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href="https://unicap.academia.edu/LeonieSarubbo">Leonie Sarubbo</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Catholic University of Pernambuco</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://unisimonbolivar.academia.edu/GAroca"><img class="profile-avatar u-positionAbsolute" alt="GUSTAVO Aroca" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/38478201/17781773/17806889/s200_g..aroca.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://unisimonbolivar.academia.edu/GAroca">GUSTAVO Aroca</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Universidad Simón Bolívar (Barranquilla)</p></div></div><div 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href="https://dentalsedationgroup.academia.edu/StuartBrink"><img class="profile-avatar u-positionAbsolute" alt="Stuart J Brink" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/50659940/13371257/14602621/s200_stuart.brink.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://dentalsedationgroup.academia.edu/StuartBrink">Stuart J Brink</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Tufts University School of Medicine</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://brocku.academia.edu/DragosSimandan"><img class="profile-avatar u-positionAbsolute" alt="Dragos Simandan" border="0" onerror="if (this.src != 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class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Jim Collins</h3></div><div class="js-work-strip profile--work_container" data-work-id="71692473"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/71692473/Elimination_Rates_of_Dioxin_Congeners_in_Former_Chlorophenol_Workers_from_Midland_Michigan"><img alt="Research paper thumbnail of Elimination Rates of Dioxin Congeners in Former Chlorophenol Workers from Midland, Michigan" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link 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href="https://www.academia.edu/65849717/Cohort_study_of_workers_at_a_New_Zealand_agrochemical_plant_to_assess_the_effect_of_dioxin_exposure_on_mortality"><img alt="Research paper thumbnail of Cohort study of workers at a New Zealand agrochemical plant to assess the effect of dioxin exposure on mortality" class="work-thumbnail" src="https://attachments.academia-assets.com/77268294/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849717/Cohort_study_of_workers_at_a_New_Zealand_agrochemical_plant_to_assess_the_effect_of_dioxin_exposure_on_mortality">Cohort study of workers at a New Zealand agrochemical plant to assess the effect of dioxin exposure on mortality</a></div><div class="wp-workCard_item"><span>BMJ open</span><span>, Jan 17, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To describe how the exposure to 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD) influenced mortality in...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To describe how the exposure to 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD) influenced mortality in a cohort of workers who were exposed more recently, and at lower levels, than other cohorts of trichlorophenol process workers. A cohort study. An agrochemical plant in New Zealand PARTICIPANTS: 1,599 men and women working between 1 January 1969 and 1 November 1988 at a plant producing the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) with TCDD as a contaminant. Cumulative TCDD exposure was estimated for each individual in the study by a toxicokinetic model. Calculation of cause-specific standardised mortality ratios (SMRs) and 95% confidence intervals (95% CI&#39;s) compared those never and ever exposed to TCDD. Dose-response trends were assessed firstly through SMRs stratified in quartiles of cumulative TCCD exposure, and secondly with a proportional hazards model. The model intercept of 5.1 ppt of TCDD was consistent with background TCDD concentrations in New Zealand among ol...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a67d7ef840513773d110c7b21a8d4d0f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268294,"asset_id":65849717,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268294/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849717"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849717"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849717; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849716"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849716/A_systematic_review_of_epidemiologic_studies_of_styrene_and_cancer"><img alt="Research paper thumbnail of A systematic review of epidemiologic studies of styrene and cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/77268305/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849716/A_systematic_review_of_epidemiologic_studies_of_styrene_and_cancer">A systematic review of epidemiologic studies of styrene and cancer</a></div><div class="wp-workCard_item"><span>Critical reviews in toxicology</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Previous epidemiology reviews of exposure to styrene and the risk of cancer considered studies pu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Previous epidemiology reviews of exposure to styrene and the risk of cancer considered studies published through 13 November 2013. Since then, additional relevant research has been published. No review has included meta-analyses. The current systematic review considered research published through June 2017; included meta-analyses of the relationship between any exposure to styrene and cancers identified as being of concern, including non-Hodgkin lymphoma (NHL), leukemia and cancers of the esophagus, pancreas, lung and kidney; and evaluated several other forms of cancer. Meta-relative risks for all studies were 1.14 (95% confidence interval (CI), 0.91-1.43) for NHL, 1.00 (95% CI, 0.80-1.26) for multiple myeloma, 0.98 (95% CI, 0.87-1.09) for all leukemia, 1.03 (95% CI, 0.92-1.15) for esophageal cancer, 1.02 (95% CI, 0.93-1.12) for pancreatic cancer, 1.09 (95% CI, 0.95-1.24) for lung cancer and 1.10 (95% CI, 0.99-1.22) for kidney cancer. Individual studies provided little evidence of e...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e9d9da5ce51987ca71c69be51cea8714" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268305,"asset_id":65849716,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268305/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849716"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849716"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849716; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849715"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849715/Incidence_of_Occupational_Asthma_and_Exposure_to_Toluene_Diisocyanate_in_the_United_States_Toluene_Diisocyanate_Production_Industry"><img alt="Research paper thumbnail of Incidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry" class="work-thumbnail" src="https://attachments.academia-assets.com/77268307/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849715/Incidence_of_Occupational_Asthma_and_Exposure_to_Toluene_Diisocyanate_in_the_United_States_Toluene_Diisocyanate_Production_Industry">Incidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry</a></div><div class="wp-workCard_item"><span>Journal of occupational and environmental medicine</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This study examines asthma risk in facilities producing toluene diisocyanate (TDI). A total of 19...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This study examines asthma risk in facilities producing toluene diisocyanate (TDI). A total of 197 workers were monitored from 2007 to 2012. TDI air concentrations were used to estimate exposures. The incidence of cases consistent with TDI-induced asthma was 0.009 per person-years (seven cases) or consistent with TDI-induced asthma or asthma indeterminate regarding work-relatedness was 0.012 (nine cases). Increased risk of cases consistent with TDI asthma was observed for cumulative (odds ratio [OR] = 2.08, 95% confidence interval [CI] 1.07 to 4.05) per logarithm parts per billion-years and peak TDI exposures (OR = 1.18, 95% CI 1.06 to 1.32) (logarithm parts per billion). There was a weak association with cumulative and peak exposures for decline of short-term forced expiratory volume in one second (FEV1). Asthma symptoms were associated with workers noticing an odor of TDI (OR 6.02; 95% CI 1.36 to 26.68). There is evidence that cumulative and peak exposures are associated with TDI-...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7394700b2598f974a4bcf97d06af05ce" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268307,"asset_id":65849715,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268307/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849715"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849715"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849715; 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</script> <div class="js-work-strip profile--work_container" data-work-id="65849713"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849713/Cancer_risk_for_chemical_workers_exposed_to_2_3_7_8_tetrachlorodibenzo_p_dioxin"><img alt="Research paper thumbnail of Cancer risk for chemical workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin" class="work-thumbnail" src="https://attachments.academia-assets.com/77268306/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849713/Cancer_risk_for_chemical_workers_exposed_to_2_3_7_8_tetrachlorodibenzo_p_dioxin">Cancer risk for chemical workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin</a></div><div class="wp-workCard_item"><span>Occupational and environmental medicine</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To describe the long term mortality experience of a cohort of 2187 male chemical production worke...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To describe the long term mortality experience of a cohort of 2187 male chemical production workers previously exposed to substantial levels of dioxin. Vital status for a previously identified cohort was determined for an additional 10 years, to 1995. Dioxin exposures took place before 1983 and were sufficient to result in chloracne in 245 individuals. Mortality rates were compared with national figures and with a large pool of co-workers in unrelated production jobs. All cancers combined (standardised mortality ratio (SMR) = 1.0, 95% CI 0.8 to 1.1) and lung cancer (SMR = 0.8, 95% CI 0.6 to 1.1) were at or below expected levels. Rates for soft tissue sarcoma (SMR = 2.4, 95% CI 0.3 to 8.6) and non-Hodgkin&#39;s lymphoma (SMR = 1.4, 95% CI 0.6 to 2.7) were greater than expected overall, but below expectation in the update period. No trend of increasing risk with increasing exposure was observed for these cancers. Workers who developed chloracne had very low all-cancer rates (SMR = 0.5...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="046c374e57d22606a1039a268e4c8539" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268306,"asset_id":65849713,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268306/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849713"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849713"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849713; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "046c374e57d22606a1039a268e4c8539" } } $('.js-work-strip[data-work-id=65849713]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849713,"title":"Cancer risk for chemical workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin","internal_url":"https://www.academia.edu/65849713/Cancer_risk_for_chemical_workers_exposed_to_2_3_7_8_tetrachlorodibenzo_p_dioxin","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[{"id":77268306,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77268306/thumbnails/1.jpg","file_name":"fda1abab26cd015a4cfc866d8b8b9006e91e.pdf","download_url":"https://www.academia.edu/attachments/77268306/download_file","bulk_download_file_name":"Cancer_risk_for_chemical_workers_exposed.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77268306/fda1abab26cd015a4cfc866d8b8b9006e91e-libre.pdf?1640352887=\u0026response-content-disposition=attachment%3B+filename%3DCancer_risk_for_chemical_workers_exposed.pdf\u0026Expires=1739852562\u0026Signature=HgFpVatzIwgB9e9H~zEpzrzwIM-8mRmtt0m8QXRli0aONQxcBrfumsEahX~h-XvqcJijoj2DCjKZmqhSmbd3I1uebe1-yYjfqd5izneklNazLyVsDSyCWuk2WwUDujMBiQTTWXDfUkM5s3CU32YizMrPKKx-zwtlOQzEyjfspF9ATFwjwuhBwnudNfTauoCy5I6NNcJicBBDR-yLci2JHgTbTSg~0MvYQ8iEHMvWsLLvhQE~LVB3mGHXEDlkNn9JyTSITrvaGhAmoojh5U~BbK7dvUfnQrO4RQs-cAZHJvgndDwcNIXmPyj38sdhTXL96GpHSh4vdekoClKnuENJRw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849712"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/65849712/Re_Respiratory_and_irritant_health_effects_of_ambient_volatile_organic_compounds_the_Kanawha_County_Health_Study"><img alt="Research paper thumbnail of Re: Respiratory and irritant health effects of ambient volatile organic compounds: the Kanawha County Health Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/65849712/Re_Respiratory_and_irritant_health_effects_of_ambient_volatile_organic_compounds_the_Kanawha_County_Health_Study">Re: Respiratory and irritant health effects of ambient volatile organic compounds: the Kanawha County Health Study</a></div><div class="wp-workCard_item"><span>American journal of epidemiology</span><span>, Jan 15, 1995</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849712"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849712"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849712; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849712]").text(description); $(".js-view-count[data-work-id=65849712]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849712; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849712']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65849712]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849712,"title":"Re: Respiratory and irritant health effects of ambient volatile organic compounds: the Kanawha County Health Study","internal_url":"https://www.academia.edu/65849712/Re_Respiratory_and_irritant_health_effects_of_ambient_volatile_organic_compounds_the_Kanawha_County_Health_Study","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849711"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849711/Brain_and_Central_Nervous_System_Cancer_and_Benign_Brain_Tumors_Among_Chemical_Plant_Workers_in_Texas"><img alt="Research paper thumbnail of Brain and Central Nervous System Cancer and Benign Brain Tumors Among Chemical Plant Workers in Texas" class="work-thumbnail" src="https://attachments.academia-assets.com/77268293/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849711/Brain_and_Central_Nervous_System_Cancer_and_Benign_Brain_Tumors_Among_Chemical_Plant_Workers_in_Texas">Brain and Central Nervous System Cancer and Benign Brain Tumors Among Chemical Plant Workers in Texas</a></div><div class="wp-workCard_item"><span>The Open Epidemiology Journal</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the early 1980's, a clustering of brain and central nervous system cancers was observed among ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the early 1980's, a clustering of brain and central nervous system cancers was observed among workers at a Texas City, Texas chemical plant. A series of studies with follow-up from 1941 to 1983 failed to identify an occupational cause. We added women and newly hired workers to these studies and expanded the follow-up from 1940 to 2001 using a retrospective cohort mortality design. The SMR for brain and central nervous system cancers was slightly less than expected (SMR=0.93, 95% CI 0.60-1.38) whereas the SMR for benign brain tumors was slightly greater than expected (SMR=1.50, 95% CI 0.72-2.76) during the entire observation period. SMRs were close to expected levels when examining sex, wage type, year of hire, years of latency, and duration of employment for these causes. We observed high rates of brain and central nervous system cancers from 1970 to 1984 but lower rates in the other periods. We conclude that the excess cancer and tumor mortality reported in the earlier studies may be a random cluster and unrelated to workplace exposures.