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overflow: hidden; text-overflow: ellipsis; -webkit-line-clamp: 3; -webkit-box-orient: vertical; }</style><div class="col-xs-12 clearfix"><div class="u-floatLeft"><h1 class="PageHeader-title u-m0x u-fs30">Apoptose</h1><div class="u-tcGrayDark">17 Followers</div><div class="u-tcGrayDark u-mt2x">Recent papers in <b>Apoptose</b></div></div></div></div></div></div><div class="TabbedNavigation"><div class="container"><div class="row"><div class="col-xs-12 clearfix"><ul class="nav u-m0x u-p0x list-inline u-displayFlex"><li class="active"><a href="https://www.academia.edu/Documents/in/Apoptose">Top Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Apoptose/MostCited">Most Cited Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Apoptose/MostDownloaded">Most Downloaded Papers</a></li><li><a href="https://www.academia.edu/Documents/in/Apoptose/MostRecent">Newest Papers</a></li><li><a class="" href="https://www.academia.edu/People/Apoptose">People</a></li></ul></div><style type="text/css">ul.nav{flex-direction:row}@media(max-width: 567px){ul.nav{flex-direction:column}.TabbedNavigation li{max-width:100%}.TabbedNavigation li.active{background-color:var(--background-grey, #dddde2)}.TabbedNavigation li.active:before,.TabbedNavigation li.active:after{display:none}}</style></div></div></div><div class="container"><div class="row"><div class="col-xs-12"><div class="u-displayFlex"><div class="u-flexGrow1"><div class="works"><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_45077444" data-work_id="45077444" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/45077444/Castration_resistant_Prostate_Cancer_From_New_Pathophysiology_to_New_Treatment_Targets">Castration-resistant Prostate Cancer: From New Pathophysiology to New Treatment Targets</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">ContextCastration-resistant prostate cancer (CRPC) refers to patients who no longer respond to surgical or medical castration. 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Standard treatment options are limited.","downloadable_attachments":[{"id":65635309,"asset_id":45077444,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":185020643,"first_name":"Bertrand","last_name":"TOMBAL","domain_name":"uclep","page_name":"BertrandTOMBAL","display_name":"Bertrand TOMBAL","profile_url":"https://uclep.academia.edu/BertrandTOMBAL?f_ri=288801","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":622,"name":"Nephrology","url":"https://www.academia.edu/Documents/in/Nephrology?f_ri=288801","nofollow":false},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=288801","nofollow":false},{"id":12980,"name":"Prostate Cancer","url":"https://www.academia.edu/Documents/in/Prostate_Cancer?f_ri=288801","nofollow":false},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=288801","nofollow":false},{"id":39001,"name":"Pathophysiology","url":"https://www.academia.edu/Documents/in/Pathophysiology?f_ri=288801"},{"id":48981,"name":"Molecular chaperones","url":"https://www.academia.edu/Documents/in/Molecular_chaperones?f_ri=288801"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=288801"},{"id":96098,"name":"Resistance","url":"https://www.academia.edu/Documents/in/Resistance?f_ri=288801"},{"id":111545,"name":"Male","url":"https://www.academia.edu/Documents/in/Male?f_ri=288801"},{"id":112576,"name":"Cell Death","url":"https://www.academia.edu/Documents/in/Cell_Death?f_ri=288801"},{"id":126863,"name":"Immunotherapy","url":"https://www.academia.edu/Documents/in/Immunotherapy?f_ri=288801"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=288801"},{"id":288801,"name":"Apoptose","url":"https://www.academia.edu/Documents/in/Apoptose?f_ri=288801"},{"id":590252,"name":"Androgen Receptor","url":"https://www.academia.edu/Documents/in/Androgen_Receptor?f_ri=288801"},{"id":1639402,"name":"nuclear factor kappa B","url":"https://www.academia.edu/Documents/in/nuclear_factor_kappa_B?f_ri=288801"},{"id":1750086,"name":"Insulin Like Growth Factor","url":"https://www.academia.edu/Documents/in/Insulin_Like_Growth_Factor?f_ri=288801"},{"id":1810430,"name":"Chaperone","url":"https://www.academia.edu/Documents/in/Chaperone?f_ri=288801"},{"id":1953384,"name":"Activator","url":"https://www.academia.edu/Documents/in/Activator?f_ri=288801"},{"id":3205111,"name":"Prostatic neoplasms","url":"https://www.academia.edu/Documents/in/Prostatic_neoplasms?f_ri=288801"},{"id":3752792,"name":"orchiectomy","url":"https://www.academia.edu/Documents/in/orchiectomy?f_ri=288801"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_64862237" data-work_id="64862237" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/64862237/R%C3%B4le_de_la_prot%C3%A9ine_LMP1_dans_la_balance_survie_apoptose_des_cellules_infect%C3%A9es_par_le_virus_d_Epstein_Barr">Rôle de la protéine LMP1 dans la balance survie/apoptose des cellules infectées par le virus d’Epstein-Barr</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Le virus d’Epstein-Barr (EBV) est un herpesvirus humain qui infecte 90% de la population, mais l’infection est, le plus souvent, asymptomatique. Apres infection, le virus etablit une latence virale caracterisee par l’expression restreinte... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_64862237" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Le virus d’Epstein-Barr (EBV) est un herpesvirus humain qui infecte 90% de la population, mais l’infection est, le plus souvent, asymptomatique. Apres infection, le virus etablit une latence virale caracterisee par l’expression restreinte de genes viraux, appeles genes de latence permettant au virus de persister tout au long de la vie. On definit trois latences virales (I, II et III) selon le profil d’expression des genes de latence codant les antigenes EBNAs (-1, -2, -3 et -LP) et les proteines membranaires LMPs (-1 et -2). L��immortalisation in vitro des lymphocytes B aboutit a des lignees cellulaires lymphoblastoides (LCL de latence III), exprimant la totalite des genes de latence. L’EBV est associee a des cancers (lymphome de Burkitt, lymphomes lies a un deficit immunitaire innee ou acquis, lymphome de Hodgkin, carcinome du rhinopharynx). Hors dans le lymphome de Burkitt, LMP-1 est exprimee dans toutes les pathologies malignes, et constitue l’oncogene majeur du virus. Les propr...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/64862237" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fe7070fcd49bd8eac387418b398a004e" rel="nofollow" data-download="{"attachment_id":76699194,"asset_id":64862237,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/76699194/download_file?st=MTczMjM5MTY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="117304007" href="https://independent.academia.edu/Tansoth%C3%A9aOUK">Tan-sothéa OUK</a><script data-card-contents-for-user="117304007" type="text/json">{"id":117304007,"first_name":"Tan-sothéa","last_name":"OUK","domain_name":"independent","page_name":"TansothéaOUK","display_name":"Tan-sothéa OUK","profile_url":"https://independent.academia.edu/Tansoth%C3%A9aOUK?f_ri=288801","photo":"https://0.academia-photos.com/117304007/28655465/26775044/s65_tan-soth_a.ouk.jpg"}</script></span></span></li><li class="js-paper-rank-work_64862237 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="64862237"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 64862237, container: ".js-paper-rank-work_64862237", }); 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$(".js-view-count[data-work-id=64862237]").text(description); $(".js-view-count-work_64862237").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_64862237").