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class="mbox-text" style="width: auto;"><div class="mbox-text-span">This list is <a href="/wiki/Wikipedia:WikiProject_Lists#Incomplete_lists" title="Wikipedia:WikiProject Lists">incomplete</a>; you can help by <a class="external text" href="https://en.wikipedia.org/w/index.php?title=List_of_withdrawn_drugs&action=edit">adding missing items</a>. (July 2015)</div></td></tr></tbody></table> <a href="/wiki/Medication" title="Medication">Drugs</a> or medicines may be withdrawn from commercial markets because of risks to patients, but also because of commercial reasons (e.g. lack of demand and relatively high production costs). Where risks or harms is the reason for withdrawal, this will usually have been prompted by unexpected adverse effects that were not detected during Phase III <a href="/wiki/Clinical_trials" class="mw-redirect" title="Clinical trials">clinical trials</a>, i.e. they were only made apparent from <a href="/wiki/Postmarketing_surveillance" title="Postmarketing surveillance">postmarketing surveillance</a> data collected from the wider community over longer periods of time. This list is not limited to drugs that were ever approved by the FDA. Some of them (lumiracoxib, rimonabant, tolrestat, ximelagatran and ximelidine, for example) were approved to be marketed in Europe but had not yet been approved for marketing in the US, when side effects became clear and their developers pulled them from the market. Some drugs in this list (e.g. LSD) were never approved for marketing in the US or Europe. <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Significant_withdrawals">Significant withdrawals</h2>[<a href="/w/index.php?title=List_of_withdrawn_drugs&action=edit&section=1" title="Edit section: Significant withdrawals">edit</a>]</div> <table class="wikitable sortable"> <tbody><tr> <th>Drug name </th> <th>Withdrawn </th> <th>Country </th> <th class="unsortable">Remarks </th></tr> <tr> <td><a href="/wiki/Amphetamine" title="Amphetamine">Amphetamine</a> Mix (<a href="/wiki/Adderall" title="Adderall">Adderall XR</a>) </td> <td>2005 </td> <td>Canada </td> <td>Withdrawn over reports of increased risk of <a href="/wiki/Stroke" title="Stroke">stroke</a>, reinstated after increased risk not found.<a href="#cite_note-1">[1]</a> </td></tr> <tr> <td><a href="/wiki/Alatrofloxacin" title="Alatrofloxacin">Alatrofloxacin</a> </td> <td>2006 </td> <td>Worldwide </td> <td>Serious <a href="/wiki/Hepatotoxicity" title="Hepatotoxicity">hepatotoxicity</a> leading to liver transplant or death.<a href="#cite_note-Qureshi-2011-2">[2]</a> </td></tr> <tr> <td><a href="/wiki/Alclofenac" title="Alclofenac">Alclofenac</a> </td> <td>1979 </td> <td>UK </td> <td><a href="/wiki/Vasculitis" title="Vasculitis">Vasculitis</a><a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Alpidem" title="Alpidem">Alpidem</a> (Ananxyl) </td> <td>1995 </td> <td>Worldwide </td> <td>Not approved in the US, withdrawn in France in 1994<a href="#cite_note-4">[4]</a> and the rest of the market in 1995 because of rare but serious <a href="/wiki/Hepatotoxicity" title="Hepatotoxicity">hepatotoxicity</a>.<a href="#cite_note-Fung-2001-3">[3]</a><a href="#cite_note-5">[5]</a> </td></tr> <tr> <td><a href="/wiki/Alosetron" title="Alosetron">Alosetron</a> (Lotronex) </td> <td>2000 </td> <td>US </td> <td>Serious gastrointestinal adverse events; <a href="/wiki/Ischemic_colitis" title="Ischemic colitis">ischemic colitis</a>; severe <a href="/wiki/Constipation" title="Constipation">constipation</a>.<a href="#cite_note-Qureshi-2011-2">[2]</a> Reintroduced 2002 with restricted indication and new controls.<a href="#cite_note-6">[6]</a> </td></tr> <tr> <td><a href="/wiki/Alphaxolone" class="mw-redirect" title="Alphaxolone">Alphaxolone</a>/<a href="/wiki/Alphadolone" class="mw-redirect" title="Alphadolone">Alphadolone</a> (<a href="/wiki/Alfaxolone/alfadolone" title="Alfaxolone/alfadolone">Althesin</a>) </td> <td>1984 </td> <td>France, Germany, UK </td> <td><a href="/wiki/Anaphylaxis" title="Anaphylaxis">Anaphylaxis</a>, possibly due to carrier oil (<a href="/wiki/Kolliphor_EL" title="Kolliphor EL">Cremophor EL</a>).<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Amineptine" title="Amineptine">Amineptine</a> (Survector) </td> <td>1999 </td> <td>France, US </td> <td><a href="/wiki/Hepatotoxicity" title="Hepatotoxicity">Hepatotoxicity</a>, <a href="/wiki/Dermatological" class="mw-redirect" title="Dermatological">dermatological</a> side effects, and <a href="/wiki/Drug_abuse" class="mw-redirect" title="Drug abuse">abuse</a> potential.<a href="#cite_note-7">[7]</a> </td></tr> <tr> <td><a href="/wiki/Aminopyrine" class="mw-redirect" title="Aminopyrine">Aminopyrine</a> </td> <td>1999 </td> <td>France, Thailand </td> <td>Risk of <a href="/wiki/Agranulocytosis" title="Agranulocytosis">agranulocytosis</a> and severe acne.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Amobarbital" title="Amobarbital">Amobarbital</a> </td> <td>1980 </td> <td>Norway </td> <td>Risk of <a href="/wiki/Barbiturate_overdose" title="Barbiturate overdose">barbiturate toxicity</a>.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/w/index.php?title=Amoproxan&action=edit&redlink=1" class="new" title="Amoproxan (page does not exist)">Amoproxan</a> </td> <td>1970 </td> <td>France </td> <td>Dermatologic and ophthalmic toxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Anagestone_acetate" title="Anagestone acetate">Anagestone acetate</a> </td> <td>1969 </td> <td>Germany </td> <td>Animal carcinogenicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Antrafenine" title="Antrafenine">Antrafenine</a> </td> <td>1984 </td> <td>France </td> <td>Unspecific experimental toxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Aprotinin" title="Aprotinin">Aprotinin</a> (Trasylol) </td> <td>2008 </td> <td>US </td> <td>Increased risk of death.<a href="#cite_note-Qureshi-2011-2">[2]</a> </td></tr> <tr> <td><a href="/wiki/Ardeparin" title="Ardeparin">Ardeparin</a> (Normiflo) </td> <td>2001 </td> <td>US </td> <td>Withdrawn at request of <a href="/wiki/New_Drug_Application" title="New Drug Application">NDA</a> originator, "not for reason of safety or efficacy."<a href="#cite_note-8">[8]</a><a href="#cite_note-9">[9]</a> </td></tr> <tr> <td><a href="/wiki/Astemizole" title="Astemizole">Astemizole</a> (Hismanal) </td> <td>1999 </td> <td>US, Malaysia, Multiple Nonspecified Markets </td> <td>Fatal <a href="/wiki/Arrhythmia" title="Arrhythmia">arrhythmia</a><a href="#cite_note-Qureshi-2011-2">[2]</a><a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Azaribine" title="Azaribine">Azaribine</a> </td> <td>1976 </td> <td>US </td> <td><a href="/wiki/Thrombosis" title="Thrombosis">Thromboembolism</a>.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Bendazac" title="Bendazac">Bendazac</a> </td> <td>1993 </td> <td>Spain </td> <td>Hepatotoxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Benoxaprofen" title="Benoxaprofen">Benoxaprofen</a> (Oraflex, Opren) </td> <td>1982 </td> <td>Germany, Spain, UK, US </td> <td>Liver and kidney failure; gastrointestinal bleeding; ulcers.<a href="#cite_note-Qureshi-2011-2">[2]</a><a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/w/index.php?title=Benzarone&action=edit&redlink=1" class="new" title="Benzarone (page does not exist)">Benzarone</a> </td> <td>1992 </td> <td>Germany </td> <td>Hepatitis.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Benziodarone" title="Benziodarone">Benziodarone</a> </td> <td>1964 </td> <td>France, UK </td> <td>Jaundice.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/w/index.php?title=Beta-ethoxy-lacetanilanide&action=edit&redlink=1" class="new" title="Beta-ethoxy-lacetanilanide (page does not exist)">Beta-ethoxy-lacetanilanide</a> </td> <td>1986 </td> <td>Germany </td> <td>Renal toxicity, animal carcinogenicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Bezitramide" title="Bezitramide">Bezitramide</a> </td> <td>2004 </td> <td>Netherlands </td> <td>Risk of fatal overdose<a href="#cite_note-10">[10]</a> </td></tr> <tr> <td><a href="/wiki/Bithionol" title="Bithionol">Bithionol</a> </td> <td>1967 </td> <td>US </td> <td>Dermatologic toxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Brotizolam" title="Brotizolam">Brotizolam</a> </td> <td>1989 </td> <td>UK </td> <td>Animal carcinogenicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Bromfenac" title="Bromfenac">Bromfenac</a> </td> <td>1998 </td> <td>US </td> <td>Severe hepatitis and liver failure (requiring transplantation).<a href="#cite_note-Qureshi-2011-2">[2]</a> </td></tr> <tr> <td><a href="/wiki/Bucetin" title="Bucetin">Bucetin</a> </td> <td>1986 </td> <td>Germany </td> <td>Kidney damage<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Buformin" title="Buformin">Buformin</a> </td> <td>1978 </td> <td>Germany </td> <td>Metabolic toxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/w/index.php?title=Bunamiodyl&action=edit&redlink=1" class="new" title="Bunamiodyl (page does not exist)">Bunamiodyl</a> </td> <td>1963 </td> <td>Canada, UK, US </td> <td>Nephropathy.<a href="#cite_note-11">[11]</a> </td></tr> <tr> <td><a href="/wiki/Butamben" title="Butamben">Butamben</a> (Efocaine)(Butoforme) </td> <td>1964 </td> <td>US </td> <td>Dermatologic toxicity; psychiatric reactions.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Canrenone" title="Canrenone">Canrenone</a> </td> <td>1986 </td> <td>Germany </td> <td>Animal Carcinogenicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Cerivastatin" title="Cerivastatin">Cerivastatin</a> (Baycol, Lipobay) </td> <td>2001 </td> <td>US </td> <td>Risk of <a href="/wiki/Rhabdomyolysis" title="Rhabdomyolysis">rhabdomyolysis</a><a href="#cite_note-Qureshi-2011-2">[2]</a> </td></tr> <tr> <td><a href="/wiki/Chlormadinone" title="Chlormadinone">Chlormadinone</a> (Chlormenadione) </td> <td>1970 </td> <td>UK, US </td> <td>Animal Carcinogenicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Chlormezanone" title="Chlormezanone">Chlormezanone</a> (Trancopal) </td> <td>1996 </td> <td>European Union, US, South Africa, Japan </td> <td>Hepatotoxicity and <a href="/wiki/Stevens%E2%80%93Johnson_syndrome" title="Stevens–Johnson syndrome">Stevens–Johnson Syndrome</a><a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Chlorphentermine" title="Chlorphentermine">Chlorphentermine</a> </td> <td>1969 </td> <td>Germany </td> <td>Cardiovascular Toxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Cianidanol" class="mw-redirect" title="Cianidanol">Cianidanol</a> </td> <td>1985 </td> <td>France, Germany, Spain, Sweden </td> <td>Hemolytic Anemia.