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eb9341c91b1057c83e9ca26bace7248e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268293,"asset_id":65849711,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268293/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849711"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849711"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849711; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849711]").text(description); $(".js-view-count[data-work-id=65849711]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849711; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849711']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "eb9341c91b1057c83e9ca26bace7248e" } } $('.js-work-strip[data-work-id=65849711]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849711,"title":"Brain and Central Nervous System Cancer and Benign Brain Tumors Among Chemical Plant Workers in Texas","internal_url":"https://www.academia.edu/65849711/Brain_and_Central_Nervous_System_Cancer_and_Benign_Brain_Tumors_Among_Chemical_Plant_Workers_in_Texas","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[{"id":77268293,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77268293/thumbnails/1.jpg","file_name":"6d2ad058f35f13e57fbedd92f2ab8071ed68.pdf","download_url":"https://www.academia.edu/attachments/77268293/download_file","bulk_download_file_name":"Brain_and_Central_Nervous_System_Cancer.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77268293/6d2ad058f35f13e57fbedd92f2ab8071ed68-libre.pdf?1640352888=\u0026response-content-disposition=attachment%3B+filename%3DBrain_and_Central_Nervous_System_Cancer.pdf\u0026Expires=1739852562\u0026Signature=PQNMHdWZ-FbuDdUOiiLYZSj46SPiYQSQNFgNkqSkmaCwSvameIEpgXmEk2-a6tohaP5yA1NUjhiT3zAHBArXRCA2t-TXWD-lfe7HLxRPKClx4ARU-whOdLYWOx5PRaetizXJIBpEgxp3JVsAGcLEYPn60i0Ux6y2ujODJPA01Dyf4gc-clfvXnJVNPpmALKkkfCa0vrDnSFywwXpFqzxT6mq22K1HejfQ4ikUhkY-7EdO3WqXBN8i6ZjN7tt1gzlpWTDhGeWk31nd2NNsW1CVG~8KCaJgd8CVDaO6gB60Ry4KovaOCweBLp1bKnvwUbLScCmTB4bstLPd2C8sSiPHg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849710"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/65849710/Lymphatic_and_hematopoietic_cancers_among_benzene_exposed_workers"><img alt="Research paper thumbnail of Lymphatic and hematopoietic cancers among benzene-exposed workers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/65849710/Lymphatic_and_hematopoietic_cancers_among_benzene_exposed_workers">Lymphatic and hematopoietic cancers among benzene-exposed workers</a></div><div class="wp-workCard_item"><span>Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">High benzene exposure is related to acute nonlymphocytic leukemia. Recently, myelodysplastic synd...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">High benzene exposure is related to acute nonlymphocytic leukemia. Recently, myelodysplastic syndrome has been observed at low benzene exposure levels. We updated a mortality study of workers with benzene exposure examining acute nonlymphocytic leukemia and myelodysplastic syndrome. We calculated standardized mortality ratios with 95% confidence intervals and examined latency and trends for cumulative exposure levels. All leukemias (standardized mortality ratio = 1.21; 95% confidence interval = 0.74 to 1.97) and acute non-lymphocytic leukemia (standardized mortality ratio = 1.04; 95% confidence interval = 0.34 to 2.44) were at expected levels. We observed one death from myelodysplastic syndrome (standardized mortality ratio = 6.48; 95% confidence interval = 0.17 to 38.15). We observed no trend for cumulative exposure levels. Our results for all leukemias are consistent with a small increase in risk observed in the lower-exposed subgroups of the Pliofilm study; however, our results a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849710"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849710"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849710; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849710]").text(description); $(".js-view-count[data-work-id=65849710]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849710; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849710']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65849710]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849710,"title":"Lymphatic and hematopoietic cancers among benzene-exposed workers","internal_url":"https://www.academia.edu/65849710/Lymphatic_and_hematopoietic_cancers_among_benzene_exposed_workers","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849709"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/65849709/Incomplete_follow_up_in_the_National_Cancer_Institute_s_formaldehyde_worker_study_and_the_impact_on_subsequent_reanalyses_and_causal_evaluations"><img alt="Research paper thumbnail of Incomplete follow-up in the National Cancer Institute’s formaldehyde worker study and the impact on subsequent reanalyses and causal evaluations" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/65849709/Incomplete_follow_up_in_the_National_Cancer_Institute_s_formaldehyde_worker_study_and_the_impact_on_subsequent_reanalyses_and_causal_evaluations">Incomplete follow-up in the National Cancer Institute’s formaldehyde worker study and the impact on subsequent reanalyses and causal evaluations</a></div><div class="wp-workCard_item"><span>Regulatory Toxicology and Pharmacology</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Three of us (G.M., A.Y., and P.M.) performed reanalyses of the National Cancer Institute cohort s...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Three of us (G.M., A.Y., and P.M.) performed reanalyses of the National Cancer Institute cohort study on nasopharyngeal cancer (NPC) risk among formaldehyde exposed workers (Hauptmann et al., 2004). Both reanalyses (Marsh and Youk, 2005; Marsh et al., 2007) were published in this journal. However, the mortality follow-up performed by the NCI working group reported in two publications by Hauptmann et al. (2003, 2004) was later stated to be incomplete (Beane Freeman et al., 2009a,b). This incomplete follow-up may impact the validity of the results of our reanalyses. At this time, corrected estimates for solid cancer mortality risks including NPC as reported in Hauptmann et al. (2004) have not been provided as an erratum by the authors or reported anywhere else to our knowledge. We would like to inform readers about these issues and ask for a prompt corrigendum of the 2004 publication by the NCI working group since this study has played such a prominent role in causal evaluations.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849709"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849709"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849709; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849709]").text(description); $(".js-view-count[data-work-id=65849709]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849709; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849709']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65849709]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849709,"title":"Incomplete follow-up in the National Cancer Institute’s formaldehyde worker study and the impact on subsequent reanalyses and causal evaluations","internal_url":"https://www.academia.edu/65849709/Incomplete_follow_up_in_the_National_Cancer_Institute_s_formaldehyde_worker_study_and_the_impact_on_subsequent_reanalyses_and_causal_evaluations","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849708"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849708/Cancer_dose_response_assessment_for_acrylonitrile_based_upon_rodent_brain_tumor_incidence_Use_of_epidemiologic_mechanistic_and_pharmacokinetic_support_for_nonlinearity"><img alt="Research paper thumbnail of Cancer dose–response assessment for acrylonitrile based upon rodent brain tumor incidence: Use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity" class="work-thumbnail" src="https://attachments.academia-assets.com/77268379/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849708/Cancer_dose_response_assessment_for_acrylonitrile_based_upon_rodent_brain_tumor_incidence_Use_of_epidemiologic_mechanistic_and_pharmacokinetic_support_for_nonlinearity">Cancer dose–response assessment for acrylonitrile based upon rodent brain tumor incidence: Use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity</a></div><div class="wp-workCard_item"><span>Regulatory Toxicology and Pharmacology</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A cancer dose-response assessment was conducted for acrylonitrile (AN) using updated information ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A cancer dose-response assessment was conducted for acrylonitrile (AN) using updated information on mechanism of action, epidemiology, toxicity, and pharmacokinetics. Although more than 10 chronic bioassays indicate that AN produces multiple tumors in rats and mice, a number of large, well-conducted epidemiology studies provide no evidence of a causal association between AN exposure and cancer mortality of any type. The epidemiological data include early industry exposures that are far higher than occur today and that approach or exceed levels found to be tumorigenic in animals. Despite the absence of positive Wndings in the epidemiology data, a dose-response assessment was conducted for AN based on brain tumors in rats. Mechanistic studies implicate the involvement of oxidative stress in rat brain due to a metabolite (2-cyanoethylene oxide or CEO, cyanide), but do not conclusively rule out a potential role for the direct genotoxicity of CEO. A PBPK model was used to predict internal doses (peak CEO in brain) for 12 data sets, which were pooled together to provide a consistent characterization of the dose-response relationship for brain tumor incidence in the rat. The internal dose corresponding to a 5% increase in extra risk (ED05 D 0.017 mg/L brain) and its lower conWdence limit (LED05 D 0.014 mg/L brain) was used as the point of departure. The weight-of-evidence supports the use of a nonlinear extrapolation for the cancer dose-response assessment. A quantitative comparison of the epidemiology exposure-response data (lung and brain cancer mortality) to the rat brain tumor data in terms of internal dose adds to the conWdence in the nonlinear extrapolation. Uncertainty factors of 200 and 220 (for the oral and inhalation routes, respectively) were applied to the LED05 to account for interspecies variation, intraspecies variation, and the severity of the response measure. Accordingly, oral doses below 0.009 mg/kg-day and air concentrations below 0.1 mg/m 3 are not expected to pose an appreciable risk to human populations exposed to AN.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ee67781bdd325ed8605b30ba6d0f83af" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268379,"asset_id":65849708,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268379/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849708"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849708"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849708; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849708]").text(description); $(".js-view-count[data-work-id=65849708]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849708; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849708']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ee67781bdd325ed8605b30ba6d0f83af" } } $('.js-work-strip[data-work-id=65849708]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849708,"title":"Cancer dose–response assessment for acrylonitrile based upon rodent brain tumor incidence: Use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity","internal_url":"https://www.academia.edu/65849708/Cancer_dose_response_assessment_for_acrylonitrile_based_upon_rodent_brain_tumor_incidence_Use_of_epidemiologic_mechanistic_and_pharmacokinetic_support_for_nonlinearity","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[{"id":77268379,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77268379/thumbnails/1.jpg","file_name":"j.yrtph.2005.06.00720211224-24339-1adko01.pdf","download_url":"https://www.academia.edu/attachments/77268379/download_file","bulk_download_file_name":"Cancer_dose_response_assessment_for_acry.