Resolvin E1 synthesis | Genesis Drug Discovery & Development

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<li class="info-nav_link _active"> <a href="https://www.gd3services.com/divisions/chemistry/case-studies/resolvin-e1-synthesis/">Resolvin E1 synthesis</a> </li> </ul> <button class="info-nav_btn _right"></button> </div> </section> <div class="cta_wrapper"> <div class="cta"> <a href="https://www.gd3services.com/contact/" class="cta_btn"> <img class="cta_img" src="https://www.genesisglobalgrp.com/mods/cros/images/callout-img.png"> <div class="cta_main"> <div class="cta_text">Contact our Experts</div> </div> <div class="cta_dec"> <span></span> </div> </a> </div> </div> <section class="info overview _case"> <div class="overview_body"> <div class="overview_col"> <h1 class="info_title">Synthesis of Resolvin E1</h1> <p class="info_text">Resolvins, protectins and maresins are exquisitely potent cell signaling molecules derived from the omega-3-fatty acids eicosapentaenoic (EPA) and docosahexaenoic acid (DHA). These oxidative metabolites like Resolvin E1 (Figure 1) are synthesized on-demand via lipoxygenase and cyclooxygenase in tissues as a protective response to acute inflammatory insults. They play a key role in restoring homeostasis by limiting neutrophil tissue infiltration, counter regulating production of chemokines and cytokines, and stimulating M2 macrophage polarization<sup>1</sup>. As critical regulators on inflammatory response, SPMs have tremendous potential in numerous diseases including asthma<sup>2</sup>, rheumatoid arthritis<sup>3</sup>, lupus<sup>4</sup>, atherosclerosis<sup>5</sup>, psoriasis<sup>6</sup>, heart ischemia<sup>7</sup> and bacterial infections<sup>8</sup>.</p> </div> </div> <div class="overview_body"> <div class="overview_col"> <p class="info_text">Despite the importance of these bioactive molecules, research has been limited by compound availability. Current synthetic methods typically require more than twenty steps and are plagued with reactions that give mixtures of isomers and require tedious purifications. Chemists at NEDP have already completed the total synthesis of several SPMs on gram scale and are now optimizing them for large scale production. The material generated from these proprietary processes will be used to support clinical development of several drug products where SPMs are the API (Active pharmaceutical Ingredient).</p> <div class="info_references"> <h4>References</h4> <ol class="reference_list"> <li class="reference_list-item">Ohira, T., et al. Resolvin E1 Receptor Activation Signals Phosphorylation and Phagocytosis. <em>Journal of Biological Chemistry</em>, <strong>2010</strong>, 285, 3451-3461.</li> <li class="reference_list-item">Levy, B. D., et al. Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4. <em>Nat. Med.</em> <strong>2002</strong>, 8, 1018-1023.</li> <li class="reference_list-item">Arnardottir, H., et al. Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation. <em>Journal of Immunology</em> <strong>2016</strong>, 197, 2362-2368.</li> <li class="reference_list-item">Luca N. et al. Role of the Specialized Proresolving Mediator Resolvin D1 in Systemic Lupus Erythematosus: Preliminary Results, <em>Journal of Immunology Research</em>, <strong>2018</strong>, Article ID 5264195, 6 pages.</li> <li class="reference_list-item">Viola, J. et al. Resolving lipid mediators Maresin 1 and Resolvin D2 prevent atheroprogression in mice. <em>Circulation Research</em> <strong>2016</strong>, 119, 1030-1038.</li> <li class="reference_list-item">Sawada, Yu et al. Resolvin E1 attenuates murine psoriatic dermatitis. Scientific Reports <strong>2018</strong>.</li> <li class="reference_list-item">Keyes, K, T. et al. Resolvin E1 protects the rat heart against reperfusion injury. <em>Am. J. Physiol. Heart. Circ. Physiol</em>. <strong>2010</strong>, 299, 53-164.</li> <li class="reference_list-item">Chiang, N. et al. