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margin-top:0; width:350px;" summary="Infobox Protein"> <tbody><tr> <th colspan="3" style="background:#90EE90; color:#202122;">Cytochrom P450 2C19 </th></tr> <tr style="text-align:center;"> <td colspan="3"><span typeof="mw:File"><a href="/wiki/Datei:Protein_CYP2C19_PDB_1r9o.png" class="mw-file-description" title="Cytochrom P450 2C19"><img alt="Cytochrom P450 2C19" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/11/Protein_CYP2C19_PDB_1r9o.png/250px-Protein_CYP2C19_PDB_1r9o.png" decoding="async" width="250" height="215" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/11/Protein_CYP2C19_PDB_1r9o.png/375px-Protein_CYP2C19_PDB_1r9o.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/11/Protein_CYP2C19_PDB_1r9o.png/500px-Protein_CYP2C19_PDB_1r9o.png 2x" data-file-width="907" data-file-height="780" /></a></span> </td></tr> <tr> <td colspan="3" class="hintergrundfarbe1" style="font-size:smaller;"> <p>Vorhandene Strukturdaten: <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4GQS">4GQS</a> </p> </td></tr> <tr> <th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner </th></tr> <tr> <td>Externe IDs </td> <td colspan="2" class="plainlinks"> <ul><li><a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=CYP2C19">CYP2C19</a></li> <li><a href="/wiki/UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P33261">P33261</a></li></ul> </td></tr> <tr> <th colspan="3" style="background:#90EE90; color:#202122;">Enzymklassifikation </th></tr> <tr> <td><a href="/wiki/EC-Nummer" title="EC-Nummer">EC, Kategorie</a> </td> <td colspan="2" class="plainlinks" style="text-align:center;"><a rel="nofollow" class="external text" href="https://www.brenda-enzymes.org/enzyme.php?ecno=1.14.14.51">1.14.14.51</a> </td></tr> <tr> <th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen </th></tr> <tr> <td style="background:#C3FDB8; color:#202122;">Homologie-Familie </td> <td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=P33261">Hovergen</a> </td></tr> </tbody></table><p><span class="editoronly" style="display:none;"></span> </p><p><b>Cytochrom P450 2C19</b> (abgekürzt <i>CYP2C19</i>) ist ein <a href="/wiki/Enzym" title="Enzym">Enzym</a>. Es ist ein Mitglied der CYP2C-Unterfamilie des <a href="/wiki/Cytochrom_P450" title="Cytochrom P450">Cytochrom P450</a>-Mischfunktions-<a href="/wiki/Oxidoreduktasen" title="Oxidoreduktasen">Oxidase</a>-Systems. Zu dieser Unterfamilie gehören Enzyme, die den <a href="/wiki/Stoffwechsel" title="Stoffwechsel">Metabolismus</a> von <a href="/wiki/Xenobiotikum" title="Xenobiotikum">Xenobiotika</a> <a href="/wiki/Katalyse" title="Katalyse">katalysieren</a>, darunter einige <a href="/wiki/Protonenpumpenhemmer" title="Protonenpumpenhemmer">Protonenpumpenhemmer</a> und <a href="/wiki/Antiepileptika" class="mw-redirect" title="Antiepileptika">Antiepileptika</a>. Beim <a href="/wiki/Mensch" title="Mensch">Menschen</a> ist es das CYP2C19-Gen, das für das CYP2C19-Protein kodiert.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> CYP2C19 ist ein <a href="/wiki/Leberenzyme" title="Leberenzyme">Leberenzym</a>, das auf mindestens 10 % der derzeit klinisch verwendeten Medikamente wirkt,<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> insbesondere auf das <a href="/wiki/Thrombozytenaggregationshemmer" title="Thrombozytenaggregationshemmer">Thrombozytenaggregationshemmer</a> <a href="/wiki/Clopidogrel" title="Clopidogrel">Clopidogrel</a> (<i>Plavix</i>), <a href="/wiki/Analgetikum" title="Analgetikum">Analgetika</a> für <a href="/wiki/Schmerz" title="Schmerz">Schmerzen</a> im Zusammenhang mit <a href="/wiki/Geschw%C3%BCr" class="mw-redirect" title="Geschwür">Geschwüren</a>, wie <a href="/wiki/Omeprazol" title="Omeprazol">Omeprazol</a>, Antiepileptika wie <a href="/w/index.php?title=Mephenytoin&action=edit&redlink=1" class="new" title="Mephenytoin (Seite nicht vorhanden)">Mephenytoin</a>, das <a href="/wiki/Malaria" title="Malaria">Antimalariamittel</a> <a href="/wiki/Proguanil" title="Proguanil">Proguanil</a> und das <a href="/wiki/Anxiolytikum" title="Anxiolytikum">Anxiolytikum</a> <a href="/wiki/Diazepam" title="Diazepam">Diazepam</a>.