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data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">27</p></div></a><div class="js-mentions-count-container" style="display: none;"><a href="/LIacoviello/mentions"><div class="stat-container"><p class="label">Mentions</p><p class="data"></p></div></a></div><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="suggested-academics-container"><div class="suggested-academics--header"><p class="ds2-5-body-md-bold">Related Authors</p></div><ul class="suggested-user-card-list"><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://saic.academia.edu/JElkins"><img class="profile-avatar u-positionAbsolute" alt="James Elkins" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/15483/5205/5067/s200_james.elkins.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://saic.academia.edu/JElkins">James Elkins</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">School of the Art Institute of Chicago</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://sohag-univ.academia.edu/MoustafaMoharam"><img class="profile-avatar u-positionAbsolute" alt="Prof. Dr. Moustafa Moharam" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/46807/14659/21146422/s200_dr._moustafa.moharam.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://sohag-univ.academia.edu/MoustafaMoharam">Prof. Dr. Moustafa Moharam</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Sohag University</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://ubc.academia.edu/EKim"><img class="profile-avatar u-positionAbsolute" alt="Eric S . 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Kim (UBC)</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of British Columbia</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://wisc.academia.edu/EveEmshwiller"><img class="profile-avatar u-positionAbsolute" alt="Eve Emshwiller" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/77751/21575/19981/s200_eve.emshwiller.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://wisc.academia.edu/EveEmshwiller">Eve Emshwiller</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of Wisconsin-Madison</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://minufiya.academia.edu/drmahmoudlotfy"><img class="profile-avatar u-positionAbsolute" alt="Dr.Mahmoud Lotfy" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/105137/28932/26626/s200_dr.mahmoud.lotfy.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://minufiya.academia.edu/drmahmoudlotfy">Dr.Mahmoud Lotfy</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Minufiya University</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://sheffield.academia.edu/JonSayers"><img class="profile-avatar u-positionAbsolute" alt="Jon R Sayers" border="0" onerror="if (this.src != 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src="https://0.academia-photos.com/166004/402815/107544678/s200_tarek.kapiel.png" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://cairo.academia.edu/TarekKapiel">Tarek Kapiel</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Cairo University</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://mq.academia.edu/JohnSutton"><img class="profile-avatar u-positionAbsolute" alt="John Sutton" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/176044/43811/40295/s200_john.sutton.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://mq.academia.edu/JohnSutton">John Sutton</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Macquarie University</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://herts.academia.edu/KeithLaws"><img class="profile-avatar u-positionAbsolute" alt="Keith Laws" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/237753/52050/57634/s200_keith.laws.237753" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://herts.academia.edu/KeithLaws">Keith Laws</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">University of Hertfordshire</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://milliyasrcollege.academia.edu/Drasefiqbalmuhammed"><img class="profile-avatar u-positionAbsolute" alt="Dr. asef iqbal muhammed" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/882276/320523/861455/s200_dr._asef_iqbal.muhammed.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://milliyasrcollege.academia.edu/Drasefiqbalmuhammed">Dr. asef iqbal muhammed</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Milliya Arts, Science and Management Science College, Beed</p></div></div></ul></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a 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js-UserInfo-social"><li class="profile-profiles js-social-profiles-container"><i class="fa fa-spin fa-spinner"></i></li></ul></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Licia Iacoviello</h3></div><div class="js-work-strip profile--work_container" data-work-id="19608786"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608786/Genetic_and_environmental_influences_on_body_mass_index_in_European_children"><img alt="Research paper thumbnail of Genetic and environmental influences on body mass index in European children" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608786/Genetic_and_environmental_influences_on_body_mass_index_in_European_children">Genetic and environmental influences on body mass index in European children</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span 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$('.js-work-strip[data-work-id=19608786]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608786,"title":"Genetic and environmental influences on body mass index in European children","internal_url":"https://www.academia.edu/19608786/Genetic_and_environmental_influences_on_body_mass_index_in_European_children","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608785"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608785/Metabolic_syndrome_and_breast_cancer_risk_a_case_cohort_study_nested_in_a_multicentre_italian_cohort"><img alt="Research paper thumbnail of Metabolic syndrome and breast cancer risk: a case-cohort study nested in a multicentre italian cohort" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608785/Metabolic_syndrome_and_breast_cancer_risk_a_case_cohort_study_nested_in_a_multicentre_italian_cohort">Metabolic syndrome and breast cancer risk: a case-cohort study nested in a multicentre italian cohort</a></div><div class="wp-workCard_item"><span>PloS one</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Metabolic syndrome (defined as at least three among abdominal obesity, high blood triglycerides, ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Metabolic syndrome (defined as at least three among abdominal obesity, high blood triglycerides, low high-density lipoprotein cholesterol, high blood glucose, and high blood pressure) is emerging as a risk factor for breast cancer; however few studies - most confined to postmenopausal women - have investigated associations between breast cancer risk and metabolic syndrome. The purpose of this study was to examine the association between metabolic syndrome and its components, and risk of breast cancer in postmenopausal and premenopausal women. We performed a case-cohort study on 22,494 women recruited in 1993-1998 to four Italian centres (Turin, Varese, Naples, Ragusa) of the European Prospective Investigation into Cancer and Nutrition (EPIC) and followed-up for up to 15 years. A random subcohort of 565 women was obtained and 593 breast cancer cases were diagnosed. Hazard ratios (HR) with 95% confidence intervals (CI), adjusted for potential confounders, were estimated by Prentice-we...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608785"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608785"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608785; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608785]").text(description); $(".js-view-count[data-work-id=19608785]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608785; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608785']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608785]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608785,"title":"Metabolic syndrome and breast cancer risk: a case-cohort study nested in a multicentre italian cohort","internal_url":"https://www.academia.edu/19608785/Metabolic_syndrome_and_breast_cancer_risk_a_case_cohort_study_nested_in_a_multicentre_italian_cohort","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608784"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608784/Espresso_Coffee_Consumption_and_Risk_of_Coronary_Heart_Disease_in_a_Large_Italian_Cohort"><img alt="Research paper thumbnail of Espresso Coffee Consumption and Risk of Coronary Heart Disease in a Large Italian Cohort" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608784/Espresso_Coffee_Consumption_and_Risk_of_Coronary_Heart_Disease_in_a_Large_Italian_Cohort">Espresso Coffee Consumption and Risk of Coronary Heart Disease in a Large Italian Cohort</a></div><div class="wp-workCard_item"><span>PLOS ONE</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The relationship between coffee consumption and coronary heart disease (CHD) has been investigate...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We examined the association between Italian-style (espresso and mocha) coffee consumption and CHD risk. We investigated 12,800 men and 30,449 women without history of cardiovascular disease recruited to the EPICOR prospective cohort study. Coffee consumption was assessed at baseline. In a random sub-cohort of 1472 subjects, plasma triglycerides, and total, LDL and HDL cholesterol were determined to investigate the effect of coffee consumption on plasma lipids. After a mean follow up of 10.9 years, 804 cases of CHD (500 acute events, 56 fatal events and 248 revascularizations, all first events) were identified. Multivariable adjusted hazard ratios for CHD were: 1.18 (95% CI 0.87-1.60) for drinking 1-2 cups/day, 1.37 (95% CI 1.03-1.82) for &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;2-4 cups/day and 1.52 (95% CI 1.11-2.07) for over 4 cups/day (P trend &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001) compared to reference (&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;1 cup/day). Plasma triglycerides, and total, LDL and HDL cholesterol did not vary significantly (ANOVA) with coffee consumption. Consumption of over 2 cups/day of Italian-style coffee is associated with increased CHD risk, but coffee consumption was not associated with plasma lipid changes, so the adverse effect of consumption appears unrelated to lipid profile.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608784"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608784"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608784; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608784]").text(description); $(".js-view-count[data-work-id=19608784]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608784; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608784']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608784]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608784,"title":"Espresso Coffee Consumption and Risk of Coronary Heart Disease in a Large Italian Cohort","internal_url":"https://www.academia.edu/19608784/Espresso_Coffee_Consumption_and_Risk_of_Coronary_Heart_Disease_in_a_Large_Italian_Cohort","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608783"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608783/Aging_and_tissue_plasminogen_activator_release"><img alt="Research paper thumbnail of Aging and tissue plasminogen activator release" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608783/Aging_and_tissue_plasminogen_activator_release">Aging and tissue plasminogen activator release</a></div><div class="wp-workCard_item"><span>Thrombosis and Haemostasis</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608783"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608783"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608783; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608783]").text(description); $(".js-view-count[data-work-id=19608783]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608783; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608783']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608783]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608783,"title":"Aging and tissue plasminogen activator release","internal_url":"https://www.academia.edu/19608783/Aging_and_tissue_plasminogen_activator_release","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608782"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608782/Prolongation_of_bleeding_time_by_acute_hemolysis_in_rats_a_role_for_nitric_oxide"><img alt="Research paper thumbnail of Prolongation of bleeding time by acute hemolysis in rats: a role for nitric oxide" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608782/Prolongation_of_bleeding_time_by_acute_hemolysis_in_rats_a_role_for_nitric_oxide">Prolongation of bleeding time by acute hemolysis in rats: a role for nitric oxide</a></div><div class="wp-workCard_item"><span>The American journal of physiology</span><span>, 1997</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The present study was aimed at clarifying the interaction between red blood cell trauma and bleed...