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Towards Safe and Effective Hematopoietic Stem Cell Gene Therapy: Targeting Integration to Genomic Safe Harbors and Exploiting Endogenous microRNA to Regulate Transgene Expression | TARGETINGGENETHERAPY | Project | Fact sheet | FP7 | CORDIS | European Commission
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alt="" aria-hidden="true" width="75" height="75" /> </div> <div class="col-12 col-md-10 c-header-project__title-container"> <h1 class="c-header-project__title">Towards Safe and Effective Hematopoietic Stem Cell Gene Therapy: Targeting Integration to Genomic Safe Harbors and Exploiting Endogenous microRNA to Regulate Transgene Expression</h1> </div> </div> </div> <nav class="c-menu-project"> <div class="row"> <div class="col-12 c-menu-project__mobile"> <div class="c-collapse c-selector-collapse c-collapse--search"> <div class="c-collapse__item"> <div class="c-collapse__header"> <a href="#" class="c-collapse__link " role="button"> <span class="c-collapse__title">Fact Sheet</span> </a> </div> <div class="c-collapse__content c-collapse__content--no-padding"> <ul class="c-menu-project__menu" role="menu"> <li class="c-menu-project__menu-item c-menu-project__menu-item--active"> <a href="/project/id/249845" role="menuitem" class="c-menu-project__menu-link c-menu-project__menu-link--active" aria-current="page"> Fact Sheet </a> </li> <li class="c-menu-project__menu-item "> <a href="/project/id/249845/reporting" role="menuitem" class="c-menu-project__menu-link " aria-current=""> Reporting </a> </li> <li class="c-menu-project__menu-item "> <a href="/project/id/249845/results" role="menuitem" class="c-menu-project__menu-link " aria-current=""> Results </a> </li> </ul> </div> </div> </div> </div> <div class="col-12 c-menu-project__desktop"> <ul class="c-menu-project__menu" role="menu"> <li class="c-menu-project__menu-item"> <a href="/project/id/249845" role="menuitem" class="c-menu-project__menu-link c-menu-project__menu-link--active" aria-current="page"> Fact Sheet </a> </li> <li class="c-menu-project__menu-item"> <a href="/project/id/249845/reporting" role="menuitem" class="c-menu-project__menu-link " aria-current=""> Reporting </a> </li> <li class="c-menu-project__menu-item"> <a href="/project/id/249845/results" role="menuitem" class="c-menu-project__menu-link " aria-current=""> Results </a> </li> </ul> </div> </div> </nav> </section> <div id="pdfLoaded"></div> <div id="metaLoaded"></div> <div class="container container-full"> <div class="row t-row-print"> <aside class="col-12 col-lg-4 c-article__aside"> <div class="c-project-info" data-se="project__info"> <div class="c-project-info__title"> Project Information </div> <div class="c-project-info__content"> <div class="p-col-6"> <div class="c-project-info__acronym">TARGETINGGENETHERAPY</div> <div class="c-project-info__id"> Grant agreement ID: 249845 </div> <div class="c-project-info__status t-margin-top-20 t-margin-bottom-5"> Project closed </div> <div class="c-project-info__timeline t-padding-top-15"> <div class="row"> <div class="col-6"> <span class="c-project-info__label">Start date</span> 1 May 2010 </div> <div class="col-6 t-text-align-right"> <span class="c-project-info__label">End date</span> 31 January 2016 </div> </div> <div class="c-project-info__progress" aria-hidden="true"> <div class="c-project-info__percentage" style="width: 100%;"></div> </div> </div> </div> <div class="p-col-6"> <div class="c-project-info__fund"> <span class="c-project-info__label" id="projectInfoFundedUnder"> Funded under </span> <ul aria-labelledby="projectInfoFundedUnder" class="c-project-info__fund-list"> <li>Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)</li> </ul> </div> <div class="c-project-info__budget"> <div class="row"> <div class="col-6 align-self-center t-padding-top-15"> <div class="c-project-info__overall"> <span class="c-project-info__label">Total cost</span> € 2 500 000,00 </div> <div class="c-project-info__eu"> <span class="c-project-info__label">EU