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<!DOCTYPE html> <html> <head> <meta name="viewport" content="width=device-width,initial-scale=1.0"> <META NAME='keywords' CONTENT='Gary Bader, homepage, bioinformatics, computational biology, biological networks, pathways'><META NAME='description' CONTENT='Gary Bader c omputational biology lab homepage at the University of Toronto, Canada.'><meta http-equiv="Content-Type" content="text/html;charset=utf-8"> <meta name="robots" content="index,nofollow"> <title>Research - Bader Lab @ The University of Toronto</title> <script type="text/javascript" src="/moin_static198/common/js/common.js"></script> <script type="text/javascript">  </script> <link rel="stylesheet" type="text/css" media="all" href="/moin_static198/memodump/css/bootstrap.min.css"> <link rel="stylesheet" type="text/css" media="all" href="/moin_static198/memodump/css/bootstrap-theme.min.css"> <link rel="stylesheet" type="text/css" media="all" href="/moin_static198/memodump/css/memodump.css"> <link rel="stylesheet" type="text/css" media="all" href="/moin_static198/memodump/css/moinizer.css">   <link rel="alternate" title="Bader Lab @ The University of Toronto: Research" href="/Research?diffs=1&show_att=1&action=rss_rc&unique=0&page=Research&ddiffs=1" type="application/rss+xml"> <link rel="Start" href="/Home"> <link rel="Alternate" title="Wiki Markup" href="/Research?action=raw"> <link rel="Alternate" media="print" title="Print View" href="/Research?action=print"> <link rel="Appendix" title="2003_BaderHeilbutAndrewsTyersHughesBooneFunctionalGenomicsProteomicsReview.pdf" href="/Research?action=AttachFile&do=view&target=2003_BaderHeilbutAndrewsTyersHughesBooneFunctionalGenomicsProteomicsReview.pdf"> <link rel="Appendix" title="2004_GlobalMappingoftheYeastGeneticInteractionNetwork_TongEtAl_Science_Feb.pdf" href="/Research?action=AttachFile&do=view&target=2004_GlobalMappingoftheYeastGeneticInteractionNetwork_TongEtAl_Science_Feb.pdf"> <link rel="Appendix" title="2004_SGA_Hartwell_comment.pdf" href="/Research?action=AttachFile&do=view&target=2004_SGA_Hartwell_comment.pdf"> <link rel="Appendix" title="2005_PathwayInformationForSystemsBiology_Cary_Bader_Sander_FEBSLetters_Mar.pdf" href="/Research?action=AttachFile&do=view&target=2005_PathwayInformationForSystemsBiology_Cary_Bader_Sander_FEBSLetters_Mar.pdf"> <link rel="Appendix" title="2007_Cytoscape_Cline_NatureProtocols_Oct.pdf" href="/Research?action=AttachFile&do=view&target=2007_Cytoscape_Cline_NatureProtocols_Oct.pdf"> <link rel="Appendix" title="2008_Tonikian_PDZSpecificityMap_PlosBiology.pdf" href="/Research?action=AttachFile&do=view&target=2008_Tonikian_PDZSpecificityMap_PlosBiology.pdf"> <link rel="Appendix" title="Perspective_ScienceJan11_2002.pdf" href="/Research?action=AttachFile&do=view&target=Perspective_ScienceJan11_2002.pdf"> <link rel="Appendix" title="SGA_ScienceVol294-2001.pdf" href="/Research?action=AttachFile&do=view&target=SGA_ScienceVol294-2001.pdf"> <link rel="Appendix" title="SH3ScienceJan11_2002.pdf" href="/Research?action=AttachFile&do=view&target=SH3ScienceJan11_2002.pdf"> <link rel="Appendix" title="TravelAuthForm.pdf" href="/Research?action=AttachFile&do=view&target=TravelAuthForm.pdf"> <link rel="Search" href="/FindPage"> <link rel="Index" href="/TitleIndex"> <link rel="Glossary" href="/WordIndex"> <link rel="Help" href="/HelpOnFormatting"> <style type="text/css"> #turnkey-credit { font-family: Tahoma,Sans,Arial,Helvetica,Verdana,sans-serif; 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This map can then be read to understand how biological processes work, what is the function of a gene, and what effects disease-associated or engineered mutations have. Cell maps from different organisms or cell types can be compared to identify important components. Three research tracks and one software infrastructure