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The present study was aimed at clarifying the interaction between red blood cell trauma and bleeding observed in some clinical conditions. Acute hemolysis provoked by distilled water injection was followed by a significant prolongation of the &quot;template&quot; bleeding time in rats. Comparable effects were observed after injection of an isotonic lysate of washed red blood cells. N omega-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) formation from L-arginine, normalized bleeding time when given to rats before hemolysis induction. The occurrence of hemolysis decreased ex vivo platelet adhesion to collagen without affecting platelet aggregation and induced a transient drop in blood pressure, the latter occurring during the first minute after injection. L-NAME pretreatment increased ex vivo platelet adhesion but did not affect either platelet aggregation or fall in blood pressure. All the effects of L-NAME were blunted by treating the animals with the NO p...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608782"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608782"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608782; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608782]").text(description); $(".js-view-count[data-work-id=19608782]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608782; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608782']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608782]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608782,"title":"Prolongation of bleeding time by acute hemolysis in rats: a role for nitric oxide","internal_url":"https://www.academia.edu/19608782/Prolongation_of_bleeding_time_by_acute_hemolysis_in_rats_a_role_for_nitric_oxide","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608781"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608781/Cathepsin_G_induced_release_of_PAI_1_in_the_culture_medium_of_endothelial_cells_a_new_thrombogenic_role_for_polymorphonuclear_leukocytes"><img alt="Research paper thumbnail of Cathepsin G--induced release of PAI-1 in the culture medium of endothelial cells: a new thrombogenic role for polymorphonuclear leukocytes?" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608781/Cathepsin_G_induced_release_of_PAI_1_in_the_culture_medium_of_endothelial_cells_a_new_thrombogenic_role_for_polymorphonuclear_leukocytes">Cathepsin G--induced release of PAI-1 in the culture medium of endothelial cells: a new thrombogenic role for polymorphonuclear leukocytes?</a></div><div class="wp-workCard_item"><span>The Journal of laboratory and clinical medicine</span><span>, 1993</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Activated polymorphonuclear leukocytes (PMNs) may affect the integrity of blood vessels by endoth...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Activated polymorphonuclear leukocytes (PMNs) may affect the integrity of blood vessels by endothelial cell injury. We investigated the effects of cathepsin G purified from human neutrophils on the fibrinolytic potential of cultured human umbilical vein endothelial cells (HUVECs). Cathepsin G (5 and 10 micrograms/ml) induced marked intercellular gap formation after 1 hour of treatment, whereas 1 microgram/ml did not, even after 6 hours incubation. In contrast, plasminogen activator inhibitor-1 (PAI-1) antigen levels, measured by a double antibody enzyme-linked immunosorbent assay, were significantly increased in culture media (CM) on cathepsin G (1 microgram/ml) treatment after 15 minutes (5.1 +/- 1.2 ng/ml vs 2.6 +/- 0.6 ng/ml for controls, p &lt; 0.01) and 6 hours of incubation (69.6 +/- 17.5 ng/ml vs 40.0 +/- 9.0 ng/ml for controls, p &lt; 0.01). Likewise, PAI activity, measured by reverse fibrin autography, increased on cell treatment with cathepsin G. Preincubation of cathepsin...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608781"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608781"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608781; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608781]").text(description); $(".js-view-count[data-work-id=19608781]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608781; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608781']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608781]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608781,"title":"Cathepsin G--induced release of PAI-1 in the culture medium of endothelial cells: a new thrombogenic role for polymorphonuclear leukocytes?","internal_url":"https://www.academia.edu/19608781/Cathepsin_G_induced_release_of_PAI_1_in_the_culture_medium_of_endothelial_cells_a_new_thrombogenic_role_for_polymorphonuclear_leukocytes","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608780"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608780/The_Mediterranean_diet_the_reasons_for_a_success"><img alt="Research paper thumbnail of The Mediterranean diet: the reasons for a success" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608780/The_Mediterranean_diet_the_reasons_for_a_success">The Mediterranean diet: the reasons for a success</a></div><div class="wp-workCard_item"><span>Thrombosis research</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">There is a substantial body of evidence linking Mediterranean Diet to cardiovascular risk reducti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">There is a substantial body of evidence linking Mediterranean Diet to cardiovascular risk reduction and prevention of the major chronic diseases. Nevertheless Mediterranean societies are rapidly withdrawing from this eating pattern orienting their food choices toward products typical of the Western diet pattern, which is rich in refined grains, animal fats, sugars, processed meat but are quite poor in legumes, cereals, fruits and vegetables. The reasons people keep on shifting from healthy to unhealthy dietary habits remain open to several interpretations. Social changes appear to have consistently contributed to radical reversal in dietary habits in European Mediterranean societies even though developing Countries are somewhat turning into westernized diets as well. Among possible causes, increasing prices of some of the major food items of Mediterranean pyramid seem to have led people to give up this eating pattern in favor of less expensive products which allow to save money but ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608780"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608780"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608780; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608780]").text(description); $(".js-view-count[data-work-id=19608780]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608780; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608780']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608780]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608780,"title":"The Mediterranean diet: the reasons for a success","internal_url":"https://www.academia.edu/19608780/The_Mediterranean_diet_the_reasons_for_a_success","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608779"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19608779/Analysis_of_675_4_g_5_G_SERPINE1_and_C_159T_CD14_polymorphisms_in_house_dust_mite_allergic_asthma_patients"><img alt="Research paper thumbnail of Analysis of -675 4 g/5 G SERPINE1 and C-159T CD14 polymorphisms in house dust mite-allergic asthma patients" class="work-thumbnail" src="https://attachments.academia-assets.com/42072736/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19608779/Analysis_of_675_4_g_5_G_SERPINE1_and_C_159T_CD14_polymorphisms_in_house_dust_mite_allergic_asthma_patients">Analysis of -675 4 g/5 G SERPINE1 and C-159T CD14 polymorphisms in house dust mite-allergic asthma patients</a></div><div class="wp-workCard_item"><span>Journal of investigational allergology & clinical immunology</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Experimental studies indicate that endogenous plasminogen activator inhibitor-1 (PAI-1, encoded b...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Experimental studies indicate that endogenous plasminogen activator inhibitor-1 (PAI-1, encoded by the gene SERPINE1) modulates the immune response to lipopolysaccharide (LPS). On the other hand, LPS induces PAI-1 secretion. Activation of individual cells by LPS is facilitated by CD14. The single nucleotide polymorphisms -675 4G/5G in SERPINE1 and C-159T in CD14 are major determinants of PAI-1 and CD14 expression, respectively. To evaluate the frequency of the -675 4G/5G SERPINE1 and C-159T CD14 polymorphisms in house dust mite (HDM) allergic asthma patients. The polymorphisms were evaluated in unrelated inhabitants of northeastern Poland, including 372 HDM-allergic asthmatic patients and 160 healthy nonatopic control subjects using polymerase chain reaction. Both the C allele of CD14 and the 4G allele of SERPINE1 were more frequently encountered in HDM-allergic asthmatic patients than in healthy control individuals. When the 5G/5G-TT/CT genotype was considered as a nonrisk genotype...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="24aed632e6c6c470aee6272438381a79" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42072736,"asset_id":19608779,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42072736/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608779"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608779"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608779; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608779]").text(description); $(".js-view-count[data-work-id=19608779]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608779; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608779']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "24aed632e6c6c470aee6272438381a79" } } $('.js-work-strip[data-work-id=19608779]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608779,"title":"Analysis of -675 4 g/5 G SERPINE1 and C-159T CD14 polymorphisms in house dust mite-allergic asthma patients","internal_url":"https://www.academia.edu/19608779/Analysis_of_675_4_g_5_G_SERPINE1_and_C_159T_CD14_polymorphisms_in_house_dust_mite_allergic_asthma_patients","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[{"id":42072736,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42072736/thumbnails/1.jpg","file_name":"Analysis_of_-675_4G5G_SERPINE1_and_C-15920160204-9568-1lnv8vi.pdf","download_url":"https://www.academia.edu/attachments/42072736/download_file","bulk_download_file_name":"Analysis_of_675_4_g_5_G_SERPINE1_and_C_1.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42072736/Analysis_of_-675_4G5G_SERPINE1_and_C-15920160204-9568-1lnv8vi-libre.pdf?1454614178=\u0026response-content-disposition=attachment%3B+filename%3DAnalysis_of_675_4_g_5_G_SERPINE1_and_C_1.pdf\u0026Expires=1739725481\u0026Signature=fkiyMuhMu82TW~ufvIR1Bl~S943Sws0PwyEDDd-GDjXInj9L~pq5vz8vXGlNySmOYb8uo6FOGY2Qbr1ZfPIvNVru6KBtw2guqMw6Vmrxb23g3GmCDW2TW-7tXaXWqSDJN8i~-msj2sy85MARPF4BNIs8qgKjidn7OJIGApBvhYuFNuwQTFyWwqGlfp4AFnU6ApEzywzhYgL1Ia8QE3VPjocKXgBWrGnDD68prOzu9BS33BWSA1CxgIfGK98LzITO4sNuTW-dc35Zfz3wz~PmDEI0AjqR5Sz7xwWRBU8YcSpT~kDKaAt32hNY6XVmkbWV8e~GA5-JN~biiRp3glmCCA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608778"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19608778/The_E27_beta2_adrenergic_receptor_polymorphism_reduces_the_risk_of_myocardial_infarction_in_dyslipidemic_young_males"><img alt="Research paper thumbnail of The E27 beta2-adrenergic receptor polymorphism reduces the risk of myocardial infarction in dyslipidemic young males" class="work-thumbnail" src="https://attachments.academia-assets.com/42072738/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19608778/The_E27_beta2_adrenergic_receptor_polymorphism_reduces_the_risk_of_myocardial_infarction_in_dyslipidemic_young_males">The E27 beta2-adrenergic receptor polymorphism reduces the risk of myocardial infarction in dyslipidemic young males</a></div><div class="wp-workCard_item"><span>Thrombosis and haemostasis</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the present study we evaluated whether two polymorphisms of beta2-adrenergic receptors (beta2-...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the present study we evaluated whether two polymorphisms of beta2-adrenergic receptors (beta2-AR) gene (R16G and Q27E) could modify the risk of myocardial infarction (MI). Using a case-control design, we analyzed the data from 125 male patients who had experienced a first episode of MI before the age of 45 years and 108 male controls matched for age. The allele frequencies for R16G and Q27E were: G16=0.56 and E27=0.36 in patients with MI and G16=0.61 and E27=0.42 in the control group. There was a trend (not statistically significant) of decreasing MI risk according to E27 or G16 alleles. Combined effect between E27 allele and history of dyslipidemia has been observed. Whereas dyslipidemia conferred a relative risk of MI of 4.8 (P&lt;0.001) compared with normolipidemia in the entire study population, the relative risk increased to 9.0 (P&lt;0.001) in Q27 homozygotes with dyslipidemia, and decreased to 1.8 (P=0.36) in E27 homozygotes. Our results show that the E27 allele of the bet...