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<div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Benign small tumor on the finger or toe of an infant</div> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Medical condition</div><style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox ib-medical-condition"><tbody><tr><th colspan="2" class="infobox-above" style="background:#ccc">Infantile digital fibromatosis</th></tr><tr><th scope="row" class="infobox-label">Other names</th><td class="infobox-data">Inclusion body fibromatosis, Infantile digital myofibroblastoma, Reye's tumor</td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Medical_specialty" title="Medical specialty">Specialty</a></th><td class="infobox-data"><a href="/wiki/Pediatrics" title="Pediatrics">Pediatrics</a>, <a href="/wiki/Dermatology" title="Dermatology">Dermatology</a></td></tr><tr><th scope="row" class="infobox-label">Usual onset</th><td class="infobox-data">Typically at birth or infancy</td></tr><tr><th scope="row" class="infobox-label">Causes</th><td class="infobox-data">Unknown</td></tr><tr><th scope="row" class="infobox-label"><a href="/wiki/Prognosis" title="Prognosis">Prognosis</a></th><td class="infobox-data">Excellent</td></tr><tr><th scope="row" class="infobox-label">Frequency</th><td class="infobox-data">Rare</td></tr></tbody></table> <p><b>Infantile digital fibromatosis</b> (<b>IDF</b>), also termed <b>inclusion body fibromatosis</b> or <b>Reye's tumor</b>, usually occurs as a single, small, <a href="/wiki/Asymptomatic" title="Asymptomatic">asymptomatic</a>, <a href="/wiki/Nodule_(medicine)" title="Nodule (medicine)">nodule</a> in the <a href="/wiki/Dermis" title="Dermis">dermis</a> on a finger or toe<sup id="cite_ref-Fitz2_1-0" class="reference"><a href="#cite_note-Fitz2-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> of infants and young children.<sup id="cite_ref-pmid18830128_2-0" class="reference"><a href="#cite_note-pmid18830128-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> IMF is a rare disorder with approximately 200 cases reported in the medical literature as of 2021.<sup id="cite_ref-pmid33565473_3-0" class="reference"><a href="#cite_note-pmid33565473-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> The World Health Organization in 2020 classified these nodules as a specific <a href="/wiki/Benign_tumor" title="Benign tumor">benign tumor</a> type in the category of <a href="/wiki/Fibroblastic_and_myofibroblastic_tumors" title="Fibroblastic and myofibroblastic tumors">fibroblastic and myofibroblastic tumors</a>.<sup id="cite_ref-pmid33179614_4-0" class="reference"><a href="#cite_note-pmid33179614-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> IDF was first described by the Australian pathologist <a href="/wiki/Douglas_Reye" title="Douglas Reye">Douglas Reye</a> in 1965.<sup id="cite_ref-pmid14322942_5-0" class="reference"><a href="#cite_note-pmid14322942-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>IDF consists of an overgrowth of spindle-shaped cells in a <a href="/wiki/Collagen" title="Collagen">collagen</a> fiber-rich background located in the dermis (i.e. the layer of skin between the <a href="/wiki/Epidermis" title="Epidermis">epidermis</a> and <a href="/wiki/Subcutaneous_tissue" title="Subcutaneous tissue">subcutaneous tissue</a>) but may extend into the subcutaneous tissue. These spindle-shaped cells contain distinctive <a href="/wiki/Inclusion_bodies" title="Inclusion bodies">inclusion bodies</a> within their <a href="/wiki/Cytoplasm" title="Cytoplasm">cytoplasm</a> that greatly help in distinguishing IDF from other fibrous skin diseases. These inclusions are composed of densely packed <a href="/wiki/Vimentin" title="Vimentin">vimentin</a> and <a href="/wiki/Actin" title="Actin">actin</a> <a href="/wiki/Protein_filament" title="Protein filament">filaments</a>.<sup id="cite_ref-pmid34394250_6-0" class="reference"><a href="#cite_note-pmid34394250-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>IDF lesions are usually painless and have a tendency to regress spontaneously. Consequently, the current recommended treatment for IDF nodules is conservative observation.<sup id="cite_ref-pmid33565473_3-1" class="reference"><a href="#cite_note-pmid33565473-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> If the lesions cause local deformities and/or functional impairments or continue to increase in size over long observation periods, surgical removal is recommended. However, surgically removed IDF lesions have had high rates of recurrence and this surgery may cause post-operative digital deformities.