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Djebar</title> <meta name="description" content="Search results for: R. Djebar"> <meta name="keywords" content="R. Djebar"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="R. 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Djebar"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 16</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: R. Djebar</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">16</span> Nanoparticles on Biological Biomarquers Models: Paramecium Tetraurelia and Helix aspersa</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=H.%20Djebar">H. Djebar</a>, <a href="https://publications.waset.org/abstracts/search?q=L.%20Khene"> L. Khene</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Boucenna"> M. Boucenna</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20R.%20Djebar"> M. R. Djebar</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20N.%20Khebbeb"> M. N. Khebbeb</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Djekoun"> M. Djekoun</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Currently in toxicology, use of alternative models permits to understand the mechanisms of toxicity at different levels of cells. Objectives of our research concern the determination of NPs ZnO, TiO2, AlO2, and FeO2 effect on ciliate protist freshwater Paramecium sp and Helix aspersa. The result obtained show that NPs increased antioxidative enzyme activity like catalase, glutathione –S-transferase and level GSH. Also, cells treated with high concentrations of NPs showed a high level of MDA. In conclusion, observations from growth and enzymatic parameters suggest on one hand that treatment with NPs provokes an oxidative stress and on the other that snale and paramecium are excellent alternatives models for ecotoxicological studies. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=NPs" title="NPs">NPs</a>, <a href="https://publications.waset.org/abstracts/search?q=GST" title=" GST"> GST</a>, <a href="https://publications.waset.org/abstracts/search?q=catalase" title=" catalase"> catalase</a>, <a href="https://publications.waset.org/abstracts/search?q=GSH" title=" GSH"> GSH</a>, <a href="https://publications.waset.org/abstracts/search?q=MDA" title=" MDA"> MDA</a>, <a href="https://publications.waset.org/abstracts/search?q=toxicity" title=" toxicity"> toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=snale%20and%20paramecium" title=" snale and paramecium"> snale and paramecium</a> </p> <a href="https://publications.waset.org/abstracts/49322/nanoparticles-on-biological-biomarquers-models-paramecium-tetraurelia-and-helix-aspersa" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/49322.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">281</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">15</span> Study of Toxic Effect and Anti-Oxidative Activity of a β- Amidophosphonates</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Houria%20Djebar">Houria Djebar</a>, <a href="https://publications.waset.org/abstracts/search?q=Amina%20Saib"> Amina Saib</a>, <a href="https://publications.waset.org/abstracts/search?q=Malika%20Berredjem"> Malika Berredjem</a>, <a href="https://publications.waset.org/abstracts/search?q=Khaoula%20Bechlem"> Khaoula Bechlem</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammed-Reda%20Djebar"> Mohammed-Reda Djebar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Reactive oxygen species (ROS) have a high potential to damage almost all types of cellular components of the body, which explains their involvement in the induction and/or amplification of several pathologies. Supplementation of the body by exogenous antioxidants is very useful against these harmful species. In this context, we attempted to evaluate the in vitro and in vivo antioxidant activities of three newly synthesized amidophosphonates (AP1, AP2, and AP3). The results relating to the in vitro tests for DPPH radical scavenging activity shows that these amidophosphonates have a modest antiradical power (ARP) less effectively pronounced compared with an analogue marketed in Algeria: (Dursban) Clorpiryphos ethyl. However, in vivo effects were evaluated on some antioxidant systems (LP intensity, CAT activity and GSH content), or in combination with 2, 2-diphenyl-picrylhydrazyle (DPPH) radical in paramecium tetraurelia used as a complementary system to rapidly elucidate the cytotoxicity. On the basis of the results obtained it can be concluded that amidophosphonates studied exhibited a mild protective effect. The mechanism for how they influenced the antioxidant activities was discussed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Paramecium%20tetraurelia" title="Paramecium tetraurelia">Paramecium tetraurelia</a>, <a href="https://publications.waset.org/abstracts/search?q=amidophosphonates" title=" amidophosphonates"> amidophosphonates</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20activity" title=" antioxidant activity"> antioxidant activity</a>, <a href="https://publications.waset.org/abstracts/search?q=DPPH%20free%20radical" title=" DPPH free radical"> DPPH free radical</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20vitro%20experiments" title=" in vitro experiments"> in vitro experiments</a>, <a href="https://publications.waset.org/abstracts/search?q=biochemical%20parameters" title=" biochemical parameters"> biochemical parameters</a> </p> <a href="https://publications.waset.org/abstracts/106698/study-of-toxic-effect-and-anti-oxidative-activity-of-a-v-amidophosphonates" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/106698.