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6223154c76739b49a66d42628d46bd60" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42072738,"asset_id":19608778,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42072738/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608778"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608778"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608778; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608775"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608775/Reduced_pulmonary_metastases_of_lewis_lung_carcinoma_in_hPAI_1_transgenic_mice"><img alt="Research paper thumbnail of Reduced pulmonary metastases of lewis lung carcinoma in hPAI-1 transgenic mice" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608775/Reduced_pulmonary_metastases_of_lewis_lung_carcinoma_in_hPAI_1_transgenic_mice">Reduced pulmonary metastases of lewis lung carcinoma in hPAI-1 transgenic mice</a></div><div class="wp-workCard_item"><span>Fibrinolysis</span><span>, 1994</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608775"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608775"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608775; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608775]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608775,"title":"Reduced pulmonary metastases of lewis lung carcinoma in hPAI-1 transgenic mice","internal_url":"https://www.academia.edu/19608775/Reduced_pulmonary_metastases_of_lewis_lung_carcinoma_in_hPAI_1_transgenic_mice","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608774"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608774/Prostacyclin_is_required_for_t_PA_release_after_venous_occlusion"><img alt="Research paper thumbnail of Prostacyclin is required for t-PA release after venous occlusion" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608774/Prostacyclin_is_required_for_t_PA_release_after_venous_occlusion">Prostacyclin is required for t-PA release after venous occlusion</a></div><div class="wp-workCard_item"><span>The American journal of physiology</span><span>, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The role of vascular cyclooxygenase pathway on tissue-type plasminogen activator (t-PA) release a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The role of vascular cyclooxygenase pathway on tissue-type plasminogen activator (t-PA) release after venous occlusion was studied in anesthetized rats. After the inferior vena cava was clamped for 30 min, fibrinolytic activity increased from 143.7 +/- 14.5 to 209.5 +/- 10.3 mm2 (mean +/- SE, P &lt; 0.002). This increase was prevented by aspirin at high (100 mg/kg i.v.) but not at low doses (1 mg/kg i.v.). Dazoxiben (10 mg/kg i.v.), an inhibitor of thromboxane synthase, was ineffective on the fibrinolytic response. Both the basal levels of 6-ketoprostaglandin F1 alpha and its increase after venous occlusion were suppressed by 100 mg/kg aspirin administration (from 0.64 +/- 0.2 to 0.05 +/- 0.002 ng/ml before occlusion, P &lt; 0.001; and from 1.08 +/- 0.2 to 0.06 +/- 0.002 ng/kg after occlusion, P &lt; 0.001), whereas they were both unaffected by aspirin at low doses (from 0.53 +/- 0.06 before to 1.20 +/- 0.08 ng/ml after stasis). Moreover, iloprost, a stable analogue of prostacyclin,...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608774"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608774"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608774; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608774]").text(description); $(".js-view-count[data-work-id=19608774]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608774; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608774']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608774]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608774,"title":"Prostacyclin is required for t-PA release after venous occlusion","internal_url":"https://www.academia.edu/19608774/Prostacyclin_is_required_for_t_PA_release_after_venous_occlusion","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608773"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608773/Enhanced_vascular_plasminogen_activator_t_PA_release_by_epinephrine_in_aged_rats"><img alt="Research paper thumbnail of Enhanced vascular plasminogen activator (t-PA) release by epinephrine in aged rats" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608773/Enhanced_vascular_plasminogen_activator_t_PA_release_by_epinephrine_in_aged_rats">Enhanced vascular plasminogen activator (t-PA) release by epinephrine in aged rats</a></div><div class="wp-workCard_item"><span>Thrombosis and haemostasis</span><span>, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Adrenergic stimulation induces an acute fibrinolytic response in the vascular wall and can play a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Adrenergic stimulation induces an acute fibrinolytic response in the vascular wall and can play an important role in limiting thrombus growth. The incidence of thrombotic disease increases with age. As many adrenergic functions are affected by aging, the vascular response to adrenergic stimulation was studied in young (3 +/- 1 months) and aged (18 +/- 3 months) rats, using an experimental model of vascular perfusion. Five min epinephrine (EPI) infusion (0.15-25 microM) induced a dose-dependent increase in tissue-type plasminogen activator (t-PA) release and in perfusion pressure, in both young and aged rats. In the latter, however, the basal activity of t-PA was significantly higher than in young animals (0.22 +/- 0.02 vs 0.13 +/- 0.01 U/ml; means +/- SE; p &lt; 0.01, n = 40) and EPI infusion induced a significantly higher increase in t-PA activity (0.78 +/- 0.06 vs 0.47 +/- 0.08 U/ml, p &lt; 0.01, for 6.25 microM EPI). The response was characterized by a delayed onset. In contrast,...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608773"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608773"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608773; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608773]").text(description); $(".js-view-count[data-work-id=19608773]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608773; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608773']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608773]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608773,"title":"Enhanced vascular plasminogen activator (t-PA) release by epinephrine in aged rats","internal_url":"https://www.academia.edu/19608773/Enhanced_vascular_plasminogen_activator_t_PA_release_by_epinephrine_in_aged_rats","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608772"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19608772/T_wave_axis_deviation_metabolic_syndrome_and_cardiovascular_risk_results_from_the_MOLI_SANI_study"><img alt="Research paper thumbnail of T-wave axis deviation, metabolic syndrome and cardiovascular risk: results from the MOLI-SANI study" class="work-thumbnail" src="https://attachments.academia-assets.com/42072761/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19608772/T_wave_axis_deviation_metabolic_syndrome_and_cardiovascular_risk_results_from_the_MOLI_SANI_study">T-wave axis deviation, metabolic syndrome and cardiovascular risk: results from the MOLI-SANI study</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Early recognition of patients at increased cardiovascular risk is a major challenge. The surface ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Early recognition of patients at increased cardiovascular risk is a major challenge. The surface electrocardiogram provides a useful platform and it has been used to propose several indexes. T wave axis abnormality is associated with an increased risk of cardiovascular mortality, independently of other risk factors and can be associated with the presence of the metabolic syndrome (MetS). We assessed the prevalence of T axis abnormalities and its relationship with MetS and its components in a large population of Italian adults. Data concerning 11,143 women (54 ± 11 years) and 9742 men (55 ± 11 years) randomly recruited from a general population (Moli-sani cohort) were analyzed. After excluding subjects with incomplete data and with history of cardiac disease or left ventricular hypertrophy, T-wave axis was normal in 74.5% of men and 80.9% of women, borderline in 23.6% and 17.3% and abnormal in 1.9% and 1.8%. In subjects with MetS, the prevalence of borderline or abnormal T-wave axis deviation was higher than in subjects without MetS (in men: 26.6% vs. 22.1% and 2.5% vs. 1.7%; in women: 25% vs. 15% and 2.4% vs. 1.6%, respectively for borderline and abnormal levels, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.0001). Each component of MetS increased the odds of having borderline or abnormal T-wave axis deviation by 1.21 in men and 1.31 in women. T wave axis deviation is associated with MetS and its individual components. These findings confirm previous reported results, expanding them to a large and representative sample of European population of Caucasian ethnicity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eda9941b6228b5804ea252e8c2d3edf2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42072761,"asset_id":19608772,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42072761/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608772"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608772"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608772; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608772]").text(description); $(".js-view-count[data-work-id=19608772]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608772; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608772']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "eda9941b6228b5804ea252e8c2d3edf2" } } $('.js-work-strip[data-work-id=19608772]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608772,"title":"T-wave axis deviation, metabolic syndrome and cardiovascular risk: results from the MOLI-SANI study","internal_url":"https://www.academia.edu/19608772/T_wave_axis_deviation_metabolic_syndrome_and_cardiovascular_risk_results_from_the_MOLI_SANI_study","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[{"id":42072761,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42072761/thumbnails/1.jpg","file_name":"j.jelectrocard.2012.07.019.pdf20160204-22322-ozbkc9","download_url":"https://www.academia.edu/attachments/42072761/download_file","bulk_download_file_name":"T_wave_axis_deviation_metabolic_syndrome.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42072761/j.jelectrocard.2012.07.019-libre.pdf20160204-22322-ozbkc9?1454614175=\u0026response-content-disposition=attachment%3B+filename%3DT_wave_axis_deviation_metabolic_syndrome.pdf\u0026Expires=1739725481\u0026Signature=QCHgyf0YH8el1A9oDwPwGZ6U1Isf4apYKmUs5ziYFMO2MiP9iK1ZxDhfGuctF0qscwyBUsqrPQnbKng-zNsjgfHg8OCJsg3fGxLbGbe9s3QyeaIK6y~vPTnTUdEe2J19iC79ShlmHye6SEZWcDqb6gplSYqGuxtbLhICmn8P~PUsAqGNKohTrDh9f10fqHdalENoZ6CQLUh8IsVt6r9BfBhsEg9Y9NzaLahg60e~eK3ZjW4vELfBtxdn3YeOWhUCVI~TGhi3az5zAPu0YVSYKcq4Z0z93hrgX3hXMLUPev6S2uQEMairuZz1F2Mp3XLeR2aMFMyOhH2Dv2rd7lIoJw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608771"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19608771/The_Moli_sani_project_computerized_ECG_database_in_a_population_based_cohort_study"><img alt="Research paper thumbnail of The Moli-sani project: computerized ECG database in a population-based cohort study" class="work-thumbnail" src="https://attachments.academia-assets.com/40730296/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19608771/The_Moli_sani_project_computerized_ECG_database_in_a_population_based_cohort_study">The Moli-sani project: computerized ECG database in a population-based cohort study</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Computerized electrocardiogram (ECG) acquisition and interpretation may be extremely useful in ha...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Computerized electrocardiogram (ECG) acquisition and interpretation may be extremely useful in handling analysis of data from large cohort studies and exploit research on the use of ECG data as prognostic markers for cardiovascular disease. The Moli-sani project (<a href="http://www.moli-sani.org" rel="nofollow">http://www.moli-sani.org</a>) is a population-based cohort study aiming at evaluating the risk factors linked to chronic-degenerative disease with particular regard to cardiovascular disease and cancer and intermediate metabolic phenotypes such as hypertension, diabetes, dyslipidemia, obesity, and metabolic syndrome. Between March 2005 and April 2010, 24 325 people aged 35 years or older, living in the Molise region (Italy), were randomly recruited. A follow-up based on linkage with hospital discharge records and mortality regional registry and reexamination of the cohort is ongoing and will be repeated at prefixed times. Each subject was administered questionnaires on personal and medical history, food consumption, quality of life (FS36), and psychometry. Plasma serum, cellular pellet, and urinary spots were stored in liquid nitrogen. Subjects were measured blood pressure, weight, height, and waist and hip circumferences, and underwent spirometry to evaluate pulmonary diffusion capacity, gas diffusion, and pulmonary volumes. Standard 12-lead resting ECG was performed by a Cardiette ar2100-view electrocardiograph and tracings stored in digital standard communication protocol format for subsequent analysis. The digital ECG database of the Moli-sani project is currently being used to assess the association between physiologic variables and pathophyiosiologic conditions and parameters derived from the ECG signal. This computerized ECG database represents a unique opportunity to identify and assess prognostic factors associated with cardiovascular and metabolic diseases.