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Cinepazide" title="Cinepazide">Cinepazide</a> </td> <td>1988 </td> <td>Spain </td> <td>Agranulocytosis.<a href="#cite_note-WHO2005-12">[12]</a><a href="#cite_note-13">[13]</a> </td></tr> <tr> <td><a href="/wiki/Cisapride" title="Cisapride">Cisapride</a> (Propulsid) </td> <td>2000 </td> <td>US </td> <td>Risk of fatal <a href="/wiki/Cardiac_arrhythmias" class="mw-redirect" title="Cardiac arrhythmias">cardiac arrhythmias</a><a href="#cite_note-Qureshi-2011-2">[2]</a> </td></tr> <tr> <td><a href="/wiki/Clioquinol" title="Clioquinol">Clioquinol</a> </td> <td>1973 </td> <td>France, Germany, UK, US </td> <td>Neurotoxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Clobutinol" title="Clobutinol">Clobutinol</a> </td> <td>2007 </td> <td>Germany </td> <td>Ventricular arrhythmia, QT-prolongation.<a href="#cite_note-Schubert-Zsilavecz-14">[14]</a> </td></tr> <tr> <td><a href="/wiki/Cloforex" title="Cloforex">Cloforex</a> </td> <td>1969 </td> <td>Germany </td> <td>Cardiovascular toxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/w/index.php?title=Clomacron&action=edit&redlink=1" class="new" title="Clomacron (page does not exist)">Clomacron</a> </td> <td>1982 </td> <td>UK </td> <td>Hepatotoxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/w/index.php?title=Clometacin&action=edit&redlink=1" class="new" title="Clometacin (page does not exist)">Clometacin</a> </td> <td>1987 </td> <td>France </td> <td>Hepatotoxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Co-proxamol" class="mw-redirect" title="Co-proxamol">Co-proxamol</a> (Distalgesic) </td> <td>2004 </td> <td>UK </td> <td>Risk of overdose </td></tr> <tr> <td><a href="/wiki/Cyclobarbital" title="Cyclobarbital">Cyclobarbital</a> </td> <td>1980 </td> <td>Norway </td> <td>Risk of overdose<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Cyclofenil" title="Cyclofenil">Cyclofenil</a> </td> <td>1987 </td> <td>France </td> <td>Hepatotoxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Dantron" title="Dantron">Dantron</a> </td> <td>1963 </td> <td>Canada, UK, US </td> <td><a href="/wiki/Mutagenic" class="mw-redirect" title="Mutagenic">Mutagenic</a>.<a href="#cite_note-15">[15]</a> withdrawn from general use in UK but permitted in terminal patients </td></tr> <tr> <td><a href="/wiki/Dexfenfluramine" title="Dexfenfluramine">Dexfenfluramine</a> </td> <td>1997 </td> <td>European Union, UK, US </td> <td><a href="/wiki/Cardiotoxic" class="mw-redirect" title="Cardiotoxic">Cardiotoxic</a><a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Dextropropoxyphene" title="Dextropropoxyphene">Propoxyphene</a> (Darvocet/Darvon) </td> <td>2010 </td> <td>Worldwide </td> <td>Increased risk of heart attacks and stroke.<a href="#cite_note-16">[16]</a> </td></tr> <tr> <td><a href="/w/index.php?title=Diacetoxydiphenolisatin&action=edit&redlink=1" class="new" title="Diacetoxydiphenolisatin (page does not exist)">Diacetoxydiphenolisatin</a> </td> <td>1971 </td> <td>Australia </td> <td>Hepatotoxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Diethylstilbestrol" title="Diethylstilbestrol">Diethylstilbestrol</a> </td> <td>1970s </td> <td>US </td> <td>Carcinogen </td></tr> <tr> <td><a href="/wiki/Difemerine" title="Difemerine">Difemerine</a> </td> <td>1986 </td> <td>Germany </td> <td>Multi-Organ toxicities.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Dihydrostreptomycin" title="Dihydrostreptomycin">Dihydrostreptomycin</a> </td> <td>1970 </td> <td>US </td> <td>Neuropsychiatric reaction.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Dilevalol" class="mw-redirect" title="Dilevalol">Dilevalol</a> </td> <td>1990 </td> <td>UK </td> <td>Hepatotoxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Dimazole" title="Dimazole">Dimazole</a> (Diamthazole) </td> <td>1972 </td> <td>France, US </td> <td>Neuropsychiatric reaction.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Dimethylamylamine" class="mw-redirect" title="Dimethylamylamine">Dimethylamylamine</a> (DMAA) </td> <td>1983 </td> <td>US </td> <td>Voluntarily withdrawn from market by Lily.<a href="#cite_note-DODTox-17">[17]</a>: 12  Reintroduced as a <a href="/wiki/Dietary_supplement" title="Dietary supplement">dietary supplement</a> in 2006;<a href="#cite_note-DODTox-17">[17]</a>: 13  in 2013 the FDA started work to ban it due to cardiovascular problems<a href="#cite_note-18">[18]</a> </td></tr> <tr> <td><a href="/wiki/Dinoprostone" class="mw-redirect" title="Dinoprostone">Dinoprostone</a> </td> <td>1990 </td> <td>UK </td> <td>Uterine hypotonus, fetal distress.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Dipyrone" class="mw-redirect" title="Dipyrone">Dipyrone</a> (<a href="/wiki/Metamizole" title="Metamizole">Metamizole</a>) </td> <td>1975 </td> <td>UK, US, Others </td> <td>Agranulocytosis, anaphylactic reactions.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Dithiazanine_iodide" title="Dithiazanine iodide">Dithiazanine iodide</a> </td> <td>1964 </td> <td>France, US </td> <td>Cardiovascular and metabolic reaction.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Dofetilide" title="Dofetilide">Dofetilide</a> </td> <td>2004 </td> <td>Germany </td> <td>Drug interactions, prolonged QT.<a href="#cite_note-Schubert-Zsilavecz-14">[14]</a> </td></tr> <tr> <td><a href="/wiki/Drotrecogin_alfa" title="Drotrecogin alfa">Drotrecogin alfa</a> (Xigris) </td> <td>2011 </td> <td>Worldwide </td> <td>Lack of efficacy as shown by PROWESS-SHOCK study<a href="#cite_note-19">[19]</a><a href="#cite_note-20">[20]</a><a href="#cite_note-21">[21]</a> </td></tr> <tr> <td><a href="/wiki/Ebrotidine" title="Ebrotidine">Ebrotidine</a> </td> <td>1998 </td> <td>Spain </td> <td>Hepatotoxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Efalizumab" title="Efalizumab">Efalizumab</a> (Raptiva) </td> <td>2009 </td> <td>Germany </td> <td>Withdrawn because of increased risk of progressive multifocal leukoencephalopathy<a href="#cite_note-Schubert-Zsilavecz-14">[14]</a> </td></tr> <tr> <td><a href="/wiki/Encainide" title="Encainide">Encainide</a> </td> <td>1991 </td> <td>UK, US </td> <td>Ventricular arrhythmias.<a href="#cite_note-Qureshi-2011-2">[2]</a><a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Ethyl_carbamate" title="Ethyl carbamate">Ethyl carbamate</a> </td> <td>1963 </td> <td>Canada, UK, US </td> <td>Carcinogen.<a href="#cite_note-22">[22]</a> </td></tr> <tr> <td><a href="/wiki/Etretinate" title="Etretinate">Etretinate</a> </td> <td>1989 </td> <td>France </td> <td><a href="/wiki/Teratogen" class="mw-redirect" title="Teratogen">Teratogen</a>.<a href="#cite_note-Qureshi-2011-2">[2]</a><a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/w/index.php?title=Exifone&action=edit&redlink=1" class="new" title="Exifone (page does not exist)">Exifone</a> </td> <td>1989 </td> <td>France </td> <td>Hepatotoxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Fen-phen" class="mw-redirect" title="Fen-phen">Fen-phen</a> (popular combination of <a href="/wiki/Fenfluramine" title="Fenfluramine">fenfluramine</a> and <a href="/wiki/Phentermine" title="Phentermine">phentermine</a>) </td> <td>1997 </td> <td> </td> <td>Cardiotoxicity </td></tr> <tr> <td><a href="/wiki/Fenclofenac" title="Fenclofenac">Fenclofenac</a> </td> <td>1984 </td> <td>UK </td> <td>Cutaneous reactions; animal carcinogenicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Fenclozic_acid" title="Fenclozic acid">Fenclozic acid</a> </td> <td>1970 </td> <td>UK, US </td> <td>Hepatotoxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Fenfluramine" title="Fenfluramine">Fenfluramine</a> </td> <td>1997 </td> <td>European Union, UK, US, India, South Africa, others </td> <td>Cardiac valvular disease, pulmonary hypertension, cardiac fibrosis;<a href="#cite_note-Fung-2001-3">[3]</a><a href="#cite_note-23">[23]</a> re-approved in June 2020 for the treatment of seizures associated with <a href="/wiki/Dravet_syndrome" title="Dravet syndrome">Dravet syndrome</a>, under FDA <a href="/wiki/Orphan_drug" title="Orphan drug">orphan drug</a> rules. </td></tr> <tr> <td><a href="/wiki/Fenoterol" title="Fenoterol">Fenoterol</a> </td> <td>1990 </td> <td>New Zealand </td> <td>Asthma mortality.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Feprazone" title="Feprazone">Feprazone</a> </td> <td>1984 </td> <td>Germany, UK </td> <td>Cutaneous reaction, multiorgan toxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Fipexide" title="Fipexide">Fipexide</a> </td> <td>1991 </td> <td>France </td> <td>Hepatotoxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Flosequinan" title="Flosequinan">Flosequinan</a> (Manoplax) </td> <td>1993 </td> <td>UK, US </td> <td>Increased mortality at higher doses; increased hospitalizations.<a href="#cite_note-Qureshi-2011-2">[2]</a><a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Flunitrazepam" title="Flunitrazepam">Flunitrazepam</a> </td> <td>1991 </td> <td>France </td> <td>Abuse.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Flupirtine" title="Flupirtine">Flupirtine</a> </td> <td>2018 </td> <td>European Union </td> <td>Liver toxicity.<a href="#cite_note-24">[24]</a> </td></tr> <tr> <td><a href="/wiki/Gatifloxacin" title="Gatifloxacin">Gatifloxacin</a> </td> <td>2006 </td> <td>US </td> <td>Increased risk of dysglycemia.<a href="#cite_note-Qureshi-2011-2">[2]</a> </td></tr> <tr> <td><a href="/wiki/Gemtuzumab_ozogamicin" title="Gemtuzumab ozogamicin">Gemtuzumab ozogamicin</a> (Mylotarg) </td> <td>2010 </td> <td>US </td> <td>No improvement in clinical benefit; risk for death.<a href="#cite_note-Qureshi-2011-2">[2]</a> Returned to market in 2017.<a href="#cite_note-25">[25]</a> </td></tr> <tr> <td><a href="/wiki/Glafenine" title="Glafenine">Glafenine</a> </td> <td>1984 </td> <td>France, Germany </td> <td>Anaphylaxis.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Grepafloxacin" title="Grepafloxacin">Grepafloxacin</a> (Raxar) </td> <td>1999 </td> <td>Withdrawn Germany, UK, US others </td> <td>Cardiac repolarization; QT interval prolongation.