<sup id="cite_ref-pmid34394250_6-1" class="reference"><a href="#cite_note-pmid34394250-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Presentation">Presentation</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Infantile_digital_fibromatosis&action=edit&section=1" title="Edit section: Presentation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>IDF typically presents as a solitary painless, smooth, flesh-colored to red, dome-shaped nodule located on the dorsal or lateral aspect of a finger or toe but sparing the thumb or great toe;<sup id="cite_ref-pmid33565473_3-2" class="reference"><a href="#cite_note-pmid33565473-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> they occur principally in the first two years of life with about one-third of cases having a lesion since birth.<sup id="cite_ref-pmid34394250_6-2" class="reference"><a href="#cite_note-pmid34394250-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> However: <b>1)</b> lesions with appearances similar to, and diagnosed as, IPF have been described in extra digital sites such as the arm, breast, tongue, thigh,<sup id="cite_ref-pmid33565473_3-3" class="reference"><a href="#cite_note-pmid33565473-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> and chest;<sup id="cite_ref-pmid34394250_6-3" class="reference"><a href="#cite_note-pmid34394250-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> <b>2)</b> unusual cases have presented with multiple lesions, i.e. 2–3, uncommonly 7–15, and one case with 74 lesions in a 2018 review study;<sup id="cite_ref-pmid29780440_7-0" class="reference"><a href="#cite_note-pmid29780440-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> <b>3)</b> cases have been reported in children up to the age 10 and one case was reported in a 52-year-old adult;<sup id="cite_ref-pmid27684985_8-0" class="reference"><a href="#cite_note-pmid27684985-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> <b>4)</b> the lesions are typically smaller than 2 cm in maximum diameter<sup id="cite_ref-pmid33565473_3-4" class="reference"><a href="#cite_note-pmid33565473-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> but rarely have been tumor-sized, e.g. 4.5 cm;<sup id="cite_ref-pmid34394250_6-4" class="reference"><a href="#cite_note-pmid34394250-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> <b>5)</b> the lesions, particularly when larger-sized, may be painful and/or compromise the functions of nearby joints and digits;<sup id="cite_ref-pmid29780440_7-1" class="reference"><a href="#cite_note-pmid29780440-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> and <b>6)</b> the lesions occasionally invade the <a href="/wiki/Periosteum" title="Periosteum">periosteum</a> and erode a nearby bone.<sup id="cite_ref-pmid34394250_6-5" class="reference"><a href="#cite_note-pmid34394250-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Pathology">Pathology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Infantile_digital_fibromatosis&action=edit&section=2" title="Edit section: Pathology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Microscopic <a href="/wiki/Histopathological" class="mw-redirect" title="Histopathological">histopathological</a> analyses of appropriately <a href="/wiki/Staining" title="Staining">dye-stained</a> IDF tissues typically show a non-encapsulated small tumor composed of bundles of uniform spindle-shaped cells that combine physical features of <a href="/wiki/Fibroblasts" class="mw-redirect" title="Fibroblasts">fibroblasts</a> (the most common cell type in connective tissue) with those of <a href="/wiki/Myofibroblast" title="Myofibroblast">myofibroblasts</a> (contractile, spindle-shaped cells that are identifiable by their expression of <a href="/wiki/Smooth_muscle#actin" title="Smooth muscle">α-smooth muscle actin</a>) in a background of collagen fibers.<sup id="cite_ref-pmid33565473_3-5" class="reference"><a href="#cite_note-pmid33565473-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> In <a href="/wiki/H%26E_stain" title="H&E stain">hematoxylin and eosin-stained</a> tissues, the spindle-shaped cells have pale eosinophilic (i.e. red or pink due to uptake of eosin) cytoplasm with plump and elongated <a href="/wiki/Cell_nucleus" title="Cell nucleus">nuclei</a> composed of granulated (i.e. having many small, distinct parts) <a href="/wiki/Chromatin" title="Chromatin">chromatin</a>. The most <a href="/wiki/Pathognomonic" title="Pathognomonic">pathognomonic</a> (i.e. indicative of a particular disease) feature of these cells is the presence of <a