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p><p>CYP2C19 wurde in UniProt als (R)-Limonen-6-Monooxygenase und (S)-Limonen-6-Monooxygenase annotiert. </p> <div class="mw-heading mw-heading2"><h2 id="Funktion">Funktion</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Cytochrom_P450_2C19&veaction=edit&section=1" title="Abschnitt bearbeiten: Funktion" class="mw-editsection-visualeditor"><span>Bearbeiten</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Cytochrom_P450_2C19&action=edit&section=1" title="Quellcode des Abschnitts bearbeiten: Funktion"><span>Quelltext bearbeiten</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Das Gen kodiert ein Mitglied der <a href="/wiki/Cytochrom_P450" title="Cytochrom P450">Cytochrom-P450</a>-Familie von Enzymen. Enzyme der CYP2C-Subfamilie, einschließlich CYP2C19, machen etwa 20 % des Cytochrom P450 in der erwachsenen <a href="/wiki/Leber" title="Leber">Leber</a> aus.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> Diese Proteine sind <a href="/wiki/Monooxygenasen" class="mw-redirect" title="Monooxygenasen">Monooxygenasen</a>, die viele Reaktionen katalysieren, die am Arzneimittelstoffwechsel und der Synthese von <a href="/wiki/Cholesterin" title="Cholesterin">Cholesterin</a>, <a href="/wiki/Steroide" title="Steroide">Steroiden</a> und anderen <a href="/wiki/Lipide" title="Lipide">Lipiden</a> beteiligt sind. Dieses Protein lokalisiert sich im <a href="/wiki/Endoplasmatisches_Retikulum" title="Endoplasmatisches Retikulum">endoplasmatischen Retikulum</a> und ist dafür bekannt, viele Medikamente zu metabolisieren. <a href="/wiki/Polymorphismus" title="Polymorphismus">Polymorphismus</a> innerhalb dieses Gens ist mit einer variablen Fähigkeit, Medikamente zu metabolisieren, verbunden. Das Gen befindet sich innerhalb eines Clusters von Cytochrom-P450-Genen auf <a href="/wiki/Chromosom_10_(Mensch)" title="Chromosom 10 (Mensch)">Chromosom 10</a> Arm q24.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>CYP2C19 besitzt auch <a href="/w/index.php?title=Epoxygenasen&action=edit&redlink=1" class="new" title="Epoxygenasen (Seite nicht vorhanden)">Epoxygenase</a>-Aktivität: Es ist eines der wichtigsten Enzyme, das für den Angriff verschiedener langkettiger, <a href="/wiki/Mehrfach_unges%C3%A4ttigte_Fetts%C3%A4uren" class="mw-redirect" title="Mehrfach ungesättigte Fettsäuren">mehrfach ungesättigter Fettsäuren</a> an ihren <a href="/wiki/Doppelbindung" title="Doppelbindung">Doppelbindungen</a> (d. h. <a href="/wiki/Alkene" title="Alkene">Alken</a>) verantwortlich ist, um <a href="/wiki/Epoxide" title="Epoxide">Epoxidprodukte</a> zu bilden, die als <a href="/wiki/Botenstoff" title="Botenstoff">Signalstoffe</a> wirken. Es metabolisiert: </p> <ul><li><a href="/wiki/Arachidons%C3%A4ure" title="Arachidonsäure">Arachidonsäure</a> zu verschiedenen <a href="/w/index.php?title=Epoxyeicosatriens%C3%A4uren&action=edit&redlink=1" class="new" title="Epoxyeicosatriensäuren (Seite nicht vorhanden)">Epoxyeicosatriensäuren</a> (auch als EETs bezeichnet);</li> <li><a href="/wiki/Linols%C3%A4ure" title="Linolsäure">Linolsäure</a> zu 9,10-Epoxy-Octadecaensäuren (auch als <a