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style="background-image:url(https://ysm-res.cloudinary.com/image/upload/c_fill,f_auto,q_auto:eco,w_1400/v1/yms/prod/c70d2cee-054a-41dd-b4db-7ae6c9145405)"></div></div></section></section></div></div></div></div><main class="page-container" tabindex="-1" id="page-container"><div class="content content--home-page content--with-sidebar content--with-overlay page-with-overlay__content-container"><div class="component-wrapper component-wrapper--all"><section class="generic-content" aria-label="Yale University Reproductive Sciences Pregnancy Study (YURS-Pregnancy Study)"><div class="generic-content__title-container"><h1 class="generic-content__title">Yale University Reproductive Sciences Pregnancy Study (YURS-Pregnancy Study)</h1><div class="generic-content__subtitle">Principal Investigator: Dr. Michelle Silasi</div><ul class="share-panel share-panel--horizontal"><li class="share-panel__item"><button class="share-panel__link" aria-label="Share via X" type="button"><svg 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0l9.686-9.686a.5.5 0 0 0 .121-.511C22.58 4.03 22.274 4 22 4H2c-.275 0-.583.03-.691.359a.5.5 0 0 0 .121.511Z" style="fill:currentColor"></path></svg></button></li><li class="share-panel__item"><button type="button" aria-label="Print page" class="share-panel__button"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="share-panel__icon share-panel__print-icon"><path d="M5.25 17.249h-3a1.5 1.5 0 0 1-1.5-1.5v-7.5a1.5 1.5 0 0 1 1.5-1.5h19.5a1.5 1.5 0 0 1 1.5 1.5v7.5a1.5 1.5 0 0 1-1.5 1.5h-3" style="stroke-linecap:round;stroke-linejoin:round;fill:currentColor;stroke-width:.5px"></path><path d="M3.75 9.749h1.5" style="stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px;stroke-opacity:1"></path><path d="M5.25 12.749h13.5v10H5.25z" class="paper" style="stroke-linecap:round;stroke-linejoin:round;fill:currentColor;stroke-width:2"></path><path d="M18.75 6.749H5.25v-4.5a1.5 1.5 0 0 1 1.5-1.5h10.5a1.5 1.5 0 0 1 1.5 1.5Z" style="stroke-linecap:round;stroke-linejoin:round;fill:currentColor;stroke-width:.25px;stroke-opacity:1"></path></svg></button></li></ul></div><div><div class="generic-paragraph"><div class="heading__container"><h2 class="generic-paragraph__heading" id="our-mission">Our Mission</h2><div class="heading__anchor-copy-button-container"><button type="button" aria-label="Copy Link" class="anchor-copy-button anchor-copy-button--color-mode--dark"><span class="anchor-copy-button__content"><span class="anchor-copy-button__text">Copy Link</span><svg xmlns="http://www.w3.org/2000/svg" xml:space="preserve" viewBox="0 0 24 24" focusable="false" class="anchor-copy-button__icon"><path d="M5.253 21.497a5.21 5.21 0 0 1-3.712-1.535A5.21 5.21 0 0 1 .006 16.25c0-1.404.545-2.722 1.535-3.712l4.773-4.774a5.22 5.22 0 0 1 3.716-1.539c1.402 0 2.719.544 3.708 1.531a5.225 5.225 0 0 1 .538 6.804.75.75 0 0 1-1.048.165.74.74 0 0 1-.299-.489.75.75 0 0 1 .134-.558 3.73 3.73 0 0 0-.384-4.86 3.73 3.73 0 0 0-2.649-1.094 3.73 3.73 0 0 0-2.655 1.099l-4.774 4.774a3.754 3.754 0 0 0 0 5.303c.707.707 1.649 1.096 2.652 1.096s1.945-.389 2.652-1.096l.932-.932a.744.744 0 0 1 1.06 0 .744.744 0 0 1 0 1.06l-.932.932a5.2 5.2 0 0 1-3.712 1.537"></path><path d="M13.978 18.024a5.21 5.21 0 0 1-3.709-1.535 5.22 5.22 0 0 1-.536-6.803.75.75 0 0 1 1.047-.166.75.75 0 0 1 .3.49.75.75 0 0 1-.134.558 3.73 3.73 0 0 0 .383 4.859 3.73 3.73 0 0 0 2.65 1.096 3.73 3.73 0 0 0 2.654-1.1l4.773-4.773c.708-.708 1.098-1.65 1.098-2.652s-.39-1.943-1.098-2.652c-.707-.707-1.649-1.096-2.652-1.096s-1.945.389-2.652 1.096l-.75.75a.744.744 0 0 1-1.06 0c-.142-.141-.22-.33-.22-.53s.078-.389.22-.53l.75-.75c.99-.99 2.309-1.536 3.712-1.536s2.722.545 3.712 1.536a5.21 5.21 0 0 1 1.538 3.712 5.21 5.21 0 0 1-1.538 3.712l-4.773 