contribution</span> € 2 500 000,00 </div> </div> <div class="col-6 d-flex justify-content-center align-content-end"> <div class="c-project-info__donut-container"> <div class="c-chart"> <div class="c-chart-svg"> <svg width="100%" height="100%" viewbox="-1 -1 42 42" class="donut"> <circle class="c-chart-hole" cx="20" cy="20" r="15.91549430918954"></circle> <circle class="c-chart-ring" cx="20" cy="20" r="15.91549430918954"></circle> <circle class="c-chart-segment-cap" cx="20" cy="20" r="15.91549430918954" stroke-dasharray="100 0"></circle> <circle class="c-chart-segment" cx="20" cy="20" r="15.91549430918954" stroke-dasharray="100 0"></circle> </svg> </div> <div class="c-chart-details"> <div class="c-chart-details-one"> <span class="c-chart-details-color"></span> <span class="c-chart-details-text">2 500 000,00</span> </div> </div> </div> </div> </div> </div> </div> <div class="c-project-info__coord t-padding-top-15"> <span class="c-project-info__label"> Coordinated by </span> <p class="coordinated coordinated-name"> UNIVERSITA VITA-SALUTE SAN RAFFAELE <br/> <span class="fi fi-it flag-cordis" aria-hidden="true"></span> Italy </p> </div> </div> </div> </div> </aside> <article class="col-12 col-lg-8 order-lg-first"> <div id="c-objective" lang="en" class="c-factsheet__section "> <h2>Objective</h2> <p class="c-article__text"> Hematopoietic stem cell gene therapy has a tremendous potential to treat human disease. Yet, in conjunction with the first successful results in the clinic, severe adverse events linked to the gene transfer protocol were reported. Recently, we provided proof-of-principle of two new powerful strategies to improve the efficacy and safety of gene transfer: 1) regulating transgene expression by exploiting cellular microRNAs; 2) targeting integration at predetermined sites of the genome by forcing homologous recombination with designer Zinc finger nucleases. Here we will investigate the microRNA network regulating hematopoiesis and exploit the new knowledge to develop vectors with stringently controlled expression throughout the hematopoietic lineages. We will develop Zinc finger nuclease-based vectors that insert the transgene with high efficiency and specificity either downstream to its own endogenous promoter or into a safe genomic harbor that allows for robust expression without interference on the neighboring genes. By combining these strategies we will provide radically improved gene transfer platforms. Furthermore, we will exploit these technologies for the generation and genetic correction of induced pluripotent stem cells, providing a potentially unlimited source of patient-derived vector free gene corrected multipotent stem cells for future applications of regenerative medicine. The new gene therapy strategies will be tested in pre-clinical models of leukodystrophies and immunodeficiencies, for which we have extensive experience, and should enter a clinical trial for at least one such disease by the end of the proposed funding period. If successfully validated, the new strategies may eventually broaden the scope of gene therapy in medicine. </p> </div> <div class="c-factsheet__section"> <h3 id="fieldofscience2">Fields of science</h3> <ul aria-labelledby="fieldofscience2" class="c-factsheet__list bold-last"><li><span><a href="/search/en?q=%2Fproject%2Frelations%2Fcategories%2FeuroSciVoc%2Fcode%3D%27%2F21%2F%27&srt=%2Fproject%2FcontentUpdateDate%3Adecreasing">medical and health sciences</a><span class="fa-solid fa-angle-right c-factsheet__list-separator"></span></span><span><a href="/search/en?q=%2Fproject%2Frelations%2Fcategories%2FeuroSciVoc%2Fcode%3D%27%2F21%2F37%2F%27&srt=%2Fproject%2FcontentUpdateDate%3Adecreasing">medical biotechnology</a><span class="fa-solid fa-angle-right c-factsheet__list-separator"></span></span><span><a href="/search/en?q=%2Fproject%2Frelations%2Fcategories%2FeuroSciVoc%2Fcode%3D%27%2F21%2F37%2F165%2F%27&srt=%2Fproject%2FcontentUpdateDate%3Adecreasing">genetic engineering</a><span class="fa-solid fa-angle-right