href="/wiki/Vernols%C3%A4ure" title="Vernolsäure">Vernolsäure</a>, Linolsäure-9:10-Oxid oder Leukotoxin bezeichnet) und 12,13-Epoxy-Octadecaensäure (auch als Coronarsäure, Linolsäure-12,13-Oxid oder Isoleukotoxin bezeichnet);</li> <li><a href="/wiki/Docosahexaens%C3%A4ure" title="Docosahexaensäure">Docosahexaensäure</a> zu verschiedenen <a href="/w/index.php?title=Epoxydocosapentaens%C3%A4ure&action=edit&redlink=1" class="new" title="Epoxydocosapentaensäure (Seite nicht vorhanden)">Epoxydocosapentaensäuren</a> (auch als EDPs bezeichnet); und</li> <li><a href="/wiki/Eicosapentaens%C3%A4ure" title="Eicosapentaensäure">Eicosapentaensäure</a> zu verschiedenen <a href="/w/index.php?title=Epoxyeicosatetraens%C3%A4uren&action=edit&redlink=1" class="new" title="Epoxyeicosatetraensäuren (Seite nicht vorhanden)">Epoxyeicosatetraensäuren</a> (auch EEQs genannt).<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li>Neben CYP2C19 sind <a href="/wiki/CYP2C9" class="mw-redirect" title="CYP2C9">CYP2C8</a>, <a href="/wiki/CYP2C9" class="mw-redirect" title="CYP2C9">CYP2C9</a>, <a href="/w/index.php?title=CYP2J2&action=edit&redlink=1" class="new" title="CYP2J2 (Seite nicht vorhanden)">CYP2J2</a> und möglicherweise <a href="/w/index.php?title=CYP2S1&action=edit&redlink=1" class="new" title="CYP2S1 (Seite nicht vorhanden)">CYP2S1</a> die Hauptproduzenten von EETs und sehr wahrscheinlich EEQs, EDPs und den <a href="/wiki/Epoxide" title="Epoxide">Epoxiden</a> der Linolsäure.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup></li></ul> <div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Cytochrom_P450_2C19&veaction=edit&section=2" title="Abschnitt bearbeiten: Einzelnachweise" class="mw-editsection-visualeditor"><span>Bearbeiten</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Cytochrom_P450_2C19&action=edit&section=2" title="Quellcode des Abschnitts bearbeiten: Einzelnachweise"><span>Quelltext bearbeiten</span></a><span class="mw-editsection-bracket">]</span></span></div> <ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text">I. C. Gray, C. Nobile, R. Muresu, S. Ford, N. K. Spurr: <cite style="font-style:italic">A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24</cite>. In: <cite style="font-style:italic">Genomics</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>28</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>2</span>, 20. Juli 1995, <a href="/wiki/Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%220888-7543%22&key=cql">0888-7543</a></span>, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>328–332</span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1006/geno.1995.1149">10.1006/geno.1995.1149</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/8530044?dopt=Abstract">PMID 8530044</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Cytochrom+P450+2C19&rft.atitle=A+2.4-megabase+physical+map+spanning+the+CYP2C+gene+cluster+on+chromosome+10q24&rft.au=I.+C.+Gray%2C+C.+Nobile%2C+R.+Muresu%2C+...&rft.date=1995-07-20&rft.doi=10.1006%2Fgeno.1995.1149&rft.genre=journal&rft.issn=0888-7543&rft.issue=2&rft.jtitle=Genomics&rft.pages=328-332&rft.pmid=8530044&rft.volume=28" style="display:none"> </span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text">M. Romkes, M. B. Faletto, J. A. Blaisdell, J. L. Raucy, J. A. Goldstein: <cite style="font-style:italic">Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily</cite>. In: <cite style="font-style:italic">Biochemistry</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>30</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>13</span>, 2. April 1991, <a href="/wiki/Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%220006-2960%22&key=cql">0006-2960</a></span>, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>3247–3255</span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1021/bi00227a012">10.1021/bi00227a012</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/2009263?dopt=Abstract">PMID 2009263</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Cytochrom+P450+2C19&rft.atitle=Cloning+and+expression+of+complementary+DNAs+for+multiple+members+of+the+human+cytochrome+P450IIC+subfamily&rft.au=M.