<a href="#cite_note-Qureshi-2011-2">[2]</a> </td></tr> <tr> <td><a href="/wiki/Hydromorphone" title="Hydromorphone">Hydromorphone</a> (Palladone, extended release version) </td> <td>2005 </td> <td> </td> <td>High risk of accidental overdose when extended release version (Palladone) administered with <a href="/wiki/Alcohol_(drug)" title="Alcohol (drug)">alcohol</a>. Standard hydromorphone is sold in most of the world including the US </td></tr> <tr> <td><a href="/w/index.php?title=Ibufenac&action=edit&redlink=1" class="new" title="Ibufenac (page does not exist)">Ibufenac</a> </td> <td>1968 </td> <td>UK </td> <td>Hepatotoxicity, jaundice.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Indalpine" title="Indalpine">Indalpine</a> </td> <td>1985 </td> <td>France </td> <td>Agranulocytosis.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Indoprofen" title="Indoprofen">Indoprofen</a> </td> <td>1983 </td> <td>Germany, Spain, UK </td> <td>Animal carcinogenicity, gastrointestinal toxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Ingenol_mebutate_gel" class="mw-redirect" title="Ingenol mebutate gel">Ingenol mebutate gel</a> </td> <td>2020 </td> <td>Suspended in Europe </td> <td>Increased risk of skin cancers.<a href="#cite_note-26">[26]</a><a href="#cite_note-27">[27]</a> </td></tr> <tr> <td><a href="/w/index.php?title=Iodinated_casein_strophantin&action=edit&redlink=1" class="new" title="Iodinated casein strophantin (page does not exist)">Iodinated casein strophantin</a> </td> <td>1964 </td> <td>US </td> <td>Metabolic reaction.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Iproniazid" title="Iproniazid">Iproniazid</a> </td> <td>1964 </td> <td>Canada </td> <td>Interactions with food products containing tyrosine.<a href="#cite_note-28">[28]</a> </td></tr> <tr> <td><a href="/w/index.php?title=Isaxonine_phosphate&action=edit&redlink=1" class="new" title="Isaxonine phosphate (page does not exist)">Isaxonine phosphate</a> </td> <td>1984 </td> <td>France </td> <td>Hepatotoxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Isoxicam" title="Isoxicam">Isoxicam</a> </td> <td>1983 </td> <td>France, Germany, Spain, others </td> <td>Stevens–Johnson syndrome.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Kava_Kava" class="mw-redirect" title="Kava Kava">Kava Kava</a> </td> <td>2002 </td> <td>Germany </td> <td>Hepatotoxicity.<a href="#cite_note-Schubert-Zsilavecz-14">[14]</a> </td></tr> <tr> <td><a href="/wiki/Ketorolac" title="Ketorolac">Ketorolac</a> </td> <td>1993 </td> <td>France, Germany, others </td> <td>Hemorrhage, <a href="/wiki/Kidney_Failure" class="mw-redirect" title="Kidney Failure">Kidney Failure</a>.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/L-tryptophan" class="mw-redirect" title="L-tryptophan">L-tryptophan</a> </td> <td>1989 </td> <td>Germany, UK </td> <td>Eosinophilic myalgia syndrome.<a href="#cite_note-Fung-2001-3">[3]</a> Still sold in the US </td></tr> <tr> <td><a href="/wiki/Levamisole" title="Levamisole">Levamisole</a> (Ergamisol) </td> <td>1999 </td> <td>US </td> <td>Still used as veterinary drug and as a human antihelminthic in many markets; listed on the WHO List of Essential Medicines. In humans, it was used to treat melanoma before it was withdrawn for <a href="/wiki/Agranulocytosis" title="Agranulocytosis">agranulocytosis</a>.<a href="#cite_note-mmwr-29">[29]</a><a href="#cite_note-annals-30">[30]</a><a href="#cite_note-31">[31]</a> </td></tr> <tr> <td><a href="/wiki/Levomethadyl_acetate" class="mw-redirect" title="Levomethadyl acetate">Levomethadyl acetate</a> </td> <td>2003 </td> <td>US </td> <td>Cardiac arrhythmias and cardiac arrest.<a href="#cite_note-Qureshi-2011-2">[2]</a> </td></tr> <tr> <td><a href="/wiki/Lorcaserin" title="Lorcaserin">Lorcaserin</a> (Belviq) </td> <td>2020 </td> <td>US </td> <td>Increased risk of cancer.<a href="#cite_note-32">[32]</a> </td></tr> <tr> <td><a href="/wiki/Lumiracoxib" title="Lumiracoxib">Lumiracoxib</a> (Prexige) </td> <td>2007–2008 </td> <td>Worldwide </td> <td>Liver damage </td></tr> <tr> <td><a href="/wiki/Lysergic_acid_diethylamide" class="mw-redirect" title="Lysergic acid diethylamide">Lysergic acid diethylamide</a> (LSD) </td> <td>1950s–1960s </td> <td> </td> <td>Marketed as a psychiatric drug; withdrawn after it became widely used recreationally. Now illegal in most of the world. </td></tr> <tr> <td><a href="/wiki/Mebanazine" title="Mebanazine">Mebanazine</a> </td> <td>1975 </td> <td>UK </td> <td>Hepatotoxicity, drug intereaction.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Methandrostenolone" class="mw-redirect" title="Methandrostenolone">Methandrostenolone</a> </td> <td>1982 </td> <td>France, Germany, UK, US, others </td> <td>Off-label abuse.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Methapyrilene" title="Methapyrilene">Methapyrilene</a> </td> <td>1979 </td> <td>Germany, UK, US </td> <td>Animal carcinogenicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Methaqualone" title="Methaqualone">Methaqualone</a> </td> <td>1984 </td> <td>South Africa (1971), India (1984), United Nations (1971–1988) </td> <td>Withdrawn because of risk of <a href="/wiki/Substance_dependence" title="Substance dependence">addiction</a> and <a href="/wiki/Overdose" class="mw-redirect" title="Overdose">overdose</a><a href="#cite_note-CDSCO-India-33">[33]</a><a href="#cite_note-SAPS-Methaqualone-34">[34]</a> </td></tr> <tr> <td><a href="/wiki/Metipranolol" title="Metipranolol">Metipranolol</a> </td> <td>1990 </td> <td>UK, others </td> <td>Uveitis.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Metofoline" title="Metofoline">Metofoline</a> </td> <td>1965 </td> <td>US </td> <td>Unspecific experimental toxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Mibefradil" title="Mibefradil">Mibefradil</a> </td> <td>1998 </td> <td>European Union, Malaysia, US, others </td> <td>Fatal arrhythmia, drug interactions.<a href="#cite_note-Qureshi-2011-2">[2]</a><a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Minaprine" title="Minaprine">Minaprine</a> </td> <td>1996 </td> <td>France </td> <td>Convulsions.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Moxisylyte" title="Moxisylyte">Moxisylyte</a> </td> <td>1993 </td> <td>France </td> <td>Necrotic hepatitis.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Muzolimine" title="Muzolimine">Muzolimine</a> </td> <td>1987 </td> <td>France, Germany, European Union </td> <td>Polyneuropathy.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Natalizumab" title="Natalizumab">Natalizumab</a> (Tysabri) </td> <td>2005–2006 </td> <td>US </td> <td>Voluntarily withdrawn from US market because of risk of <a href="/wiki/Progressive_multifocal_leukoencephalopathy" title="Progressive multifocal leukoencephalopathy">Progressive multifocal leukoencephalopathy</a> (PML). Returned to market July 2006. </td></tr> <tr> <td><a href="/wiki/Nefazodone" title="Nefazodone">Nefazodone</a> </td> <td>2004 </td> <td>Europe, Australia, New Zealand and Canada<a href="#cite_note-35">[35]</a><a href="#cite_note-36">[36]</a><a href="#cite_note-37">[37]</a> </td> <td>Branded version withdrawn by originator in several countries in 2007 for hepatotoxicity. Generic versions available. Still available in US market. </td></tr> <tr> <td><a href="/wiki/Nialamide" title="Nialamide">Nialamide</a> </td> <td>1974 </td> <td>UK, US </td> <td>Hepatotoxicity, drug intereaction.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Nikethamide" title="Nikethamide">Nikethamide</a> </td> <td>1988 </td> <td>multiple markets </td> <td>CNS Stimulation.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/w/index.php?title=Nitrefazole&action=edit&redlink=1" class="new" title="Nitrefazole (page does not exist)">Nitrefazole</a> </td> <td>1984 </td> <td>Germany </td> <td>Hepatic and hematologic toxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Nomifensine" title="Nomifensine">Nomifensine</a> </td> <td>1981–1986 </td> <td>France, Germany, Spain, UK, US, others </td> <td>Hemolytic Anemia, hepatotoxicity, serious hypersensitive reactions.<a href="#cite_note-Qureshi-2011-2">[2]</a><a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Oxeladin" title="Oxeladin">Oxeladin</a> </td> <td>1976 </td> <td>Canada, UK, US (1976) </td> <td>Carcinogen.<a href="#cite_note-38">[38]</a> </td></tr> <tr> <td><a href="/wiki/Oxyphenbutazone" title="Oxyphenbutazone">Oxyphenbutazone</a> </td> <td>1984–1985 </td> <td>UK, US, Germany, France, Canada </td> <td>Bone marrow suppression, <a href="/wiki/Stevens%E2%80%93Johnson_syndrome" title="Stevens–Johnson syndrome">Stevens–Johnson syndrome</a>.<a href="#cite_note-Fung-2001-3">[3]</a><a href="#cite_note-39">[39]</a><a href="#cite_note-40">[40]</a> </td></tr> <tr> <td><a href="/wiki/Oxyphenisatin" class="mw-redirect" title="Oxyphenisatin">Oxyphenisatin</a> (Phenisatin) </td> <td>1970s </td> <td>Australia, France, Germany, UK, US </td> <td>Hepatotoxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Ozogamicin,_gemtuzumab" class="mw-redirect" title="Ozogamicin, gemtuzumab">Ozogamicin</a> </td> <td>2010 </td> <td>US </td> <td>No improvement in clinical benefit; risk for death; veno-occlusive disease.<a href="#cite_note-Qureshi-2011-2">[2]</a> </td></tr> <tr> <td><a href="/wiki/Pemoline" title="Pemoline">Pemoline</a> (Cylert) </td> <td>1997 </td> <td>Canada, UK </td> <td>Withdrawn from US in 2005 due to hepatotoxicity.<a href="#cite_note-41">[41]</a><a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Pentobarbital" title="Pentobarbital">Pentobarbital</a> </td> <td>1980 </td> <td>Norway </td> <td>Risk of fatal overdose.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Pentylenetetrazol" title="Pentylenetetrazol">Pentylenetetrazol</a> </td> <td>1982 </td> <td>US </td> <td>Withdrawn for inability to produce effective <a href="/wiki/Convulsive_therapy" class="mw-redirect" title="Convulsive therapy">convulsive therapy</a>, and for causing seizures. </td></tr> <tr> <td><a href="/wiki/Pergolide" title="Pergolide">Pergolide</a> (Permax) </td> <td>2007 </td> <td>US </td> <td>Risk for heart valve damage.<a href="#cite_note-Qureshi-2011-2">[2]</a> </td></tr> <tr> <td><a href="/wiki/Perhexiline" title="Perhexiline">Perhexiline</a> </td> <td>1985 </td> <td>UK, Spain </td> <td>Neurologic and hepatic toxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Phenacetin" title="Phenacetin">Phenacetin</a> </td> <td>1975 </td> <td>Canada </td> <td>An ingredient in "A.P.C." tablet; withdrawn because of risk of cancer and kidney disease<a href="#cite_note-42">[42]</a> Germany Denmark, UK, US, others Reason: nephropathy.