CAR T-REX Aims to Bolster Anti-Tumoural Immune Response

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If successful, the grant could massively improve treatment outcomes for patients. </div> </div> <div class="header-graphic flex-1"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Cell%20and%20Gene/CAR-T-REX-Aims-to-Bolster-Anti-Tumoural-Immune-Response-.jpg" class="header-graphic-image"> </div> </div> </div> </div> <div class="container-wrapper"> <div class="wide-container"> <div class="content"> <div class="content-body text-gap">  <p>CAR T-REX – an international European consortium working towards improved CAR-T therapies – has been the beneficiary of a â‚¬2.7m grant from the EIC. </p>   <p>The funds will go towards its flagship project, which aims to improve the safety and efficacy of CAR-T-based solid tumour-targeted cell therapies. </p>   <p>While highly-personalised autologous CAR-T therapies have dramatically changed the treatment landscape, broader clinical use is limited by constraints such as high manufacturing costs and deleterious side effects.</p>   <ul> <li><a href="https://oxfordglobal.com/cell/resources/3d-cell-model-approaches-for-disease-monitoring-and-detection/" target="_blank" rel="noreferrer noopener">3D heart models for monitoring cardiovascular disease</a></li>   <li><a href="https://oxfordglobal.com/cell/resources/metabolic-modelling-and-machine-learning-technologies-in-cell-and-gene-manufacturing/" target="_blank" rel="noreferrer noopener">How can machine learning approaches help with metabolic modelling in manufacture?</a></li>   <li><a href="https://oxfordglobal.com/cell/resources/cell-and-gene-manufacturing-approaches-and-winning-strategies-for-commercialisation-and-scale-up/">Winning strategies for CGT manufacturing and scale-up</a></li> </ul>   <p></p>   <p>To address these shortcomings, CAR-T-REX aims to combine non-viral gene delivery with the precise genome editing of T cell autoregulatory pathways.</p>   <p>Researchers involved with the project hope this will overcome the mechanisms by which solid tumours neutralise the body's anti-tumoural immune response, extending the utility and safety of current CAR-T technologies. </p>   <p>To this end, the CAR T-REX consortium aims to provide the foundation for an improved technology, with potential for significant scientific and societal impacts. </p>   <h2 id="h-cell-therapies-for-patients-with-solid-tumours"><strong>Cell Therapies for Patients with Solid Tumours </strong></h2>   <p>By combining novel approaches to genome editing and non-viral gene delivery, CAR T-REX will explore the engineering of transcriptional networks in CAR-T cells to selectively circumvent T-cell exhaustion in the tumour microenvironment (TME). </p>   <p>The consortium aims to achieve this by constructing novel auto-regulated genetic circuits controlled by microRNAs in immune checkpoint inhibitors. </p>   <p>While newly-approved CAR-T cell therapies have promised a revolution in treatment for diseases such as leukaemia and myelodysplastic syndromes, treatment constraints have persisted for patients with comorbidities or lesions in their central nervous system (CNS). </p>   <p>One persistent challenge for healthcare providers has concerned deciding where stem cell transplant fits in with other therapies involved in the treatment sequence following the arrival of CAR-T therapies.</p>   <p>It is hoped that the new approach being pioneered by CAR T-REX will help in addressing incidental issues such as toxicity.</p>   <p><em>Want to receive the latest industry announcements on cell manufacture and development? </em><a href="https://oxfordglobal.com/cell/newsletter/" target="_blank" rel="noreferrer noopener"><em>Sign up for our Cell series newsletter</em></a><em> to get up-to-date news each month. If you'd like to know more about our upcoming 3D Cell Culture conference, </em><a href="https://oxfordglobal.com/3d-cell-culture/" target="_blank" rel="noreferrer noopener"><em>visit our event website</em></a><em> to download an agenda and register your interest.