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77268379/j.yrtph.2005.06.00720211224-24339-1adko01-libre.pdf?1640352884=\u0026response-content-disposition=attachment%3B+filename%3DCancer_dose_response_assessment_for_acry.pdf\u0026Expires=1739852562\u0026Signature=aw6OetxE8iOVT1d8aOKaB0y8f67kfBsyP1ByiSsBQrQ8ZnT4D7vEplFKnsxi2BDzr08v2MpEaD5ovbgupTaaH5Zfe7ShAPZb~sEoXlSmWF5GIQgVOVgS-qlrV6ncJUevVdWqzT9sx7ce7mWKmnbyejtMvmyfLZVrVjjIxc-aA5UqQF0sk8fbCi2yBXJp9x5XjGCetOc~lJ2hwz3ACTMf6CIwQjOAxcY4gCIHf1Jf3UnYSUZrE~MCB7PQofgyQYDkYHADd9d75Nwiy8PHYDPq2Woj9yA9u5UPHrT5dztVQ5TnIbf2rz1RV1yDbyLtNU1f0e~rSQaYcER1Oykt1K5OoA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849706"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849706/Issues_of_methods_and_interpretation_in_the_National_Cancer_Institute_formaldehyde_cohort_study"><img alt="Research paper thumbnail of Issues of methods and interpretation in the National Cancer Institute formaldehyde cohort study" class="work-thumbnail" src="https://attachments.academia-assets.com/77268304/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849706/Issues_of_methods_and_interpretation_in_the_National_Cancer_Institute_formaldehyde_cohort_study">Issues of methods and interpretation in the National Cancer Institute formaldehyde cohort study</a></div><div class="wp-workCard_item"><span>Journal of Occupational Medicine and Toxicology</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In 2004, the International Agency for Research on Cancer (IARC) reclassified formaldehyde (FA) fr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In 2004, the International Agency for Research on Cancer (IARC) reclassified formaldehyde (FA) from a probable (Group 2A) to a known human carcinogen (Group 1) citing results for nasopharyngeal cancer (NPC) mortality from the follow-up through 1994 of the National Cancer Institute formaldehyde cohort study. To the contrary, in 2012, the Committee for Risk Assessment of the European Chemicals Agency disagreed with the proposal to classify FA as a known human carcinogen (Carc. 1A), proposing a lower but still protective category, namely as a substance which is presumed to have carcinogenic potential for humans (Carc. 1B). Thus, U.S. and European regulatory agencies currently disagree about the potential human carcinogenicity of FA. In 2013, the National Cancer Institute reported results from their follow-up through 2004 of the formaldehyde cohort and concluded that the results continue to suggest a link between FA exposure and NPC. We discuss in this commentary why we believe that this interpretation is neither consistent with the available data from the most recent update of the National Cancer Institute cohort study nor with other research findings from that cohort, other large cohort studies and the series of publications by some of the current authors, including an independent study of one of the National Cancer Institute's study plants. Another serious concern relates to the incorrectness of the data from the follow-up through 1994 of the National Cancer Institute study stemming from incomplete mortality ascertainment. While these data were corrected by the National Cancer Institute in subsequent supplemental publications, incorrect data from the original publications have been cited extensively in recent causal evaluations of FA, including IARC. We conclude that the NCI publications that contain incorrect data from the incomplete 1994 mortality follow-up should be retracted entirely or corrected via published errata in the corresponding journals, and efforts should be made to re-analyze data from the 2004 follow-up of the NCI cohort study.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d09530b722360596368a83bc6b74641e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268304,"asset_id":65849706,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268304/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849706"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849706"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849706; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849706]").text(description); $(".js-view-count[data-work-id=65849706]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849706; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849706']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d09530b722360596368a83bc6b74641e" } } $('.js-work-strip[data-work-id=65849706]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849706,"title":"Issues of methods and interpretation in the National Cancer Institute formaldehyde cohort study","internal_url":"https://www.academia.edu/65849706/Issues_of_methods_and_interpretation_in_the_National_Cancer_Institute_formaldehyde_cohort_study","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[{"id":77268304,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77268304/thumbnails/1.jpg","file_name":"1745-6673-9-22.pdf","download_url":"https://www.academia.edu/attachments/77268304/download_file","bulk_download_file_name":"Issues_of_methods_and_interpretation_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77268304/1745-6673-9-22-libre.pdf?1640352889=\u0026response-content-disposition=attachment%3B+filename%3DIssues_of_methods_and_interpretation_in.pdf\u0026Expires=1739852562\u0026Signature=TsxRB2-ALyODrf~gk~tk8DS-iamJ7wByfGPeOqr7bc~GW7fkkJmOmGFR7SKVtk~wyh-KB7lSYgCWZJdIpj43enDxZz-n6cQmTyKBpo24kJhSrmjeUGMEkU1~vLG6sLuotAnr5ReEr5PIIV3FfypNV38rOgBwQ7qJTtYqyK9XvZQ8cMTtIaTow7Rp4dSPjuP4zaJIRDAVdqUoX9rL5Slj9Ztt0NvMmIsI4rtQiedPurUULw5V7EJY-Ibi8oNAAK2M8BNCYp4cwscpawjmn3IrUZK5KRSG0HEGvOSHkTTT7oZETXOSsrjSIDRF-yfVayLsgAW~Im~b0V4Ek4LQG415ug__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849704"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849704/Cancer_risk_for_chemical_workers_exposed_to_2_3_7_8_tetrachlorodibenzo_p_dioxin"><img alt="Research paper thumbnail of Cancer risk for chemical workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin" class="work-thumbnail" src="https://attachments.academia-assets.com/77268302/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849704/Cancer_risk_for_chemical_workers_exposed_to_2_3_7_8_tetrachlorodibenzo_p_dioxin">Cancer risk for chemical workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin</a></div><div class="wp-workCard_item"><span>Occupational and Environmental Medicine</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aims: To describe the long term mortality experience of a cohort of 2187 male chemical production...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aims: To describe the long term mortality experience of a cohort of 2187 male chemical production workers previously exposed to substantial levels of dioxin. Methods: Vital status for a previously identified cohort was determined for an additional 10 years, to 1995. Dioxin exposures took place before 1983 and were sufficient to result in chloracne in 245 individuals. Mortality rates were compared with national figures and with a large pool of co-workers in unrelated production jobs. Results: All cancers combined (standardised mortality ratio (SMR) = 1.0, 95% CI 0.8 to 1.1) and lung cancer (SMR = 0.8, 95% CI 0.6 to 1.1) were at or below expected levels. Rates for soft tissue sarcoma (SMR = 2.4, 95% CI 0.3 to 8.6) and non-Hodgkin's lymphoma (SMR = 1.4, 95% CI 0.6 to 2.7) were greater than expected overall, but below expectation in the update period. No trend of increasing risk with increasing exposure was observed for these cancers. Workers who developed chloracne had very low all-cancer rates (SMR = 0.5, 95% CI 0.3 to 1.0), and lung cancer rates (SMR = 0.3, 95% CI 0.0 to 1.1). Conclusions: We found no coherent evidence of increased cancer risk from dioxin exposure in this cohort. Our study highlights the wide range of cancer rates and the lack of consistency across dioxin studies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="19583e1cc549c72b7a5d2957ff474c64" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268302,"asset_id":65849704,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268302/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849704"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849704"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849704; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849704]").text(description); $(".js-view-count[data-work-id=65849704]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849704; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849704']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "19583e1cc549c72b7a5d2957ff474c64" } } $('.js-work-strip[data-work-id=65849704]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849704,"title":"Cancer risk for chemical workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin","internal_url":"https://www.academia.edu/65849704/Cancer_risk_for_chemical_workers_exposed_to_2_3_7_8_tetrachlorodibenzo_p_dioxin","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[{"id":77268302,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77268302/thumbnails/1.jpg","file_name":"fda1abab26cd015a4cfc866d8b8b9006e91e.pdf","download_url":"https://www.academia.edu/attachments/77268302/download_file","bulk_download_file_name":"Cancer_risk_for_chemical_workers_exposed.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77268302/fda1abab26cd015a4cfc866d8b8b9006e91e-libre.pdf?1640352888=\u0026response-content-disposition=attachment%3B+filename%3DCancer_risk_for_chemical_workers_exposed.pdf\u0026Expires=1739852562\u0026Signature=GTU3g3qQbEsX0KPw8CpOIPVtH8WFHEw2JYEQueTw-L2LkCzU3RGXzknHrTwztWsqqCt0JxTdQjbFLFtRunVdZY0tLZbfgdTEj26cRW-MHyURZLMnRKPAX8fAbVyR6vcGB23ixRXZcua2kpMFF-95SPSTmn2Y6iu-EqtVqhH9HtiNIbCV2~PfeqKtvfb5dAF6p3QJzI~w9VXQeSbIlAhw7mIIJ6bgPC0qPjAPgZo0eLMWJp49EJB9KKq5xiQG-LUN3JAGX5pP~PhXp1mhXZmcVZsE5bRY6ckPRuHRRJ4CSard8Y-43wpqBPYj~1LuGMc9sS6LYlEec989F1ZibuF7IA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849702"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849702/Reevaluation_of_lung_cancer_risk_in_the_acrylonitrile_cohort_study_of_the_National_Cancer_Institute_and_the_National_Institute_for_Occupational_Safety_and_Health"><img alt="Research paper thumbnail of Reevaluation of lung cancer risk in the acrylonitrile cohort study of the National Cancer Institute and the National Institute for Occupational Safety and Health" class="work-thumbnail" src="https://attachments.academia-assets.com/77268471/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849702/Reevaluation_of_lung_cancer_risk_in_the_acrylonitrile_cohort_study_of_the_National_Cancer_Institute_and_the_National_Institute_for_Occupational_Safety_and_Health">Reevaluation of lung cancer risk in the acrylonitrile cohort study of the National Cancer Institute and the National Institute for Occupational Safety and Health</a></div><div class="wp-workCard_item"><span>Scandinavian Journal of Work, Environment & Health</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objectives The present study provides additional analyses of data obtained earlier on lung cancer...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objectives The present study provides additional analyses of data obtained earlier on lung cancer risk among workers with acrylonitrile exposure. Methods The original authors provided the data. For total mortality and the cancer sites of a priori interest (lung, stomach, brain, breast, prostate, and the lymphatic and hematopoietic systems), standardized mortality ratios (SMR) and 95% confidence intervals (95% CI) were computed, the total United States and surrounding counties being used as standard populations. Regional rate-based SMR values were also computed between lung cancer and cumulative acrylonitrile exposure. Results Except for lung cancer, the external comparisons corroborated the earlier internal comparisons (no increased cancer mortality risk). For lung cancer, the external comparisons revealed death deficits for the unexposed workers (SMR 0.68, 95% CI 0.5-0.9) and all categories of acrylonitrile-exposed workers. The SMR obtained using external rates and the most exposed group (SMR 0.92, 95% CI 0.6-1.4) differed from the corresponding relative risk (RR) of the internal rates (RR 1.5, 95% CI 0.9-2.4). Conclusions The analysis of the present study provides little evidence that acrylonitrile exposure increases the mortality risk of cancers of a priori interest, including lung cancer. The lung cancer findings of the external comparison differed from the earlier findings of the internal comparisons. Selection bias (as the healthy worker effect) was probably not responsible. Additional follow-up and analyses, especially of the unexposed workers with low lung cancer rates, may help elucidate the internal and external comparison differences. Results from both comparisons should be presented when the relative risks differ markedly, as both have advantages and disadvantages.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1c8abd555ccc98795ff097308b066a4c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268471,"asset_id":65849702,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268471/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849702"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849702"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849702; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849702]").text(description); $(".js-view-count[data-work-id=65849702]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849702; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849702']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1c8abd555ccc98795ff097308b066a4c" } } $('.js-work-strip[data-work-id=65849702]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849702,"title":"Reevaluation of lung cancer risk in the acrylonitrile cohort study of the National Cancer Institute and the National Institute for Occupational Safety and Health","internal_url":"https://www.academia.edu/65849702/Reevaluation_of_lung_cancer_risk_in_the_acrylonitrile_cohort_study_of_the_National_Cancer_Institute_and_the_National_Institute_for_Occupational_Safety_and_Health","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[{"id":77268471,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77268471/thumbnails/1.jpg","file_name":"download.pdf","download_url":"https://www.academia.edu/attachments/77268471/download_file","bulk_download_file_name":"Reevaluation_of_lung_cancer_risk_in_the.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77268471/download-libre.pdf?1640352912=\u0026response-content-disposition=attachment%3B+filename%3DReevaluation_of_lung_cancer_risk_in_the.pdf\u0026Expires=1739852562\u0026Signature=cTQEnb~sbLVpqnakI-SADRXzAgVnrO-ubettDYyu5ESBr8ataoE4BT4T2E9z5aBBiLGKVQlda5GzWgD1iwGGfQej5mNOAWwrzxNYnRIxEHwz6~l1yQBV3U28Drl7uo4U1Pr~KJZR9KyTBYVei6eGqXoW2VlJhun3T6FseYOUdOTQ2syIkdgUdrgCQd-PezU2KtwsSwrYKpd3L8iyuR4N4Wto3kO3vPWDnrb4vvX2qqIUh5OqzAX~4Nyrb~BUJhqYcU7xH004SSj6QzjgItXlMq5Y1pwBQ3xlJdr~~uzMr~sVyTpBvO6y1Ab6AFIF~8UfQuCL2NqdGZ4IyOu1k4nvsw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849700"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/65849700/A_Risk_Assessment_for_Occupational_Acrylonitrile_Exposure_Using_Epidemiology_Data"><img alt="Research paper thumbnail of A Risk Assessment for Occupational Acrylonitrile Exposure Using Epidemiology Data" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/65849700/A_Risk_Assessment_for_Occupational_Acrylonitrile_Exposure_Using_Epidemiology_Data">A Risk Assessment for Occupational Acrylonitrile Exposure Using Epidemiology Data</a></div><div class="wp-workCard_item"><span>Risk Analysis</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The extensive data from the Blair et al.((1)) epidemiology study of occupational acrylonitrile ex...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The extensive data from the Blair et al.