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mice</title> <meta name="description" content="Search results for: albino mice"> <meta name="keywords" content="albino mice"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" 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class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="albino mice"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 77</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: albino mice</h1> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">77</span> Effect of the Ethanolic Leaf Extract of Ficus exasperata on Biochemical Indices of Albino Mice Experimentally Infected with Plasmodium berghei (NK 65)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Lebari%20B.%20Gboeloh">Lebari B. Gboeloh </a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p><em>Ficus exasperata</em> is a plant used in the traditional management of malaria in south-south Nigeria. An investigation into the effects of the ethanolic extract of the leaf of the plant on some biochemical indices in albino mice infected with <em>Plasmodium berghei </em>(NK 65) was conducted. 48 mice with weight range of 13-23 g were grouped into six (A, B, C, D, E, and F). Each group contained 8 mice. Groups A, B, C, D and E were infected with blood containing the parasite. Group F was not infected and served as the normal control. On the 6<sup>th</sup> day after infection, 4 mice from each group were sacrificed and blood samples are collected for investigation. The remaining mice in each group were treated. Mice in Groups A, B and C were administered orally with 200, 300 and 500 mg/kg body weight of <em>Ficus exasperata</em> respectively for six days. Group D was not treated while Group F was given distilled water. Group E was treated with 5 mg/kg body weight of chloroquine. On the 6<sup>th</sup> day post treatment, these mice were sacrificed and blood samples were collected for biochemical analysis. The results indicated that on the 6<sup>th</sup> day post inoculation, the levels of aspartate aminotransferase (AST), alkaline phosphatase (ALP) and alanine aminotransferase (ALT) in all the mice infected with the parasite were significantly (p < 0.05) elevated. However, on the 6<sup>th</sup> day post administration of extract, the increased levels of AST, ALP and ALT were significantly (p < 0.05) reduced in groups administered with 300 and 500 mg/kg body weight of the extract compared with groups D and F. The reduction in the levels of these enzymes is an indication that <em>F. exasperata</em> have no hepatotoxic effect on the mice at the dose levels administered.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Ficus%20exasperata" title="Ficus exasperata">Ficus exasperata</a>, <a href="https://publications.waset.org/search?q=albino%20mice" title=" albino mice"> albino mice</a>, <a href="https://publications.waset.org/search?q=Plasmodium%20berghei" title=" Plasmodium berghei"> Plasmodium berghei</a>, <a href="https://publications.waset.org/search?q=biochemical%20parameters." title=" biochemical parameters. "> biochemical parameters. </a> </p> <a href="https://publications.waset.org/10006608/effect-of-the-ethanolic-leaf-extract-of-ficus-exasperata-on-biochemical-indices-of-albino-mice-experimentally-infected-with-plasmodium-berghei-nk-65" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10006608/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10006608/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10006608/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10006608/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10006608/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10006608/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10006608/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10006608/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10006608/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10006608/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10006608.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1023</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">76</span> Study Regarding Effect of Isolation on Social Behaviour in Mice</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Ritu%20Shitak">Ritu Shitak</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Humans are social mammals, of the primate order. Our biology, our behaviour and our pathologies are unique to us. In our desire to understand, reduce solitary confinement one source of information is the many reports of social isolation of other social mammals, especially primates. A behavioural study was conducted in the department of pharmacology at Indira Gandhi Medical College, Shimla in Himachalpradesh province in India using white albino mice. Different behavioural parameters were observed by using open field, tail suspension, tests for aggressive behaviour and social interactions and the effect of isolation was studied. The results were evaluated and the standard statistics were applied. The said study was done to establish facts that isolation itself impairs social behaviour and can lead to alcohol dependence as well as related drug dependence.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Albino%20Mice" title="Albino Mice">Albino Mice</a>, <a href="https://publications.waset.org/search?q=Drug%20Dependence" title=" Drug Dependence"> Drug Dependence</a>, <a href="https://publications.waset.org/search?q=Social%20isolation." title=" Social isolation."> Social isolation.</a> </p> <a href="https://publications.waset.org/10000931/study-regarding-effect-of-isolation-on-social-behaviour-in-mice" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10000931/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10000931/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10000931/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10000931/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10000931/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10000931/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10000931/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10000931/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10000931/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10000931/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10000931.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2171</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">75</span> Hepatotoxicity Induced by Arsenic Trioxide in Adult Mice and Their Progeny</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=H.%20Bouaziz">H. Bouaziz</a>, <a href="https://publications.waset.org/search?q=N.%20Soudania"> N. Soudania</a>, <a href="https://publications.waset.org/search?q=M.%20Essafia"> M. Essafia</a>, <a href="https://publications.waset.org/search?q=I.%20Ben%20Amara"> I. Ben Amara</a>, <a href="https://publications.waset.org/search?q=A.%20Hakim"> A. Hakim</a>, <a href="https://publications.waset.org/search?q=K.%20Jamoussi"> K. Jamoussi</a>, <a href="https://publications.waset.org/search?q=Km.%20Zeghal"> Km. Zeghal</a>, <a href="https://publications.waset.org/search?q=N.%20Zeghal"> N. Zeghal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>In this investigation, we have evaluated the effects of arsenic trioxide on hepatic function in pregnant and lactating Swiss albino mice and their suckling pups. Experiments were carried out on female mice given 175 ppm As2O3 in their drinking water from the 14th day of pregnancy until day 14 after delivery. Our results showed a significant decrease in plasma levels of total protein and albumin, cholesterol and triglyceride in As2O3 treated mice and their pups. The hyperbilirubinemia and the increased plasma total alkaline phosphatase activity suggested the presence of cholestasis. Transaminase activities as well as lactate deshydrogenase activity in plasma, known as biomarkers of hepatocellular injury, were elevated indicating hepatic cells’ damage after treatment with As2O3. Exposure to arsenic led to an increase of liver thiobarbituric acid reactive substances level along with a concomitant decrease in the activities of superoxide dismutase, catalase and glutathione peroxidase and in glutathione.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Antioxidant%20status" title="Antioxidant status">Antioxidant status</a>, <a href="https://publications.waset.org/search?q=arsenic%20trioxide" title=" arsenic trioxide"> arsenic trioxide</a>, <a href="https://publications.waset.org/search?q=hepatotoxicity" title=" hepatotoxicity"> hepatotoxicity</a>, <a href="https://publications.waset.org/search?q=mice" title=" mice"> mice</a>, <a href="https://publications.waset.org/search?q=oxidative%20stress." title=" oxidative stress."> oxidative stress.</a> </p> <a href="https://publications.waset.org/10000655/hepatotoxicity-induced-by-arsenic-trioxide-in-adult-mice-and-their-progeny" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10000655/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10000655/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10000655/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10000655/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10000655/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10000655/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10000655/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10000655/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10000655/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10000655/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10000655.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2364</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">74</span> Ameliorating Effects of Silver Nanoparticles Synthesized Using Chlorophytum borivillianum against Gamma Radiation Induced Oxidative Stress in Testis of Swiss Albino Mice</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Ruchi%20Vyas">Ruchi Vyas</a>, <a href="https://publications.waset.org/search?q=Sanjay%20Singh"> Sanjay Singh</a>, <a href="https://publications.waset.org/search?q=Rashmi%20Sisodia"> Rashmi Sisodia</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p><em>Chlorophytum borivillianum </em>root extract (CBE) was chosen as a reducing agent to fabricate silver nanoparticles with the aim of studying its radioprotective efficacy. The formation of synthesized nanoparticles was characterized by UV–visible analysis (UV–vis), Fourier transform infra-red (FT-IR), Transmission electron microscopy (TEM), Scanning electron microscope (SEM). TEM analysis showed particles size in the range of 20-30 nm. For this study, Swiss albino mice were selected from inbred colony and were divided into 4 groups: group I- control (irradiated-6 Gy), group II- normal (vehicle treated), group III- plant extract alone and group IV- CB-AgNPs (dose of 50 mg/kg body wt./day) administered orally for 7 consecutive days before irradiation to serve as experimental. CB-AgNPs pretreatment rendered significant increase in body weight and testes weight at various post irradiation intervals in comparison to irradiated group. Supplementation of CB-AgNPs reversed the adverse effects of gamma radiation on biochemical parameters as it notably ameliorated the elevation in lipid peroxidation and decline in glutathione concentration in testes. These observations indicate the radio-protective potential of CB-AgNPs in testicular constituents against gamma irradiation in mice.