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">165</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">14</span> Paramecuim as a Model for the Evaluation of Toxicity (Growth, Total Proteins, Respiratory and GSH Bio Marker Changes) Observed after Treatment with Essential Oils Isolated from Artemisia herba-alba Plant of Algeria</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bouchiha%20Hanene">Bouchiha Hanene</a>, <a href="https://publications.waset.org/abstracts/search?q=Rouabhi%20Rachid"> Rouabhi Rachid</a>, <a href="https://publications.waset.org/abstracts/search?q=Bouchama%20Khaled"> Bouchama Khaled</a>, <a href="https://publications.waset.org/abstracts/search?q=Djebar%20Berrebbah%20Houraya"> Djebar Berrebbah Houraya</a>, <a href="https://publications.waset.org/abstracts/search?q=Djebar%20Mohamed%20Reda"> Djebar Mohamed Reda</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Recently, some natural products such as essentials oils (EOs) have been used in the fields as alternative to synthetic compounds, to minimize the negative impacts to the environment. This fact has led to questions about the possible impact of EOs on ecosystems. Currently in toxicology, the use of alternative models can help to understand the mechanisms of toxic action, at different levels of organization of ecosystems. Algae, protozoa and bacteria form the base of the food chain and protozoan cells are used as bioindicators often of pollution in environment. Unicellular organisms offer the possibility of direct study of independent cells with specific characteristics of individual cells and whole organisms at the same time. This unicellular facilitates the study of physiological processes, and effects of pollutants at the cellular level, which makes it widely used to assess the toxic effects of various xenobiotics. This study aimed to verify the effects of EOs of one famous plant used tremendously in our folk medicine, namely Artemisia herba alba in causing acute toxicity (24 hours) and chronic (15 days) toxicity for model cellular (Paramecium sp). To this end, cellular’s of paramecium were exposed to various concentrations (Three doses were chosen) of EOs extracted from plant (Artemisia herba alba). In the first experiment, the cellular s cultures were exposed for 48 hours to different concentrations to determine the median lethal concentration (DL50). We followed the evolution of physiological parameters (growth), biochemical (total proteins, respiratory metabolism), as well as the variations of a bio marker the GSH. Our results highlighted a light inhibition of the growth of the protozoa as well as a disturbance of the contents of total proteins and a reduction in the reduced rate of glutathione. The polarographic study revealed a stimulation of the consumption of O2 and this at the treated cells. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=essential%20oils" title="essential oils">essential oils</a>, <a href="https://publications.waset.org/abstracts/search?q=protozoa" title=" protozoa"> protozoa</a>, <a href="https://publications.waset.org/abstracts/search?q=bio%20indicators" title=" bio indicators"> bio indicators</a>, <a href="https://publications.waset.org/abstracts/search?q=toxicity" title=" toxicity"> toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=Growth" title=" Growth"> Growth</a>, <a href="https://publications.waset.org/abstracts/search?q=bio%20marker" title=" bio marker"> bio marker</a>, <a href="https://publications.waset.org/abstracts/search?q=proteins" title=" proteins"> proteins</a>, <a href="https://publications.waset.org/abstracts/search?q=polarographic" title=" polarographic"> polarographic</a> </p> <a href="https://publications.waset.org/abstracts/40445/paramecuim-as-a-model-for-the-evaluation-of-toxicity-growth-total-proteins-respiratory-and-gsh-bio-marker-changes-observed-after-treatment-with-essential-oils-isolated-from-artemisia-herba-alba-plant-of-algeria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/40445.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">346</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">13</span> Phytoremediation of Heavy Metals by Phragmites Australis at Oeud Meboudja Annaba Algeria</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kleche%20Myriam">Kleche Myriam</a>, <a href="https://publications.waset.org/abstracts/search?q=Ziane%20Nadia"> Ziane Nadia</a>, <a href="https://publications.waset.org/abstracts/search?q=Berrebbah%20Houria"> Berrebbah Houria</a>, <a href="https://publications.waset.org/abstracts/search?q=Djebar%20Mohammed%20Reda"> Djebar Mohammed Reda</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The Phytoremediation has now become a necessity. Thus, in our work, we are interested in the biological wastewater treatment of Oued Meboudja. The physicochemical analysis of water after treatment showed a significant reduction of suspended matter, COD and BOD5 and rate of metals in roots for example iron and zinc. We also highlighted some significant changes in biometric and physiological parameters such as increasing the number of roots and increased respiratory metabolism through the oxygen consumption in isolated roots of Phragmites australis, placed in a polluted environment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=phragmites%20australis" title="phragmites australis">phragmites australis</a>, <a href="https://publications.waset.org/abstracts/search?q=roots" title=" roots"> roots</a>, <a href="https://publications.waset.org/abstracts/search?q=phytoremediation" title=" phytoremediation"> phytoremediation</a>, <a href="https://publications.waset.org/abstracts/search?q=iron" title=" iron"> iron</a>, <a href="https://publications.waset.org/abstracts/search?q=zinc" title=" zinc"> zinc</a> </p> <a href="https://publications.waset.org/abstracts/17512/phytoremediation-of-heavy-metals-by-phragmites-australis-at-oeud-meboudja-annaba-algeria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/17512.