c-factsheet__list-separator"></span></span><span><a href="/search/en?q=%2Fproject%2Frelations%2Fcategories%2FeuroSciVoc%2Fcode%3D%27%2F21%2F37%2F165%2F659%2F%27&srt=%2Fproject%2FcontentUpdateDate%3Adecreasing">gene therapy</a></span></li><li><span><a href="/search/en?q=%2Fproject%2Frelations%2Fcategories%2FeuroSciVoc%2Fcode%3D%27%2F23%2F%27&srt=%2Fproject%2FcontentUpdateDate%3Adecreasing">natural sciences</a><span class="fa-solid fa-angle-right c-factsheet__list-separator"></span></span><span><a href="/search/en?q=%2Fproject%2Frelations%2Fcategories%2FeuroSciVoc%2Fcode%3D%27%2F23%2F53%2F%27&srt=%2Fproject%2FcontentUpdateDate%3Adecreasing">chemical sciences</a><span class="fa-solid fa-angle-right c-factsheet__list-separator"></span></span><span><a href="/search/en?q=%2Fproject%2Frelations%2Fcategories%2FeuroSciVoc%2Fcode%3D%27%2F23%2F53%2F365%2F%27&srt=%2Fproject%2FcontentUpdateDate%3Adecreasing">inorganic chemistry</a><span class="fa-solid fa-angle-right c-factsheet__list-separator"></span></span><span><a href="/search/en?q=%2Fproject%2Frelations%2Fcategories%2FeuroSciVoc%2Fcode%3D%27%2F23%2F53%2F365%2F72505310%2F%27&srt=%2Fproject%2FcontentUpdateDate%3Adecreasing">transition metals</a></span></li><li><span><a href="/search/en?q=%2Fproject%2Frelations%2Fcategories%2FeuroSciVoc%2Fcode%3D%27%2F21%2F%27&srt=%2Fproject%2FcontentUpdateDate%3Adecreasing">medical and health sciences</a><span class="fa-solid fa-angle-right c-factsheet__list-separator"></span></span><span><a href="/search/en?q=%2Fproject%2Frelations%2Fcategories%2FeuroSciVoc%2Fcode%3D%27%2F21%2F37%2F%27&srt=%2Fproject%2FcontentUpdateDate%3Adecreasing">medical biotechnology</a><span class="fa-solid fa-angle-right c-factsheet__list-separator"></span></span><span><a href="/search/en?q=%2Fproject%2Frelations%2Fcategories%2FeuroSciVoc%2Fcode%3D%27%2F21%2F37%2F163%2F%27&srt=%2Fproject%2FcontentUpdateDate%3Adecreasing">cells technologies</a><span class="fa-solid fa-angle-right c-factsheet__list-separator"></span></span><span><a href="/search/en?q=%2Fproject%2Frelations%2Fcategories%2FeuroSciVoc%2Fcode%3D%27%2F21%2F37%2F163%2F657%2F%27&srt=%2Fproject%2FcontentUpdateDate%3Adecreasing">stem cells</a></span></li><li><span><a href="/search/en?q=%2Fproject%2Frelations%2Fcategories%2FeuroSciVoc%2Fcode%3D%27%2F23%2F%27&srt=%2Fproject%2FcontentUpdateDate%3Adecreasing">natural sciences</a><span class="fa-solid fa-angle-right c-factsheet__list-separator"></span></span><span><a href="/search/en?q=%2Fproject%2Frelations%2Fcategories%2FeuroSciVoc%2Fcode%3D%27%2F23%2F49%2F%27&srt=%2Fproject%2FcontentUpdateDate%3Adecreasing">biological sciences</a><span class="fa-solid fa-angle-right c-factsheet__list-separator"></span></span><span><a href="/search/en?q=%2Fproject%2Frelations%2Fcategories%2FeuroSciVoc%2Fcode%3D%27%2F23%2F49%2F337%2F%27&srt=%2Fproject%2FcontentUpdateDate%3Adecreasing">genetics</a><span class="fa-solid fa-angle-right c-factsheet__list-separator"></span></span><span><a href="/search/en?q=%2Fproject%2Frelations%2Fcategories%2FeuroSciVoc%2Fcode%3D%27%2F23%2F49%2F337%2F1025%2F%27&srt=%2Fproject%2FcontentUpdateDate%3Adecreasing">genomes</a></span></li></ul> </div> <div class="c-factsheet__section"> <h3 id="fundedunderprogrammes">Programme(s)</h3> <ul aria-labelledby="fundedunderprogrammes" class="c-factsheet__list"> <li class=""> <a href="/programme/id/FP7-IDEAS-ERC/en"> FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) </a> </li> </ul> </div> <div class="c-factsheet__section"> <h3 id="topicslist">Topic(s)</h3> <ul aria-labelledby="tpoicslist" class="c-factsheet__list"> <li> <a href="/programme/id/FP7_ERC-AG-LS7/en"> ERC-AG-LS7 - ERC Advanced Grant - Diagnostic tools, therapies and public health </a> </li> </ul> </div> <div class="c-factsheet__section"> <h3>Call for proposal</h3> <p> <span>ERC-2009-AdG</span><br /> <a href="/search/en?q=contenttype='project' AND /project/relations/associations/relatedSubCall/call/identifier='ERC-2009-AdG'&p=1&num=10&srt=Relevance:decreasing"> See other projects for this call </a> </p> </div> <div class="c-factsheet__section"> <h3>Funding Scheme</h3> <a href="/search/en?q=/project/relations/categories/projectFundingSchemeCategory/code='ERC-AG'&p=1&num=10&srt=Relevance:decreasing"> ERC-AG - ERC Advanced Grant </a> </div> <div class="c-factsheet__map"> <div id="WidgetPlaceHolder"></div> <script src="https://cordis.europa.eu/datalab/visualisations/widget/js/widgetLoader.js" type="text/javascript" async="true" charset="utf-8" data-pid="249845" data-target="WidgetPlaceHolder" data-displaymeta="off" data-fullscreen="on" data-css="/datalab/visualisations/widget/css/widgetMapContrib.css" data-type="project-contrib-map" data-lv="en" data-root-url="https://cordis.europa.eu/datalab" data-apikey="340e55f9-f2df-496a-9e06-99d918abede7"></script> </div> <div class="c-factsheet__section"> <h3> Host institution </h3> <div class="t-margin-bottom-20" data-se="org_coordinator"> <div class="c-organisation c-part-info "> <div class="row"> <div class="col-10 col-lg-1 t-padding-right-0"> <div class="c-part-info__icon"> <span class="fa-solid fa-building" aria-hidden="true"></span> </div> </div> <div class="col-2 col-lg-1 order-lg-last c-part-info__expand-btn-container"> </div> <div class="col-12 col-lg-10"> <div class="row"> <div class="col-12 col-lg-8"> <div class="c-part-info__title"> UNIVERSITA VITA-SALUTE SAN RAFFAELE </div> </div> <div class="col-md-4"> <div class="c-part-info__subtitle c-part-info__subtitle-alt"> EU contribution </div> <div class="c-part-info__content "> € 910 800,00 </div> </div> </div> <div class="c-part-info__extra "> <div class="row"> <div class="col-12 col-lg-8 order-2 order-lg-1"> <div> <div class="c-part-info__subtitle"> Address </div> <div class="c-part-info__content"> VIA OLGETTINA 58 <br> 20132 Milano <br><span class="fi fi-it" aria-hidden="true"></span> Italy <div tabindex="0" class="c-tooltip d-inline-block t-margin-left-10"> <span class="datalab-go-to-icon" data-organizationrcn="1906198"> <span class="c-collapse__tooltip" tabindex="0"> <span class="fa-solid fa-map-location-dot c-tooltip__href"></span> <div class="c-collapse__tooltip-in" aria-role="tooltip"> <p>See on map</p> <span aria-hidden="true"></span> </div> </span> </span> </div> </div> </div> <div> <div class="c-part-info__subtitle">Region</div> <div class="c-part-info c-part-info__content"> <span class="c-part-info__content region-part"> Nord-Ovest <span class="fa-solid fa-angle-right c-factsheet__list-separator"></span> </span> <span class="c-part-info__content region-part"> Lombardia <span class="fa-solid fa-angle-right c-factsheet__list-separator"></span> </span> <span class="c-part-info__content region-part"> Milano </span> </div> </div> <div> <div class="c-part-info__subtitle">Activity type</div> <div class="c-part-info__content">Higher or Secondary Education Establishments</div> </div> <div> <div class="c-part-info__subtitle"> Principal investigator </div> <div class="c-part-info__content"> Luigi Naldini (Prof.) </div> </div> <div> <div class="c-part-info__subtitle"> Administrative Contact </div> <div class="c-part-info__content"> Maria Rosa Pedrazzi (Dr.) </div> </div> <div class="c-part-info__subtitle">Links</div> <div> <span class="c-part-info__content"> <a href="https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/contact-form/PROJECT/999854467/249845" class="t-margin-right-15" target="_blank" rel="noopener noreferrer"> Contact the organisation <span class="sr-only">Opens in new window</span><span class="fa-solid fa-up-right-from-square"></span></a> </a> </span> <span class="c-part-info__content"> <a href="http://www.unihsr.it" target="_blank" rel="noopener noreferrer"> Website <span class="sr-only">Opens in new window</span><span class="fa-solid fa-up-right-from-square"></span></a> </a> </span> <div class="c-part-info__content"> <a href="/datalab/visualisations/vis.php?lv=en&oid=999854467"> HORIZON collaboration network <span class="sr-only">Opens in new window</span><span class="fa-solid fa-handshake"></span></a> </a> </div> </div> </div> <div class="col-12 