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Phenformin" title="Phenformin">Phenformin</a> and <a href="/wiki/Buformin" title="Buformin">Buformin</a> </td> <td>1977 </td> <td>France, Germany US </td> <td>Severe <a href="/wiki/Lactic_acidosis" title="Lactic acidosis">lactic acidosis</a><a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Phenolphthalein" title="Phenolphthalein">Phenolphthalein</a> </td> <td>1997 </td> <td>US </td> <td>Possible carcinogen.<a href="#cite_note-Wysowski-2005-43">[43]</a> </td></tr> <tr> <td><a href="/wiki/Phenoxypropazine" title="Phenoxypropazine">Phenoxypropazine</a> </td> <td>1966 </td> <td>UK </td> <td>Hepatotoxicity, drug intereaction.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Phenylbutazone" title="Phenylbutazone">Phenylbutazone</a> </td> <td>1985 </td> <td>Germany </td> <td>Off-label abuse, hematologic toxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Phenylpropanolamine" title="Phenylpropanolamine">Phenylpropanolamine</a> (Propagest, <a href="/wiki/Dexatrim" title="Dexatrim">Dexatrim</a>) </td> <td>2000 </td> <td>Canada, US </td> <td>Hemorrhagic stroke.<a href="#cite_note-44">[44]</a><a href="#cite_note-45">[45]</a> </td></tr> <tr> <td><a href="/w/index.php?title=Pifoxime&action=edit&redlink=1" class="new" title="Pifoxime (page does not exist)">Pifoxime</a> (=<a href="/w/index.php?title=Pixifenide&action=edit&redlink=1" class="new" title="Pixifenide (page does not exist)">Pixifenide</a>) </td> <td>1976 </td> <td>France </td> <td>Neuropsychiatric reaction.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Pirprofen" title="Pirprofen">Pirprofen</a> </td> <td>1990 </td> <td>France, Germany, Spain </td> <td>Liver toxicity.<a href="#cite_note-Fung-2001-3">[3]</a><a href="#cite_note-WHO2005-12">[12]</a>: 223  </td></tr> <tr> <td><a href="/wiki/Prenylamine" title="Prenylamine">Prenylamine</a> </td> <td>1988 </td> <td>Canada, France, Germany, UK, US, others </td> <td>Cardiac arrhythmia<a href="#cite_note-46">[46]</a> and death.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Proglumide" title="Proglumide">Proglumide</a> </td> <td>1989 </td> <td>Germany </td> <td>Respiratory reaction.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Pronethalol" title="Pronethalol">Pronethalol</a> </td> <td>1965 </td> <td>UK </td> <td>Animal carcinogenicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Propanidid" title="Propanidid">Propanidid</a> </td> <td>1983 </td> <td>UK </td> <td>Allergy.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Proxibarbal" class="mw-redirect" title="Proxibarbal">Proxibarbal</a> </td> <td>1998 </td> <td>Spain, France, Italy, Portugal, Turkey </td> <td>Immunoallergic, thrombocytopenia.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Pyrovalerone" title="Pyrovalerone">Pyrovalerone</a> </td> <td>1979 </td> <td>France </td> <td>Abuse.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Ranitidine" title="Ranitidine">Ranitidine</a> (Zantac) </td> <td>2020 </td> <td>Worldwide </td> <td>Found to spontaneously break down into the carcinogen <a href="/wiki/N-Nitrosodimethylamine" title="N-Nitrosodimethylamine">N-nitrosodimethylamine</a>. </td></tr> <tr> <td><a href="/wiki/Rapacuronium" class="mw-redirect" title="Rapacuronium">Rapacuronium</a> (Raplon) </td> <td>2001 </td> <td>US, multiple markets </td> <td>Withdrawn in many countries because of risk of fatal <a href="/wiki/Bronchospasm" title="Bronchospasm">bronchospasm</a>.<a href="#cite_note-Qureshi-2011-2">[2]</a> </td></tr> <tr> <td><a href="/wiki/Remoxipride" title="Remoxipride">Remoxipride</a> </td> <td>1993 </td> <td>UK, others </td> <td>Aplastic anemia.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td>rhesus rotavirus vaccine-tetravalent (RotaShield) </td> <td>1999 </td> <td>US </td> <td>Withdrawn due to risk of <a href="/wiki/Intussusception_(medical_disorder)" title="Intussusception (medical disorder)">intussusception</a>.<a href="#cite_note-47">[47]</a> </td></tr> <tr> <td><a href="/wiki/Rimonabant" title="Rimonabant">Rimonabant</a> (Acomplia) </td> <td>2008 </td> <td>Worldwide </td> <td>Risk of severe depression and suicide.<a href="#cite_note-Schubert-Zsilavecz-14">[14]</a> </td></tr> <tr> <td><a href="/wiki/Rofecoxib" title="Rofecoxib">Rofecoxib</a> (<a href="/wiki/Vioxx" class="mw-redirect" title="Vioxx">Vioxx</a>) </td> <td>2004 </td> <td>Worldwide </td> <td>Withdrawn by <a href="/wiki/Merck_%26_Co." title="Merck & Co.">Merck & Co</a>. Risk of <a href="/wiki/Myocardial_infarction" title="Myocardial infarction">myocardial infarction</a> and stroke.<a href="#cite_note-Qureshi-2011-2">[2]</a> </td></tr> <tr> <td><a href="/wiki/Rosiglitazone" title="Rosiglitazone">Rosiglitazone</a> (Avandia) </td> <td>2010 </td> <td>Europe </td> <td>Risk of heart attacks and death. This drug continues to be available in the US </td></tr> <tr> <td><a href="/wiki/Secobarbital" title="Secobarbital">Secobarbital</a> </td> <td> </td> <td>France, Norway, others. </td> <td>Risk of overdose<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Sertindole" title="Sertindole">Sertindole</a> </td> <td>1998 </td> <td>European Union </td> <td>Arrhythmia and sudden cardiac death<a href="#cite_note-Fung-2001-3">[3]</a><a href="#cite_note-48">[48]</a> </td></tr> <tr> <td><a href="/wiki/Sibutramine" title="Sibutramine">Sibutramine</a> (Reductil/Meridia) </td> <td>2010 </td> <td>Australia,<a href="#cite_note-49">[49]</a> Canada,<a href="#cite_note-50">[50]</a> China,<a href="#cite_note-51">[51]</a> the European Union (EU),<a href="#cite_note-52">[52]</a> Hong Kong,<a href="#cite_note-53">[53]</a> India,<a href="#cite_note-54">[54]</a> Mexico, New Zealand,<a href="#cite_note-55">[55]</a> the Philippines,<a href="#cite_note-56">[56]</a> Thailand,<a href="#cite_note-57">[57]</a> the United Kingdom,<a href="#cite_note-58">[58]</a> and the United States<a href="#cite_note-wsj-59">[59]</a> </td> <td>Increased risk of heart attack and stroke.<a href="#cite_note-Qureshi-2011-2">[2]</a> </td></tr> <tr> <td><a href="/wiki/Sitaxentan" title="Sitaxentan">Sitaxentan</a> </td> <td>2010 </td> <td>Germany </td> <td>Hepatotoxicity.<a href="#cite_note-Schubert-Zsilavecz-14">[14]</a> </td></tr> <tr> <td><a href="/wiki/Sorivudine" title="Sorivudine">Sorivudine</a> </td> <td>1993 </td> <td>Japan </td> <td>Drug interaction and deaths.<a href="#cite_note-60">[60]</a> </td></tr> <tr> <td><a href="/wiki/Sparfloxacin" title="Sparfloxacin">Sparfloxacin</a> </td> <td>2001 </td> <td>US </td> <td>QT prolongation and phototoxicity.<a href="#cite_note-Qureshi-2011-2">[2]</a> </td></tr> <tr> <td><a href="/w/index.php?title=Sulfacarbamide&action=edit&redlink=1" class="new" title="Sulfacarbamide (page does not exist)">Sulfacarbamide</a> </td> <td>1988 </td> <td>Germany </td> <td>Dermatologic, hematologic and hepatic reactions.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Sulfamethoxydiazine" class="mw-redirect" title="Sulfamethoxydiazine">Sulfamethoxydiazine</a> </td> <td>1988 </td> <td>Germany </td> <td>Unknown.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Sulfamethoxypyridazine" title="Sulfamethoxypyridazine">Sulfamethoxypyridazine</a> </td> <td>1986 </td> <td>UK </td> <td>Dermatologic and hematologic reactions.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Suloctidil" title="Suloctidil">Suloctidil</a> </td> <td>1985 </td> <td>Germany, France, Spain </td> <td>Hepatotoxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Suprofen" title="Suprofen">Suprofen</a> </td> <td>1986–1987 </td> <td>UK, Spain, US </td> <td>Kidney damage.<a href="#cite_note-Qureshi-2011-2">[2]</a><a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Tegaserod" title="Tegaserod">Tegaserod</a> (Zelnorm) </td> <td>2007 </td> <td>US </td> <td>Risk for heart attack, stroke, and unstable angina.<a href="#cite_note-Qureshi-2011-2">[2]</a> Was available through a restricted access program until April 2008; returned to market in 2019. </td></tr> <tr> <td><a href="/wiki/Temafloxacin" title="Temafloxacin">Temafloxacin</a> </td> <td>1992 </td> <td>Germany, UK, US, others </td> <td>Low blood sugar; hemolytic anemia; kidney, liver dysfunction; allergic reactions<a href="#cite_note-Qureshi-2011-2">[2]</a><a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Temafloxacin" title="Temafloxacin">Temafloxacin</a> </td> <td>1992 </td> <td>US </td> <td>Allergic reactions and cases of <a href="/wiki/Hemolytic_anemia" title="Hemolytic anemia">hemolytic anemia</a>, leading to three patient deaths.<a rel="nofollow" class="external autonumber" href="https://www.fda.gov/bbs/topics/NEWS/NEW00279.html">[2]</a> </td></tr> <tr> <td><a href="/wiki/Temazepam" title="Temazepam">Temazepam</a> (Restoril, Euhypnos, Normison, Remestan, Tenox, Norkotral) </td> <td>1999 </td> <td>Sweden, Norway </td> <td>Diversion, abuse, and a relatively high rate of overdose deaths in comparison to other drugs of its group. This drug continues to be available in most of the world including the US, but under strict controls. </td></tr> <tr> <td><a href="/wiki/Terfenadine" title="Terfenadine">Terfenadine</a> (Seldane, Triludan) </td> <td>1997–1998 </td> <td>France, South Africa, Oman, others, US </td> <td>Prolonged QT interval; <a href="/wiki/Ventricular_tachycardia" title="Ventricular tachycardia">ventricular tachycardia</a><a href="#cite_note-Qureshi-2011-2">[2]</a><a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Terodiline" title="Terodiline">Terodiline</a> (Micturin) </td> <td>1991 </td> <td>Germany, UK, Spain, others </td> <td>Prolonged QT interval, ventricular tachycardia and arrhythmia.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Tetrazepam" title="Tetrazepam">Tetrazepam</a> </td> <td>2013 </td> <td>European Union </td> <td>Serious cutaneous reactions.<a href="#cite_note-61">[61]</a> </td></tr> <tr> <td><a href="/wiki/Thalidomide" title="Thalidomide">Thalidomide</a> </td> <td>1961 </td> <td>Germany </td> <td>Withdrawn because of risk of <a href="/wiki/Teratogenesis" class="mw-redirect" title="Teratogenesis">teratogenicity</a>;<a href="#cite_note-62">[62]</a> returned to market for use in <a href="/wiki/Leprosy" title="Leprosy">leprosy</a> and <a href="/wiki/Multiple_myeloma" title="Multiple myeloma">multiple myeloma</a> under FDA <a href="/wiki/Orphan_drug" title="Orphan drug">orphan drug</a> rules </td></tr> <tr> <td><a href="/wiki/Thenalidine" title="Thenalidine">Thenalidine</a> </td> <td>1963 </td> <td>Canada, UK, US </td> <td>Neutropenia<a href="#cite_note-Fung-2001-3">[3]</a><a href="#cite_note-63">[63]</a> </td></tr> <tr> <td><a href="/wiki/Thiobutabarbitone" class="mw-redirect" title="Thiobutabarbitone">Thiobutabarbitone</a> </td> <td>1993 </td> <td>Germany </td> <td>Kidney injury.