track are actively developing to reach this goal. <span class="anchor" id="line-3"></span><span class="anchor" id="line-4"></span><p class="line874">General references: <span class="anchor" id="line-5"></span><span class="anchor" id="line-6"></span><ol type="1"><li><p class="line891"><strong>Functional Genomics and Proteomics: Charting a Multidimensional Map of the Cell</strong> <strong>Bader GD</strong>, Heilbut A, Andrews B, Tyers M, Hughes T, Boone C <a class="http" href="http://linkinghub.elsevier.com/retrieve/pii/S0962892403001272">Trends in Cell Biology Jul, 2003 13(7):344-56</a> - <a class="http" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12837605&dopt=Abstract">PubMed Abstract</a> - <a class="attachment" href="/Research?action=AttachFile&do=get&target=2003_BaderHeilbutAndrewsTyersHughesBooneFunctionalGenomicsProteomicsReview.pdf" title="PDF">PDF</a> <span class="anchor" id="line-7"></span></li><li><p class="line891"><strong>Pathway information for systems biology</strong> Cary MP, <strong>Bader GD</strong>, Sander C <a class="http" href="http://www.febsletters.org/retrieve/pii/S0014579305001705">FEBS Lett. 2005 Mar 21;579(8):1815-20</a> - <a class="http" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15763557&query_hl=14&itool=pubmed_docsum">PubMed Abstract</a> - <a class="attachment" href="/Research?action=AttachFile&do=get&target=2005_PathwayInformationForSystemsBiology_Cary_Bader_Sander_FEBSLetters_Mar.pdf" title="PDF">PDF</a> <span class="anchor" id="line-8"></span><span class="anchor" id="line-9"></span></li></ol><p class="line867"><div class="table-of-contents"><p class="table-of-contents-heading">Contents<ol><li> <a href="#Research_Tracks">Research Tracks</a><ol><li> <a href="#Genome_to_Network">Genome to Network</a></li><li> <a href="#Active_Cell_Map">Active Cell Map</a></li><li> <a href="#Multiple_Perturbation_Mapping">Multiple Perturbation Mapping</a></li></ol></li><li> <a href="#Software_Infrastructure_Track">Software Infrastructure Track</a><ol><li> <a href="#Pathway_Commons">Pathway Commons</a></li><li> <a href="#Cytoscape">Cytoscape</a></li><li> <a href="#GeneMANIA">GeneMANIA</a></li></ol></li></ol></div> <span class="anchor" id="line-10"></span><span class="anchor" id="line-11"></span><p class="line867"> <h1 id="Research_Tracks">Research Tracks</h1> <span class="anchor" id="line-12"></span><p class="line867"> <h2 id="Genome_to_Network">Genome to Network</h2> <span class="anchor" id="line-13"></span><p class="line874">We are developing computational methods to accurately predict the binding specificity of peptide recognition domains given the domain sequence and to predict biologically relevant protein-protein interactions given binding specificity. We are focusing on PDZ domains, recognizing hydrophobic C-termini, and WW and SH3 domains, recognizing proline rich motifs. Our questions are: <span class="anchor" id="line-14"></span><span class="anchor" id="line-15"></span><ul><li>Can we accurately predict biologically relevant interactions from a genome? <span class="anchor" id="line-16"></span></li><li>How do genome sequence changes affect the molecular network in the cell? <span class="anchor" id="line-17"></span></li><li>Can we predict how well model pathways or phenotypes will translate to human? <span class="anchor" id="line-18"></span></li><li>Can we design new networks de novo? <span class="anchor" id="line-19"></span><span class="anchor" id="line-20"></span></li></ul><p class="line867"><span class="anchor" id="line-21"></span><span class="anchor" id="line-22"></span><span class="anchor" id="line-23"></span><span class="anchor" id="line-24"></span><pre><span class="anchor" id="line-1"></span>Team: David Gfeller, Shirley Hui, Chris Tan, Shobhit Jain, Xioajian Shao <span class="anchor" id="line-2"></span>Collaborators: Sachdev Sidhu, Charlie Boone, Tony Pawson, Marius Sudol, Chris Sander, Philip Kim <span class="anchor" id="line-3"></span>Funding: CIHR</pre><span class="anchor" id="line-25"></span><p class="line874">References: <span class="anchor" id="line-26"></span><span class="anchor" id="line-27"></span><ol type="1"><li><p class="line891"><strong>A Specificity Map for the PDZ Domain Family.