col-lg-4 order-1 order-lg-2"> <div class="c-part-info__subtitle"> Total cost </div> <div class="c-part-info__content "> No data </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="c-factsheet__section"> <h3>Beneficiaries (3)</h3> <div class="c-organizations-list"> <div class="row"> <div class="col-4 c-organizations-list__col-srtal "> <button class="c-organizations-list__btn c-organizations-list__btn-srt" data-sort="abc"> Sort alphabetically </button> </div> <div class="col-4 c-organizations-list__col-sorteuc"> <button class="c-organizations-list__btn c-organizations-list__btn-srt" data-sort="contrib"> Sort by EU Contribution </button> </div> <div class="col-4 c-organizations-list__col-exp"> <button class="c-organizations-list__btn orgExpandAll" data-status="closed"> <span class="">Expand all</span> <span class="d-none">Collapse all</span> </button> </div> </div> <div class="row org-list"> <div class="col-12 c-organizations-list__item" data-title="UNIVERSITA VITA-SALUTE SAN RAFFAELE" data-contribution="910800" data-neteccontribution="" > <div class="c-organisation c-part-info expandable "> <div class="row"> <div class="col-10 col-lg-1 t-padding-right-0"> <div class="c-part-info__icon"> <span class="fa-solid fa-building" aria-hidden="true"></span> </div> </div> <div class="col-2 col-lg-1 order-lg-last c-part-info__expand-btn-container"> <button aria-label="Expand card extra information" class="c-part-info__expand-btn" aria-expanded="false"> <span aria-hidden="true" class="fa-solid fa-caret-down"></span> <span aria-hidden="true" class="fa-solid fa-caret-up d-none"></span> </button> </div> <div class="col-12 col-lg-10"> <div class="row"> <div class="col-12 col-lg-8"> <div class="c-part-info__title"> UNIVERSITA VITA-SALUTE SAN RAFFAELE <div class="c-part-info__country c-part-info__country-alt"> <span aria-hidden="true" class="fi fi-it"></span> Italy </div> </div> </div> <div class="col-md-4"> <div class="c-part-info__subtitle c-part-info__subtitle-alt"> EU contribution </div> <div class="c-part-info__content "> € 910 800,00 </div> </div> </div> <div class="c-part-info__extra d-none"> <div class="row"> <div class="col-12 col-lg-8 order-2 order-lg-1"> <div> <div class="c-part-info__subtitle"> Address </div> <div class="c-part-info__content"> VIA OLGETTINA 58 <br> 20132 Milano <div tabindex="0" class="c-tooltip d-inline-block t-margin-left-10"> <span class="datalab-go-to-icon" data-organizationrcn="1906198"> <span class="c-collapse__tooltip" tabindex="0"> <span class="fa-solid fa-map-location-dot c-tooltip__href"></span> <div class="c-collapse__tooltip-in" aria-role="tooltip"> <p>See on map</p> <span aria-hidden="true"></span> </div> </span> </span> </div> </div> </div> <div> <div class="c-part-info__subtitle">Region</div> <div class="c-part-info c-part-info__content"> <span class="c-part-info__content region-part"> Nord-Ovest <span class="fa-solid fa-angle-right c-factsheet__list-separator"></span> </span> <span class="c-part-info__content region-part"> Lombardia <span class="fa-solid fa-angle-right c-factsheet__list-separator"></span> </span> <span class="c-part-info__content region-part"> Milano </span> </div> </div> <div> <div class="c-part-info__subtitle">Activity type</div> <div class="c-part-info__content">Higher or Secondary Education Establishments</div> </div> <div> <div class="c-part-info__subtitle"> Principal investigator </div> <div class="c-part-info__content"> Luigi Naldini (Prof.) </div> </div> <div> <div class="c-part-info__subtitle"> Administrative Contact </div> <div class="c-part-info__content"> Maria Rosa Pedrazzi (Dr.) </div> </div> <div class="c-part-info__subtitle">Links</div> <div> <span class="c-part-info__content"> <a href="https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/contact-form/PROJECT/999854467/249845" class="t-margin-right-15" target="_blank" rel="noopener noreferrer"> Contact the organisation <span class="sr-only">Opens in new window</span><span class="fa-solid fa-up-right-from-square"></span></a> </a> </span> <span