((1)) epidemiology study of occupational acrylonitrile exposure among 25460 workers in eight plants in the United States provide an excellent opportunity to update quantitative risk assessments for this widely used commodity chemical. We employ the semiparametric Cox relative risk (RR) regression model with a cumulative exposure metric to model cause-specific mortality from lung cancer and all other causes. The separately estimated cause-specific cumulative hazards are then combined to provide an overall estimate of age-specific mortality risk. Age-specific estimates of the additional risk of lung cancer mortality associated with several plausible occupational exposure scenarios are obtained. For age 70, these estimates are all markedly lower than those generated with the cancer potency estimate provided in the USEPA acrylonitrile risk assessment.((2)) This result is consistent with the failure of recent occupational studies to confirm elevated lung cancer mortality among acrylonitrile-exposed workers as was originally reported by O&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;Berg,((3)) and it calls attention to the importance of using high-quality epidemiology data in the risk assessment process.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849700"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849700"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849700; 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This paper responds to that call by demonstrating a distributional approach that draws upon human data to derive potency estimates and to identify and quantify important sources of uncertainty. The approach is rooted in the science of decision analysis and employs an influence diagram, a decision tree, probabilistic weights, and a distribution of point estimates of carcinogenic potency. Its results estimate the likelihood of different carcinogenic risks (potencies) for a chemical under a specific scenario. For this exercise, human data on formaldehyde were employed to demonstrate the approach. Sensitivity analyses were performed to determine the relative impact of specific levels and alternatives on the potency distribution. The resulting potency estimates are compared with the results of an exercise using animal data on formaldehyde. The paper demonstrates that distributional risk assessment is readily adapted to situations in which epidemiologic data serve as the basis for potency estimates. Strengths and weaknesses of the distributional approach are discussed. Areas for further application and research are recommended.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cdc7a10bf4ea1fe5dfd576a416060773" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268312,"asset_id":65849698,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268312/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849698"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849698"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849698; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cdc7a10bf4ea1fe5dfd576a416060773" } } $('.js-work-strip[data-work-id=65849698]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849698,"title":"Quantifying Uncertainty in a Risk Assessment Using Human Data","internal_url":"https://www.academia.edu/65849698/Quantifying_Uncertainty_in_a_Risk_Assessment_Using_Human_Data","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[{"id":77268312,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77268312/thumbnails/1.jpg","file_name":"a_3A100702651019820211224-24336-u427w3.pdf","download_url":"https://www.academia.edu/attachments/77268312/download_file","bulk_download_file_name":"Quantifying_Uncertainty_in_a_Risk_Assess.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77268312/a_3A100702651019820211224-24336-u427w3-libre.pdf?1640352887=\u0026response-content-disposition=attachment%3B+filename%3DQuantifying_Uncertainty_in_a_Risk_Assess.pdf\u0026Expires=1739852562\u0026Signature=YoINgj4TLQPtRtNvSsNgX2xbVzTgGlDTV1O6-3CD7TJ5yw1XnD23SnLOx8CnM4Hm3eR4JK5vnRKI3mc4yxPFSFVhgM4AIgRmy-tXAffY-uFY~jyTYFizSg3W7yJD4hfV74OVHIs3Pw-HR2KoJK8WXcDRRyZ4b3FFGdqZNw29Rt33N-sEx78O2saQQAYsciKf2myKlAkTfmCkMQo3s4kFt9v8C~Cvmd-ay4N0If68olmuSf61GyiCAv-05KvOC2PERrKr~wZro0he7nOYjv9pIiaTKTMfU47Gb8JD1ilMjXeo98l2606c7PmA-8AesSl~ftPBRvg0MH04QaMsk5m3EQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849695"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849695/Evaluating_emerging_issues_in_epidemiology"><img alt="Research paper thumbnail of Evaluating emerging issues in epidemiology" class="work-thumbnail" src="https://attachments.academia-assets.com/77268378/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849695/Evaluating_emerging_issues_in_epidemiology">Evaluating emerging issues in epidemiology</a></div><div class="wp-workCard_item"><span>Regulatory Toxicology and Pharmacology</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Industry and government institutions need a credible approach for evaluating and responding to em...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Industry and government institutions need a credible approach for evaluating and responding to emerging public health issues. Representatives of industry, government, and academia met under the auspices of the International Life Sciences Institute's Health and Environmental Sciences Institute (HESI) to develop successful strategies for dealing with emerging issues based on historical case studies. The case studies chosen for evaluation were (1) tampon use and toxic shock syndrome; (2) hazardous waste and childhood cancer risk in Toms River, New Jersey; (3) fenfluramine and phentermine use and valvular heart disease; (4) silicone breast implants and cancer and auto-immune disease; and (5) progestational drugs and birth defects. We identified eight lessons from these case studies. Foremost, we recommend that public and private institutions not defer action until an issue is scientifically resolved and stress that cooperation among issue stakeholders is critical for effective issue resolution. We suggest establishing a research program as an effective way to assure that good science is included in resolution of the issue. We further recommend frequent and timely communication with all stakeholders, and the development of research approaches to fill gaps when the scientific data on an issue are limited.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="57c12c4a01bf8bea532c38376a841e6b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268378,"asset_id":65849695,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268378/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849695"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849695"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849695; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849693"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/65849693/The_healthy_worker_effect_in_US_chemical_industry_workers"><img alt="Research paper thumbnail of The healthy worker effect in US chemical industry workers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/65849693/The_healthy_worker_effect_in_US_chemical_industry_workers">The healthy worker effect in US chemical industry workers</a></div><div class="wp-workCard_item"><span>Occupational Medicine</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Occupational studies typically observe a 20% deficit in overall mortality, broadly characterized ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Occupational studies typically observe a 20% deficit in overall mortality, broadly characterized as the healthy worker effect (HWE). Components of the HWE may be addressed by various analytical approaches. To explore the HWE in a modern industrial cohort. Standardized mortality ratios (SMRs) were calculated for 114,683 US chemical industry employees, who worked at least 3 days between 1960 and 2005. SMRs were 79 (95% confidence interval 78-80) for all causes, 81 (95% confidence interval 79-82) for heart disease, 70 (95% confidence interval 67-73) for non-malignant respiratory disease, 83 (95% confidence interval 81-85) for smoking-related cancers (buccal, cervix, oesophagus, stomach, pancreas, lung, larynx, bladder and kidney) combined and 97 (95% confidence interval 95-100) for other cancers. The low SMRs observed in this study are likely due to differential smoking between the cohort and the background population. Future considerations to control for the HWE should take this into account.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849693"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849693"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849693; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849693]").text(description); $(".js-view-count[data-work-id=65849693]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849693; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849693']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65849693]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849693,"title":"The healthy worker effect in US chemical industry workers","internal_url":"https://www.academia.edu/65849693/The_healthy_worker_effect_in_US_chemical_industry_workers","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849691"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849691/Slips_trips_and_falls_at_a_chemical_manufacturing_company"><img alt="Research paper thumbnail of Slips, trips and falls at a chemical manufacturing company" class="work-thumbnail" src="https://attachments.academia-assets.com/77268299/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849691/Slips_trips_and_falls_at_a_chemical_manufacturing_company">Slips, trips and falls at a chemical manufacturing company</a></div><div class="wp-workCard_item"><span>Occupational Medicine</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background Slips, trips and falls (STF) are a major cause of workplace injury. Aims To examine ri...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background Slips, trips and falls (STF) are a major cause of workplace injury. Aims To examine risk factors for STF at a large US chemical manufacturing company. Methods We conducted a case-control study of occupational STF. Cases were identified from company injury records between 1 April 2009 and 1 May 2011. Four controls per case were randomly selected from all active company workers employed during the same time. Data were collected through a questionnaire and from company medical examinations. Logistic regression was used to calculate odds ratio (OR) and 95% confidence intervals (95% CI) for personal, environmental and health-related risk factors for STF. Results There were 74 cases and 309 controls. The response rate was 65% for the cases and 68% for the controls. Most STF were unrelated to production activities. When examining all factors in a logistic regression model, increased OR were observed for increased body mass index (OR = 1.44, 95% CI: 1.03-2.02), having arthritis (OR = 2.11, 95% CI: 1.01-4.37), lack of exercise (OR = 2.25, 95% CI: 1.01-5.05), carrying materials (OR = 3.01, 95% CI: 1.41-6.43) and being female (OR = 2.46, 95% CI: 1.17-5.19). Reduced risk of STF was observed for never having smoked (OR = 0.48, 95% CI: 0.24-0.95), long service (OR = 0.53, 95% CI: 0.34-0.81) and persons working over 8 h a day (OR = 0.42, 95% CI: 0.20-0.88). Conclusions Risk factors for STF in a large US chemical company are similar to those reported from other workplaces, but we found that staying fit and healthy is important for reducing risk.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2e74d7c938c7c56bc0a21248643db937" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268299,"asset_id":65849691,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268299/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849691"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849691"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849691; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849691]").text(description); $(".js-view-count[data-work-id=65849691]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849691; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849691']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849689"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/65849689/Mortality_study_update_of_acrylamide_workers"><img alt="Research paper thumbnail of Mortality study update of acrylamide workers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/65849689/Mortality_study_update_of_acrylamide_workers">Mortality study update of acrylamide workers</a></div><div class="wp-workCard_item"><span>Occupational and Environmental Medicine</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The authors examined the long-term health effects of occupational exposure to acrylamide among pr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The authors examined the long-term health effects of occupational exposure to acrylamide among production and polymerisation workers. An earlier study of 371 acrylamide workers was expanded to include employees hired since 1979. In this updated study, 696 acrylamide workers were followed from 1955 through 2001 to ascertain vital status and cause of death. Exposure to acrylamide was retrospectively assessed based on personal samples from the 1970s onwards and area samples over the whole study period. Fewer of the acrylamide workers died (n = 141) compared to an expected number of 172.1 (SMR 81.9, 95% CI 69.0 to 96.6). No cause-specific SMR for any of the investigated types of cancer was exposure related. The authors did, however, find more pancreatic cancer deaths than expected (SMR 222.2, 95% CI 72.1 to 518.5). With respect to non-malignant disease, more diabetes deaths were observed than expected (SMR 288.7, 95% CI 138.4 to 531.0). To assess the influence of regional factors, the analysis was repeated with an internal reference population. The elevated SMR for diabetes persisted. This study provides little evidence for a cancer risk from occupational exposure to acrylamide at production facilities. However, the increased rates of pancreatic cancer in this study and another larger study of acrylamide production workers indicate that caution is needed to rule out a cancer risk. The authors believe that the excess of diabetes mortality in this study is most likely not related to acrylamide exposure, because a larger study of acrylamide workers reported a deficit in this cause of death. The authors conclude that the increased SMR for diabetes mortality is probably not related to regional influences.