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cb152efac64bfff67bf56a4169169e82" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":40730296,"asset_id":19608771,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/40730296/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608771"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608771"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608771; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608771]").text(description); $(".js-view-count[data-work-id=19608771]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608771; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608771']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cb152efac64bfff67bf56a4169169e82" } } $('.js-work-strip[data-work-id=19608771]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608771,"title":"The Moli-sani project: computerized ECG database in a population-based cohort study","internal_url":"https://www.academia.edu/19608771/The_Moli_sani_project_computerized_ECG_database_in_a_population_based_cohort_study","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[{"id":40730296,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/40730296/thumbnails/1.jpg","file_name":"j.jelectrocard.2012.07.008.pdf20151211-17754-10jn2ob","download_url":"https://www.academia.edu/attachments/40730296/download_file","bulk_download_file_name":"The_Moli_sani_project_computerized_ECG_d.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/40730296/j.jelectrocard.2012.07.008-libre.pdf20151211-17754-10jn2ob?1449848836=\u0026response-content-disposition=attachment%3B+filename%3DThe_Moli_sani_project_computerized_ECG_d.pdf\u0026Expires=1739725481\u0026Signature=FWqBsd-cwmRbz6I~D15KZwtWS3Yd9pL8yE4WoQRDRjVcc6oF55Tid0rRIeZBskqs24JppeKR1BfQkoyTuEqE6FLl3JZs2VqW9gUUn5SvGpKYdapAnZfct9s1DI7njwv8bJe1x1GT66baAPBRg7MAq7Rp6rEPb8vGPmZUKJDm2gUlFFyAnfp-cYnqXrE3eWdE~aiWF-Ys1yCvBrpqWi7UA6CjDgwfCdC8zCS1Mc39CkSE8~7XCdrVL0J9RVubku9smv8nT2eb2aWOGBnfttVBig~XaZA062-dmUhLyPHEmhuldDld3GzfRLq7idUdgTd7bohxqdLISBj8wM4GDCm3TA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608770"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19608770/Prevalence_and_cardiovascular_risk_profile_of_chronic_kidney_disease_in_Italy_results_of_the_2008_12_National_Health_Examination_Survey"><img alt="Research paper thumbnail of Prevalence and cardiovascular risk profile of chronic kidney disease in Italy: results of the 2008-12 National Health Examination Survey" class="work-thumbnail" src="https://attachments.academia-assets.com/42072747/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19608770/Prevalence_and_cardiovascular_risk_profile_of_chronic_kidney_disease_in_Italy_results_of_the_2008_12_National_Health_Examination_Survey">Prevalence and cardiovascular risk profile of chronic kidney disease in Italy: results of the 2008-12 National Health Examination Survey</a></div><div class="wp-workCard_item"><span>Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association</span><span>, Jan 18, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">National surveys in countries outside Europe have reported a high prevalence (11-13%) of chronic ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">National surveys in countries outside Europe have reported a high prevalence (11-13%) of chronic kidney disease (CKD). Studies in Europe have provided a variable prevalence likely due to differences in study design, including age and extent of geographic areas, equation used to evaluate estimated glomerular filtration rate (eGFR) and CKD stages examined. The 2008-12 National Health Examination Survey in Italy randomly extracted samples from the general population aged 35-79 years, stratified by age and gender, from the resident list of each Italian region (440 persons/1.5 million of residents). We estimated the prevalence of CKD by means of urinary albumin : creatinine ratio and eGFR (CKD-EPI equation-enzymatic assay of serum creatinine). Cardiovascular (CV) risk profile was also evaluated. Three thousand eight hundred and forty-eight men and 3704 women were examined. In the whole population, mean age was 57 ± 12 and 56 ± 12 years in men and women, respectively; hypertension was pre...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="001be4f8a79db581372e909e5e173fa9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42072747,"asset_id":19608770,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42072747/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608770"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608770"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608770; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608770]").text(description); $(".js-view-count[data-work-id=19608770]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608770; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608770']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "001be4f8a79db581372e909e5e173fa9" } } $('.js-work-strip[data-work-id=19608770]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608770,"title":"Prevalence and cardiovascular risk profile of chronic kidney disease in Italy: results of the 2008-12 National Health Examination Survey","internal_url":"https://www.academia.edu/19608770/Prevalence_and_cardiovascular_risk_profile_of_chronic_kidney_disease_in_Italy_results_of_the_2008_12_National_Health_Examination_Survey","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[{"id":42072747,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42072747/thumbnails/1.jpg","file_name":"ndt.gfu383.full.pdf","download_url":"https://www.academia.edu/attachments/42072747/download_file","bulk_download_file_name":"Prevalence_and_cardiovascular_risk_profi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42072747/ndt.gfu383.full-libre.pdf?1454614177=\u0026response-content-disposition=attachment%3B+filename%3DPrevalence_and_cardiovascular_risk_profi.pdf\u0026Expires=1739725481\u0026Signature=eQ71V~Dgej7hbfyOG1btbOpR4kXQK6Beovs-XtL3qivc-yQK4gCygdkvYDi9h63E8gHXQeGEsjm-4o3xyJs7bOKTxBnenG61iK28vWg8QMdqqhc0MFMEbNWl3kQBjXf9hqu6dUrY6sprI9MlWVzqzj184SUyHHncVPC9fKaoG~dvWT3xjfXOlaUk8EuN-abIpXHtR-j8YkBaXRm5KxKtMHysgES~lzq59NEwqAzomGxnEj9YOCzSzw9hUDZlpWr9BeY8N12mYzb5BcINyf6ArMPjBhFNn1MmwbTKwroo6BXNqLOqyLJNwOOWW4NtODqBYcHdqTvqZBtdpAbmSAWPIg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608769"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608769/Analysis_of_gene_environment_interaction_in_coronary_heart_disease_fibrinogen_polymorphisms_as_an_example"><img alt="Research paper thumbnail of Analysis of gene-environment interaction in coronary heart disease: fibrinogen polymorphisms as an example" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608769/Analysis_of_gene_environment_interaction_in_coronary_heart_disease_fibrinogen_polymorphisms_as_an_example">Analysis of gene-environment interaction in coronary heart disease: fibrinogen polymorphisms as an example</a></div><div class="wp-workCard_item"><span>Italian heart journal : official journal of the Italian Federation of Cardiology</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Several epidemiological studies have shown that an increase in fibrinogen levels is associated wi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Several epidemiological studies have shown that an increase in fibrinogen levels is associated with the risk of cardiovascular disease. Recently, it has been demonstrated that the levels of fibrinogen can be genetically determined. Overall the studies show a strong association between two polymorphisms of the fibrinogen beta-chain gene and fibrinogen plasma concentration. Few studies have, in contrast, found an association between such polymorphisms and the risk of ischemic vascular disease. Rather than directly affecting the levels of proteins or the risk of disease, polymorphisms can amplify the effect of environmental or intermediate conditions on the final phenotype. The genetic control of fibrinogen has to be considered together with environmental factors: fibrinogen genotypes may interact with cigarette smoking, gender, physical activity, use of drugs and infections in determining the increase in fibrinogen levels and perhaps the risk of ischemic heart disease. Three examples ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608769"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608769"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608769; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608769]").text(description); $(".js-view-count[data-work-id=19608769]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608769; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608769']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608769]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608769,"title":"Analysis of gene-environment interaction in coronary heart disease: fibrinogen polymorphisms as an example","internal_url":"https://www.academia.edu/19608769/Analysis_of_gene_environment_interaction_in_coronary_heart_disease_fibrinogen_polymorphisms_as_an_example","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608768"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19608768/Regular_consumption_of_dark_chocolate_is_associated_with_low_serum_concentrations_of_C_reactive_protein_in_a_healthy_Italian_population"><img alt="Research paper thumbnail of Regular consumption of dark chocolate is associated with low serum concentrations of C-reactive protein in a healthy Italian population" class="work-thumbnail" src="https://attachments.academia-assets.com/42072744/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19608768/Regular_consumption_of_dark_chocolate_is_associated_with_low_serum_concentrations_of_C_reactive_protein_in_a_healthy_Italian_population">Regular consumption of dark chocolate is associated with low serum concentrations of C-reactive protein in a healthy Italian population</a></div><div class="wp-workCard_item"><span>The Journal of nutrition</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dark chocolate contains high concentrations of flavonoids and may have antiinflammatory propertie...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dark chocolate contains high concentrations of flavonoids and may have antiinflammatory properties. We evaluated the association of dark chocolate intake with serum C-reactive protein (CRP). The Moli-sani Project is an ongoing cohort study of men and women aged &gt;/=35 y randomly recruited from the general population. By July 2007, 10,994 subjects had been enrolled. Of 4849 subjects apparently free of any chronic disease, 1317 subjects who declared having eaten any chocolate during the past year (mean age 53 +/- 12 y; 51% men) and 824 subjects who ate chocolate regularly in the form of dark chocolate only (50 +/- 10 y; 55% men) were selected. High sensitivity-CRP was measured by an immunoturbidimetric method. The European Prospective Investigation into Cancer and Nutrition FFQ was used to evaluate nutritional intake. After adjustment for age, sex, social status, physical activity, systolic blood pressure, BMI, waist:hip ratio, food groups, and total energy intake, dark chocolate co...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5b6222ab0bf1691ef383a7e88ae394c4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42072744,"asset_id":19608768,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42072744/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608768"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608768"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608768; 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Refdoc est un service / is powered by. ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608767"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608767"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608767; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608767]").text(description); $(".js-view-count[data-work-id=19608767]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608767; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608767']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608767]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608767,"title":"PFA-100 closure time to predict cardiovascular events in aspirin-treated cardiovascular patients: A meta-analysis of 19 studies comprising 3,003 patients","internal_url":"https://www.academia.edu/19608767/PFA_100_closure_time_to_predict_cardiovascular_events_in_aspirin_treated_cardiovascular_patients_A_meta_analysis_of_19_studies_comprising_3_003_patients","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="4256103" id="papers"><div class="js-work-strip profile--work_container" data-work-id="19608786"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608786/Genetic_and_environmental_influences_on_body_mass_index_in_European_children"><img alt="Research paper thumbnail of Genetic and environmental influences on body mass index in European children" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608786/Genetic_and_environmental_influences_on_body_mass_index_in_European_children">Genetic and environmental influences on body mass index in European children</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608786"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608786"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608786; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608786]").text(description); $(".js-view-count[data-work-id=19608786]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608786; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608786']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608786]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608786,"title":"Genetic and environmental influences on body mass index in European children","internal_url":"https://www.academia.edu/19608786/Genetic_and_environmental_influences_on_body_mass_index_in_European_children","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608785"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608785/Metabolic_syndrome_and_breast_cancer_risk_a_case_cohort_study_nested_in_a_multicentre_italian_cohort"><img alt="Research paper thumbnail of Metabolic syndrome and breast cancer risk: a case-cohort study nested in a multicentre italian cohort" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608785/Metabolic_syndrome_and_breast_cancer_risk_a_case_cohort_study_nested_in_a_multicentre_italian_cohort">Metabolic syndrome and breast cancer risk: a case-cohort study nested in a multicentre italian cohort</a></div><div class="wp-workCard_item"><span>PloS one</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Metabolic syndrome (defined as at least three among abdominal obesity, high blood triglycerides, ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Metabolic syndrome (defined as at least three among abdominal obesity, high blood triglycerides, low high-density lipoprotein cholesterol, high blood glucose, and high blood pressure) is emerging as a risk factor for breast cancer; however few studies - most confined to postmenopausal women - have investigated associations between breast cancer risk and metabolic syndrome. The purpose of this study was to examine the association between metabolic syndrome and its components, and risk of breast cancer in postmenopausal and premenopausal women. We performed a case-cohort study on 22,494 women recruited in 1993-1998 to four Italian centres (Turin, Varese, Naples, Ragusa) of the European Prospective Investigation into Cancer and Nutrition (EPIC) and followed-up for up to 15 years. A random subcohort of 565 women was obtained and 593 breast cancer cases were diagnosed. Hazard ratios (HR) with 95% confidence intervals (CI), adjusted for potential confounders, were estimated by Prentice-we...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608785"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608785"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608785; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608785]").text(description); $(".js-view-count[data-work-id=19608785]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608785; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608785']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608785]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608785,"title":"Metabolic syndrome and breast cancer risk: a case-cohort study nested in a multicentre italian cohort","internal_url":"https://www.academia.edu/19608785/Metabolic_syndrome_and_breast_cancer_risk_a_case_cohort_study_nested_in_a_multicentre_italian_cohort","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608784"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608784/Espresso_Coffee_Consumption_and_Risk_of_Coronary_Heart_Disease_in_a_Large_Italian_Cohort"><img alt="Research paper thumbnail of Espresso Coffee Consumption and Risk of Coronary Heart Disease in a Large Italian Cohort" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608784/Espresso_Coffee_Consumption_and_Risk_of_Coronary_Heart_Disease_in_a_Large_Italian_Cohort">Espresso Coffee Consumption and Risk of Coronary Heart Disease in a Large Italian Cohort</a></div><div class="wp-workCard_item"><span>PLOS ONE</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The relationship between coffee consumption and coronary heart disease (CHD) has been investigate...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The relationship between coffee consumption and coronary heart disease (CHD) has been investigated in several studies with discrepant results. We examined the association between Italian-style (espresso and mocha) coffee consumption and CHD risk. We investigated 12,800 men and 30,449 women without history of cardiovascular disease recruited to the EPICOR prospective cohort study. Coffee consumption was assessed at baseline. In a random sub-cohort of 1472 subjects, plasma triglycerides, and total, LDL and HDL cholesterol were determined to investigate the effect of coffee consumption on plasma lipids. After a mean follow up of 10.9 years, 804 cases of CHD (500 acute events, 56 fatal events and 248 revascularizations, all first events) were identified. Multivariable adjusted hazard ratios for CHD were: 1.18 (95% CI 0.87-1.60) for drinking 1-2 cups/day, 1.37 (95% CI 1.03-1.82) for &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;2-4 cups/day and 1.52 (95% CI 1.11-2.07) for over 4 cups/day (P trend &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001) compared to reference (&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;1 cup/day). Plasma triglycerides, and total, LDL and HDL cholesterol did not vary significantly (ANOVA) with coffee consumption. Consumption of over 2 cups/day of Italian-style coffee is associated with increased CHD risk, but coffee consumption was not associated with plasma lipid changes, so the adverse effect of consumption appears unrelated to lipid profile.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608784"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608784"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608784; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608784]").text(description); $(".js-view-count[data-work-id=19608784]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608784; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608784']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608784]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608784,"title":"Espresso Coffee Consumption and Risk of Coronary Heart Disease in a Large Italian Cohort","internal_url":"https://www.academia.edu/19608784/Espresso_Coffee_Consumption_and_Risk_of_Coronary_Heart_Disease_in_a_Large_Italian_Cohort","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608783"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608783/Aging_and_tissue_plasminogen_activator_release"><img alt="Research paper thumbnail of Aging and tissue plasminogen activator release" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608783/Aging_and_tissue_plasminogen_activator_release">Aging and tissue plasminogen activator release</a></div><div class="wp-workCard_item"><span>Thrombosis and Haemostasis</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608783"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608783"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608783; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608783]").text(description); $(".js-view-count[data-work-id=19608783]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608783; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608783']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608783]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608783,"title":"Aging and tissue plasminogen activator release","internal_url":"https://www.academia.edu/19608783/Aging_and_tissue_plasminogen_activator_release","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608782"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608782/Prolongation_of_bleeding_time_by_acute_hemolysis_in_rats_a_role_for_nitric_oxide"><img alt="Research paper thumbnail of Prolongation of bleeding time by acute hemolysis in rats: a role for nitric oxide" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608782/Prolongation_of_bleeding_time_by_acute_hemolysis_in_rats_a_role_for_nitric_oxide">Prolongation of bleeding time by acute hemolysis in rats: a role for nitric oxide</a></div><div class="wp-workCard_item"><span>The American journal of physiology</span><span>, 1997</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The present study was aimed at clarifying the interaction between red blood cell trauma and bleed...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The present study was aimed at clarifying the interaction between red blood cell trauma and bleeding observed in some clinical conditions. Acute hemolysis provoked by distilled water injection was followed by a significant prolongation of the &quot;template&quot; bleeding time in rats. Comparable effects were observed after injection of an isotonic lysate of washed red blood cells. N omega-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) formation from L-arginine, normalized bleeding time when given to rats before hemolysis induction. The occurrence of hemolysis decreased ex vivo platelet adhesion to collagen without affecting platelet aggregation and induced a transient drop in blood pressure, the latter occurring during the first minute after injection. L-NAME pretreatment increased ex vivo platelet adhesion but did not affect either platelet aggregation or fall in blood pressure. All the effects of L-NAME were blunted by treating the animals with the NO p...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608782"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608782"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608782; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608782]").text(description); $(".js-view-count[data-work-id=19608782]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608782; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608782']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608782]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608782,"title":"Prolongation of bleeding time by acute hemolysis in rats: a role for nitric oxide","internal_url":"https://www.academia.edu/19608782/Prolongation_of_bleeding_time_by_acute_hemolysis_in_rats_a_role_for_nitric_oxide","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608781"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608781/Cathepsin_G_induced_release_of_PAI_1_in_the_culture_medium_of_endothelial_cells_a_new_thrombogenic_role_for_polymorphonuclear_leukocytes"><img alt="Research paper thumbnail of Cathepsin G--induced release of PAI-1 in the culture medium of endothelial cells: a new thrombogenic role for polymorphonuclear leukocytes?" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608781/Cathepsin_G_induced_release_of_PAI_1_in_the_culture_medium_of_endothelial_cells_a_new_thrombogenic_role_for_polymorphonuclear_leukocytes">Cathepsin G--induced release of PAI-1 in the culture medium of endothelial cells: a new thrombogenic role for polymorphonuclear leukocytes?</a></div><div class="wp-workCard_item"><span>The Journal of laboratory and clinical medicine</span><span>, 1993</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Activated polymorphonuclear leukocytes (PMNs) may affect the integrity of blood vessels by endoth...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Activated polymorphonuclear leukocytes (PMNs) may affect the integrity of blood vessels by endothelial cell injury. We investigated the effects of cathepsin G purified from human neutrophils on the fibrinolytic potential of cultured human umbilical vein endothelial cells (HUVECs). Cathepsin G (5 and 10 micrograms/ml) induced marked intercellular gap formation after 1 hour of treatment, whereas 1 microgram/ml did not, even after 6 hours incubation. In contrast, plasminogen activator inhibitor-1 (PAI-1) antigen levels, measured by a double antibody enzyme-linked immunosorbent assay, were significantly increased in culture media (CM) on cathepsin G (1 microgram/ml) treatment after 15 minutes (5.1 +/- 1.2 ng/ml vs 2.6 +/- 0.6 ng/ml for controls, p &lt; 0.01) and 6 hours of incubation (69.6 +/- 17.5 ng/ml vs 40.0 +/- 9.0 ng/ml for controls, p &lt; 0.01). Likewise, PAI activity, measured by reverse fibrin autography, increased on cell treatment with cathepsin G. Preincubation of cathepsin...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608781"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608781"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608781; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608781]").text(description); $(".js-view-count[data-work-id=19608781]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608781; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608781']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608781]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608781,"title":"Cathepsin G--induced release of PAI-1 in the culture medium of endothelial cells: a new thrombogenic role for polymorphonuclear leukocytes?","internal_url":"https://www.academia.edu/19608781/Cathepsin_G_induced_release_of_PAI_1_in_the_culture_medium_of_endothelial_cells_a_new_thrombogenic_role_for_polymorphonuclear_leukocytes","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608780"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608780/The_Mediterranean_diet_the_reasons_for_a_success"><img alt="Research paper thumbnail of The Mediterranean diet: the reasons for a success" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608780/The_Mediterranean_diet_the_reasons_for_a_success">The Mediterranean diet: the reasons for a success</a></div><div class="wp-workCard_item"><span>Thrombosis research</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">There is a substantial body of evidence linking Mediterranean Diet to cardiovascular risk reducti...