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Chlorophytum%20borivillianum" title="Chlorophytum borivillianum">Chlorophytum borivillianum</a>, <a href="https://publications.waset.org/search?q=gamma%20radiation" title=" gamma radiation"> gamma radiation</a>, <a href="https://publications.waset.org/search?q=radioprotective" title=" radioprotective"> radioprotective</a>, <a href="https://publications.waset.org/search?q=silver%20nanoparticles." title=" silver nanoparticles. "> silver nanoparticles. </a> </p> <a href="https://publications.waset.org/10011121/ameliorating-effects-of-silver-nanoparticles-synthesized-using-chlorophytum-borivillianum-against-gamma-radiation-induced-oxidative-stress-in-testis-of-swiss-albino-mice" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10011121/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10011121/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10011121/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10011121/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10011121/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10011121/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10011121/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10011121/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10011121/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10011121/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10011121.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">942</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">73</span> Inductions of CaC2 on Sperm Morphology and Viability of the Albino Mice (Mus musculus)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Dike%20H.%20Ogbuagu">Dike H. Ogbuagu</a>, <a href="https://publications.waset.org/search?q=Etsede%20J.%20Oritsematosan"> Etsede J. Oritsematosan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>This work investigated possible inductions of CaC<sub>2</sub>, often misused by fruit vendors to stimulate artificial ripening, on mammalian sperm morphology and viability. Thirty isogenic strains of male albino mice,<em> Mus musculus </em>(age≈ 8weeks; weight= 32.5<img height="15" src="file:///C:/Users/Merve/AppData/Local/Temp/msohtmlclip1/01/clip_image002.gif" width="9" />2.0g) were acclimatized (ambient temperature 28.0±1.0°C) for 2 weeks and fed standard growers mash and water <em>ad libutum.</em> They were later exposed to graded toxicant concentrations (w/w) of 2.5000, 1.2500, 0.6250, and 0.3125% in 4 cages. A control cage was also established. After 5 weeks, 3 animals from each cage were sacrificed by cervical dislocation and the cauda epididymis excised. Sperm morphology and viability were determined by microscopic procedures. The ANOVA, means plots, Student’s t-test and variation plots were used to analyze data. The common abnormalities observed included Double Head, Pin Head, Knobbed Head, No Tail and With Hook. The higher toxicant concentrations induced significantly lower body weights [F<sub>(829.899) </sub>藘 F<sub>crit(4.19)</sub>] and more abnormalities [F<sub>(26.52) </sub>藘 F<sub>crit(4.00)</sub>] at P藗0.05. Sperm cells in the control setup were significantly more viable than those in the 0.625% (t=0.005) and 2.500% toxicant doses (t=0.018) at the 95% confidence limit. CaC<sub>2 </sub>appeared to induced morphological abnormalities and reduced viability in sperm cells of<em> M. musculus.</em></p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Artificial%20ripening" title="Artificial ripening">Artificial ripening</a>, <a href="https://publications.waset.org/search?q=Calcium%20carbide" title=" Calcium carbide"> Calcium carbide</a>, <a href="https://publications.waset.org/search?q=fruit%20vendors" title=" fruit vendors"> fruit vendors</a>, <a href="https://publications.waset.org/search?q=sperm%20morphology" title=" sperm morphology"> sperm morphology</a>, <a href="https://publications.waset.org/search?q=sperm%20viability." title=" sperm viability."> sperm viability.</a> </p> <a href="https://publications.waset.org/10004136/inductions-of-cac2-on-sperm-morphology-and-viability-of-the-albino-mice-mus-musculus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10004136/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10004136/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10004136/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10004136/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10004136/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10004136/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10004136/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10004136/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10004136/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10004136/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10004136.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1396</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">72</span> Histopathological and Morphological Defects in the Mice Prenatally Exposed to Low EMF</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Y.%20Rosli">Y. Rosli</a>, <a href="https://publications.waset.org/search?q=A.%20Husna%20AH"> A. Husna AH</a>, <a href="https://publications.waset.org/search?q=M.%20Nurhayati"> M. Nurhayati</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This research was carried out to determine the possible effects of low electromagnetic field (EMF) exposure to the developing mice fetuses. Pregnant mice were exposed to EMF exposure at 0mT (sham) and 1.2 mT for six hours per session, carried out on gestation day 3, 6, 9, 12 and 15. Samples from the stillborn offspring were observed for morphological defects. The heart didn-t show progressive cellular damage, the lungs were congested and emphysemics. The bones were in advance stage of hypertrophy. Spectrums of morphological defects were observed over 70% of the surviving offspring. These results indicate that even at lower exposure to low EMF, is enough to induce morphological defects in prenatal mice. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=bone%20hypertrophy" title="bone hypertrophy">bone hypertrophy</a>, <a href="https://publications.waset.org/search?q=EMF" title=" EMF"> EMF</a>, <a href="https://publications.waset.org/search?q=low%20electromagnetic%20field." title=" low electromagnetic field."> low electromagnetic field.</a> </p> <a href="https://publications.waset.org/3551/histopathological-and-morphological-defects-in-the-mice-prenatally-exposed-to-low-emf" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/3551/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/3551/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/3551/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/3551/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/3551/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/3551/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/3551/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/3551/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/3551/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/3551/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/3551.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1615</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">71</span> Evaluation of the Laser and Partial Vibration Stimulation on Osteoporosis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Ji%20Hyung%20Park">Ji Hyung Park</a>, <a href="https://publications.waset.org/search?q=Dong-Hyun%20Seo"> Dong-Hyun Seo</a>, <a href="https://publications.waset.org/search?q=Young-Jin%20Jung"> Young-Jin Jung</a>, <a href="https://publications.waset.org/search?q=Han%20Sung%20Kim"> Han Sung Kim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>The aim of this study is to evaluate the effects of the laser and partial vibration stimulation on the mice tibia with morphological characteristics. Twenty female C57BL/6 mice (12 weeks old) were used for the experiment. The study was carried out on four groups of animals each consisting of five mice. Four groups of mice were ovariectomized. Animals were scanned at 0 and 2 weeks after ovariectomy by using micro computed tomography to estimate morphological characteristics of tibial trabecular bone. Morphological analysis showed that structural parameters of multi-stimuli group appear significantly better phase in BV/TV, BS/BV, Tb.Th, Tb.N, Tb.Sp, and Tb.pf than single stimulation groups. However, single stimulation groups didn’t show significant effect on tibia with Sham group. This study suggests that multi-stimuli may restrain the change as the degenerate phase on osteoporosis in the mice tibia.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Laser" title="Laser">Laser</a>, <a href="https://publications.waset.org/search?q=Partial%20Vibration" title=" Partial Vibration"> Partial Vibration</a>, <a href="https://publications.waset.org/search?q=Osteoporosis" title=" Osteoporosis"> Osteoporosis</a>, <a href="https://publications.waset.org/search?q=in%20vivo%0D%0Amicro-CT" title=" in vivo micro-CT"> in vivo micro-CT</a>, <a href="https://publications.waset.org/search?q=mice." title=" mice."> mice.</a> </p> <a href="https://publications.waset.org/10000632/evaluation-of-the-laser-and-partial-vibration-stimulation-on-osteoporosis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10000632/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10000632/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10000632/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10000632/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10000632/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10000632/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10000632/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10000632/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10000632/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10000632/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10000632.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1963</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">70</span> Herpes Simplex Virus Type I Infection of Mice Testis and Effect on Fertility</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Victor%20A.%20Naumenko">Victor A. Naumenko</a>, <a href="https://publications.waset.org/search?q=Yuriy%20A.%20Tyulenev"> Yuriy A. Tyulenev</a>, <a href="https://publications.waset.org/search?q=Alla%20A.%20Kushch"> Alla A. Kushch</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The objective of current issue was to develop a model of testicular herpes simplex virus (HSV) type I infection for assessment of viral effect on fertility. 56 male mice were inoculated intraperitoneally with different concentrations of HSV on 8 day post partum. It was revealed that the optimal dose was 100 plaque forming units per mice as it provided testicular infection in 100% of survivors. HSV proteins were detected both in somatic and germ cells (spermatogonia, spermatocytes, spermatides). Although DNA load in testis was descending from 3 to 28 days post infection only 12.5% of infected males had offspring after mating with uninfected females comparing to 87.5% in control (p=0.012). These results are the first direct evidence for HSV impact in male sterility. Prepuberal mice appeared to be a suitable model for investigation of pathogenesis of virus-associated fertility disorders. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Herpes%20simplex%20virus%20type%20I" title="Herpes simplex virus type I">Herpes simplex virus type I</a>, <a href="https://publications.waset.org/search?q=male%20fertility" title=" male fertility"> male fertility</a>, <a href="https://publications.waset.org/search?q=prepuberal%20mice" title=" prepuberal mice"> prepuberal mice</a>, <a href="https://publications.waset.org/search?q=spermatogenesis." title=" spermatogenesis."> spermatogenesis.