Proven miniaturization technology to bolster high-throughput protein biomarker discovery

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cell_16509743671752-padding dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-2 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1650974367007" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="gated-banner background image" style="background-image: url('https://www.sptlabtech.com/hubfs/SPT%20Labtech%20Website/06%20-%20Products/02%20-%20dragonfly/Re-uploads/dragonfly-product-category---testimonials-dfdiscovery-3.jpg')"> <div class="overlay" id="gated_landing_banner"> <div class="grey-overlay"> <div class="container"> <div class="flex-container"> <div class="center-height include-download-image"> <div class="content-box"> <h1>Proven miniaturization technology to bolster high-throughput protein biomarker discovery</h1> <div id="hs_cos_wrapper_widget_1650974367007_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_inline_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="inline_rich_text" data-hs-cos-field="text.supporting_text"><p><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><span>Explore new heights in high-throughput protein biomarker discovery with our powerful automated low-volume liquid handling technology. Harmoniously integrated with the expansive </span><span>Olink</span><span> Explore platform, our </span><span>instruments</span><span> enable swift, precise, and </span><span>accurate</span><span> execution of large-scale proteomic studies, spanning all crucial biological pathways.</span></span></p></div> </div> <div class="image-box"> <img src="https://www.sptlabtech.com/hubfs/dynamic-duo-banner-v4%20(1).png" alt="dynamic-duo-banner-v4 (1)"> </div> </div> </div> </div> </div> </div> </div> </div></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-3 main_area-row-1-padding main_area-row-1-max-width-section-centering dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-4 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1658500993325" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1658500993325_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><p><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><span>Our ‘</span></span><a href="https://www.sptlabtech.com/dynamic-duo-for-genomics-miniaturization" target="_blank" rel="noreferrer noopener"><span data-contrast="none" xml:lang="EN-GB" lang="EN-GB"><span data-ccp-charstyle="Hyperlink">dynamic duo</span></span></a><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><span>’ combines </span><span>the</span><span> </span><span>highly </span><span>accurate</span><span> positive</span><span>-</span><span>displacement pipetting</span><span> of </span></span><a href="https://www.sptlabtech.com/products/mosquito/mosquito-lv-genomics" target="_blank" rel="noreferrer noopener"><span data-contrast="none" xml:lang="EN-GB" lang="EN-GB"><span data-ccp-charstyle="Hyperlink">mosquito</span></span></a><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><sup><span>®</span></sup><span> </span><span>and </span><span>the </span><span>robust and reliable non-contact </span><span>nanoliter</span><span>-to-</span><span>milliliter</span><span> dispensing</span><span> of </span></span><a href="https://www.sptlabtech.com/products/dragonfly/dragonfly-discovery" target="_blank" rel="noreferrer noopener"><span data-contrast="none" xml:lang="EN-GB" lang="EN-GB"><span data-ccp-charstyle="Hyperlink">dragonfly<sup>®</sup> discovery</span></span></a><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><span>. </span><span>This</span><span> </span><span>proven</span><span> </span><span>partnership</span><span> has been </span></span><a href="https://www.sptlabtech.com/dynamic-duo-for-genomics-miniaturization#Over40NGSmethodsminiaturized" target="_blank" rel="noreferrer noopener"><span data-contrast="none" xml:lang="EN-GB" lang="EN-GB"><span data-ccp-charstyle="Hyperlink">widely validated </span><span data-ccp-charstyle="Hyperlink">across NGS methods</span></span></a><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><span>, enabling genomics researchers to </span><span>benefit</span><span> from significant cost savings by </span><span>drastically scal</span><span>ing</span><span> down reaction volumes</span><span> and extending the use of precious reagents and samples. Leveraging this technology with </span><a href="https://olink.com/products-services/explore/" rel="noopener" target="_blank"><span>Olink</span><span> Explore platform</span></a><span> </span><span>enables laborat</span><span>ories working</span><span> across the </span><span>life sciences</span><span> to uncover new biological insights</span><span> from minute amounts of sample.