</strong> Raffi Tonikian, Yingnan Zhang, Stephen L. Sazinsky, Bridget Currell, Jung-Hua Yeh, Boris Reva, Heike A. Held, Brent A. Appleton, Marie Evangelista, Yan Wu, Xiaofeng Xin, Andrew C. Chan, Somasekar Seshagiri, Laurence A. Lasky, Chris Sander, Charles Boone, <strong>Gary D. Bader</strong>, Sachdev S. Sidhu <a class="http" href="http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0060239">PLoS Biology Vol. 6, No. 9, e239, 2008</a> - <a class="http" href="http://www.ncbi.nlm.nih.gov/pubmed/18828675">PubMed Abstract</a> - <a class="attachment" href="/Research?action=AttachFile&do=get&target=2008_Tonikian_PDZSpecificityMap_PlosBiology.pdf" title="PDF">PDF</a> <span class="anchor" id="line-28"></span></li><li><p class="line891"><strong>A Combined Experimental and Computational Strategy to Define Protein Interaction Networks for Peptide Recognition Modules</strong> Tong AH, Drees B, Nardelli G, <strong>Bader GD</strong>, Brannetti B, Castagnoli L, Evangelista M, Ferracuti S, Nelson B, Paoluzi S, Quondam M, Zucconi A, Hogue CW, Fields S, Boone C, Cesareni G <a class="http" href="http://www.sciencemag.org/cgi/content/abstract/295/5553/321">Science 2002 Jan 11;295(5553):321-324</a> - <a class="http" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11743162&dopt=Abstract">PubMed Abstract</a> - <a class="attachment" href="/Research?action=AttachFile&do=get&target=SH3ScienceJan11_2002.pdf" title="PDF">PDF</a> - <a class="attachment" href="/Research?action=AttachFile&do=get&target=Perspective_ScienceJan11_2002.pdf" title="Science Perspective PDF">Science Perspective PDF</a> <span class="anchor" id="line-29"></span><span class="anchor" id="line-30"></span></li></ol><p class="line867"> <h2 id="Active_Cell_Map">Active Cell Map</h2> <span class="anchor" id="line-31"></span><p class="line874">The 'active cell map' is the set of all interactions, complexes and pathways involving molecules in the cell and their activity under normal and diseased regulatory circumstances. We are developing novel computational methods to combine molecular network and profiles to uncover active cell map regions. Our questions are: <span class="anchor" id="line-32"></span><span class="anchor" id="line-33"></span><ul><li>What processes are active in a given tissue? <span class="anchor" id="line-34"></span></li><li>What processes are active in disease, but not in non-disease tissues? <span class="anchor" id="line-35"></span><span class="anchor" id="line-36"></span></li></ul><p class="line867"><span class="anchor" id="line-37"></span><span class="anchor" id="line-38"></span><span class="anchor" id="line-39"></span><span class="anchor" id="line-40"></span><pre><span class="anchor" id="line-1-1"></span>Team: Daniele Merico, Vuk Pavlovic, Ruth Isserlin, Oliver Stueker <span class="anchor" id="line-2-1"></span>Collaborators: Andrew Emili, Anthony Gramolini, Cynthia Guidos, Jayne Danska and others <span class="anchor" id="line-3-1"></span>Funding: CFI/MRI</pre><span class="anchor" id="line-41"></span><p class="line874">References: <span class="anchor" id="line-42"></span><span class="anchor" id="line-43"></span><p class="line867"><strong>Integration of biological networks and gene expression data using Cytoscape</strong> Cline MS, Smoot M, Cerami E, Kuchinsky A, Landys N, Workman C, Christmas R, Avila-Campilo I, Creech M, Gross B, Hanspers K, <strong>Isserlin R</strong>, Kelley R, Killcoyne S, Lotia S, Maere S, Morris J, Ono K, <strong>Pavlovic V</strong>, Pico AR, Vailaya A, Wang PL, Adler