</a> </p> <a href="https://publications.waset.org/1938/herpes-simplex-virus-type-i-infection-of-mice-testis-and-effect-on-fertility" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/1938/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/1938/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/1938/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/1938/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/1938/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/1938/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/1938/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/1938/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/1938/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/1938/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/1938.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1743</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">69</span> Cannabidiol Treatment Ameliorates Acetaminophen-Induced Hepatotoxicity in Mice</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Amr%20A.%20Fouad">Amr A. Fouad</a>, <a href="https://publications.waset.org/search?q=Waleed%20H.%20Albuali"> Waleed H. Albuali</a>, <a href="https://publications.waset.org/search?q=Iyad%20Jresat"> Iyad Jresat</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>The possible therapeutic effect of cannabidiol, the major non-psychotropic Cannabis constituent, was investigated against acute hepatotoxicity induced by a single oral dose of acetaminophen (500mg/kg) in mice. Cannabidiol (two intraperitoneal injections, 5mg/kg, each) was given 1 hour and 12 hours following acetaminophen administration. Acetaminophen administration caused significant elevations of serum alanine aminotransferase, and hepatic malondialdehyde, and nitric oxide levels, and a significant decrease in hepatic reduced glutathione. Cannabidiol significantly attenuated the deterioration in the measured biochemical parameters resulted from acetaminophen administration. Also, histopathological examination showed that cannabidiol markedly attenuated ameliorated acetaminophen-induced liver tissue damage. These results emphasize that cannabidiol represents a potential therapeutic option to protect against acetaminophen hepartotoxicity which is a common clinical problem.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=cannabidiol" title="cannabidiol">cannabidiol</a>, <a href="https://publications.waset.org/search?q=acetaminophen" title=" acetaminophen"> acetaminophen</a>, <a href="https://publications.waset.org/search?q=liver" title=" liver"> liver</a>, <a href="https://publications.waset.org/search?q=mice." title=" mice."> mice.</a> </p> <a href="https://publications.waset.org/10858/cannabidiol-treatment-ameliorates-acetaminophen-induced-hepatotoxicity-in-mice" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10858/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10858/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10858/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10858/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10858/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10858/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10858/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10858/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10858/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10858/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10858.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2868</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">68</span> Gonadotoxic and Cytotoxic Effect of Induced obesity via Monosodium Glutamate on Mus musculus Testis Cytoarchitecture and Sperm Parameter</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=I.%20Nur%20Hilwani">I. Nur Hilwani</a>, <a href="https://publications.waset.org/search?q=R.%20Nasibah"> R. Nasibah</a>, <a href="https://publications.waset.org/search?q=S.%20Nurdiana"> S. Nurdiana</a>, <a href="https://publications.waset.org/search?q=M.%20J.%20Norashirene"> M. J. Norashirene</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Impaired fertility may be the result of indirect consumption of anti-fertility agents through food. Monosodium glutamate (MSG) has been widely used as food additive, flavour enhancer and included in vaccines. This study focuses in determining the gonadotoxic and cytotoxic effect of MSG on selected sperm parameters such as sperm viability, sperm membrane integrity and testes cytoarchitecture of male mice via histological examination to determine its effect on spermatogenesis. Twenty-four Mus musculus were randomly divided into 4 groups and given intraperitoneal injections (IP) daily for 14 days of different MSG concentrations at 250, 500 and 1000mg/kg MSG to body weight to induce obesity. Saline was given to control group. Mice were sacrificed and analysis revealed abnormalities in values for sperm parameters and damages to testes cytoarchitecture of male mice. The results recorded decreased viability (p<0.05) and integrity of sperm membrane (p>0.05) with degenerative structures in seminiferous tubule of testes. The results indicated various implications of MSG on male mice reproductive system which has consequences in fertility potential.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Sperm%20parameter" title="Sperm parameter">Sperm parameter</a>, <a href="https://publications.waset.org/search?q=sperm%20viability" title=" sperm viability"> sperm viability</a>, <a href="https://publications.waset.org/search?q=sperm%20membrane%0D%0Aintegrity%20and%20testes%20histology." title=" sperm membrane integrity and testes histology."> sperm membrane integrity and testes histology.</a> </p> <a href="https://publications.waset.org/9999350/gonadotoxic-and-cytotoxic-effect-of-induced-obesity-via-monosodium-glutamate-on-mus-musculus-testis-cytoarchitecture-and-sperm-parameter" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/9999350/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/9999350/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/9999350/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/9999350/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/9999350/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/9999350/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/9999350/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/9999350/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/9999350/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/9999350/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/9999350.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2376</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">67</span> Investigation of Anti-diabetic and Hypocholesterolemic Potential of Psyllium Husk Fiber (Plantago psyllium) in Diabetic and Hypercholesterolemic Albino Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Ishtiaq%20Ahmed">Ishtiaq Ahmed</a>, <a href="https://publications.waset.org/search?q=Muhammad%20Naeem"> Muhammad Naeem</a>, <a href="https://publications.waset.org/search?q=Abdul%20Shakoor"> Abdul Shakoor</a>, <a href="https://publications.waset.org/search?q=Zaheer%20Ahmed"> Zaheer Ahmed</a>, <a href="https://publications.waset.org/search?q=Hafiz%20Muhammad%20Nasir%20Iqbal"> Hafiz Muhammad Nasir Iqbal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present study was conducted to observe the effect of Plantago psyllium on blood glucose and cholesterol levels in normal and alloxan induced diabetic rats. To investigate the effect of Plantago psyllium 40 rats were included in this study divided into four groups of ten rats in each group. One group A was normal, second group B was diabetic, third group C was non diabetic and hypercholesterolemic and fourth group D was diabetic and hypercholesterolemic. Two groups B and D were made diabetic by intraperitonial injection of alloxan dissolved in 1mL distilled water at a dose of 125mg/Kg of body weight. Two groups C and D were made hypercholesterolemic by oral administration of powder cholesterol (1g/Kg of body weight). The blood samples from all the rats were collected from coccygial vein on 1st day, then on 21st and 42nd day respectively. All the samples were analyzed for blood glucose and cholesterol level by using enzymatic kits. The blood glucose and cholesterol levels of treated groups of rats showed significant reduction after 7 weeks of treatment with Plantago psyllium. By statistical analysis of results it was found that Plantago psyllium has anti-diabetic and hypocholesterolemic activity in diabetic and hypercholesterolemic albino rats. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Albino%20rats" title="Albino rats">Albino rats</a>, <a href="https://publications.waset.org/search?q=alloxan" title=" alloxan"> alloxan</a>, <a href="https://publications.waset.org/search?q=Plantago%20psyllium" title=" Plantago psyllium"> Plantago psyllium</a>, <a href="https://publications.waset.org/search?q=statistical%20analysis" title="statistical analysis">statistical analysis</a> </p> <a href="https://publications.waset.org/13773/investigation-of-anti-diabetic-and-hypocholesterolemic-potential-of-psyllium-husk-fiber-plantago-psyllium-in-diabetic-and-hypercholesterolemic-albino-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/13773/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/13773/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/13773/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/13773/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/13773/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/13773/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/13773/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/13773/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/13773/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/13773/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/13773.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2164</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">66</span> Chitosan Nanoparticle as a Novel Delivery System for A/H1n1 Influenza Vaccine: Safe Property and Immunogenicity in Mice</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Nguyen%20Anh%20Dzung">Nguyen Anh Dzung</a>, <a href="https://publications.waset.org/search?q=Nguyen%20Thi%20Ngoc%20H%C3%A0"> Nguyen Thi Ngoc H脿</a>, <a href="https://publications.waset.org/search?q=Dang%20Thi%20Hong%20Van"> Dang Thi Hong Van</a>, <a href="https://publications.waset.org/search?q=Nguyen%20Thi%20Lan%20Phuong"> Nguyen Thi Lan Phuong</a>, <a href="https://publications.waset.org/search?q=Nguyen%20Thi%0D%0ANhu%20Quynh"> Nguyen Thi Nhu Quynh</a>, <a href="https://publications.waset.org/search?q=Dinh%20Minh%20Hiep"> Dinh Minh Hiep</a>, <a href="https://publications.waset.org/search?q=Le%20Van%20Hiep"> Le Van Hiep</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aims of this paper are to study the efficacy of chitosan nanoparticles in stimulating specific antibody against A/H1N1 influenza antigen in mice. Chitosan nanoparticles (CSN) were characterized by TEM. The results showed that the average size of CSN was from 80nm to 106nm. The efficacy of A/H1N1 influenza vaccine loaded on the surface of CSN showed that loading efficiency of A/H1N1 influenza antigen on CSN was from 93.75 to 100%. Safe property of the vaccine were tested. In 10 days post vaccination, group of CSN 30 kDa and 300 kDa loaded A/H1N1 influenza antigen were the rate of immune response on mice to be 100% (9/9) higher than Al(OH)3 and other adjuvant. 100% mice in the experiment of all groups had immune response in 20 days post vaccination. The results also showed that HI titer of the group using CSN 300 kDa as an adjuvant increased significantly up to 3971 HIU, over three-fold higher than the Al(OH)3 adjuvant, chitosan (CS), and one hundredfold than the A/H1N1 antigen only. Stability of the vaccine formulation was investigated. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Chitosan%20nanoparticles" title="Chitosan nanoparticles">Chitosan nanoparticles</a>, <a href="https://publications.waset.org/search?q=A%2FH1N1%20influenza%20antigen" title=" A/H1N1 influenza antigen"> A/H1N1 influenza antigen</a>, <a href="https://publications.waset.org/search?q=vaccine" title=" vaccine"> vaccine</a>, <a href="https://publications.waset.org/search?q=immunogenicity" title=" immunogenicity"> immunogenicity</a>, <a href="https://publications.waset.org/search?q=adjuvant" title=" adjuvant"> adjuvant</a>, <a href="https://publications.waset.org/search?q=antibody%20titer" title=" antibody titer"> antibody titer</a> </p> <a href="https://publications.waset.org/5089/chitosan-nanoparticle-as-a-novel-delivery-system-for-ah1n1-influenza-vaccine-safe-property-and-immunogenicity-in-mice" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/5089/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/5089/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/5089/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/5089/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/5089/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/5089/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/5089/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/5089/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/5089/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/5089/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/5089.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2488</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">65</span> Antinociceptive and Anti-inflammatory Effects of Hydroalcohol Extract of Vitex agnus castus Fruit</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=M.%20Ramezani">M. Ramezani</a>, <a href="https://publications.waset.org/search?q=Gh.%20Amin"> Gh. Amin</a>, <a href="https://publications.waset.org/search?q=E.%20Jalili"> E. Jalili</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In present study the effects of anti-inflammatory and antinociceptive of vitex hydro-alcoholic extract were evaluated on male mice. In inflammatory test mice were divided into 7 groups: first group was control. The second group, positive control group, received dexamethasone (15 mg/kg) and the other five groups received different doses of hydroalcohol extract of Vitex fruit (265, 365, 465, 565, and 665 mg/kg). The inflammation was caused by xylene-induced ear edema. Formalin test was used for evaluation of antinociceptive effect of extract. In this test, mice were divided into 7 groups: control, morphine (10mg/kg) as positive control group, and Vitex extract groups ((265, 365, 465, 565, and 665 mg/kg). All drugs were administered intrapritoneally, 30 min before each test. The data were analyzed using one-way ANOVA followed by Tukey-kramer multiple comparison test. Results have shown significant antiinflammatory effects of extract at all dosed as compared with control (P<0.05). In the first phase of formalin test (0-5 min) none doses of extract could inhibit acute pain, but in the second phase (15-30 min) chronic pain decreased at 265, 365, 465, and 565 mg/kg doses (P<0.05). The results of this research indicated that Vitex extract remarkably inhibited inflammation and second phase of nociception (inflammatory pain) and can be used for treatment of inflammatory diseases. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Anti-inflammatory" title="Anti-inflammatory">Anti-inflammatory</a>, <a href="https://publications.waset.org/search?q=Antinociceptive" title=" Antinociceptive"> Antinociceptive</a>, <a href="https://publications.waset.org/search?q=Mice" title=" Mice"> Mice</a>, <a href="https://publications.waset.org/search?q=Vitexagnus%20castus." title=" Vitexagnus castus."> Vitexagnus castus.</a> </p> <a href="https://publications.waset.org/6993/antinociceptive-and-anti-inflammatory-effects-of-hydroalcohol-extract-of-vitex-agnus-castus-fruit" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/6993/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/6993/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/6993/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/6993/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/6993/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/6993/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/6993/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/6993/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/6993/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/6993/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/6993.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2093</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">64</span> Bone Generation through Mechanical Loading</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=R.%20S.%20A.%20Nesbitt">R. S. A. Nesbitt</a>, <a href="https://publications.waset.org/search?q=J.%20Macione"> J. Macione</a>, <a href="https://publications.waset.org/search?q=A.%20Debroy"> A. Debroy</a>, <a href="https://publications.waset.org/search?q=S.%20P.%20Kotha"> S. P. Kotha</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Bones are dynamic and responsive organs, they regulate their strength and mass according to the loads which they are subjected. Because, the Wnt/尾-catenin pathway has profound effects on the regulation of bone mass, we hypothesized that mechanical loading of bone cells stimulates Wnt/尾-catenin signaling, which results in the generation of new bone mass. Mechanical loading triggers the secretion of the Wnt molecule, which after binding to transmembrane proteins, causes GSK-3尾 (Glycogen synthase kinase 3 beta) to cease the phosphorylation of 尾-catenin. 尾-catenin accumulation in the cytoplasm, followed by its transport into the nucleus, binding to transcription factors (TCF/LEF) that initiate transcription of genes related to bone formation. To test this hypothesis, we used TOPGAL (Tcf Optimal Promoter 尾-galactosidase) mice in an experiment in which cyclic loads were applied to the forearm. TOPGAL mice are reporters for cells effected by the Wnt/尾-catenin signaling pathway. TOPGAL mice are genetically engineered mice in which transcriptional activation of 尾- catenin, results in the production of an enzyme, 尾-galactosidase. The presence of this enzyme allows us to localize transcriptional activation of 尾-catenin to individual cells, thereby, allowing us to quantify the effects that mechanical loading has on the Wnt/尾-catenin pathway and new bone formation. The ulnae of loaded TOPGAL mice were excised and transverse slices along different parts of the ulnar shaft were assayed for the presence of 尾-galactosidase. Our results indicate that loading increases 尾-catenin transcriptional activity in regions where this pathway is already primed (i.e. where basal activity is already higher) in a load magnitude dependent manner. Further experiments are needed to determine the temporal and spatial activation of this signaling in relation to bone formation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Bone%20Resorption%20and%20Formation" title="Bone Resorption and Formation">Bone Resorption and Formation</a>, <a href="https://publications.waset.org/search?q=Mechanical%20Loading%20of%20Bone" title=" Mechanical Loading of Bone"> Mechanical Loading of Bone</a>, <a href="https://publications.waset.org/search?q=Wnt%20Signaling%20Pathway%20%26%20%CE%B2-catenin." title=" Wnt Signaling Pathway & 尾-catenin."> Wnt Signaling Pathway & 尾-catenin.</a> </p> <a href="https://publications.waset.org/761/bone-generation-through-mechanical-loading" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/761/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/761/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/761/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/761/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/761/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/761/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/761/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/761/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/761/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/761/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/761.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1482</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">63</span> Effect of Geum Kokanicum Total Extract on Induced Nociception and Inflammation in Male Mice</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=M.%20Ramezani">M. Ramezani</a>, <a href="https://publications.waset.org/search?q=S.%20Ghaderifard"> S. Ghaderifard</a>, <a href="https://publications.waset.org/search?q=HR.%20Monsef-Esfahani"> HR. Monsef-Esfahani</a>, <a href="https://publications.waset.org/search?q=S.%20Nasri"> S. Nasri</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of this study is evaluating the antinociceptive and anti-inflamatory activity of Geum kokanicum. After determination total extract LD50, different doses of extract were chosen for intrapritoneal injections. In inflammation test, male NMRI mice were divided into 6 groups: control (normal saline), positive control (Dexamethasone 15mg/kg), and total extract (0.025, 0.05, 0.1, and 0.2 gr/kg). The inflammation was produced by xyleneinduced edema. In order to evaluate the antinociceptive effect of total extract, formalin test was used. Mice were divided into 6 groups: control, positive control (morphine 10mg/kg), and 4 groups which received total extract. Then they received Formalin. The animals were observed for the reaction to pain. Data were analyzed using One-way ANOVA followed by Tukey-Kramer multiple comparison test. LD50 was 1 gr/kg. Data indicated that 0.5,0.1 and 0.2 gr/kg doses of total extract have particular antinociceptive and antiinflammatory effects in a comparison with control (P<0.001). The most effective dose was 0.2 gr/kg which did not show any significant difference in a comparison with positive control. Results indicated that total extract can inhibit nociception in the first and second phase. The antinociceptive effects in high doses are the same as morphine as a strong analgesic substance. TLC chromatography indicated presence of steroids and triterpenoids in this plant. The effects of extract may be related to presence of these compounds. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Anti-inflammatory" title="Anti-inflammatory">Anti-inflammatory</a>, <a href="https://publications.waset.org/search?q=Antinociceptive" title=" Antinociceptive"> Antinociceptive</a>, <a href="https://publications.waset.org/search?q=Geum%0Akokanicum" title=" Geum kokanicum"> Geum kokanicum</a>, <a href="https://publications.waset.org/search?q=Mice." title=" Mice."> Mice.</a> </p> <a href="https://publications.waset.org/7341/effect-of-geum-kokanicum-total-extract-on-induced-nociception-and-inflammation-in-male-mice" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/7341/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/7341/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/7341/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/7341/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/7341/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/7341/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/7341/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/7341/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/7341/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/7341/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/7341.