4.773a5.21 5.21 0 0 1-3.711 1.54z"></path></svg></span></button></div></div><div class="generic-paragraph__text"><p>The goals of the YURS-Pregnancy Study are to create tools to help identify and prevent complications of pregnancy and improve birth outcomes for moms and babies. Over the next 5 years, we aim to include 1,000 families in this research project. The information and specimens generated from the YURS-Pregnancy Study will support many future research projects and become a resource for investigators, students, clinicians and patients. <br></p> <br> <p> <br> </p></div></div><div class="generic-paragraph"><div class="generic-paragraph__text">Think you'd like to participate in this project? <a href="mailto:%20lauren.perley@yale.edu">Click here to contact the study coordinator.</a><br></div><section aria-label="The Details" class="text-inset"><h2 class="text-inset__heading">The Details</h2><div class="text-inset__text"><p>The purpose of this study in pregnant women is to:</p> <ol> <li>Develop an integrated method of screening pregnancies to determine the risk of an adverse perinatal outcome.</li> <li>Identify novel genetic and molecular markers for adverse perinatal outcomes. We plan to recruit 1,000 women over the course of 5 years.</li> </ol> <p>The principal research question is to determine the ability of biochemical and ultrasonic markers to predict the likelihood of an adverse pregnancy outcome.. This project will lead to the eventual identification and development of new tests and tools to predict which women will have complicated pregnancies.</p> <p>This study follows a protocol very similar to one completed recently at the Department of Obstetrics and Gynecology of Cambridge University, UK. The level of similarity will allow us to combine data and samples and improve predictions of more rare but devastating outcomes which characterize adverse outcomes of pregnancy. </p> <p>Additionally, two similar studies could allow for external validation of identified findings and predictors. These biochemical and ultrasonic markers will then be used to predict the following adverse pregnancy outcomes:</p> <ol> <li>Pre-eclampsia (PE) </li> <li>Small for Gestational Age (SGA) </li> <li>Spontaneous preterm birth (SPTB) </li> <li>Stillbirth/Fetal Death </li> <li>Neonatal Death</li> </ol></div></section></div></div> </section></div><div class="component-wrapper component-wrapper--all"><section class="generic-content" aria-label="Contact Us"><div class="generic-content__title-container"><div class="heading__container"><h2 id="contact-us" class="generic-content__title">Contact Us</h2><div class="heading__anchor-copy-button-container"><button type="button" aria-label="Copy Link" class="anchor-copy-button anchor-copy-button--color-mode--dark"><span class="anchor-copy-button__content"><span class="anchor-copy-button__text">Copy Link</span><svg xmlns="http://www.w3.org/2000/svg" xml:space="preserve" viewBox="0 0 24 24" focusable="false" class="anchor-copy-button__icon"><path d="M5.253 21.497a5.21 5.21 0 0 1-3.712-1.535A5.21 5.21 0 0 1 .006 16.25c0-1.404.545-2.722 1.535-3.712l4.773-4.774a5.22 5.22 0 0 1 3.716-1.539c1.402 0 2.719.544 3.708 1.531a5.225 5.225 0 0 1 .538 6.804.75.75 0 0 1-1.048.165.74.74 0 0 1-.299-.489.75.75 0 0 1 .134-.558 3.73 3.73 0 0 0-.384-4.86 3.73 3.73 0 0 0-2.649-1.094 3.73 3.73 0 0 0-2.655 1.099l-4.774 4.774a3.754 3.754 0 0 0 0 5.303c.707.707 1.649 1.096 2.652 1.096s1.945-.389 2.652-1.096l.932-.932a.744.744 0 0 1 1.06 0 .744.744 0 0 1 0 1.06l-.932.932a5.2 5.2 0 0 1-3.712 1.537"></path><path d="M13.978 18.024a5.21 5.21 0 0 1-3.709-1.535 5.22 5.22 0 0 1-.536-6.803.75.75 0 0 1 1.047-.166.75.75 0 0 1 .3.49.75.75 0 0 1-.134.558 3.73 3.73 0 0 0 .383 4.859 3.73 3.73 0 0 0 2.65 1.096 3.73 3.73 0 0 0 