CINXE.COM

<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="yNLz8Si4NINooY2wo7sLsthgM1XRAlx/lpDBF8rqKTUVXETpx4L4djxPrtCLcqnw7g5/LXXigAdNWvHnhyPvaQ==" /> <meta name="citation_title" content="Lycopodine from Lycopodium clavatum extract inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation" /> <meta name="citation_publication_date" content="2010/01/01" /> <meta name="citation_journal_title" content="European journal of pharmacology" /> <meta name="citation_author" content="Dr. Suman Dutta" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/2304134/Lycopodine_from_Lycopodium_clavatum_extract_inhibits_proliferation_of_HeLa_cells_through_induction_of_apoptosis_via_caspase_3_activation" /> <meta name="twitter:title" content="Lycopodine from Lycopodium clavatum extract inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation" /> <meta name="twitter:description" content="Academia.edu is a platform for academics to share research papers." /> <meta name="twitter:image" content="https://0.academia-photos.com/491566/167949/73849486/s200_dr._suman.dutta.jpg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/2304134/Lycopodine_from_Lycopodium_clavatum_extract_inhibits_proliferation_of_HeLa_cells_through_induction_of_apoptosis_via_caspase_3_activation" /> <meta property="og:title" content="Lycopodine from Lycopodium clavatum extract inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="Lycopodine from Lycopodium clavatum extract inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation" /> <meta property="article:author" content="https://oxford.academia.edu/DrSumanDutta" /> <meta name="description" content="Lycopodine from Lycopodium clavatum extract inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation" /> <title>(PDF) Lycopodine from Lycopodium clavatum extract inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation | Dr. Suman Dutta - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/2304134/Lycopodine_from_Lycopodium_clavatum_extract_inhibits_proliferation_of_HeLa_cells_through_induction_of_apoptosis_via_caspase_3_activation" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '49879c2402910372f4abc62630a427bbe033d190'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1732400222000); window.Aedu.timeDifference = new Date().getTime() - 1732400222000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":null,"author":[{"@context":"https://schema.org","@type":"Person","name":"Dr. Suman Dutta"}],"contributor":[],"dateCreated":"2012-12-17","dateModified":"2024-11-13","datePublished":"2010-01-01","headline":"Lycopodine from Lycopodium clavatum extract inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation","inLanguage":"en","keywords":["Complementary and Alternative Medicine","Flow Cytometry","Cell Cycle","Apoptosis","Humans","Reactive Oxygen Species","Cell Death","Cytochrome C","Alkaloids","Cell Viability","Caspase","European","Apoptose","Fluorescent Antibody Technique","Plant extracts","Lycopodium","HeLa cells","Western blot","Molecular weight","Cell Proliferation","Extract","Alkanes","Mitochondrial Membrane Potential","Cell Survival","DNA fragmentation"],"locationCreated":null,"publication":"European journal of pharmacology","publisher":{"@context":"https://schema.org","@type":"Organization","name":"ncbi.nlm.nih.gov"},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/2304134/Lycopodine_from_Lycopodium_clavatum_extract_inhibits_proliferation_of_HeLa_cells_through_induction_of_apoptosis_via_caspase_3_activation","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":"oxford"}]}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-352e32ba4e89304dc0b4fa5b3952eef2198174c54cdb79066bc62e91c68a1a91.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-8d679e925718b5e8e4b18e9a4fab37f7eaa99e43386459376559080ac8f2856a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/text_button-73590134e40cdb49f9abdc8e796cc00dc362693f3f0f6137d6cf9bb78c318ce7.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-10fa40af19d25203774df2d4a03b9b5771b45109c2304968038e88a81d1215c5.css" /> </head> <body> <div id='react-modal'></div> <div class="js-upgrade-ie-banner" style="display: none; text-align: center; padding: 8px 0; background-color: #ebe480;"><p style="color: #000; font-size: 12px; margin: 0 0 4px;">Academia.edu no longer supports Internet Explorer.</p><p style="color: #000; font-size: 12px; margin: 0;">To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.querySelector('.js-upgrade-ie-banner').style.display = 'block'; }</script> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "0fefcfb4ef1fab14ba2769e696a7e33fd5845a567e4101679c8253cf1bdd49b6", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="WtWDe1FqVcHFFdAx+QfXzBdr6V1AVsFRRX+iS6ewh5SHWzRjvlCZNJH781HRznWOIQWlJeS2HSmetZK76nlByA==" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://www.academia.edu/2304134/Lycopodine_from_Lycopodium_clavatum_extract_inhibits_proliferation_of_HeLa_cells_through_induction_of_apoptosis_via_caspase_3_activation" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="3VYbeZe8/3cteT4DL3I88/yGkpIzI9phnmDxQjDQIGcA2KxheIYzgnmXHWMHu56xyuje6pfDBhlFqsGyfRnmOw==" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><input class="btn btn-primary btn-block g-recaptcha js-password-reset-submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" type="submit" value="Email me a link" /></form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script> <div class="header--container" id="main-header-container"><div class="header--inner-container header--inner-container-ds2"><div class="header-ds2--left-wrapper"><div class="header-ds2--left-wrapper-inner"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="hide-on-desktop-redesign" style="height: 24px; width: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hide-on-mobile-redesign" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a><div class="header--search-container header--search-container-ds2"><form class="js-SiteSearch-form select2-no-default-pills" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><svg style="width: 14px; height: 