+Romkes%2C+M.+B.+Faletto%2C+J.+A.+Blaisdell%2C+...&rft.date=1991-04-02&rft.doi=10.1021%2Fbi00227a012&rft.genre=journal&rft.issn=0006-2960&rft.issue=13&rft.jtitle=Biochemistry&rft.pages=3247-3255&rft.pmid=2009263&rft.volume=30" style="display:none"> </span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text"><span class="cite"><a rel="nofollow" class="external text" href="https://medlineplus.gov/genetics/gene/cyp2c19/"><i>CYP2C19 gene: MedlinePlus Genetics.</i></a><span class="Abrufdatum"> Abgerufen am 5. März 2021</span> (englisch).</span><span style="display: none;" class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2Fde.wikipedia.org%3ACytochrom+P450+2C19&rft.title=CYP2C19+gene%3A+MedlinePlus+Genetics&rft.description=CYP2C19+gene%3A+MedlinePlus+Genetics&rft.identifier=https%3A%2F%2Fmedlineplus.gov%2Fgenetics%2Fgene%2Fcyp2c19%2F&rft.language=en"> </span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text"><span class="cite"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20160415033812/http://www.mayomedicallaboratories.com/articles/features/cyp2c19/index.html"><i>Cytochrome P450 2C19 (CYP2C19) Genotype – Mayo Medical Laboratories.</i></a> 15. April 2016, archiviert vom <style data-mw-deduplicate="TemplateStyles:r235239667">.mw-parser-output .dewiki-iconexternal>a{background-position:center right;background-repeat:no-repeat}body.skin-minerva .mw-parser-output .dewiki-iconexternal>a{background-image:url("https://upload.wikimedia.org/wikipedia/commons/a/a4/OOjs_UI_icon_external-link-ltr-progressive.svg")!important;background-size:10px;padding-right:13px!important}body.skin-timeless .mw-parser-output .dewiki-iconexternal>a,body.skin-monobook .mw-parser-output .dewiki-iconexternal>a{background-image:url("https://upload.wikimedia.org/wikipedia/commons/3/30/MediaWiki_external_link_icon.svg")!important;padding-right:13px!important}body.skin-vector .mw-parser-output .dewiki-iconexternal>a{background-image:url("https://upload.wikimedia.org/wikipedia/commons/9/96/Link-external-small-ltr-progressive.svg")!important;background-size:0.857em;padding-right:1em!important}</style><span class="dewiki-iconexternal"><a class="external text" href="https://redirecter.toolforge.org/?url=http%3A%2F%2Fwww.mayomedicallaboratories.com%2Farticles%2Ffeatures%2Fcyp2c19%2Findex.html">Original</a></span> am <span style="white-space:nowrap;">15. April 2016</span><span>;</span><span class="Abrufdatum"> abgerufen am 5. März 2021</span>.</span><span style="display: none;" class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2Fde.wikipedia.org%3ACytochrom+P450+2C19&rft.title=Cytochrome+P450+2C19+%28CYP2C19%29+Genotype+%E2%80%93+Mayo+Medical+Laboratories&rft.description=Cytochrome+P450+2C19+%28CYP2C19%29+Genotype+%E2%80%93+Mayo+Medical+Laboratories&rft.identifier=https%3A%2F%2Fweb.archive.org%2Fweb%2F20160415033812%2Fhttp%3A%2F%2Fwww.mayomedicallaboratories.com%2Farticles%2Ffeatures%2Fcyp2c19%2Findex.html&rft.date=2016-04-15&rft.source=http://www.mayomedicallaboratories.com/articles/features/cyp2c19/index.html"> </span></span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><a href="#cite_ref-5">↑</a></span> <span class="reference-text">S. B. Koukouritaki, J. Manro, Sandra A. Marsh, J. C. Stevens, A. Rettie: <cite style="font-style:italic">Developmental Expression of Human Hepatic CYP2C9 and CYP2C19</cite>. In: <cite style="font-style:italic">Journal of Pharmacology and Experimental Therapeutics</cite>. 