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1751</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">62</span> Protective Effect of Saponin Extract from the Root of Garcinia kola (Bitter kola) against Paracetamol- Induced Hepatotoxicity in Albino Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Yemisi%20Rufina%20Alli%20Smith">Yemisi Rufina Alli Smith</a>, <a href="https://publications.waset.org/search?q=Isaac%20Gbadura%20Adanlawo"> Isaac Gbadura Adanlawo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Liver disorders are one of the major problems of the world. Despite its frequent occurrence, high morbidity and high mortality, its medical management is currently inadequate. This study was designed to evaluate the hepatoprotective effect of saponin extract of the root of Garcinia kola on the integrity of the liver of paracetamol induced wistar albino rats. Twenty five (25) male adult wistar albino rats were divided into five (5) groups. Group I was the Control group that received distilled water only, group II was the negative control that received 2 g/kg of paracetamol on the 13th day, and group III, IV and V were pre-treated with 100, 200 and 400mg/kg of the saponin extract before inducing the liver damage on the 13th day with 2 g/kg of paracetamol. Twenty four (24) h after administration, the rats were sacrificed and blood samples were collected. The serum Alanine Transaminase (ALT), Aspartate Transaminase (AST), Alkaline Phosphatase (ALP) activities, Bilirubin and conjugated bilirubin, glucose and protein concentrations were evaluated. The liver was fixed immediately in Formalin and was processed and stained in Haematoxylin and Eosin (H&E). Administration of saponin extract from the root of Garcinia kola significantly decreased paracetamol induced elevated enzymes in the test group. Also histological observations showed that saponin extract of the root of Garcinia kola exhibited a significant liver protection against the toxicant as evident by the cells trying to return to normal. Saponin extract from the root of Garcinia kola indicated a protection of structural integrity of the hepatocytic cell membrane and regeneration of the damaged liver.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Garcinia%20kola" title="Garcinia kola">Garcinia kola</a>, <a href="https://publications.waset.org/search?q=Hepatoprotective" title=" Hepatoprotective"> Hepatoprotective</a>, <a href="https://publications.waset.org/search?q=paracetamol" title=" paracetamol"> paracetamol</a>, <a href="https://publications.waset.org/search?q=Saponin." title=" Saponin."> Saponin.</a> </p> <a href="https://publications.waset.org/10000419/protective-effect-of-saponin-extract-from-the-root-of-garcinia-kola-bitter-kola-against-paracetamol-induced-hepatotoxicity-in-albino-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10000419/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10000419/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10000419/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10000419/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10000419/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10000419/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10000419/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10000419/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10000419/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10000419/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10000419.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2938</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">61</span> A Comparison on Healing Effects of an Ayurvedic Preparation and Silver Sulfadiazine on Burn Wounds in Albino Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=S.%20S.%20Pathak">S. S. Pathak</a>, <a href="https://publications.waset.org/search?q=M.%20A.%20Borkar"> M. A. Borkar</a>, <a href="https://publications.waset.org/search?q=S.%20S.%20Patel"> S. S. Patel</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>To compare Healing Effects of an Ayurvedic Preparation and Silver Sulfadiazine on burn wounds in Albino Rats. Methods: Albino rats– 30 male / female rats weighing between 150-200 g were used in the study. They were individually housed and maintained on normal diet and water ad libitum. Partial thickness burn wounds were inflicted, on overnight-starved animals under pentobarbitone (30mg/kg, i.p.) anaesthesia, by pouring hot molten wax at 80oC into a plastic cylinder of 300 mm2 circular openings placed on the shaven back of the animal. Apart from the drugs under investigation no local/ systemic chemotherapeutic cover will be provided to animals. All the animals were assessed for the percentage of wound contraction, signs of infection, scab formation and histopathological examination. Results: Percentage of wound healing was significantly better in the test ointment group compared to the standard. Signs of infection were observed in more animals in the test ointment group compared to the standard. Scab formation also took place earlier in the test ointment group compared to standard. Epithelial regeneration and healing profile was better in the test ointment compared to the standard. Moreover the test ointment group did not show any raised margins in the wound or blackish discoloration as was observed in silver sulfadiazine group. Conclusion: The burn wound healing effect of the ayurvedic ointment under study is better in comparison to standard therapy of silver sulfadiazine. The problem of infection encountered with the test ointment can be overcome by changing the concentrations and proportions of the ingredients in the test ointment which constitutes the further plan of the study.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Ayurvedic%20test%20ointment" title="Ayurvedic test ointment">Ayurvedic test ointment</a>, <a href="https://publications.waset.org/search?q=burn%20wounds" title=" burn wounds"> burn wounds</a>, <a href="https://publications.waset.org/search?q=Silver%0D%0Asulfadiazine." title=" Silver sulfadiazine."> Silver sulfadiazine.</a> </p> <a href="https://publications.waset.org/16160/a-comparison-on-healing-effects-of-an-ayurvedic-preparation-and-silver-sulfadiazine-on-burn-wounds-in-albino-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/16160/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/16160/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/16160/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/16160/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/16160/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/16160/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/16160/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/16160/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/16160/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/16160/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/16160.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2407</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">60</span> Detection of Oxidative Stress Induced by Mobile Phone Radiation in Tissues of Mice using 8-Oxo-7, 8-Dihydro-2'-Deoxyguanosine as a Biomarker</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Ahmad%20M.%20Khalil">Ahmad M. Khalil</a>, <a href="https://publications.waset.org/search?q=Ahmad%20M.%20Alshamali"> Ahmad M. Alshamali</a>, <a href="https://publications.waset.org/search?q=Marwan%20H.%20Gagaa"> Marwan H. Gagaa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We investigated oxidative DNA damage caused by radio frequency radiation using 8-oxo-7, 8-dihydro-2'- deoxyguanosine (8-oxodG) generated in mice tissues after exposure to 900 MHz mobile phone radio frequency in three independent experiments. The RF was generated by a Global System for Mobile Communication (GSM) signal generator. The radio frequency field was adjusted to 25 V/m. The whole body specific absorption rate (SAR) was 1.0 W/kg. Animals were exposed to this field for 30 min daily for 30 days. 24 h post-exposure, blood serum, brain and spleen were removed and DNA was isolated. Enzyme-linked immunosorbent assay (ELISA) was used to measure 8-oxodG concentration. All animals survived the whole experimental period. The body weight of animals did not change significantly at the end of the experiment. No statistically significant differences observed in the levels of oxidative stress. Our results are not in favor of the hypothesis that 900 MHz RF induces oxidative damage. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Mice" title="Mice">Mice</a>, <a href="https://publications.waset.org/search?q=Mobile%20phone%20radiation" title=" Mobile phone radiation"> Mobile phone radiation</a>, <a href="https://publications.waset.org/search?q=oxidative%20stress" title=" oxidative stress"> oxidative stress</a>, <a href="https://publications.waset.org/search?q=8-oxo-7" title=" 8-oxo-7"> 8-oxo-7</a>, <a href="https://publications.waset.org/search?q=8-dihydro-2%27-deoxyguanosine" title=" 8-dihydro-2'-deoxyguanosine"> 8-dihydro-2'-deoxyguanosine</a> </p> <a href="https://publications.waset.org/7054/detection-of-oxidative-stress-induced-by-mobile-phone-radiation-in-tissues-of-mice-using-8-oxo-7-8-dihydro-2-deoxyguanosine-as-a-biomarker" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/7054/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/7054/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/7054/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/7054/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/7054/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/7054/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/7054/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/7054/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/7054/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/7054/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/7054.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">2051</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">59</span> Cutaneous Application of Royal Jelly Inhibits Skin Lesions in NC/Nga Mice, a Human-Like Mouse Model of Atopic Dermatitis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Junki%20Miyamoto">Junki Miyamoto</a>, <a href="https://publications.waset.org/search?q=Mariko%20Kiyomi"> Mariko Kiyomi</a>, <a href="https://publications.waset.org/search?q=Yuuki%20Nagashio"> Yuuki Nagashio</a>, <a href="https://publications.waset.org/search?q=Takuya%20Suzuki"> Takuya Suzuki</a>, <a href="https://publications.waset.org/search?q=Soichi%20Tanabe"> Soichi Tanabe</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Anti-allergic effects of royal jelly were evaluated in a human-like mouse model of atopic dermatitis. NC/Nga mice were cutaneously applied with royal jelly for 6 weeks. Royal jelly-treated mice exhibited lower levels of serum total immunoglobulin E in comparison with controls. We found that the treatment decreased (11% to the control) expression of mRNA for aquaporin-3, which is involved in the modulation of epidermal hydration. Microarray analysis revealed more than 10-fold changes in the expression of several genes, such as transglutaminase 2, repetin, and keratins. In normal human epidermal keratinocytes, royal jelly extract suppressed interleukin-8 elevation induced by TNF-α and interferon-γ, suggesting direct anti-inflammatory activity in keratinocytes. Collectively, topical application of royal jelly may be useful for amelioration of lesions and inflammation in atopic dermatitis.