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Thioridazine" title="Thioridazine">Thioridazine</a> (Melleril) </td> <td>2005 </td> <td>Germany, UK </td> <td>Withdrawn worldwide due to severe cardiac arrhythmias<a href="#cite_note-PDS2012-64">[64]</a><a href="#cite_note-NHS-65">[65]</a> Continues to be available in Russia. </td></tr> <tr> <td><a href="/wiki/Ticrynafen" class="mw-redirect" title="Ticrynafen">Ticrynafen</a> (Tienilic acid) </td> <td>1980 </td> <td>Germany, France, UK, US others </td> <td>Liver toxicity and death.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Tolcapone" title="Tolcapone">Tolcapone</a> (Tasmar) </td> <td>1998 </td> <td>European Union, Canada, Australia </td> <td>Hepatotoxicity<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Tolrestat" title="Tolrestat">Tolrestat</a> (Alredase) </td> <td>1996 </td> <td>Argentina, Canada, Italy, others </td> <td>Severe hepatotoxicity<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/w/index.php?title=Triacetyldiphenolisatin&action=edit&redlink=1" class="new" title="Triacetyldiphenolisatin (page does not exist)">Triacetyldiphenolisatin</a> </td> <td>1971 </td> <td>Australia </td> <td>Hepatotoxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Triazolam" title="Triazolam">Triazolam</a> </td> <td>1991 </td> <td>France, Netherlands, Finland, Argentina, UK others </td> <td>Psychiatric adverse drug reactions, amnesia.<a href="#cite_note-Fung-2001-3">[3]</a><a href="#cite_note-66">[66]</a> </td></tr> <tr> <td><a href="/wiki/Triparanol" title="Triparanol">Triparanol</a> </td> <td>1962 </td> <td>France, US </td> <td>Cataracts, alopecia, ichthyosis.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Troglitazone" title="Troglitazone">Troglitazone</a> (Rezulin) </td> <td>2000 </td> <td>US, Germany </td> <td><a href="/wiki/Hepatotoxicity" title="Hepatotoxicity">Hepatotoxicity</a><a href="#cite_note-Qureshi-2011-2">[2]</a> </td></tr> <tr> <td><a href="/wiki/Trovafloxacin" title="Trovafloxacin">Trovafloxacin</a> (Trovan) </td> <td>1999–2001 </td> <td>European Union, US </td> <td>Withdrawn because of risk of <a href="/wiki/Liver_failure" title="Liver failure">liver failure</a><a href="#cite_note-Qureshi-2011-2">[2]</a><a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Valdecoxib" title="Valdecoxib">Valdecoxib</a> (Bextra) </td> <td>2004 </td> <td>US </td> <td>Risk of heart attack and stroke.<a href="#cite_note-Qureshi-2011-2">[2]</a> </td></tr> <tr> <td><a href="/wiki/Vincamine" title="Vincamine">Vincamine</a> </td> <td>1987 </td> <td>Germany </td> <td>Hematologic toxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/w/index.php?title=Xenazoic_acid&action=edit&redlink=1" class="new" title="Xenazoic acid (page does not exist)">Xenazoic acid</a> </td> <td>1965 </td> <td>France </td> <td>Hepatotoxicity.<a href="#cite_note-Fung-2001-3">[3]</a> </td></tr> <tr> <td><a href="/wiki/Ximelagatran" title="Ximelagatran">Ximelagatran</a> (Exanta) </td> <td>2006 </td> <td>Germany </td> <td>Hepatotoxicity<a href="#cite_note-Schubert-Zsilavecz-14">[14]</a> </td></tr> <tr> <td><a href="/wiki/Zimelidine" title="Zimelidine">Zimelidine</a> </td> <td>1983 </td> <td>Worldwide </td> <td>Risk of <a href="/wiki/Guillain%E2%80%93Barr%C3%A9_syndrome" title="Guillain–Barré syndrome">Guillain–Barré syndrome</a>, hypersensitivity reaction, hepatotoxicity<a href="#cite_note-Fung-2001-3">[3]</a><a href="#cite_note-Fagius-67">[67]</a><a href="#cite_note-68">[68]</a> banned worldwide.<a href="#cite_note-69">[69]</a> </td></tr> <tr> <td><a href="/wiki/Zomepirac" title="Zomepirac">Zomepirac</a> </td> <td>1983 </td> <td>UK, Germany, Spain, US </td> <td><a href="/wiki/Anaphylactic_reactions" class="mw-redirect" title="Anaphylactic reactions">Anaphylactic reactions</a> and non-fatal allergic reactions, kidney failure<a href="#cite_note-Qureshi-2011-2">[2]</a><a href="#cite_note-Fung-2001-3">[3]</a> </td></tr></tbody></table> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2>[<a href="/w/index.php?title=List_of_withdrawn_drugs&action=edit&section=2" title="Edit section: See also">edit</a>]</div> <ul><li><a href="/wiki/Adverse_drug_reaction" title="Adverse drug reaction">Adverse drug reaction</a></li> <li><a href="/wiki/Adverse_events" class="mw-redirect" title="Adverse events">Adverse events</a></li> <li><a href="/wiki/European_Medicines_Agency" title="European Medicines Agency">European Medicines Agency</a></li> <li><a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2>[<a href="/w/index.php?title=List_of_withdrawn_drugs&action=edit&section=3" title="Edit section: References">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-1"><a href="#cite_ref-1">^</a> <style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon 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.citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFBranch" class="citation web cs1">Branch, Government of Canada, Health Canada, Public Affairs, Consultation and Communications. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20050628074032/http://www.hc-sc.gc.ca/english/protection/warnings/2005/2005_01.html">"Health Canada – Home Page"</a>. Archived from <a rel="nofollow" class="external text" href="http://www.hc-sc.gc.ca/english/protection/warnings/2005/2005_01.html">the original</a> on 28 June 2005. Retrieved 28 November 2016.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Health+Canada+%E2%80%93+Home+Page&rft.aulast=Branch&rft.aufirst=Government+of+Canada%2C+Health+Canada%2C+Public+Affairs%2C+Consultation+and+Communications&rft_id=http%3A%2F%2Fwww.hc-sc.gc.ca%2Fenglish%2Fprotection%2Fwarnings%2F2005%2F2005_01.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3AList+of+withdrawn+drugs" class="Z3988"><code class="cs1-code">{{<a href="/wiki/Template:Cite_web" title="Template:Cite web">cite web</a>}}</code>: CS1 maint: multiple names: authors list (<a href="/wiki/Category:CS1_maint:_multiple_names:_authors_list" title="Category:CS1 maint: multiple names: authors list">link</a>) </li> <li id="cite_note-Qureshi-2011-2">^ <a href="#cite_ref-Qureshi-2011_2-0">a</a> <a href="#cite_ref-Qureshi-2011_2-1">b</a> <a href="#cite_ref-Qureshi-2011_2-2">c</a> <a href="#cite_ref-Qureshi-2011_2-3">d</a> <a href="#cite_ref-Qureshi-2011_2-4">e</a> <a href="#cite_ref-Qureshi-2011_2-5">f</a> <a href="#cite_ref-Qureshi-2011_2-6">g</a> <a href="#cite_ref-Qureshi-2011_2-7">h</a> <a href="#cite_ref-Qureshi-2011_2-8">i</a> <a href="#cite_ref-Qureshi-2011_2-9">j</a> <a href="#cite_ref-Qureshi-2011_2-10">k</a> <a href="#cite_ref-Qureshi-2011_2-11">l</a> <a href="#cite_ref-Qureshi-2011_2-12">m</a> <a href="#cite_ref-Qureshi-2011_2-13">n</a> <a href="#cite_ref-Qureshi-2011_2-14">o</a> <a href="#cite_ref-Qureshi-2011_2-15">p</a> <a href="#cite_ref-Qureshi-2011_2-16">q</a> <a href="#cite_ref-Qureshi-2011_2-17">r</a> <a href="#cite_ref-Qureshi-2011_2-18">s</a> <a href="#cite_ref-Qureshi-2011_2-19">t</a> <a href="#cite_ref-Qureshi-2011_2-20">u</a> <a href="#cite_ref-Qureshi-2011_2-21">v</a> <a href="#cite_ref-Qureshi-2011_2-22">w</a> <a href="#cite_ref-Qureshi-2011_2-23">x</a> <a href="#cite_ref-Qureshi-2011_2-24">y</a> <a href="#cite_ref-Qureshi-2011_2-25">z</a> <a href="#cite_ref-Qureshi-2011_2-26">aa</a> <a href="#cite_ref-Qureshi-2011_2-27">ab</a> <a href="#cite_ref-Qureshi-2011_2-28">ac</a> <a href="#cite_ref-Qureshi-2011_2-29">ad</a> <a href="#cite_ref-Qureshi-2011_2-30">ae</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFQureshiSeoane-Vazquez,_ERodriguez-Monguio,_RStevenson,_KB2011" class="citation journal cs1">Qureshi, ZP; Seoane-Vazquez, E; Rodriguez-Monguio, R; Stevenson, KB; Szeinbach, SL (July 2011). 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Retrieved 24 September 2013.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Dantron&rft.au=DrugBank&rft_id=http%3A%2F%2Fwww.drugbank.ca%2Fdrugs%2FDB04816&rfr_id=info%3Asid%2Fen.wikipedia.org%3AList+of+withdrawn+drugs" class="Z3988"> </li> <li id="cite_note-16"><a href="#cite_ref-16">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm234350.htm">"Press Announcements – Xanodyne agrees to withdraw propoxyphene from the U.S. market"</a>. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20161113155019/https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm234350.htm">Archived</a> from the original on 13 November 2016. Retrieved 28 November 2016.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Food+and+Drug+Administration&rft.atitle=Press+Announcements+%E2%80%93+Xanodyne+agrees+to+withdraw+propoxyphene+from+the+U.S.+market&rft_id=https%3A%2F%2Fwww.fda.gov%2FNewsEvents%2FNewsroom%2FPressAnnouncements%2Fucm234350.htm&rfr_id=info%3Asid%2Fen.wikipedia.org%3AList+of+withdrawn+drugs" class="Z3988"> </li> <li id="cite_note-DODTox-17">^ <a href="#cite_ref-DODTox_17-0">a</a> <a href="#cite_ref-DODTox_17-1">b</a> Col John Lammie et al. <a rel="nofollow" class="external text" href="http://home.fhpr.osd.mil/Libraries/pdf/Report_of_the_DoD_DMAA_Safety_Review_Panel_2013.sflb.ashx">Report of the Department Of Defense: 1,3 Dimethylamylamine (Dmaa) Safety Review Panel</a> <a rel="nofollow" class="external text" href="https://web.archive.org/web/20140119112259/http://home.fhpr.osd.mil/Libraries/pdf/Report_of_the_DoD_DMAA_Safety_Review_Panel_2013.sflb.ashx">Archived</a> 2014-01-19 at the <a href="/wiki/Wayback_Machine" title="Wayback Machine">Wayback Machine</a> June 3, 2013 </li> <li id="cite_note-18"><a href="#cite_ref-18">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFDA" class="citation web cs1">FDA. <a rel="nofollow" class="external text" href="https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm347270.htm">"Stimulant Potentially Dangerous to Health, FDA Warns"</a>. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20140201191226/https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm347270.htm">Archived</a> from the original on 1 February 2014. Retrieved 26 January 2014.