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">497</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">12</span> Influence of Physico-Chemical Changes in the Environment on the Behavior of Tadpoles Rana Saharica: Case of Fungicide (Artea 330ec)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20Zouainia">S. Zouainia</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Djebar"> R. Djebar</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20Berrebah"> H. Berrebah</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Sayeb"> A. Sayeb</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This work focused on the study of physiological and biochemical changes observed in tadpoles exposed to fungicide Rana saharica Artea 330ec recently introduced in Algeria. For this, we tested the effect of xenobiotics on growth and development of tadpoles; among the studied parameters: total protein, glutathione and respiratory activity. The study of physiological parameters showed that the tadpoles change perfectly in the absence of toxic and in favorable conditions (pH, temperature). Our results showed an increased rate of protein and GSH in the presence of the fungicide Artea 330ec. The latter causes uninhibited very highly significant respiratory activity of tadpoles treated. The presence of xenobiotics in the breeding tadpoles water causes disturbances in behavior and food metabolism. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=amphibians" title="amphibians">amphibians</a>, <a href="https://publications.waset.org/abstracts/search?q=fungicides" title=" fungicides"> fungicides</a>, <a href="https://publications.waset.org/abstracts/search?q=pesticides" title=" pesticides"> pesticides</a>, <a href="https://publications.waset.org/abstracts/search?q=pollution" title=" pollution"> pollution</a> </p> <a href="https://publications.waset.org/abstracts/19163/influence-of-physico-chemical-changes-in-the-environment-on-the-behavior-of-tadpoles-rana-saharica-case-of-fungicide-artea-330ec" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/19163.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">408</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> Evaluation of Toxicity of Some Fungicides Against the Pathogen Fusarium sp.</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20Djekoun">M. Djekoun</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20Berrebah"> H. Berrebah</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20R.%20Djebar"> M. R. Djebar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Fusarium wilt attacks the plants of major economic interest including wheat. This disease causes many problems for farmers and economic loss resulting are often very heavy. Chemical control is currently one of the most effective ways to fight against these diseases. In this study, the efficacy of three fungicides (tebuconazole, thiram and fludioxonil - difenoconazole mixture) was tested, in vitro, on the phytopathogenic Fusarium sp. isolated from seeds of wheat. The active ingredients were tested at different concentrations: 0.06, 1.39, 2.79, 5.58, and 11.16 mg/l for tebuconazole, 0.035, 0.052, 0.105, 0.21, and 0.42 mg/l for thiram and finally, for the mixture fludioxonil- difenoconazole 4 concentrations were tested : 0.05, 0.1, 0.5, and 1 mg/l. Toxicity responses were expressed as the effective concentration, which inhibits mycelial growth by 50%, (EC50). Of the three selected fungicides, thirame proved to be the most effective with EC50 value of the order of 0,15 mg/l followed by the mixture of fludioxonil- difenoconazole with 0,27 mg/l and finally tebuconazole with a value of 3.79 mg/l. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fusarium%20sp" title="Fusarium sp">Fusarium sp</a>, <a href="https://publications.waset.org/abstracts/search?q=thiram" title=" thiram"> thiram</a>, <a href="https://publications.waset.org/abstracts/search?q=tebuconazole" title=" tebuconazole"> tebuconazole</a>, <a href="https://publications.waset.org/abstracts/search?q=fludioxonil" title=" fludioxonil"> fludioxonil</a>, <a href="https://publications.waset.org/abstracts/search?q=difenoconazole" title=" difenoconazole"> difenoconazole</a>, <a href="https://publications.waset.org/abstracts/search?q=EC50" title=" EC50"> EC50</a> </p> <a href="https://publications.waset.org/abstracts/21160/evaluation-of-toxicity-of-some-fungicides-against-the-pathogen-fusarium-sp" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21160.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">544</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> Toxicity of the Chlorfenapyr: Growth Inhibition and Induction of Oxidative Stress on a Freshwater Protozoan, Paramecium Sp.</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Houne%C3%AFda%20Benbouzid">Houneïda Benbouzid</a>, <a href="https://publications.waset.org/abstracts/search?q=Houria%20Berrebbah"> Houria Berrebbah</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammed-R%C3%A9da%20Djebar"> Mohammed-Réda Djebar </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The toxicological impacts of the increasing number of synthetic compounds present in the aquatic environment are assessed predominantly in laboratory studies where test organisms are exposed to a range of concentrations of single compounds. The bio-indicator Paramecium sp., characterized by a short life cycle, rapid multiplication and normal behavior that may be affected by the presence of pollutants. We therefore investigated the inhibitory effect of a newly synthesized acaricide: the chlorfenapyr tested at concentrations of 250, 300, and 350 µM on a pure culture of Paramecium sp. during 6 day. Paramecia treated with different concentrations of Chlorfenapyr illustrate strong inhibition of cell growth from the second day of treatment. Low levels of glutathione, increased glutathione S-transferase and the decrease in respiratory metabolism, recorded in the presence of different concentrations of Chlorfenapyr, involve the activation of detoxification system. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Paramecium%20sp." title="Paramecium sp.">Paramecium sp.</a>, <a href="https://publications.waset.org/abstracts/search?q=chlorfenapyr" title=" chlorfenapyr"> chlorfenapyr</a>, <a href="https://publications.waset.org/abstracts/search?q=oxidative%20enzymes" title=" oxidative enzymes"> oxidative enzymes</a>, <a href="https://publications.waset.org/abstracts/search?q=detoxification" title=" detoxification"> detoxification</a> </p> <a href="https://publications.waset.org/abstracts/13236/toxicity-of-the-chlorfenapyr-growth-inhibition-and-induction-of-oxidative-stress-on-a-freshwater-protozoan-paramecium-sp" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13236.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">367</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> Effects of Some Fungicides on Mycelial Growth of Fusarium spp.</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20Djekoun">M. Djekoun</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20Berrebah"> H. Berrebah</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20R.%20Djebar"> M. R. Djebar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Fusarium wilt is destructive disease of cereal crops with small grains. It affects yields but also the quality of the crop and economic losses arising are often very heavy. Chemical control is currently one of the most effective ways to fight against these diseases. In this study, the efficacy of three fungicides (tebuconazole, thiram, and fludioxonil-difenoconazole mixture) was tested. In vitro, on the phytopathogenic Fusarium spp. isolated from seeds of wheat. The active ingredients were tested at different concentrations: 0.06, 1.39, 2.79, 5.58, and 11.16 mg/l for tebuconazole, 0.035, 0.052, 0.105, 0.21, and 0.42 mg/l for thiram and finally, for the mixture fludioxonil-difenoconazole 4 concentrations were tested: 0.05, 0.1, 0.5 and 1 mg/l. Toxicity responses were expressed as effective concentration, which inhibits mycelial growth by 50%, (EC50). Of the three selected fungicides, thirame proved to be the most effective with EC50 value of the order of 0,15 mg/l followed by the mixture of fludioxonil-difenoconazole with 0,27mg/l and finally tebuconazole with a value of 3.79 mg/l. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fusarium%20spp." title="Fusarium spp.">Fusarium spp.</a>, <a href="https://publications.waset.org/abstracts/search?q=thiram" title=" thiram"> thiram</a>, <a href="https://publications.waset.org/abstracts/search?q=tebuconazole" title=" tebuconazole"> tebuconazole</a>, <a href="https://publications.waset.org/abstracts/search?q=fludioxonil" title=" fludioxonil"> fludioxonil</a>, <a href="https://publications.waset.org/abstracts/search?q=difenoconazole" title=" difenoconazole"> difenoconazole</a>, <a href="https://publications.waset.org/abstracts/search?q=percentage%20of%20inhibition" title=" percentage of inhibition"> percentage of inhibition</a>, <a href="https://publications.waset.org/abstracts/search?q=EC50" title=" EC50"> EC50</a> </p> <a href="https://publications.waset.org/abstracts/18858/effects-of-some-fungicides-on-mycelial-growth-of-fusarium-spp" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18858.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">366</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Effect of Dust Rejected by Iron and Steel Complex on Roots of Bean Phaseolus vulgaris</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Labiba%20Zerari%20Bourafa">Labiba Zerari Bourafa</a>, <a href="https://publications.waset.org/abstracts/search?q=Djebar%20Mohamed%20Reda"> Djebar Mohamed Reda</a>, <a href="https://publications.waset.org/abstracts/search?q=Berrebah%20Houria"> Berrebah Houria</a>, <a href="https://publications.waset.org/abstracts/search?q=Khadri%20Sihem"> Khadri Sihem</a>, <a href="https://publications.waset.org/abstracts/search?q=Chiheb%20Linda"> Chiheb Linda</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The study of the effect of metal dust (pollutants) was performed on higher plant white beans Phaseolus vulgaris; the experience took place in cellular toxicology laboratory (in vitro culture). The seeds of the bean Phaseolus vulgaris are cultured in a metal contaminated dust medium (a single treatment by different increasing doses), at a rate of 10 seeds per box, for 10 days. The measurement of morpho-metric parameters is performed during the first 96 hours that follow the germination; while the dosage of the proline, the protein content and histological sections are formed on the tenth day (240 h). All morpho-metric and biochemical parameters measured were highly disturbed by metal dust; histological sections confirm this disurbance. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=conductive%20fabrics" title="conductive fabrics">conductive fabrics</a>, <a href="https://publications.waset.org/abstracts/search?q=metal%20dust" title=" metal dust"> metal dust</a>, <a href="https://publications.waset.org/abstracts/search?q=osmoticums" title=" osmoticums"> osmoticums</a>, <a href="https://publications.waset.org/abstracts/search?q=roots" title=" roots"> roots</a>, <a href="https://publications.waset.org/abstracts/search?q=Phaseolus%20vulgaris" title=" Phaseolus vulgaris"> Phaseolus vulgaris</a> </p> <a href="https://publications.waset.org/abstracts/17722/effect-of-dust-rejected-by-iron-and-steel-complex-on-roots-of-bean-phaseolus-vulgaris" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/17722.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">376</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Encounters with the Other Sisters of the Past: the Role of Colonial History and Memory in the Adjustment of the Postcolonial Female Identity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fatiha%20Ka%C3%AFd%20Berrahal">Fatiha Kaïd Berrahal</a>, <a href="https://publications.waset.org/abstracts/search?q=Nassima%20Ka%C3%AFd"> Nassima Kaïd</a>, <a href="https://publications.waset.org/abstracts/search?q=Djihad%20Affaf%20Selt"> Djihad Affaf Selt</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present paper is a comparative analysis of the Algerian writer Assia Djebar’s women of Algiers in Their Apartment (1982) and the Anglo-Egyptian Ahdaf Soueif’s The Map of Love (1999) foregrounded on the female protagonists’ painfully common colonial and patriarchal experiences, though in different geographical regions of North Africa. This study raises questions pertaining, first, to the emerging contemporary genre “Historiographic meta-fiction” in which the novels examined could be inscribed, then, the interplay of colonial history and personal memory that impinges on the development of the identity of the post-colonial female subject. As the novels alternate between the historical and the autobiographical, we currently seek to understand how it is pertinent and pressing for women to excavate the lost and occluded stories of the past for the adjustment of their present personal identities, which are undoubtedly an important part of the identity of a nation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=postcolonial%20feminism" title="postcolonial feminism">postcolonial feminism</a>, <a href="https://publications.waset.org/abstracts/search?q=islamic%20feminism" title=" islamic feminism"> islamic feminism</a>, <a href="https://publications.waset.org/abstracts/search?q=memory" title=" memory"> memory</a>, <a href="https://publications.waset.org/abstracts/search?q=histoirographic%20metafiction" title=" histoirographic metafiction"> histoirographic metafiction</a> </p> <a href="https://publications.waset.org/abstracts/19905/encounters-with-the-other-sisters-of-the-past-the-role-of-colonial-history-and-memory-in-the-adjustment-of-the-postcolonial-female-identity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/19905.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">643</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Study of the Antimicrobial Activity of the Extract of the Eucalyptus camaldulensis stemming from the Algerian Northeast</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Meksem%20Nabila">Meksem Nabila</a>, <a href="https://publications.waset.org/abstracts/search?q=Bordjiba%20Ouahiba"> Bordjiba Ouahiba</a>, <a href="https://publications.waset.org/abstracts/search?q=Meraghni%20Messaouda"> Meraghni Messaouda</a>, <a href="https://publications.waset.org/abstracts/search?q=Meksem%20Amara%20Leila"> Meksem Amara Leila</a>, <a href="https://publications.waset.org/abstracts/search?q=Djebar%20Mohhamed%20Reda"> Djebar Mohhamed Reda</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The problems of protection of the cultures are being more and more important that they interest great number of farmers and scientists because of the excessive use of the organic phytosanitary products of synthesis that causes fatal damages on the environment. To reduce the inconveniences produced by these pesticides, the use of "biopesticides" originated from plants could be an alternative. The aim of this work is the valuation of a botanical species: Eucalyptus camaldulensis from Northeastern Algeria which extracts are supposed to have an antimicrobial activity, similar to pesticides. The extraction of secondary metabolites from the leaves of E. camaldulensis was realized using methanol and water, and measurements of total polyphenols were made by spectrometric method. Determination of the antimicrobial activity of the extracts at issue was realized in vitro on phyto-pathogenic fungal and bacterial stumps. Tests of comparison were included in the essays by using the chemical pesticidal products of synthesis. The obtained results show that the plant contains polyphenols with an efficiency mattering of the order of 22 %. These polyphenols have a strong fungicidal and bactericidal pesticidal activity against various microbial stumps and the values of the zones of inhibition are more important compared with that obtained in the presence of the chemicals of synthesis (fungicide). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=eucalyptus%20camaldulensis" title="eucalyptus camaldulensis">eucalyptus camaldulensis</a>, <a href="https://publications.waset.org/abstracts/search?q=biopesticide" title=" biopesticide"> biopesticide</a>, <a href="https://publications.waset.org/abstracts/search?q=polyphenols" title=" polyphenols"> polyphenols</a>, <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20activity" title=" antimicrobial activity"> antimicrobial activity</a> </p> <a href="https://publications.waset.org/abstracts/29478/study-of-the-antimicrobial-activity-of-the-extract-of-the-eucalyptus-camaldulensis-stemming-from-the-algerian-northeast" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/29478.