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849689"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849689"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849689; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849689]").text(description); 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window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=71692473]").text(description); $(".js-view-count[data-work-id=71692473]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 71692473; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='71692473']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=71692473]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":71692473,"title":"Elimination Rates of Dioxin Congeners in Former Chlorophenol Workers from Midland, Michigan","internal_url":"https://www.academia.edu/71692473/Elimination_Rates_of_Dioxin_Congeners_in_Former_Chlorophenol_Workers_from_Midland_Michigan","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849717"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849717/Cohort_study_of_workers_at_a_New_Zealand_agrochemical_plant_to_assess_the_effect_of_dioxin_exposure_on_mortality"><img alt="Research paper thumbnail of Cohort study of workers at a New Zealand agrochemical plant to assess the effect of dioxin exposure on mortality" class="work-thumbnail" src="https://attachments.academia-assets.com/77268294/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849717/Cohort_study_of_workers_at_a_New_Zealand_agrochemical_plant_to_assess_the_effect_of_dioxin_exposure_on_mortality">Cohort study of workers at a New Zealand agrochemical plant to assess the effect of dioxin exposure on mortality</a></div><div class="wp-workCard_item"><span>BMJ open</span><span>, Jan 17, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To describe how the exposure to 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD) influenced mortality in...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To describe how the exposure to 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD) influenced mortality in a cohort of workers who were exposed more recently, and at lower levels, than other cohorts of trichlorophenol process workers. A cohort study. An agrochemical plant in New Zealand PARTICIPANTS: 1,599 men and women working between 1 January 1969 and 1 November 1988 at a plant producing the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) with TCDD as a contaminant. Cumulative TCDD exposure was estimated for each individual in the study by a toxicokinetic model. Calculation of cause-specific standardised mortality ratios (SMRs) and 95% confidence intervals (95% CI&#39;s) compared those never and ever exposed to TCDD. Dose-response trends were assessed firstly through SMRs stratified in quartiles of cumulative TCCD exposure, and secondly with a proportional hazards model. The model intercept of 5.1 ppt of TCDD was consistent with background TCDD concentrations in New Zealand among ol...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a67d7ef840513773d110c7b21a8d4d0f" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268294,"asset_id":65849717,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268294/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849717"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849717"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849717; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849716"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849716/A_systematic_review_of_epidemiologic_studies_of_styrene_and_cancer"><img alt="Research paper thumbnail of A systematic review of epidemiologic studies of styrene and cancer" class="work-thumbnail" src="https://attachments.academia-assets.com/77268305/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849716/A_systematic_review_of_epidemiologic_studies_of_styrene_and_cancer">A systematic review of epidemiologic studies of styrene and cancer</a></div><div class="wp-workCard_item"><span>Critical reviews in toxicology</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Previous epidemiology reviews of exposure to styrene and the risk of cancer considered studies pu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Previous epidemiology reviews of exposure to styrene and the risk of cancer considered studies published through 13 November 2013. Since then, additional relevant research has been published. No review has included meta-analyses. The current systematic review considered research published through June 2017; included meta-analyses of the relationship between any exposure to styrene and cancers identified as being of concern, including non-Hodgkin lymphoma (NHL), leukemia and cancers of the esophagus, pancreas, lung and kidney; and evaluated several other forms of cancer. Meta-relative risks for all studies were 1.14 (95% confidence interval (CI), 0.91-1.43) for NHL, 1.00 (95% CI, 0.80-1.26) for multiple myeloma, 0.98 (95% CI, 0.87-1.09) for all leukemia, 1.03 (95% CI, 0.92-1.15) for esophageal cancer, 1.02 (95% CI, 0.93-1.12) for pancreatic cancer, 1.09 (95% CI, 0.95-1.24) for lung cancer and 1.10 (95% CI, 0.99-1.22) for kidney cancer. Individual studies provided little evidence of e...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e9d9da5ce51987ca71c69be51cea8714" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268305,"asset_id":65849716,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268305/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849716"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849716"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849716; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849715"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849715/Incidence_of_Occupational_Asthma_and_Exposure_to_Toluene_Diisocyanate_in_the_United_States_Toluene_Diisocyanate_Production_Industry"><img alt="Research paper thumbnail of Incidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry" class="work-thumbnail" src="https://attachments.academia-assets.com/77268307/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849715/Incidence_of_Occupational_Asthma_and_Exposure_to_Toluene_Diisocyanate_in_the_United_States_Toluene_Diisocyanate_Production_Industry">Incidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry</a></div><div class="wp-workCard_item"><span>Journal of occupational and environmental medicine</span><span>, 2017</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This study examines asthma risk in facilities producing toluene diisocyanate (TDI). A total of 19...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This study examines asthma risk in facilities producing toluene diisocyanate (TDI). A total of 197 workers were monitored from 2007 to 2012. TDI air concentrations were used to estimate exposures. The incidence of cases consistent with TDI-induced asthma was 0.009 per person-years (seven cases) or consistent with TDI-induced asthma or asthma indeterminate regarding work-relatedness was 0.012 (nine cases). Increased risk of cases consistent with TDI asthma was observed for cumulative (odds ratio [OR] = 2.08, 95% confidence interval [CI] 1.07 to 4.05) per logarithm parts per billion-years and peak TDI exposures (OR = 1.18, 95% CI 1.06 to 1.32) (logarithm parts per billion). There was a weak association with cumulative and peak exposures for decline of short-term forced expiratory volume in one second (FEV1). Asthma symptoms were associated with workers noticing an odor of TDI (OR 6.02; 95% CI 1.36 to 26.68). There is evidence that cumulative and peak exposures are associated with TDI-...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7394700b2598f974a4bcf97d06af05ce" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268307,"asset_id":65849715,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268307/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849715"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849715"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849715; 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</script> <div class="js-work-strip profile--work_container" data-work-id="65849713"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849713/Cancer_risk_for_chemical_workers_exposed_to_2_3_7_8_tetrachlorodibenzo_p_dioxin"><img alt="Research paper thumbnail of Cancer risk for chemical workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin" class="work-thumbnail" src="https://attachments.academia-assets.com/77268306/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849713/Cancer_risk_for_chemical_workers_exposed_to_2_3_7_8_tetrachlorodibenzo_p_dioxin">Cancer risk for chemical workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin</a></div><div class="wp-workCard_item"><span>Occupational and environmental medicine</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To describe the long term mortality experience of a cohort of 2187 male chemical production worke...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To describe the long term mortality experience of a cohort of 2187 male chemical production workers previously exposed to substantial levels of dioxin. Vital status for a previously identified cohort was determined for an additional 10 years, to 1995. Dioxin exposures took place before 1983 and were sufficient to result in chloracne in 245 individuals. Mortality rates were compared with national figures and with a large pool of co-workers in unrelated production jobs. All cancers combined (standardised mortality ratio (SMR) = 1.0, 95% CI 0.8 to 1.1) and lung cancer (SMR = 0.8, 95% CI 0.6 to 1.1) were at or below expected levels. Rates for soft tissue sarcoma (SMR = 2.4, 95% CI 0.3 to 8.6) and non-Hodgkin&#39;s lymphoma (SMR = 1.4, 95% CI 0.6 to 2.7) were greater than expected overall, but below expectation in the update period. No trend of increasing risk with increasing exposure was observed for these cancers. Workers who developed chloracne had very low all-cancer rates (SMR = 0.5...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="046c374e57d22606a1039a268e4c8539" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268306,"asset_id":65849713,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268306/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849713"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849713"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849713; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "046c374e57d22606a1039a268e4c8539" } } $('.js-work-strip[data-work-id=65849713]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849713,"title":"Cancer risk for chemical workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin","internal_url":"https://www.academia.edu/65849713/Cancer_risk_for_chemical_workers_exposed_to_2_3_7_8_tetrachlorodibenzo_p_dioxin","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[{"id":77268306,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77268306/thumbnails/1.jpg","file_name":"fda1abab26cd015a4cfc866d8b8b9006e91e.pdf","download_url":"https://www.academia.edu/attachments/77268306/download_file","bulk_download_file_name":"Cancer_risk_for_chemical_workers_exposed.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77268306/fda1abab26cd015a4cfc866d8b8b9006e91e-libre.pdf?1640352887=\u0026response-content-disposition=attachment%3B+filename%3DCancer_risk_for_chemical_workers_exposed.pdf\u0026Expires=1739852562\u0026Signature=HgFpVatzIwgB9e9H~zEpzrzwIM-8mRmtt0m8QXRli0aONQxcBrfumsEahX~h-XvqcJijoj2DCjKZmqhSmbd3I1uebe1-yYjfqd5izneklNazLyVsDSyCWuk2WwUDujMBiQTTWXDfUkM5s3CU32YizMrPKKx-zwtlOQzEyjfspF9ATFwjwuhBwnudNfTauoCy5I6NNcJicBBDR-yLci2JHgTbTSg~0MvYQ8iEHMvWsLLvhQE~LVB3mGHXEDlkNn9JyTSITrvaGhAmoojh5U~BbK7dvUfnQrO4RQs-cAZHJvgndDwcNIXmPyj38sdhTXL96GpHSh4vdekoClKnuENJRw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849712"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/65849712/Re_Respiratory_and_irritant_health_effects_of_ambient_volatile_organic_compounds_the_Kanawha_County_Health_Study"><img alt="Research paper thumbnail of Re: Respiratory and irritant health effects of ambient volatile organic compounds: the Kanawha County Health Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/65849712/Re_Respiratory_and_irritant_health_effects_of_ambient_volatile_organic_compounds_the_Kanawha_County_Health_Study">Re: Respiratory and irritant health effects of ambient volatile organic compounds: the Kanawha County Health Study</a></div><div class="wp-workCard_item"><span>American journal of epidemiology</span><span>, Jan 15, 1995</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849712"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849712"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849712; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849712]").text(description); $(".js-view-count[data-work-id=65849712]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849712; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849712']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65849712]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849712,"title":"Re: Respiratory and irritant health effects of ambient volatile organic compounds: the Kanawha County Health Study","internal_url":"https://www.academia.edu/65849712/Re_Respiratory_and_irritant_health_effects_of_ambient_volatile_organic_compounds_the_Kanawha_County_Health_Study","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849711"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849711/Brain_and_Central_Nervous_System_Cancer_and_Benign_Brain_Tumors_Among_Chemical_Plant_Workers_in_Texas"><img alt="Research paper thumbnail of Brain and Central Nervous System Cancer and Benign Brain Tumors Among Chemical Plant Workers in Texas" class="work-thumbnail" src="https://attachments.academia-assets.com/77268293/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849711/Brain_and_Central_Nervous_System_Cancer_and_Benign_Brain_Tumors_Among_Chemical_Plant_Workers_in_Texas">Brain and Central Nervous System Cancer and Benign Brain Tumors Among Chemical Plant Workers in Texas</a></div><div class="wp-workCard_item"><span>The Open Epidemiology Journal</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the early 1980's, a clustering of brain and central nervous system cancers was observed among ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the early 1980's, a clustering of brain and central nervous system cancers was observed among workers at a Texas City, Texas chemical plant. A series of studies with follow-up from 1941 to 1983 failed to identify an occupational cause. We added women and newly hired workers to these studies and expanded the follow-up from 1940 to 2001 using a retrospective cohort mortality design. The SMR for brain and central nervous system cancers was slightly less than expected (SMR=0.93, 95% CI 0.60-1.38) whereas the SMR for benign brain tumors was slightly greater than expected (SMR=1.50, 95% CI 0.72-2.76) during the entire observation period. SMRs were close to expected levels when examining sex, wage type, year of hire, years of latency, and duration of employment for these causes. We observed high rates of brain and central nervous system cancers from 1970 to 1984 but lower rates in the other periods. We conclude that the excess cancer and tumor mortality reported in the earlier studies may be a random cluster and unrelated to workplace exposures.