RJPT - An Attempt to applying Hydrotropy Technique for Titrimetric estimation of Ketoprofen using Sodium salicylate as Hydrotrope

<!DOCTYPE html> <html> <head><meta charset="utf-8" /><meta http-equiv="X-UA-Compatible" content="IE=edge" />  <meta name="viewport" content="width=device-width, initial-scale=1" />  <title> RJPT - An Attempt to applying Hydrotropy Technique for Titrimetric estimation of Ketoprofen using Sodium salicylate as Hydrotrope </title><link href="css1/bootstrap.min.css" rel="stylesheet" />  <link href="fonts/css/font-awesome.min.css" rel="stylesheet" />  <link href="https://fonts.googleapis.com/css?family=Lato:400,300,400italic,700,900,700italic" rel="stylesheet" type="text/css" /><link href="https://fonts.googleapis.com/css?family=Roboto:500" rel="stylesheet" type="text/css" />  <link rel="stylesheet" href="css1/slicknav.css" />  <link href="rs-plugin/css/settings.css" rel="stylesheet" />  <link href="css1/owl.carousel.css" rel="stylesheet" />  <link href="style.css" rel="stylesheet" />  <link href="css1/responsive.css" rel="stylesheet" /><meta name="msapplication-TileColor" content="#ffffff" /><meta name="msapplication-TileImage" content="f_icon/ms-icon-144x144.png" /><meta name="theme-color" content="#ffffff" /> <script type="text/javascript" src="https://d3mkw6s8thqya7.cloudfront.net/integration-plugin.js" id="aisensy-wa-widget" widget-id="XFmHWJ" > </script> <meta name="Description" content="Ketoprofen used as a Non-steroidal anti-inflammatory drug selected as a poorly water-soluble model drug. Due to the poorly soluble nature of Ketoprofen liberate reduced bioavailability. Hydrotropic solubilization technique is a promising technique used to improve the solubility of water-insoluble drugs. In this investigation, 2M sodium salicylate has been employed in the titrimetric estimation of Ketoprofen and shows synergistic enhancement in the solubility of Ketoprofen by many folds as compared to the distilled water. It excluded the use of various organic solvent like ethanol; methanol and chloroform widely utilized in the titrimetric estimation of various poorly soluble drugs but due to the higher cost, volatility, toxicities lead to environmental pollution hence are the cons of it. The proposed method is new, simple, precise, and inexpensive. The results of the analysis have been validated statistically. The mean % recoveries were found to be close to 100, indicating the accuracy of the proposed method. Low values of standard deviation, % coefficient of variation, and standard error further proved the reproducibility and precision of the proposed method." /><meta http-equiv="Content-Type" content="text/html; charset=utf-8" /><meta name="citation_title" content="An Attempt to applying Hydrotropy Technique for Titrimetric estimation of Ketoprofen using Sodium salicylate as Hydrotrope" /><meta name="citation_author" content="Devika Tripathi" /><meta name="citation_author" content="Nandini Chaudhary" /><meta name="citation_author" content="Dinesh Kumar Sharma" /><meta name="citation_author" content="Jagannath Sahoo" /><meta name="citation_publication_date" content="2021/04/29" /><meta name="citation_date" content="2021/04/29" /><meta name="citation_journal_title" content="Research Journal of Pharmacy and Technology" /><meta name="citation_volume" content="14" /><meta name="citation_issue" content="4" /><meta name="citation_firstpage" content="2277" /><meta name="citation_lastpage" content="2279" /><meta name="citation_abstract_pdf_url" content="https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-78" /><meta name="citation_html_url" content="https://rjptonline.org/HTMLPaper.aspx?Journal=Research Journal of Pharmacy and Technology;PID=2021-14-4-78" /><meta name="citation_abstract_html_url" content="https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-78" /><meta name="citation_publisher" content="Research Journal of Pharmacy and Technology" /><meta name="citation_issn_print" content="0974-3618" /><meta