2.654-1.1l4.773-4.773c.708-.708 1.098-1.65 1.098-2.652s-.39-1.943-1.098-2.652c-.707-.707-1.649-1.096-2.652-1.096s-1.945.389-2.652 1.096l-.75.75a.744.744 0 0 1-1.06 0c-.142-.141-.22-.33-.22-.53s.078-.389.22-.53l.75-.75c.99-.99 2.309-1.536 3.712-1.536s2.722.545 3.712 1.536a5.21 5.21 0 0 1 1.538 3.712 5.21 5.21 0 0 1-1.538 3.712l-4.773 4.773a5.21 5.21 0 0 1-3.711 1.54z"></path></svg></span></button></div></div></div><div><div class="generic-paragraph"><div class="generic-paragraph__text"><p>We would love to hear from you! </p> <p>Please email or call Lauren Perley </p> <p>YURS-Biobank & Pregnancy Study Manager <br></p> <p> <a href="mailto:%20lauren.perley@yale.edu">lauren.perley@yale.edu</a> <br> </p> <p>(203)-500-3995</p> (203)-737-6040</div></div></div> </section></div></div><div class="sidebar page__sidebar-container"><div class="sidebar__sticky-container"><div class="component-wrapper component-wrapper--all"><div><section aria-label="POPS" class="highlight-block highlight-block--background-mode--light highlight-block--outline-mode--dark highlight-block--size-mode--null"><div class="highlight-block-representation highlight-block-representation--size-mode--null"><a href="http://www.obgyn.cam.ac.uk/research/pops-2/" class="highlight-block-representation__link" aria-label="Read more about POPS" tabindex="-1"><figure class="highlight-block-figure highlight-block-figure--color-mode--coral highlight-block-figure--size-mode--null"><div class="highlight-block-figure__icon-wrapper"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="highlight-block-figure__icon"><circle cx="14.5" cy="18.75" r="1.5" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></circle><path d="M15.206 17.426 19 2.25M12.25 14.25h7.5M14.569.757a.373.373 0 0 1 .3.437M14.132 1.056a.373.373 0 0 1 .437-.3M14.431 1.494a.375.375 0 0 1-.3-.438M14.868 1.194a.375.375 0 0 1-.437.3M8.944 3.382a.375.375 0 0 1 .3.438M8.507 3.681a.375.375 0 0 1 .437-.3M8.806 4.119a.374.374 0 0 1-.3-.438M9.244 3.82a.376.376 0 0 1-.438.3M12.062 10.55a.375.375 0 0 1 .138.512M11.55 10.687a.376.376 0 0 1 .512-.137M11.687 11.2a.375.375 0 0 1-.137-.512" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path><path d="M12.2 11.062a.375.375 0 0 1-.513.137M5.5 10.5h2.25M5.5 18h2.25M5.5 14.25h2.25" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path><path d="M13.75 6.75h-9a.75.75 0 0 0-.624 1.166l1.248.895.126.245V21.75a1.5 1.5 0 0 0 1.5 1.5h11.25a1.5 1.5 0 0 0 1.5-1.5v-10.5" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></div></figure></a></div><div class="highlight-block-content highlight-block-content--size-mode--null"><div class="highlight-block-content__item"><a href="http://www.obgyn.cam.ac.uk/research/pops-2/" class="highlight-block-title__link" aria-label="Read more about POPS" tabindex="-1"><h2 class="LinesEllipsis text-overflow highlight-block-title highlight-block-title--type--main highlight-block-title--size-mode--null highlight-block-title--color-mode--blue">POPS<wbr/></h2></a></div><div class="highlight-block-content__item"><div class="LinesEllipsis text-overflow highlight-block-text"><div><p>Learn more about the study conducted in at the University of Cambridge by our partners and collaboratorsa</p></div></div></div><div class="highlight-block-content__item"></div></div></section></div></div></div></div></main><footer class="footer"><div class="footer__primary-panel-wrapper footer__primary-panel-wrapper--full-height"><div class="footer__content-container"><section class="footer__primary-panel" aria-label="Primary Links"><div class="desktop-footer-primary-panel"><div class="desktop-footer-primary-panel__organization-info-wrapper"><div class="footer-organization-info" role="presentation" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" aria-label="Yale School of Medicine" viewBox="0 0 384.2 29.1" focusable="false" class="site-wordmark__icon site-wordmark__icon--mode-ysm 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Over the next 5 years, we aim to include 1,000 families in this research project. The information and specimens generated from the YURS-Pregnancy Study will support many future research projects and become a resource for investigators, students, clinicians and patients.