A, Conklin BR, Hood L, Kuiper M, Sander C, Schmulevich I, Schwikowski B, Warner GJ, Ideker T, <strong>Bader GD </strong><a class="http" href="http://www.nature.com/nprot/journal/v2/n10/abs/nprot.2007.324.html">Nature Protocols 2007;2(10):2366-82</a> - <a class="http" href="http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17947979">PubMed Abstract</a> - <a class="attachment" href="/Research?action=AttachFile&do=get&target=2007_Cytoscape_Cline_NatureProtocols_Oct.pdf" title="PDF">PDF</a> <span class="anchor" id="line-44"></span><span class="anchor" id="line-45"></span><p class="line867"> <h2 id="Multiple_Perturbation_Mapping">Multiple Perturbation Mapping</h2> <span class="anchor" id="line-46"></span><p class="line874">Buffering between biological processes, like the cell cycle and DNA damage repair systems, underlies cellular robustness to perturbations. Defects in one system affect dependent, but not buffered systems. Identifying these relationships is useful to delineate system boundaries in the cell. We aim to use quantitative genetic interactions to define pathways and complexes and infer their detailed buffering relationships. Our questions are: <span class="anchor" id="line-47"></span><span class="anchor" id="line-48"></span><ul><li>How are systems organized hierarchically within the cell? <span class="anchor" id="line-49"></span></li><li>How important is a set of genes for a biological system? <span class="anchor" id="line-50"></span><span class="anchor" id="line-51"></span></li></ul><p class="line867"><span class="anchor" id="line-52"></span><span class="anchor" id="line-53"></span><span class="anchor" id="line-54"></span><span class="anchor" id="line-55"></span><pre><span class="anchor" id="line-1-2"></span>Team: Anastasia Baryshnikova, Iain Wallace, Magali Michaut, Ron Ammar <span class="anchor" id="line-2-2"></span>Collaborators: Charlie Boone, Brenda Andrews, Guri Giaever, Corey Nislow <span class="anchor" id="line-3-2"></span>Funding: NSERC, Genome Canada Integrative Biology of Yeast</pre><span class="anchor" id="line-56"></span><p class="line874">References: <span class="anchor" id="line-57"></span><span class="anchor" id="line-58"></span><ol type="1"><li><p class="line891"><strong>Global Mapping of the Yeast Genetic Interaction Network</strong> Tong AH, Lesage G, <strong>Bader GD</strong>, Ding H, Xu H, Xin X, Young J, Berriz GF, Brost RL, Chang M, Chen Y, Cheng X, Chua G, Friesen H, Goldberg DS, Haynes J, Humphries C, He G, Hussein S, Ke L, Krogan N, Li Z, Levinson JN, Lu H, Menard P, Munyana C, Parsons AB, Ryan O, Tonikian R, Roberts T, Sdicu AM, Shapiro J, Sheikh B, Suter B, Wong SL, Zhang LV, Zhu H, Burd CG, Munro S, Sander C, Rine J, Greenblatt J, Peter M, Bretscher A, Bell G, Roth FP, Brown GW, Andrews B, Bussey H, Boone C <a class="http" href="http://www.sciencemag.org/cgi/content/full/303/5659/808">Science 2004 Feb 6;303(5659):808-813</a> - <a class="http" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14764870">PubMed Abstract</a> - <a class="attachment" href="/Research?action=AttachFile&do=get&target=2004_GlobalMappingoftheYeastGeneticInteractionNetwork_TongEtAl_Science_Feb.pdf" title="PDF">PDF</a> - <a class="attachment" href="/Research?action=AttachFile&do=get&target=2004_SGA_Hartwell_comment.pdf" title="Science Perspective PDF">Science Perspective PDF</a> <span class="anchor" id="line-59"></span></li><li><p class="line891"><strong>Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants</strong> Tong AH, Evangelista M, Parsons AB, Xu H, <strong>Bader GD</strong>, Page N, Robinson M, Raghibizadeh S, Hogue CW, Bussey H, Andrews B, Tyers M, Boone C <a class="http" href="http://www.sciencemag.org/cgi/content/abstract/294/5550/2364">Science 2001 Dec 14;294(5550):2364-8</a> - <a class="http" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11743205&dopt=Abstract">PubMed