2004, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1124/JPET.103.060137">10.1124/JPET.103.060137</a></span> (<a rel="nofollow" class="external text" href="https://www.semanticscholar.org/paper/Developmental-Expression-of-Human-Hepatic-CYP2C9-Koukouritaki-Manro/cab6e62fb76c87c08ab418c92a8935882a278155">semanticscholar.org</a> [abgerufen am 5. März 2021]).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rfr_id=info:sid/de.wikipedia.org:Cytochrom+P450+2C19&rft.atitle=Developmental+Expression+of+Human+Hepatic+CYP2C9+and+CYP2C19&rft.au=S.+B.+Koukouritaki%2C+J.+Manro%2C+Sandra+A.+Marsh%2C+...&rft.btitle=Journal+of+Pharmacology+and+Experimental+Therapeutics&rft.date=2004&rft.doi=10.1124%2FJPET.103.060137&rft.genre=book" style="display:none"> </span></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><a href="#cite_ref-6">↑</a></span> <span class="reference-text"><span class="cite"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene/1557"><i>CYP2C19 cytochrome P450 family 2 subfamily C member 19 [Homo sapiens (human)] – Gene – NCBI.</i></a><span class="Abrufdatum"> Abgerufen am 5. März 2021</span>.</span><span style="display: none;" class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2Fde.wikipedia.org%3ACytochrom+P450+2C19&rft.title=CYP2C19+cytochrome+P450+family+2+subfamily+C+member+19+%26%23091%3BHomo+sapiens+%28human%29%26%23093%3B+%E2%80%93+Gene+%E2%80%93+NCBI&rft.description=CYP2C19+cytochrome+P450+family+2+subfamily+C+member+19+%26%23091%3BHomo+sapiens+%28human%29%26%23093%3B+%E2%80%93+Gene+%E2%80%93+NCBI&rft.identifier=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgene%2F1557"> </span></span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><a href="#cite_ref-7">↑</a></span> <span class="reference-text">Ingrid Fleming: <cite style="font-style:italic">The Pharmacology of the Cytochrome P450 Epoxygenase/Soluble Epoxide Hydrolase Axis in the Vasculature and Cardiovascular Disease</cite>. In: <cite style="font-style:italic">Pharmacological Reviews</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>66</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>4</span>, 1. Oktober 2014, <a href="/wiki/Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%220031-6997%22&key=cql">0031-6997</a></span>, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>1106–1140</span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1124/pr.113.007781">10.1124/pr.113.007781</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/25244930?dopt=Abstract">PMID 25244930</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Cytochrom+P450+2C19&rft.atitle=The+Pharmacology+of+the+Cytochrome+P450+Epoxygenase%2FSoluble+Epoxide+Hydrolase+Axis+in+the+Vasculature+and+Cardiovascular+Disease&rft.au=Ingrid+Fleming&rft.date=2014-10-01&rft.doi=10.1124%2Fpr.113.007781&rft.genre=journal&rft.issn=0031-6997&rft.issue=4&rft.jtitle=Pharmacological+Reviews&rft.pages=1106-1140&rft.pmid=25244930&rft.volume=66" style="display:none"> </span></span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><a href="#cite_ref-8">↑</a></span> <span class="reference-text">Karen Wagner, Steve Vito, Bora Inceoglu, Bruce D. Hammock: <cite style="font-style:italic">The Role of Long Chain Fatty Acids and Their Epoxide Metabolites in Nociceptive Signaling</cite>. In: <cite style="font-style:italic">Prostaglandins & other lipid mediators</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>0</span>, Oktober 2014, <a href="/wiki/Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221098-8823%22&key=cql">1098-8823</a></span>, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>2–12</span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.prostaglandins.2014.09.001">10.1016/j.prostaglandins.2014.09.001</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/25240260?dopt=Abstract">PMID 25240260</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254344/">PMC 4254344</a> (freier Volltext).