\r\n<br></p>\r\n<br>\r\n<p>\r\n <br>\r\n</p>","photo":null,"imageLink":null,"photoMode":"medium","photoAlignment":"right","textInset":{"heading":"","text":""}},{"heading":"","text":"Think you'd like to participate in this project? <a href=\"mailto:%20lauren.perley@yale.edu\">Click here to contact the study coordinator.</a><br>","photo":null,"imageLink":null,"photoMode":"medium","photoAlignment":"right","textInset":{"heading":"The Details","text":"<p>The purpose of this study in pregnant women is to:</p>\r\n<ol>\r\n <li>Develop an integrated method of screening pregnancies to determine the risk of an adverse perinatal outcome.</li>\r\n <li>Identify novel genetic and molecular markers for adverse perinatal outcomes. We plan to recruit 1,000 women over the course of 5 years.</li>\r\n</ol>\r\n<p>The principal research question is to determine the ability of biochemical and ultrasonic markers to predict the likelihood of an adverse pregnancy outcome.. This project will lead to the eventual identification and development of new tests and tools to predict which women will have complicated pregnancies.</p>\r\n<p>This study follows a protocol very similar to one completed recently at the Department of Obstetrics and Gynecology of Cambridge University, UK. The level of similarity will allow us to combine data and samples and improve predictions of more rare but devastating outcomes which characterize adverse outcomes of pregnancy. </p>\r\n<p>Additionally, two similar studies could allow for external validation of identified findings and predictors. These biochemical and ultrasonic markers will then be used to predict the following adverse pregnancy outcomes:</p>\r\n<ol>\r\n <li>Pre-eclampsia (PE) </li>\r\n <li>Small for Gestational Age (SGA) </li>\r\n <li>Spontaneous preterm birth (SPTB) </li>\r\n <li>Stillbirth/Fetal Death </li>\r\n <li>Neonatal Death</li>\r\n</ol>"}}],"relatedLinks":{"title":"Related Link","items":[],"columnsCount":1},"metaData":{"title":"Yale University Reproductive Sciences Pregnancy Study (YURS-Pregnancy Study)","description":"The goals of the YURS-Pregnancy Study are to create tools to help identify and prevent complications of pregnancy and improve birth outcomes for moms and babies. Over the next 5 years, we aim to include 1,000 families in this research project. The information and specimens generated from the YURS-Pregnancy Study will support many future research projects and become a resource for investigators, students, clinicians and patients.","imageMetaData":null,"videoMetaData":null,"audioMetaData":null,"author":null,"pageType":null,"publishDate":null,"canonicalUrl":null,"isNoIndex":false}}},{"key":"GenericContent","orderOnPage":3,"model":{"title":"Contact Us","subtitle":"","paragraphs":[{"heading":"","text":"<p>We would love to hear from you! </p>\r\n<p>Please email or call Lauren Perley </p>\r\n<p>YURS-Biobank &amp; Pregnancy Study Manager\r\n<br></p>\r\n<p>\r\n <a href=\"mailto:%20lauren.perley@yale.edu\">lauren.perley@yale.edu</a>\r\n <br>\r\n</p>\r\n<p>(203)-500-3995</p>\r\n(203)-737-6040","photo":null,"imageLink":null,"photoMode":"medium","photoAlignment":"right","textInset":{"heading":"","text":""}}],"relatedLinks":{"title":"Related Link","items":[],"columnsCount":1},"metaData":{"title":"Contact Us","description":"We would love to hear from you! Please email or