class="c-part-info__content"> <a href="http://www.unihsr.it" target="_blank" rel="noopener noreferrer"> Website <span class="sr-only">Opens in new window</span><span class="fa-solid fa-up-right-from-square"></span></a> </a> </span> <div class="c-part-info__content"> <a href="/datalab/visualisations/vis.php?lv=en&oid=999854467"> HORIZON collaboration network <span class="sr-only">Opens in new window</span><span class="fa-solid fa-handshake"></span></a> </a> </div> </div> </div> <div class="col-12 col-lg-4 order-1 order-lg-2"> <div class="c-part-info__subtitle"> Total cost </div> <div class="c-part-info__content "> No data </div> </div> </div> </div> </div> </div> </div> </div> <div class="col-12 c-organizations-list__item" data-title="FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR" data-contribution="493002.13" data-neteccontribution="" > <div class="c-organisation c-part-info expandable "> <div class="row"> <div class="col-10 col-lg-1 t-padding-right-0"> <div class="c-part-info__icon"> <span class="fa-solid fa-building" aria-hidden="true"></span> </div> </div> <div class="col-2 col-lg-1 order-lg-last c-part-info__expand-btn-container"> <button aria-label="Expand card extra information" class="c-part-info__expand-btn" aria-expanded="false"> <span aria-hidden="true" class="fa-solid fa-caret-down"></span> <span aria-hidden="true" class="fa-solid fa-caret-up d-none"></span> </button> </div> <div class="col-12 col-lg-10"> <div class="row"> <div class="col-12 col-lg-8"> <div class="c-part-info__title c-part-info__title--terminated"> FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR <span class="c-collapse__tooltip" tabindex="0"> <span class="fa-solid fa-circle-info"></span> <div class="c-collapse__tooltip-in" aria-role="tooltip"> <p>Participation ended</p> <span aria-hidden="true"></span> </div> </span> <div class="c-part-info__country c-part-info__country-alt"> <span aria-hidden="true" class="fi fi-it"></span> Italy </div> </div> </div> <div class="col-md-4"> <div class="c-part-info__subtitle c-part-info__subtitle-alt"> EU contribution </div> <div class="c-part-info__content c-part-info__content--terminated"> € 493 002,13 </div> </div> </div> <div class="c-part-info__extra d-none"> <div class="row"> <div class="col-12 col-lg-8 order-2 order-lg-1"> <div> <div class="c-part-info__subtitle"> Address </div> <div class="c-part-info__content"> Via Olgettina 60 <br> 20132 MILANO <div tabindex="0" class="c-tooltip d-inline-block t-margin-left-10"> <span class="datalab-go-to-icon" data-organizationrcn="1906647"> <span class="c-collapse__tooltip" tabindex="0"> <span class="fa-solid fa-map-location-dot c-tooltip__href"></span> <div class="c-collapse__tooltip-in" aria-role="tooltip"> <p>See on map</p> <span aria-hidden="true"></span> </div> </span> </span> </div> </div> </div> <div> <div class="c-part-info__subtitle">Region</div> <div class="c-part-info c-part-info__content"> <span class="c-part-info__content region-part"> Nord-Ovest <span class="fa-solid fa-angle-right c-factsheet__list-separator"></span> </span> <span class="c-part-info__content region-part"> Lombardia <span class="fa-solid fa-angle-right c-factsheet__list-separator"></span> </span> <span class="c-part-info__content region-part"> Milano </span> </div> </div> <div> <div class="c-part-info__subtitle">Activity type</div> <div class="c-part-info__content">Research Organisations</div> </div> <div> <div class="c-part-info__subtitle"> Administrative Contact </div> <div class="c-part-info__content"> Mario Valsecchi (Mr.) </div> </div> <div class="c-part-info__subtitle">Links</div> <div> <span class="c-part-info__content"> <a href="https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/contact-form/PROJECT/999614392/249845" class="t-margin-right-15" target="_blank" rel="noopener noreferrer"> Contact the organisation <span class="sr-only">Opens in new window</span><span class="fa-solid fa-up-right-from-square"></span></a> </a> </span> <span class="c-part-info__content"> <a