ul></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_4" title="Mothers against decapentaplegic homolog 4">4</a>)</li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.5) RF-X</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><i>RFX</i> <ul><li><a href="/wiki/RFX1" title="RFX1">1</a></li> <li><a href="/wiki/RFX2" title="RFX2">2</a></li> <li><a href="/wiki/RFX3" title="RFX3">3</a></li> <li><a href="/wiki/RFX4" title="RFX4">4</a></li> <li><a href="/wiki/RFX5" title="RFX5">5</a></li> <li><a href="/wiki/RFX6" title="RFX6">6</a></li> <li><a href="/wiki/RFXANK" title="RFXANK">ANK</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(1.6) Basic helix-span-helix (bHSH)</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activating_protein_2" title="Activating protein 2">AP-2</a> <ul><li><a href="/wiki/TFAP2A" title="TFAP2A">α</a></li> <li><a href="/wiki/TFAP2B" title="TFAP2B">β</a></li> <li><a href="/wiki/TFAP2C" title="TFAP2C">γ</a></li> <li><a href="/wiki/TFAP2D" title="TFAP2D">δ</a></li> <li><a href="/wiki/TFAP2E" title="TFAP2E">ε</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(2)_Zinc_finger_DNA-binding_domains178" style="font-size:114%;margin:0 4em"><i>(2)</i> <a href="/wiki/Zinc_finger" title="Zinc finger">Zinc finger</a> DNA-binding domains</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.1)</i> <a href="/wiki/Nuclear_receptor" title="Nuclear receptor">Nuclear receptor</a> <i>(Cys<sub>4</sub>)</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 1</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Thyroid_hormone_receptor" title="Thyroid hormone receptor">Thyroid hormone</a> <ul><li><a href="/wiki/Thyroid_hormone_receptor_alpha" title="Thyroid hormone receptor alpha">α</a></li> <li><a href="/wiki/Thyroid_hormone_receptor_beta" title="Thyroid hormone receptor beta">β</a></li></ul></li> <li><a href="/wiki/Constitutive_androstane_receptor" title="Constitutive androstane receptor">CAR</a></li> <li><a href="/wiki/Farnesoid_X_receptor" title="Farnesoid X receptor">FXR</a></li> <li><a href="/wiki/Liver_X_receptor" title="Liver X receptor">LXR</a> <ul><li><a href="/wiki/Liver_X_receptor_alpha" title="Liver X receptor alpha">α</a></li> <li><a href="/wiki/Liver_X_receptor_beta" title="Liver X receptor beta">β</a></li></ul></li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor" title="Peroxisome proliferator-activated receptor">PPAR</a> <ul><li><a href="/wiki/Peroxisome_proliferator-activated_receptor_alpha" title="Peroxisome proliferator-activated receptor alpha">α</a></li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor_delta" title="Peroxisome proliferator-activated receptor delta">β/δ</a></li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor_gamma" title="Peroxisome proliferator-activated receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/Pregnane_X_receptor" title="Pregnane X receptor">PXR</a></li> <li><a href="/wiki/Retinoic_acid_receptor" title="Retinoic acid receptor">RAR</a> <ul><li><a href="/wiki/Retinoic_acid_receptor_alpha" title="Retinoic acid receptor alpha">α</a></li> <li><a href="/wiki/Retinoic_acid_receptor_beta" title="Retinoic acid receptor beta">β</a></li> <li><a href="/wiki/Retinoic_acid_receptor_gamma" title="Retinoic acid receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/RAR-related_orphan_receptor" title="RAR-related orphan receptor">ROR</a> <ul><li><a href="/wiki/RAR-related_orphan_receptor_alpha" title="RAR-related orphan receptor alpha">α</a></li> <li><a href="/wiki/RAR-related_orphan_receptor_beta" title="RAR-related orphan receptor beta">β</a></li> <li><a href="/wiki/RAR-related_orphan_receptor_gamma" title="RAR-related orphan receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/Rev-ErbA" class="mw-redirect" title="Rev-ErbA">Rev-ErbA</a> <ul><li><a href="/wiki/Rev-ErbA_alpha" title="Rev-ErbA alpha">α</a></li> <li><a href="/wiki/Rev-ErbA_beta" title="Rev-ErbA beta">β</a></li></ul></li> <li><a href="/wiki/Calcitriol_receptor" class="mw-redirect" title="Calcitriol receptor">VDR</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 2</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chicken_ovalbumin_upstream_promoter-transcription_factor" title="Chicken ovalbumin upstream promoter-transcription factor">COUP-TF</a> <ul><li>(<a href="/wiki/COUP-TFI" title="COUP-TFI">I</a></li> <li><a href="/wiki/COUP-TFII" title="COUP-TFII">II</a></li></ul></li> <li><a href="/wiki/V-erbA-related_gene" title="V-erbA-related gene">Ear-2</a></li> <li><a href="/wiki/Hepatocyte_nuclear_factor_4" title="Hepatocyte nuclear factor 4">HNF4</a> <ul><li><a href="/wiki/Hepatocyte_nuclear_factor_4_alpha" title="Hepatocyte nuclear factor 4 alpha">α</a></li> <li><a href="/wiki/Hepatocyte_nuclear_factor_4_gamma" title="Hepatocyte nuclear factor 4 gamma">γ</a></li></ul></li> <li><a href="/wiki/Photoreceptor_cell-specific_nuclear_receptor" title="Photoreceptor cell-specific nuclear receptor">PNR</a></li> <li><a href="/wiki/Retinoid_X_receptor" title="Retinoid X receptor">RXR</a> <ul><li><a href="/wiki/Retinoid_X_receptor_alpha" title="Retinoid X receptor alpha">α</a></li> <li><a href="/wiki/Retinoid_X_receptor_beta" title="Retinoid X receptor beta">β</a></li> <li><a href="/wiki/Retinoid_X_receptor_gamma" title="Retinoid X receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/Testicular_receptor" title="Testicular receptor">Testicular receptor</a> <ul><li><a href="/wiki/Testicular_receptor_2" title="Testicular receptor 2">2</a></li> <li><a href="/wiki/Testicular_receptor_4" title="Testicular receptor 4">4</a></li></ul></li> <li><a href="/wiki/TLX" title="TLX">TLX</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 3</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Steroid_hormone_receptor" title="Steroid hormone receptor">Steroid hormone</a> <ul><li><a href="/wiki/Androgen_receptor" title="Androgen receptor">Androgen</a></li> <li><a href="/wiki/Estrogen_receptor" title="Estrogen receptor">Estrogen</a> <ul><li><a href="/wiki/Estrogen_receptor_alpha" title="Estrogen receptor alpha">α</a></li> <li><a