14px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="search" class="header--search-icon svg-inline--fa fa-search fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M505 442.7L405.3 343c-4.5-4.5-10.6-7-17-7H372c27.6-35.3 44-79.7 44-128C416 93.1 322.9 0 208 0S0 93.1 0 208s93.1 208 208 208c48.3 0 92.7-16.4 128-44v16.3c0 6.4 2.5 12.5 7 17l99.7 99.7c9.4 9.4 24.6 9.4 33.9 0l28.3-28.3c9.4-9.4 9.4-24.6.1-34zM208 336c-70.7 0-128-57.2-128-128 0-70.7 57.2-128 128-128 70.7 0 128 57.2 128 128 0 70.7-57.2 128-128 128z"></path></svg><input class="header--search-input header--search-input-ds2 js-SiteSearch-form-input" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" /></form></div></div></div><nav class="header--nav-buttons header--nav-buttons-ds2 js-main-nav"><a class="ds2-5-button ds2-5-button--secondary js-header-login-url header-button-ds2 header-login-ds2 hide-on-mobile-redesign" href="https://www.academia.edu/login" rel="nofollow">Log In</a><a class="ds2-5-button ds2-5-button--secondary header-button-ds2 hide-on-mobile-redesign" href="https://www.academia.edu/signup" rel="nofollow">Sign Up</a><button class="header--hamburger-button header--hamburger-button-ds2 hide-on-desktop-redesign js-header-hamburger-button"><div class="icon-bar"></div><div class="icon-bar" style="margin-top: 4px;"></div><div class="icon-bar" style="margin-top: 4px;"></div></button></nav></div><ul class="header--dropdown-container js-header-dropdown"><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/login" rel="nofollow">Log In</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/signup" rel="nofollow">Sign Up</a></li><li class="header--dropdown-row js-header-dropdown-expand-button"><button class="header--dropdown-button">more<svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="caret-down" class="header--dropdown-button-icon svg-inline--fa fa-caret-down fa-w-10" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path fill="currentColor" d="M31.3 192h257.3c17.8 0 26.7 21.5 14.1 34.1L174.1 354.8c-7.8 7.8-20.5 7.8-28.3 0L17.2 226.1C4.6 213.5 13.5 192 31.3 192z"></path></svg></button></li><li><ul class="header--expanded-dropdown-container"><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/about">About</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/press">Press</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://medium.com/@academia">Blog</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/documents">Papers</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/terms">Terms</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/privacy">Privacy</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/copyright">Copyright</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/hiring"><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="header--dropdown-row-icon svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg>We're Hiring!</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://support.academia.edu/"><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="header--dropdown-row-icon svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg>Help Center</a></li><li class="header--dropdown-row js-header-dropdown-collapse-button"><button class="header--dropdown-button">less<svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="caret-up" class="header--dropdown-button-icon svg-inline--fa fa-caret-up fa-w-10" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path fill="currentColor" d="M288.662 352H31.338c-17.818 0-26.741-21.543-14.142-34.142l128.662-128.662c7.81-7.81 20.474-7.81 28.284 0l128.662 128.662c12.6 12.599 3.676 34.142-14.142 34.142z"></path></svg></button></li></ul></li></ul></div> <script src="//a.academia-assets.com/assets/webpack_bundles/fast_loswp-bundle-bf3d831cde46cd0e142f29f81a3fc4ce5ab45a404c10c12a480e83de68aff851.js" defer="defer"></script><script>window.loswp = {}; window.loswp.author = 491566; window.loswp.bulkDownloadFilterCounts = {}; window.loswp.hasDownloadableAttachment = true; window.loswp.hasViewableAttachments = true; // TODO: just use routes for this window.loswp.loginUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F2304134%2FLycopodine_from_Lycopodium_clavatum_extract_inhibits_proliferation_of_HeLa_cells_through_induction_of_apoptosis_via_caspase_3_activation%3Fauto%3Ddownload"; window.loswp.translateUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F2304134%2FLycopodine_from_Lycopodium_clavatum_extract_inhibits_proliferation_of_HeLa_cells_through_induction_of_apoptosis_via_caspase_3_activation%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":50678725,"identifier":"Attachment_50678725","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":2304134,"created_at":"2012-12-17T13:37:13.388-08:00","from_world_paper_id":116657949,"updated_at":"2024-11-13T08:24:38.386-08:00","_data":{"publisher":"ncbi.nlm.nih.gov","grobid_abstract":"Crude ethanolic extract of the plant Lycopodium clavatum has long been used in complementary and alternative medicine for treating various liver ailments and Alzheimer's disease. It has also been claimed to have potential anti-cancer properties in vivo in mice chronically fed liver carcinogens, p-dimethylamino azobenzene (initiator) and phenobarbital (promoter). Incidentally, crude ethanolic extract of Lycopodium clavatum is a mixture of some 201 alkaloids. In order to ascertain if any major fraction can be attributed to have pronounced anti-cancer effect, we examined this major fraction by eluting the crude extract in petroleum ether:ethyl aetate (17:3 vol/vol;) solvent and tried to understand its underlying mechanism. Studies on morphological changes, cell viability and cytotoxicity by microscopy and FACS, Western blot and immunofluorescence of Bcl-2, Bax, cytochrome c, caspase-3 were conducted. Lycopodine was found to induce chromatin condensation, inter-nucleosomal DNA fragmentation and enhanced cell population in sub-G1 region along with increase in reactive oxygen species generation and mitochondrial membrane potential depolarization, release of cytochrome c and activation of caspase-3 which are the events closely involved in apoptosis. An