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eb9341c91b1057c83e9ca26bace7248e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268293,"asset_id":65849711,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268293/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849711"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849711"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849711; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849711]").text(description); $(".js-view-count[data-work-id=65849711]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849711; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849711']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "eb9341c91b1057c83e9ca26bace7248e" } } $('.js-work-strip[data-work-id=65849711]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849711,"title":"Brain and Central Nervous System Cancer and Benign Brain Tumors Among Chemical Plant Workers in Texas","internal_url":"https://www.academia.edu/65849711/Brain_and_Central_Nervous_System_Cancer_and_Benign_Brain_Tumors_Among_Chemical_Plant_Workers_in_Texas","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[{"id":77268293,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77268293/thumbnails/1.jpg","file_name":"6d2ad058f35f13e57fbedd92f2ab8071ed68.pdf","download_url":"https://www.academia.edu/attachments/77268293/download_file","bulk_download_file_name":"Brain_and_Central_Nervous_System_Cancer.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77268293/6d2ad058f35f13e57fbedd92f2ab8071ed68-libre.pdf?1640352888=\u0026response-content-disposition=attachment%3B+filename%3DBrain_and_Central_Nervous_System_Cancer.pdf\u0026Expires=1739852562\u0026Signature=PQNMHdWZ-FbuDdUOiiLYZSj46SPiYQSQNFgNkqSkmaCwSvameIEpgXmEk2-a6tohaP5yA1NUjhiT3zAHBArXRCA2t-TXWD-lfe7HLxRPKClx4ARU-whOdLYWOx5PRaetizXJIBpEgxp3JVsAGcLEYPn60i0Ux6y2ujODJPA01Dyf4gc-clfvXnJVNPpmALKkkfCa0vrDnSFywwXpFqzxT6mq22K1HejfQ4ikUhkY-7EdO3WqXBN8i6ZjN7tt1gzlpWTDhGeWk31nd2NNsW1CVG~8KCaJgd8CVDaO6gB60Ry4KovaOCweBLp1bKnvwUbLScCmTB4bstLPd2C8sSiPHg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849710"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/65849710/Lymphatic_and_hematopoietic_cancers_among_benzene_exposed_workers"><img alt="Research paper thumbnail of Lymphatic and hematopoietic cancers among benzene-exposed workers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/65849710/Lymphatic_and_hematopoietic_cancers_among_benzene_exposed_workers">Lymphatic and hematopoietic cancers among benzene-exposed workers</a></div><div class="wp-workCard_item"><span>Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">High benzene exposure is related to acute nonlymphocytic leukemia. Recently, myelodysplastic synd...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">High benzene exposure is related to acute nonlymphocytic leukemia. Recently, myelodysplastic syndrome has been observed at low benzene exposure levels. We updated a mortality study of workers with benzene exposure examining acute nonlymphocytic leukemia and myelodysplastic syndrome. We calculated standardized mortality ratios with 95% confidence intervals and examined latency and trends for cumulative exposure levels. All leukemias (standardized mortality ratio = 1.21; 95% confidence interval = 0.74 to 1.97) and acute non-lymphocytic leukemia (standardized mortality ratio = 1.04; 95% confidence interval = 0.34 to 2.44) were at expected levels. We observed one death from myelodysplastic syndrome (standardized mortality ratio = 6.48; 95% confidence interval = 0.17 to 38.15). We observed no trend for cumulative exposure levels. Our results for all leukemias are consistent with a small increase in risk observed in the lower-exposed subgroups of the Pliofilm study; however, our results a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849710"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849710"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849710; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849710]").text(description); $(".js-view-count[data-work-id=65849710]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849710; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849710']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65849710]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849710,"title":"Lymphatic and hematopoietic cancers among benzene-exposed workers","internal_url":"https://www.academia.edu/65849710/Lymphatic_and_hematopoietic_cancers_among_benzene_exposed_workers","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849709"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/65849709/Incomplete_follow_up_in_the_National_Cancer_Institute_s_formaldehyde_worker_study_and_the_impact_on_subsequent_reanalyses_and_causal_evaluations"><img alt="Research paper thumbnail of Incomplete follow-up in the National Cancer Institute’s formaldehyde worker study and the impact on subsequent reanalyses and causal evaluations" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/65849709/Incomplete_follow_up_in_the_National_Cancer_Institute_s_formaldehyde_worker_study_and_the_impact_on_subsequent_reanalyses_and_causal_evaluations">Incomplete follow-up in the National Cancer Institute’s formaldehyde worker study and the impact on subsequent reanalyses and causal evaluations</a></div><div class="wp-workCard_item"><span>Regulatory Toxicology and Pharmacology</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Three of us (G.M., A.Y., and P.M.) performed reanalyses of the National Cancer Institute cohort s...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Three of us (G.M., A.Y., and P.M.) performed reanalyses of the National Cancer Institute cohort study on nasopharyngeal cancer (NPC) risk among formaldehyde exposed workers (Hauptmann et al., 2004). Both reanalyses (Marsh and Youk, 2005; Marsh et al., 2007) were published in this journal. However, the mortality follow-up performed by the NCI working group reported in two publications by Hauptmann et al. (2003, 2004) was later stated to be incomplete (Beane Freeman et al., 2009a,b). This incomplete follow-up may impact the validity of the results of our reanalyses. At this time, corrected estimates for solid cancer mortality risks including NPC as reported in Hauptmann et al. (2004) have not been provided as an erratum by the authors or reported anywhere else to our knowledge. We would like to inform readers about these issues and ask for a prompt corrigendum of the 2004 publication by the NCI working group since this study has played such a prominent role in causal evaluations.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849709"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849709"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849709; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849709]").text(description); $(".js-view-count[data-work-id=65849709]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849709; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849709']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65849709]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849709,"title":"Incomplete follow-up in the National Cancer Institute’s formaldehyde worker study and the impact on subsequent reanalyses and causal evaluations","internal_url":"https://www.academia.edu/65849709/Incomplete_follow_up_in_the_National_Cancer_Institute_s_formaldehyde_worker_study_and_the_impact_on_subsequent_reanalyses_and_causal_evaluations","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849708"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849708/Cancer_dose_response_assessment_for_acrylonitrile_based_upon_rodent_brain_tumor_incidence_Use_of_epidemiologic_mechanistic_and_pharmacokinetic_support_for_nonlinearity"><img alt="Research paper thumbnail of Cancer dose–response assessment for acrylonitrile based upon rodent brain tumor incidence: Use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity" class="work-thumbnail" src="https://attachments.academia-assets.com/77268379/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849708/Cancer_dose_response_assessment_for_acrylonitrile_based_upon_rodent_brain_tumor_incidence_Use_of_epidemiologic_mechanistic_and_pharmacokinetic_support_for_nonlinearity">Cancer dose–response assessment for acrylonitrile based upon rodent brain tumor incidence: Use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity</a></div><div class="wp-workCard_item"><span>Regulatory Toxicology and Pharmacology</span><span>, 2005</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A cancer dose-response assessment was conducted for acrylonitrile (AN) using updated information ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A cancer dose-response assessment was conducted for acrylonitrile (AN) using updated information on mechanism of action, epidemiology, toxicity, and pharmacokinetics. Although more than 10 chronic bioassays indicate that AN produces multiple tumors in rats and mice, a number of large, well-conducted epidemiology studies provide no evidence of a causal association between AN exposure and cancer mortality of any type. The epidemiological data include early industry exposures that are far higher than occur today and that approach or exceed levels found to be tumorigenic in animals. Despite the absence of positive Wndings in the epidemiology data, a dose-response assessment was conducted for AN based on brain tumors in rats. Mechanistic studies implicate the involvement of oxidative stress in rat brain due to a metabolite (2-cyanoethylene oxide or CEO, cyanide), but do not conclusively rule out a potential role for the direct genotoxicity of CEO. A PBPK model was used to predict internal doses (peak CEO in brain) for 12 data sets, which were pooled together to provide a consistent characterization of the dose-response relationship for brain tumor incidence in the rat. The internal dose corresponding to a 5% increase in extra risk (ED05 D 0.017 mg/L brain) and its lower conWdence limit (LED05 D 0.014 mg/L brain) was used as the point of departure. The weight-of-evidence supports the use of a nonlinear extrapolation for the cancer dose-response assessment. A quantitative comparison of the epidemiology exposure-response data (lung and brain cancer mortality) to the rat brain tumor data in terms of internal dose adds to the conWdence in the nonlinear extrapolation. Uncertainty factors of 200 and 220 (for the oral and inhalation routes, respectively) were applied to the LED05 to account for interspecies variation, intraspecies variation, and the severity of the response measure. Accordingly, oral doses below 0.009 mg/kg-day and air concentrations below 0.1 mg/m 3 are not expected to pose an appreciable risk to human populations exposed to AN.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="ee67781bdd325ed8605b30ba6d0f83af" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268379,"asset_id":65849708,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268379/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849708"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849708"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849708; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849708]").text(description); $(".js-view-count[data-work-id=65849708]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849708; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849708']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "ee67781bdd325ed8605b30ba6d0f83af" } } $('.js-work-strip[data-work-id=65849708]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849708,"title":"Cancer dose–response assessment for acrylonitrile based upon rodent brain tumor incidence: Use of epidemiologic, mechanistic, and pharmacokinetic support for nonlinearity","internal_url":"https://www.academia.edu/65849708/Cancer_dose_response_assessment_for_acrylonitrile_based_upon_rodent_brain_tumor_incidence_Use_of_epidemiologic_mechanistic_and_pharmacokinetic_support_for_nonlinearity","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[{"id":77268379,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77268379/thumbnails/1.jpg","file_name":"j.yrtph.2005.06.00720211224-24339-1adko01.pdf","download_url":"https://www.academia.edu/attachments/77268379/download_file","bulk_download_file_name":"Cancer_dose_response_assessment_for_acry.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77268379/j.yrtph.2005.06.00720211224-24339-1adko01-libre.pdf?1640352884=\u0026response-content-disposition=attachment%3B+filename%3DCancer_dose_response_assessment_for_acry.pdf\u0026Expires=1739852562\u0026Signature=aw6OetxE8iOVT1d8aOKaB0y8f67kfBsyP1ByiSsBQrQ8ZnT4D7vEplFKnsxi2BDzr08v2MpEaD5ovbgupTaaH5Zfe7ShAPZb~sEoXlSmWF5GIQgVOVgS-qlrV6ncJUevVdWqzT9sx7ce7mWKmnbyejtMvmyfLZVrVjjIxc-aA5UqQF0sk8fbCi2yBXJp9x5XjGCetOc~lJ2hwz3ACTMf6CIwQjOAxcY4gCIHf1Jf3UnYSUZrE~MCB7PQofgyQYDkYHADd9d75Nwiy8PHYDPq2Woj9yA9u5UPHrT5dztVQ5TnIbf2rz1RV1yDbyLtNU1f0e~rSQaYcER1Oykt1K5OoA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849706"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849706/Issues_of_methods_and_interpretation_in_the_National_Cancer_Institute_formaldehyde_cohort_study"><img alt="Research paper thumbnail of Issues of methods and interpretation in the National Cancer Institute formaldehyde cohort study" class="work-thumbnail" src="https://attachments.academia-assets.com/77268304/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849706/Issues_of_methods_and_interpretation_in_the_National_Cancer_Institute_formaldehyde_cohort_study">Issues of methods and interpretation in the National Cancer Institute formaldehyde cohort study</a></div><div class="wp-workCard_item"><span>Journal of Occupational Medicine and Toxicology</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In 2004, the International Agency for Research on Cancer (IARC) reclassified formaldehyde (FA) fr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In 2004, the International Agency for Research on Cancer (IARC) reclassified formaldehyde (FA) from a probable (Group 2A) to a known human carcinogen (Group 1) citing results for nasopharyngeal cancer (NPC) mortality from the follow-up through 1994 of the National Cancer Institute formaldehyde cohort study. To the contrary, in 2012, the Committee for Risk Assessment of the European Chemicals Agency disagreed with the proposal to classify FA as a known human carcinogen (Carc. 1A), proposing a lower but still protective category, namely as a substance which is presumed to have carcinogenic potential for humans (Carc. 1B). Thus, U.S. and European regulatory agencies currently disagree about the potential human carcinogenicity of FA. In 2013, the National Cancer Institute reported results from their follow-up through 2004 of the formaldehyde cohort and concluded that the results continue to suggest a link between FA exposure and NPC. We discuss in this commentary why we believe that this interpretation is neither consistent with the available data from the most recent update of the National Cancer Institute cohort study nor with other research findings from that cohort, other large cohort studies and the series of publications by some of the current authors, including an independent study of one of the National Cancer Institute's study plants. Another serious concern relates to the incorrectness of the data from the follow-up through 1994 of the National Cancer Institute study stemming from incomplete mortality ascertainment. While these data were corrected by the National Cancer Institute in subsequent supplemental publications, incorrect data from the original publications have been cited extensively in recent causal evaluations of FA, including IARC. We conclude that the NCI publications that contain incorrect data from the incomplete 1994 mortality follow-up should be retracted entirely or corrected via published errata in the corresponding journals, and efforts should be made to re-analyze data from the 2004 follow-up of the NCI cohort study.