</span></span></p></span></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-5 main_area-row-2-max-width-section-centering main_area-row-2-padding dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-6 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1696949020261" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-header" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <span id="hs_cos_wrapper_widget_1696949020261_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_header" style="" data-hs-cos-general-type="widget" data-hs-cos-type="header"><h2>Why choose our dynamic duo?</h2></span></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-7 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-8 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1696949181364" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <div class="icon-text-block" id="icon-text-block"> <div class="container bullet-list-points"> <div class="icon-block"> <div class="row"> <div class="col-lg-4 col-md-6"> <div class="icon-text-box text-center"> <span class="icon"> <img src="https://www.sptlabtech.com/hubfs/SPT%20Labtech%20Website/00%20-%20Reusable%20Assets/icons/Re-uploads/precise-icon-1.png" alt="Unrivalled precision and accuracy even at ultra-low volumes" loading="lazy" style="max-width: 100%; height: auto;"> </span> <h6>Unrivalled precision and accuracy even at ultra-low volumes</h6> <p><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><span>Work confidently without</span><span> fear</span><span> of</span><span> harmful pipetting errors</span><span>, critical for success in </span><span>highly sensitive</span><span> quantitative assays </span><span>such as </span><span>Olink’s</span><span> proximity extension assay (PEA).</span></span></p> </div> </div> <div class="col-lg-4 col-md-6"> <div class="icon-text-box text-center"> <span class="icon"> <img src="https://www.sptlabtech.com/hubfs/SPT%20Labtech%20Website/00%20-%20Reusable%20Assets/icons/resources-icon-app-note.png" alt="Reliable and seamless operation across different experiments" loading="lazy" style="max-width: 100%; height: auto;"> </span> <h6>Reliable and seamless operation across different experiments</h6> <p><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><span>Eliminate</span><span> technical variability as a single low-cost mosquito spool </span><span>provides</span><span> enough disposable tips for multiple runs.</span></span></p> </div> </div> <div class="col-lg-4 col-md-6"> <div class="icon-text-box text-center"> <span class="icon"> <img src="https://www.sptlabtech.com/hubfs/SPT%20Labtech%20Website/00%20-%20Reusable%20Assets/icons/Re-uploads/resources-icon-case-study.png" alt="Proven solutions with a global footprint " loading="lazy" style="max-width: 100%; height: auto;"> </span> <h6>Proven solutions with a global footprint </h6> <p><span>Thousands of researchers around the world </span><span>are</span><span> already </span><span>leveraging</span><span> our dynamic duo to drive efficiency</span><span> in their liquid handling workflows</span><span>, with over 80 deployed for </span><span>Olink</span><span> Explore alone.</span></p> </div> </div> <div class="col-lg-4 col-md-6"> <div class="icon-text-box text-center"> <span class="icon"> <img src="https://www.sptlabtech.com/hubfs/SPT%20Labtech%20Website/00%20-%20Reusable%20Assets/icons/Re-uploads/graph-icon.png" alt="The chosen technology for service providers" loading="lazy" style="max-width: 100%; height: auto;"> </span> <h6>The chosen technology for service providers</h6> <p><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><span>Out of the 37 global </span><span>Olink</span><span> Explore service providers, 36 are equipped with mosquito and dragonfly discovery.</span></span></p> </div> </div> <div class="col-lg-4 col-md-6"> <div class="icon-text-box text-center"> <span class="icon"> <img src="https://www.sptlabtech.com/hubfs/SPT%20Labtech%20Website/00%20-%20Reusable%20Assets/icons/resources-icon-webinar-gre.png" alt="Webinar: Supercharge your Olink workflow with the right liquid handling tools" loading="lazy" style="max-width: 100%; height: auto;"> </span> <h6>Webinar: Supercharge your Olink workflow with the right liquid handling tools</h6> <p><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><span>Hear first-hand the </span><span>value of positive displacement technologies for effective multi-omics assay miniaturization</span><span>.