overall analysis of results showed that Lycopodine considerably inhibited growth of HeLa cells which indicates its potential use in chemotherapy.","publication_date":"2010,1,1","publication_name":"European journal of pharmacology","grobid_abstract_attachment_id":"50678725"},"document_type":"paper","pre_hit_view_count_baseline":0,"quality":"high","language":"en","title":"Lycopodine from Lycopodium clavatum extract inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [491566]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":50678725,"attachmentType":"pdf"}"><img alt="First page of “Lycopodine from Lycopodium clavatum extract inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/50678725/mini_magick20190128-31366-168evv.png?1548673949" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Lycopodine from Lycopodium clavatum extract inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="491566" href="https://oxford.academia.edu/DrSumanDutta"><img alt="Profile image of Dr. Suman Dutta" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/491566/167949/73849486/s65_dr._suman.dutta.jpg" />Dr. Suman Dutta</a></div><p class="ds-work-card--detail ds2-5-body-sm">2010, European journal of pharmacology</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":50678725,"attachmentType":"pdf","workUrl":"https://www.academia.edu/2304134/Lycopodine_from_Lycopodium_clavatum_extract_inhibits_proliferation_of_HeLa_cells_through_induction_of_apoptosis_via_caspase_3_activation"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":50678725,"attachmentType":"pdf","workUrl":"https://www.academia.edu/2304134/Lycopodine_from_Lycopodium_clavatum_extract_inhibits_proliferation_of_HeLa_cells_through_induction_of_apoptosis_via_caspase_3_activation"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="50678725" data-landing_url="https://www.academia.edu/2304134/Lycopodine_from_Lycopodium_clavatum_extract_inhibits_proliferation_of_HeLa_cells_through_induction_of_apoptosis_via_caspase_3_activation" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="109504894" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/109504894/Diluted_Lycopodium_Induced_Cell_Death_and_Clinical_Improvement_in_Hepatocellular_Carcinoma">Diluted Lycopodium Induced Cell Death and Clinical Improvement in Hepatocellular Carcinoma</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="228835713" href="https://independent.academia.edu/DrSatadalDas">Dr.Satadal Das</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Clinical Oncology and Research</p><p class="ds-related-work--abstract ds2-5-body-sm">Hepatocellular carcinoma (HCC) is a common cancer with high incidence rate, and 5-year survival rate in HCC is less than 20%. Thus, in search of newer anticancer agents effective in HCC, we have explored possible usefulness of an alternative medicine Lycopodium against the human liver cancer cell line, HepG2 along with its clinical efficacy. The HepG2 cell line was challenged with Lycopodium 6C (diluted Lycopodium &lt;1pg /mL available as alternative medicine) along with vehicle alcohol control in 24 hours. The cytopathic effect and viability test with methylene blue stain were observed. The cells were harvested for total RNA extraction, and gene expression levels of targeted cytokines -Interferon gamma (IFN γ); Interleukins - IL-6, IL-8, IL-10, IL-1β, Transforming Growth Factor- TGF-β1, TGF-β3 and Tumor Necrosis Factor alpha (TNF-α) by RT-PCR were studied. DNA fragmentation assay and cell viability assay by MTT method were also tested. After ethical permission we applied this medic...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Diluted Lycopodium Induced Cell Death and Clinical Improvement in Hepatocellular Carcinoma","attachmentId":107610695,"attachmentType":"pdf","work_url":"https://www.academia.edu/109504894/Diluted_Lycopodium_Induced_Cell_Death_and_Clinical_Improvement_in_Hepatocellular_Carcinoma","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/109504894/Diluted_Lycopodium_Induced_Cell_Death_and_Clinical_Improvement_in_Hepatocellular_Carcinoma"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="117993816" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/117993816/Potentized_Homeopathic_Drug_Lycopodium_clavatum_5C_and_15C_Shows_an_Anticancer_Effect_on_HeLa_Cells_In_Vitro">Potentized Homeopathic Drug Lycopodium clavatum (5C and 15C) Shows an Anticancer Effect on HeLa Cells In Vitro</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="4211686" href="https://independent.academia.edu/AsmitaSamadder">Asmita Samadder</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Potentized Homeopathic Drug Lycopodium clavatum (5C and 15C) Shows an Anticancer Effect on HeLa Cells In Vitro","attachmentId":113934278,"attachmentType":"pdf","work_url":"https://www.academia.edu/117993816/Potentized_Homeopathic_Drug_Lycopodium_clavatum_5C_and_15C_Shows_an_Anticancer_Effect_on_HeLa_Cells_In_Vitro","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/117993816/Potentized_Homeopathic_Drug_Lycopodium_clavatum_5C_and_15C_Shows_an_Anticancer_Effect_on_HeLa_Cells_In_Vitro"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="21515848" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/21515848/Protective_potentials_of_a_plant_extract_Lycopodium_clavatum_on_mice_chronically_fed_hepato_carcinogens">Protective potentials of a plant extract (Lycopodium clavatum) on mice chronically fed hepato-carcinogens</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42612358" href="https://independent.academia.edu/AntaraBanerjee1">Antara Banerjee</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Indian journal of experimental biology, 2009</p><p class="ds-related-work--abstract ds2-5-body-sm">Chronic feeding of carcinogens p-dimethylamino azobenzene (initiator) and phenobarbital (promoter) for 90 and 120 days elevated activities of acid and alkaline phosphatases, levels of blood glucose and cortisol and decreased the activities of glutathione reductase, succinate dehydrogenase, and blood cholesterol and hemoglobin contents, and levels of serum estradiol and testosterone in mice. Levels of these biomarkers in both liver and spleen tissues were positively altered along with a significant reduction of tumor incidence in liver of carcinogen intoxicated mice treated with spore extract of Lycopodium clavatum. The results validate the use of this plant extract in complementary and alternative medicines against hepato-toxicity.