name="citation_issn_online" content="0974-360X" /><meta name="citation_language" content="English" /><meta name="citation_keywords" content="Hydrotropy; Titrimetric analysis; Ketoprofen; Sodium salicylate; Solubility enhancement ; anti-inflammatory; bioavailability; solubilization; water-insoluble; reproducibility" /><meta name="citation_doi" content="10.52711/0974-360X.2021.00402" /></head> <body> <form method="post" 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" 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</div> </div> <div class="col-md-2 col-lg-2 col-sm-12 col-xs-12"> <div class="opening_time s_header"> <p class="uppercase" style="color: #1a00cc; font-size: 14px; font-weight: bold">ISSN</p> <p style="color: #1a00cc; line-height: 21px"> 0974-360X (Online) <br /> 0974-3618 (Print) </p> </div> </div> </div> </div> <br /> </div> </div>   <section class="slider_area"> <div class="mainmenu_area"> <div class="container"> <div class="row"> <div class="col-md-10 col-lg-10"> <div class="mainmenu nav"> <nav> <ul id="nav"> <li class="current"><a href="Home.aspx">Home <i class="fa fa-angle-down"></i></a> <ul> <li><a href="AboutJournal.aspx">About Journal</a></li> <li><a href="Indexed_In.aspx">Indexing Information</a></li> <li><a href="ContactUs.aspx">Raise Query</a></li> </ul> </li> <li><a href="PastIssues.aspx">Past Issues</a></li> <li><a href="EditorialBoard.aspx">Editorial Board</a></li> <li><a href="#">For Authors <i class="fa fa-angle-down"></i></a> <ul> <li><a 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class="request_code"> <a href="SubmitArticle.aspx">Submit Article</a> </div> </div> </div> </div> </div> </section>  <div class="container"> <div class="col-md-9 col-lg-9 col-sm-12 col-xs-12"> <section class="blog_area section_padding"> <div class="row"> <div class="Abstract_page_title text-center"> <h1> <span id="ContentPlaceHolder1_PaperTitle" style="font-weight:bold;"><a href='AbstractView.aspx?PID=2021-14-4-78' class='myLink'>An Attempt to applying Hydrotropy Technique for Titrimetric estimation of Ketoprofen using Sodium salicylate as Hydrotrope</a><a href='https://scholar.google.co.in/scholar?q=An Attempt to applying Hydrotropy Technique for Titrimetric estimation of Ketoprofen using Sodium salicylate as Hydrotrope' target='_blank' style='color:blue'> <img src='Images/GoogleScholar.png' style='height:23px'></a></span> </h1> </div> <div class="single_blog"> <div style="background: #f6f6f6 none repeat scroll 0 0; padding: 8px; border-left: 4px solid #11c3f1"> <p style="text-align: left; font-size: 14px"> <span style="color: rgba(193, 4, 4, 0.76)">Author(s):</span> <span id="ContentPlaceHolder1_AuthorName"><a href='search.aspx?key=Devika Tripathi' >Devika Tripathi</a>, <a href='search.aspx?key=Nandini Chaudhary' >Nandini Chaudhary</a>, <a href='search.aspx?key=Dinesh Kumar Sharma' >Dinesh Kumar Sharma</a>, <a href='search.aspx?key=Jagannath Sahoo' >Jagannath Sahoo</a></span> </p> <p style="text-align: left; font-size: 14px"> <span style="color: rgba(193, 4, 4, 0.76)">Email(s):</span> <span id="ContentPlaceHolder1_AuthorEmail"><a href='mailto:tripd990@gmail.com' target='_blank' >tripd990@gmail.com</a> </span> </p> <p style="text-align: left; font-size: 14px;"> <span style="color: rgba(193, 4, 4, 0.76)">DOI:</span> <span id="ContentPlaceHolder1_DOI_No" style="font-weight:normal;"><a href='https://doi.org/10.52711/0974-360X.2021.00402' target='_blank' style='color:blue'>10.52711/0974-360X.2021.00402</a>    <a href='https://scholar.google.co.in/scholar?q=10.52711/0974-360X.2021.00402' target='_blank' style='color:blue'> <img src='Images/GoogleScholar.png' style='height:25px'></a></span> </p> <p style="text-align: left; font-size: 14px"> <span style="color: rgba(193, 4, 4, 0.76)">Address:</span> <span id="ContentPlaceHolder1_AuthorAddress">Devika Tripathi1*, Nandini Chaudhary1, Dinesh Kumar Sharma2, Jagannath Sahoo3<br> 1Pharmacy Department, Pranveer Singh Institute of Technology, Kanpur, India.