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="64862237"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="7710" href="https://www.academia.edu/Documents/in/Biology">Biology</a>, <script data-card-contents-for-ri="7710" type="text/json">{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=288801","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="288801" href="https://www.academia.edu/Documents/in/Apoptose">Apoptose</a><script data-card-contents-for-ri="288801" type="text/json">{"id":288801,"name":"Apoptose","url":"https://www.academia.edu/Documents/in/Apoptose?f_ri=288801","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=64862237]'), work: {"id":64862237,"title":"Rôle de la protéine LMP1 dans la balance survie/apoptose des cellules infectées par le virus d’Epstein-Barr","created_at":"2021-12-17T08:27:19.445-08:00","url":"https://www.academia.edu/64862237/R%C3%B4le_de_la_prot%C3%A9ine_LMP1_dans_la_balance_survie_apoptose_des_cellules_infect%C3%A9es_par_le_virus_d_Epstein_Barr?f_ri=288801","dom_id":"work_64862237","summary":"Le virus d’Epstein-Barr (EBV) est un herpesvirus humain qui infecte 90% de la population, mais l’infection est, le plus souvent, asymptomatique. Apres infection, le virus etablit une latence virale caracterisee par l’expression restreinte de genes viraux, appeles genes de latence permettant au virus de persister tout au long de la vie. On definit trois latences virales (I, II et III) selon le profil d’expression des genes de latence codant les antigenes EBNAs (-1, -2, -3 et -LP) et les proteines membranaires LMPs (-1 et -2). L��immortalisation in vitro des lymphocytes B aboutit a des lignees cellulaires lymphoblastoides (LCL de latence III), exprimant la totalite des genes de latence. L’EBV est associee a des cancers (lymphome de Burkitt, lymphomes lies a un deficit immunitaire innee ou acquis, lymphome de Hodgkin, carcinome du rhinopharynx). Hors dans le lymphome de Burkitt, LMP-1 est exprimee dans toutes les pathologies malignes, et constitue l’oncogene majeur du virus. Les propr...","downloadable_attachments":[{"id":76699194,"asset_id":64862237,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":117304007,"first_name":"Tan-sothéa","last_name":"OUK","domain_name":"independent","page_name":"TansothéaOUK","display_name":"Tan-sothéa OUK","profile_url":"https://independent.academia.edu/Tansoth%C3%A9aOUK?f_ri=288801","photo":"https://0.academia-photos.com/117304007/28655465/26775044/s65_tan-soth_a.ouk.jpg"}],"research_interests":[{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology?f_ri=288801","nofollow":false},{"id":288801,"name":"Apoptose","url":"https://www.academia.edu/Documents/in/Apoptose?f_ri=288801","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_62123687" data-work_id="62123687" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/62123687/Structure_activity_studies_on_therapeutic_potential_of_Thymoquinone_analogs_in_pancreatic_cancer">Structure-activity studies on therapeutic potential of Thymoquinone analogs in pancreatic cancer</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Purpose Pancreatic cancer (PC) is one of the deadliest of all tumors. Previously, we were the first to show that Thymoqui-none (TQ) derived from black seed (Nigella sativa) oil has anti-tumor activity against PC. However, the... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_62123687" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Purpose Pancreatic cancer (PC) is one of the deadliest of all tumors. Previously, we were the first to show that Thymoqui-none (TQ) derived from black seed (Nigella sativa) oil has anti-tumor activity against PC. However, the concentration of TQ required was ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/62123687" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c9431b56edae2f68182030080255b3d4" rel="nofollow" data-download="{"attachment_id":74969598,"asset_id":62123687,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/74969598/download_file?st=MTczMjM5MTY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="160682867" href="https://independent.academia.edu/padhyesubhash">subhash padhye</a><script data-card-contents-for-user="160682867" type="text/json">{"id":160682867,"first_name":"subhash","last_name":"padhye","domain_name":"independent","page_name":"padhyesubhash","display_name":"subhash padhye","profile_url":"https://independent.academia.edu/padhyesubhash?f_ri=288801","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_62123687 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="62123687"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 62123687, container: ".js-paper-rank-work_62123687", }); 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href="https://www.academia.edu/26724180/Ceramide_is_involved_in_triggering_of_cardiomyocyte_apoptosis_induced_by_ischemia_and_reperfusion">Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/26724180" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="33ae1b4832b315a78862d511e61aca82" rel="nofollow" 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})();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_9210527" data-work_id="9210527" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/9210527/l_Ascorbic_acid_vitamin_C_induces_the_apoptosis_of_B16_murine_melanoma_cells_via_a_caspase_8_independent_pathway">l-Ascorbic acid (vitamin C) induces the apoptosis of B16 murine melanoma cells via a caspase-8–independent pathway</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">l-Ascorbic acid (vitamin C) has been reported to play a role in the treatment and prevention of cancer. However, its specific mechanistic pathways remain obscure. This study was carried out to identify the sodium ascorbate–induced... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_9210527" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">l-Ascorbic acid (vitamin C) has been reported to play a role in the treatment and prevention of cancer. However, its specific mechanistic pathways remain obscure. This study was carried out to identify the sodium ascorbate–induced apoptotic pathway in B16F10 murine melanoma cells. Sodium ascorbate was found to induce the apoptosis of B16F10 murine melanoma in a time- and dose-dependent manner, and this was prevented by pretreatment with N-acetyl-l-cysteine (NAC), a well-known antioxidant. In fact, sodium ascorbate–treated B16F10 melanoma cells showed increased intracellular reactive oxygen species generation (ROS) levels. These results indicate that sodium ascorbate induced apoptosis in B16F10 murine melanoma cells by acting as a prooxidant. We examined the involvement of caspase-8 using a specific caspase-8 inhibitor (z-IETD-fmk) on the sodium ascorbate–induced apoptotic pathway. Cell death was found not to be inhibited by z-IETD-fmk treatment, indicating that sodium ascorbate–induced apoptosis is not mediated by caspase-8. In addition, we detected a reduction in the mitochondrial membrane potential during apoptosis and confirmed cytochrome-c release from mitochondria by immunoblotting. Taken together, it appears that the induction of a prooxidant state by sodium ascorbate and a subsequent reduction in mitochondrial membrane potential are involved in the apoptotic pathway of B16F10 murine melanoma cells, and that this occurs in a caspase-8–independent manner.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/9210527" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a7ad56c9d4cd316d7aa692dfca93b9e4" rel="nofollow" data-download="{"attachment_id":47850260,"asset_id":9210527,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47850260/download_file?st=MTczMjM5MTY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="21106297" href="https://independent.academia.edu/DaejinKim2">Daejin Kim</a><script data-card-contents-for-user="21106297" type="text/json">{"id":21106297,"first_name":"Daejin","last_name":"Kim","domain_name":"independent","page_name":"DaejinKim2","display_name":"Daejin Kim","profile_url":"https://independent.academia.edu/DaejinKim2?f_ri=288801","photo":"https://0.academia-photos.com/21106297/89959523/78685156/s65_daejin.kim.png"}</script></span></span></li><li class="js-paper-rank-work_9210527 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="9210527"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 9210527, container: ".js-paper-rank-work_9210527", }); 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However, its specific mechanistic pathways remain obscure. This study was carried out to identify the sodium ascorbate–induced apoptotic pathway in B16F10 murine melanoma cells. Sodium ascorbate was found to induce the apoptosis of B16F10 murine melanoma in a time- and dose-dependent manner, and this was prevented by pretreatment with N-acetyl-l-cysteine (NAC), a well-known antioxidant. In fact, sodium ascorbate–treated B16F10 melanoma cells showed increased intracellular reactive oxygen species generation (ROS) levels. These results indicate that sodium ascorbate induced apoptosis in B16F10 murine melanoma cells by acting as a prooxidant. We examined the involvement of caspase-8 using a specific caspase-8 inhibitor (z-IETD-fmk) on the sodium ascorbate–induced apoptotic pathway. Cell death was found not to be inhibited by z-IETD-fmk treatment, indicating that sodium ascorbate–induced apoptosis is not mediated by caspase-8. 