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">There is a substantial body of evidence linking Mediterranean Diet to cardiovascular risk reduction and prevention of the major chronic diseases. Nevertheless Mediterranean societies are rapidly withdrawing from this eating pattern orienting their food choices toward products typical of the Western diet pattern, which is rich in refined grains, animal fats, sugars, processed meat but are quite poor in legumes, cereals, fruits and vegetables. The reasons people keep on shifting from healthy to unhealthy dietary habits remain open to several interpretations. Social changes appear to have consistently contributed to radical reversal in dietary habits in European Mediterranean societies even though developing Countries are somewhat turning into westernized diets as well. Among possible causes, increasing prices of some of the major food items of Mediterranean pyramid seem to have led people to give up this eating pattern in favor of less expensive products which allow to save money but ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608780"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608780"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608780; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608780]").text(description); $(".js-view-count[data-work-id=19608780]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608780; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608780']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608780]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608780,"title":"The Mediterranean diet: the reasons for a success","internal_url":"https://www.academia.edu/19608780/The_Mediterranean_diet_the_reasons_for_a_success","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608779"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19608779/Analysis_of_675_4_g_5_G_SERPINE1_and_C_159T_CD14_polymorphisms_in_house_dust_mite_allergic_asthma_patients"><img alt="Research paper thumbnail of Analysis of -675 4 g/5 G SERPINE1 and C-159T CD14 polymorphisms in house dust mite-allergic asthma patients" class="work-thumbnail" src="https://attachments.academia-assets.com/42072736/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19608779/Analysis_of_675_4_g_5_G_SERPINE1_and_C_159T_CD14_polymorphisms_in_house_dust_mite_allergic_asthma_patients">Analysis of -675 4 g/5 G SERPINE1 and C-159T CD14 polymorphisms in house dust mite-allergic asthma patients</a></div><div class="wp-workCard_item"><span>Journal of investigational allergology & clinical immunology</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Experimental studies indicate that endogenous plasminogen activator inhibitor-1 (PAI-1, encoded b...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Experimental studies indicate that endogenous plasminogen activator inhibitor-1 (PAI-1, encoded by the gene SERPINE1) modulates the immune response to lipopolysaccharide (LPS). On the other hand, LPS induces PAI-1 secretion. Activation of individual cells by LPS is facilitated by CD14. The single nucleotide polymorphisms -675 4G/5G in SERPINE1 and C-159T in CD14 are major determinants of PAI-1 and CD14 expression, respectively. To evaluate the frequency of the -675 4G/5G SERPINE1 and C-159T CD14 polymorphisms in house dust mite (HDM) allergic asthma patients. The polymorphisms were evaluated in unrelated inhabitants of northeastern Poland, including 372 HDM-allergic asthmatic patients and 160 healthy nonatopic control subjects using polymerase chain reaction. Both the C allele of CD14 and the 4G allele of SERPINE1 were more frequently encountered in HDM-allergic asthmatic patients than in healthy control individuals. When the 5G/5G-TT/CT genotype was considered as a nonrisk genotype...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="24aed632e6c6c470aee6272438381a79" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42072736,"asset_id":19608779,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42072736/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608779"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608779"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608779; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608779]").text(description); $(".js-view-count[data-work-id=19608779]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608779; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608779']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "24aed632e6c6c470aee6272438381a79" } } $('.js-work-strip[data-work-id=19608779]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608779,"title":"Analysis of -675 4 g/5 G SERPINE1 and C-159T CD14 polymorphisms in house dust mite-allergic asthma patients","internal_url":"https://www.academia.edu/19608779/Analysis_of_675_4_g_5_G_SERPINE1_and_C_159T_CD14_polymorphisms_in_house_dust_mite_allergic_asthma_patients","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[{"id":42072736,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42072736/thumbnails/1.jpg","file_name":"Analysis_of_-675_4G5G_SERPINE1_and_C-15920160204-9568-1lnv8vi.pdf","download_url":"https://www.academia.edu/attachments/42072736/download_file","bulk_download_file_name":"Analysis_of_675_4_g_5_G_SERPINE1_and_C_1.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42072736/Analysis_of_-675_4G5G_SERPINE1_and_C-15920160204-9568-1lnv8vi-libre.pdf?1454614178=\u0026response-content-disposition=attachment%3B+filename%3DAnalysis_of_675_4_g_5_G_SERPINE1_and_C_1.pdf\u0026Expires=1739725481\u0026Signature=fkiyMuhMu82TW~ufvIR1Bl~S943Sws0PwyEDDd-GDjXInj9L~pq5vz8vXGlNySmOYb8uo6FOGY2Qbr1ZfPIvNVru6KBtw2guqMw6Vmrxb23g3GmCDW2TW-7tXaXWqSDJN8i~-msj2sy85MARPF4BNIs8qgKjidn7OJIGApBvhYuFNuwQTFyWwqGlfp4AFnU6ApEzywzhYgL1Ia8QE3VPjocKXgBWrGnDD68prOzu9BS33BWSA1CxgIfGK98LzITO4sNuTW-dc35Zfz3wz~PmDEI0AjqR5Sz7xwWRBU8YcSpT~kDKaAt32hNY6XVmkbWV8e~GA5-JN~biiRp3glmCCA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608778"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19608778/The_E27_beta2_adrenergic_receptor_polymorphism_reduces_the_risk_of_myocardial_infarction_in_dyslipidemic_young_males"><img alt="Research paper thumbnail of The E27 beta2-adrenergic receptor polymorphism reduces the risk of myocardial infarction in dyslipidemic young males" class="work-thumbnail" src="https://attachments.academia-assets.com/42072738/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19608778/The_E27_beta2_adrenergic_receptor_polymorphism_reduces_the_risk_of_myocardial_infarction_in_dyslipidemic_young_males">The E27 beta2-adrenergic receptor polymorphism reduces the risk of myocardial infarction in dyslipidemic young males</a></div><div class="wp-workCard_item"><span>Thrombosis and haemostasis</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the present study we evaluated whether two polymorphisms of beta2-adrenergic receptors (beta2-...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the present study we evaluated whether two polymorphisms of beta2-adrenergic receptors (beta2-AR) gene (R16G and Q27E) could modify the risk of myocardial infarction (MI). Using a case-control design, we analyzed the data from 125 male patients who had experienced a first episode of MI before the age of 45 years and 108 male controls matched for age. The allele frequencies for R16G and Q27E were: G16=0.56 and E27=0.36 in patients with MI and G16=0.61 and E27=0.42 in the control group. There was a trend (not statistically significant) of decreasing MI risk according to E27 or G16 alleles. Combined effect between E27 allele and history of dyslipidemia has been observed. Whereas dyslipidemia conferred a relative risk of MI of 4.8 (P&lt;0.001) compared with normolipidemia in the entire study population, the relative risk increased to 9.0 (P&lt;0.001) in Q27 homozygotes with dyslipidemia, and decreased to 1.8 (P=0.36) in E27 homozygotes. Our results show that the E27 allele of the bet...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6223154c76739b49a66d42628d46bd60" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42072738,"asset_id":19608778,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42072738/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608778"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608778"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608778; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608778]").text(description); $(".js-view-count[data-work-id=19608778]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608778; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608778']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6223154c76739b49a66d42628d46bd60" } } $('.js-work-strip[data-work-id=19608778]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608778,"title":"The E27 beta2-adrenergic receptor polymorphism reduces the risk of myocardial infarction in dyslipidemic young males","internal_url":"https://www.academia.edu/19608778/The_E27_beta2_adrenergic_receptor_polymorphism_reduces_the_risk_of_myocardial_infarction_in_dyslipidemic_young_males","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[{"id":42072738,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42072738/thumbnails/1.jpg","file_name":"The_E27_beta2-adrenergic_receptor_polymo20160204-9573-1dzidno.pdf","download_url":"https://www.academia.edu/attachments/42072738/download_file","bulk_download_file_name":"The_E27_beta2_adrenergic_receptor_polymo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42072738/The_E27_beta2-adrenergic_receptor_polymo20160204-9573-1dzidno-libre.pdf?1454614177=\u0026response-content-disposition=attachment%3B+filename%3DThe_E27_beta2_adrenergic_receptor_polymo.pdf\u0026Expires=1739725481\u0026Signature=Q2z66nqNeu1bj2PI0BLgZzLbiX8FSMEUx~ddP58BTn75VtorF4u5mnXjnxJy0qDI2nLlr6xcX02WA5JRKO7fZvHlrCobXC95zmY11oPdnqmfMm9eyDhaxq0sDRhTPWW3xsNOFknPOQkNX~4q4rtbxrhJ3XWIsmQ1CCna-Ji2IWgjWlTFQuw2KGfqufbg2E2iOF2U3n6Q36-9G4~qZMzbH2cOHbgObZUFDRGN17uunEdtIIcNJ9bBtoHmJIC1MQMNldMx08YRZYWwxjjFgMktaZ3wFCAG-f5Xgt13LbLrXLGFT-8~FrmE7Gjpv59ZEa~a-QvJeZluowC0q4DxhIPwwQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608777"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608777/Risk_of_myocardial_infarction_in_carriers_of_mutations_in_the_hemochromatosis_associated_gene"><img alt="Research paper thumbnail of Risk of myocardial infarction in carriers of mutations in the hemochromatosis-associated gene" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608777/Risk_of_myocardial_infarction_in_carriers_of_mutations_in_the_hemochromatosis_associated_gene">Risk of myocardial infarction in carriers of mutations in the hemochromatosis-associated gene</a></div><div class="wp-workCard_item"><span>Thrombosis and haemostasis</span><span>, 2000</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608777"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608777"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608777; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608777]").text(description); $(".js-view-count[data-work-id=19608777]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608777; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608777']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608777]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608777,"title":"Risk of myocardial infarction in carriers of mutations in the hemochromatosis-associated gene","internal_url":"https://www.academia.edu/19608777/Risk_of_myocardial_infarction_in_carriers_of_mutations_in_the_hemochromatosis_associated_gene","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608776"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19608776/A_hypercoagulable_state_in_activated_protein_C_resistant_patients_with_ischemic_stroke"><img alt="Research paper thumbnail of A hypercoagulable state in activated protein C resistant patients with ischemic stroke" class="work-thumbnail" src="https://attachments.academia-assets.com/40730297/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19608776/A_hypercoagulable_state_in_activated_protein_C_resistant_patients_with_ischemic_stroke">A hypercoagulable state in activated protein C resistant patients with ischemic stroke</a></div><div class="wp-workCard_item"><span>International journal of clinical & laboratory research</span><span>, 1998</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8783b2bc5af9cbfd35445a93538c9584" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":40730297,"asset_id":19608776,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/40730297/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608776"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608776"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608776; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608775"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608775/Reduced_pulmonary_metastases_of_lewis_lung_carcinoma_in_hPAI_1_transgenic_mice"><img alt="Research paper thumbnail of Reduced pulmonary metastases of lewis lung carcinoma in hPAI-1 transgenic mice" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608775/Reduced_pulmonary_metastases_of_lewis_lung_carcinoma_in_hPAI_1_transgenic_mice">Reduced pulmonary metastases of lewis lung carcinoma in hPAI-1 transgenic mice</a></div><div class="wp-workCard_item"><span>Fibrinolysis</span><span>, 