<br> 2Pharmacy Department, Himalayan Institute of Pharmacy Dehradun, Uttarakhand, India.<br> 3Pharmacy Department, Krishna Institute of Engineering and Technology, Ghaziabad, India.<br> *Corresponding Author</span> </p> <p style="text-align: left; font-size: 13px; margin-top: 5px"> <span style="color: rgba(193, 4, 4, 0.76)">Published In:</span>   <a href="Issues.aspx?VID=14&IID=4" id="ContentPlaceHolder1_Vol_Issue_link" style="font-weight:bold">Volume - <span id="ContentPlaceHolder1_VOL_no" style="font-weight:normal;">14</span>,      Issue - <span id="ContentPlaceHolder1_ISSUE_no" style="font-weight:normal;">4</span>,     Year - <span id="ContentPlaceHolder1_Pub_Year" style="font-weight:normal;">2021</span> </a> </p> <div class="clearfix"></div> <div style="float:right;"> <span id="ContentPlaceHolder1_Cite_icon_lbl" style="font-weight:normal;"><script async src='https://badge.dimensions.ai/badge.js' charset='utf-8'></script> <span class='__dimensions_badge_embed__' data-doi='10.52711/0974-360X.2021.00402' data-style='small_circle'></span> <div class='clearfix'></div></span> </div> <div class="blog_page" style="padding: 10px; margin-bottom: 28px"> <a href="HTMLPaper.aspx?Journal=Research Journal of Pharmacy and Technology;PID=2021-14-4-78" id="ContentPlaceHolder1_HTML_View_lnk" class="top_quate_action2 float_Right"> <img src="Images/html.png" />  View HTML</a>      <a id="ContentPlaceHolder1_PDF_View_lnk" class="top_quate_action2 float_Right" href="javascript:__doPostBack('ctl00$ContentPlaceHolder1$PDF_View_lnk','')"><img src="Images/pdf.png" style="height:28px" />   View PDF</a> </div> <div class="clearfix"></div> </div> <div class="blog_content blog_page"> <br /> <p style="text-align: justify"> <span style="color: black; font-weight: bold">ABSTRACT:</span> <br /> <span id="ContentPlaceHolder1_Abstract" style="color:Black;">Ketoprofen used as a Non-steroidal anti-inflammatory drug selected as a poorly water-soluble model drug. Due to the poorly soluble nature of Ketoprofen liberate reduced bioavailability. Hydrotropic solubilization technique is a promising technique used to improve the solubility of water-insoluble drugs. In this investigation, 2M sodium salicylate has been employed in the titrimetric estimation of Ketoprofen and shows synergistic enhancement in the solubility of Ketoprofen by many folds as compared to the distilled water. It excluded the use of various organic solvent like ethanol; methanol and chloroform widely utilized in the titrimetric estimation of various poorly soluble drugs but due to the higher cost, volatility, toxicities lead to environmental pollution hence are the cons of it. The proposed method is new, simple, precise, and inexpensive. The results of the analysis have been validated statistically. The mean % recoveries were found to be close to 100, indicating the accuracy of the proposed method. Low values of standard deviation, % coefficient of variation, and standard error further proved the reproducibility and precision of the proposed method.</span> </p> <br /> <div class="tags"> <i class="text-left" style="color:black; font-size: 13px; font-weight: normal">Keywords:</i> <span id="ContentPlaceHolder1_Key_words" style="font-size:Smaller;"><ul class='text-left'><li><a href=''Hydrotropy' target='_blank' >Hydrotropy</a></li><li><a href=''Titrimetric analysis' target='_blank' >Titrimetric analysis</a></li><li><a href=''Ketoprofen' target='_blank' >Ketoprofen</a></li><li><a href=''Sodium salicylate' target='_blank' >Sodium salicylate</a></li><li><a href=''Solubility enhancement.' target='_blank' >Solubility enhancement.</a></li></ul></span> </div> </div> <div class="highlight_text"> <img src="img/hilight.png" alt=""> <p> <span style="color: rgba(193, 4, 4, 0.76)">Cite this article:</span> <br /> <span id="ContentPlaceHolder1_Cite">Devika Tripathi, Nandini Chaudhary, Dinesh Kumar Sharma, Jagannath Sahoo. An Attempt to applying Hydrotropy Technique for Titrimetric estimation of Ketoprofen using Sodium salicylate as Hydrotrope. Research Journal of Pharmacy and Technology. 