href="http://www.sanraffaele.org" target="_blank" rel="noopener noreferrer"> Website <span class="sr-only">Opens in new window</span><span class="fa-solid fa-up-right-from-square"></span></a> </a> </span> <div class="c-part-info__content"> <a href="/datalab/visualisations/vis.php?lv=en&oid=999614392"> HORIZON collaboration network <span class="sr-only">Opens in new window</span><span class="fa-solid fa-handshake"></span></a> </a> </div> </div> </div> <div class="col-12 col-lg-4 order-1 order-lg-2"> <div class="c-part-info__subtitle"> Total cost </div> <div class="c-part-info__content c-part-info__content--terminated"> No data </div> </div> </div> </div> </div> </div> </div> </div> <div class="col-12 c-organizations-list__item" data-title="OSPEDALE SAN RAFFAELE SRL" data-contribution="1096197.87" data-neteccontribution="" > <div class="c-organisation c-part-info expandable "> <div class="row"> <div class="col-10 col-lg-1 t-padding-right-0"> <div class="c-part-info__icon"> <span class="fa-solid fa-building" aria-hidden="true"></span> </div> </div> <div class="col-2 col-lg-1 order-lg-last c-part-info__expand-btn-container"> <button aria-label="Expand card extra information" class="c-part-info__expand-btn" aria-expanded="false"> <span aria-hidden="true" class="fa-solid fa-caret-down"></span> <span aria-hidden="true" class="fa-solid fa-caret-up d-none"></span> </button> </div> <div class="col-12 col-lg-10"> <div class="row"> <div class="col-12 col-lg-8"> <div class="c-part-info__title"> OSPEDALE SAN RAFFAELE SRL <div class="c-part-info__country c-part-info__country-alt"> <span aria-hidden="true" class="fi fi-it"></span> Italy </div> </div> </div> <div class="col-md-4"> <div class="c-part-info__subtitle c-part-info__subtitle-alt"> EU contribution </div> <div class="c-part-info__content "> € 1 096 197,87 </div> </div> </div> <div class="c-part-info__extra d-none"> <div class="row"> <div class="col-12 col-lg-8 order-2 order-lg-1"> <div> <div class="c-part-info__subtitle"> Address </div> <div class="c-part-info__content"> VIA OLGETTINA 60 <br> 20132 Milano <div tabindex="0" class="c-tooltip d-inline-block t-margin-left-10"> <span class="datalab-go-to-icon" data-organizationrcn="1949505"> <span class="c-collapse__tooltip" tabindex="0"> <span class="fa-solid fa-map-location-dot c-tooltip__href"></span> <div class="c-collapse__tooltip-in" aria-role="tooltip"> <p>See on map</p> <span aria-hidden="true"></span> </div> </span> </span> </div> </div> </div> <div> <div class="c-part-info__subtitle">Region</div> <div class="c-part-info c-part-info__content"> <span class="c-part-info__content region-part"> Nord-Ovest <span class="fa-solid fa-angle-right c-factsheet__list-separator"></span> </span> <span class="c-part-info__content region-part"> Lombardia <span class="fa-solid fa-angle-right c-factsheet__list-separator"></span> </span> <span class="c-part-info__content region-part"> Milano </span> </div> </div> <div> <div class="c-part-info__subtitle">Activity type</div> <div class="c-part-info__content">Private for-profit entities (excluding Higher or Secondary Education Establishments)</div> </div> <div> <div class="c-part-info__subtitle"> Administrative Contact </div> <div class="c-part-info__content"> Maria Rosa Pedrazzi (Dr.) </div> </div> <div class="c-part-info__subtitle">Links</div> <div> <span class="c-part-info__content"> <a href="https://ec.europa.eu/info/funding-tenders/opportunities/portal/screen/contact-form/PROJECT/953176030/249845" class="t-margin-right-15" target="_blank" rel="noopener noreferrer"> Contact the organisation <span class="sr-only">Opens in new window</span><span class="fa-solid fa-up-right-from-square"></span></a> </a> </span> <span class="c-part-info__content"> <a href="http://www.hsr.it" target="_blank" rel="noopener noreferrer"> Website <span class="sr-only">Opens in new window</span><span class="fa-solid fa-up-right-from-square"></span></a> </a> </span> <div class="c-part-info__content"> <a href="/datalab/visualisations/vis.php?lv=en&oid=953176030"> HORIZON collaboration