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Cytochrom+P450+2C19&rft.atitle=The+Role+of+Long+Chain+Fatty+Acids+and+Their+Epoxide+Metabolites+in+Nociceptive+Signaling&rft.au=Karen+Wagner%2C+Steve+Vito%2C+Bora+Inceoglu%2C+...&rft.date=2014-10&rft.doi=10.1016%2Fj.prostaglandins.2014.09.001&rft.genre=journal&rft.issn=1098-8823&rft.jtitle=Prostaglandins+%26+other+lipid+mediators&rft.pages=2-12&rft.pmc=4254344&rft.pmid=25240260&rft.volume=0" style="display:none"> </span></span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><a href="#cite_ref-9">↑</a></span> <span class="reference-text">Robert Fischer, Anne Konkel, Heidrun Mehling, Katrin Blossey, Andrej Gapelyuk: <cite style="font-style:italic">Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway</cite>. In: <cite style="font-style:italic">Journal of Lipid Research</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>55</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>6</span>, Juni 2014, <a href="/wiki/Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%220022-2275%22&key=cql">0022-2275</a></span>, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>1150–1164</span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1194/jlr.M047357">10.1194/jlr.M047357</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/24634501?dopt=Abstract">PMID 24634501</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031946/">PMC 4031946</a> (freier Volltext).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Cytochrom+P450+2C19&rft.atitle=Dietary+omega-3+fatty+acids+modulate+the+eicosanoid+profile+in+man+primarily+via+the+CYP-epoxygenase+pathway&rft.au=Robert+Fischer%2C+Anne+Konkel%2C+Heidrun+Mehling%2C+...&rft.date=2014-06&rft.doi=10.1194%2Fjlr.M047357&rft.genre=journal&rft.issn=0022-2275&rft.issue=6&rft.jtitle=Journal+of+Lipid+Research&rft.pages=1150-1164&rft.pmc=4031946&rft.pmid=24634501&rft.volume=55" style="display:none"> </span></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><a href="#cite_ref-10">↑</a></span> <span class="reference-text">Karen Wagner, Steve Vito, Bora Inceoglu, Bruce D. Hammock: <cite style="font-style:italic">The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling</cite>. In: <cite style="font-style:italic">Prostaglandins & Other Lipid Mediators</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>113–115</span>, Oktober 2014, <a href="/wiki/Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%221098-8823%22&key=cql">1098-8823</a></span>, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>2–12</span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.prostaglandins.2014.09.001">10.1016/j.prostaglandins.2014.09.001</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/25240260?dopt=Abstract">PMID 25240260</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254344/">PMC 4254344</a> (freier Volltext).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Cytochrom+P450+2C19&rft.atitle=The+role+of+long+chain+fatty+acids+and+their+epoxide+metabolites+in+nociceptive+signaling&rft.au=Karen+Wagner%2C+Steve+Vito%2C+Bora+Inceoglu%2C+...