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">432</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Comparison of Serological and Molecular Diagnosis of Cerebral Toxoplasmosis in Blood and Cerebrospinal Fluid in HIV Infected Patients</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Berredjem%20Hajira">Berredjem Hajira</a>, <a href="https://publications.waset.org/abstracts/search?q=Benlaifa%20Meriem"> Benlaifa Meriem</a>, <a href="https://publications.waset.org/abstracts/search?q=Becheker%20Imene"> Becheker Imene</a>, <a href="https://publications.waset.org/abstracts/search?q=Bardi%20Rafika"> Bardi Rafika</a>, <a href="https://publications.waset.org/abstracts/search?q=Djebar%20Med%20Reda"> Djebar Med Reda</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Recent acquired or reactivation T.gondii infection is a serious complication in HIV patients. Classical serological diagnosis relies on the detection of anti-Toxoplasma immunoglobulin ; however, serology may be unreliable in HIV immunodeficient patients who fail to produce significant titers of specific antibodies. PCR assays allow a rapid diagnosis of Toxoplasma infection. In this study, we compared the value of the PCR for diagnosing active toxoplasmosis in cerebrospinal fluid and blood samples from HIV patients. Anti-Toxoplasma antibodies IgG and IgM titers were determined by ELISA. In parallel, nested PCR targeting B1 gene and conventional PCR-ELISA targeting P30 gene were used to detect T. gondii DNA in 25 blood samples and 12 cerebrospinal fluid samples from patients in whom toxoplasmic encephalitis was confirmed by clinical investigations. A total of 15 negative controls were used. Serology did not contribute to confirm toxoplasmic infection, as IgG and IgM titers decreased early. Only 8 out 25 blood samples and 5 out 12 cerebrospinal fluid samples PCRs yielded a positive result. 5 patients with confirmed toxoplasmosis had positive PCR results in either blood or cerebrospinal fluid samples. However, conventional nested B1 PCR gave best results than the P30 gene one for the detection of T.gondii DNA in both samples. All samples from control patients were negative. This study demonstrates the unusefulness of the serological tests and the high sensitivity and specificity of PCR in the diagnosis of toxoplasmic encephalitis in HIV patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cerebrospinal%20fluid" title="cerebrospinal fluid">cerebrospinal fluid</a>, <a href="https://publications.waset.org/abstracts/search?q=HIV" title=" HIV"> HIV</a>, <a href="https://publications.waset.org/abstracts/search?q=Toxoplasmosis" title=" Toxoplasmosis"> Toxoplasmosis</a>, <a href="https://publications.waset.org/abstracts/search?q=PCR" title=" PCR"> PCR</a> </p> <a href="https://publications.waset.org/abstracts/25273/comparison-of-serological-and-molecular-diagnosis-of-cerebral-toxoplasmosis-in-blood-and-cerebrospinal-fluid-in-hiv-infected-patients" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/25273.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">376</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Deltamethrin-Induces Oxidative Stress to the Freshwater Ciliate Model: Paramecium tetraurelia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amamra%20Ryma">Amamra Ryma</a>, <a href="https://publications.waset.org/abstracts/search?q=Djebar%20Mohamed%20Reda"> Djebar Mohamed Reda</a>, <a href="https://publications.waset.org/abstracts/search?q=Moumeni%20Ouissem"> Moumeni Ouissem</a>, <a href="https://publications.waset.org/abstracts/search?q=Otmani%20Hadjer"> Otmani Hadjer</a>, <a href="https://publications.waset.org/abstracts/search?q=Berrebbah%20Houria"> Berrebbah Houria</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The problem of environmental contamination by the excessive use of organics cannot be neglected. Extensive application is usually companied with serious problems and health risk. It is established that many chemicals, in common use, can produce some toxic effects on biological systems through their mode of action or by production of free radicals that damage all cell compounds. Deltamethrin, a widely used type II pyrethroid pesticide, is one of the most common contaminants in freshwater aquatic system. In this study, we investigate the effects of deltamethrin exposure on the induction of oxidative stress to the freshwater ciliate Paramecium tetraurelia. After the treatment of paramecium cells with increasing concentrations of insecticide, we followed up the growth kinetics, generation time and the percentage response. Also, we studied the variation in biomarkers of stress such as: GSH content, GST, GPX and CAT activities. Our results showed a significant decrease in the proliferation of cells correlated by the decrease in generation number and the increase in generation time. Also, we noted an inhibition in the percentage response. The monitoring of biomarkers revealed depletion in GSH content in a proportional and dose dependent manner accompanied by an increase in the GST activity. In parallel, a strong induction in the CAT and GPX activities was noted specially for the highest dose. In summary, under the current experimental conditions, deltamethrin is highly toxic to the freshwater ciliate Paramecium tetraurelia. Exposure to low concentrations showed significant adverse on growth accompanied with the induction of oxidative damage supported by the decrease in GSH content and the intensification of the antioxidant