Abstract</a> - <a class="attachment" href="/Research?action=AttachFile&do=get&target=SGA_ScienceVol294-2001.pdf" title="PDF">PDF</a> <span class="anchor" id="line-60"></span><span class="anchor" id="line-61"></span></li></ol><p class="line867"> <h1 id="Software_Infrastructure_Track">Software Infrastructure Track</h1> <span class="anchor" id="line-62"></span><p class="line862">More details on the <a href="/Software">Software</a> page. <span class="anchor" id="line-63"></span><span class="anchor" id="line-64"></span><p class="line867"> <h2 id="Pathway_Commons">Pathway Commons</h2> <span class="anchor" id="line-65"></span><p class="line862">Pathway Commons is a collection of publicly available pathways from multiple organisms. It provides researchers with convenient access to a comprehensive collection of pathways from multiple sources represented in a common language (BioPAX). Pathways are stored in the cPath database software. URL: <a class="http" href="http://www.pathwaycommons.org">http://www.pathwaycommons.org</a> Pathway Commons is developed in collaboration with Chris Sander's group at MSKCC. <span class="anchor" id="line-66"></span><span class="anchor" id="line-67"></span><p class="line867"><span class="anchor" id="line-68"></span><span class="anchor" id="line-69"></span><span class="anchor" id="line-70"></span><span class="anchor" id="line-71"></span><pre><span class="anchor" id="line-1-3"></span>Team: Rashad Badrawi, Igor Rodchenkov <span class="anchor" id="line-2-3"></span>Collaborators: Chris Sander (MSKCC). Many additional Cytoscape, BioPAX and PSI-MI community members are important for this work. <span class="anchor" id="line-3-3"></span>Funding: NIH NHGRI, Genome Canada Technology Development</pre><span class="anchor" id="line-72"></span><span class="anchor" id="line-73"></span><p class="line867"> <h2 id="Cytoscape">Cytoscape</h2> <span class="anchor" id="line-74"></span><p class="line862">Cytoscape is an open source bioinformatics software platform for visualizing molecular interaction networks and integrating these interactions with gene expression profiles and other state data. URL: <a class="http" href="http://cytoscape.org/">http://cytoscape.org/</a> <span class="anchor" id="line-75"></span><span class="anchor" id="line-76"></span><p class="line867"><span class="anchor" id="line-77"></span><span class="anchor" id="line-78"></span><span class="anchor" id="line-79"></span><pre><span class="anchor" id="line-1-4"></span>Collaborators: Chris Sander (MSKCC), Trey Ideker (UCSD), Benno Schwikowski (Pasteur), David States (UMich), Annette Adler (Agilent), Yeyejide Adelye (Unilever), Bruce Conklin (UCSF), Lee Hood and Ilya Schmulevich (ISB). Many additional Cytoscape community members are important for this work. <span class="anchor" id="line-2-4"></span>Funding: NIH, Genome Canada Technology Development</pre><span class="anchor" id="line-80"></span><span class="anchor" id="line-81"></span><p class="line867"> <h2 id="GeneMANIA">GeneMANIA</h2> <span class="anchor" id="line-82"></span><p class="line862">GeneMANIA is a gene function prediction tool. Given a set of genes, the system finds additional similar genes based on a large amount of functional genomics data. URL: <a class="http" href="http://www.genemania.org/">http://www.genemania.org/</a> <span class="anchor" id="line-83"></span><span class="anchor" id="line-84"></span><p class="line867"><span class="anchor" id="line-85"></span><span class="anchor" id="line-86"></span><span class="anchor" id="line-87"></span><span class="anchor" id="line-88"></span><pre><span class="anchor" id="line-1-5"></span>Team: Rashad Badrawi, Ovi Comes, Sylva Donaldson, Farzana Kazi, Christian Lopes, Jason Montojo, Harold Rodriguez, Khalid Zuberi <span class="anchor" id="line-2-5"></span>Collaborators: Quaid Morris (UofT) <span