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data-has-card-for-ri="531" href="https://www.academia.edu/Documents/in/Organic_Chemistry">Organic Chemistry</a>, <script data-card-contents-for-ri="531" type="text/json">{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry?f_ri=288801","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6021" href="https://www.academia.edu/Documents/in/Cancer">Cancer</a>, <script data-card-contents-for-ri="6021" type="text/json">{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=288801","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="24731" href="https://www.academia.edu/Documents/in/Apoptosis">Apoptosis</a>, <script data-card-contents-for-ri="24731" type="text/json">{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=288801","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="37834" href="https://www.academia.edu/Documents/in/Western_blotting">Western blotting</a><script data-card-contents-for-ri="37834" type="text/json">{"id":37834,"name":"Western blotting","url":"https://www.academia.edu/Documents/in/Western_blotting?f_ri=288801","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=28982040]'), work: {"id":28982040,"title":"Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells","created_at":"2016-10-07T06:42:29.614-07:00","url":"https://www.academia.edu/28982040/Coumarin_polysulfides_inhibit_cell_growth_and_induce_apoptosis_in_HCT116_colon_cancer_cells?f_ri=288801","dom_id":"work_28982040","summary":null,"downloadable_attachments":[{"id":49426950,"asset_id":28982040,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":54641526,"first_name":"Mathias","last_name":"Montenarh","domain_name":"independent","page_name":"MathiasMontenarh","display_name":"Mathias Montenarh","profile_url":"https://independent.academia.edu/MathiasMontenarh?f_ri=288801","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry?f_ri=288801","nofollow":false},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=288801","nofollow":false},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=288801","nofollow":false},{"id":37834,"name":"Western blotting","url":"https://www.academia.edu/Documents/in/Western_blotting?f_ri=288801","nofollow":false},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction?f_ri=288801"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line?f_ri=288801"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=288801"},{"id":81065,"name":"Phosphatase","url":"https://www.academia.edu/Documents/in/Phosphatase?f_ri=288801"},{"id":112330,"name":"Sulfides","url":"https://www.academia.edu/Documents/in/Sulfides?f_ri=288801"},{"id":112576,"name":"Cell Death","url":"https://www.academia.edu/Documents/in/Cell_Death?f_ri=288801"},{"id":193464,"name":"Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis","url":"https://www.academia.edu/Documents/in/Sodium_Dodecyl_Sulfate-Polyacrylamide_Gel_Electrophoresis?f_ri=288801"},{"id":288801,"name":"Apoptose","url":"https://www.academia.edu/Documents/in/Apoptose?f_ri=288801"},{"id":325790,"name":"Coumarins","url":"https://www.academia.edu/Documents/in/Coumarins?f_ri=288801"},{"id":728493,"name":"Bioorganic and medicinal Chemistry","url":"https://www.academia.edu/Documents/in/Bioorganic_and_medicinal_Chemistry?f_ri=288801"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation?f_ri=288801"},{"id":809799,"name":"Cell Cycle Arrest","url":"https://www.academia.edu/Documents/in/Cell_Cycle_Arrest?f_ri=288801"},{"id":1152821,"name":"Chemical Synthesis","url":"https://www.academia.edu/Documents/in/Chemical_Synthesis?f_ri=288801"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival?f_ri=288801"},{"id":1212103,"name":"Antineoplastic Agents","url":"https://www.academia.edu/Documents/in/Antineoplastic_Agents?f_ri=288801"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_11727483" data-work_id="11727483" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/11727483/Effects_of_the_extract_of_Anemopaegma_mirandum_Catuaba_on_Rotenone_induced_apoptosis_in_human_neuroblastomas_SH_SY5Y_cells">Effects of the extract of Anemopaegma mirandum (Catuaba) on Rotenone-induced apoptosis in human neuroblastomas SH-SY5Y cells</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/11727483" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="987f8e7ba439c941ddc8cbf325c91a89" rel="nofollow" data-download="{"attachment_id":46556230,"asset_id":11727483,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46556230/download_file?st=MTczMjM5MTY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="28765554" href="https://javeriana.academia.edu/GeorgeBarreto">George E Barreto</a><script data-card-contents-for-user="28765554" type="text/json">{"id":28765554,"first_name":"George","last_name":"Barreto","domain_name":"javeriana","page_name":"GeorgeBarreto","display_name":"George E Barreto","profile_url":"https://javeriana.academia.edu/GeorgeBarreto?f_ri=288801","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_11727483 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="11727483"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 11727483, container: ".js-paper-rank-work_11727483", }); });</script></li><li class="js-percentile-work_11727483 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 11727483; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_11727483"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_11727483 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="11727483"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 11727483; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=11727483]").text(description); $(".js-view-count-work_11727483").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_11727483").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="11727483"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">28</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="237" href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a>, <script data-card-contents-for-ri="237" type="text/json">{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=288801","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="2184" href="https://www.academia.edu/Documents/in/Electron_Microscopy">Electron Microscopy</a>, <script data-card-contents-for-ri="2184" type="text/json">{"id":2184,"name":"Electron Microscopy","url":"https://www.academia.edu/Documents/in/Electron_Microscopy?f_ri=288801","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="4391" href="https://www.academia.edu/Documents/in/EM">EM</a>, <script data-card-contents-for-ri="4391" type="text/json">{"id":4391,"name":"EM","url":"https://www.academia.edu/Documents/in/EM?f_ri=288801","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="14076" href="https://www.academia.edu/Documents/in/Transmission_Electron_Microscopy">Transmission Electron Microscopy</a><script data-card-contents-for-ri="14076" type="text/json">{"id":14076,"name":"Transmission Electron Microscopy","url":"https://www.academia.edu/Documents/in/Transmission_Electron_Microscopy?f_ri=288801","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=11727483]'), work: {"id":11727483,"title":"Effects of the extract of Anemopaegma mirandum (Catuaba) on Rotenone-induced apoptosis in human neuroblastomas SH-SY5Y