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Protective potentials of a plant extract (Lycopodium clavatum) on mice chronically fed hepato-carcinogens","attachmentId":41966587,"attachmentType":"pdf","work_url":"https://www.academia.edu/21515848/Protective_potentials_of_a_plant_extract_Lycopodium_clavatum_on_mice_chronically_fed_hepato_carcinogens","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/21515848/Protective_potentials_of_a_plant_extract_Lycopodium_clavatum_on_mice_chronically_fed_hepato_carcinogens"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="78163678" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/78163678/Efficacy_of_ethanolic_spore_extract_of_i_Lycopodium_clavatum_i_in_reducing_induced_hepatotoxicity_and_genotoxicity_in_mice">Efficacy of ethanolic spore extract of <i>Lycopodium clavatum</i> in reducing induced hepatotoxicity and genotoxicity in mice</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="211532446" href="https://independent.academia.edu/AKhudaBukhsh">Anisur Khuda-Bukhsh</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Biological and Chemical Sciences, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Efficacy of ethanolic spore extract of \u003ci\u003eLycopodium clavatum\u003c/i\u003e in reducing induced hepatotoxicity and genotoxicity in mice","attachmentId":85307573,"attachmentType":"pdf","work_url":"https://www.academia.edu/78163678/Efficacy_of_ethanolic_spore_extract_of_i_Lycopodium_clavatum_i_in_reducing_induced_hepatotoxicity_and_genotoxicity_in_mice","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/78163678/Efficacy_of_ethanolic_spore_extract_of_i_Lycopodium_clavatum_i_in_reducing_induced_hepatotoxicity_and_genotoxicity_in_mice"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="64862676" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/64862676/A_better_understanding_of_pharmacological_activities_and_uses_of_phytochemicals_of_Lycopodium_clavatum_A_review">A better understanding of pharmacological activities and uses of phytochemicals of Lycopodium clavatum: A review</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="31849951" href="https://independent.academia.edu/MadhuNITHARRANJAN">NITHAR RANJAN Madhu</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2014</p><p class="ds-related-work--abstract ds2-5-body-sm">Lycopodium clavatum commonly known as club moss belongs to family Lycopodiaceae is a plant of great interest and is used in combating a wide variety of diseases in European and Asian countries. Crude extracts from various parts of the plant contain quinolizidine alkaloids. Several workers have reported various alkaloids derived from this plant and their therapeutic potentials, however, some reports are available on toxicity studies of alkaloids of this plant. In such a scenario, there is a need for better understanding of its ameliorating potential and its toxic actions. This review summarizes scientific findings and suggests areas where further research is needed.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A better understanding of pharmacological activities and uses of phytochemicals of Lycopodium clavatum: A review","attachmentId":76699458,"attachmentType":"pdf","work_url":"https://www.academia.edu/64862676/A_better_understanding_of_pharmacological_activities_and_uses_of_phytochemicals_of_Lycopodium_clavatum_A_review","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/64862676/A_better_understanding_of_pharmacological_activities_and_uses_of_phytochemicals_of_Lycopodium_clavatum_A_review"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="1348059" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/1348059/Hepatroprotective_action_of_potentized_lycopodium_clavatum_L">Hepatroprotective action of potentized lycopodium clavatum L.</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="489677" href="https://amity.academia.edu/susmitamitra">susmita mitra</a></div><p class="ds-related-work--metadata ds2-5-body-xs">British Homoeopathic …, 1990</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hepatroprotective action of potentized lycopodium clavatum L.","attachmentId":51018712,"attachmentType":"pdf","work_url":"https://www.academia.edu/1348059/Hepatroprotective_action_of_potentized_lycopodium_clavatum_L","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/1348059/Hepatroprotective_action_of_potentized_lycopodium_clavatum_L"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="103348495" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/103348495/Investigation_of_the_in_vitro_and_ex_vivo_acetylcholinesterase_and_antioxidant_activities_of_traditionally_used_Lycopodium_species_from_South_America_on_alkaloid_extracts">Investigation of the in vitro and ex vivo acetylcholinesterase and antioxidant activities of traditionally used Lycopodium species from South America on alkaloid extracts</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="273723022" href="https://independent.academia.edu/OrtegaMar%C3%ADaGabriela">María Gabriela Ortega</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Ethnopharmacology, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Investigation of the in vitro and ex vivo acetylcholinesterase and antioxidant activities of traditionally used Lycopodium species from South America on alkaloid