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d09530b722360596368a83bc6b74641e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268304,"asset_id":65849706,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268304/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849706"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849706"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849706; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849706]").text(description); $(".js-view-count[data-work-id=65849706]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849706; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849706']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d09530b722360596368a83bc6b74641e" } } $('.js-work-strip[data-work-id=65849706]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849706,"title":"Issues of methods and interpretation in the National Cancer Institute formaldehyde cohort study","internal_url":"https://www.academia.edu/65849706/Issues_of_methods_and_interpretation_in_the_National_Cancer_Institute_formaldehyde_cohort_study","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[{"id":77268304,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77268304/thumbnails/1.jpg","file_name":"1745-6673-9-22.pdf","download_url":"https://www.academia.edu/attachments/77268304/download_file","bulk_download_file_name":"Issues_of_methods_and_interpretation_in.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77268304/1745-6673-9-22-libre.pdf?1640352889=\u0026response-content-disposition=attachment%3B+filename%3DIssues_of_methods_and_interpretation_in.pdf\u0026Expires=1739852562\u0026Signature=TsxRB2-ALyODrf~gk~tk8DS-iamJ7wByfGPeOqr7bc~GW7fkkJmOmGFR7SKVtk~wyh-KB7lSYgCWZJdIpj43enDxZz-n6cQmTyKBpo24kJhSrmjeUGMEkU1~vLG6sLuotAnr5ReEr5PIIV3FfypNV38rOgBwQ7qJTtYqyK9XvZQ8cMTtIaTow7Rp4dSPjuP4zaJIRDAVdqUoX9rL5Slj9Ztt0NvMmIsI4rtQiedPurUULw5V7EJY-Ibi8oNAAK2M8BNCYp4cwscpawjmn3IrUZK5KRSG0HEGvOSHkTTT7oZETXOSsrjSIDRF-yfVayLsgAW~Im~b0V4Ek4LQG415ug__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849704"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849704/Cancer_risk_for_chemical_workers_exposed_to_2_3_7_8_tetrachlorodibenzo_p_dioxin"><img alt="Research paper thumbnail of Cancer risk for chemical workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin" class="work-thumbnail" src="https://attachments.academia-assets.com/77268302/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849704/Cancer_risk_for_chemical_workers_exposed_to_2_3_7_8_tetrachlorodibenzo_p_dioxin">Cancer risk for chemical workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin</a></div><div class="wp-workCard_item"><span>Occupational and Environmental Medicine</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aims: To describe the long term mortality experience of a cohort of 2187 male chemical production...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aims: To describe the long term mortality experience of a cohort of 2187 male chemical production workers previously exposed to substantial levels of dioxin. Methods: Vital status for a previously identified cohort was determined for an additional 10 years, to 1995. Dioxin exposures took place before 1983 and were sufficient to result in chloracne in 245 individuals. Mortality rates were compared with national figures and with a large pool of co-workers in unrelated production jobs. Results: All cancers combined (standardised mortality ratio (SMR) = 1.0, 95% CI 0.8 to 1.1) and lung cancer (SMR = 0.8, 95% CI 0.6 to 1.1) were at or below expected levels. Rates for soft tissue sarcoma (SMR = 2.4, 95% CI 0.3 to 8.6) and non-Hodgkin's lymphoma (SMR = 1.4, 95% CI 0.6 to 2.7) were greater than expected overall, but below expectation in the update period. No trend of increasing risk with increasing exposure was observed for these cancers. Workers who developed chloracne had very low all-cancer rates (SMR = 0.5, 95% CI 0.3 to 1.0), and lung cancer rates (SMR = 0.3, 95% CI 0.0 to 1.1). Conclusions: We found no coherent evidence of increased cancer risk from dioxin exposure in this cohort. Our study highlights the wide range of cancer rates and the lack of consistency across dioxin studies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="19583e1cc549c72b7a5d2957ff474c64" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268302,"asset_id":65849704,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268302/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849704"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849704"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849704; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849704]").text(description); $(".js-view-count[data-work-id=65849704]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849704; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849704']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "19583e1cc549c72b7a5d2957ff474c64" } } $('.js-work-strip[data-work-id=65849704]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849704,"title":"Cancer risk for chemical workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin","internal_url":"https://www.academia.edu/65849704/Cancer_risk_for_chemical_workers_exposed_to_2_3_7_8_tetrachlorodibenzo_p_dioxin","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[{"id":77268302,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77268302/thumbnails/1.jpg","file_name":"fda1abab26cd015a4cfc866d8b8b9006e91e.pdf","download_url":"https://www.academia.edu/attachments/77268302/download_file","bulk_download_file_name":"Cancer_risk_for_chemical_workers_exposed.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77268302/fda1abab26cd015a4cfc866d8b8b9006e91e-libre.pdf?1640352888=\u0026response-content-disposition=attachment%3B+filename%3DCancer_risk_for_chemical_workers_exposed.pdf\u0026Expires=1739852562\u0026Signature=GTU3g3qQbEsX0KPw8CpOIPVtH8WFHEw2JYEQueTw-L2LkCzU3RGXzknHrTwztWsqqCt0JxTdQjbFLFtRunVdZY0tLZbfgdTEj26cRW-MHyURZLMnRKPAX8fAbVyR6vcGB23ixRXZcua2kpMFF-95SPSTmn2Y6iu-EqtVqhH9HtiNIbCV2~PfeqKtvfb5dAF6p3QJzI~w9VXQeSbIlAhw7mIIJ6bgPC0qPjAPgZo0eLMWJp49EJB9KKq5xiQG-LUN3JAGX5pP~PhXp1mhXZmcVZsE5bRY6ckPRuHRRJ4CSard8Y-43wpqBPYj~1LuGMc9sS6LYlEec989F1ZibuF7IA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849702"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849702/Reevaluation_of_lung_cancer_risk_in_the_acrylonitrile_cohort_study_of_the_National_Cancer_Institute_and_the_National_Institute_for_Occupational_Safety_and_Health"><img alt="Research paper thumbnail of Reevaluation of lung cancer risk in the acrylonitrile cohort study of the National Cancer Institute and the National Institute for Occupational Safety and Health" class="work-thumbnail" src="https://attachments.academia-assets.com/77268471/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849702/Reevaluation_of_lung_cancer_risk_in_the_acrylonitrile_cohort_study_of_the_National_Cancer_Institute_and_the_National_Institute_for_Occupational_Safety_and_Health">Reevaluation of lung cancer risk in the acrylonitrile cohort study of the National Cancer Institute and the National Institute for Occupational Safety and Health</a></div><div class="wp-workCard_item"><span>Scandinavian Journal of Work, Environment & Health</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Objectives The present study provides additional analyses of data obtained earlier on lung cancer...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Objectives The present study provides additional analyses of data obtained earlier on lung cancer risk among workers with acrylonitrile exposure. Methods The original authors provided the data. For total mortality and the cancer sites of a priori interest (lung, stomach, brain, breast, prostate, and the lymphatic and hematopoietic systems), standardized mortality ratios (SMR) and 95% confidence intervals (95% CI) were computed, the total United States and surrounding counties being used as standard populations. Regional rate-based SMR values were also computed between lung cancer and cumulative acrylonitrile exposure. Results Except for lung cancer, the external comparisons corroborated the earlier internal comparisons (no increased cancer mortality risk). For lung cancer, the external comparisons revealed death deficits for the unexposed workers (SMR 0.68, 95% CI 0.5-0.9) and all categories of acrylonitrile-exposed workers. The SMR obtained using external rates and the most exposed group (SMR 0.92, 95% CI 0.6-1.4) differed from the corresponding relative risk (RR) of the internal rates (RR 1.5, 95% CI 0.9-2.4). Conclusions The analysis of the present study provides little evidence that acrylonitrile exposure increases the mortality risk of cancers of a priori interest, including lung cancer. The lung cancer findings of the external comparison differed from the earlier findings of the internal comparisons. Selection bias (as the healthy worker effect) was probably not responsible. Additional follow-up and analyses, especially of the unexposed workers with low lung cancer rates, may help elucidate the internal and external comparison differences. Results from both comparisons should be presented when the relative risks differ markedly, as both have advantages and disadvantages.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1c8abd555ccc98795ff097308b066a4c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268471,"asset_id":65849702,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268471/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849702"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849702"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849702; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849702]").text(description); $(".js-view-count[data-work-id=65849702]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849702; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849702']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1c8abd555ccc98795ff097308b066a4c" } } $('.js-work-strip[data-work-id=65849702]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849702,"title":"Reevaluation of lung cancer risk in the acrylonitrile cohort study of the National Cancer Institute and the National Institute for Occupational Safety and Health","internal_url":"https://www.academia.edu/65849702/Reevaluation_of_lung_cancer_risk_in_the_acrylonitrile_cohort_study_of_the_National_Cancer_Institute_and_the_National_Institute_for_Occupational_Safety_and_Health","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[{"id":77268471,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77268471/thumbnails/1.jpg","file_name":"download.pdf","download_url":"https://www.academia.edu/attachments/77268471/download_file","bulk_download_file_name":"Reevaluation_of_lung_cancer_risk_in_the.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77268471/download-libre.pdf?1640352912=\u0026response-content-disposition=attachment%3B+filename%3DReevaluation_of_lung_cancer_risk_in_the.pdf\u0026Expires=1739852562\u0026Signature=cTQEnb~sbLVpqnakI-SADRXzAgVnrO-ubettDYyu5ESBr8ataoE4BT4T2E9z5aBBiLGKVQlda5GzWgD1iwGGfQej5mNOAWwrzxNYnRIxEHwz6~l1yQBV3U28Drl7uo4U1Pr~KJZR9KyTBYVei6eGqXoW2VlJhun3T6FseYOUdOTQ2syIkdgUdrgCQd-PezU2KtwsSwrYKpd3L8iyuR4N4Wto3kO3vPWDnrb4vvX2qqIUh5OqzAX~4Nyrb~BUJhqYcU7xH004SSj6QzjgItXlMq5Y1pwBQ3xlJdr~~uzMr~sVyTpBvO6y1Ab6AFIF~8UfQuCL2NqdGZ4IyOu1k4nvsw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849700"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/65849700/A_Risk_Assessment_for_Occupational_Acrylonitrile_Exposure_Using_Epidemiology_Data"><img alt="Research paper thumbnail of A Risk Assessment for Occupational Acrylonitrile Exposure Using Epidemiology Data" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/65849700/A_Risk_Assessment_for_Occupational_Acrylonitrile_Exposure_Using_Epidemiology_Data">A Risk Assessment for Occupational Acrylonitrile Exposure Using Epidemiology Data</a></div><div class="wp-workCard_item"><span>Risk Analysis</span><span>, 2004</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The extensive data from the Blair et al.((1)) epidemiology study of occupational acrylonitrile ex...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The extensive data from the Blair et al.((1)) epidemiology study of occupational acrylonitrile exposure among 25460 workers in eight plants in the United States provide an excellent opportunity to update quantitative risk assessments for this widely used commodity chemical. We employ the semiparametric Cox relative risk (RR) regression model with a cumulative exposure metric to model cause-specific mortality from lung cancer and all other causes. The separately estimated cause-specific cumulative hazards are then combined to provide an overall estimate of age-specific mortality risk. Age-specific estimates of the additional risk of lung cancer mortality associated with several plausible occupational exposure scenarios are obtained. For age 70, these estimates are all markedly lower than those generated with the cancer potency estimate provided in the USEPA acrylonitrile risk assessment.((2)) This result is consistent with the failure of recent occupational studies to confirm elevated lung cancer mortality among acrylonitrile-exposed workers as was originally reported by O&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;Berg,((3)) and it calls attention to the importance of using high-quality epidemiology data in the risk assessment process.