href="/wiki/Cytoplasmic" class="mw-redirect" title="Cytoplasmic">cytoplasmic</a> perinuclear inclusion bodies which usually are small, round, pale pink bodies on hematoxylin and eosin staining that often indent their parent cells' nuclei. These inclusions are composed of densely packed <a href="/wiki/Vimentin" title="Vimentin">vimentin</a> and <a href="/wiki/Actin" title="Actin">actin</a> filaments. Newer tumors show relatively abundant inclusion bodies and scarce collagen fibers while older tumors show few or no detectable inclusion bodies and abundant collagen fibers. <a href="/wiki/Immunohistochemistry" title="Immunohistochemistry">Immunohistochemical analyses</a> show that the spindle-shaped cells typically express α-smooth muscle actin, <a href="/wiki/Calponin" title="Calponin">calponin</a>, <a href="/wiki/Desmin" title="Desmin">desmin</a>, and <a href="/wiki/CD99" title="CD99">CD99</a> proteins<sup id="cite_ref-pmid27684985_8-1" class="reference"><a href="#cite_note-pmid27684985-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> but not <a href="/wiki/S100_protein" title="S100 protein">S100 protein</a> or <a href="/wiki/Glial_fibrillary_acidic_protein" title="Glial fibrillary acidic protein">glial fibrillary acidic protein</a>.<sup id="cite_ref-pmid34394250_6-6" class="reference"><a href="#cite_note-pmid34394250-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Diagnosis">Diagnosis</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Infantile_digital_fibromatosis&action=edit&section=3" title="Edit section: Diagnosis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The diagnosis of IDF is usually based on its presentation in newborn or young infants and <a href="/wiki/Biopsy" title="Biopsy">biopsy</a> or <a href="/wiki/Fine_needle_aspirate" class="mw-redirect" title="Fine needle aspirate">fine needle aspirate</a> analyses of the tumors' pathology.<sup id="cite_ref-pmid29780440_7-2" class="reference"><a href="#cite_note-pmid29780440-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> These analyses should show the presence of spindle-shaped cells bearing eosinophilic paranuclear inclusions consisting of actin and vimentin filaments, which, if necessary, can be confirmed by <a href="/wiki/Immunofluorescence" title="Immunofluorescence">immunofluorescence</a> staining of the filaments.<sup id="cite_ref-pmid34394250_6-7" class="reference"><a href="#cite_note-pmid34394250-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Inclusions may not be evident in older lesions stained with hematoxylin and eosin but may be apparent when stained with other reagents such as the <a href="/wiki/Masson%27s_trichrome_stain" title="Masson's trichrome stain">Masson's trichrome stain</a>,<sup id="cite_ref-pmid34394250_6-8" class="reference"><a href="#cite_note-pmid34394250-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Phosphotungstic_acid-haematoxylin_stain" title="Phosphotungstic acid-haematoxylin stain">phosphotungstic acid-haematoxylin stain</a>, elastic <a href="/wiki/Van_Gieson%27s_stain" title="Van Gieson's stain">Van Gieson's stain</a>, or <a href="/wiki/Trichrome_staining#Procedure" title="Trichrome staining">Lendrum's phloxine-tartrazine stain</a>.<sup id="cite_ref-pmid34394250_6-9" class="reference"><a href="#cite_note-pmid34394250-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Demonstration of these filaments is not necessary for a diagnosis of IMF if the clinical picture and other histological findings are consistent with the disorder.<sup id="cite_ref-pmid29780440_7-3" class="reference"><a href="#cite_note-pmid29780440-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Findings of one or a few usually small lesions centered in the dermis of a digit consisting of spindle-shaped cells and expressing α-smooth muscle actin, desmin, and calponin proteins would support the diagnosis of IDF.<sup id="cite_ref-pmid27684985_8-2" class="reference"><a href="#cite_note-pmid27684985-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p><a href="/wiki/Infantile_myofibromatosis" title="Infantile myofibromatosis">Infantile myofibromatosis</a> (IMF) is, like IDF, a disease in which benign tumors develop primarily in the fingers and toes of newborns and infants and consists of spindle-shaped cells in a collagen fibrous background. IDF was once regarded as a sub-type of infantile myofibromatosis. However, IMF tumors can be far more aggressive than IDF lesions and consist of cells that do not have paranuclear inclusions.