</em></p>  <div class="content-body-footer"> </div> </div> <div class="content-sidebar"> <div class="related-articles"> <h3 class="center">Related Resources</h3> <div class="article"> <a href="/nextgen-biomed/resources/sgs-biologics-services"> <div class="cover-graphic"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Cell%20and%20Gene/Cell%20%26%20Gene%20Whitepaper.png" class="cover-graphic-image"> </div> </a><div class="content"><a href="/nextgen-biomed/resources/sgs-biologics-services"> <h4> SGS Biologics Services </h4> <div class="abstract"> </div> <div class="read-more"> <a href="/nextgen-biomed/resources/sgs-biologics-services" class="read-more-link">Read More</a> </div></a> </div> </div> <div class="article"> <a href="/nextgen-biomed/resources/sgs-biosafety-characterisation-services"> <div class="cover-graphic"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Cell%20and%20Gene/Cell%20%26%20Gene%20Whitepaper.png" class="cover-graphic-image"> </div> </a><div class="content"><a href="/nextgen-biomed/resources/sgs-biosafety-characterisation-services"> <h4> SGS Biosafety & Characterisation Services </h4> <div class="abstract"> </div> <div class="read-more"> <a href="/nextgen-biomed/resources/sgs-biosafety-characterisation-services" class="read-more-link">Read More</a> </div></a> </div> </div> </div> <div class="related-online-activities"> <h3 class="center">Related Online Activities</h3> Join the conversation with our upcoming Monthly Science Exchanges and Webinars: <div class="online-activity"> <div class="heading-smallcaps"> 01/11/24 </div> <a href="/nextgen-biomed/online#Process%20Challenges%20in%20ATMP%20Development:%20Overcoming%20Hurdles%20for%20Successful%20Manufacturing">Process Challenges in ATMP Development: Overcoming Hurdles for Successful Manufacturing</a> </div> </div> </div> </div> </div> </div> </div> <div class="newsletter-cta"> <h2 class="heading">Subscribe to our newsletter</h2> <div class="message"> Sign up for our monthly Newsletter to keep up with all things NextGen Biomed </div> <div class="button-wrapper"> <a href="#" class="button hs-cta-trigger-button hs-cta-trigger-button-177053686099">Newsletter Sign-Up</a> </div> </div> </main> <div data-global-resource-path="git/og-stage/templates/partials/footer.html"><footer class="website-footer flex flex-column g-20"> <div class="footer-columns"> <div class="footer-column"> <a href="https://oxfordglobal.com" class="site-logo-link"> <img src="https://oxfordglobal.com/wp-content/uploads/2023/03/Oxford-Global-Logo-Stacked-Websize.png" class="site-logo"> </a> </div> <div class="footer-column"> <h3>Brands</h3> <ul> <li> <a href="/precision-medicine/">Precision Medicine</a> </li> <li> <a href="/discovery-development/">Discovery & Development</a> </li> <li> <a href="/nextgen-biomed/">NextGen Biomed</a> </li> </ul> </div> <div class="footer-column"> <h3>Services</h3> <ul> <li> <a href="https://oxfordglobal.com/in-person-services/"> In-Person Services </a> </li> <li> <a href="https://oxfordglobal.com/digital-marketing-services/"> Digital Marketing Services </a> </li> </ul> <h3>Upcoming Events</h3> <ul> <li> <a href="https://oxfordglobal.com/calendar/"> Event Calendar </a> </li> </ul> </div> <div class="footer-column"> <h3>Company</h3> <ul> <li class="elementor-icon-list-item"> <a href="https://oxfordglobal.com/about-us/"> About </a> </li> <li class="elementor-icon-list-item"> <a href="https://oxfordglobal.com/vacancies/"> Vacancies </a> </li> <li class="elementor-icon-list-item"> <a href="https://oxfordglobal.com/csr-policy/"> CSR Policy </a> </li> <li class="elementor-icon-list-item"> <a href="javascript:postMessage({type:'HS_DISPLAY_CALL_TO_ACTION',id:130207947529});"> Contact </a> </li> </ul> </div> <div class="footer-column"> <p> <a href="tel:+441865248455">+44 1865 248 455</a><br> <a href="mailto:help@oxfordglobal.com">help@oxfordglobal.com</a> </p> <p> <strong>Our UK Address:</strong><br> Godstow Court<br> Minns Business Park<br> Botley<br> Oxford, OX2 0JB </p> <p> <strong>Our US Address:</strong><br> 100 Cambridge Street<br> 14th Floor<br> Boston<br> MA 02114 </p> </div> </div> <div class="footer-bottom grid g-20"> <div class="span8 span12-sm span12-md flex flex-column g-10"> <div class="copyright"> © Oxford Global Marketing Ltd. 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CAR T-REX Aims to Bolster Anti-Tumoural Immune Response