cells","created_at":"2015-03-30T13:14:03.738-07:00","url":"https://www.academia.edu/11727483/Effects_of_the_extract_of_Anemopaegma_mirandum_Catuaba_on_Rotenone_induced_apoptosis_in_human_neuroblastomas_SH_SY5Y_cells?f_ri=288801","dom_id":"work_11727483","summary":null,"downloadable_attachments":[{"id":46556230,"asset_id":11727483,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":28765554,"first_name":"George","last_name":"Barreto","domain_name":"javeriana","page_name":"GeorgeBarreto","display_name":"George E Barreto","profile_url":"https://javeriana.academia.edu/GeorgeBarreto?f_ri=288801","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science?f_ri=288801","nofollow":false},{"id":2184,"name":"Electron Microscopy","url":"https://www.academia.edu/Documents/in/Electron_Microscopy?f_ri=288801","nofollow":false},{"id":4391,"name":"EM","url":"https://www.academia.edu/Documents/in/EM?f_ri=288801","nofollow":false},{"id":14076,"name":"Transmission Electron Microscopy","url":"https://www.academia.edu/Documents/in/Transmission_Electron_Microscopy?f_ri=288801","nofollow":false},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=288801"},{"id":48527,"name":"Phase Contrast Microscopy","url":"https://www.academia.edu/Documents/in/Phase_Contrast_Microscopy?f_ri=288801"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line?f_ri=288801"},{"id":61474,"name":"Brain","url":"https://www.academia.edu/Documents/in/Brain?f_ri=288801"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=288801"},{"id":112576,"name":"Cell Death","url":"https://www.academia.edu/Documents/in/Cell_Death?f_ri=288801"},{"id":165002,"name":"Cell Viability","url":"https://www.academia.edu/Documents/in/Cell_Viability?f_ri=288801"},{"id":175490,"name":"Programmed cell death","url":"https://www.academia.edu/Documents/in/Programmed_cell_death?f_ri=288801"},{"id":178851,"name":"Cytoprotection","url":"https://www.academia.edu/Documents/in/Cytoprotection?f_ri=288801"},{"id":184909,"name":"Structure Analysis","url":"https://www.academia.edu/Documents/in/Structure_Analysis?f_ri=288801"},{"id":193974,"name":"Neurons","url":"https://www.academia.edu/Documents/in/Neurons?f_ri=288801"},{"id":239480,"name":"Neurotoxins","url":"https://www.academia.edu/Documents/in/Neurotoxins?f_ri=288801"},{"id":288801,"name":"Apoptose","url":"https://www.academia.edu/Documents/in/Apoptose?f_ri=288801"},{"id":354056,"name":"Plant extracts","url":"https://www.academia.edu/Documents/in/Plant_extracts?f_ri=288801"},{"id":436755,"name":"Degeneration","url":"https://www.academia.edu/Documents/in/Degeneration?f_ri=288801"},{"id":499747,"name":"Cell Shape","url":"https://www.academia.edu/Documents/in/Cell_Shape?f_ri=288801"},{"id":789968,"name":"Extract","url":"https://www.academia.edu/Documents/in/Extract?f_ri=288801"},{"id":806503,"name":"Thiazoles","url":"https://www.academia.edu/Documents/in/Thiazoles?f_ri=288801"},{"id":1157148,"name":"Cell Survival","url":"https://www.academia.edu/Documents/in/Cell_Survival?f_ri=288801"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=288801"},{"id":1541077,"name":"Parkinson Disease","url":"https://www.academia.edu/Documents/in/Parkinson_Disease?f_ri=288801"},{"id":1953419,"name":"Neuroprotective Agents","url":"https://www.academia.edu/Documents/in/Neuroprotective_Agents?f_ri=288801"},{"id":2163893,"name":"Phase Contrast","url":"https://www.academia.edu/Documents/in/Phase_Contrast?f_ri=288801"},{"id":2256666,"name":"DNA fragmentation","url":"https://www.academia.edu/Documents/in/DNA_fragmentation?f_ri=288801"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_26106285" data-work_id="26106285" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/26106285/Anticancer_activity_of_novel_extracts_from_Cautleya_gracilis_Smith_Dandy_apoptosis_in_human_medullary_thyroid_carcinoma_cells">Anticancer activity of novel extracts from Cautleya gracilis (Smith) Dandy: apoptosis in human medullary thyroid carcinoma cells</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Medullary thyroid carcinoma (MTC) is a calcitonin-producing tumor of the thyroid arising from the parafollicular C-cells. MTC is poorly responsive to chemotherapy and radiotherapy, hence the only effective therapy is surgery. Based on... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_26106285" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Medullary thyroid carcinoma (MTC) is a calcitonin-producing tumor of the thyroid arising from the parafollicular C-cells. MTC is poorly responsive to chemotherapy and radiotherapy, hence the only effective therapy is surgery. Based on this fact, alternative strategies have been sought. The effects of Cautleya gracilis (Smith) Dandy were investigated for the first time in three human MTC cell lines and in MTC-transplanted mice. Proliferation and viability were quantified by cell counting, WST-1 tests, and ATP luminescent cell viability assays. Apoptosis was studied by DAPI staining, flow cytometry and luminescent assays for caspases 3/7, 8 and 9. A dose-dependent reduction of proliferation and an induction of apoptosis were found in all MTC cell lines, while normal fibroblasts were not impaired. Similar tumor inhibition was seen in heterotransplanted mice. Our in vitro and in vivo findings suggest a new potential clinical effect of Cautleya.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/26106285" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="36c0b1522db20ff55c5a246fe7f846f5" rel="nofollow" data-download="{"attachment_id":46455365,"asset_id":26106285,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/46455365/download_file?st=MTczMjM5MTY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="50021031" href="https://independent.academia.edu/BernhardSvejda">Bernhard Svejda</a><script data-card-contents-for-user="50021031" type="text/json">{"id":50021031,"first_name":"Bernhard","last_name":"Svejda","domain_name":"independent","page_name":"BernhardSvejda","display_name":"Bernhard Svejda","profile_url":"https://independent.academia.edu/BernhardSvejda?f_ri=288801","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_26106285 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="26106285"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 26106285, container: ".js-paper-rank-work_26106285", }); 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$(".js-view-count[data-work-id=26106285]").text(description); $(".js-view-count-work_26106285").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_26106285").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="26106285"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">14</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="6021" href="https://www.academia.edu/Documents/in/Cancer">Cancer</a>, <script data-card-contents-for-ri="6021" type="text/json">{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=288801","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="24731" href="https://www.academia.edu/Documents/in/Apoptosis">Apoptosis</a>, <script data-card-contents-for-ri="24731" type="text/json">{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=288801","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="50841" href="https://www.academia.edu/Documents/in/Caspases">Caspases</a>, <script data-card-contents-for-ri="50841" type="text/json">{"id":50841,"name":"Caspases","url":"https://www.academia.edu/Documents/in/Caspases?f_ri=288801","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a><script data-card-contents-for-ri="64568" type="text/json">{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=288801","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=26106285]'), work: {"id":26106285,"title":"Anticancer activity of novel extracts from Cautleya gracilis (Smith) Dandy: apoptosis in human medullary thyroid carcinoma cells","created_at":"2016-06-13T21:18:43.324-07:00","url":"https://www.academia.edu/26106285/Anticancer_activity_of_novel_extracts_from_Cautleya_gracilis_Smith_Dandy_apoptosis_in_human_medullary_thyroid_carcinoma_cells?f_ri=288801","dom_id":"work_26106285","summary":"Medullary thyroid carcinoma (MTC) is a calcitonin-producing tumor of the