extracts","attachmentId":103379327,"attachmentType":"pdf","work_url":"https://www.academia.edu/103348495/Investigation_of_the_in_vitro_and_ex_vivo_acetylcholinesterase_and_antioxidant_activities_of_traditionally_used_Lycopodium_species_from_South_America_on_alkaloid_extracts","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/103348495/Investigation_of_the_in_vitro_and_ex_vivo_acetylcholinesterase_and_antioxidant_activities_of_traditionally_used_Lycopodium_species_from_South_America_on_alkaloid_extracts"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="8820720" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/8820720/ANTIPROLIFERATIVE_AND_APOPTOSIS_INDUCING_ACTIVITY_OF_ALLELOCHEMICALS_PRESENT_IN_LEAF_AQUEOUS_EXTRACT_OF_TRADITIONALLY_USED_ANTITUMOR_MEDICINAL_PLANT_CLERODENDRUM_VISCOSUM_VENT">ANTIPROLIFERATIVE AND APOPTOSIS INDUCING ACTIVITY OF ALLELOCHEMICALS PRESENT IN LEAF AQUEOUS EXTRACT OF TRADITIONALLY USED ANTITUMOR MEDICINAL PLANT, CLERODENDRUM VISCOSUM VENT</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="19156097" href="https://independent.academia.edu/SANJIBRAYRAY">SANJIB RAY RAY</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"ANTIPROLIFERATIVE AND APOPTOSIS INDUCING ACTIVITY OF ALLELOCHEMICALS PRESENT IN LEAF AQUEOUS EXTRACT OF TRADITIONALLY USED ANTITUMOR MEDICINAL PLANT, CLERODENDRUM VISCOSUM VENT","attachmentId":35164381,"attachmentType":"pdf","work_url":"https://www.academia.edu/8820720/ANTIPROLIFERATIVE_AND_APOPTOSIS_INDUCING_ACTIVITY_OF_ALLELOCHEMICALS_PRESENT_IN_LEAF_AQUEOUS_EXTRACT_OF_TRADITIONALLY_USED_ANTITUMOR_MEDICINAL_PLANT_CLERODENDRUM_VISCOSUM_VENT","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/8820720/ANTIPROLIFERATIVE_AND_APOPTOSIS_INDUCING_ACTIVITY_OF_ALLELOCHEMICALS_PRESENT_IN_LEAF_AQUEOUS_EXTRACT_OF_TRADITIONALLY_USED_ANTITUMOR_MEDICINAL_PLANT_CLERODENDRUM_VISCOSUM_VENT"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="117993824" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/117993824/The_Potentized_Homeopathic_Drug_Lycopodium_clavatum_5C_and_15C_Has_Anti_cancer_Effect_on_HeLa_Cells_In_Vitro">The Potentized Homeopathic Drug, Lycopodium clavatum (5C and 15C) Has Anti-cancer Effect on HeLa Cells In Vitro</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="4211686" href="https://independent.academia.edu/AsmitaSamadder">Asmita Samadder</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Acupuncture and Meridian Studies, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Potentized Homeopathic Drug, Lycopodium clavatum (5C and 15C) Has Anti-cancer Effect on HeLa Cells In Vitro","attachmentId":113934330,"attachmentType":"pdf","work_url":"https://www.academia.edu/117993824/The_Potentized_Homeopathic_Drug_Lycopodium_clavatum_5C_and_15C_Has_Anti_cancer_Effect_on_HeLa_Cells_In_Vitro","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/117993824/The_Potentized_Homeopathic_Drug_Lycopodium_clavatum_5C_and_15C_Has_Anti_cancer_Effect_on_HeLa_Cells_In_Vitro"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="123243328" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/123243328/Lycopodine_triggers_apoptosis_by_modulating_5_lipoxygenase_and_depolarizing_mitochondrial_membrane_potential_in_androgen_sensitive_and_refractory_prostate_cancer_cells_without_modulating_p53_activity_Signaling_cascade_and_drug_DNA_interaction">Lycopodine triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity: Signaling cascade and drug–DNA interaction</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="211532446" href="https://independent.academia.edu/AKhudaBukhsh">Anisur Khuda-Bukhsh</a></div><p class="ds-related-work--metadata ds2-5-body-xs">European Journal of Pharmacology, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Lycopodine triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity: Signaling cascade and drug–DNA interaction","attachmentId":117721327,"attachmentType":"pdf","work_url":"https://www.academia.edu/123243328/Lycopodine_triggers_apoptosis_by_modulating_5_lipoxygenase_and_depolarizing_mitochondrial_membrane_potential_in_androgen_sensitive_and_refractory_prostate_cancer_cells_without_modulating_p53_activity_Signaling_cascade_and_drug_DNA_interaction","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/123243328/Lycopodine_triggers_apoptosis_by_modulating_5_lipoxygenase_and_depolarizing_mitochondrial_membrane_potential_in_androgen_sensitive_and_refractory_prostate_cancer_cells_without_modulating_p53_activity_Signaling_cascade_and_drug_DNA_interaction"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":50678725,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":50678725,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_50678725" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="63759808" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/63759808/Liriodenine_an_aporphine_alkaloid_from_and_shy_Enico_and_shy_santhellum_pulchrum_inhibits_proliferation_of_and_nbsp_human_ovarian_cancer_cells_through_induction_of_apoptosis_via_the_mitochondrial_signaling_pathway_and_blocking_cell_cycle_progression">Liriodenine, an aporphine alkaloid from &shy;Enico&shy;santhellum pulchrum, inhibits proliferation of&nbsp;human ovarian cancer cells through induction of apoptosis via the mitochondrial signaling pathway and blocking cell cycle progression</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="146428693" href="https://independent.academia.edu/NordinNoraziah">Noraziah Nordin</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Drug Design, Development and Therapy, 2015</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Liriodenine, an aporphine alkaloid from \u0026shy;Enico\u0026shy;santhellum pulchrum, inhibits proliferation of\u0026nbsp;human ovarian cancer cells through induction of apoptosis via the mitochondrial signaling pathway and blocking cell cycle progression","attachmentId":76077643,"attachmentType":"pdf","work_url":"https://www.academia.edu/63759808/Liriodenine_an_aporphine_alkaloid_from_and_shy_Enico_and_shy_santhellum_pulchrum_inhibits_proliferation_of_and_nbsp_human_ovarian_cancer_cells_through_induction_of_apoptosis_via_the_mitochondrial_signaling_pathway_and_blocking_cell_cycle_progression","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/63759808/Liriodenine_an_aporphine_alkaloid_from_and_shy_Enico_and_shy_santhellum_pulchrum_inhibits_proliferation_of_and_nbsp_human_ovarian_cancer_cells_through_induction_of_apoptosis_via_the_mitochondrial_signaling_pathway_and_blocking_cell_cycle_progression"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="45461335" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/45461335/Cytotoxic_and_apoptotic_effects_of_six_herbal_plants_against_the_human_hepatocarcinoma_HepG2_cell_line">Cytotoxic