href="/wiki/Estrogen_receptor_beta" title="Estrogen receptor beta">β</a></li></ul></li> <li><a href="/wiki/Glucocorticoid_receptor" title="Glucocorticoid receptor">Glucocorticoid</a></li> <li><a href="/wiki/Mineralocorticoid_receptor" title="Mineralocorticoid receptor">Mineralocorticoid</a></li> <li><a href="/wiki/Progesterone_receptor" title="Progesterone receptor">Progesterone</a></li></ul></li> <li><a href="/wiki/Estrogen-related_receptor" title="Estrogen-related receptor">Estrogen related</a> <ul><li><a href="/wiki/Estrogen-related_receptor_alpha" title="Estrogen-related receptor alpha">α</a></li> <li><a href="/wiki/Estrogen-related_receptor_beta" title="Estrogen-related receptor beta">β</a></li> <li><a href="/wiki/Estrogen-related_receptor_gamma" title="Estrogen-related receptor gamma">γ</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 4</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nur_(biology)" class="mw-redirect" title="Nur (biology)">NUR</a> <ul><li><a href="/wiki/Nuclear_receptor_4A1" title="Nuclear receptor 4A1">NGFIB</a></li> <li><a href="/wiki/Nuclear_receptor_4A3" title="Nuclear receptor 4A3">NOR1</a></li> <li><a href="/wiki/Nuclear_receptor_4A2" title="Nuclear receptor 4A2">NURR1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 5</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Liver_receptor_homolog-1" title="Liver receptor homolog-1">LRH-1</a></li> <li><a href="/wiki/Steroidogenic_factor_1" title="Steroidogenic factor 1">SF1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 6</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Germ_cell_nuclear_factor" title="Germ cell nuclear factor">GCNF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>subfamily 0</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/DAX1" title="DAX1">DAX1</a></li> <li><a href="/wiki/Small_heterodimer_partner" title="Small heterodimer partner">SHP</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.2) Other Cys<sub>4</sub></i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/GATA_transcription_factor" title="GATA transcription factor">GATA</a> <ul><li><a href="/wiki/GATA1" title="GATA1">1</a></li> <li><a href="/wiki/GATA2" title="GATA2">2</a></li> <li><a href="/wiki/GATA3" title="GATA3">3</a></li> <li><a href="/wiki/GATA4" title="GATA4">4</a></li> <li><a href="/wiki/GATA5" title="GATA5">5</a></li> <li><a href="/wiki/GATA6" title="GATA6">6</a></li></ul></li> <li><i>MTA</i> <ul><li><a href="/wiki/MTA1" title="MTA1">1</a></li> <li><a href="/wiki/MTA2" title="MTA2">2</a></li> <li><a href="/wiki/MTA3" title="MTA3">3</a></li></ul></li> <li><a href="/wiki/Tricho-rhino-phalangeal_syndrome_Type_1" title="Tricho-rhino-phalangeal syndrome Type 1">TRPS1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.3) Cys<sub>2</sub>His<sub>2</sub></i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/General_transcription_factor" title="General transcription factor">General transcription factors</a> <ul><li><a href="/wiki/Transcription_factor_II_A" title="Transcription factor II A">TFIIA</a></li> <li><a href="/wiki/Transcription_factor_II_B" title="Transcription factor II B">TFIIB</a></li> <li><a href="/wiki/Transcription_factor_II_D" title="Transcription factor II D">TFIID</a></li> <li><a href="/wiki/Transcription_factor_II_E" title="Transcription factor II E">TFIIE</a> <ul><li><a href="/wiki/GTF2E1" title="GTF2E1">1</a></li> <li><a href="/wiki/GTF2E2" title="GTF2E2">2</a></li></ul></li> <li><a href="/wiki/Transcription_factor_II_F" title="Transcription factor II F">TFIIF</a></li> <li><a href="/wiki/GTF2F1" title="GTF2F1">1</a></li> <li><a href="/wiki/GTF2F2" title="GTF2F2">2</a> <ul><li><a href="/wiki/Transcription_factor_II_H" title="Transcription factor II H">TFIIH</a></li> <li><a href="/wiki/GTF2H1" title="GTF2H1">1</a></li> <li><a href="/wiki/GTF2H2" title="GTF2H2">2</a></li> <li><a href="/wiki/GTF2H4" title="GTF2H4">4</a></li> <li><a href="/wiki/GTF2I" title="GTF2I">2I</a></li> <li><a href="/wiki/GTF3A" title="GTF3A">3A</a></li> <li><a href="/wiki/GTF3C1" title="GTF3C1">3C1</a></li> <li><a href="/wiki/GTF3C2" title="GTF3C2">3C2</a></li></ul></li></ul></li></ul> <ul><li><a href="/wiki/ATBF1" title="ATBF1">ATBF1</a></li> <li><i><a href="/wiki/B-cell_CLL/lymphoma" title="B-cell CLL/lymphoma">BCL</a></i> <ul><li><a href="/wiki/BCL6" title="BCL6">6</a></li> <li><a href="/wiki/BCL11A" title="BCL11A">11A</a></li> <li><a href="/wiki/BCL11B" title="BCL11B">11B</a></li></ul></li> <li><a href="/wiki/CTCF" title="CTCF">CTCF</a></li> <li><a href="/wiki/E4F1" title="E4F1">E4F1</a></li> <li><a href="/wiki/Early_growth_response_proteins" title="Early growth response proteins">EGR</a> <ul><li><a href="/wiki/EGR1" title="EGR1">1</a></li> <li><a href="/wiki/EGR2" title="EGR2">2</a></li> <li><a href="/wiki/EGR3" title="EGR3">3</a></li> <li><a href="/wiki/EGR4" title="EGR4">4</a></li></ul></li> <li><a href="/wiki/ERV3" title="ERV3">ERV3</a></li> <li><a href="/wiki/GFI1" title="GFI1">GFI1</a></li> <li><i>GLI family</i> <ul><li><a href="/wiki/GLI1" title="GLI1">1</a></li> <li><a href="/wiki/GLI2" title="GLI2">2</a></li> <li><a href="/wiki/GLI3" title="GLI3">3</a></li> <li><a href="/wiki/RE1-silencing_transcription_factor" title="RE1-silencing transcription factor">REST</a></li> <li><a href="/wiki/GLIS1" title="GLIS1">S1</a></li> <li><a href="/wiki/GLIS2" title="GLIS2">S2</a></li> <li><a href="/wiki/YY1" title="YY1">YY1</a></li></ul></li> <li><i>HIC</i> <ul><li><a href="/wiki/HIC1" title="HIC1">1</a></li> <li><a href="/wiki/HIC2" title="HIC2">2</a></li></ul></li> <li><i>HIVEP</i> <ul><li><a href="/wiki/HIVEP1" title="HIVEP1">1</a></li> <li><a href="/wiki/HIVEP2" title="HIVEP2">2</a></li> <li><a href="/wiki/HIVEP3" title="HIVEP3">3</a></li></ul></li> <li><i>IKZF</i> <ul><li><a href="/wiki/IKZF1" title="IKZF1">1</a></li> <li><a href="/wiki/IKZF2" title="IKZF2">2</a></li> <li><a href="/wiki/IKZF3" title="IKZF3">3</a></li></ul></li> <li><i>ILF</i> <ul><li><a href="/wiki/ILF2" title="ILF2">2</a></li> <li><a href="/wiki/ILF3" title="ILF3">3</a></li></ul></li> <li><a href="/wiki/Kruppel-like_factors" title="Kruppel-like