thyroid arising from the parafollicular C-cells. MTC is poorly responsive to chemotherapy and radiotherapy, hence the only effective therapy is surgery. Based on this fact, alternative strategies have been sought. The effects of Cautleya gracilis (Smith) Dandy were investigated for the first time in three human MTC cell lines and in MTC-transplanted mice. Proliferation and viability were quantified by cell counting, WST-1 tests, and ATP luminescent cell viability assays. Apoptosis was studied by DAPI staining, flow cytometry and luminescent assays for caspases 3/7, 8 and 9. A dose-dependent reduction of proliferation and an induction of apoptosis were found in all MTC cell lines, while normal fibroblasts were not impaired. Similar tumor inhibition was seen in heterotransplanted mice. Our in vitro and in vivo findings suggest a new potential clinical effect of Cautleya.","downloadable_attachments":[{"id":46455365,"asset_id":26106285,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":50021031,"first_name":"Bernhard","last_name":"Svejda","domain_name":"independent","page_name":"BernhardSvejda","display_name":"Bernhard Svejda","profile_url":"https://independent.academia.edu/BernhardSvejda?f_ri=288801","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=288801","nofollow":false},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=288801","nofollow":false},{"id":50841,"name":"Caspases","url":"https://www.academia.edu/Documents/in/Caspases?f_ri=288801","nofollow":false},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=288801","nofollow":false},{"id":84760,"name":"Mice","url":"https://www.academia.edu/Documents/in/Mice?f_ri=288801"},{"id":98925,"name":"Female","url":"https://www.academia.edu/Documents/in/Female?f_ri=288801"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=288801"},{"id":112576,"name":"Cell 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class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/3328165/Jacques_Monod_publie_le_hasard_et_la_n%C3%A9cessit%C3%A9">Jacques Monod publie le hasard et la nécessité</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/3328165" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="5dcf54e38066d6a54f2f99d8b02998b3" rel="nofollow" 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type="text/json">{"id":636926,"name":"Philosophie Des Sciences","url":"https://www.academia.edu/Documents/in/Philosophie_Des_Sciences?f_ri=288801","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="973234" href="https://www.academia.edu/Documents/in/Jacques_Monod">Jacques Monod</a>, <script data-card-contents-for-ri="973234" type="text/json">{"id":973234,"name":"Jacques Monod","url":"https://www.academia.edu/Documents/in/Jacques_Monod?f_ri=288801","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="973237" href="https://www.academia.edu/Documents/in/Le_Hasard_Et_La_Necessite">Le Hasard Et La Nécessité</a><script data-card-contents-for-ri="973237" type="text/json">{"id":973237,"name":"Le Hasard Et La Nécessité","url":"https://www.academia.edu/Documents/in/Le_Hasard_Et_La_Necessite?f_ri=288801","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=3328165]'), work: {"id":3328165,"title":"Jacques Monod publie le hasard et la nécessité","created_at":"2013-04-18T18:40:15.328-07:00","url":"https://www.academia.edu/3328165/Jacques_Monod_publie_le_hasard_et_la_n%C3%A9cessit%C3%A9?f_ri=288801","dom_id":"work_3328165","summary":null,"downloadable_attachments":[{"id":35349063,"asset_id":3328165,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":3854564,"first_name":"Antonine","last_name":"Nicoglou","domain_name":"iehca","page_name":"AntonineNicoglou","display_name":"Antonine Nicoglou","profile_url":"https://iehca.academia.edu/AntonineNicoglou?f_ri=288801","photo":"https://0.academia-photos.com/3854564/1536775/1866461/s65_antonine.nicoglou.jpg"}],"research_interests":[{"id":288801,"name":"Apoptose","url":"https://www.academia.edu/Documents/in/Apoptose?f_ri=288801","nofollow":false},{"id":636926,"name":"Philosophie Des Sciences","url":"https://www.academia.edu/Documents/in/Philosophie_Des_Sciences?f_ri=288801","nofollow":false},{"id":973234,"name":"Jacques Monod","url":"https://www.academia.edu/Documents/in/Jacques_Monod?f_ri=288801","nofollow":false},{"id":973237,"name":"Le Hasard Et La Nécessité","url":"https://www.academia.edu/Documents/in/Le_Hasard_Et_La_Necessite?f_ri=288801","nofollow":false},{"id":973240,"name":"Philosophie De La Biologie","url":"https://www.academia.edu/Documents/in/Philosophie_De_La_Biologie?f_ri=288801"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_45218726" data-work_id="45218726" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/45218726/An%C3%A9mie_h%C3%A9molytique_auto_immune_et_dys%C3%A9rythropo%C3%AF%C3%A8se_r%C3%A9v%C3%A9latrices_dun_d%C3%A9ficit_de_lapoptose_Fas_chez_3_enfants">Anémie hémolytique auto-immune et dysérythropoïèse révélatrices d'un déficit de l'apoptose Fas chez 3 enfants</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/45218726" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="ef7ac994f0ee973d7bbe93dbe5221761" rel="nofollow" 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href="https://www.academia.edu/13843117/Apoptosis_by_dietary_factors_the_suicide_solution_for_delaying_cancer_growth">Apoptosis by dietary factors: the suicide solution for delaying cancer growth</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13843117" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="fd7ba2f7a0e3ede40e3f644478d46db2" rel="nofollow" data-download="{"attachment_id":44889236,"asset_id":13843117,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button 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abundantly present in common fruits and vegetables, is recognized as a bioactive flavonoid shown to possess anti-inflammatory, antioxidant and anticancer properties. Epidemiologic studies... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_7192156" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Apigenin, a naturally occurring plant flavone, abundantly present in common fruits and vegetables, is recognized as a bioactive flavonoid shown to possess anti-inflammatory, antioxidant and anticancer properties. Epidemiologic studies suggest that a diet rich in flavones is related to a decreased risk of certain cancers, particularly cancers of the breast, digestive tract, skin, prostate and certain hematological malignancies. It has been suggested that apigenin may be protective in other diseases that are affected by oxidative process, such as cardiovascular and neurological disorders, although more research needs to be conducted in this regard. Human clinical trials examining the effect of supplementation of apigenin on disease prevention have not been conducted, although there is considerable potential for apigenin to be developed as a cancer chemopreventive agent.