and apoptotic effects of six herbal plants against the human hepatocarcinoma (HepG2) cell line</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="12754608" href="https://independent.academia.edu/SahapatBarusrux">Sahapat Barusrux</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Chinese Medicine, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cytotoxic and apoptotic effects of six herbal plants against the human hepatocarcinoma (HepG2) cell line","attachmentId":65966909,"attachmentType":"pdf","work_url":"https://www.academia.edu/45461335/Cytotoxic_and_apoptotic_effects_of_six_herbal_plants_against_the_human_hepatocarcinoma_HepG2_cell_line","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/45461335/Cytotoxic_and_apoptotic_effects_of_six_herbal_plants_against_the_human_hepatocarcinoma_HepG2_cell_line"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="123008433" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/123008433/Lycopodium_clavatum_ekstrakt%C4%B1n%C4%B1n_SKBR_3_insan_meme_kanseri_h%C3%BCcreleri_%C3%BCzerindeki_apoptotik_etkileri">Lycopodium clavatum ekstraktının SKBR-3 insan meme kanseri hücreleri üzerindeki apoptotik etkileri</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="67032655" href="https://ankara.academia.edu/MohammadrezaDastouri">Mohammadreza Dastouri</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cukurova Medical Journal, 2023</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Lycopodium clavatum ekstraktının SKBR-3 insan meme kanseri hücreleri üzerindeki apoptotik etkileri","attachmentId":117545095,"attachmentType":"pdf","work_url":"https://www.academia.edu/123008433/Lycopodium_clavatum_ekstrakt%C4%B1n%C4%B1n_SKBR_3_insan_meme_kanseri_h%C3%BCcreleri_%C3%BCzerindeki_apoptotik_etkileri","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/123008433/Lycopodium_clavatum_ekstrakt%C4%B1n%C4%B1n_SKBR_3_insan_meme_kanseri_h%C3%BCcreleri_%C3%BCzerindeki_apoptotik_etkileri"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="117873169" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/117873169/Evaluating_the_effect_of_lycopene_from_Lycopersicum_esculentum_on_apoptosis_during_NDEA_induced_hepatocarcinogenesis">Evaluating the effect of lycopene from Lycopersicum esculentum on apoptosis during NDEA induced hepatocarcinogenesis</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="288525155" href="https://independent.academia.edu/PRACHIGUPTA420">PRACHI GUPTA</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biochemical and Biophysical Research Communications, 2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Evaluating the effect of lycopene from Lycopersicum esculentum on apoptosis during NDEA induced hepatocarcinogenesis","attachmentId":113624772,"attachmentType":"pdf","work_url":"https://www.academia.edu/117873169/Evaluating_the_effect_of_lycopene_from_Lycopersicum_esculentum_on_apoptosis_during_NDEA_induced_hepatocarcinogenesis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/117873169/Evaluating_the_effect_of_lycopene_from_Lycopersicum_esculentum_on_apoptosis_during_NDEA_induced_hepatocarcinogenesis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="4" data-entity-id="111726709" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/111726709/Assessment_of_In_Vivo_and_In_Vitro_Anti_Tumoral_Effects_of_Lycium_barbarum_Extract_on_Ehrlich_Ascites_Tumor_Cells_Histopathology_DNA_damage_and_AgNOR">Assessment of In Vivo and In Vitro Anti-Tumoral Effects of Lycium barbarum Extract on Ehrlich Ascites Tumor Cells : Histopathology, DNA damage and AgNOR</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="99083254" href="https://independent.academia.edu/%C3%9ClgerHarun">Harun Ülger</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Research Square (Research Square), 2023</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Assessment of In Vivo and In Vitro Anti-Tumoral Effects of Lycium barbarum Extract on Ehrlich Ascites Tumor Cells : Histopathology, DNA damage and AgNOR","attachmentId":109177886,"attachmentType":"pdf","work_url":"https://www.academia.edu/111726709/Assessment_of_In_Vivo_and_In_Vitro_Anti_Tumoral_Effects_of_Lycium_barbarum_Extract_on_Ehrlich_Ascites_Tumor_Cells_Histopathology_DNA_damage_and_AgNOR","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/111726709/Assessment_of_In_Vivo_and_In_Vitro_Anti_Tumoral_Effects_of_Lycium_barbarum_Extract_on_Ehrlich_Ascites_Tumor_Cells_Histopathology_DNA_damage_and_AgNOR"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="5" data-entity-id="91065034" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/91065034/Potential_Antitumor_Activity_and_Apoptosis_Induction_of_Glossostemon_bruguieri_Root_Extract_against_Hepatocellular_Carcinoma_Cells">Potential Antitumor Activity and Apoptosis Induction of Glossostemon bruguieri Root Extract against Hepatocellular Carcinoma Cells</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="69639037" href="https://independent.academia.edu/DrMonaAlwhibi">Dr. Mona Alwhibi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Evidence-based complementary and alternative medicine : eCAM, 2017</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Potential Antitumor Activity and Apoptosis Induction of Glossostemon bruguieri Root Extract against Hepatocellular Carcinoma Cells","attachmentId":94457324,"attachmentType":"pdf","work_url":"https://www.academia.edu/91065034/Potential_Antitumor_Activity_and_Apoptosis_Induction_of_Glossostemon_bruguieri_Root_Extract_against_Hepatocellular_Carcinoma_Cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/91065034/Potential_Antitumor_Activity_and_Apoptosis_Induction_of_Glossostemon_bruguieri_Root_Extract_against_Hepatocellular_Carcinoma_Cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="6" data-entity-id="62870780" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/62870780/In_Vitro_Anticancer_Potential_of_Berberis_lycium_Royle_Extracts_against_Human_Hepatocarcinoma_HepG2_Cells">In