</span></span></p> <p><a href="/resources/webinar-supercharge-your-olink-workflow-with-the-right-liquid-handling-tools" rel="noopener"><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><span>Watch webinar</span></span></a></p> </div> </div> <div class="col-lg-4 col-md-6"> <div class="icon-text-box text-center"> <span class="icon"> <img src="https://www.sptlabtech.com/hubfs/SPT%20Labtech%20Website/00%20-%20Reusable%20Assets/icons/Re-uploads/doc-with-magnify-icon-1.png" alt="Paper: Introducing Olink Explore for High-throughput Proteome-wide Analysis" loading="lazy" style="max-width: 100%; height: auto;"> </span> <h6>Paper: Introducing Olink Explore for High-throughput Proteome-wide Analysis</h6> <p><span>Explore the </span><span>advanced</span><span> tool for p</span><span>rotein discover</span><span>y and quantification, </span><span>performed using SPT Labtech’s innovative miniaturization technology.</span></p> <p><a href="https://www.mcponline.org/article/S1535-9476(21)00140-7/fulltext" rel="noopener" target="_blank"><span>Learn more</span></a></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-9 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell cell_1718272502434-margin dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-10 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1718272246208" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><div class="o-section o-section--testimonial"> <div class="container"> <div class="row"> <div class="col-md-12"> <div class="c-testimonial"> <h2>Hear from our dynamic duo users</h2> <div id="c-mosquitoSlider"> <div class="c-testimonial__inner"> <div class="c-testimonial__image"> <img src="https://www.sptlabtech.com/hubfs/FIRMOL_LOGO_Main.png" alt="FIRMOL_LOGO_Main" loading="lazy" style="max-width: 100%; height: auto;"> </div> <div class="c-testimonial__text"> <div class="c-testimonial__quote"><p>"SPT Labtech enabled <a href="https://firalismolecularprecision.com/" rel="noopener">Firalis Molecular Precision</a> to handle low-volume liquids with high reproducibility in the Olink Explore Process using the mosquito and dragonfly instruments. It allowed our experts to fully automate the biomarker screening process and provide better and higher quality results to our clients."</p></div> <p class="c-testimonial__author">— Aurélien Virciglio, Proteomics Lab Head, Firalis Molecular Precision</p> </div> </div> </div> </div> </div> </div> </div> </div></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-11 dnd-section main_area-row-5-padding main_area-row-5-max-width-section-centering"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-12 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1651579440566" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module widget-type-rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"><span id="hs_cos_wrapper_widget_1651579440566_" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_rich_text" style="" data-hs-cos-general-type="widget" data-hs-cos-type="rich_text"><a id="Over40NGSmethodsminiaturized" data-hs-anchor="true"></a> <h3><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><span>Success highlights</span></span></h3> <p><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB">There have been over 90 publications showcasing our dynamic duo for the Olink Explore platform since 2021. We’ve highlighted a few examples below:</span> </span></p> <div data-hs-responsive-table="true" style="overflow-x: auto; max-width: 100%; width: 100%; margin: 0px auto;"> <table style="width: 100%; border-collapse: collapse; table-layout: fixed; border: 1px solid #99acc2;"> <tbody> <tr style="height: 32.6667px;"> <td style="width: 30.7151%; padding: 4px 4px 4px 44px; height: 32.6667px; background-color: #d40f7d; border: 1px solid #ffffff;"><span style="color: #ffffff;"><strong>Publication</strong></span></td> <td style="width: 69.2781%; padding: 4px 4px 4px 44px; height: 32.6667px; background-color: #d40f7d; border: 1px solid #ffffff;"><span style="color: #ffffff;"><strong>Description</strong></span></td> </tr> <tr style="height: 150px;"> <td style="width: 30.7151%; padding: 4px; height: 150px; background-color: #f4f7f9; border: 1px solid #ffffff;"> <p style="padding-left: 40px; font-size: 14px;"><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"><span style="font-weight: normal;">Sun <span style="font-style: italic;">et al</span>. (2023)</span><span style="font-weight: bold;"> Plasma proteomic associations with genetics and health in the UK Biobank. </span><span style="font-weight: normal;">Nature, </span><a href="https://www.nature.com/articles/s41586-023-06592-6" rel="noopener" target="_blank" style="font-weight: normal;">DOI: 10.1038/s41586-023-06592-600</a></span></p> </td> <td style="width: 69.2781%; padding: 4px; height: 150px; background-color: #f4f7f9; border: 1px solid #ffffff;"> <p style="font-size: 14px; padding-left: 40px;"><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}">The largest proteomic study conducted to date (over 54,000 UK Biobank participants) by the Pharma Proteomics Project reveals biological insights into proteomic disease signatures, and prediction models for demographic and health indicators. The results not only validated several established proteomic associations, but also uncovered 4,287 pQTLs (protein quantitative trait loci), 81% of which are novel genetic associations with protein levels that have not been previously reported.