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/7192156" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="9d75bf00cb8b3acb14e5b3e16b1cec17" rel="nofollow" data-download="{"attachment_id":48567737,"asset_id":7192156,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48567737/download_file?st=MTczMjM5MTY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="12464697" href="https://independent.academia.edu/SANJEEVSHUKLA2">SANJEEV SHUKLA</a><script data-card-contents-for-user="12464697" type="text/json">{"id":12464697,"first_name":"SANJEEV","last_name":"SHUKLA","domain_name":"independent","page_name":"SANJEEVSHUKLA2","display_name":"SANJEEV SHUKLA","profile_url":"https://independent.academia.edu/SANJEEVSHUKLA2?f_ri=288801","photo":"https://0.academia-photos.com/12464697/169915948/159894324/s65_sanjeev.shukla.png"}</script></span></span></li><li class="js-paper-rank-work_7192156 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="7192156"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 7192156, container: ".js-paper-rank-work_7192156", }); 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Epidemiologic studies suggest that a diet rich in flavones is related to a decreased risk of certain cancers, particularly cancers of the breast, digestive tract, skin, prostate and certain hematological malignancies. It has been suggested that apigenin may be protective in other diseases that are affected by oxidative process, such as cardiovascular and neurological disorders, although more research needs to be conducted in this regard. Human clinical trials examining the effect of supplementation of apigenin on disease prevention have not been conducted, although there is considerable potential for apigenin to be developed as a cancer chemopreventive agent.","downloadable_attachments":[{"id":48567737,"asset_id":7192156,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":12464697,"first_name":"SANJEEV","last_name":"SHUKLA","domain_name":"independent","page_name":"SANJEEVSHUKLA2","display_name":"SANJEEV SHUKLA","profile_url":"https://independent.academia.edu/SANJEEVSHUKLA2?f_ri=288801","photo":"https://0.academia-photos.com/12464697/169915948/159894324/s65_sanjeev.shukla.png"}],"research_interests":[{"id":4531,"name":"Clinical Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial?f_ri=288801","nofollow":false},{"id":6021,"name":"Cancer","url":"https://www.academia.edu/Documents/in/Cancer?f_ri=288801","nofollow":false},{"id":8942,"name":"Treatment","url":"https://www.academia.edu/Documents/in/Treatment?f_ri=288801","nofollow":false},{"id":9113,"name":"Cell Cycle","url":"https://www.academia.edu/Documents/in/Cell_Cycle?f_ri=288801","nofollow":false},{"id":16765,"name":"Cancer Prevention","url":"https://www.academia.edu/Documents/in/Cancer_Prevention?f_ri=288801"},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=288801"},{"id":27240,"name":"Prevention","url":"https://www.academia.edu/Documents/in/Prevention?f_ri=288801"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=288801"},{"id":95655,"name":"Pharmaceutical","url":"https://www.academia.edu/Documents/in/Pharmaceutical?f_ri=288801"},{"id":99234,"name":"Animals","url":"https://www.academia.edu/Documents/in/Animals?f_ri=288801"},{"id":112576,"name":"Cell Death","url":"https://www.academia.edu/Documents/in/Cell_Death?f_ri=288801"},{"id":136717,"name":"Disease Prevention","url":"https://www.academia.edu/Documents/in/Disease_Prevention?f_ri=288801"},{"id":229398,"name":"Fruit and vegetables","url":"https://www.academia.edu/Documents/in/Fruit_and_vegetables?f_ri=288801"},{"id":288801,"name":"Apoptose","url":"https://www.academia.edu/Documents/in/Apoptose?f_ri=288801"},{"id":326939,"name":"Digestive Tract","url":"https://www.academia.edu/Documents/in/Digestive_Tract?f_ri=288801"},{"id":328449,"name":"Molecules","url":"https://www.academia.edu/Documents/in/Molecules?f_ri=288801"},{"id":335814,"name":"Research Needs","url":"https://www.academia.edu/Documents/in/Research_Needs?f_ri=288801"},{"id":469018,"name":"Neoplasms","url":"https://www.academia.edu/Documents/in/Neoplasms?f_ri=288801"},{"id":832148,"name":"Polyphenol","url":"https://www.academia.edu/Documents/in/Polyphenol?f_ri=288801"},{"id":1029023,"name":"Molecule","url":"https://www.academia.edu/Documents/in/Molecule?f_ri=288801"},{"id":1036777,"name":"Epidemiologic Studies","url":"https://www.academia.edu/Documents/in/Epidemiologic_Studies?f_ri=288801"},{"id":1739370,"name":"Apigenin","url":"https://www.academia.edu/Documents/in/Apigenin?f_ri=288801"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_3171122" data-work_id="3171122" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/3171122/Chromium_mediated_apoptosis_Involvement_of_DNA_dependent_protein_kinase_DNA_PK_and_differential_induction_of_p53_target_genes">Chromium-mediated apoptosis: Involvement of DNA-dependent protein kinase (DNA-PK) and differential induction of p53 target genes</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Cellular stress and DNA damage up-regulate and activate p53, fundamental for cell cycle control, senescence, DNA repair and apoptosis. The specific mechanism(s) that determine whether p53-dependent cell cycle arrest or p53-dependent... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_3171122" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Cellular stress and DNA damage up-regulate and activate p53, fundamental for cell cycle control, senescence, DNA repair and apoptosis. The specific mechanism(s) that determine whether p53-dependent cell cycle arrest or p53-dependent apoptosis prevails in response to specific DNA damage are poorly understood. In this study, we investigated two types of DNA damage, chromium treatment and gamma irradiation (IR) that induced similar levels of p53, but that mediated two distinct p53-dependent cell fates. Chromium exposure induced a robust DNA-dependent protein kinase (DNA-PK)-mediated apoptotic response that was accompanied by the rapid loss of the cyclin-dependent kinase inhibitor 1A (p21) protein, whereas IR treatment-induced cell cycle arrests that was supported by the rapid induction of p21. Inhibition of DNA-PK effectively blocked chromium-, but not IR-induced p53 stabilization and activation. In contrast, inhibition of ATM and ATR by caffeine had the inverse effect of blocking IR-, but not chromium-induced p53 stabilization and activation. Chromium exposure ablated p21 transcription but PUMA and Bax transcription was significantly enhanced compared to non-damaged cells. In contrast, IR treatment triggered significant p21 mRNA synthesis in addition to PUMA and Bax mRNA production. While chromium treatment enhanced the binding of p53 and RNA polymerase II (RNA Pol II) to both the p21 and PUMA promoters, RNA Pol II elongation was only observed along the PUMA gene and not the p21 gene. In contrast, following IR treatment, RNA Pol II elongation was observed on both p21 and PUMA. Chromium-induced apoptosis therefore involves DNA-PK-mediated p53 activation followed by preferential transcription of pro-apoptotic PUMA over anti-apoptotic p21 genes.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/3171122" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c4cd7a4c3113175700fc547f4d33c02f" rel="nofollow" data-download="{"attachment_id":50427103,"asset_id":3171122,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/50427103/download_file?st=MTczMjM5MTY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="3621625" href="https://epa.academia.edu/arthurchiu">arthur chiu</a><script data-card-contents-for-user="3621625" type="text/json">{"id":3621625,"first_name":"arthur","last_name":"chiu","domain_name":"epa","page_name":"arthurchiu","display_name":"arthur chiu","profile_url":"https://epa.academia.edu/arthurchiu?f_ri=288801","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_3171122 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="3171122"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 3171122, container: ".js-paper-rank-work_3171122", }); 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$(".js-view-count[data-work-id=3171122]").text(description); $(".js-view-count-work_3171122").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_3171122").