factors">Sp/KLF family</a> <ul><li><i>KLF</i> <ul><li><a href="/wiki/KLF1" title="KLF1">1</a></li> <li><a href="/wiki/KLF2" title="KLF2">2</a></li> <li><a href="/wiki/KLF3" title="KLF3">3</a></li> <li><a href="/wiki/KLF4" title="KLF4">4</a></li> <li><a href="/wiki/KLF5" title="KLF5">5</a></li> <li><a href="/wiki/KLF6" title="KLF6">6</a></li> <li><a href="/wiki/KLF7" title="KLF7">7</a></li> <li><a href="/wiki/KLF8" title="KLF8">8</a></li> <li><a href="/wiki/KLF9" title="KLF9">9</a></li> <li><a href="/wiki/KLF10" title="KLF10">10</a></li> <li><a href="/wiki/KLF11" title="KLF11">11</a></li> <li><a href="/wiki/KLF12" title="KLF12">12</a></li> <li><a href="/wiki/KLF13" title="KLF13">13</a></li> <li><a href="/wiki/KLF14" title="KLF14">14</a></li> <li><a href="/wiki/KLF15" title="KLF15">15</a></li> <li><a href="/wiki/KLF17" title="KLF17">17</a></li></ul></li> <li><i>SP</i> <ul><li><a href="/wiki/Sp1_transcription_factor" class="mw-redirect" title="Sp1 transcription factor">1</a></li> <li><a href="/wiki/SP2_(gene)" class="mw-redirect" title="SP2 (gene)">2</a></li> <li><a href="/wiki/SP4_(gene)" class="mw-redirect" title="SP4 (gene)">4</a></li> <li><a href="/wiki/Sp7_transcription_factor" title="Sp7 transcription factor">7</a></li> <li><a href="/wiki/Sp8_transcription_factor" title="Sp8 transcription factor">8</a></li></ul></li></ul></li> <li><a href="/wiki/MTF1" title="MTF1">MTF1</a></li> <li><a href="/wiki/MYT1" title="MYT1">MYT1</a></li> <li><a href="/wiki/OSR1" title="OSR1">OSR1</a></li> <li><a href="/wiki/PRDM9" title="PRDM9">PRDM9</a></li> <li><i>SALL</i> <ul><li><a href="/wiki/SALL1" title="SALL1">1</a></li> <li><a href="/wiki/SALL2" title="SALL2">2</a></li> <li><a href="/wiki/SALL3" title="SALL3">3</a></li> <li><a href="/wiki/SALL4" title="SALL4">4</a></li></ul></li> <li><a href="/wiki/TSHZ3" title="TSHZ3">TSHZ3</a></li> <li><a href="/wiki/WT1" class="mw-redirect" title="WT1">WT1</a></li> <li><a href="/wiki/Zbtb7" title="Zbtb7">Zbtb7</a> <ul><li><a href="/wiki/ZBTB7A" title="ZBTB7A">7A</a></li> <li><a href="/wiki/ZBTB7B" title="ZBTB7B">7B</a></li></ul></li> <li><i>ZBTB</i> <ul><li><a href="/wiki/ZBTB11" title="ZBTB11">11</a></li> <li><a href="/wiki/Zinc_finger_and_BTB_domain-containing_protein_16" title="Zinc finger and BTB domain-containing protein 16">16</a></li> <li><a href="/wiki/ZBTB17" title="ZBTB17">17</a></li> <li><a href="/wiki/ZBTB20" title="ZBTB20">20</a></li> <li><a href="/wiki/ZBTB21" title="ZBTB21">21</a></li> <li><a href="/wiki/ZBTB32" title="ZBTB32">32</a></li> <li><a href="/wiki/ZBTB33" title="ZBTB33">33</a></li> <li><a href="/wiki/ZBTB40" title="ZBTB40">40</a></li></ul></li> <li><i>zinc finger</i> <ul><li><a href="/wiki/ZNF3" title="ZNF3">3</a></li> <li><a href="/wiki/ZNF7" title="ZNF7">7</a></li> <li><a href="/wiki/CNBP" title="CNBP">9</a></li> <li><a href="/wiki/ZNF10" title="ZNF10">10</a></li> <li><a href="/wiki/ZNF19" title="ZNF19">19</a></li> <li><a href="/wiki/ZNF22" title="ZNF22">22</a></li> <li><a href="/wiki/ZNF24" title="ZNF24">24</a></li> <li><a href="/wiki/ZNF33B" title="ZNF33B">33B</a></li> <li><a href="/wiki/ZNF34" title="ZNF34">34</a></li> <li><a href="/wiki/ZNF35" title="ZNF35">35</a></li> <li><a href="/wiki/ZNF41" title="ZNF41">41</a></li> <li><a href="/wiki/ZNF43" title="ZNF43">43</a></li> <li><a href="/wiki/ZNF44" title="ZNF44">44</a></li> <li><a href="/wiki/BCL6" title="BCL6">51</a></li> <li><a href="/wiki/ZNF74" title="ZNF74">74</a></li> <li><a href="/wiki/ZNF143" title="ZNF143">143</a></li> <li><a href="/wiki/ZNF146" title="ZNF146">146</a></li> <li><a href="/wiki/ZNF148" title="ZNF148">148</a></li> <li><a href="/wiki/Zinc_finger_protein_165" title="Zinc finger protein 165">165</a></li> <li><a href="/wiki/ZNF202" title="ZNF202">202</a></li> <li><a href="/wiki/ZNF217" title="ZNF217">217</a></li> <li><a href="/wiki/ZNF219" title="ZNF219">219</a></li> <li><a href="/wiki/ZNF238" title="ZNF238">238</a></li> <li><a href="/wiki/ZNF239" title="ZNF239">239</a></li> <li><a href="/wiki/ZNF259" title="ZNF259">259</a></li> <li><a href="/wiki/ZNF267" title="ZNF267">267</a></li> <li><a href="/wiki/EGR1" title="EGR1">268</a></li> <li><a href="/wiki/ZNF281" title="ZNF281">281</a></li> <li><a href="/wiki/ZNF300" title="ZNF300">300</a></li> <li><a href="/wiki/ZNF318" title="ZNF318">318</a></li> <li><a href="/wiki/ZNF330" title="ZNF330">330</a></li> <li><a href="/wiki/ZNF346" title="ZNF346">346</a></li> <li><a href="/wiki/ZNF350" title="ZNF350">350</a></li> <li><a href="/wiki/ZNF365" title="ZNF365">365</a></li> <li><a href="/wiki/ZNF366" title="ZNF366">366</a></li> <li><a href="/wiki/ZNF384" title="ZNF384">384</a></li> <li><a href="/wiki/ZNF423" title="ZNF423">423</a></li> <li><a href="/wiki/ZNF451" title="ZNF451">451</a></li> <li><a href="/wiki/ZNF452" title="ZNF452">452</a></li> <li><a href="/wiki/ZNF471" title="ZNF471">471</a></li> <li><a href="/wiki/ZNF593" title="ZNF593">593</a></li> <li><a href="/wiki/ZNF638" title="ZNF638">638</a></li> <li><a href="/wiki/ZNF644" title="ZNF644">644</a></li> <li><a href="/wiki/ZNF649" title="ZNF649">649</a></li> <li><a href="/wiki/ZNF655" title="ZNF655">655</a></li> <li><a href="/wiki/ZNF804A" class="mw-redirect" title="ZNF804A">804A</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.4) Cys<sub>6</sub></i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HIVEP1" title="HIVEP1">HIVEP1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.5) Alternating composition</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Autoimmune_regulator" title="Autoimmune regulator">AIRE</a></li> <li><a href="/wiki/DIDO1" title="DIDO1">DIDO1</a></li> <li><a href="/wiki/GRLF1" title="GRLF1">GRLF1</a></li> <li><i>ING</i> <ul><li><a href="/wiki/ING1" title="ING1">1</a></li> <li><a href="/wiki/ING2" title="ING2">2</a></li> <li><a href="/wiki/ING4" title="ING4">4</a></li></ul></li> <li><i>JARID</i> <ul><li><a href="/wiki/KDM5A" title="KDM5A">1A</a></li> <li><a href="/wiki/KDM5B" class="mw-redirect" title="KDM5B">1B</a></li> <li><a href="/wiki/KDM5C" title="KDM5C">1C</a></li> <li><a href="/wiki/KDM5D" title="KDM5D">1D</a></li> <li><a