<sup id="cite_ref-pmid18830128_2-1" class="reference"><a href="#cite_note-pmid18830128-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> The <a href="/wiki/World_Health_Organization" title="World Health Organization">World Health Organization</a> (2020) classification includes IPF but not IMF as a tumor in the category of benign fibroblastic and myofibroblastic tumors.<sup id="cite_ref-pmid33179614_4-1" class="reference"><a href="#cite_note-pmid33179614-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Treatment">Treatment</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Infantile_digital_fibromatosis&action=edit&section=4" title="Edit section: Treatment"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Infantile digital fibroma lesions were once thought to be potentially malignant and therefore treated with surgical excision and even digital amputations.<sup id="cite_ref-pmid27684985_8-3" class="reference"><a href="#cite_note-pmid27684985-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Currently, these tumors are known to be benign,<sup id="cite_ref-pmid33179614_4-2" class="reference"><a href="#cite_note-pmid33179614-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> may spontaneously regress, and often recur after surgical removal.<sup id="cite_ref-pmid27684985_8-4" class="reference"><a href="#cite_note-pmid27684985-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Consequently, IDF lesions are usually treated by a <a href="/wiki/Watchful_waiting" title="Watchful waiting">watchful waiting</a> observation approach with surgical resections limited to cases with functional impairment,<sup id="cite_ref-pmid33565473_3-6" class="reference"><a href="#cite_note-pmid33565473-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> significant symptoms, or progressive, long-term growth.<sup id="cite_ref-pmid29780440_7-4" class="reference"><a href="#cite_note-pmid29780440-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Alternate or supplemental treatments used to treat IDF include injection of the <a href="/wiki/Glucocorticoid" title="Glucocorticoid">glucocorticoid</a>, <a href="/wiki/Triamcinolone" title="Triamcinolone">triamcinolone</a>, or the <a href="/wiki/Chemotherapy" title="Chemotherapy">chemotherapy</a> drug, <a href="/wiki/5-fluorouracil" class="mw-redirect" title="5-fluorouracil">5-fluorouracil</a>, directly into the lesions.<sup id="cite_ref-pmid33565473_3-7" class="reference"><a href="#cite_note-pmid33565473-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Since these injection treatments have not been evaluated in large studies to date, surgical resection is the most accepted treatment of highly symptomatic or progressively enlarging IDF lesions.<sup id="cite_ref-pmid29780440_7-5" class="reference"><a href="#cite_note-pmid29780440-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Overall, the prognosis for IDF is excellent.<sup id="cite_ref-pmid33565473_3-8" class="reference"><a href="#cite_note-pmid33565473-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Infantile_digital_fibromatosis&action=edit&section=5" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Aggressive_infantile_fibromatosis" class="mw-redirect" title="Aggressive infantile fibromatosis">Infantile fibromatosis</a></li> <li><a href="/wiki/Skin_lesion" class="mw-redirect" title="Skin lesion">Skin lesion</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Infantile_digital_fibromatosis&action=edit&section=6" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-Fitz2-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-Fitz2_1-0">^</a></b></span> <span class="reference-text">Freedberg, et al. (2003). <i>Fitzpatrick's Dermatology in General Medicine</i>. (6th ed.). Page 989. McGraw-Hill. <style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/0-07-138076-0" title="Special:BookSources/0-07-138076-0">0-07-138076-0</a>.</span> </li> <li id="cite_note-pmid18830128-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid18830128_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid18830128_2-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLaskinMiettinenFetsch2009" class="citation journal cs1">Laskin WB, Miettinen M, Fetsch JF (January 2009). "Infantile digital fibroma/fibromatosis: a clinicopathologic and immunohistochemical study of 69 tumors from 57 patients with long-term follow-up". <i>The American Journal of Surgical Pathology</i>. <b>33</b> (1): 1–13. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2FPAS.0b013e3181788533">10.1097/PAS.0b013e3181788533</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18830128">18830128</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:30315278">30315278</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+American+Journal+of+Surgical+Pathology&rft.atitle=Infantile+digital+fibroma%2Ffibromatosis%3A+a+clinicopathologic+and+immunohistochemical+study+of+69+tumors+from+57+patients+with+long-term+follow-up&rft.volume=33&rft.issue=1&rft.pages=1-13&rft.date=2009-01&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A30315278%23id-name%3DS2CID&rft_id=info%3Apmid%2F18830128&rft_id=info%3Adoi%2F10.1097%2FPAS.0b013e3181788533&rft.aulast=Laskin&rft.aufirst=WB&rft.au=Miettinen%2C+M&rft.au=Fetsch%2C+JF&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInfantile+digital+fibromatosis" class="Z3988"></span></span> </li> <li id="cite_note-pmid33565473-3"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid33565473_3-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid33565473_3-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid33565473_3-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-pmid33565473_3-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-pmid33565473_3-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-pmid33565473_3-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-pmid33565473_3-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-pmid33565473_3-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-pmid33565473_3-8"><sup><i><b>i</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAgnihotriSathe2021" class="citation journal cs1">Agnihotri MA, Sathe PA (2021). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098864">"Inclusion body fibromatosis - A report of four cases and review of literature"</a>. <i>Journal of Postgraduate Medicine</i>. <b>67</b> (1): 24–26. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.4103%2Fjpgm.JPGM_774_20">10.4103/jpgm.JPGM_774_20</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8098864">8098864</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/33565473">33565473</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Postgraduate+Medicine&rft.atitle=Inclusion+body+fibromatosis+-+A+report+of+four+cases+and+review+of+literature&rft.volume=67&rft.issue=1&rft.pages=24-26&rft.date=2021&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC8098864%23id-name%3DPMC&rft_id=info%3Apmid%2F33565473&rft_id=info%3Adoi%2F10.4103%2Fjpgm.JPGM_774_20&rft.aulast=Agnihotri&rft.aufirst=MA&rft.au=Sathe%2C+PA&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC8098864&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInfantile+digital+fibromatosis" class="Z3988"></span></span> </li> <li id="cite_note-pmid33179614-4"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid33179614_4-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid33179614_4-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid33179614_4-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSbaragliaBellanDei_Tos2021" class="citation journal cs1">Sbaraglia M, Bellan E, Dei Tos AP (April 2021). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167394">"The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives"</a>. <i>Pathologica</i>. <b>113</b> (2): 70–84. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.32074%2F1591-951X-213">10.32074/1591-951X-213</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167394">8167394</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/33179614">33179614</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Pathologica&rft.atitle=The+2020+WHO+Classification+of+Soft+Tissue+Tumours%3A+news+and+perspectives&rft.volume=113&rft.issue=2&rft.pages=70-84&rft.date=2021-04&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC8167394%23id-name%3DPMC&rft_id=info%3Apmid%2F33179614&rft_id=info%3Adoi%2F10.32074%2F1591-951X-213&rft.aulast=Sbaraglia&rft.aufirst=M&rft.au=Bellan%2C+E&rft.au=Dei+Tos%2C+AP&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC8167394&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInfantile+digital+fibromatosis" class="Z3988"></span></span> </li> <li id="cite_note-pmid14322942-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid14322942_5-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFREYE1965" class="citation journal cs1">REYE RD (September 1965). "Recurring Digital Fibrous Tumors of Childhood". <i>Archives of Pathology</i>. <b>80</b>: 228–31. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14322942">14322942</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Archives+of+Pathology&rft.atitle=Recurring+Digital+Fibrous+Tumors+of+Childhood&rft.volume=80&rft.pages=228-31&rft.date=1965-09&rft_id=info%3Apmid%2F14322942&rft.aulast=REYE&rft.aufirst=RD&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInfantile+digital+fibromatosis" class="Z3988"></span></span> </li> <li id="cite_note-pmid34394250-6"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid34394250_6-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid34394250_6-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid34394250_6-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-pmid34394250_6-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-pmid34394250_6-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-pmid34394250_6-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-pmid34394250_6-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-pmid34394250_6-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-pmid34394250_6-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-pmid34394250_6-9"><sup><i><b>j</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFAdegokeAjaoAno-Edward2020" class="citation journal cs1">Adegoke OO, Ajao AE, Ano-Edward GH (December 2020). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351811">"Congenital infantile digital fibromatosis: a case report and review of the literature"</a>. <i>African Health Sciences</i>. <b>20</b> (4): 1865–1869. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.4314%2Fahs.v20i4.42">10.4314/ahs.v20i4.42</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351811">8351811</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/34394250">34394250</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=African+Health+Sciences&rft.atitle=Congenital+infantile+digital+fibromatosis%3A+a+case+report+and+review+of+the+literature&rft.volume=20&rft.issue=4&rft.pages=1865-1869&rft.date=2020-12&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC8351811%23id-name%3DPMC&rft_id=info%3Apmid%2F34394250&rft_id=info%3Adoi%2F10.4314%2Fahs.v20i4.42&rft.aulast=Adegoke&rft.aufirst=OO&rft.au=Ajao%2C+AE&rft.au=Ano-Edward%2C+GH&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC8351811&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInfantile+digital+fibromatosis" class="Z3988"></span></span> </li> <li id="cite_note-pmid29780440-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid29780440_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid29780440_7-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid29780440_7-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-pmid29780440_7-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-pmid29780440_7-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-pmid29780440_7-5"><sup><i><b>f</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFEypperLeeTarasenWeinberg2018" class="citation journal cs1">Eypper EH, Lee JC, Tarasen AJ, Weinberg MH, Adetayo OA (2018). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950536">"An Algorithmic Approach to the Management of Infantile Digital Fibromatosis: Review of Literature and a Case Report"</a>. <i>ePlasty</i>. <b>18</b>: e19. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5950536">5950536</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/29780440">29780440</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=ePlasty&rft.atitle=An+Algorithmic+Approach+to+the+Management+of+Infantile+Digital+Fibromatosis%3A+Review+of+Literature+and+a+Case+Report&rft.volume=18&rft.pages=e19&rft.date=2018&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5950536%23id-name%3DPMC&rft_id=info%3Apmid%2F29780440&rft.aulast=Eypper&rft.aufirst=EH&rft.au=Lee%2C+JC&rft.au=Tarasen%2C+AJ&rft.au=Weinberg%2C+MH&rft.au=Adetayo%2C+OA&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5950536&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInfantile+digital+fibromatosis" class="Z3988"></span></span> </li> <li id="cite_note-pmid27684985-8"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid27684985_8-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid27684985_8-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid27684985_8-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-pmid27684985_8-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-pmid27684985_8-4"><sup><i><b>e</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMarksEwart2016" class="citation journal cs1">Marks E, Ewart M (October 2016). <a rel="nofollow" class="external text" href="https://doi.org/10.5858%2Farpa.2015-0492-RS">"Infantile Digital Fibroma: A Rare Fibromatosis"</a>. <i>Archives of Pathology & Laboratory Medicine</i>. <b>140</b> (10): 1153–6. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.5858%2Farpa.2015-0492-RS">10.5858/arpa.2015-0492-RS</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27684985">27684985</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Archives+of+Pathology+%26+Laboratory+Medicine&rft.atitle=Infantile+Digital+Fibroma%3A+A+Rare+Fibromatosis&rft.volume=140&rft.issue=10&rft.pages=1153-6&rft.date=2016-10&rft_id=info%3Adoi%2F10.5858%2Farpa.2015-0492-RS&rft_id=info%3Apmid%2F27684985&rft.aulast=Marks&rft.aufirst=E&rft.au=Ewart%2C+M&rft_id=https%3A%2F%2Fdoi.org%2F10.5858%252Farpa.2015-0492-RS&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInfantile+digital+fibromatosis" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span 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fibromatosis</a></li> <li>Familial myxovascular fibromas</li> <li><a href="/wiki/Fibroma_of_tendon_sheath" title="Fibroma of tendon sheath">Fibroma of tendon sheath</a></li> <li><a href="/wiki/Fibromatosis_colli" title="Fibromatosis colli">Fibromatosis colli</a></li> <li><a class="mw-selflink selflink">Infantile digital fibromatosis</a></li> <li><a href="/wiki/Juvenile_hyaline_fibromatosis" title="Juvenile hyaline fibromatosis">Juvenile hyaline fibromatosis</a></li> <li><a href="/wiki/Plantar_fibromatosis" title="Plantar fibromatosis">Plantar fibromatosis</a></li> <li><a href="/wiki/Pleomorphic_fibroma" title="Pleomorphic fibroma">Pleomorphic fibroma</a></li> <li><a href="/wiki/Oral_submucous_fibrosis" title="Oral submucous fibrosis">Oral submucous fibrosis</a></li> <li><a href="/wiki/Pachydermodactyly" title="Pachydermodactyly">Pachydermodactyly</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Histiocytoma" title="Histiocytoma">Histiocytoma</a>/<a href="/wiki/Histiocytic_sarcoma" title="Histiocytic sarcoma">histiocytic sarcoma</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Benign_fibrous_histiocytoma" class="mw-redirect" title="Benign fibrous histiocytoma">Benign fibrous histiocytoma</a></li> <li><a href="/wiki/Pleomorphic_undifferentiated_sarcoma" class="mw-redirect" title="Pleomorphic undifferentiated sarcoma">Malignant fibrous histiocytoma</a></li> <li><a href="/wiki/Atypical_fibroxanthoma" title="Atypical fibroxanthoma">Atypical fibroxanthoma</a></li> <li><a href="/wiki/Solitary_fibrous_tumor" title="Solitary fibrous tumor">Solitary fibrous tumor</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Myxoma" title="Myxoma">Myxomatous</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Myxoma" title="Myxoma">Myxoma</a>/<a href="/wiki/Myxosarcoma" title="Myxosarcoma">myxosarcoma</a> <ul><li><a href="/wiki/Cutaneous_myxoma" title="Cutaneous myxoma">Cutaneous myxoma</a></li> <li><a href="/wiki/Superficial_acral_fibromyxoma" title="Superficial acral fibromyxoma">Superficial acral fibromyxoma</a></li></ul></li> <li><a href="/wiki/Aggressive_angiomyxoma" title="Aggressive angiomyxoma">Angiomyxoma</a></li> <li><a href="/wiki/Ossifying_fibromyxoid_tumour" title="Ossifying fibromyxoid tumour">Ossifying fibromyxoid tumour</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fibroepithelial_neoplasms" class="mw-redirect" title="Fibroepithelial neoplasms">Fibroepithelial</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Brenner_tumour" title="Brenner tumour">Brenner tumour</a></li> <li><a href="/wiki/Fibroadenoma" title="Fibroadenoma">Fibroadenoma</a></li> <li><a href="/wiki/Phyllodes_tumor" title="Phyllodes tumor">Phyllodes tumor</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Synovial_joint" title="Synovial joint">Synovial</a>-like</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Synovial_sarcoma" title="Synovial sarcoma">Synovial sarcoma</a></li> <li><a href="/wiki/Clear-cell_sarcoma" class="mw-redirect" title="Clear-cell sarcoma">Clear-cell sarcoma</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Adipose_tissue_neoplasm" title="Adipose tissue neoplasm">Lipomatous</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lipoma" title="Lipoma">Lipoma</a>/<a href="/wiki/Liposarcoma" title="Liposarcoma">liposarcoma</a> <ul><li><a href="/wiki/Myelolipoma" title="Myelolipoma">Myelolipoma</a></li> <li><a href="/wiki/Myxoid_liposarcoma" title="Myxoid liposarcoma">Myxoid liposarcoma</a></li></ul></li> <li><a href="/wiki/Perivascular_epithelioid_cell_tumour" title="Perivascular epithelioid cell tumour">PEComa</a> <ul><li><a href="/wiki/Angiomyolipoma" title="Angiomyolipoma">Angiomyolipoma</a></li></ul></li></ul> <ul><li><a href="/wiki/Chondroid_lipoma" title="Chondroid lipoma">Chondroid lipoma</a></li> <li><a href="/wiki/Intradermal_spindle_cell_lipoma" class="mw-redirect" title="Intradermal spindle cell lipoma">Intradermal spindle cell lipoma</a></li> <li><a href="/wiki/Pleomorphic_lipoma" title="Pleomorphic