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="3171122"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">21</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="9113" href="https://www.academia.edu/Documents/in/Cell_Cycle">Cell Cycle</a>, <script data-card-contents-for-ri="9113" type="text/json">{"id":9113,"name":"Cell Cycle","url":"https://www.academia.edu/Documents/in/Cell_Cycle?f_ri=288801","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22998" href="https://www.academia.edu/Documents/in/Gamma_Rays">Gamma Rays</a>, <script data-card-contents-for-ri="22998" type="text/json">{"id":22998,"name":"Gamma Rays","url":"https://www.academia.edu/Documents/in/Gamma_Rays?f_ri=288801","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="23066" href="https://www.academia.edu/Documents/in/DNA_damage">DNA damage</a>, <script data-card-contents-for-ri="23066" type="text/json">{"id":23066,"name":"DNA damage","url":"https://www.academia.edu/Documents/in/DNA_damage?f_ri=288801","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="23067" href="https://www.academia.edu/Documents/in/DNA_repair">DNA repair</a><script data-card-contents-for-ri="23067" type="text/json">{"id":23067,"name":"DNA repair","url":"https://www.academia.edu/Documents/in/DNA_repair?f_ri=288801","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=3171122]'), work: {"id":3171122,"title":"Chromium-mediated apoptosis: Involvement of DNA-dependent protein kinase (DNA-PK) and differential induction of p53 target genes","created_at":"2013-03-31T04:15:27.985-07:00","url":"https://www.academia.edu/3171122/Chromium_mediated_apoptosis_Involvement_of_DNA_dependent_protein_kinase_DNA_PK_and_differential_induction_of_p53_target_genes?f_ri=288801","dom_id":"work_3171122","summary":"Cellular stress and DNA damage up-regulate and activate p53, fundamental for cell cycle control, senescence, DNA repair and apoptosis. The specific mechanism(s) that determine whether p53-dependent cell cycle arrest or p53-dependent apoptosis prevails in response to specific DNA damage are poorly understood. In this study, we investigated two types of DNA damage, chromium treatment and gamma irradiation (IR) that induced similar levels of p53, but that mediated two distinct p53-dependent cell fates. Chromium exposure induced a robust DNA-dependent protein kinase (DNA-PK)-mediated apoptotic response that was accompanied by the rapid loss of the cyclin-dependent kinase inhibitor 1A (p21) protein, whereas IR treatment-induced cell cycle arrests that was supported by the rapid induction of p21. Inhibition of DNA-PK effectively blocked chromium-, but not IR-induced p53 stabilization and activation. In contrast, inhibition of ATM and ATR by caffeine had the inverse effect of blocking IR-, but not chromium-induced p53 stabilization and activation. Chromium exposure ablated p21 transcription but PUMA and Bax transcription was significantly enhanced compared to non-damaged cells. In contrast, IR treatment triggered significant p21 mRNA synthesis in addition to PUMA and Bax mRNA production. While chromium treatment enhanced the binding of p53 and RNA polymerase II (RNA Pol II) to both the p21 and PUMA promoters, RNA Pol II elongation was only observed along the PUMA gene and not the p21 gene. In contrast, following IR treatment, RNA Pol II elongation was observed on both p21 and PUMA. Chromium-induced apoptosis therefore involves DNA-PK-mediated p53 activation followed by preferential transcription of pro-apoptotic PUMA over anti-apoptotic p21 genes.","downloadable_attachments":[{"id":50427103,"asset_id":3171122,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":3621625,"first_name":"arthur","last_name":"chiu","domain_name":"epa","page_name":"arthurchiu","display_name":"arthur chiu","profile_url":"https://epa.academia.edu/arthurchiu?f_ri=288801","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":9113,"name":"Cell Cycle","url":"https://www.academia.edu/Documents/in/Cell_Cycle?f_ri=288801","nofollow":false},{"id":22998,"name":"Gamma Rays","url":"https://www.academia.edu/Documents/in/Gamma_Rays?f_ri=288801","nofollow":false},{"id":23066,"name":"DNA damage","url":"https://www.academia.edu/Documents/in/DNA_damage?f_ri=288801","nofollow":false},{"id":23067,"name":"DNA repair","url":"https://www.academia.edu/Documents/in/DNA_repair?f_ri=288801","nofollow":false},{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=288801"},{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction?f_ri=288801"},{"id":48057,"name":"DNA","url":"https://www.academia.edu/Documents/in/DNA?f_ri=288801"},{"id":64568,"name":"Humans","url":"https://www.academia.edu/Documents/in/Humans?f_ri=288801"},{"id":151778,"name":"Chromium","url":"https://www.academia.edu/Documents/in/Chromium?f_ri=288801"},{"id":233882,"name":"ATM","url":"https://www.academia.edu/Documents/in/ATM?f_ri=288801"},{"id":288801,"name":"Apoptose","url":"https://www.academia.edu/Documents/in/Apoptose?f_ri=288801"},{"id":572805,"name":"Puma","url":"https://www.academia.edu/Documents/in/Puma?f_ri=288801"},{"id":621993,"name":"Chrome","url":"https://www.academia.edu/Documents/in/Chrome?f_ri=288801"},{"id":736136,"name":"Protein 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}) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_10328952" data-work_id="10328952" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/10328952/Efficient_production_of_genetically_engineered_male_sterile_Arabidopsis_thaliana_using_anther_specific_promoters_and_genes_derived_from_Brassica_oleracea_and_B_rapa">Efficient production of genetically engineered, male-sterile Arabidopsis thaliana using anther-specific promoters and genes derived from Brassica oleracea and B. rapa</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Prevention of transgene flow from genetically modified crops to food crops and wild relatives is of concern in agricultural biotechnology. We used genes derived from food crops to produce complete male sterility as a strategy for gene... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_10328952" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Prevention of transgene flow from genetically modified crops to food crops and wild relatives is of concern in agricultural biotechnology. We used genes derived from food crops to produce complete male sterility as a strategy for gene confinement as well as to reduce the food purity concerns of consumers. Anther-specific promoters (A3, A6, A9, MS2, and MS5) were isolated from Brassica oleracea and B. rapa and fused to the β-glucuronidase (GUS) reporter gene and candidate genes for male sterility, including the cysteine proteases BoCysP1 and BoCP3, and negative regulatory components of phytohormonal responses involved in male development. These constructs were then introduced into Arabidopsis thaliana. GUS analyses revealed that A3, A6, and A9 had tapetum-specific promoter activity from the anther meiocyte stage. Male sterility was confirmed in tested constructs with protease or gibberellin insensitive (gai) genes. In particular, constructs with BoCysP1 driven by the A3 or A9 promoter most efficiently produced plants with complete male sterility. The tapetum and middle layer cells of anthers expressing BoCysP1 were swollen and excessively vacuolated when observed in transverse section. This suggests that the ectopic expression of cysteine protease in the meiocyte stage may inhibit programmed cell death. The gai gene also induced male sterility, although at a low frequency. This is the first report to show that plant cysteine proteases and gai from food crops are available as a novel tool for the development of genetically engineered male-sterile plants.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/10328952" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="4d69415c8baafb091bf3779368f9cf33" rel="nofollow" data-download="{"attachment_id":47435800,"asset_id":10328952,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47435800/download_file?st=MTczMjM5MTY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="25321952" href="https://affrc.academia.edu/MaiTsuda">Mai Tsuda</a><script data-card-contents-for-user="25321952" type="text/json">{"id":25321952,"first_name":"Mai","last_name":"Tsuda","domain_name":"affrc","page_name":"MaiTsuda","display_name":"Mai Tsuda","profile_url":"https://affrc.academia.edu/MaiTsuda?f_ri=288801","photo":"https://0.academia-photos.com/25321952/8045961/9010532/s65_mai.tsuda.jpg_oh_ec59ad84007000d83594450beb67758d_oe_55b123f0___gda___1437977421_5537c47482fa4b1a55ace32098d8cc7c"}</script></span></span></li><li class="js-paper-rank-work_10328952 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="10328952"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 10328952, container: ".js-paper-rank-work_10328952", }); 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We used genes derived from food crops to produce complete male sterility as a strategy for gene confinement as well as to reduce the food purity concerns of consumers. Anther-specific promoters (A3, A6, A9, MS2, and MS5) were isolated from Brassica oleracea and B. rapa and fused