</span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"></span><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"></span></p> </td> </tr> <tr style="height: 150px;"> <td style="width: 30.7151%; padding: 4px; height: 150px; background-color: #f4f7f9; border: 1px solid #ffffff;"> <p style="padding-left: 40px; font-size: 14px;"><span style="font-weight: normal;">Dhindsa <span style="font-style: italic;">et al</span>. (2023)</span><span style="font-weight: bold;"> Rare variant associations with plasma protein levels in the UK Biobank. </span><span style="font-weight: normal;">Nature, </span><a href="https://www.nature.com/articles/s41586-023-06547-x" rel="noopener" target="_blank" style="font-weight: normal;">DOI: 10.1038/s41586-023-06547-x</a></p> </td> <td style="width: 69.2781%; padding: 4px; height: 150px; background-color: #f4f7f9; border: 1px solid #ffffff;"> <p style="font-size: 14px; padding-left: 40px;"><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}">An extensive rare variant proteogenomics study by AstraZeneca Genomics Initiative included 2,923 plasma protein abundances measured in 49,736 UK Biobank human exomes. The paper highlights several examples of how this protein-coding pQTL atlas can address drug discovery and clinical pipeline challenges. It is anticipated that this resource will provide novel insights into protein regulatory networks, upstream trans regulators of target genes whose inhibition could increase target protein levels, target safety assessments and drug repositioning opportunities.</span></p> </td> </tr> <tr style="height: 150px;"> <td style="width: 30.7151%; padding: 4px; height: 150px; background-color: #f4f7f9; border: 1px solid #ffffff;"> <p style="padding-left: 40px; font-size: 14px;"><span style="font-weight: normal;">Álvez <span style="font-style: italic;">et al</span>. (2023)</span><span style="font-weight: bold;"> Next generation pan-cancer blood proteome profiling using proximity extension assay. </span><span style="font-weight: normal;">Nat Commun, </span><a href="https://www.nature.com/articles/s41467-023-39765-y" rel="noopener" target="_blank" style="font-weight: normal;">DOI: 10.1038/s41467-023-39765-y</a></p> </td> <td style="width: 69.2781%; padding: 4px; height: 150px; background-color: #f4f7f9; border: 1px solid #ffffff;"> <p style="font-size: 14px; padding-left: 40px;"><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}">The paper describes a strategy for cost-effective pan-cancer analysis of blood protein profiles with the goal to allow simultaneous identification of cancers using only a few microliters of blood. This approach combined with machine learning and traditional cancer screening procedures could facilitate the discovery of cancers early, and thus help clinicians to start treatment of cancer patients at earlier stages.</span></p> </td> </tr> <tr style="height: 20px;"> <td style="width: 30.7151%; padding: 4px; height: 20px; background-color: #f4f7f9; border: 1px solid #ffffff;"> <p style="padding-left: 40px; font-size: 14px;"><span style="font-weight: normal;">Sveinbjornsson <span style="font-style: italic;">et al</span>. (2022)</span><span style="font-weight: bold;"> Multiomics study of nonalcoholic fatty liver disease. </span><span style="font-weight: normal;">Nat Genet, </span><a href="https://www.nature.com/articles/s41588-022-01199-5" rel="noopener" target="_blank" style="font-weight: normal;">DOI: 10.1038/s41588-022-01199-5</a></p> </td> <td style="width: 69.2781%; padding: 4px; height: 20px; background-color: #f4f7f9; border: 1px solid #ffffff;"> <p style="font-size: 14px; padding-left: 40px;"><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}">Integration of genome-wide association study of non-alcoholic fatty liver, cirrhosis and hepatocellular carcinoma with gene expression and proteomic data identifies new sequence variants, putative casual genes and multiple proteins involved in liver disease pathogenesis, underscoring them as potential drug targets. The study highlights the potential of measurement of plasma proteins to serve as a non-invasive tool for use in the diagnosis and monitoring of disease.</span></p> </td> </tr> <tr style="height: 150px;"> <td style="width: 30.7151%; padding: 4px; height: 150px; background-color: #f4f7f9; border: 1px solid #ffffff;"> <p style="padding-left: 40px; font-size: 14px;"><span style="font-weight: normal;">Zannad <span style="font-style: italic;">et al.