Vitro Anticancer Potential of Berberis lycium Royle Extracts against Human Hepatocarcinoma (HepG2) Cells</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47750684" href="https://independent.academia.edu/ShahAabid">Aabid Shah</a></div><p class="ds-related-work--metadata ds2-5-body-xs">BioMed Research International</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"In Vitro Anticancer Potential of Berberis lycium Royle Extracts against Human Hepatocarcinoma (HepG2) Cells","attachmentId":75497638,"attachmentType":"pdf","work_url":"https://www.academia.edu/62870780/In_Vitro_Anticancer_Potential_of_Berberis_lycium_Royle_Extracts_against_Human_Hepatocarcinoma_HepG2_Cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/62870780/In_Vitro_Anticancer_Potential_of_Berberis_lycium_Royle_Extracts_against_Human_Hepatocarcinoma_HepG2_Cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="7" data-entity-id="78721665" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/78721665/In_Vitro_Screening_for_Antitumour_Activity_of_Clinopodium_vulgare_L_Lamiaceae_Extracts">In Vitro Screening for Antitumour Activity of Clinopodium vulgare L. (Lamiaceae) Extracts</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="27080205" href="https://independent.academia.edu/BalikDzhambazov">Balik Dzhambazov</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biological & Pharmaceutical Bulletin, 2002</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"In Vitro Screening for Antitumour Activity of Clinopodium vulgare L. (Lamiaceae) Extracts","attachmentId":85669349,"attachmentType":"pdf","work_url":"https://www.academia.edu/78721665/In_Vitro_Screening_for_Antitumour_Activity_of_Clinopodium_vulgare_L_Lamiaceae_Extracts","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/78721665/In_Vitro_Screening_for_Antitumour_Activity_of_Clinopodium_vulgare_L_Lamiaceae_Extracts"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="8" data-entity-id="29090724" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/29090724/Role_of_Lycopersicon_esculentum_in_diethylnitrosamine_induced_and_phenobarbital_promoted_hepatocellular_carcinoma">Role of Lycopersicon esculentum in diethylnitrosamine‑induced and phenobarbital‑promoted hepatocellular carcinoma</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="55136664" href="https://independent.academia.edu/BasavarajKoti">Basavaraj Koti</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="14525723" href="https://klescoph.academia.edu/BHRIGUKUMARDAS">BHRIGU KUMAR DAS</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Role of Lycopersicon esculentum in diethylnitrosamine‑induced and phenobarbital‑promoted hepatocellular carcinoma","attachmentId":49539544,"attachmentType":"pdf","work_url":"https://www.academia.edu/29090724/Role_of_Lycopersicon_esculentum_in_diethylnitrosamine_induced_and_phenobarbital_promoted_hepatocellular_carcinoma","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/29090724/Role_of_Lycopersicon_esculentum_in_diethylnitrosamine_induced_and_phenobarbital_promoted_hepatocellular_carcinoma"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="9" data-entity-id="27483588" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/27483588/Hepatoprotective_effects_of_ethanol_extract_of_Alpinia_calcarata_Rosc_EEAC_on_Ehrlich_Ascites_Carcinoma_EAC_induced_carcinogenesis_in_experimental_mice_model">Hepatoprotective effects of ethanol extract of Alpinia calcarata Rosc (EEAC) on Ehrlich Ascites Carcinoma (EAC) induced carcinogenesis in experimental mice model</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="35676327" href="https://rubd.academia.edu/FarhadulIslam">Farhadul Islam</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2013</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hepatoprotective effects of ethanol extract of Alpinia calcarata Rosc (EEAC) on Ehrlich Ascites Carcinoma (EAC) induced carcinogenesis in experimental mice model","attachmentId":47739997,"attachmentType":"pdf","work_url":"https://www.academia.edu/27483588/Hepatoprotective_effects_of_ethanol_extract_of_Alpinia_calcarata_Rosc_EEAC_on_Ehrlich_Ascites_Carcinoma_EAC_induced_carcinogenesis_in_experimental_mice_model","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/27483588/Hepatoprotective_effects_of_ethanol_extract_of_Alpinia_calcarata_Rosc_EEAC_on_Ehrlich_Ascites_Carcinoma_EAC_induced_carcinogenesis_in_experimental_mice_model"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="10" data-entity-id="114727370" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/114727370/Hedyotiscorymbosa_L_Lamk_The_Potential_Inhibitor_Extract_of_Oral_Cancer_Cell_Progressivity_in_Benzopyrene_Induced_Rattus_Novergicus">Hedyotiscorymbosa (L.) Lamk - The Potential Inhibitor Extract of Oral Cancer Cell Progressivity in Benzopyrene Induced Rattus Novergicus</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="27729030" href="https://independent.academia.edu/BambangSumaryono1">Bambang Sumaryono</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2018</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hedyotiscorymbosa (L.) Lamk - The Potential Inhibitor Extract of Oral Cancer Cell Progressivity in Benzopyrene Induced Rattus Novergicus","attachmentId":111345566,"attachmentType":"pdf","work_url":"https://www.academia.edu/114727370/Hedyotiscorymbosa_L_Lamk_The_Potential_Inhibitor_Extract_of_Oral_Cancer_Cell_Progressivity_in_Benzopyrene_Induced_Rattus_Novergicus","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/114727370/Hedyotiscorymbosa_L_Lamk_The_Potential_Inhibitor_Extract_of_Oral_Cancer_Cell_Progressivity_in_Benzopyrene_Induced_Rattus_Novergicus"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="11" data-entity-id="98964083" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/98964083/Cytotoxic_and_Antitumor_Activity_of_the_Extract_of_Clerodendron_infortunatum_A_Mechanistic_Study">Cytotoxic and Antitumor Activity of the Extract of Clerodendron infortunatum: A Mechanistic