to the β-glucuronidase (GUS) reporter gene and candidate genes for male sterility, including the cysteine proteases BoCysP1 and BoCP3, and negative regulatory components of phytohormonal responses involved in male development. These constructs were then introduced into Arabidopsis thaliana. GUS analyses revealed that A3, A6, and A9 had tapetum-specific promoter activity from the anther meiocyte stage. Male sterility was confirmed in tested constructs with protease or gibberellin insensitive (gai) genes. In particular, constructs with BoCysP1 driven by the A3 or A9 promoter most efficiently produced plants with complete male sterility. The tapetum and middle layer cells of anthers expressing BoCysP1 were swollen and excessively vacuolated when observed in transverse section. This suggests that the ectopic expression of cysteine protease in the meiocyte stage may inhibit programmed cell death. The gai gene also induced male sterility, although at a low frequency. This is the first report to show that plant cysteine proteases and gai from food crops are available as a novel tool for the development of genetically engineered male-sterile plants.","downloadable_attachments":[{"id":47435800,"asset_id":10328952,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":25321952,"first_name":"Mai","last_name":"Tsuda","domain_name":"affrc","page_name":"MaiTsuda","display_name":"Mai Tsuda","profile_url":"https://affrc.academia.edu/MaiTsuda?f_ri=288801","photo":"https://0.academia-photos.com/25321952/8045961/9010532/s65_mai.tsuda.jpg_oh_ec59ad84007000d83594450beb67758d_oe_55b123f0___gda___1437977421_5537c47482fa4b1a55ace32098d8cc7c"}],"research_interests":[{"id":3442,"name":"Production","url":"https://www.academia.edu/Documents/in/Production?f_ri=288801","nofollow":false},{"id":4313,"name":"Gene Flow","url":"https://www.academia.edu/Documents/in/Gene_Flow?f_ri=288801","nofollow":false},{"id":5541,"name":"Plant 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js-work-link" href="https://www.academia.edu/61997764/Morte_Celular_por_Apoptose">Morte Celular por Apoptose</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Apoptose, ou morte celular programada, é um processo essencial para a manutenção do desenvolvimento dos seres vivos, sendo importante para eliminar células supérfluas ou defeituosas. Durante a apoptose, a célula sofre alterações... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_61997764" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Apoptose, ou morte celular programada, é um processo essencial para a manutenção do desenvolvimento dos seres vivos, sendo importante para eliminar células supérfluas ou defeituosas. Durante a apoptose, a célula sofre alterações morfológicas características desse tipo de morte celular. Tais alterações incluem a retração da célula, perda de aderência com a matriz extracelular e células vizinhas, condensação da cromatina, fragmentação internucleossômica do DNA e formação dos corpos apoptóticos. Muitas são as moléculas envolvidas no controle das vias de ativação da apoptose, dentre estas, as proteínas antiapoptóticas e pró-apoptóticas, além das caspases. Esse fenômeno biológico, além de desempenhar um papel importante no controle de diversos processos vitais, está associado a inúmeras doenças, como o câncer. A compreensão dos mecanismos apoptóticos permitiu o desenvolvimento de novas estratégias no tratamento do câncer. Tais estratégias são embasadas na indução da morte nas células tum...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/61997764" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="07d745a70da3b28e055348a306f1adf3" rel="nofollow" data-download="{"attachment_id":74882772,"asset_id":61997764,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/74882772/download_file?st=MTczMjM5MTY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="44461908" href="https://independent.academia.edu/IvanaGrivicich">Ivana Grivicich</a><script data-card-contents-for-user="44461908" type="text/json">{"id":44461908,"first_name":"Ivana","last_name":"Grivicich","domain_name":"independent","page_name":"IvanaGrivicich","display_name":"Ivana Grivicich","profile_url":"https://independent.academia.edu/IvanaGrivicich?f_ri=288801","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_61997764 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="61997764"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 61997764, container: ".js-paper-rank-work_61997764", }); 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Tais estratégias são embasadas na indução da morte nas células tum...","downloadable_attachments":[{"id":74882772,"asset_id":61997764,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":44461908,"first_name":"Ivana","last_name":"Grivicich","domain_name":"independent","page_name":"IvanaGrivicich","display_name":"Ivana Grivicich","profile_url":"https://independent.academia.edu/IvanaGrivicich?f_ri=288801","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":50841,"name":"Caspases","url":"https://www.academia.edu/Documents/in/Caspases?f_ri=288801","nofollow":false},{"id":288801,"name":"Apoptose","url":"https://www.academia.edu/Documents/in/Apoptose?f_ri=288801","nofollow":false}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_33973296" data-work_id="33973296" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div 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Cell death is often induced upon pathogen infection as part... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_6039352" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Cell death is a crucial process during development, homeostasis and immune regulation of multicellular organisms, and its dysregulation is associated with numerous pathologies. Cell death is often induced upon pathogen infection as part of the defense mechanism, and pathogens have evolved strategies to modulate host cell death. In this review, we will discuss the molecular mechanisms and physiological relevance of four major types of programmed cell death, namely apoptosis, necrosis, autophagic cell death and pyroptosis.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/6039352" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="e1963cb55c7badb7d72ba65b26fe3afe" rel="nofollow" data-download="{"attachment_id":49044798,"asset_id":6039352,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/49044798/download_file?st=MTczMjM5MTY3MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="9067420" href="https://vib.academia.edu/TomVandenBerghe">Tom Vanden Berghe</a><script data-card-contents-for-user="9067420" type="text/json">{"id":9067420,"first_name":"Tom","last_name":"Vanden Berghe","domain_name":"vib","page_name":"TomVandenBerghe","display_name":"Tom Vanden Berghe","profile_url":"https://vib.academia.edu/TomVandenBerghe?f_ri=288801","photo":"https://0.academia-photos.com/9067420/3146375/11307497/s65_tom.vanden_berghe.jpg"}</script></span></span></li><li class="js-paper-rank-work_6039352 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="6039352"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 6039352, container: ".js-paper-rank-work_6039352", }); 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type="text/json">{"id":24731,"name":"Apoptosis","url":"https://www.academia.edu/Documents/in/Apoptosis?f_ri=288801","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="27784" href="https://www.academia.edu/Documents/in/Gene_expression">Gene expression</a>, <script data-card-contents-for-ri="27784" type="text/json">{"id":27784,"name":"Gene expression","url":"https://www.academia.edu/Documents/in/Gene_expression?f_ri=288801","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="38831" href="https://www.academia.edu/Documents/in/Signal_Transduction">Signal Transduction</a><script data-card-contents-for-ri="38831" type="text/json">{"id":38831,"name":"Signal Transduction","url":"https://www.academia.edu/Documents/in/Signal_Transduction?f_ri=288801","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=6582741]'), work: 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