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849700"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849700"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849700; 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This paper responds to that call by demonstrating a distributional approach that draws upon human data to derive potency estimates and to identify and quantify important sources of uncertainty. The approach is rooted in the science of decision analysis and employs an influence diagram, a decision tree, probabilistic weights, and a distribution of point estimates of carcinogenic potency. Its results estimate the likelihood of different carcinogenic risks (potencies) for a chemical under a specific scenario. For this exercise, human data on formaldehyde were employed to demonstrate the approach. Sensitivity analyses were performed to determine the relative impact of specific levels and alternatives on the potency distribution. The resulting potency estimates are compared with the results of an exercise using animal data on formaldehyde. The paper demonstrates that distributional risk assessment is readily adapted to situations in which epidemiologic data serve as the basis for potency estimates. Strengths and weaknesses of the distributional approach are discussed. Areas for further application and research are recommended.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cdc7a10bf4ea1fe5dfd576a416060773" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268312,"asset_id":65849698,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268312/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849698"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849698"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849698; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cdc7a10bf4ea1fe5dfd576a416060773" } } $('.js-work-strip[data-work-id=65849698]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849698,"title":"Quantifying Uncertainty in a Risk Assessment Using Human Data","internal_url":"https://www.academia.edu/65849698/Quantifying_Uncertainty_in_a_Risk_Assessment_Using_Human_Data","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[{"id":77268312,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77268312/thumbnails/1.jpg","file_name":"a_3A100702651019820211224-24336-u427w3.pdf","download_url":"https://www.academia.edu/attachments/77268312/download_file","bulk_download_file_name":"Quantifying_Uncertainty_in_a_Risk_Assess.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77268312/a_3A100702651019820211224-24336-u427w3-libre.pdf?1640352887=\u0026response-content-disposition=attachment%3B+filename%3DQuantifying_Uncertainty_in_a_Risk_Assess.pdf\u0026Expires=1739852562\u0026Signature=YoINgj4TLQPtRtNvSsNgX2xbVzTgGlDTV1O6-3CD7TJ5yw1XnD23SnLOx8CnM4Hm3eR4JK5vnRKI3mc4yxPFSFVhgM4AIgRmy-tXAffY-uFY~jyTYFizSg3W7yJD4hfV74OVHIs3Pw-HR2KoJK8WXcDRRyZ4b3FFGdqZNw29Rt33N-sEx78O2saQQAYsciKf2myKlAkTfmCkMQo3s4kFt9v8C~Cvmd-ay4N0If68olmuSf61GyiCAv-05KvOC2PERrKr~wZro0he7nOYjv9pIiaTKTMfU47Gb8JD1ilMjXeo98l2606c7PmA-8AesSl~ftPBRvg0MH04QaMsk5m3EQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849695"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849695/Evaluating_emerging_issues_in_epidemiology"><img alt="Research paper thumbnail of Evaluating emerging issues in epidemiology" class="work-thumbnail" src="https://attachments.academia-assets.com/77268378/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849695/Evaluating_emerging_issues_in_epidemiology">Evaluating emerging issues in epidemiology</a></div><div class="wp-workCard_item"><span>Regulatory Toxicology and Pharmacology</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Industry and government institutions need a credible approach for evaluating and responding to em...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Industry and government institutions need a credible approach for evaluating and responding to emerging public health issues. Representatives of industry, government, and academia met under the auspices of the International Life Sciences Institute's Health and Environmental Sciences Institute (HESI) to develop successful strategies for dealing with emerging issues based on historical case studies. The case studies chosen for evaluation were (1) tampon use and toxic shock syndrome; (2) hazardous waste and childhood cancer risk in Toms River, New Jersey; (3) fenfluramine and phentermine use and valvular heart disease; (4) silicone breast implants and cancer and auto-immune disease; and (5) progestational drugs and birth defects. We identified eight lessons from these case studies. Foremost, we recommend that public and private institutions not defer action until an issue is scientifically resolved and stress that cooperation among issue stakeholders is critical for effective issue resolution. We suggest establishing a research program as an effective way to assure that good science is included in resolution of the issue. We further recommend frequent and timely communication with all stakeholders, and the development of research approaches to fill gaps when the scientific data on an issue are limited.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="57c12c4a01bf8bea532c38376a841e6b" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268378,"asset_id":65849695,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268378/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849695"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849695"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849695; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849693"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/65849693/The_healthy_worker_effect_in_US_chemical_industry_workers"><img alt="Research paper thumbnail of The healthy worker effect in US chemical industry workers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/65849693/The_healthy_worker_effect_in_US_chemical_industry_workers">The healthy worker effect in US chemical industry workers</a></div><div class="wp-workCard_item"><span>Occupational Medicine</span><span>, 2011</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Occupational studies typically observe a 20% deficit in overall mortality, broadly characterized ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Occupational studies typically observe a 20% deficit in overall mortality, broadly characterized as the healthy worker effect (HWE). Components of the HWE may be addressed by various analytical approaches. To explore the HWE in a modern industrial cohort. Standardized mortality ratios (SMRs) were calculated for 114,683 US chemical industry employees, who worked at least 3 days between 1960 and 2005. SMRs were 79 (95% confidence interval 78-80) for all causes, 81 (95% confidence interval 79-82) for heart disease, 70 (95% confidence interval 67-73) for non-malignant respiratory disease, 83 (95% confidence interval 81-85) for smoking-related cancers (buccal, cervix, oesophagus, stomach, pancreas, lung, larynx, bladder and kidney) combined and 97 (95% confidence interval 95-100) for other cancers. The low SMRs observed in this study are likely due to differential smoking between the cohort and the background population. Future considerations to control for the HWE should take this into account.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849693"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849693"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849693; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849693]").text(description); $(".js-view-count[data-work-id=65849693]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849693; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849693']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=65849693]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849693,"title":"The healthy worker effect in US chemical industry workers","internal_url":"https://www.academia.edu/65849693/The_healthy_worker_effect_in_US_chemical_industry_workers","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849691"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/65849691/Slips_trips_and_falls_at_a_chemical_manufacturing_company"><img alt="Research paper thumbnail of Slips, trips and falls at a chemical manufacturing company" class="work-thumbnail" src="https://attachments.academia-assets.com/77268299/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/65849691/Slips_trips_and_falls_at_a_chemical_manufacturing_company">Slips, trips and falls at a chemical manufacturing company</a></div><div class="wp-workCard_item"><span>Occupational Medicine</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background Slips, trips and falls (STF) are a major cause of workplace injury. Aims To examine ri...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background Slips, trips and falls (STF) are a major cause of workplace injury. Aims To examine risk factors for STF at a large US chemical manufacturing company. Methods We conducted a case-control study of occupational STF. Cases were identified from company injury records between 1 April 2009 and 1 May 2011. Four controls per case were randomly selected from all active company workers employed during the same time. Data were collected through a questionnaire and from company medical examinations. Logistic regression was used to calculate odds ratio (OR) and 95% confidence intervals (95% CI) for personal, environmental and health-related risk factors for STF. Results There were 74 cases and 309 controls. The response rate was 65% for the cases and 68% for the controls. Most STF were unrelated to production activities. When examining all factors in a logistic regression model, increased OR were observed for increased body mass index (OR = 1.44, 95% CI: 1.03-2.02), having arthritis (OR = 2.11, 95% CI: 1.01-4.37), lack of exercise (OR = 2.25, 95% CI: 1.01-5.05), carrying materials (OR = 3.01, 95% CI: 1.41-6.43) and being female (OR = 2.46, 95% CI: 1.17-5.19). Reduced risk of STF was observed for never having smoked (OR = 0.48, 95% CI: 0.24-0.95), long service (OR = 0.53, 95% CI: 0.34-0.81) and persons working over 8 h a day (OR = 0.42, 95% CI: 0.20-0.88). Conclusions Risk factors for STF in a large US chemical company are similar to those reported from other workplaces, but we found that staying fit and healthy is important for reducing risk.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2e74d7c938c7c56bc0a21248643db937" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":77268299,"asset_id":65849691,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/77268299/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849691"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849691"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849691; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849691]").text(description); $(".js-view-count[data-work-id=65849691]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 65849691; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='65849691']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2e74d7c938c7c56bc0a21248643db937" } } $('.js-work-strip[data-work-id=65849691]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":65849691,"title":"Slips, trips and falls at a chemical manufacturing company","internal_url":"https://www.academia.edu/65849691/Slips_trips_and_falls_at_a_chemical_manufacturing_company","owner_id":194344425,"coauthors_can_edit":true,"owner":{"id":194344425,"first_name":"Jim","middle_initials":null,"last_name":"Collins","page_name":"JimCollins37","domain_name":"independent","created_at":"2021-05-25T06:47:49.322-07:00","display_name":"Jim Collins","url":"https://independent.academia.edu/JimCollins37"},"attachments":[{"id":77268299,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/77268299/thumbnails/1.jpg","file_name":"5d125ed7dcdce4cf2f1a9a3bdcf08dcc92c6.pdf","download_url":"https://www.academia.edu/attachments/77268299/download_file","bulk_download_file_name":"Slips_trips_and_falls_at_a_chemical_manu.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/77268299/5d125ed7dcdce4cf2f1a9a3bdcf08dcc92c6-libre.pdf?1640352888=\u0026response-content-disposition=attachment%3B+filename%3DSlips_trips_and_falls_at_a_chemical_manu.pdf\u0026Expires=1739852562\u0026Signature=UOfQeQHeJvgE9YO3lLBQzVMopgUGceXbbggQ9Tb01sG4qMrdb8dAQ3mIYhCdM83DnGGHkkhlW~GQjKKvdLR2wxi~Vqs-cJIJg0pbM13W1zSdXw~Z1VhdEUmJp8QT94JyeN8X96c6BFmb-PDd5KzB7YODKGAQUX~aAtDuGVzQE9OHwfE04sE5ICV9i7VzdcPLlz9V2Vqo4lLvT30yVWt6YkevnWgWDRve0egf6K6PvZBCOIYV-hyjwMFFGAG0BNezUuURo7U4EMRHKyxJmrxZdU~AgWuTi0s2Wcpgw3wwF0FZa5~rW2Me1gsyxTma5HPCwXTacUvqJyoAA6pRXGxAjA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="65849689"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/65849689/Mortality_study_update_of_acrylamide_workers"><img alt="Research paper thumbnail of Mortality study update of acrylamide workers" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/65849689/Mortality_study_update_of_acrylamide_workers">Mortality study update of acrylamide workers</a></div><div class="wp-workCard_item"><span>Occupational and Environmental Medicine</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The authors examined the long-term health effects of occupational exposure to acrylamide among pr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The authors examined the long-term health effects of occupational exposure to acrylamide among production and polymerisation workers. An earlier study of 371 acrylamide workers was expanded to include employees hired since 1979. In this updated study, 696 acrylamide workers were followed from 1955 through 2001 to ascertain vital status and cause of death. Exposure to acrylamide was retrospectively assessed based on personal samples from the 1970s onwards and area samples over the whole study period. Fewer of the acrylamide workers died (n = 141) compared to an expected number of 172.1 (SMR 81.9, 95% CI 69.0 to 96.6). No cause-specific SMR for any of the investigated types of cancer was exposure related. The authors did, however, find more pancreatic cancer deaths than expected (SMR 222.2, 95% CI 72.1 to 518.5). With respect to non-malignant disease, more diabetes deaths were observed than expected (SMR 288.7, 95% CI 138.4 to 531.0). To assess the influence of regional factors, the analysis was repeated with an internal reference population. The elevated SMR for diabetes persisted. This study provides little evidence for a cancer risk from occupational exposure to acrylamide at production facilities. However, the increased rates of pancreatic cancer in this study and another larger study of acrylamide production workers indicate that caution is needed to rule out a cancer risk. The authors believe that the excess of diabetes mortality in this study is most likely not related to acrylamide exposure, because a larger study of acrylamide workers reported a deficit in this cause of death. The authors conclude that the increased SMR for diabetes mortality is probably not related to regional influences.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="65849689"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="65849689"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 65849689; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=65849689]").text(description); 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