href="/wiki/JARID2" title="JARID2">2</a></li></ul></li> <li><a href="/wiki/KDM3B" title="KDM3B">JMJD1B</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(2.6) WRKY</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/WRKY_protein_domain" title="WRKY protein domain">WRKY</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(3)_Helix-turn-helix_domains178" style="font-size:114%;margin:0 4em"><i>(3)</i> <a href="/wiki/Helix-turn-helix" title="Helix-turn-helix">Helix-turn-helix</a> <i>domains</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.1)</i> <a href="/wiki/Homeodomain_fold" class="mw-redirect" title="Homeodomain fold">Homeodomain</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i><a href="/wiki/Antennapedia" title="Antennapedia">Antennapedia</a></i></span><br /><span class="nobold"><i>ANTP class</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>protoHOX</i></span><br /><span class="nobold"><i>Hox-like</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ParaHox" title="ParaHox">ParaHox</a> <ul><li><a href="/wiki/Gsx_(gene_family)" title="Gsx (gene family)">Gsx</a> <ul><li><a href="/wiki/GSX1" title="GSX1">1</a></li> <li><a href="/wiki/GSX2" title="GSX2">2</a></li></ul></li> <li><a href="/wiki/Xlox" class="mw-redirect" title="Xlox">Xlox</a> <ul><li><a href="/wiki/PDX1" title="PDX1">PDX1</a></li></ul></li> <li><a href="/wiki/Cdx" title="Cdx">Cdx</a> <ul><li><a href="/wiki/CDX1" class="mw-redirect" title="CDX1">1</a></li> <li><a href="/wiki/CDX2" class="mw-redirect" title="CDX2">2</a></li> <li><a href="/wiki/CDX4_(gene)" class="mw-redirect" title="CDX4 (gene)">4</a></li></ul></li></ul></li> <li>extended Hox: <a href="/wiki/Evx1" title="Evx1">Evx1</a></li> <li><a href="/w/index.php?title=Evx2&action=edit&redlink=1" class="new" title="Evx2 (page does not exist)">Evx2</a></li> <li><a href="/wiki/MEOX1" title="MEOX1">MEOX1</a></li> <li><a href="/wiki/MEOX2" title="MEOX2">MEOX2</a></li> <li><a href="/wiki/Homeobox" title="Homeobox">Homeobox</a> <ul><li><a href="/wiki/Homeobox_A1" title="Homeobox A1">A1</a></li> <li><a href="/wiki/HOXA2" title="HOXA2">A2</a></li> <li><a href="/wiki/HOXA3" title="HOXA3">A3</a></li> <li><a href="/wiki/HOXA4" title="HOXA4">A4</a></li> <li><a href="/wiki/HOXA5" title="HOXA5">A5</a></li> <li><a href="/wiki/HOXA7" title="HOXA7">A7</a></li> <li><a href="/wiki/HOXA9" title="HOXA9">A9</a></li> <li><a href="/wiki/Homeobox_A10" title="Homeobox A10">A10</a></li> <li><a href="/wiki/HOXA11" title="HOXA11">A11</a></li> <li><a href="/wiki/HOXA13" title="HOXA13">A13</a></li> <li><a href="/wiki/HOXB1" title="HOXB1">B1</a></li> <li><a href="/wiki/HOXB2" title="HOXB2">B2</a></li> <li><a href="/wiki/HOXB3" title="HOXB3">B3</a></li> <li><a href="/wiki/HOXB4" title="HOXB4">B4</a></li> <li><a href="/wiki/HOXB5" title="HOXB5">B5</a></li> <li><a href="/wiki/HOXB6" title="HOXB6">B6</a></li> <li><a href="/wiki/HOXB7" title="HOXB7">B7</a></li> <li><a href="/wiki/HOXB8" title="HOXB8">B8</a></li> <li><a href="/wiki/HOXB9" title="HOXB9">B9</a></li> <li><a href="/wiki/HOXB13" title="HOXB13">B13</a></li> <li><a href="/wiki/HOXC4" title="HOXC4">C4</a></li> <li><a href="/wiki/HOXC5" title="HOXC5">C5</a></li> <li><a href="/wiki/HOXC6" title="HOXC6">C6</a></li> <li><a href="/wiki/HOXC8" title="HOXC8">C8</a></li> <li><a href="/wiki/HOXC9" title="HOXC9">C9</a></li> <li><a href="/wiki/HOXC10" title="HOXC10">C10</a></li> <li><a href="/wiki/HOXC11" title="HOXC11">C11</a></li> <li><a href="/wiki/HOXC12" title="HOXC12">C12</a></li> <li><a href="/wiki/HOXC13" title="HOXC13">C13</a></li> <li><a href="/wiki/HOXD1" title="HOXD1">D1</a></li> <li><a href="/wiki/HOXD3" title="HOXD3">D3</a></li> <li><a href="/wiki/HOXD4" title="HOXD4">D4</a></li> <li><a href="/wiki/HOXD8" title="HOXD8">D8</a></li> <li><a href="/wiki/HOXD9" title="HOXD9">D9</a></li> <li><a href="/wiki/HOXD10" title="HOXD10">D10</a></li> <li><a href="/wiki/HOXD11" title="HOXD11">D11</a></li> <li><a href="/wiki/HOXD12" title="HOXD12">D12</a></li> <li><a href="/wiki/HOXD13" title="HOXD13">D13</a></li></ul></li> <li><a href="/w/index.php?title=GBX1&action=edit&redlink=1" class="new" title="GBX1 (page does not exist)">GBX1</a></li> <li><a href="/wiki/GBX2" title="GBX2">GBX2</a></li> <li><a href="/wiki/MNX1" title="MNX1">MNX1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>metaHOX</i></span><br /><span class="nobold"><i>NK-like</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=BARHL1&action=edit&redlink=1" class="new" title="BARHL1 (page does not exist)">BARHL1</a></li> <li><a href="/wiki/BARHL2" title="BARHL2">BARHL2</a></li> <li><a href="/w/index.php?title=BARX1&action=edit&redlink=1" class="new" title="BARX1 (page does not exist)">BARX1</a></li> <li><a href="/w/index.php?title=BARX2&action=edit&redlink=1" class="new" title="BARX2 (page does not exist)">BARX2</a></li> <li><a href="/wiki/Brain-specific_homeobox" title="Brain-specific homeobox">BSX</a></li> <li><i>DBX</i> <ul><li><a href="/wiki/DBX1" title="DBX1">1</a></li> <li><a href="/wiki/DBX2" title="DBX2">2</a></li></ul></li> <li><a href="/wiki/DLX_gene_family" title="DLX gene family">DLX</a> <ul><li><a href="/wiki/DLX1" title="DLX1">1</a></li> <li><a href="/wiki/DLX2" title="DLX2">2</a></li> <li><a href="/wiki/DLX3_(gene)" class="mw-redirect" title="DLX3 (gene)">3</a></li> <li><a href="/wiki/DLX4" title="DLX4">4</a></li> <li><a href="/wiki/DLX5" title="DLX5">5</a></li> <li><a href="/wiki/DLX6" title="DLX6">6</a></li></ul></li> <li><i><a href="/wiki/EMX_homeogene" title="EMX homeogene">EMX</a></i> <ul><li><a href="/wiki/EMX1" title="EMX1">1</a></li> <li><a href="/wiki/EMX2" title="EMX2">2</a></li></ul></li> <li><i>EN</i> <ul><li><a href="/wiki/EN1_(gene)" title="EN1 (gene)">1</a></li> <li><a href="/wiki/EN2_(gene)" title="EN2 (gene)">2</a></li></ul></li> <li><a href="/wiki/HHEX" title="HHEX">HHEX</a></li> <li><a href="/wiki/HLX_(gene)" title="HLX (gene)">HLX</a></li> <li><a href="/wiki/LBX1" title="LBX1">LBX1</a></li> <li><a href="/wiki/LBX2" title="LBX2">LBX2</a></li> <li><i>MSX</i> <ul><li><a