class="anchor" id="line-3-4"></span>Funding: Genome Canada Technology Development, NIH NHGRI</pre><span class="anchor" id="line-89"></span><p class="line862">Full funding details at <a href="/Funding">Funding</a> <span class="anchor" id="line-90"></span><span class="anchor" id="bottom"></span></div>  <div class="clearfix"></div> </div>   </div>  </div>   <div id="pageinfo-container"> <div class="container"> <p id="pageinfo" class="info" lang="en" dir="ltr">Research (last edited 2010-02-14 20:45:57 by <span title="GaryBader @ CPE0024369ef1f2-CM0017ee54e5e8.cpe.net.cable.rogers.com[99.232.75.87]"><a href="/GaryBader" title="GaryBader @ CPE0024369ef1f2-CM0017ee54e5e8.cpe.net.cable.rogers.com[99.232.75.87]">GaryBader</a></span>)</p> </div> </div>   <div id="footer"> <div class="container text-right text-muted"> <ul id="credits"> <li><a href="http://moinmo.in/" title="This site uses the MoinMoin Wiki software.">MoinMoin Powered</a></li><li><a href="http://moinmo.in/Python" title="MoinMoin is written in Python.">Python Powered</a></li><li><a href="http://moinmo.in/GPL" title="MoinMoin is GPL licensed.">GPL licensed</a></li><li><a href="http://validator.w3.org/check?uri=referer" title="Click here to validate this page.">Valid HTML 4.01</a></li> </ul> <center><a href='http://host-tracker.com/' onMouseOver='this.href='http://host-tracker.com/website-uptime-statistics/474337/lvuc/';'><img width=80 height=15 border=0 alt='website tracker' src='http://ext.host-tracker.com/uptime-img/?s=15&t=474337&m=00.0&p=Total&src=lvuc'></a><noscript><a href='http://host-tracker.com/' >remote server monitor</a></noscript></center><script src='http://www.google-analytics.com/urchin.js' type='text/javascript'></script><script type='text/javascript'> _uacct = 'UA-387720-1';urchinTracker();</script> </div>  </div>     <script src="/moin_static198/memodump/js/jquery.min.js"></script>  <script src="/moin_static198/memodump/js/bootstrap.min.js"></script>  <script src="/moin_static198/memodump/js/toggle.js"></script>  <script> +function ($) { // Toggle minified navbar under mobile landscape view $('.navbar-collapse').on('show.bs.collapse', function () { $('.navbar-mobile-toggle').togglejs('show'); }); $('.navbar-collapse').on('hidden.bs.collapse', function () { $('.navbar-mobile-toggle').togglejs('hide'); }); //Scroll position fix for hash anchors var mdAnchorFix = { escapeRe: /[ !"#$%&'()*+,.\/:;<=>?@\[\\\]^`{|}~]/g, escape: function (str) { return str.replace(mdAnchorFix.escapeRe, '\\$&'); }, rgbRe: /^rgba$([ \t]*\d{1,3},){3}([ \t]*\d{1,3})$$/i, isTransparent: function (rgbstr) { if (rgbstr === 'transparent') { return true; } rgbMatch = rgbstr.match(mdAnchorFix.rgbRe); if (rgbMatch) { return (Number(rgbMatch[2]) ? false : true); } return false; }, navbarHeight: function () { var height = 0; var $navbar = $('.navbar'); if ( !mdAnchorFix.isTransparent($navbar.css('background-color')) && ($navbar.css('display') !== 'none') && ($navbar.css('visibility') !== 'hidden') ) { height = $navbar.height(); } return height; }, jump: function () { origin = $('#' + mdAnchorFix.escape(location.hash.substr(1))).offset().top; offset = mdAnchorFix.navbarHeight() + 15; setTimeout(function () { window.scrollTo(0, origin - offset); }, 1); }, clickWrapper: function () { if ( ($(this).attr('href') === location.hash) || !('onhashchange' in window.document.body) ) { setTimeout(function () { $(window).trigger("hashchange"); }, 1); } }, }; $('#pagebox a[href^="#"]:not([href="#"])').on("click", mdAnchorFix.clickWrapper); $(window).on("hashchange", mdAnchorFix.jump); if (location.hash) setTimeout(function () { mdAnchorFix.jump(); }, 100); }(jQuery); </script>  <div id="turnkey-credit"> <div style="clear: both;"> <a href="https://www.turnkeylinux.org/moinmoin">MoinMoin Appliance</a> - Powered by <a href="https://www.turnkeylinux.org">TurnKey Linux</a> </div> </div></body> </html>