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Food+and+Drug+Administration&rft.atitle=Stimulant+Potentially+Dangerous+to+Health%2C+FDA+Warns&rft.au=FDA&rft_id=https%3A%2F%2Fwww.fda.gov%2FForConsumers%2FConsumerUpdates%2Fucm347270.htm&rfr_id=info%3Asid%2Fen.wikipedia.org%3AList+of+withdrawn+drugs" class="Z3988"> </li> <li id="cite_note-19"><a href="#cite_ref-19">^</a> <a rel="nofollow" class="external text" href="http://www.nejm.org/doi/full/10.1056/NEJMoa1202290">Drotrecogin Alfa (Activated) in Adults with Septic Shock </a> <a rel="nofollow" class="external text" href="https://web.archive.org/web/20150929001734/http://www.nejm.org/doi/full/10.1056/NEJMoa1202290">Archived</a> 2015-09-29 at the <a href="/wiki/Wayback_Machine" title="Wayback Machine">Wayback Machine</a>, N Engl J Med 2012; 366:2055–2064, May 31, 2012, <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMoa1202290">10.1056/NEJMoa1202290</a> </li> <li id="cite_note-20"><a href="#cite_ref-20">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20111028112048/http://www.ema.europa.eu/ema/index.jsp?curl=pages%2Fnews_and_events%2Fnews%2F2011%2F10%2Fnews_detail_001373.jsp&mid=WC0b01ac058004d5c1">"Xigris (drotrecogin alfa (activated)) to be withdrawn due to lack of efficacy"</a>. Press release. London, UK: European Medicines Agency. 25 October 2011. Archived from <a rel="nofollow" class="external text" href="http://www.ema.europa.eu/ema/index.jsp?curl=pages%2Fnews_and_events%2Fnews%2F2011%2F10%2Fnews_detail_001373.jsp&mid=WC0b01ac058004d5c1">the original</a> on 28 October 2011. Retrieved 26 October 2011.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Press+release&rft.atitle=Xigris+%28drotrecogin+alfa+%28activated%29%29+to+be+withdrawn+due+to+lack+of+efficacy&rft.date=2011-10-25&rft_id=http%3A%2F%2Fwww.ema.europa.eu%2Fema%2Findex.jsp%3Fcurl%3Dpages%252Fnews_and_events%252Fnews%252F2011%252F10%252Fnews_detail_001373.jsp%26mid%3DWC0b01ac058004d5c1&rfr_id=info%3Asid%2Fen.wikipedia.org%3AList+of+withdrawn+drugs" class="Z3988"> </li> <li id="cite_note-21"><a href="#cite_ref-21">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFArmstrong2011" class="citation web cs1">Armstrong, Drew (25 October 2011). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20111029155823/http://www.businessweek.com/news/2011-10-25/lilly-pulls-xigris-off-markets-after-sepsis-drug-fails-study.html">"Lilly Pulls Xigris Off Markets After Sepsis Drug Fails Study"</a>. Bloomberg Businessweek. Archived from <a rel="nofollow" class="external text" href="http://www.businessweek.com/news/2011-10-25/lilly-pulls-xigris-off-markets-after-sepsis-drug-fails-study.html">the original</a> on 2011-10-29. Retrieved 2011-10-25.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Bloomberg+Businessweek&rft.atitle=Lilly+Pulls+Xigris+Off+Markets+After+Sepsis+Drug+Fails+Study&rft.date=2011-10-25&rft.aulast=Armstrong&rft.aufirst=Drew&rft_id=http%3A%2F%2Fwww.businessweek.com%2Fnews%2F2011-10-25%2Flilly-pulls-xigris-off-markets-after-sepsis-drug-fails-study.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3AList+of+withdrawn+drugs" class="Z3988"> </li> <li id="cite_note-22"><a href="#cite_ref-22">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDrugBank" class="citation web cs1">DrugBank. <a rel="nofollow" class="external text" href="http://www.drugbank.ca/drugs/DB04827">"Ethyl carbamate"</a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20130927055159/http://www.drugbank.ca/drugs/DB04827">Archived</a> from the original on 27 September 2013. Retrieved 24 September 2013.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Ethyl+carbamate&rft.au=DrugBank&rft_id=http%3A%2F%2Fwww.drugbank.ca%2Fdrugs%2FDB04827&rfr_id=info%3Asid%2Fen.wikipedia.org%3AList+of+withdrawn+drugs" class="Z3988"> </li> <li id="cite_note-23"><a href="#cite_ref-23">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDrugBank" class="citation web cs1">DrugBank. <a rel="nofollow" class="external text" href="http://www.drugbank.ca/drugs/DB00574">"Fenfluramine"</a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20130927055055/http://www.drugbank.ca/drugs/DB00574">Archived</a> from the original on 27 September 2013. Retrieved 24 September 2013.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Fenfluramine&rft.au=DrugBank&rft_id=http%3A%2F%2Fwww.drugbank.ca%2Fdrugs%2FDB00574&rfr_id=info%3Asid%2Fen.wikipedia.org%3AList+of+withdrawn+drugs" class="Z3988"> </li> <li id="cite_note-24"><a href="#cite_ref-24">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2018/03/news_detail_002930.jsp&mid=WC0b01ac058004d5c1">"Withdrawal of pain medicine flupirtine endorsed"</a>. Retrieved 13 July 2018.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Withdrawal+of+pain+medicine+flupirtine+endorsed&rft_id=http%3A%2F%2Fwww.ema.europa.eu%2Fema%2Findex.jsp%3Fcurl%3Dpages%2Fnews_and_events%2Fnews%2F2018%2F03%2Fnews_detail_002930.jsp%26mid%3DWC0b01ac058004d5c1&rfr_id=info%3Asid%2Fen.wikipedia.org%3AList+of+withdrawn+drugs" class="Z3988"> </li> <li id="cite_note-25"><a href="#cite_ref-25">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFDA" class="citation web cs1">FDA. <a rel="nofollow" class="external text" href="https://www.fda.gov/news-events/press-announcements/fda-approves-mylotarg-treatment-acute-myeloid-leukemia">"FDA approves Mylotarg for treatment of acute myeloid leukemia"</a>. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a>. 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Retrieved 24 September 2013.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Iproniazid&rft.au=DrugBank&rft_id=http%3A%2F%2Fwww.drugbank.ca%2Fdrugs%2FDB04818&rfr_id=info%3Asid%2Fen.wikipedia.org%3AList+of+withdrawn+drugs" class="Z3988"> </li> <li id="cite_note-mmwr-29"><a href="#cite_ref-mmwr_29-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCenters_for_Disease_Control_and_Prevention_(CDC)2009" class="citation journal cs1">Centers for Disease Control and Prevention (CDC) (December 2009). <a rel="nofollow" class="external text" href="https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5849a3.htm">"Agranulocytosis associated with cocaine use – four States, March 2008 – November 2009"</a>. Morb. Mortal. Wkly. 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Pharmacoepidemiology and Drug Safety. 21 (11): 1227–1231. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fpds.3346">10.1002/pds.3346</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22941581">22941581</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:19560432">19560432</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=Outcome+of+patients+after+market+withdrawal+of+thioridazine%3A+A+retrospective+analysis+in+a+nationwide+cohort&rft.volume=21&rft.issue=11&rft.pages=1227-1231&rft.date=2012-11&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A19560432%23id-name%3DS2CID&rft_id=info%3Apmid%2F22941581&rft_id=info%3Adoi%2F10.1002%2Fpds.3346&rft.au=Purhonen%2C+M&rft.au=Koponen%2C+H&rft.au=Tiihonen%2C+J&rft.au=Tanskanen%2C+A&rfr_id=info%3Asid%2Fen.wikipedia.org%3AList+of+withdrawn+drugs" class="Z3988"> </li> <li id="cite_note-NHS-65"><a href="#cite_ref-NHS_65-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20150518080549/http://www.ljf.scot.nhs.uk/SharedCareofMedicines/Shared%20Care%20Agreements/SCA/SCA%20Thioridazine%20v1%200%20Final.pdf">"SHARED CARE PROTOCOL Thioridazine"</a> (PDF). NHS Lothian Joint Formulary. March 2012. Archived from <a rel="nofollow" class="external text" href="http://www.ljf.scot.nhs.uk/SharedCareofMedicines/Shared%20Care%20Agreements/SCA/SCA%20Thioridazine%20v1%200%20Final.pdf">the original</a> (PDF) on 2015-05-18.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=NHS+Lothian+Joint+Formulary&rft.atitle=SHARED+CARE+PROTOCOL+Thioridazine&rft.date=2012-03&rft_id=http%3A%2F%2Fwww.ljf.scot.nhs.uk%2FSharedCareofMedicines%2FShared%2520Care%2520Agreements%2FSCA%2FSCA%2520Thioridazine%2520v1%25200%2520Final.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3AList+of+withdrawn+drugs" class="Z3988"> </li> <li id="cite_note-66"><a href="#cite_ref-66">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDrugBank" class="citation web cs1">DrugBank. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20130927041923/http://www.drugbank.ca/drugs/DB00897">"Triazolam"</a>. Archived from <a rel="nofollow" class="external text" href="http://www.drugbank.ca/drugs/DB00897">the original</a> on 27 September 2013. Retrieved 24 September 2013.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Triazolam&rft.au=DrugBank&rft_id=http%3A%2F%2Fwww.drugbank.ca%2Fdrugs%2FDB00897&rfr_id=info%3Asid%2Fen.wikipedia.org%3AList+of+withdrawn+drugs" class="Z3988"> </li> <li id="cite_note-Fagius-67"><a href="#cite_ref-Fagius_67-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFagiusOstermanSidénWiholm1985" class="citation journal cs1">Fagius, J.; Osterman, P. O.; Sidén, A.; Wiholm, B. E. (1985). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1028185">"Guillain-Barré syndrome following zimeldine treatment"</a>. Journal of Neurology, Neurosurgery, and Psychiatry. 48 (1): 65–69. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1136%2Fjnnp.48.1.65">10.1136/jnnp.48.1.65</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1028185">1028185</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3156214">3156214</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Neurology%2C+Neurosurgery%2C+and+Psychiatry&rft.atitle=Guillain-Barr%C3%A9+syndrome+following+zimeldine+treatment&rft.volume=48&rft.issue=1&rft.pages=65-69&rft.date=1985&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1028185%23id-name%3DPMC&rft_id=info%3Apmid%2F3156214&rft_id=info%3Adoi%2F10.1136%2Fjnnp.48.1.65&rft.aulast=Fagius&rft.aufirst=J.&rft.au=Osterman%2C+P.+O.&rft.au=Sid%C3%A9n%2C+A.&rft.au=Wiholm%2C+B.+E.&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1028185&rfr_id=info%3Asid%2Fen.wikipedia.org%3AList+of+withdrawn+drugs" class="Z3988"> </li> <li id="cite_note-68"><a href="#cite_ref-68">^</a> <a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504589&viewopt=PubChem">Pubchem record</a> <a rel="nofollow" class="external text" href="https://web.archive.org/web/20150610232146/http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504589&viewopt=PubChem">Archived</a> 2015-06-10 at the <a href="/wiki/Wayback_Machine" title="Wayback Machine">Wayback Machine</a> says "withdrawn in 1983" </li> <li id="cite_note-69"><a href="#cite_ref-69">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDrugBank" class="citation web cs1">DrugBank. <a rel="nofollow" class="external text" href="http://www.drugbank.ca/drugs/DB04832">"Zimelidine"</a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20130927055154/http://www.drugbank.ca/drugs/DB04832">Archived</a> from the original on 27 September 2013. Retrieved 24 September 2013.