1994</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608775"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608775"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608775; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608775]").text(description); $(".js-view-count[data-work-id=19608775]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608775; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608775']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608775]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608775,"title":"Reduced pulmonary metastases of lewis lung carcinoma in hPAI-1 transgenic mice","internal_url":"https://www.academia.edu/19608775/Reduced_pulmonary_metastases_of_lewis_lung_carcinoma_in_hPAI_1_transgenic_mice","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608774"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608774/Prostacyclin_is_required_for_t_PA_release_after_venous_occlusion"><img alt="Research paper thumbnail of Prostacyclin is required for t-PA release after venous occlusion" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608774/Prostacyclin_is_required_for_t_PA_release_after_venous_occlusion">Prostacyclin is required for t-PA release after venous occlusion</a></div><div class="wp-workCard_item"><span>The American journal of physiology</span><span>, 1994</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The role of vascular cyclooxygenase pathway on tissue-type plasminogen activator (t-PA) release a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The role of vascular cyclooxygenase pathway on tissue-type plasminogen activator (t-PA) release after venous occlusion was studied in anesthetized rats. After the inferior vena cava was clamped for 30 min, fibrinolytic activity increased from 143.7 +/- 14.5 to 209.5 +/- 10.3 mm2 (mean +/- SE, P &lt; 0.002). This increase was prevented by aspirin at high (100 mg/kg i.v.) but not at low doses (1 mg/kg i.v.). Dazoxiben (10 mg/kg i.v.), an inhibitor of thromboxane synthase, was ineffective on the fibrinolytic response. Both the basal levels of 6-ketoprostaglandin F1 alpha and its increase after venous occlusion were suppressed by 100 mg/kg aspirin administration (from 0.64 +/- 0.2 to 0.05 +/- 0.002 ng/ml before occlusion, P &lt; 0.001; and from 1.08 +/- 0.2 to 0.06 +/- 0.002 ng/kg after occlusion, P &lt; 0.001), whereas they were both unaffected by aspirin at low doses (from 0.53 +/- 0.06 before to 1.20 +/- 0.08 ng/ml after stasis). Moreover, iloprost, a stable analogue of prostacyclin,...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608774"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608774"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608774; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608774]").text(description); $(".js-view-count[data-work-id=19608774]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608774; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608774']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608774]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608774,"title":"Prostacyclin is required for t-PA release after venous occlusion","internal_url":"https://www.academia.edu/19608774/Prostacyclin_is_required_for_t_PA_release_after_venous_occlusion","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608773"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608773/Enhanced_vascular_plasminogen_activator_t_PA_release_by_epinephrine_in_aged_rats"><img alt="Research paper thumbnail of Enhanced vascular plasminogen activator (t-PA) release by epinephrine in aged rats" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608773/Enhanced_vascular_plasminogen_activator_t_PA_release_by_epinephrine_in_aged_rats">Enhanced vascular plasminogen activator (t-PA) release by epinephrine in aged rats</a></div><div class="wp-workCard_item"><span>Thrombosis and haemostasis</span><span>, 1995</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Adrenergic stimulation induces an acute fibrinolytic response in the vascular wall and can play a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Adrenergic stimulation induces an acute fibrinolytic response in the vascular wall and can play an important role in limiting thrombus growth. The incidence of thrombotic disease increases with age. As many adrenergic functions are affected by aging, the vascular response to adrenergic stimulation was studied in young (3 +/- 1 months) and aged (18 +/- 3 months) rats, using an experimental model of vascular perfusion. Five min epinephrine (EPI) infusion (0.15-25 microM) induced a dose-dependent increase in tissue-type plasminogen activator (t-PA) release and in perfusion pressure, in both young and aged rats. In the latter, however, the basal activity of t-PA was significantly higher than in young animals (0.22 +/- 0.02 vs 0.13 +/- 0.01 U/ml; means +/- SE; p &lt; 0.01, n = 40) and EPI infusion induced a significantly higher increase in t-PA activity (0.78 +/- 0.06 vs 0.47 +/- 0.08 U/ml, p &lt; 0.01, for 6.25 microM EPI). The response was characterized by a delayed onset. In contrast,...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608773"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608773"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608773; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608773]").text(description); $(".js-view-count[data-work-id=19608773]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608773; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608773']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608773]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608773,"title":"Enhanced vascular plasminogen activator (t-PA) release by epinephrine in aged rats","internal_url":"https://www.academia.edu/19608773/Enhanced_vascular_plasminogen_activator_t_PA_release_by_epinephrine_in_aged_rats","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608772"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19608772/T_wave_axis_deviation_metabolic_syndrome_and_cardiovascular_risk_results_from_the_MOLI_SANI_study"><img alt="Research paper thumbnail of T-wave axis deviation, metabolic syndrome and cardiovascular risk: results from the MOLI-SANI study" class="work-thumbnail" src="https://attachments.academia-assets.com/42072761/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19608772/T_wave_axis_deviation_metabolic_syndrome_and_cardiovascular_risk_results_from_the_MOLI_SANI_study">T-wave axis deviation, metabolic syndrome and cardiovascular risk: results from the MOLI-SANI study</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Early recognition of patients at increased cardiovascular risk is a major challenge. The surface ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Early recognition of patients at increased cardiovascular risk is a major challenge. The surface electrocardiogram provides a useful platform and it has been used to propose several indexes. T wave axis abnormality is associated with an increased risk of cardiovascular mortality, independently of other risk factors and can be associated with the presence of the metabolic syndrome (MetS). We assessed the prevalence of T axis abnormalities and its relationship with MetS and its components in a large population of Italian adults. Data concerning 11,143 women (54 ± 11 years) and 9742 men (55 ± 11 years) randomly recruited from a general population (Moli-sani cohort) were analyzed. After excluding subjects with incomplete data and with history of cardiac disease or left ventricular hypertrophy, T-wave axis was normal in 74.5% of men and 80.9% of women, borderline in 23.6% and 17.3% and abnormal in 1.9% and 1.8%. In subjects with MetS, the prevalence of borderline or abnormal T-wave axis deviation was higher than in subjects without MetS (in men: 26.6% vs. 22.1% and 2.5% vs. 1.7%; in women: 25% vs. 15% and 2.4% vs. 1.6%, respectively for borderline and abnormal levels, p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.0001). Each component of MetS increased the odds of having borderline or abnormal T-wave axis deviation by 1.21 in men and 1.31 in women. T wave axis deviation is associated with MetS and its individual components. These findings confirm previous reported results, expanding them to a large and representative sample of European population of Caucasian ethnicity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eda9941b6228b5804ea252e8c2d3edf2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42072761,"asset_id":19608772,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42072761/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608772"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608772"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608772; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608772]").text(description); $(".js-view-count[data-work-id=19608772]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608772; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608772']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "eda9941b6228b5804ea252e8c2d3edf2" } } $('.js-work-strip[data-work-id=19608772]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608772,"title":"T-wave axis deviation, metabolic syndrome and cardiovascular risk: results from the MOLI-SANI study","internal_url":"https://www.academia.edu/19608772/T_wave_axis_deviation_metabolic_syndrome_and_cardiovascular_risk_results_from_the_MOLI_SANI_study","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[{"id":42072761,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42072761/thumbnails/1.jpg","file_name":"j.jelectrocard.2012.07.019.pdf20160204-22322-ozbkc9","download_url":"https://www.academia.edu/attachments/42072761/download_file","bulk_download_file_name":"T_wave_axis_deviation_metabolic_syndrome.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42072761/j.jelectrocard.2012.07.019-libre.pdf20160204-22322-ozbkc9?1454614175=\u0026response-content-disposition=attachment%3B+filename%3DT_wave_axis_deviation_metabolic_syndrome.pdf\u0026Expires=1739725481\u0026Signature=QCHgyf0YH8el1A9oDwPwGZ6U1Isf4apYKmUs5ziYFMO2MiP9iK1ZxDhfGuctF0qscwyBUsqrPQnbKng-zNsjgfHg8OCJsg3fGxLbGbe9s3QyeaIK6y~vPTnTUdEe2J19iC79ShlmHye6SEZWcDqb6gplSYqGuxtbLhICmn8P~PUsAqGNKohTrDh9f10fqHdalENoZ6CQLUh8IsVt6r9BfBhsEg9Y9NzaLahg60e~eK3ZjW4vELfBtxdn3YeOWhUCVI~TGhi3az5zAPu0YVSYKcq4Z0z93hrgX3hXMLUPev6S2uQEMairuZz1F2Mp3XLeR2aMFMyOhH2Dv2rd7lIoJw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608771"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19608771/The_Moli_sani_project_computerized_ECG_database_in_a_population_based_cohort_study"><img alt="Research paper thumbnail of The Moli-sani project: computerized ECG database in a population-based cohort study" class="work-thumbnail" src="https://attachments.academia-assets.com/40730296/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19608771/The_Moli_sani_project_computerized_ECG_database_in_a_population_based_cohort_study">The Moli-sani project: computerized ECG database in a population-based cohort study</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Computerized electrocardiogram (ECG) acquisition and interpretation may be extremely useful in ha...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Computerized electrocardiogram (ECG) acquisition and interpretation may be extremely useful in handling analysis of data from large cohort studies and exploit research on the use of ECG data as prognostic markers for cardiovascular disease. The Moli-sani project (<a href="http://www.moli-sani.org" rel="nofollow">http://www.moli-sani.org</a>) is a population-based cohort study aiming at evaluating the risk factors linked to chronic-degenerative disease with particular regard to cardiovascular disease and cancer and intermediate metabolic phenotypes such as hypertension, diabetes, dyslipidemia, obesity, and metabolic syndrome. Between March 2005 and April 2010, 24 325 people aged 35 years or older, living in the Molise region (Italy), were randomly recruited. A follow-up based on linkage with hospital discharge records and mortality regional registry and reexamination of the cohort is ongoing and will be repeated at prefixed times. Each subject was administered questionnaires on personal and medical history, food consumption, quality of life (FS36), and psychometry. Plasma serum, cellular pellet, and urinary spots were stored in liquid nitrogen. Subjects were measured blood pressure, weight, height, and waist and hip circumferences, and underwent spirometry to evaluate pulmonary diffusion capacity, gas diffusion, and pulmonary volumes. Standard 12-lead resting ECG was performed by a Cardiette ar2100-view electrocardiograph and tracings stored in digital standard communication protocol format for subsequent analysis. The digital ECG database of the Moli-sani project is currently being used to assess the association between physiologic variables and pathophyiosiologic conditions and parameters derived from the ECG signal. This computerized ECG database represents a unique opportunity to identify and assess prognostic factors associated with cardiovascular and metabolic diseases.