href="/wiki/MSX1" class="mw-redirect" title="MSX1">1</a></li> <li><a href="/wiki/Msh_homeobox_2" title="Msh homeobox 2">2</a></li></ul></li> <li><a href="/wiki/Homeobox_protein_NANOG" title="Homeobox protein NANOG">NANOG</a></li> <li><a href="/wiki/NKX-homeodomain_factor" title="NKX-homeodomain factor">NKX</a> <ul><li><a href="/wiki/NK2_homeobox_1" title="NK2 homeobox 1">2-1</a></li> <li><a href="/wiki/NKX2-2" title="NKX2-2">2-2</a></li> <li><a href="/wiki/NKX2-3" title="NKX2-3">2-3</a></li> <li><a href="/wiki/Homeobox_protein_Nkx-2.5" title="Homeobox protein Nkx-2.5">2-5</a></li> <li><a href="/wiki/NKX3-1" title="NKX3-1">3-1</a></li> <li><a href="/wiki/NKX3-2" title="NKX3-2">3-2</a></li> <li><a href="/w/index.php?title=HMX1&action=edit&redlink=1" class="new" title="HMX1 (page does not exist)">HMX1</a></li> <li><a href="/w/index.php?title=HMX2&action=edit&redlink=1" class="new" title="HMX2 (page does not exist)">HMX2</a></li> <li><a href="/w/index.php?title=HMX3&action=edit&redlink=1" class="new" title="HMX3 (page does not exist)">HMX3</a></li> <li><a href="/wiki/NKX6-1" title="NKX6-1">6-1</a></li> <li><a href="/wiki/NKX6-2" title="NKX6-2">6-2</a></li></ul></li> <li><a href="/wiki/Notochord_homeobox_(NOTO)_gene" title="Notochord homeobox (NOTO) gene">NOTO</a></li> <li><a href="/wiki/TLX1" title="TLX1">TLX1</a></li> <li><a href="/wiki/TLX2" title="TLX2">TLX2</a></li> <li><a href="/wiki/TLX3" title="TLX3">TLX3</a></li> <li><a href="/wiki/VAX1" title="VAX1">VAX1</a></li> <li><a href="/w/index.php?title=VAX2&action=edit&redlink=1" class="new" title="VAX2 (page does not exist)">VAX2</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">other</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aristaless_related_homeobox" title="Aristaless related homeobox">ARX</a></li> <li><a href="/wiki/CRX_(gene)" title="CRX (gene)">CRX</a></li> <li><a href="/wiki/CUTL1" title="CUTL1">CUTL1</a></li> <li><i>FHL</i> <ul><li><a href="/wiki/FHL1" title="FHL1">1</a></li> <li><a href="/wiki/FHL2" title="FHL2">2</a></li> <li><a href="/wiki/FHL3" title="FHL3">3</a></li></ul></li> <li><a href="/wiki/HESX1" title="HESX1">HESX1</a></li> <li><a href="/wiki/HOPX" title="HOPX">HOPX</a></li> <li><i>LMX</i> <ul><li><a href="/wiki/LMX1A" title="LMX1A">1A</a></li> <li><a href="/wiki/LMX1B" title="LMX1B">1B</a></li></ul></li> <li><a href="/wiki/NOBOX" title="NOBOX">NOBOX</a></li> <li>TALE <ul><li><a href="/wiki/Iroquois_homeobox_factor" title="Iroquois homeobox factor">IRX</a> <ul><li><a href="/wiki/IRX1" title="IRX1">1</a></li> <li><a href="/wiki/IRX2" title="IRX2">2</a></li> <li><a href="/wiki/IRX3" title="IRX3">3</a></li> <li><a href="/wiki/IRX4" title="IRX4">4</a></li> <li><a href="/wiki/IRX5" title="IRX5">5</a></li> <li><a href="/wiki/IRX6" title="IRX6">6</a></li> <li><a href="/wiki/MKX" title="MKX">MKX</a></li></ul></li> <li><i>MEIS</i> <ul><li><a href="/wiki/MEIS1" title="MEIS1">1</a></li> <li><a href="/wiki/MEIS2" title="MEIS2">2</a></li></ul></li> <li><i>PBX</i> <ul><li><a href="/wiki/PBX1" title="PBX1">1</a></li> <li><a href="/wiki/PBX2" title="PBX2">2</a></li> <li><a href="/wiki/PBX3" title="PBX3">3</a></li></ul></li> <li><i>PKNOX</i> <ul><li><a href="/wiki/PKNOX1" title="PKNOX1">1</a></li> <li><a href="/wiki/PKNOX2" title="PKNOX2">2</a></li></ul></li> <li><i>SIX</i> <ul><li><a href="/wiki/SIX1" class="mw-redirect" title="SIX1">1</a></li> <li><a href="/wiki/SIX2" title="SIX2">2</a></li> <li><a href="/wiki/SIX3" title="SIX3">3</a></li> <li><a href="/wiki/SIX4" title="SIX4">4</a></li> <li><a href="/wiki/SIX5" title="SIX5">5</a></li></ul></li></ul></li> <li><i>PHF</i> <ul><li><a href="/wiki/PHF1" title="PHF1">1</a></li> <li><a href="/wiki/PHF3" title="PHF3">3</a></li> <li><a href="/wiki/PHF6" title="PHF6">6</a></li> <li><a href="/wiki/PHF8" title="PHF8">8</a></li> <li><a href="/wiki/PHF10" title="PHF10">10</a></li> <li><a href="/wiki/PHF16" title="PHF16">16</a></li> <li><a href="/wiki/PHF17" class="mw-redirect" title="PHF17">17</a></li> <li><a href="/wiki/PHF20" title="PHF20">20</a></li> <li><a href="/wiki/PHF21A" title="PHF21A">21A</a></li></ul></li> <li><a href="/wiki/POU_domain" title="POU domain">POU domain</a> <ul><li><a href="/wiki/Pituitary-specific_positive_transcription_factor_1" title="Pituitary-specific positive transcription factor 1">PIT-1</a></li> <li><a href="/wiki/BRN-3" title="BRN-3">BRN-3</a>: <a href="/wiki/POU4F1" title="POU4F1">A</a></li> <li><a href="/wiki/POU4F2" title="POU4F2">B</a></li> <li><a href="/wiki/POU4F3" title="POU4F3">C</a></li> <li><a href="/wiki/Octamer_transcription_factor" title="Octamer transcription factor">Octamer transcription factor</a>: <a href="/wiki/POU2F1" title="POU2F1">1</a></li> <li><a href="/wiki/Oct-2" title="Oct-2">2</a></li> <li><a href="/wiki/Oct-4" title="Oct-4">3/4</a></li> <li><a href="/wiki/POU3F1" title="POU3F1">6</a></li> <li><a href="/wiki/POU3F2" title="POU3F2">7</a></li> <li><a href="/wiki/POU3F4" title="POU3F4">11</a></li></ul></li> <li><a href="/wiki/SATB2" title="SATB2">SATB2</a></li> <li><i>ZEB</i> <ul><li><a href="/wiki/ZEB1" title="ZEB1">1</a></li> <li><a href="/wiki/ZEB2" title="ZEB2">2</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.2) Paired box</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pax_genes" title="Pax genes">PAX</a> <ul><li><a href="/wiki/PAX1" title="PAX1">1</a></li> <li><a href="/wiki/PAX2" title="PAX2">2</a></li> <li><a href="/wiki/PAX3" title="PAX3">3</a></li> <li><a href="/wiki/PAX4" title="PAX4">4</a></li> <li><a href="/wiki/PAX5" title="PAX5">5</a></li> <li><a href="/wiki/PAX6" title="PAX6">6</a></li> <li><a href="/wiki/PAX7" title="PAX7">7</a></li> <li><a href="/wiki/PAX8" title="PAX8">8</a></li> <li><a href="/wiki/PAX9" title="PAX9">9</a></li></ul></li> <li>PRRX <ul><li><a href="/wiki/PRRX1" title="PRRX1">1</a></li> <li><a href="/wiki/PRRX2" title="PRRX2">2</a></li></ul></li> <li><a href="/wiki/PROP1" title="PROP1">PROP1</a></li> <li><i>PHOX</i> <ul><li><a href="/wiki/PHOX2A" title="PHOX2A">2A</a></li> <li><a href="/wiki/PHOX2B" title="PHOX2B">2B</a></li></ul></li> <li><a href="/wiki/Retinal_homeobox_protein_Rx" title="Retinal