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Zimelidine&rft.au=DrugBank&rft_id=http%3A%2F%2Fwww.drugbank.ca%2Fdrugs%2FDB04832&rfr_id=info%3Asid%2Fen.wikipedia.org%3AList+of+withdrawn+drugs" class="Z3988"> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2>[<a href="/w/index.php?title=List_of_withdrawn_drugs&action=edit&section=4" title="Edit section: External links">edit</a>]</div> <ul><li><a rel="nofollow" class="external text" href="https://www.fda.gov/downloads/AboutFDA/CentersOffices/CDER/WhatWeDo/UCM078935.pdf">CDER Report to the Nation: 2005</a> Has a list of US withdrawals through 2005.</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output 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abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Vaccines" title="Template:Vaccines"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Vaccines" title="Template talk:Vaccines"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Vaccines" title="Special:EditPage/Template:Vaccines"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Artificial_induction_of_immunity_/_Immunization:_Vaccines,_Vaccination,_Infection,_Inoculation_(J07)" style="font-size:114%;margin:0 4em"><a href="/wiki/Artificial_induction_of_immunity" title="Artificial induction of immunity">Artificial induction of immunity</a> / <a href="/wiki/Immunization" title="Immunization">Immunization</a>: <a href="/wiki/Vaccine" title="Vaccine">Vaccines</a>, <a href="/wiki/Vaccination" title="Vaccination">Vaccination</a>, <a href="/wiki/Infection" title="Infection">Infection</a>, <a href="/wiki/Inoculation" title="Inoculation">Inoculation</a> (<a href="/wiki/ATC_code_J07" title="ATC code J07">J07</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Development</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Immunologic_adjuvant" title="Immunologic adjuvant">Adjuvants</a></li> <li><a href="/wiki/Vaccine_ingredients" title="Vaccine ingredients">Vaccine ingredients</a> <ul><li><a href="/wiki/List_of_vaccine_excipients" title="List of vaccine excipients">list</a></li></ul></li> <li><a href="/wiki/Mathematical_modelling_of_infectious_diseases" title="Mathematical modelling of infectious diseases">Mathematical modelling</a></li> <li><a href="/wiki/Vaccine_storage" title="Vaccine storage">Storage</a></li> <li><a href="/wiki/Timeline_of_human_vaccines" title="Timeline of human vaccines">Timeline</a></li> <li><a href="/wiki/Vaccine_trial" title="Vaccine trial">Trials</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Classes</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Conjugate_vaccine" title="Conjugate vaccine">Conjugate</a></li> <li><a href="/wiki/Inactivated_vaccine" title="Inactivated vaccine">Inactivated</a></li> <li>Live <ul><li><a href="/wiki/Attenuated_vaccine" title="Attenuated vaccine">Attenuated</a></li> <li><a href="/wiki/Heterologous_vaccine" title="Heterologous vaccine">Heterologous</a></li></ul></li> <li><a href="/wiki/Subunit_vaccine" title="Subunit vaccine">Subunit/component</a> / <a href="/wiki/Peptide_vaccine" title="Peptide vaccine">Peptide</a> / <a href="/wiki/Virus-like_particle" title="Virus-like particle">Virus-like particle</a> / <a href="/wiki/Synthetic_vaccine" title="Synthetic vaccine">Synthetic</a></li> <li><a href="/wiki/DNA_vaccine" title="DNA vaccine">DNA</a> / <a href="/wiki/MRNA_vaccine" title="MRNA vaccine">mRNA</a></li> <li><a href="/wiki/Therapeutic_vaccines" title="Therapeutic vaccines">Therapeutic</a></li> <li><a href="/wiki/Toxoid" title="Toxoid">Toxoid</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Administration</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>Global: <ul><li><a href="/wiki/GAVI" title="GAVI">GAVI Alliance</a></li> <li><a href="/wiki/National_Immunization_Technical_Advisory_Group" title="National Immunization Technical Advisory Group">NITAG</a></li> <li><a href="/wiki/Strategic_Advisory_Group_of_Experts" title="Strategic Advisory Group of Experts">SAGE</a></li> <li><a href="/wiki/Vaccine_wastage" title="Vaccine wastage">Vaccine wastage</a></li> <li><a href="/wiki/Vaccination_policy" title="Vaccination policy">Policy</a></li> <li><a href="/wiki/Vaccination_schedule" title="Vaccination schedule">Schedule</a></li> <li><a href="/wiki/Vaccine_adverse_event" title="Vaccine adverse event">Vaccine injury</a></li></ul></li> <li>US: <ul><li><a href="/wiki/Advisory_Committee_on_Immunization_Practices" title="Advisory Committee on Immunization Practices">ACIP</a></li> <li><a href="/wiki/National_Vaccine_Injury_Compensation_Program" title="National Vaccine Injury Compensation Program">Vaccine court</a></li> <li><a href="/wiki/Vaccines_for_Children_Program" title="Vaccines for Children Program">Vaccines for Children Program</a></li> <li><a href="/wiki/Vaccine_Adverse_Event_Reporting_System" title="Vaccine Adverse Event Reporting System">VAERS</a></li> <li><a href="/wiki/Vaccine_Safety_Datalink" title="Vaccine Safety Datalink">VSD</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Vaccines</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Bacterial</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anthrax_vaccine" title="Anthrax vaccine">Anthrax</a></li> <li><a href="/wiki/Brucellosis_vaccine" title="Brucellosis vaccine">Brucellosis</a></li> <li><a href="/wiki/Cholera_vaccine" title="Cholera vaccine">Cholera</a>#</li> <li><a href="/wiki/Diphtheria_vaccine" title="Diphtheria vaccine">Diphtheria</a>#</li> <li><a href="/wiki/Hib_vaccine" title="Hib vaccine">Hib</a>#</li> <li><a href="/wiki/Leptospirosis#Prevention" title="Leptospirosis">Leptospirosis</a></li> <li><a href="/wiki/Lyme_disease#Vaccination" title="Lyme disease">Lyme disease</a>‡</li> <li><a href="/wiki/Meningococcal_vaccine" title="Meningococcal vaccine">Meningococcus</a># <ul><li><a href="/wiki/MeNZB" title="MeNZB">MeNZB</a></li> <li><a href="/wiki/NmVac4-A/C/Y/W-135" title="NmVac4-A/C/Y/W-135">NmVac4-A/C/Y/W-135</a></li></ul></li> <li><a href="/wiki/Pertussis_vaccine" title="Pertussis vaccine">Pertussis</a>#</li> <li><a href="/wiki/Plague_vaccine" title="Plague vaccine">Plague</a></li> <li><a href="/wiki/Pneumococcal_vaccine" title="Pneumococcal vaccine">Pneumococcal</a># <ul><li><a href="/wiki/Pneumococcal_conjugate_vaccine" title="Pneumococcal conjugate vaccine">PCV</a></li> <li><a href="/wiki/Pneumococcal_polysaccharide_vaccine" title="Pneumococcal polysaccharide vaccine">PPSV</a></li></ul></li> <li><a href="/wiki/Q_fever#Prevention" title="Q fever">Q fever</a></li> <li><a href="/wiki/Tetanus_vaccine" title="Tetanus vaccine">Tetanus</a>#</li> <li><a href="/wiki/Tuberculosis_vaccines" title="Tuberculosis vaccines">Tuberculosis</a> <ul><li><a href="/wiki/BCG_vaccine" title="BCG vaccine">BCG</a>#</li></ul></li> <li><a href="/wiki/Typhoid_vaccine" title="Typhoid vaccine">Typhoid</a># <ul><li><a href="/wiki/Ty21a" title="Ty21a">Ty21a</a></li> <li><a href="/wiki/Vi_capsular_polysaccharide_vaccine" title="Vi capsular polysaccharide vaccine">ViCPS</a></li></ul></li> <li><a href="/wiki/Typhus_vaccine" title="Typhus vaccine">Typhus</a></li> <li>combination: <ul><li><a href="/wiki/DPT_vaccine" title="DPT vaccine">DPT/DTwP/DTaP</a></li> <li><a href="/wiki/Tetanus_vaccine" title="Tetanus vaccine">Td/Tdap</a></li></ul></li> <li>research: <ul><li><a href="/wiki/Clostridioides_difficile_infection#Research" title="Clostridioides difficile infection">Clostridioides difficile</a></li> <li><a href="/wiki/Group_B_streptococcal_infection#Vaccine" title="Group B streptococcal infection">Group B streptococcal disease</a></li> <li><a href="/wiki/Shigellosis#Vaccine" title="Shigellosis">Shigellosis</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Viral</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Adenovirus_vaccine" title="Adenovirus vaccine">Adenovirus</a></li> <li><a href="/wiki/Chikungunya_vaccine" title="Chikungunya vaccine">Chikungunya</a></li> <li><a href="/wiki/Ebola_vaccine" title="Ebola vaccine">Ebola</a> <ul><li><a href="/wiki/RVSV-ZEBOV_vaccine" title="RVSV-ZEBOV vaccine">rVSV-ZEBOV</a></li></ul></li> <li><a href="/wiki/Influenza_vaccine" title="Influenza vaccine">Flu</a># <ul><li><a href="/wiki/2009_swine_flu_pandemic_vaccine" title="2009 swine flu pandemic vaccine">H1N1</a> (<a href="/wiki/Pandemrix" title="Pandemrix">Pandemrix</a>)</li> <li><a href="/wiki/H5N1_vaccine" title="H5N1 vaccine">H5N1</a></li> <li><a href="/wiki/H5N8_vaccine" title="H5N8 vaccine">H5N8</a></li> <li><a href="/wiki/Live_attenuated_influenza_vaccine" title="Live attenuated influenza vaccine">LAIV</a></li></ul></li> <li><a href="/wiki/Hantavirus_vaccine" title="Hantavirus vaccine">Hantavirus</a></li> <li><a href="/wiki/Hepatitis_A_vaccine" title="Hepatitis A vaccine">Hepatitis A</a>#</li> <li><a href="/wiki/Hepatitis_B_vaccine" title="Hepatitis B vaccine">Hepatitis B</a>#</li> <li><a href="/wiki/Hepatitis_E#Vaccines" title="Hepatitis E">Hepatitis E</a></li> <li><a href="/wiki/HPV_vaccine" title="HPV vaccine">HPV</a># <ul><li><a href="/wiki/Cervarix" title="Cervarix">Cervarix</a></li> <li><a href="/wiki/Gardasil" title="Gardasil">Gardasil</a></li></ul></li> <li><a href="/wiki/Japanese_encephalitis_vaccine" title="Japanese encephalitis vaccine">Japanese encephalitis</a>#</li> <li><a href="/wiki/Measles_vaccine" title="Measles vaccine">Measles</a>#</li> <li><a href="/wiki/Mpox_vaccine" class="mw-redirect" title="Mpox vaccine">Mpox</a></li> <li><a href="/wiki/Mumps_vaccine" title="Mumps vaccine">Mumps</a>#</li> <li><a href="/wiki/Polio_vaccine" title="Polio vaccine">Polio</a># <ul><li><a href="/wiki/Polio_vaccine#Attenuated" title="Polio vaccine">Sabin</a></li> <li><a href="/wiki/Polio_vaccine#Inactivated" title="Polio vaccine">Salk</a></li></ul></li> <li><a href="/wiki/Rabies_vaccine" title="Rabies vaccine">Rabies</a>#</li> <li><a href="/wiki/Rotavirus_vaccine" title="Rotavirus vaccine">Rotavirus</a>#</li> <li><a href="/wiki/Rubella_vaccine" title="Rubella vaccine">Rubella</a>#</li> <li><a href="/wiki/COVID-19_vaccine" title="COVID-19 vaccine">SARS-CoV-2</a> <ul><li><a