enzymes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=deltamethrin" title="deltamethrin">deltamethrin</a>, <a href="https://publications.waset.org/abstracts/search?q=Paramecium%20tetraurelia" title=" Paramecium tetraurelia"> Paramecium tetraurelia</a>, <a href="https://publications.waset.org/abstracts/search?q=growth" title=" growth"> growth</a>, <a href="https://publications.waset.org/abstracts/search?q=oxidative%20stress" title=" oxidative stress"> oxidative stress</a>, <a href="https://publications.waset.org/abstracts/search?q=biomarkers" title=" biomarkers"> biomarkers</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant" title=" antioxidant"> antioxidant</a> </p> <a href="https://publications.waset.org/abstracts/17533/deltamethrin-induces-oxidative-stress-to-the-freshwater-ciliate-model-paramecium-tetraurelia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/17533.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">467</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> The Effect of a Weed-Killer Sulfonylurea on Durum Wheat (Triticum Durum Desf)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=L.%20Meksem%20Amara">L. Meksem Amara</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Ferfar"> M. Ferfar</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20Meksem"> N. Meksem</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20R.%20Djebar"> M. R. Djebar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The wheat is the cereal the most consumed in the world. In Algeria, the production of this cereal covers only 20 in 25 % of the needs for the country, the rest being imported. To improve the efficiency and the productivity of the durum wheat, the farmers turn to the use of pesticides: weed-killers, fungicides and insecticides. However this use often entrains losses of products more at least important contaminating the environment and all the food chain. Weed-killers are substances developed to control or destroy plants considered unwanted. That they are natural or produced by the human being (molecule of synthesis), the absorption and the metabolization of weed-killers by plants cause the death of these plants. In this work, we set as goal the evaluation of the effect of a weed-killer sulfonylurea, the CossackOD with various concentrations (0, 2, 4 and 9 µg) on variety of Triticum durum: Cirta. We evaluated the plant growth by measuring the leaves and root length, compared with the witness as well as the content of proline and analyze the level of one of the antioxydative enzymes: catalase, after 14 days of treatment. Sulfonylurea is foliar and root weed-killers inhibiting the acetolactate synthase: a vegetable enzyme essential to the development of the plant. This inhibition causes the ruling of the growth then the death. The obtained results show a diminution of the average length of leaves and roots this can be explained by the fact that the ALS inhibitors are more active in the young and increasing regions of the plant, what inhibits the cellular division and talks a limitation of the foliar and root’s growth. We also recorded a highly significant increase in the proline levels and a stimulation of the catalase activity. As a response to increasing the herbicide concentrations a particular increases in antioxidative mechanisms in wheat cultivar Cirta suggest that the high sensitivity of Cirta to this sulfonylurea herbicide is related to the enhanced production and oxidative damage of reactive oxygen species. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=sulfonylurea" title="sulfonylurea">sulfonylurea</a>, <a href="https://publications.waset.org/abstracts/search?q=triticum%20durum" title=" triticum durum"> triticum durum</a>, <a href="https://publications.waset.org/abstracts/search?q=oxydative%20stress" title=" oxydative stress"> oxydative stress</a>, <a href="https://publications.waset.org/abstracts/search?q=toxicity" title=" toxicity"> toxicity</a> </p> <a href="https://publications.waset.org/abstracts/29490/the-effect-of-a-weed-killer-sulfonylurea-on-durum-wheat-triticum-durum-desf" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/29490.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">413</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> The Evaluation of the Effect of a Weed-Killer Sulfonylurea on Durum Wheat (Triticum durum Desf)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Meksem%20Amara%20Leila">Meksem Amara Leila</a>, <a href="https://publications.waset.org/abstracts/search?q=Ferfar%20Meriem"> Ferfar Meriem</a>, <a href="https://publications.waset.org/abstracts/search?q=Meksem%20Nabila"> Meksem Nabila</a>, <a href="https://publications.waset.org/abstracts/search?q=Djebar%20Mohammed%20Reda"> Djebar Mohammed Reda</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The wheat is the cereal the most consumed in the world. In Algeria, the production of this cereal covers only 20 in 25 % of the needs for the country, the rest being imported. To improve the efficiency and the productivity of the durum wheat, the farmers turn to the use of pesticides: weed-killers, fungicides and insecticides. However this use often entrains losses of products more at least important contaminating the environment and all the food chain. Weed-killers are substances developed to control or destroy plants considered unwanted. That they are natural or produced by the human being (molecule of synthesis), the absorption and the metabolization of weed-killers by plants cause the death of these plants.In this work, we set as goal the evaluation of the effect of a weed-killer sulfonylurea, the CossackOD with various concentrations (0, 2, 4 and 9 µg) on variety of Triticum durum: Cirta. We evaluated the plant growth by measuring the leaves and root length, compared with the witness as well as the content of proline and analyze the level of one of the antioxydative enzymes: catalse, after 14 days of treatment. Sulfonylurea is foliar and root weed-killers inhibiting the acetolactate synthase: a vegetable enzyme essential to the development of the plant. This inhibition causes the ruling of the growth then the death. The obtained results show a diminution of the average length of leaves and roots this can be explained by the fact that the ALS inhibitors are more active in the young and increasing regions of the plant, what inhibits the cellular division and talks a limitation of the foliar and root’s growth. We also recorded a highly significant increase in the proline levels and a stimulation of the catalase activity. As a response to increasing the herbicide concentrations a particular increases in antioxidative mechanisms in wheat cultivar Cirta suggest that the high sensitivity of Cirta to this sulfonylurea herbicide is related to the enhanced production and oxidative damage of reactive oxygen species. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=sulfonylurea" title="sulfonylurea">sulfonylurea</a>, <a href="https://publications.waset.org/abstracts/search?q=Triticum%20durum" title=" Triticum durum"> Triticum durum</a>, <a href="https://publications.waset.org/abstracts/search?q=oxydative%20stress" title=" oxydative stress"> oxydative stress</a>, <a href="https://publications.waset.org/abstracts/search?q=Toxicity" title=" Toxicity"> Toxicity</a> </p> <a href="https://publications.waset.org/abstracts/29487/the-evaluation-of-the-effect-of-a-weed-killer-sulfonylurea-on-durum-wheat-triticum-durum-desf" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/29487.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">424</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> In vitro and in vivo Potential Effect of the N-Acylsulfonamide Bis-oxazolidin-2-ones on Toxoplasma gondii</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Benlaifa%20Meriem">Benlaifa Meriem</a>, <a href="https://publications.waset.org/abstracts/search?q=Berredjem%20Hajira"> Berredjem Hajira</a>, <a href="https://publications.waset.org/abstracts/search?q=Bouasla%20Radia"> Bouasla Radia</a>, <a href="https://publications.waset.org/abstracts/search?q=Berredjem%20Malika"> Berredjem Malika</a>, <a href="https://publications.waset.org/abstracts/search?q=Djebar%20Med%20Reda"> Djebar Med Reda</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Toxoplasmosis is a cosmopolitan infection due to Toxoplasma gondii (T.gondii). It is a significant cause of congenital disease and an important opportunistic pathogen which has become a worldwide increasing problem due to the AIDS epidemic. Current available drugs do not give satisfactory results and often have only a static and several adverse side effects as it is the case of pyrimethamine. So, the need to develop and evaluate new drugs is critical. The purpose of this study is to investigate the in vitro and in vivo effects of the new chiral N-acylsulfonamide bis-oxazolidin-2-ones on T.gondii. In this study, anti-T.gondii RH strain activities, of two new chiral N-acylsulfonamide bis-oxazolidin-2-ones were evaluated in vitro, using a MRC-5 fibroblast tissue cultures to determine the concentration that inhibit parasite multiplication by 50% (IC50) of each drug and in vivo, by PCR detection of the tachyzoites in mice ascites after new molecules treatment, using the 35-fold repetitive B1 gene of T.gondii. The in vitro results demonstrated that the treatment with the tested molecules decreased the amount of tachyzoites in cell culture in a dose-dependent manner. The inhibition was complete for concentrations over 4 mg/ml. The IC50 of Mol 1 and Mol 2 were 1.5 and 3 mg/ml, respectively, and were quite similar to the control one (2 mg/ml). The Mol 1 was highly active against T.gondii in cell cultures than Mol 2; these results were similar to those of sulfadiazine-treated group (p < 0.05). Toxoplasma-specific DNA was demonstrated in all ascites samples from infected mice of the different tested groups. Mol 1 showed better effect than Mol 2, but it did not completely inhibit the parasite proliferation. The intensity of amplification products increased when the treatment started late after infection. These findings suggest continuous parasite replication despite the treatment. In conclusion, our results showed a promising treatment effect of the tested molecules and suggest that in vitro, the Mol 1, and Mol 2 have a dose-dependent effect and a high cytotoxicity on the studied cells. The present study revealed that concentration and duration of tested molecules treatment are major factors that influence the course of Toxoplasma infection in infected mice. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cytotoxicity" title="cytotoxicity">cytotoxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=PCR" title=" PCR"> PCR</a>, <a href="https://publications.waset.org/abstracts/search?q=sulfonamide" title=" sulfonamide"> sulfonamide</a>, <a href="https://publications.waset.org/abstracts/search?q=Toxoplasma%20gondii" title=" Toxoplasma gondii"> Toxoplasma gondii</a> </p> <a href="https://publications.waset.org/abstracts/24904/in-vitro-and-in-vivo-potential-effect-of-the-n-acylsulfonamide-bis-oxazolidin-2-ones-on-toxoplasma-gondii" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24904.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">504</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); 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