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Aquaporin%203" title="Aquaporin 3">Aquaporin 3</a>, <a href="https://publications.waset.org/search?q=immunoglobulin%20E" title=" immunoglobulin E"> immunoglobulin E</a>, <a href="https://publications.waset.org/search?q=NC%2FNga" title=" NC/Nga"> NC/Nga</a>, <a href="https://publications.waset.org/search?q=royal%0D%0Ajelly." title=" royal jelly."> royal jelly.</a> </p> <a href="https://publications.waset.org/16309/cutaneous-application-of-royal-jelly-inhibits-skin-lesions-in-ncnga-mice-a-human-like-mouse-model-of-atopic-dermatitis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/16309/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/16309/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/16309/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/16309/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/16309/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/16309/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/16309/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/16309/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/16309/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/16309/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/16309.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1877</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">58</span> Effect of Retinoic Acid on Fetus Reproductive Organ Mice (Mus musculus) Swiss Webster</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Yulia%20Irnidayanti">Yulia Irnidayanti</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Retinoic acid is like a steroid hormone that plays a role in embryo formation, proliferation of spermatogonia cells, ephitelial cells differentiation and organogenesis. Retinoic acid can influences seminiferous tubule formation during embryonic testis development and also play a role in the regulation of ovarian function and female reproductive tract by suppressing the hormones FSH receptor expression. The excessive use of retinoic acid caused abnormalities in the fetus. The result showed that there is the influence of retinoic acid on the developmet of mice fetal testes, for examples disruption of the formation of seminiferous tubules and tubules seemed to be hollow, spermatogonia cells are relatively few in number and caused Leydig cells count relatively more. While in the female fetus does not caused the formation of primordial follicles and disrupted the development of germinal ephitelial cells of fetal ovaries of female mice (mus musculus) Swiss Webster. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Retinoic%20acid" title="Retinoic acid">Retinoic acid</a>, <a href="https://publications.waset.org/search?q=Leydig%20cell" title=" Leydig cell"> Leydig cell</a>, <a href="https://publications.waset.org/search?q=Spermatogonia%20cells" title=" Spermatogonia cells"> Spermatogonia cells</a>, <a href="https://publications.waset.org/search?q=Semin-%20ferous%20tubules" title=" Semin- ferous tubules"> Semin- ferous tubules</a>, <a href="https://publications.waset.org/search?q=Primordial%20follicles" title="Primordial follicles">Primordial follicles</a> </p> <a href="https://publications.waset.org/12680/effect-of-retinoic-acid-on-fetus-reproductive-organ-mice-mus-musculus-swiss-webster" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/12680/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/12680/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/12680/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/12680/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/12680/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/12680/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/12680/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/12680/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/12680/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/12680/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/12680.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1578</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">57</span> Efficacy of Combined CHAp and Lanthanum Carbonate in Therapy for Hyperphosphatemia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Andreea%20C%C3%A2r%C3%A2c">Andreea C芒r芒c</a>, <a href="https://publications.waset.org/search?q=Elena%20Moro%C5%9Fan"> Elena Moro艧an</a>, <a href="https://publications.waset.org/search?q=Ana%20Corina%20Ioni%C8%9B%C4%83"> Ana Corina Ioni葲膬</a>, <a href="https://publications.waset.org/search?q=Rica%20Boscencu"> Rica Boscencu</a>, <a href="https://publications.waset.org/search?q=Geta%20C%C3%A2r%C3%A2c"> Geta C芒r芒c</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Although, lanthanum carbonate has not been approved by the FDA for treatment of hyperphosphatemia, we prospectively evaluated the efficacy of the combination of Calcium hydroxyapatite (CHAp) and Lanthanum Carbonate (LaC) for the treatment of hyperphosphatemia on mice. CHAp was prepared by co-precipitation method using Ca(OH)2, H3PO4, NH4OH with calcination at 1200ºC. Lanthanum carbonate was prepared by chemical method using NaHCO3 and LaCl3 at low pH environment, below 4.0. The structures were characterized by FTIR spectra and SEM -EDX analysis. The study group included 16 subjects-mice divided into four groups according to the administered substance: lanthanum carbonate (group A), CHAp (group B), lanthanum carbonate + CHAp (group C) and salt water (group D). The results indicate a phosphate decrease when subjects (mice) were treated with CHAp and lanthanum carbonate (0.5% CMC), in a single dose of 1500 mg/kg. Serum phosphate concentration decreased [(from 4.5 ± 0.8 mg/dL) to 4.05 ± 0.2 mg/dL), P < 0.01] in group A and in group C (to 3.6 ± 0.2 mg/dL) at 12 hours from the administration. The combination of CHAp and lanthanum carbonate is a suitable regimen for hyperphosphatemia treatment because it avoids both the hypercalcemia of CaCO3 and the adverse effects of CHAp.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Calcium%20hydroxyapatite" title="Calcium hydroxyapatite">Calcium hydroxyapatite</a>, <a href="https://publications.waset.org/search?q=hyperphosphatemia" title=" hyperphosphatemia"> hyperphosphatemia</a>, <a href="https://publications.waset.org/search?q=lanthanum%20carbonate" title=" lanthanum carbonate"> lanthanum carbonate</a>, <a href="https://publications.waset.org/search?q=phosphatebinder" title=" phosphatebinder"> phosphatebinder</a>, <a href="https://publications.waset.org/search?q=structures." title=" structures."> structures.</a> </p> <a href="https://publications.waset.org/10001239/efficacy-of-combined-chap-and-lanthanum-carbonate-in-therapy-for-hyperphosphatemia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10001239/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10001239/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10001239/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10001239/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10001239/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10001239/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10001239/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10001239/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10001239/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10001239/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10001239.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1668</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">56</span> Antioxidant Responses to Different Exposure Regimes of Kazakhstan Light Crude Oil in Livers of Male Albino Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=K.%20Mahmoud">K. Mahmoud</a>, <a href="https://publications.waset.org/search?q=T.%20Shalahmetova"> T. Shalahmetova</a>, <a href="https://publications.waset.org/search?q=B.%20Umbayev"> B. Umbayev</a>, <a href="https://publications.waset.org/search?q=Sh.%20Deraz"> Sh. Deraz</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Biochemical investigations were carried out to assess the effect of different exposure regimes of Kazakhstan crude oil (KCO) on hepatic antioxidant defense system in albino rats. Contaminants were delivered under two different dosing regimes, with all treatments receiving the same total contaminant load by the end of the exposure period. Rats in regime A injected with KCO once at a dose of 6 ml/kg bw while in regime B injected multiply at a dose of 1.5 ml/kg bw on day 1, 3, 5 and 8. Antioxidant biomarkers were measured in hepatic tissue after 1, 3, 5 and 8 days. Significant induction was observed in serum aminotransferases (ALT, AST) (p<0.01) and hepatic Glutathione-S-transferase (GST) (p<0.05) in the two exposure regimes, with the majority of significant induction occurring in regime A. Superoxide dismutase (SOD) increased 1-d after injection (p<0.01) but the increase was reduced time dependently thereafter while after 8-d induced again (p<0.01). Malondialdehyde (MDA) significantly induced after 3 and 5-d (p<0.05) in regime A while in regime B was not changed significantly (p>0.05) at short time after exposure. However, there was significant increase after 8-d (p<0.01). Histological examination indicates that crude oil induced pathologic changes from inflammatory cells infiltration to hemorrhage and necrosis of hepatocytes. Acute exposure to crude oil adversely affect hepatic cell so human must avoid such exposure. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Kazakhstan%20crude%20oil" title="Kazakhstan crude oil">Kazakhstan crude oil</a>, <a href="https://publications.waset.org/search?q=Antioxidant%20biomarkers" title=" Antioxidant biomarkers"> Antioxidant biomarkers</a>, <a href="https://publications.waset.org/search?q=Histological%20examination" title="Histological examination">Histological examination</a>, <a href="https://publications.waset.org/search?q=Dose%20regime" title=" Dose regime"> Dose regime</a>, <a href="https://publications.waset.org/search?q=Rats" title=" Rats"> Rats</a> </p> <a href="https://publications.waset.org/3281/antioxidant-responses-to-different-exposure-regimes-of-kazakhstan-light-crude-oil-in-livers-of-male-albino-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/3281/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/3281/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/3281/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/3281/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/3281/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/3281/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/3281/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/3281/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/3281/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/3281/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/3281.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1966</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">55</span> Application of Staining Intensity Correlation Analysis to Visualize Protein Colocalizationat a Cellular Level</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Permphan%20Dharmasaroja">Permphan Dharmasaroja</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Mutations of the telomeric copy of the survival motor neuron 1 (SMN1) gene cause spinal muscular atrophy. A deletion of the Eef1a2 gene leads to lower motor neuron degeneration in wasted mice. Indirect evidences have been shown that the eEF1A protein family may interact with SMN, and our previous study showed that abnormalities of neuromuscular junctions in wasted mice were similar to those of Smn mutant mice. To determine potential colocalization between SMN and tissue-specific translation elongation factor 1A2 (eEF1A2), an immunochemical analysis of HeLa cells transfected with the plasmid pcDNA3.1(+)C-hEEF1A2- myc and a new quantitative test of colocalization by intensity correlation analysis (ICA) was used to explore the association of SMN and eEF1A2. Here the results showed that eEF1A2 redistributed from the cytoplasm to the nucleus in response to serum and epidermal growth factor. In the cytoplasm, compelling evidence showed that staining for myc-tagged eEF1A2 varied in synchrony with that for SMN, consistent with the formation of a SMN-eEF1A2 complex in the cytoplasm of HeLa cells. These findings suggest that eEF1A2 may colocalize with SMN in the cytoplasm and may be a component of the SMN complex. However, the limitation of the ICA method is an inability to resolve colocalization in components of small organelles such as the nucleus.