href="/wiki/Corbevax" title="Corbevax">Corbevax</a>†</li> <li><a href="/wiki/Covaxin" title="Covaxin">Bharat Biotech</a>†</li> <li><a href="/wiki/Convidecia" title="Convidecia">CanSino</a>†</li> <li><a href="/wiki/CoronaVac" title="CoronaVac">CoronaVac</a>†</li> <li><a href="/wiki/EpiVacCorona" title="EpiVacCorona">EpiVacCorona</a>†</li> <li><a href="/wiki/Janssen_COVID-19_vaccine" title="Janssen COVID-19 vaccine">Janssen</a></li> <li><a href="/wiki/Moderna_COVID-19_vaccine" title="Moderna COVID-19 vaccine">Moderna</a></li> <li><a href="/wiki/Novavax_COVID-19_vaccine" title="Novavax COVID-19 vaccine">Novavax</a></li> <li><a href="/wiki/Oxford%E2%80%93AstraZeneca_COVID-19_vaccine" title="Oxford–AstraZeneca COVID-19 vaccine">Oxford–AstraZeneca</a></li> <li><a href="/wiki/Pfizer%E2%80%93BioNTech_COVID-19_vaccine" title="Pfizer–BioNTech COVID-19 vaccine">Pfizer–BioNTech</a></li> <li><a href="/wiki/Sanofi%E2%80%93GSK_COVID-19_vaccine" title="Sanofi–GSK COVID-19 vaccine">Sanofi–GSK</a>†</li> <li><a href="/wiki/Sinopharm_BIBP_COVID-19_vaccine" title="Sinopharm BIBP COVID-19 vaccine">Sinopharm BIBP</a>†</li> <li><a href="/wiki/Skycovione" title="Skycovione">Skycovione</a>†</li> <li><a href="/wiki/Sputnik_V_COVID-19_vaccine" title="Sputnik V COVID-19 vaccine">Sputnik V</a>†</li> <li><a href="/wiki/Valneva_COVID-19_vaccine" title="Valneva COVID-19 vaccine">Valneva</a>†</li></ul></li> <li><a href="/wiki/Respiratory_syncytial_virus_vaccine" title="Respiratory syncytial virus vaccine">Respiratory syncytial virus (RSV)</a></li> <li><a href="/wiki/Smallpox_vaccine" title="Smallpox vaccine">Smallpox</a></li> <li><a href="/wiki/Tick-borne_encephalitis_vaccine" title="Tick-borne encephalitis vaccine">Tick-borne encephalitis</a>#</li> <li>Varicella zoster <ul><li><a href="/wiki/Varicella_vaccine" title="Varicella vaccine">Chicken pox</a>#</li> <li><a href="/wiki/Zoster_vaccine" title="Zoster vaccine">Shingles</a></li></ul></li> <li><a href="/wiki/Yellow_fever_vaccine" title="Yellow fever vaccine">Yellow fever</a>#</li> <li>combination: <ul><li><a href="/wiki/Hepatitis_A_and_B_vaccine" title="Hepatitis A and B vaccine">Hepatitis A and B</a></li> <li><a href="/wiki/MMR_vaccine" title="MMR vaccine">MMR</a></li> <li><a href="/wiki/MMRV_vaccine" title="MMRV vaccine">MMRV</a></li></ul></li> <li>research: <ul><li><a href="/wiki/Cytomegalovirus_vaccine" title="Cytomegalovirus vaccine">Cytomegalovirus</a></li> <li><a href="/wiki/Dengue_vaccine" title="Dengue vaccine">Dengue</a>#</li> <li><a href="/wiki/Epstein%E2%80%93Barr_virus_vaccine" title="Epstein–Barr virus vaccine">Epstein–Barr virus</a></li> <li><a href="/wiki/Hepatitis_C_vaccine" title="Hepatitis C vaccine">Hepatitis C</a></li> <li><a href="/wiki/Herpes_simplex_research" title="Herpes simplex research">Herpes simplex</a></li> <li><a href="/wiki/HIV_vaccine_development" title="HIV vaccine development">HIV</a></li> <li><a href="/wiki/Zika_virus_vaccine" title="Zika virus vaccine">Zika</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Protozoan</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Malaria_vaccine" title="Malaria vaccine">Malaria</a> <ul><li><a href="/wiki/RTS,S" title="RTS,S">RTS,S</a></li></ul></li> <li>research: <ul><li><a href="/wiki/Trypanosomiasis_vaccine" title="Trypanosomiasis vaccine">Trypanosomiasis</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Helminthiasis" title="Helminthiasis">Helminthiasis</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>research: <ul><li><a href="/wiki/Hookworm_vaccine" title="Hookworm vaccine">Hookworm</a></li> <li><a href="/wiki/Schistosomiasis_vaccine" title="Schistosomiasis vaccine">Schistosomiasis</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Androvax" title="Androvax">Androvax (androstenedione albumin)</a></li> <li><a href="/wiki/Cancer_vaccine" title="Cancer vaccine">Cancer vaccines</a> <ul><li><a href="/wiki/ALVAC-CEA_vaccine" title="ALVAC-CEA vaccine">ALVAC-CEA</a></li> <li><a href="/wiki/BCG_vaccine" title="BCG vaccine">BCG</a>#</li> <li><a href="/wiki/Hepatitis_B_vaccine" title="Hepatitis B vaccine">Hepatitis B</a>#</li> <li><a href="/wiki/HPV_vaccine" title="HPV vaccine">HPV</a># <ul><li><a href="/wiki/Cervarix" title="Cervarix">Cervarix</a></li> <li><a href="/wiki/Gardasil" title="Gardasil">Gardasil</a></li></ul></li> <li><a href="/wiki/Prostvac" title="Prostvac">Prostvac</a></li></ul></li> <li><a href="/wiki/NicVAX" title="NicVAX">NicVAX</a></li> <li><a href="/wiki/Ovandrotone_albumin" title="Ovandrotone albumin">Ovandrotone albumin (Fecundin)</a></li> <li><a href="/wiki/TA-CD" title="TA-CD">TA-CD</a></li> <li><a href="/wiki/TA-NIC" title="TA-NIC">TA-NIC</a></li> <li>combination: <ul><li><a href="/wiki/DTaP-IPV/Hib_vaccine" title="DTaP-IPV/Hib vaccine">DTaP-IPV/Hib</a></li> <li><a href="/wiki/DTaP-IPV-HepB_vaccine" title="DTaP-IPV-HepB vaccine">DTaP-IPV-HepB</a></li> <li><a href="/wiki/DTwP-HepB-Hib_vaccine" title="DTwP-HepB-Hib vaccine">DTwP-HepB-Hib</a></li> <li><a href="/wiki/Hexavalent_vaccine" title="Hexavalent vaccine">Hexavalent vaccine</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Inventors/ researchers</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Edward_Jenner" title="Edward Jenner">Edward Jenner</a></li> <li><a href="/wiki/Louis_Pasteur" title="Louis Pasteur">Louis Pasteur</a></li> <li><a href="/wiki/Hilary_Koprowski" title="Hilary Koprowski">Hilary Koprowski</a></li> <li><a href="/wiki/Jonas_Salk" title="Jonas Salk">Jonas Salk</a></li> <li><a href="/wiki/John_Franklin_Enders" title="John Franklin Enders">John Franklin Enders</a></li> <li><a href="/wiki/Maurice_Hilleman" title="Maurice Hilleman">Maurice Hilleman</a></li> <li><a href="/wiki/Stanley_Plotkin" title="Stanley Plotkin">Stanley Plotkin</a></li> <li><a href="/wiki/H._Fred_Clark" title="H. Fred Clark">H. Fred Clark</a></li> <li><a href="/wiki/Paul_Offit" title="Paul Offit">Paul Offit</a></li> <li><a href="/wiki/Katalin_Karik%C3%B3" title="Katalin Karikó">Katalin Karikó</a></li> <li><a href="/wiki/Drew_Weissman" title="Drew Weissman">Drew Weissman</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Controversy</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Vaccine_hesitancy" title="Vaccine hesitancy">General</a></li> <li><a href="/wiki/MMR_vaccine_and_autism" title="MMR vaccine and autism">MMR</a> (<a href="/wiki/Lancet_MMR_autism_fraud" title="Lancet MMR autism fraud">Lancet MMR autism fraud</a>)</li> <li><a href="/wiki/National_Childhood_Vaccine_Injury_Act" title="National Childhood Vaccine Injury Act">NCVIA</a></li> <li><a href="/wiki/Pox_party" title="Pox party">Pox party</a></li> <li><a href="/wiki/Thiomersal_and_vaccines" title="Thiomersal and vaccines">Thiomersal</a></li> <li><a href="/wiki/Vaccines_and_SIDS" title="Vaccines and SIDS">Vaccines and SIDS</a></li> <li><a href="/wiki/Cedillo_v._Secretary_of_Health_and_Human_Services" title="Cedillo v. Secretary of Health and Human Services">Cedillo v. Secretary of Health and Human Services</a></li> <li><a href="/wiki/Alternative_vaccination_schedule" title="Alternative vaccination schedule">Alternative vaccination schedule</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Related</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Epidemiology" title="Epidemiology">Epidemiology</a></li> <li><a href="/wiki/Eradication_of_infectious_diseases" title="Eradication of infectious diseases">Eradication of infectious diseases</a></li> <li><a href="/wiki/Vaccinate_Your_Family" title="Vaccinate Your Family">Vaccinate Your Family</a></li> <li><a href="/wiki/List_of_vaccine_topics" title="List of vaccine topics">List of vaccine topics</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background: transparent; padding: 0px;"><div><div class="hlist"> <ul><li>#<a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">WHO-EM</a></li> <li>‡<a class="mw-selflink selflink">Withdrawn</a> from market</li> <li><a href="/wiki/Clinical_trial" title="Clinical trial">Clinical trials</a>: <ul><li>†<a href="/wiki/Phases_of_clinical_research#Phase_III" title="Phases of clinical research">Phase III</a></li> <li>§Never to phase III</li></ul></li></ul> </div></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=List_of_withdrawn_drugs&oldid=1250305465">https://en.wikipedia.org/w/index.php?title=List_of_withdrawn_drugs&oldid=1250305465</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:Withdrawn_drugs" title="Category:Withdrawn drugs">Withdrawn drugs</a></li><li><a href="/wiki/Category:Drug-related_lists" title="Category:Drug-related lists">Drug-related lists</a></li><li><a href="/wiki/Category:Medicine_timelines" title="Category:Medicine timelines">Medicine timelines</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Hidden categories: <ul><li><a href="/wiki/Category:CS1_maint:_multiple_names:_authors_list" title="Category:CS1 maint: multiple names: authors list">CS1 maint: multiple names: authors list</a></li><li><a href="/wiki/Category:Webarchive_template_other_archives" title="Category:Webarchive template other archives">Webarchive template other archives</a></li><li><a href="/wiki/Category:Webarchive_template_wayback_links" title="Category:Webarchive template wayback links">Webarchive template wayback links</a></li><li><a href="/wiki/Category:Articles_with_German-language_sources_(de)" title="Category:Articles with German-language sources (de)">Articles with German-language sources (de)</a></li><li><a href="/wiki/Category:Articles_with_short_description" title="Category:Articles with short description">Articles with short description</a></li><li><a href="/wiki/Category:Short_description_is_different_from_Wikidata" title="Category:Short description is different from Wikidata">Short description is different from Wikidata</a></li><li><a href="/wiki/Category:Incomplete_lists_from_July_2015" title="Category:Incomplete lists from July 2015">Incomplete lists from July 2015</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> This page was last edited on 9 October 2024, at 16:52 (UTC).</li> <li id="footer-info-copyright">Text is available under the <a href="/wiki/Wikipedia:Text_of_the_Creative_Commons_Attribution-ShareAlike_4.0_International_License" title="Wikipedia:Text of the Creative Commons Attribution-ShareAlike 4.0 International License">Creative Commons Attribution-ShareAlike 4.0 License</a>; additional terms may apply. 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