homeobox protein Rx">RAX</a></li> <li><a href="/wiki/Short-stature_homeobox_gene" title="Short-stature homeobox gene">SHOX</a></li> <li><a href="/wiki/SHOX2" title="SHOX2">SHOX2</a></li> <li><a href="/wiki/VSX1" title="VSX1">VSX1</a></li> <li><a href="/wiki/VSX2" title="VSX2">VSX2</a></li> <li><a href="/wiki/Bicoid_(gene)" class="mw-redirect" title="Bicoid (gene)">Bicoid</a> <ul><li><a href="/wiki/Goosecoid_protein" class="mw-redirect" title="Goosecoid protein">GSC</a></li> <li><a href="/wiki/BICD2" title="BICD2">BICD2</a></li> <li><i>OTX</i> <ul><li><a href="/wiki/OTX1" title="OTX1">1</a></li> <li><a href="/wiki/Orthodenticle_homeobox_2" title="Orthodenticle homeobox 2">2</a></li></ul></li> <li><i>PITX</i> <ul><li><a href="/wiki/PITX1" title="PITX1">1</a></li> <li><a href="/wiki/PITX2" title="PITX2">2</a></li> <li><a href="/wiki/PITX3" title="PITX3">3</a></li></ul></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.3)</i> <a href="/wiki/FOX_proteins" title="FOX proteins">Fork head</a> / <a href="/wiki/Winged-helix_transcription_factors" title="Winged-helix transcription factors">winged helix</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/E2F" title="E2F">E2F</a> <ul><li><a href="/wiki/E2F1" title="E2F1">1</a></li> <li><a href="/wiki/E2F2" title="E2F2">2</a></li> <li><a href="/wiki/E2F3" title="E2F3">3</a></li> <li><a href="/wiki/E2F4" title="E2F4">4</a></li> <li><a href="/wiki/E2F5" title="E2F5">5</a></li></ul></li> <li><a href="/wiki/FOX_proteins" title="FOX proteins">FOX proteins</a> <ul><li><a href="/wiki/FOXA1" title="FOXA1">A1</a></li> <li><a href="/wiki/FOXA2" title="FOXA2">A2</a></li> <li><a href="/wiki/FOXA3" title="FOXA3">A3</a></li> <li><a href="/wiki/FOXB1" class="mw-redirect" title="FOXB1">B1</a></li> <li><a href="/w/index.php?title=FOXB2&action=edit&redlink=1" class="new" title="FOXB2 (page does not exist)">B2</a></li> <li><a href="/wiki/Forkhead_box_C1" title="Forkhead box C1">C1</a></li> <li><a href="/wiki/FOXC2" title="FOXC2">C2</a></li> <li><a href="/wiki/FOXD1" class="mw-redirect" title="FOXD1">D1</a></li> <li><a href="/w/index.php?title=FOXD2&action=edit&redlink=1" class="new" title="FOXD2 (page does not exist)">D2</a></li> <li><a href="/wiki/FOXD3" title="FOXD3">D3</a></li> <li><a href="/wiki/FOXD4" title="FOXD4">D4</a></li> <li><a href="/w/index.php?title=FOXD4L1&action=edit&redlink=1" class="new" title="FOXD4L1 (page does not exist)">D4L1</a></li> <li><a href="/w/index.php?title=FOXD4L3&action=edit&redlink=1" class="new" title="FOXD4L3 (page does not exist)">D4L3</a></li> <li><a href="/w/index.php?title=FOXD4L4&action=edit&redlink=1" class="new" title="FOXD4L4 (page does not exist)">D4L4</a></li> <li><a href="/w/index.php?title=FOXD4L5&action=edit&redlink=1" class="new" title="FOXD4L5 (page does not exist)">D4L5</a></li> <li><a href="/w/index.php?title=FOXD4L6&action=edit&redlink=1" class="new" title="FOXD4L6 (page does not exist)">D4L6</a></li> <li><a href="/wiki/FOXE1" title="FOXE1">E1</a></li> <li><a href="/wiki/FOXE3" title="FOXE3">E3</a></li> <li><a href="/wiki/FOXF1" title="FOXF1">F1</a></li> <li><a href="/wiki/FOXF2" title="FOXF2">F2</a></li> <li><a href="/wiki/FOXG1" title="FOXG1">G1</a></li> <li><a href="/wiki/FOXH1" title="FOXH1">H1</a></li> <li><a href="/wiki/FOXI1" title="FOXI1">I1</a></li> <li><a href="/w/index.php?title=FOXI2&action=edit&redlink=1" class="new" title="FOXI2 (page does not exist)">I2</a></li> <li><a href="/wiki/FOXI3" title="FOXI3">I3</a></li> <li><a href="/wiki/FOXJ1" title="FOXJ1">J1</a></li> <li><a href="/wiki/FOXJ2" title="FOXJ2">J2</a></li> <li><a href="/w/index.php?title=FOXJ3&action=edit&redlink=1" class="new" title="FOXJ3 (page does not exist)">J3</a></li> <li><a href="/wiki/FOXK1" title="FOXK1">K1</a></li> <li><a href="/wiki/FOXK2" title="FOXK2">K2</a></li> <li><a href="/w/index.php?title=FOXL1&action=edit&redlink=1" class="new" title="FOXL1 (page does not exist)">L1</a></li> <li><a href="/wiki/Forkhead_box_L2" class="mw-redirect" title="Forkhead box L2">L2</a></li> <li><a href="/wiki/FOXM1" title="FOXM1">M1</a></li> <li><a href="/wiki/FOXN1" title="FOXN1">N1</a></li> <li><a href="/w/index.php?title=FOXN2&action=edit&redlink=1" class="new" title="FOXN2 (page does not exist)">N2</a></li> <li><a href="/wiki/FOXN3" title="FOXN3">N3</a></li> <li><a href="/w/index.php?title=FOXN4&action=edit&redlink=1" class="new" title="FOXN4 (page does not exist)">N4</a></li> <li><a href="/wiki/FOXO1" class="mw-redirect" title="FOXO1">O1</a></li> <li><a href="/wiki/FOXO3" title="FOXO3">O3</a></li> <li><a href="/wiki/FOXO4" title="FOXO4">O4</a></li> <li><a href="/wiki/FOXO6" title="FOXO6">O6</a></li> <li><a href="/wiki/FOXP1" title="FOXP1">P1</a></li> <li><a href="/wiki/FOXP2" title="FOXP2">P2</a></li> <li><a href="/wiki/FOXP3" title="FOXP3">P3</a></li> <li><a href="/wiki/FOXP4" title="FOXP4">P4</a></li> <li><a href="/wiki/FOXQ1" title="FOXQ1">Q1</a></li> <li><a href="/w/index.php?title=FOXR1&action=edit&redlink=1" class="new" title="FOXR1 (page does not exist)">R1</a></li> <li><a href="/w/index.php?title=FOXR2&action=edit&redlink=1" class="new" title="FOXR2 (page does not exist)">R2</a></li> <li><a href="/wiki/FOXS1" title="FOXS1">S1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.4)</i> <a href="/wiki/Heat_shock_factor" title="Heat shock factor">Heat shock factors</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Heat_shock_factor" title="Heat shock factor">HSF</a></i> <ul><li><a href="/wiki/HSF1" class="mw-redirect" title="HSF1">1</a></li> <li><a href="/wiki/HSF2" title="HSF2">2</a></li> <li><a href="/wiki/HSF4" title="HSF4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.5) Tryptophan clusters</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><i>ELF</i> <ul><li><a href="/wiki/ELF2" title="ELF2">2</a></li> <li><a href="/wiki/ELF4" title="ELF4">4</a></li> <li><a href="/wiki/ELF5" title="ELF5">5</a></li></ul></li> <li><a href="/wiki/EHF_(gene)" title="EHF (gene)">EHF</a></li> <li><i>ELK</i> <ul><li><a href="/wiki/ELK1" title="ELK1">1</a></li> <li><a href="/wiki/ELK3" title="ELK3">3</a></li> <li><a