network <span class="sr-only">Opens in new window</span><span class="fa-solid fa-handshake"></span></a> </a> </div> </div> </div> <div class="col-12 col-lg-4 order-1 order-lg-2"> <div class="c-part-info__subtitle"> Total cost </div> <div class="c-part-info__content "> No data </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </article> </div> </div> <div class="container container-full"> <section class="o-section"> <div class="row"> <div 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id="booklet-completion-modal-success"> <div class="c-modal__overlay"> <div class="c-modal__dialog" role="dialog"> <div class="c-modal__dialog-header"> <div class="c-modal__dialog-header-buttons"> <button class="c-modal__dialog-header-button c-modal__dialog-header-button--close" aria-label="Close dialog"> <span aria-hidden="true" class="fa-solid fa-xmark"></span> </button> </div> </div> <div class="c-modal__dialog-body"> <h2 class="o-title o-title--h2">Your booklet is ready</h2> <div class="c-booklet-modal__text c-selector-booklet-modal-txt"><p>Your booklet is ready.</p><p>Your booklet {{ title }} generated on {{ timestamp }} is available for download.</p><p>The file will remain available for {{ hours }} hours, or until you close your browser.</p></div> <a class="o-btn o-btn--large c-btn--pdf c-link-btn c-selector-booklet-modal-dl-btn"> Download booklet </a> <a class="o-btn o-btn--light c-link-btn" href="/booklet"> View all booklets </a> </div> </div> </div> </div> <div class="c-modal" id="booklet-completion-modal-error"> <div class="c-modal__overlay"> <div class="c-modal__dialog" role="dialog"> <div class="c-modal__dialog-header"> <div class="c-modal__dialog-header-buttons"> <button class="c-modal__dialog-header-button c-modal__dialog-header-button--close" aria-label="Close dialog"> <span aria-hidden="true" class="fa-solid fa-xmark"></span> </button> </div> </div> <div class="c-modal__dialog-body"> <h2 class="o-title o-title--h2 c-selector-booklet-modal-failure-title">The generation of your booklet {{ title }} has failed</h2> <div class="c-booklet-modal__text c-selector-booklet-modal-failure-txt">The generation of your booklet {{ title }} has failed. Please check your My Booklet page for more information</div> <a class="o-btn o-btn--light c-link-btn" href="/booklet"> View all booklets </a> </div> </div> </div> </div> <div id="envUrl" data-env="https://cordis.europa.eu"></div> <div id="uiLanguage" data-lang=en></div> <div id="contentLanguage" data-lang=en></div> <div id="surveyDoCheck" data-survey-do-check="false"></div> <div id="surveyYear" data-survey-year="2023"></div> <div position="bottom-center" class="p-element p-toaster"> <div class="p-toast p-component p-toast-bottom-center"> <div class="p-element"> <div class="p-toast-message" style="transform: translateY(0px); opacity: 1;"> <div role="alert" aria-live="assertive" aria-atomic="true" class="p-toast-message-content"> <div class="p-toast-message-text"> <div class="p-toast-summary" data-bookletok="Item added to booklet" data-bookletnok="Item could not be added" data-cookies="Your cookie preference has been updated." ></div> <div class="p-toast-detail"></div> </div> <span class="p-toaster-icon"></span> <button type="button" class="p-ripple p-element p-toast-icon-close p-link" aria-label="Close"> <span class="fa-solid fa-xmark"></span> </button> </div> </div> </div> </div> </div> <script src="/assets/libs/op_piwik_pro_production.js" type="text/javascript"></script> <noscript> <iframe title="analytic" src="//opanalytics.containers.piwik.pro/f0483949-d65d-4b24-a9ff-82b5105d06fe/noscript.html" height="0" width="0" style="display:none;visibility:hidden" aria-hidden="true"></iframe> </noscript> <script type="application/json">{ "utility": "globan", "renderTo": "#globan-here", "lang": "en", "theme": "dark", "logo": true, "link": true, "mode": false, "zindex" : 40 }</script> <script src="/build/libs/moment.min.js"></script> <script src="/build/libs/ecl-ec.js"></script> <script> ECL.autoInit(); </script> </body> </html>