Study</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="2333761" href="https://independent.academia.edu/KNair">Krishnan Nair</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cytotoxic and Antitumor Activity of the Extract of Clerodendron infortunatum: A Mechanistic Study","attachmentId":100175117,"attachmentType":"pdf","work_url":"https://www.academia.edu/98964083/Cytotoxic_and_Antitumor_Activity_of_the_Extract_of_Clerodendron_infortunatum_A_Mechanistic_Study","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/98964083/Cytotoxic_and_Antitumor_Activity_of_the_Extract_of_Clerodendron_infortunatum_A_Mechanistic_Study"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="12" data-entity-id="45461336" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/45461336/Evaluation_of_the_anticancer_potential_of_six_herbs_against_a_hepatoma_cell_line">Evaluation of the anticancer potential of six herbs against a hepatoma cell line</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="12754608" href="https://independent.academia.edu/SahapatBarusrux">Sahapat Barusrux</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Chinese Medicine, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Evaluation of the anticancer potential of six herbs against a hepatoma cell line","attachmentId":65966899,"attachmentType":"pdf","work_url":"https://www.academia.edu/45461336/Evaluation_of_the_anticancer_potential_of_six_herbs_against_a_hepatoma_cell_line","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/45461336/Evaluation_of_the_anticancer_potential_of_six_herbs_against_a_hepatoma_cell_line"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related topics</h2><div class="ds-research-interests--pills-container"><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="4083" href="https://www.academia.edu/Documents/in/Complementary_and_Alternative_Medicine">Complementary and Alternative Me...</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="6599" href="https://www.academia.edu/Documents/in/Flow_Cytometry">Flow Cytometry</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="9113" href="https://www.academia.edu/Documents/in/Cell_Cycle">Cell Cycle</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="24731" href="https://www.academia.edu/Documents/in/Apoptosis">Apoptosis</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="64568" href="https://www.academia.edu/Documents/in/Humans">Humans</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="82978" href="https://www.academia.edu/Documents/in/Reactive_Oxygen_Species">Reactive Oxygen Species</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="112576" href="https://www.academia.edu/Documents/in/Cell_Death">Cell Death</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="116476" href="https://www.academia.edu/Documents/in/Cytochrome_C">Cytochrome C</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="161562" href="https://www.academia.edu/Documents/in/Alkaloids">Alkaloids</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="165002" href="https://www.academia.edu/Documents/in/Cell_Viability">Cell Viability</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="247477" href="https://www.academia.edu/Documents/in/Caspase">Caspase</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="279027" href="https://www.academia.edu/Documents/in/European">European</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="288801" href="https://www.academia.edu/Documents/in/Apoptose">Apoptose</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="323597" href="https://www.academia.edu/Documents/in/Fluorescent_Antibody_Technique">Fluorescent Antibody Technique</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="354056" href="https://www.academia.edu/Documents/in/Plant_extracts">Plant extracts</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="360912" href="https://www.academia.edu/Documents/in/Lycopodium">Lycopodium</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="422325" href="https://www.academia.edu/Documents/in/HeLa_cells">HeLa cells</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="462111" href="https://www.academia.edu/Documents/in/Western_blot">Western blot</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="695018" href="https://www.academia.edu/Documents/in/Molecular_weight">Molecular weight</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="782251" href="https://www.academia.edu/Documents/in/Cell_Proliferation">Cell Proliferation</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="789968" href="https://www.academia.edu/Documents/in/Extract">Extract</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="1145788" href="https://www.academia.edu/Documents/in/Alkanes">Alkanes</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="1148360" href="https://www.academia.edu/Documents/in/Mitochondrial_Membrane_Potential">Mitochondrial Membrane Potential</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="1157148" href="https://www.academia.edu/Documents/in/Cell_Survival">Cell Survival</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="2256666" href="https://www.academia.edu/Documents/in/DNA_fragmentation">DNA fragmentation</a></div></div></div></div></div><div class="footer--content"><ul class="footer--main-links hide-on-mobile"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a rel="nofollow" href="https://medium.com/academia">Blog</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px; position: relative; bottom: -1px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a href="https://support.academia.edu/"><svg style="width: 12px; height: 12px; position: relative; bottom: -1px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer--research-interests"><li>Find new research papers in:</li><li><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul><ul class="footer--legal-links hide-on-mobile"><li><a href="https://www.academia.edu/terms">Terms</a></li><li><a href="https://www.academia.edu/privacy">Privacy</a></li><li><a href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2024</li></ul></div> </body> </html>