href="/wiki/ELK4" title="ELK4">4</a></li></ul></li> <li><a href="/wiki/ERF_(gene)" title="ERF (gene)">ERF</a></li> <li><a href="/wiki/ETS_transcription_factor_family" title="ETS transcription factor family">ETS</a> <ul><li><a href="/wiki/ETS1" title="ETS1">1</a></li> <li><a href="/wiki/ETS2" title="ETS2">2</a></li> <li><a href="/wiki/ERG_(gene)" title="ERG (gene)">ERG</a></li> <li><a href="/wiki/SPIB" title="SPIB">SPIB</a></li></ul></li> <li><i>ETV</i> <ul><li><a href="/wiki/ETV1" title="ETV1">1</a></li> <li><a href="/wiki/ETV4" title="ETV4">4</a></li> <li><a href="/wiki/ERM_transcription_factor" class="mw-redirect" title="ERM transcription factor">5</a></li> <li><a href="/wiki/ETV6" title="ETV6">6</a></li></ul></li> <li><a href="/wiki/FLI1" title="FLI1">FLI1</a></li> <li><a href="/wiki/Interferon_regulatory_factors" title="Interferon regulatory factors">Interferon regulatory factors</a> <ul><li><a href="/wiki/IRF1" title="IRF1">1</a></li> <li><a href="/wiki/IRF2" title="IRF2">2</a></li> <li><a href="/wiki/IRF3" title="IRF3">3</a></li> <li><a href="/wiki/IRF4" title="IRF4">4</a></li> <li><a href="/wiki/IRF5" title="IRF5">5</a></li> <li><a href="/wiki/IRF6" title="IRF6">6</a></li> <li><a href="/wiki/IRF7" title="IRF7">7</a></li> <li><a href="/wiki/IRF8" title="IRF8">8</a></li></ul></li> <li><a href="/wiki/MYB_(gene)" title="MYB (gene)">MYB</a></li> <li><a href="/wiki/MYBL2" title="MYBL2">MYBL2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(3.6) TEA domain</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>transcriptional enhancer factor</i> <ul><li><a href="/wiki/TEAD1" title="TEAD1">1</a></li> <li><a href="/wiki/TEAD2" title="TEAD2">2</a></li> <li><a href="/wiki/TEAD3" title="TEAD3">3</a></li> <li><a href="/wiki/TEAD4" title="TEAD4">4</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(4)_β-Scaffold_factors_with_minor_groove_contacts178" style="font-size:114%;margin:0 4em">(4) <i>β-Scaffold factors with minor groove contacts</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.1)</i> <a href="/wiki/Rel_homology_domain" title="Rel homology domain">Rel homology region</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/NF-%CE%BAB" title="NF-κB">NF-κB</a> <ul><li><a href="/wiki/NFKB1" title="NFKB1">NFKB1</a></li> <li><a href="/wiki/NFKB2" title="NFKB2">NFKB2</a></li> <li><a href="/wiki/REL" title="REL">REL</a></li> <li><a href="/wiki/RELA" title="RELA">RELA</a></li> <li><a href="/wiki/RELB" title="RELB">RELB</a></li></ul></li> <li><a href="/wiki/NFAT" title="NFAT">NFAT</a> <ul><li><a href="/wiki/NFATC1" title="NFATC1">C1</a></li> <li><a href="/wiki/NFATC2" title="NFATC2">C2</a></li> <li><a href="/wiki/NFATC3" title="NFATC3">C3</a></li> <li><a href="/wiki/NFATC4" title="NFATC4">C4</a></li> <li><a href="/wiki/NFAT5" title="NFAT5">5</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.2)</i> <a href="/wiki/STAT_protein" title="STAT protein">STAT</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/STAT_protein" title="STAT protein">STAT</a> <ul><li><a href="/wiki/STAT1" title="STAT1">1</a></li> <li><a href="/wiki/STAT2" title="STAT2">2</a></li> <li><a href="/wiki/STAT3" title="STAT3">3</a></li> <li><a href="/wiki/STAT4" title="STAT4">4</a></li> <li><a href="/wiki/STAT5" title="STAT5">5</a></li> <li><a href="/wiki/STAT6" title="STAT6">6</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.3) p53-like</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/P53_p63_p73_family" title="P53 p63 p73 family">p53 p63 p73 family</a> <ul><li><a href="/wiki/P53" title="P53">p53</a></li> <li><a href="/wiki/TP63" title="TP63">TP63</a></li> <li><a href="/wiki/P73" title="P73">p73</a></li></ul></li> <li><a href="/wiki/T-box" title="T-box">TBX</a> <ul><li><a href="/wiki/TBX1" title="TBX1">1</a></li> <li><a href="/wiki/TBX2" title="TBX2">2</a></li> <li><a href="/wiki/TBX3" title="TBX3">3</a></li> <li><a href="/wiki/TBX5_(gene)" title="TBX5 (gene)">5</a></li> <li><a href="/wiki/TBX19" title="TBX19">19</a></li> <li><a href="/wiki/TBX21" title="TBX21">21</a></li> <li><a href="/wiki/TBX22" title="TBX22">22</a></li> <li><a href="/wiki/TBR1" title="TBR1">TBR1</a></li> <li><a href="/wiki/Eomesodermin" title="Eomesodermin">TBR2</a></li> <li><a href="/wiki/Brachyury" class="mw-redirect" title="Brachyury">TFT</a></li></ul></li> <li><a href="/wiki/Myelin_regulatory_factor" title="Myelin regulatory factor">MYRF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.4)</i> <a href="/wiki/MADS-box" title="MADS-box">MADS box</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mef2" title="Mef2">Mef2</a> <ul><li><a href="/wiki/Myocyte-specific_enhancer_factor_2A" title="Myocyte-specific enhancer factor 2A">A</a></li> <li><a href="/wiki/MEF2B" title="MEF2B">B</a></li> <li><a href="/wiki/MEF2C" title="MEF2C">C</a></li> <li><a href="/wiki/MEF2D" title="MEF2D">D</a></li></ul></li> <li><a href="/wiki/Serum_response_factor" title="Serum response factor">SRF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.6)</i> <a href="/wiki/TATA-binding_protein" title="TATA-binding protein">TATA-binding proteins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TATA-binding_protein" title="TATA-binding protein">TBP</a></li> <li><a href="/wiki/TBPL1" title="TBPL1">TBPL1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.7)</i> <a href="/wiki/High-mobility_group" title="High-mobility group">High-mobility group</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/BBX_(gene)" title="BBX (gene)">BBX</a></li> <li><a href="/wiki/HMG-box" title="HMG-box">HMGB</a> <ul><li><a href="/wiki/HMGB1" title="HMGB1">1</a></li> <li><a href="/wiki/HMGB2" title="HMGB2">2</a></li> <li><a href="/wiki/HMGB3" title="HMGB3">3</a></li> <li><a href="/wiki/HMGB4" title="HMGB4">4</a></li></ul></li> <li><a href="/wiki/HMGN" title="HMGN">HMGN</a> <ul><li><a href="/wiki/HMGN1" title="HMGN1">1</a></li> <li><a href="/wiki/HMGN2" title="HMGN2">2</a></li> <li><a href="/wiki/HMGN3" title="HMGN3">3</a></li> <li><a href="/wiki/HMGN4" title="HMGN4">4</a></li></ul></li> <li><i>HNF</i> <ul><li><a href="/wiki/HNF1A" title="HNF1A">1A</a></li> <li><a