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cb152efac64bfff67bf56a4169169e82" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":40730296,"asset_id":19608771,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/40730296/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608771"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608771"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608771; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608771]").text(description); $(".js-view-count[data-work-id=19608771]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608771; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608771']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "cb152efac64bfff67bf56a4169169e82" } } $('.js-work-strip[data-work-id=19608771]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608771,"title":"The Moli-sani project: computerized ECG database in a population-based cohort study","internal_url":"https://www.academia.edu/19608771/The_Moli_sani_project_computerized_ECG_database_in_a_population_based_cohort_study","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[{"id":40730296,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/40730296/thumbnails/1.jpg","file_name":"j.jelectrocard.2012.07.008.pdf20151211-17754-10jn2ob","download_url":"https://www.academia.edu/attachments/40730296/download_file","bulk_download_file_name":"The_Moli_sani_project_computerized_ECG_d.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/40730296/j.jelectrocard.2012.07.008-libre.pdf20151211-17754-10jn2ob?1449848836=\u0026response-content-disposition=attachment%3B+filename%3DThe_Moli_sani_project_computerized_ECG_d.pdf\u0026Expires=1739725481\u0026Signature=FWqBsd-cwmRbz6I~D15KZwtWS3Yd9pL8yE4WoQRDRjVcc6oF55Tid0rRIeZBskqs24JppeKR1BfQkoyTuEqE6FLl3JZs2VqW9gUUn5SvGpKYdapAnZfct9s1DI7njwv8bJe1x1GT66baAPBRg7MAq7Rp6rEPb8vGPmZUKJDm2gUlFFyAnfp-cYnqXrE3eWdE~aiWF-Ys1yCvBrpqWi7UA6CjDgwfCdC8zCS1Mc39CkSE8~7XCdrVL0J9RVubku9smv8nT2eb2aWOGBnfttVBig~XaZA062-dmUhLyPHEmhuldDld3GzfRLq7idUdgTd7bohxqdLISBj8wM4GDCm3TA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608770"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19608770/Prevalence_and_cardiovascular_risk_profile_of_chronic_kidney_disease_in_Italy_results_of_the_2008_12_National_Health_Examination_Survey"><img alt="Research paper thumbnail of Prevalence and cardiovascular risk profile of chronic kidney disease in Italy: results of the 2008-12 National Health Examination Survey" class="work-thumbnail" src="https://attachments.academia-assets.com/42072747/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19608770/Prevalence_and_cardiovascular_risk_profile_of_chronic_kidney_disease_in_Italy_results_of_the_2008_12_National_Health_Examination_Survey">Prevalence and cardiovascular risk profile of chronic kidney disease in Italy: results of the 2008-12 National Health Examination Survey</a></div><div class="wp-workCard_item"><span>Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association</span><span>, Jan 18, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">National surveys in countries outside Europe have reported a high prevalence (11-13%) of chronic ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">National surveys in countries outside Europe have reported a high prevalence (11-13%) of chronic kidney disease (CKD). Studies in Europe have provided a variable prevalence likely due to differences in study design, including age and extent of geographic areas, equation used to evaluate estimated glomerular filtration rate (eGFR) and CKD stages examined. The 2008-12 National Health Examination Survey in Italy randomly extracted samples from the general population aged 35-79 years, stratified by age and gender, from the resident list of each Italian region (440 persons/1.5 million of residents). We estimated the prevalence of CKD by means of urinary albumin : creatinine ratio and eGFR (CKD-EPI equation-enzymatic assay of serum creatinine). Cardiovascular (CV) risk profile was also evaluated. Three thousand eight hundred and forty-eight men and 3704 women were examined. In the whole population, mean age was 57 ± 12 and 56 ± 12 years in men and women, respectively; hypertension was pre...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="001be4f8a79db581372e909e5e173fa9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42072747,"asset_id":19608770,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42072747/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608770"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608770"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608770; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608770]").text(description); $(".js-view-count[data-work-id=19608770]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608770; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608770']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608769"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608769/Analysis_of_gene_environment_interaction_in_coronary_heart_disease_fibrinogen_polymorphisms_as_an_example"><img alt="Research paper thumbnail of Analysis of gene-environment interaction in coronary heart disease: fibrinogen polymorphisms as an example" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608769/Analysis_of_gene_environment_interaction_in_coronary_heart_disease_fibrinogen_polymorphisms_as_an_example">Analysis of gene-environment interaction in coronary heart disease: fibrinogen polymorphisms as an example</a></div><div class="wp-workCard_item"><span>Italian heart journal : official journal of the Italian Federation of Cardiology</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Several epidemiological studies have shown that an increase in fibrinogen levels is associated wi...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Several epidemiological studies have shown that an increase in fibrinogen levels is associated with the risk of cardiovascular disease. Recently, it has been demonstrated that the levels of fibrinogen can be genetically determined. Overall the studies show a strong association between two polymorphisms of the fibrinogen beta-chain gene and fibrinogen plasma concentration. Few studies have, in contrast, found an association between such polymorphisms and the risk of ischemic vascular disease. Rather than directly affecting the levels of proteins or the risk of disease, polymorphisms can amplify the effect of environmental or intermediate conditions on the final phenotype. The genetic control of fibrinogen has to be considered together with environmental factors: fibrinogen genotypes may interact with cigarette smoking, gender, physical activity, use of drugs and infections in determining the increase in fibrinogen levels and perhaps the risk of ischemic heart disease. Three examples ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608769"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608769"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608769; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608769]").text(description); $(".js-view-count[data-work-id=19608769]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 19608769; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='19608769']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608769]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608769,"title":"Analysis of gene-environment interaction in coronary heart disease: fibrinogen polymorphisms as an example","internal_url":"https://www.academia.edu/19608769/Analysis_of_gene_environment_interaction_in_coronary_heart_disease_fibrinogen_polymorphisms_as_an_example","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608768"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/19608768/Regular_consumption_of_dark_chocolate_is_associated_with_low_serum_concentrations_of_C_reactive_protein_in_a_healthy_Italian_population"><img alt="Research paper thumbnail of Regular consumption of dark chocolate is associated with low serum concentrations of C-reactive protein in a healthy Italian population" class="work-thumbnail" src="https://attachments.academia-assets.com/42072744/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/19608768/Regular_consumption_of_dark_chocolate_is_associated_with_low_serum_concentrations_of_C_reactive_protein_in_a_healthy_Italian_population">Regular consumption of dark chocolate is associated with low serum concentrations of C-reactive protein in a healthy Italian population</a></div><div class="wp-workCard_item"><span>The Journal of nutrition</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dark chocolate contains high concentrations of flavonoids and may have antiinflammatory propertie...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dark chocolate contains high concentrations of flavonoids and may have antiinflammatory properties. We evaluated the association of dark chocolate intake with serum C-reactive protein (CRP). The Moli-sani Project is an ongoing cohort study of men and women aged &gt;/=35 y randomly recruited from the general population. By July 2007, 10,994 subjects had been enrolled. Of 4849 subjects apparently free of any chronic disease, 1317 subjects who declared having eaten any chocolate during the past year (mean age 53 +/- 12 y; 51% men) and 824 subjects who ate chocolate regularly in the form of dark chocolate only (50 +/- 10 y; 55% men) were selected. High sensitivity-CRP was measured by an immunoturbidimetric method. The European Prospective Investigation into Cancer and Nutrition FFQ was used to evaluate nutritional intake. After adjustment for age, sex, social status, physical activity, systolic blood pressure, BMI, waist:hip ratio, food groups, and total energy intake, dark chocolate co...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5b6222ab0bf1691ef383a7e88ae394c4" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":42072744,"asset_id":19608768,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/42072744/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608768"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608768"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608768; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5b6222ab0bf1691ef383a7e88ae394c4" } } $('.js-work-strip[data-work-id=19608768]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608768,"title":"Regular consumption of dark chocolate is associated with low serum concentrations of C-reactive protein in a healthy Italian population","internal_url":"https://www.academia.edu/19608768/Regular_consumption_of_dark_chocolate_is_associated_with_low_serum_concentrations_of_C_reactive_protein_in_a_healthy_Italian_population","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[{"id":42072744,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/42072744/thumbnails/1.jpg","file_name":"Regular_consumption_of_dark_chocolate_is20160204-9573-1e2aqws.pdf","download_url":"https://www.academia.edu/attachments/42072744/download_file","bulk_download_file_name":"Regular_consumption_of_dark_chocolate_is.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/42072744/Regular_consumption_of_dark_chocolate_is20160204-9573-1e2aqws-libre.pdf?1454614177=\u0026response-content-disposition=attachment%3B+filename%3DRegular_consumption_of_dark_chocolate_is.pdf\u0026Expires=1739725481\u0026Signature=FofVCozBKQtodnj4~bjOaerVXSqoONyo-OoD6mleKo04eaDYjaI5Sg1ba16uRSCFvtzfcXFQzA6FlSjDbLevPAh1uOjm537GePIWtqAvhacBHJyhveK2F8lmiBhRRFc4ylwM83aGh4QAJuBIkcqerprguWDYgdx5tYn48x1z0b3Ewn0vGNdwk~zxuwUgnnCBvemROg3WbO94A399z5hYZ3R0f4HBRigxKhUvrjaJC7JhqWY7uS8-kWvEEJenKAYza-uYl6h7C5Isek4EEyMLAfAoP60i4SJy~SU08Jlq6oi147dkLx7Aqd1LW6en2A38uns3dgEH9cvUhASEOFvGfA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="19608767"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/19608767/PFA_100_closure_time_to_predict_cardiovascular_events_in_aspirin_treated_cardiovascular_patients_A_meta_analysis_of_19_studies_comprising_3_003_patients"><img alt="Research paper thumbnail of PFA-100 closure time to predict cardiovascular events in aspirin-treated cardiovascular patients: A meta-analysis of 19 studies comprising 3,003 patients" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/19608767/PFA_100_closure_time_to_predict_cardiovascular_events_in_aspirin_treated_cardiovascular_patients_A_meta_analysis_of_19_studies_comprising_3_003_patients">PFA-100 closure time to predict cardiovascular events in aspirin-treated cardiovascular patients: A meta-analysis of 19 studies comprising 3,003 patients</a></div><div class="wp-workCard_item"><span>Thrombosis and Haemostasis</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">RefDoc Bienvenue - Welcome. Refdoc est un service / is powered by. ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="19608767"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="19608767"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 19608767; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=19608767]").text(description); $(".js-view-count[data-work-id=19608767]").attr('title', description).tooltip(); 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=19608767]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":19608767,"title":"PFA-100 closure time to predict cardiovascular events in aspirin-treated cardiovascular patients: A meta-analysis of 19 studies comprising 3,003 patients","internal_url":"https://www.academia.edu/19608767/PFA_100_closure_time_to_predict_cardiovascular_events_in_aspirin_treated_cardiovascular_patients_A_meta_analysis_of_19_studies_comprising_3_003_patients","owner_id":40026775,"coauthors_can_edit":true,"owner":{"id":40026775,"first_name":"Licia","middle_initials":null,"last_name":"Iacoviello","page_name":"LIacoviello","domain_name":"independent","created_at":"2015-12-11T07:41:54.883-08:00","display_name":"Licia Iacoviello","url":"https://independent.academia.edu/LIacoviello"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); 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