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Intensity%20correlation%20analysis" title="Intensity correlation analysis">Intensity correlation analysis</a>, <a href="https://publications.waset.org/search?q=intensity%20correlation%20quotient." title=" intensity correlation quotient."> intensity correlation quotient.</a> </p> <a href="https://publications.waset.org/11815/application-of-staining-intensity-correlation-analysis-to-visualize-protein-colocalizationat-a-cellular-level" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/11815/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/11815/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/11815/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/11815/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/11815/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/11815/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/11815/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/11815/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/11815/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/11815/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/11815.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1504</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">54</span> Features of the Immune Response in Mice were Immunized with Polio Vaccine in Combination with Chitosan Preparations as Adjuvants</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Nelly%20%D0%9A.%20Akhmatova">Nelly 袣. Akhmatova</a>, <a href="https://publications.waset.org/search?q=%D0%9Elga%20V.%20Lebedinskaya"> 袨lga V. Lebedinskaya</a>, <a href="https://publications.waset.org/search?q=Stanislav%20G.%20Markushin"> Stanislav G. Markushin</a>, <a href="https://publications.waset.org/search?q=Elvin%20%D0%90.%20Akhmatov"> Elvin 袗. Akhmatov</a>, <a href="https://publications.waset.org/search?q=Lidiya%20A.%0D%0AGeiderova"> Lidiya A. Geiderova</a>, <a href="https://publications.waset.org/search?q=%D0%95lena%20%D0%90.%20Lebedinskaya"> 袝lena 袗. Lebedinskaya</a>, <a href="https://publications.waset.org/search?q=Vera%20M.%20Axenova"> Vera M. Axenova</a>, <a href="https://publications.waset.org/search?q=%D0%90natoliy%20P.%20Godovalov"> 袗natoliy P. Godovalov</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The study of cytokine expression in mice under the influence of inactivated poliovirus and Imovaks polio vaccine in combination with derivatives of chitosan shows various kinds of processes. There is a significant increase in IL-12 in the serum of immunized animals, which should stimulate the production of IFN-纬 NK-cells and T-cells and polarize the immune response to Th1 type. Thus, the derivatives of chitosan can promote cell component of the immune response, providing a full antiviral immunity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Poliovirus" title="Poliovirus">Poliovirus</a>, <a href="https://publications.waset.org/search?q=chitosan" title=" chitosan"> chitosan</a>, <a href="https://publications.waset.org/search?q=cytokine%20expression" title=" cytokine expression"> cytokine expression</a>, <a href="https://publications.waset.org/search?q=antiviral%20immunity." title=" antiviral immunity."> antiviral immunity.</a> </p> <a href="https://publications.waset.org/15227/features-of-the-immune-response-in-mice-were-immunized-with-polio-vaccine-in-combination-with-chitosan-preparations-as-adjuvants" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/15227/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/15227/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/15227/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/15227/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/15227/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/15227/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/15227/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/15227/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/15227/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/15227/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/15227.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1978</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">53</span> Proteomic Analysis of Tumor Tissue after Treatment with Ascorbic Acid</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Seyeon%20Park">Seyeon Park</a>, <a href="https://publications.waset.org/search?q=Mi%20Jang"> Mi Jang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tumor cells have an invasive and metastatic phenotype that is the main cause of death for cancer patients. Tumor establishment and penetration consists of a series of complex processes involving multiple changes in gene expression. In this study, intraperitoneal administration of a high concentration of ascorbic acid inhibited tumor establishment and decreased tumor mass in BALB/C mice implanted with S-180 sarcoma cancer cells. To identify proteins involved in the ascorbic acid-mediated inhibition of tumor progression, changes in the tumor proteome associated with ascorbic acid treatment of BALB/C mice implanted with S-180 were investigated using two-dimensional gel electrophoresis and mass spectrometry. Twenty protein spots were identified whose expression was different between control and ascorbic acid treatment groups. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Ascorbic%20acid" title="Ascorbic acid">Ascorbic acid</a>, <a href="https://publications.waset.org/search?q=Proteomic%20analysis" title=" Proteomic analysis"> Proteomic analysis</a>, <a href="https://publications.waset.org/search?q=S-180%20implantedBALB%2FC%20mouse" title=" S-180 implantedBALB/C mouse"> S-180 implantedBALB/C mouse</a> </p> <a href="https://publications.waset.org/13392/proteomic-analysis-of-tumor-tissue-after-treatment-with-ascorbic-acid" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/13392/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/13392/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/13392/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/13392/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/13392/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/13392/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/13392/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/13392/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/13392/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/13392/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/13392.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1679</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">52</span> Fatty Acid Extracts of Sea Pen (Virgularia gustaviana) and Their Potential Applications as Antibacterial, Antifungal, and Anti-Inflammatory Agents</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Sharareh%20Sharifi">Sharareh Sharifi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>In this study, the crude extracts of <em>Virgularia gustavina</em> were examined as antibacterial, antifungal and anti-inflammatory agent. To assess inflammation, Xylene was applied to the ear of mice. The mice of the experimental group were fed with doses of 10 mg/kg, 20 mg/kg, and 40 mg/kg of lipid extract of chloroform and hexane as a separate group and then statistical analysis was performed on the results. Chloroform and hexane extracts of sea pen have strong anti-inflammatory effects even at low doses which is probably due to 54% arachidonic acid. Antibacterial and antifungal effects of hexane and chloroform extracts were measured with MIC and MBC methods and it is shown that chloroform extract has best activity against <em>Staphylococcus</em> <em>aureus </em>on 125 µg/ml doze in MIC method.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Sea%20pen%20%28Virgularia%20gustaviana%29" title="Sea pen (Virgularia gustaviana)">Sea pen (Virgularia gustaviana)</a>, <a href="https://publications.waset.org/search?q=lipid%20extract" title=" lipid extract"> lipid extract</a>, <a href="https://publications.waset.org/search?q=anti-inflammatory" title=" anti-inflammatory"> anti-inflammatory</a>, <a href="https://publications.waset.org/search?q=antibacterial%20activity." title=" antibacterial activity."> antibacterial activity.</a> </p> <a href="https://publications.waset.org/10005579/fatty-acid-extracts-of-sea-pen-virgularia-gustaviana-and-their-potential-applications-as-antibacterial-antifungal-and-anti-inflammatory-agents" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10005579/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10005579/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10005579/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10005579/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10005579/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10005579/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10005579/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10005579/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10005579/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10005579/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10005579.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1246</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">51</span> The Effect of Aerobic Training and Taxol Consumption on IL 8 and PAI-1 in Cervical Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Alireza%20Barari">Alireza Barari</a>, <a href="https://publications.waset.org/search?q=Maryam%20Firoozi"> Maryam Firoozi</a>, <a href="https://publications.waset.org/search?q=Maryam%20Ebrahimzadeh"> Maryam Ebrahimzadeh</a>, <a href="https://publications.waset.org/search?q=Romina%20Roohani%20Ardeshiri"> Romina Roohani Ardeshiri</a>, <a href="https://publications.waset.org/search?q=Maryam%20Kamarloeei"> Maryam Kamarloeei</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Background: The purpose of this study was to analyze the effect of six-week aerobic training and taxol consumption on interleukin-8 and Plasminogen Activator Inhibitor-1 (PAI-1) in mice with cervical cancer. Materials and Methods: In this experimental study, 40 female C57 mice with cervical cancer, eight weeks old, were randomly divided into 4 groups including: control, taxol supplement, training, and training-taxol supplement. The implantation of cancerous tumors was performed under the skin at the upper of the pelvis. The program training was included: endurance training for six weeks, 3 sessions per week and 50 minutes per session, at the speed of 14-18 m/s. Taxol supplement at a dose of 60 mg/kg per day was injected intraperitoneally. Data analysis was performed using t-test and one-way ANOVA and if statistically significant, Bonferroni post hoc was used at the significance level p < .05. Results: The results showed that there was a significant difference between the levels of interleukin 8 (P < 0.05, F = 12.25) and the PAI-1 (P < 0.05, P = 0.10737 between the 4 groups. The results of this study showed a significant difference between the control group and the training - complementary group. Six weeks of aerobic training and taxol consumption have a significant effect on the level of PAI-1 and interleukin-8 mice with cervical cancer. Conclusion: Considering the effect of training on these variables, this type of exercise can be used as a complementary therapeutic approach with other therapies for cervical cancer.