&rft.date=2014-10&rft.doi=10.1016%2Fj.prostaglandins.2014.09.001&rft.genre=journal&rft.issn=1098-8823&rft.jtitle=Prostaglandins+%26+Other+Lipid+Mediators&rft.pages=2-12&rft.pmc=4254344&rft.pmid=25240260&rft.volume=113-115" style="display:none"> </span></span> </li> <li id="cite_note-11"><span class="mw-cite-backlink"><a href="#cite_ref-11">↑</a></span> <span class="reference-text">Arthur A. Spector, Hee-Yong Kim: <cite style="font-style:italic">Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism</cite>. In: <cite style="font-style:italic">Biochimica Et Biophysica Acta</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>1851</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>4</span>, April 2015, <a href="/wiki/Internationale_Standardnummer_f%C3%BCr_fortlaufende_Sammelwerke" title="Internationale Standardnummer für fortlaufende Sammelwerke">ISSN</a> <span style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://zdb-katalog.de/list.xhtml?t=iss%3D%220006-3002%22&key=cql">0006-3002</a></span>, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>356–365</span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.bbalip.2014.07.020">10.1016/j.bbalip.2014.07.020</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/25093613?dopt=Abstract">PMID 25093613</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314516/">PMC 4314516</a> (freier Volltext).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Cytochrom+P450+2C19&rft.atitle=Cytochrome+P450+epoxygenase+pathway+of+polyunsaturated+fatty+acid+metabolism&rft.au=Arthur+A.+Spector%2C+Hee-Yong+Kim&rft.date=2015-04&rft.doi=10.1016%2Fj.bbalip.2014.07.020&rft.genre=journal&rft.issn=0006-3002&rft.issue=4&rft.jtitle=Biochimica+Et+Biophysica+Acta&rft.pages=356-365&rft.pmc=4314516&rft.pmid=25093613&rft.volume=1851" style="display:none"> </span></span> </li> </ol></div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Abgerufen von „<a dir="ltr" href="https://de.wikipedia.org/w/index.php?title=Cytochrom_P450_2C19&oldid=244953646">https://de.wikipedia.org/w/index.php?title=Cytochrom_P450_2C19&oldid=244953646</a>“</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Wikipedia:Kategorien" title="Wikipedia:Kategorien">Kategorien</a>: <ul><li><a href="/wiki/Kategorie:Codiert_auf_Chromosom_10_(Mensch)" title="Kategorie:Codiert auf Chromosom 10 (Mensch)">Codiert auf Chromosom 10 (Mensch)</a></li><li><a href="/wiki/Kategorie:Cytochrom_P450" title="Kategorie:Cytochrom P450">Cytochrom P450</a></li></ul></div></div> </div> </div> <div id="mw-navigation"> <h2>Navigationsmenü</h2> <div id="mw-head"> <nav id="p-personal" class="mw-portlet mw-portlet-personal vector-user-menu-legacy vector-menu" aria-labelledby="p-personal-label" > <h3 id="p-personal-label" class="vector-menu-heading " > <span class="vector-menu-heading-label">Meine Werkzeuge</span> </h3> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anonuserpage" class="mw-list-item"><span title="Benutzerseite der IP-Adresse, von der aus du Änderungen durchführst">Nicht angemeldet</span></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Spezial:Meine_Diskussionsseite" title="Diskussion über Änderungen von dieser IP-Adresse [n]" accesskey="n"><span>Diskussionsseite</span></a></li><li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Spezial:Meine_Beitr%C3%A4ge" title="Eine Liste der Bearbeitungen, die von dieser IP-Adresse gemacht wurden [y]" accesskey="y"><span>Beiträge</span></a></li><li id="pt-createaccount" class="mw-list-item"><a href="/w/index.php?title=Spezial:Benutzerkonto_anlegen&returnto=Cytochrom+P450+2C19" title="Wir ermutigen dich dazu, ein Benutzerkonto zu erstellen und dich anzumelden. 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