href="/wiki/HNF1B" title="HNF1B">1B</a></li></ul></li> <li><a href="/wiki/SOX_gene_family" title="SOX gene family">SOX</a> <ul><li><a href="/wiki/SOX1" title="SOX1">1</a></li> <li><a href="/wiki/SOX2" title="SOX2">2</a></li> <li><a href="/wiki/SOX3" title="SOX3">3</a></li> <li><a href="/wiki/SOX4" title="SOX4">4</a></li> <li><a href="/wiki/SOX5" title="SOX5">5</a></li> <li><a href="/wiki/SOX6" title="SOX6">6</a></li> <li><a href="/wiki/SOX8" title="SOX8">8</a></li> <li><a href="/wiki/SOX9" title="SOX9">9</a></li> <li><a href="/wiki/SOX10" title="SOX10">10</a></li> <li><a href="/wiki/SOX11" title="SOX11">11</a></li> <li><a href="/wiki/SOX12" title="SOX12">12</a></li> <li><a href="/wiki/SOX13" title="SOX13">13</a></li> <li><a href="/wiki/SOX14" title="SOX14">14</a></li> <li><a href="/wiki/SOX15" title="SOX15">15</a></li> <li><a href="/wiki/SOX17" title="SOX17">17</a></li> <li><a href="/wiki/SOX18" title="SOX18">18</a></li> <li><a href="/wiki/SOX21" title="SOX21">21</a></li></ul></li> <li><a href="/wiki/Testis_determining_factor" class="mw-redirect" title="Testis determining factor">SRY</a></li> <li><a href="/wiki/Structure_specific_recognition_protein_1" title="Structure specific recognition protein 1">SSRP1</a></li> <li><a href="/wiki/TCF/LEF_family" title="TCF/LEF family">TCF/LEF</a> <ul><li><i>TCF</i> <ul><li><a href="/wiki/TCF7" title="TCF7">1</a></li> <li><a href="/wiki/TCF3" title="TCF3">3</a></li> <li><a href="/wiki/TCF7L2" title="TCF7L2">4</a></li></ul></li> <li><a href="/wiki/Lymphoid_enhancer-binding_factor_1" title="Lymphoid enhancer-binding factor 1">LEF1</a></li></ul></li> <li><i>TOX</i> <ul><li><a href="/wiki/TOX" title="TOX">1</a></li> <li><a href="/wiki/TOX2" title="TOX2">2</a></li> <li><a href="/wiki/TOX3" title="TOX3">3</a></li> <li><a href="/wiki/TOX4" title="TOX4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.9) Grainyhead</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TFCP2" title="TFCP2">TFCP2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.10) Cold-shock domain</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CSDA_(gene)" title="CSDA (gene)">CSDA</a></li> <li><a href="/wiki/Y_box_binding_protein_1" title="Y box binding protein 1">YBX1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(4.11) Runt</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Core_binding_factor" title="Core binding factor">CBF</a> <ul><li><a href="/wiki/CBFA2T2" title="CBFA2T2">CBFA2T2</a></li> <li><a href="/wiki/CBFA2T3" title="CBFA2T3">CBFA2T3</a></li> <li><a href="/wiki/RUNX1" title="RUNX1">RUNX1</a></li> <li><a href="/wiki/RUNX2" title="RUNX2">RUNX2</a></li> <li><a href="/wiki/RUNX3" title="RUNX3">RUNX3</a></li> <li><a href="/wiki/RUNX1T1" title="RUNX1T1">RUNX1T1</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible uncollapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(0)_Other_transcription_factors178" style="font-size:114%;margin:0 4em"><i> (0) Other transcription factors</i></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.2) HMGI(Y)</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HMGA" title="HMGA">HMGA</a> <ul><li><a href="/wiki/HMGA1" title="HMGA1">1</a></li> <li><a href="/wiki/HMGA2" title="HMGA2">2</a></li></ul></li> <li><a href="/wiki/HBP1" title="HBP1">HBP1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.3)</i> <a href="/wiki/Pocket_protein_family" title="Pocket protein family">Pocket domain</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Retinoblastoma_protein" title="Retinoblastoma protein">Rb</a></li> <li><a href="/wiki/Retinoblastoma-like_protein_1" title="Retinoblastoma-like protein 1">RBL1</a></li> <li><a href="/wiki/Retinoblastoma-like_protein_2" title="Retinoblastoma-like protein 2">RBL2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.5)</i> <a href="/wiki/Apetala_2" title="Apetala 2">AP-2</a><i>/</i><a href="/wiki/Ethylene-responsive_element_binding_protein" title="Ethylene-responsive element binding protein">EREBP</a><i>-related factors</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Apetala_2" title="Apetala 2">Apetala 2</a></li> <li><a href="/wiki/Ethylene-responsive_element_binding_protein" title="Ethylene-responsive element binding protein">EREBP</a></li> <li><a href="/wiki/B3_domain" title="B3 domain">B3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;"><i>(0.6) Miscellaneous</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>ARID</i> <ul><li><a href="/wiki/ARID1A" title="ARID1A">1A</a></li> <li><a href="/wiki/ARID1B" title="ARID1B">1B</a></li> <li><a href="/wiki/ARID2" title="ARID2">2</a></li> <li><a href="/wiki/ARID3A" title="ARID3A">3A</a></li> <li><a href="/wiki/ARID3B" title="ARID3B">3B</a></li> <li><a href="/wiki/ARID4A" title="ARID4A">4A</a></li></ul></li> <li><a href="/wiki/Catabolite_activator_protein" title="Catabolite activator protein">CAP</a></li> <li><i>IFI</i> <ul><li><a href="/wiki/IFI16" title="IFI16">16</a></li> <li><a href="/wiki/IFI35" title="IFI35">35</a></li></ul></li> <li><a href="/wiki/MLL_(gene)" class="mw-redirect" title="MLL (gene)">MLL</a> <ul><li><a href="/wiki/MLL2" class="mw-redirect" title="MLL2">2</a></li> <li><a href="/wiki/MLL3" class="mw-redirect" title="MLL3">3</a></li> <li><a href="/wiki/MLLT1" title="MLLT1">T1</a></li></ul></li> <li><a href="/wiki/MNDA" title="MNDA">MNDA</a></li> <li><i>NFY</i> <ul><li><a href="/wiki/NFYA" title="NFYA">A</a></li> <li><a href="/wiki/NFYB" title="NFYB">B</a></li> <li><a href="/wiki/NFYC" title="NFYC">C</a></li></ul></li> <li><a href="/wiki/Rho_factor" title="Rho factor">Rho</a>/<a href="/wiki/Sigma_factor" title="Sigma factor">Sigma</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background-color: AntiqueWhite"><div><i>see also <a href="/wiki/Template:Transcription_factor_and_coregulator_deficiencies" title="Template:Transcription factor and coregulator deficiencies">transcription factor/coregulator deficiencies</a></i></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=0" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div 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