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Cervical%20cancer" title="Cervical cancer">Cervical cancer</a>, <a href="https://publications.waset.org/search?q=taxol" title=" taxol"> taxol</a>, <a href="https://publications.waset.org/search?q=endurance%20training" title=" endurance training"> endurance training</a>, <a href="https://publications.waset.org/search?q=interleukin%208" title=" interleukin 8"> interleukin 8</a>, <a href="https://publications.waset.org/search?q=plasminogen%20activator%20inhibitor-1." title=" plasminogen activator inhibitor-1."> plasminogen activator inhibitor-1.</a> </p> <a href="https://publications.waset.org/10013134/the-effect-of-aerobic-training-and-taxol-consumption-on-il-8-and-pai-1-in-cervical-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10013134/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10013134/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10013134/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10013134/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10013134/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10013134/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10013134/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10013134/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10013134/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10013134/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10013134.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">367</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">50</span> Anti-Diabetic Effect of Bryophyllum pinnatum Leaves </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=E.%20F.%20Aransiola">E. F. Aransiola</a>, <a href="https://publications.waset.org/search?q=M.O.%20Daramola"> M.O. Daramola</a>, <a href="https://publications.waset.org/search?q=E.%20O.%20Iwalewa"> E. O. Iwalewa</a>, <a href="https://publications.waset.org/search?q=A.%20M.%20Seluwa"> A. M. Seluwa</a>, <a href="https://publications.waset.org/search?q=O.%20O.%20Olufowobi"> O. O. Olufowobi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Diabetes is a chronic metabolic disorder that affects the quality of life in terms of physical health, social and psychological well-being. In spite of the enormous progress in the treatment of diabetes using existing commercial drugs, such as, insulin and oral hypoglycemic agents, the quest and search for new drugs is imperative due to several limitations of the commercial drugs. In addition, the existing diabetic drugs are expensive and unaffordable by the rural populace in the developing countries. The present study demonstrates the anti-diabetic property of aqueous extract of <em>Bryophyllum pinnatum</em> <em>(BP)</em> leaves using diabetic rats (albino rats) as models. At the same time, the anti-diabetic effect of the aqueous extract was compared to that of a sample containing a mixture of the extract and a commercial diabetic medicine, glibenclamide. A specified dosage of aqueous extract of <em>Bryophyllum pinnatum (BP)</em> leaves was administered on the experimental diabetic rats, and their BGL was measured and recorded. The results showed a significant drop in the BGL of the diabetic rats to a value close to normal blood glucose level within 120 minutes when only aqueous extract from <em>BP</em> leaves was used. When a sample containing a mixture of the aqueous extract and glibenclamide was administered, a further drop in BGL was observed. Therefore, the results reveal that aqueous extract of<em> Bryophyllum pinnatum</em> leaves have significant anti-diabetic properties, and that the performance of the existing drugs (glibenclamide) could be enhanced with the use of the aqueous extract.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Anti-diabetics" title="Anti-diabetics">Anti-diabetics</a>, <a href="https://publications.waset.org/search?q=Bryophyllum%20pinnatum" title=" Bryophyllum pinnatum"> Bryophyllum pinnatum</a>, <a href="https://publications.waset.org/search?q=Blood%20glucose%20level" title=" Blood glucose level"> Blood glucose level</a>, <a href="https://publications.waset.org/search?q=albino%20rats." title=" albino rats."> albino rats.</a> </p> <a href="https://publications.waset.org/9997719/anti-diabetic-effect-of-bryophyllum-pinnatum-leaves" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/9997719/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/9997719/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/9997719/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/9997719/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/9997719/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/9997719/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/9997719/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/9997719/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/9997719/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/9997719/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/9997719.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">5247</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">49</span> Origanum vulgare as a Possible Modulator of Testicular Endocrine Function in Mice </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Eva%20Tvrd%C3%A1">Eva Tvrd谩</a>, <a href="https://publications.waset.org/search?q=Barbora%20Babe%C4%8Dkov%C3%A1"> Barbora Babe膷kov谩</a>, <a href="https://publications.waset.org/search?q=Michal%20%C4%8Eura%C4%8Dka"> Michal 膸ura膷ka</a>, <a href="https://publications.waset.org/search?q=R%C3%B3bert%20Kirchner"> R贸bert Kirchner</a>, <a href="https://publications.waset.org/search?q=J%C3%BAlius%20%C3%81rvay"> J煤lius 脕rvay</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>This study was designed to assess the <em>in vitro</em> effects of <em>Origanum vulgare</em> L. (oregano) extract on the testicular steroidogenesis. We focused on identifying major biomolecules present in the oregano extract, as well as to investigate its <em>in vitro</em> impact on the secretion of cholesterol, testosterone, dehydroepiandrosterone and androstenedione by murine testicular fragments. The extract was subjected to high performance liquid chromatography (HPLC) which identified cyranosid, daidzein, thymol, rosmarinic and trans-caffeic acid among the predominant biochemical components of oregano. For the <em>in vitro</em> experiments, testicular fragments from 20 sexually mature Institute of Cancer Research (ICR) mice were incubated in the absence (control group) or presence of the oregano extract at selected concentrations (10, 100 and 1000 μg/mL) for 24 h. Cholesterol levels were quantified using photometry and the hormones were assessed by ELISA (Enzyme-Linked Immunosorbent Assay). Our data revealed that the release of cholesterol and androstenedione (but not dehydroepiandrosterone and testosterone) by the testicular fragments was significantly impacted by the oregano extract in a dose-dependent fashion. Supplementation of the extract resulted in a significant decline of cholesterol (P < 0.05 in case of 100 μg/mL; P < 0.01 with respect 100 μg/mL extract), as well as androstenedione (P < 0.01 with respect to 100 and 1000 μg/mL extract). Our results suggest that the biomolecules present in <em>Origanum vulgare</em> L. could exhibit a dose-dependent impact on the secretion of male steroids, playing a role in the regulation of testicular steroidogenesis.</p> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Mice" title="Mice">Mice</a>, <a href="https://publications.waset.org/search?q=Origanum%20vulgare%20L." title=" Origanum vulgare L."> Origanum vulgare L.</a>, <a href="https://publications.waset.org/search?q=steroidogenesis" title=" steroidogenesis"> steroidogenesis</a>, <a href="https://publications.waset.org/search?q=testes." title=" testes."> testes.</a> </p> <a href="https://publications.waset.org/10010785/origanum-vulgare-as-a-possible-modulator-of-testicular-endocrine-function-in-mice" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10010785/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10010785/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10010785/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10010785/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10010785/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10010785/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10010785/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10010785/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10010785/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10010785/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10010785.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1068</span> </span> </div> </div> <div class="card publication-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">48</span> Estimated Human Absorbed Dose of 111In-BPAMD as a New Bone-Seeking SPECT-Imaging Agent</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=H.%20Yousefnia">H. Yousefnia</a>, <a href="https://publications.waset.org/search?q=S.%20Zolghadri"> S. Zolghadri</a> </p> <p class="card-text"><strong>Abstract:</strong></p> An early diagnosis of bone metastasis is very important for making a right decision on a subsequent therapy. One of the most important steps to be taken initially, for developing a new radiopharmaceutical is the measurement of organ radiation exposure dose. In this study, the dosimetric studies of a novel agent for SPECT-imaging of the bone metastasis, 111In-(4- {[(bis(phosphonomethyl))carbamoyl]methyl}7,10bis(carboxymethyl) -1,4,7,10-tetraazacyclododec-1-yl) acetic acid (111In-BPAMD) complex, have been carried out to estimate the dose in human organs based on the data derived from mice. The radiolabeled complex was prepared with high radiochemical purity in the optimal conditions. Biodistribution studies of the complex was investigated in the male Syrian mice at the selected times after injection (2, 4, 24 and 48 h). The human absorbed dose estimation of the complex was made based on data derived from the mice by the radiation absorbed dose assessment resource (RADAR) method. 111In-BPAMD complex was prepared with high radiochemical purity >95% (ITLC) and specific activities of 2.85 TBq/mmol. Total body effective absorbed dose for 111In-BPAMD was 0.205 mSv/MBq. This value is comparable to the other 111In clinically used complexes. The results show that the dose with respect to the critical organs is satisfactory within the acceptable range for diagnostic nuclear medicine procedures. Generally, 111In-BPAMD has interesting characteristics and it can be considered as a viable agent for SPECT-imaging of the bone metastasis in the near future. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=In-111" title="In-111">In-111</a>, <a href="https://publications.waset.org/search?q=BPAMD" title=" BPAMD"> BPAMD</a>, <a href="https://publications.waset.org/search?q=absorbed%20dose" title=" absorbed dose"> absorbed dose</a>, <a href="https://publications.waset.org/search?q=RADAR." title=" RADAR."> RADAR.</a> </p> <a href="https://publications.waset.org/10002821/estimated-human-absorbed-dose-of-111in-bpamd-as-a-new-bone-seeking-spect-imaging-agent" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10002821/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10002821/bibtex" target="_blank" rel="nofollow" class="btn btn-primary 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