lipoma">Pleomorphic lipoma</a></li> <li><a href="/wiki/Lipoblastomatosis" title="Lipoblastomatosis">Lipoblastomatosis</a></li> <li><a href="/wiki/Spindle_cell_lipoma" title="Spindle cell lipoma">Spindle cell lipoma</a></li> <li><a href="/wiki/Hibernoma" title="Hibernoma">Hibernoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Muscle_tissue_neoplasm" class="mw-redirect" title="Muscle tissue neoplasm">Myomatous</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold">General</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Myoma" title="Myoma">Myoma</a>/<a href="/wiki/Myosarcoma" title="Myosarcoma">myosarcoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><a href="/wiki/Smooth_muscle_tissue" class="mw-redirect" title="Smooth muscle tissue">Smooth muscle</a></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Leiomyoma" title="Leiomyoma">Leiomyoma</a>/<a href="/wiki/Leiomyosarcoma" title="Leiomyosarcoma">leiomyosarcoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><a href="/wiki/Skeletal_muscle" title="Skeletal muscle">Skeletal muscle</a></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Rhabdomyoma" title="Rhabdomyoma">Rhabdomyoma</a>/<a href="/wiki/Rhabdomyosarcoma" title="Rhabdomyosarcoma">rhabdomyosarcoma</a>: <a href="/wiki/Embryonal_rhabdomyosarcoma" title="Embryonal rhabdomyosarcoma">Embryonal rhabdomyosarcoma</a> <ul><li><a href="/wiki/Sarcoma_botryoides" title="Sarcoma botryoides">Sarcoma botryoides</a></li></ul></li> <li><a href="/wiki/Alveolar_rhabdomyosarcoma" title="Alveolar rhabdomyosarcoma">Alveolar rhabdomyosarcoma</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Leiomyoma" title="Leiomyoma">Leiomyoma</a> <ul><li><a href="/wiki/Cutaneous_leiomyoma" title="Cutaneous leiomyoma">Cutaneous</a></li></ul></li> <li><a href="/wiki/Angioleiomyoma" title="Angioleiomyoma">Angioleiomyoma</a></li> <li><a href="/wiki/Angiolipoleiomyoma" title="Angiolipoleiomyoma">Angiolipoleiomyoma</a></li> <li><a href="/wiki/Genital_leiomyoma" title="Genital leiomyoma">Genital leiomyoma</a></li> <li><a href="/wiki/Leiomyosarcoma" title="Leiomyosarcoma">Leiomyosarcoma</a></li> <li><a href="/wiki/Hereditary_leiomyomatosis_and_renal_cell_cancer_syndrome" title="Hereditary leiomyomatosis and renal cell cancer syndrome">Multiple cutaneous and uterine leiomyomatosis syndrome</a></li> <li><a href="/wiki/Multiple_cutaneous_leiomyoma" class="mw-redirect" title="Multiple cutaneous leiomyoma">Multiple cutaneous leiomyoma</a></li> <li><a href="/wiki/Neural_fibrolipoma" title="Neural fibrolipoma">Neural fibrolipoma</a></li> <li><a href="/wiki/Solitary_cutaneous_leiomyoma" class="mw-redirect" title="Solitary cutaneous leiomyoma">Solitary cutaneous leiomyoma</a></li> <li><a href="/wiki/Smooth_muscle_tumor_of_uncertain_malignant_potential" title="Smooth muscle tumor of uncertain malignant potential">STUMP</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Complex_and_mixed_tumor" class="mw-redirect" title="Complex and mixed tumor">Complex mixed and stromal</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Adenomyoma" title="Adenomyoma">Adenomyoma</a></li> <li><a href="/wiki/Pleomorphic_adenoma" title="Pleomorphic adenoma">Pleomorphic adenoma</a></li> <li><a href="/wiki/Mixed_M%C3%BCllerian_tumor" title="Mixed Müllerian tumor">Mixed Müllerian tumor</a></li> <li><a href="/wiki/Mesoblastic_nephroma" title="Mesoblastic nephroma">Mesoblastic nephroma</a></li> <li><a href="/wiki/Wilms%27_tumor" title="Wilms' tumor">Wilms' tumor</a></li> <li><a href="/wiki/Malignant_rhabdoid_tumour" title="Malignant rhabdoid tumour">Malignant rhabdoid tumour</a></li> <li><a href="/wiki/Clear-cell_sarcoma_of_the_kidney" title="Clear-cell sarcoma of the kidney">Clear-cell sarcoma of the kidney</a></li> <li><a href="/wiki/Hepatoblastoma" title="Hepatoblastoma">Hepatoblastoma</a></li> <li><a href="/wiki/Pancreatoblastoma" title="Pancreatoblastoma">Pancreatoblastoma</a></li> <li><a href="/wiki/Carcinosarcoma" title="Carcinosarcoma">Carcinosarcoma</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Mesothelium" title="Mesothelium">Mesothelial</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mesothelioma" title="Mesothelioma">Mesothelioma</a></li> <li><a href="/wiki/Adenomatoid_tumor" title="Adenomatoid tumor">Adenomatoid tumor</a></li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Infantile_digital_fibromatosis&oldid=1241901435">https://en.wikipedia.org/w/index.php?title=Infantile_digital_fibromatosis&oldid=1241901435</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" 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