</span> (2022)</span><span style="font-weight: bold;"> Effect of a <span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}">sodium-glucose cotransporter-2 (SGLT2) inhibitor</span> on circulating proteomics in heart failure: mechanistic insights into the EMPEROR programme. </span><span style="font-weight: normal;">European Heart Journal, </span><a href="https://academic.oup.com/eurheartj/article/43/48/4991/6676779" rel="noopener" target="_blank" style="font-weight: normal;">DOI: 10.1093/eurheartj/ehac495</a></p> </td> <td style="width: 69.2781%; padding: 4px; height: 150px; background-color: #f4f7f9; border: 1px solid #ffffff;"> <p style="padding-left: 40px; font-size: 14px;"><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}">The EMPEROR studies (Phase 3, randomized, double-blind trials) were conducted in patients with and without diabetes, and investigated effect of a sodium-glucose cotransporter-2 (SGLT2) inhibitor on the circulating levels of intracellular proteins in patients with chronic heart failure. The results of this large-scale proteomics study show that the effects of SGLT2 inhibitors are likely related to actions on the heart and kidney to promote autophagic flux, nutrient deprivation signalling and transmembrane sodium transport.</span></p> </td> </tr> <tr style="height: 150px;"> <td style="width: 30.7151%; padding: 4px; background-color: #f4f7f9; border: 1px solid #ffffff; height: 150px;"> <p style="padding-left: 40px; font-size: 14px;"><span style="font-weight: normal;">Filbin <span style="font-style: italic;">et al.</span> (2021)</span><span style="font-weight: bold;"> Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions. </span><span style="font-weight: normal;">Cell Reports Medicine, </span><a href="https://pubmed.ncbi.nlm.nih.gov/33969320/" rel="noopener" target="_blank" style="font-weight: normal;">DOI: 10.1016/j.xcrm.2021.100287</a><span style="font-weight: bold;"></span></p> </td> <td style="width: 69.2781%; padding: 4px; background-color: #f4f7f9; border: 1px solid #ffffff; height: 150px;"> <p style="padding-left: 40px; font-size: 14px;"><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}"><span data-ccp-props="{"201341983":0,"335559739":160,"335559740":259}">By leveraging protein signatures with scRNA-seq datasets from PBMCs of COVID-19 patients and from healthy tissues, researchers identified over 257 proteins independently associated with COVID-19 severity at day zero and over 700 proteins at day three and seven. “This work lays the foundation for understanding how the plasma proteome can be leveraged to gain insights into underlying disease pathways and potential therapeutic targets, and to develop diagnostics that can be used to stratify high-risk patients as candidates for tailored therapies and earlier interventions.”</span></span></p> </td> </tr> </tbody> </table> </div> <p> </p></span></div> </div> </div> </div> </div> </div> </div> <div class="row-fluid-wrapper row-depth-1 row-number-13 dnd-section"> <div class="row-fluid "> <div class="span12 widget-span widget-type-cell dnd-column" style="" data-widget-type="cell" data-x="0" data-w="12"> <div class="row-fluid-wrapper row-depth-1 row-number-14 dnd-row"> <div class="row-fluid "> <div class="span12 widget-span widget-type-custom_widget dnd-module" style="" data-widget-type="custom_widget" data-x="0" data-w="12"> <div id="hs_cos_wrapper_widget_1660312938724" class="hs_cos_wrapper hs_cos_wrapper_widget hs_cos_wrapper_type_module" style="" data-hs-cos-general-type="widget" data-hs-cos-type="module"> <section id="benefits" class="o-section two-columns-image-text u-bg-white o-section--large false" style=" padding-bottom: 0; "> <div class="container"> <div class="row"> <div class="col-lg-6 col-md-12 images"> <img class="pic" src="https://www.sptlabtech.com/hubfs/SPT%20Labtech%20Website/07%20-%20About/02%20-%20Life%20at%20SPT%20Labtech/reliance-hero.jpg" alt="reliance-hero" loading="lazy" style="max-width: 100%; height: auto;"> </div> <div class="col-lg-6 col-md-12 content" style=""> <h3>Reach your goals with best-in-class service and support</h3> <p><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><span>When you invest in SPT Labtech solutions, you get access to </span><span>our</span><span> </span></span><a href="https://www.sptlabtech.com/reliance" target="_blank" rel="noreferrer noopener"><span data-contrast="none" xml:lang="EN-GB" lang="EN-GB"><span data-ccp-charstyle="Hyperlink">dedicated </span><span data-ccp-charstyle="Hyperlink">support team of Engineers and Application Scientists</span></span></a><span data-contrast="auto" xml:lang="EN-GB" lang="EN-GB"><span>. 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Proven miniaturization technology to bolster high-throughput protein biomarker discovery​ | SPT Labtech

Proven miniaturization technology to bolster high-throughput protein biomarker discovery | SPT Labtech