CINXE.COM

<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="120"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "publications.waset.org",cType: 'non-interactive',cRay: '9134a83b1c013df9',cH: '5c1txICQCsihNXGWjndkxr1JUz3rXp6xFa.xWyPZbSs-1739783561-1.2.1.1-ntUP_TkvHqX0O91TAbdbkLQQdJpI_ksPWzq8m4WI.KFZfMhPEnMxZ8VJrLXF_JA_',cUPMDTk: "\/abstracts\/search?q=fillers&__cf_chl_tk=.8aT4CAG3TRY7utHF1vVGvrVoPVReQ9yt9HAeQ14x7o-1739783561-1.0.1.1-2_FFk_jbt9Hyl_357W9UrgcZS9KM2DaF.JRvqi1nS.U",cFPWv: 'b',cITimeS: '1739783561',cTTimeMs: '1000',cMTimeMs: '120000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/abstracts\/search?q=fillers&__cf_chl_f_tk=.8aT4CAG3TRY7utHF1vVGvrVoPVReQ9yt9HAeQ14x7o-1739783561-1.0.1.1-2_FFk_jbt9Hyl_357W9UrgcZS9KM2DaF.JRvqi1nS.U",md: "gwfuLiHcBwb.sMTeYgFVXYMHVpxid58BXOMmLEArFSI-1739783561-1.2.1.1-XhBXqNi_pLOTDDjiF2_Ur5Vn0FCkWF5m1yzJ4VUJSDVO_sGlfMf9EPJQL_42rJzurda7PXE8ddSs_kkdvEK0kyu2xt1npAOILXgwYq6WSWW_CK8qM1WZh.eWEJPUk77jTToY4L32pGd88I02iy0AzhqsybwZjQleLe._p78PX3rpsSdzSdoAW.4Lm78q4EQGq1NZYsUh2Z5fMQDwNqVvII5NFTDOPKFfoIN8XJbuP_xEXJ9FLLMECvEB7ZMq7nk5tCKHg9CQ9EF2qW7vW1.2_PSboJdhH0e7xRMcUpUSPUKLT9Sjlc1kRgjWWLOWRRVzdmykObpIaiIKjWYb4BEtgYFRU3EPhDCnBeNygMEisSrno.nwytz7D1g9yN83OAy61qIEgwk5A0tw14VaaWWEUx5T.mV0dLQ1Odoz0rcLa10xZPrsrV6uPtXNvE6HvIjpIyrfM.kYUyjJjMPA1o8GVRu5e3CsgxNl9voX5NRdmRRl.xdkV_.ZDjgdmfP1wcbFCBWhq6G8fQayKGP4FsygDbvQ1I5_yqhSgyJErlfr.OCbtokKObd1g84joBMXu2aFBds2Ool7ZjTmIQUSgZHuBk4W2lvXbTJnBqWsjnXRT4ehybkcOYK45r_JtilwvbguctKqR874GBl5B2YEInG9u3qHjwUDjn6wWmkrSwy5l.Pq159mMUDCTEGJG70LfgqCLo0vvPJ58f1Eff9uXaEvcfTt9o6v3H5N7oJbtnxGfTYkM1M723Ua4XOfNN_MBDQBproNldNeddIa5kBkpshDLR2JzluEg03DJWGvyZqLxi4zSA3aBRX2plV2lR3cQ.rE7fcmsQQV.hARk1PsOg4lXcPLFGpf_zOM1MDFNO8YB1HwHPB2uXXcgcdGCuquJWnXy1wiAriVB3UARRhaXdH0mwq.80ZnBzx0hjTe7QhIf8vripFHpkjVehu2oakQ0unBPzTMURsGEscMecfLExqREGAY0Ms7FuyIVx1XBRTZkp2ec0rCFESFvxfHUTLOEQyDoJaBRMdPlutZse8n_vmsEFZnsS9feqIp6Rk0jUe9J6RgHlvbI2a.95DuErTWP5aGbTMa4ON537gi.sW.DMkLRav21Zqcu4MDTAu4DrdUlpZabj5YlI5oY4xrjIorb616rw4ORvEI2nspC2HrHm90qBEVVP_oOAzHN3.aXh2Doic1cEks5afsrpgZfPA9dZFOza36h8QeJWyKRL7C74g3NyGkb7SveD7tMZ8QEy_wWlnN6e62RzHePjiJyXN1IZ9k_fshJzmhCNHUB8vmFW_nh8nH9iuVc3XPfYatKrnuUem_C2WnbaW2w_XIZTB47UnEOEo_sCSgJQetdN8FWX7LhmIsMUtwNLWC_WtUdbUxBz7i97SnUDg2wpHXBelOD1GDx_ejmy2yn6K_FhLKwn_OZsaVmZCjg2RlwxnKW16FBSRuHWh4itXq7fWxmeg6JpwdGninFMTKU.exGaCHry3CR65pg2lI_KaNwS1OO1bahLGzyf0ZYHVny03NJO8xkhk6msWjB5hdbKvBwp0Q_TEMCa5UyYK1RwnbQ5BMUysQj79DSJmu62c6wRJqEkm_dFbJ1RfhWR9IqpFpK5xPLYWMRsqEDCvS8Fx6N2Z9eUFjVY.KJ8Sg.E3s5lBzrEEJNmsKu0.Cxk9VCR84HD1CbLaX_IN63D1IheSeu6E6.KNA41EnOM0dKtXBHNSBezF0LOHWjvC21drpyoCyg0dX0THaetGfiqUlKhcFxWd.IXXCbz6PNy49U5vh1MYjoAu10yYglo240rYAWb8erLf5rQhXXQLKH.Twdn4i7HcoBXKYLov9wcmHSMQWjWwJ1Xg_3.5aA9kJ7fHdFqzZ9Mm8BjBpsvOQKC7VrqBThovCK5A2fElCL36r73tU36HElqQJrRyT_LnqnHgZiljQvrlJj_hC2g",mdrd: "wkXQOLCCxzh3608BwRBtr6_olN8gkg.y5HyfYLdJoeE-1739783561-1.2.1.1-nB3agpFCDNogop9tsJHe_9D1duhVTi9g0Z9uHK3lFpvUh4dtkyJDEHyaoJet7mXi..3mf9x49KUjIjZvSQIQT3PBvB4VFmbdMCwn5710gsMKgzKq8UiZAn0PHZNVNqdBq1EcBGimOEY.O5KO8iTRA0Jmed2x2vJm36oPVCPa1FYK8pPEj5rpaM55sJQ.Fq950EJ5lgF4DqxHVy_WYC4KIRIbZiTT3FVv1q8BwsR2lcAMnMIj4HIYXivDQEeX8.8S01w4m.BtHCd3.ROt50G42dnMY8dX6ocotWpe1JpwjnD5NuUJyJwYuPPZfH3Ghpj.RxMfLA0y_r5lhydQf57mYH6VI2uFCGL_yy0aU.VlR34mra3.CY0A2tyzAYacyLIY099BIdxbNomSDkGA8WWNi_pLY9SkQXJ2dM7hYOGIAlyQnxaw4Lh8kNIdf8X7BStIlt6BzeQFM559VQhwWxtbzNfROs225y.CQqLynMrQJ.WBJLUikY7fr0qTZj728MHriwRzr8A220_vcI491iyxEZE0HrFAU9fzMCygJFb8YYiK3sF6nymBVD3pp4rDqKr0LC72lDeZ6R4ZpFRop9J37fJU_vAlj7uQQXGJvreRZDY_ZlqTFk_6QDs5.MVPObvxfVmCrsklVwY1IlKHOSP7cWDUWtMr9vZH7gA5rxI_cDzkK5n.s8OMSX8oUlj9QJdtZFI0YAvS7gd2XkVVO2pO96Tr8MB6CzFqZHbzOpKpBL89.msT.1egvzTfdNTVyY.RxRhD6dR9EmLUN_a75JyjUs2FHrj9L6uZkNVypKTTglayMA8AVdDicl64SxuEZhQi.Vyau3s4U2J1nQxKtS9leLsCjRKSyLBElhC61PRPUPtcE9xCZdu2oHDr03kGYwQxKs7M8mc9Z118wvvsqigwU9stGqn09fchRhtrjkJKnOKMPYT7_O4p0u0w9Mww8p_zBtTl9TkBBWAWkFYGmfG7pG3GJdsT0oFNsIeZDwXggnlmt79.ntPYPtMTED.nddgwTd_h9DmFKbIWjeN72NA_moQJ5TxRVsIjNJz0GUvD5i35R27v6RNhOZHr5mmX.BlrjGrLCGM2KsqHs.WGPeGOe2vZEAEHHUrMKsS3y_hOkBQnN_AYtK2Si_uLMzLepYP2uw4pObZU__WDD0JcMN.lawkI1L.alpWoMzZ21JW3dp356gbGrIp_GUJMNve3iTTdGqAz8iXgHIlY_WCr93a.qBD43kpcQDAWJ1LxwOJEmcBX1QofazceqoZ4MtazGTdo9p36TC4r7RTYh5kygTeNEhjSGzL1iNp4VSrNdiQKgUjIpbzjTU6BcQs9AGSJf5NO3y2SqQjExJviv__.b5ZWfAtv9SEUrsyzu25PG7tx1WryImdWVAURuLIXPtkpIJYPs7_15lW4iulJBeWa4xO2l9grNXXqrDod4__kKrEW1C.T2.SzuvNl0JQnfCuOiQ3i56eYWIi4kfaT1RkX2SOoveY5VAPzFdyKLqm0SZ5Dlx_NzZ43h178DULbjKMw0FglTmViP6W0Subl8GhBAF_9gVh1VciWkDxx9cvm6QTmmqjuY84uMJ1uMJKc3XPC5rYcX0n0XL.ZQUCnb.68pdhW.F49dZVfiZ2VLLfnKszqGyz8jgqfxgHEJn6DQWlhRKOZVBx9uUdAUjmUvxVB7hS41T17.64JIHq_ckG928w_VJS2np1JfrlfOKaf_U5J9yAiJb4bKCpEzz4BrcnCQAZeb0Ba6zlPoD3rMwagjmeklfr4cuwWxUozPANTTRGghufXsgISApCz5LYWENWocjG2U0NIrhPDEIr_Bc1oCj7kNSXKY_XCx4g_moIoFODgp9zH7I3BTZzLAqgqbgoTHsPNdEWKvY61TfJyjmPBx5nKHQrG8LT..aORLDk9_ltC2iaP1V9jmsiYzK.BKcCpV0VETJIHpi.GNq2oKfcjmSLLwt_N.pwRupqMOejX1RanZ5XIiZ5ISVVDPQZB2hVXyhqpFQ"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=9134a83b1c013df9';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/abstracts\/search?q=fillers&__cf_chl_rt_tk=.8aT4CAG3TRY7utHF1vVGvrVoPVReQ9yt9HAeQ14x7o-1739783561-1.0.1.1-2_FFk_jbt9Hyl_357W9UrgcZS9KM2DaF.JRvqi1nS.U" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>