call Lauren Perley YURS-Biobank & Pregnancy Study Manager lauren.perley@yale.edu (203)-500-3995(203)-737-6040","imageMetaData":null,"videoMetaData":null,"audioMetaData":null,"author":null,"pageType":null,"publishDate":null,"canonicalUrl":null,"isNoIndex":false}}}],"sidebarComponents":[{"key":"CtaBlock","orderOnPage":4,"model":{"title":"POPS","summary":"<p>Learn more about the study conducted in at the University of Cambridge by our partners and collaboratorsa</p>","url":"http://www.obgyn.cam.ac.uk/research/pops-2/","icon":{"iconName":"beaker","documentLinkType":null}}}],"contextNavigation":{"siteTitle":"Yale Reproductive Sciences Pregnancy Study","isTopLevelPage":true,"navigationItems":[{"link":{"isCurrentLink":false,"rootOrganizationPrefix":null,"currentLinkUrl":null,"url":"/obgyn/drs/yps/particiapte","text":"Participate"},"type":"pageLink","isActive":false,"isHomeLink":false},{"link":{"isCurrentLink":false,"rootOrganizationPrefix":null,"currentLinkUrl":null,"url":"/obgyn/drs/yps/opportunities","text":"Opportunities"},"type":"pageLink","isActive":false,"isHomeLink":false},{"link":{"isCurrentLink":false,"rootOrganizationPrefix":null,"currentLinkUrl":null,"url":"/obgyn/drs/yps/partners","text":"Partners"},"type":"pageLink","isActive":false,"isHomeLink":false},{"link":{"isCurrentLink":false,"rootOrganizationPrefix":null,"currentLinkUrl":null,"url":"/obgyn/drs/yps/people","text":"People"},"type":"pageLink","isActive":false,"isHomeLink":false}]}}</script> <script>window['applicationSettings'] = {"shouldShowSuppressedImageWarnings":false,"shouldShowBugReportButton":false,"shouldShowDownloadAsWordButton":false,"captchaKey":"a46dfca5-98da-4ec7-83e2-16980be648d0","facebookShareUrl":"https://www.facebook.com/dialog/share?app_id=604142276782606&display=popup&href=","isSearchFeedbackEnabled":true,"isSearchAnalyticsEnabled":true,"siteimproveScriptUrl":"https://siteimproveanalytics.com/js/siteanalyze_373.js","radarKey":"prj_live_pk_e9bc38cc9ac871b02332c0d599d7a893c03ad94d","mediaStatistics":{"baseUrl":"https://media-statistics-prod.ysmdevs.com","apiKey":"249c64e3-d0cc-45ed-97a0-5d3106411485","isEnabled":true}};</script> <noscript id="modern__LOADABLE_REQUIRED_CHUNKS__">[7651,7893,6602,1384,3053]</noscript><noscript id="modern__LOADABLE_REQUIRED_CHUNKS___ext">{"namedChunks":["modules-page-components-ComponentWrapper","features-banner-components-HomePageBanner","features-generic-content-components-GenericContent","features-cta-block-components-CtaBlock","modules-footer-components-Footer"]}</noscript> <script async data-chunk="main" src="https://cdn1.medicine.yale.edu/build/main.es2015.e71226adbc7ac9e6afaf.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="features-banner-components-HomePageBanner" src="https://cdn1.medicine.yale.edu/build/7651.es2015.5a5b8af729efc0360a32.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="features-banner-components-HomePageBanner" src="https://cdn1.medicine.yale.edu/build/7893.es2015.73040e9920f98448a728.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="features-generic-content-components-GenericContent" src="https://cdn1.medicine.yale.edu/build/6602.es2015.bd46f226efa281df2863.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="features-cta-block-components-CtaBlock" src="https://cdn1.medicine.yale.edu/build/1384.es2015.9e8de533c4560dbe1e68.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-footer-components-Footer" src="https://cdn1.medicine.yale.edu/build/3053.es2015.404cba0e717f410cb74c.js" type="module" crossorigin="anonymous"></script> <link rel="stylesheet" href="https://use.typekit.net/eqf4dwf.css" as="style" crossorigin>  <script async type="text/plain" data-cookiecategory="analytics" src="https://siteimproveanalytics.com/js/siteanalyze_373.js"></script> </body> </html>