2021; 14(4):2277-9. doi: 10.52711/0974-360X.2021.00402</span> <br /><br /> <span style="color: rgba(193, 4, 4, 0.76)">Cite(Electronic):</span> <br> <span id="ContentPlaceHolder1_Cite1">Devika Tripathi, Nandini Chaudhary, Dinesh Kumar Sharma, Jagannath Sahoo. An Attempt to applying Hydrotropy Technique for Titrimetric estimation of Ketoprofen using Sodium salicylate as Hydrotrope. Research Journal of Pharmacy and Technology. 2021; 14(4):2277-9. doi: 10.52711/0974-360X.2021.00402   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-4-78</span> </p> </div> <div class="clearfix"></div> <br /> <span id="ContentPlaceHolder1_Additional_Information_lbl"><div><b>REFERENCE:</b></div><div>1.<span style="white-space:pre"> </span>Maheshwari RK. 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Pharmazie. 1990; 45: 221-225.</div><div>21.<span style="white-space:pre"> </span>Maheshwari RK. Novel application of hydrotropic solubilization in the Spectrophotometric analysis Ofiroxicam in the solid dosage form. Indian Drug. 2006; 43(8): 683-685.</div><div>22.<span style="white-space:pre"> </span>Maheshwari RK. Mixed hydrotropy in Spectrophotometric analysis of Aceclofenac. The Indian Pharmacist. 2007;6(64): 67-69</div><div>23.<span style="white-space:pre"> </span>Maheshwari RK, Arif D, Mittal P, Manchandani P, Indurkhya A, Jawade S. A novel method for the Quantitative Determination of Aceclofenac in bulk drug and tablets using Ibuprofen Sodium as a Hydrotropic Solubilizing agent. Journal of Applied Chemical and Research. 2008; 5: 63-68.</div><div>24.<span style="white-space:pre"> </span>Maheshwari RK, Patidar V, Maliwal D, Jain, A. Simultaneous Spectrophotometric estimation of Metronidazole and Norfloxacin in combined tablet formulations using hydrotropy. 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Hydrotropic solubilization in Spectrophotometric analysis of Cefixime in a solid dosage form. Asian Journal of Chemistry. 2008; 20(1): 375-379.</div><div>29.<span style="white-space:pre"> </span>Maheshwari RK, Deswal S, Tiwari D, Ali N, Pothen, B, Jain, S. Novel Spectrophotometric Estimation of Furosemide using hydrotropic Solubilization phenomenon. Indian Journal of Pharmaceutical Science. 2007; 69(6): 822-826.</div><div>30.<span style="white-space:pre"> </span>Maheshwari RK., Singh M. Quantitative determination of Ketoprofen bulk drug-using sodium salt of aspirin as a hydrotropic solubilizing agent. Asian Journal of Chemistry. 2008; 20(6): 4922- 4924.</div><div>31.<span style="white-space:pre"> </span>Maheshwari RK, Shukla RS. Quantitative Spectrophotometric estimation of Famotidine using hydrotropic solubilization Technique. Asian Journal of Chemistry. 2008; 20(6): 4221-4224.</div><div>32.<span style="white-space:pre"> </span>Darwish A, Florence AT, Saleh AM. Effects of hydrotropic agents on the Solubility, Precipitation, and protein binding of Etoposide. Journal of Pharmaceutical Science. 1989; 78: 577- 581.</div></span> <div class="clearfix"></div> <div class="abstractImage"> <div class="col-md-4"> <a id="ContentPlaceHolder1_ArticleImageLink1" target="_blank"> <img id="ContentPlaceHolder1_ArticleImage1" src="" /> </a> </div> <div class="col-md-4"> <a id="ContentPlaceHolder1_ArticleImageLink2" target="_blank"> <img id="ContentPlaceHolder1_ArticleImage2" src="" /> </a> </div> <div class="col-md-4"> <a id="ContentPlaceHolder1_ArticleImageLink3" target="_blank"> <img id="ContentPlaceHolder1_ArticleImage3" src="" /> </a> </div> </div> </div> </div> </section> <section class="blog_area section_padding"> <div class="row"> <div class="col-md-12 col-lg-12"> <div class="page_title" style="margin-bottom: 10px; border-bottom: 1px dashed #aeaeae"> <h2 class="head1">Recomonded Articles:</h2> </div> </div> </div> <div class="row"> </div> </section> </div> <div class="col-lg-3 col-md-3 col-sm-12 col-xs-12"> <section class="blog_area section_padding"> <div style="font-weight: bold; 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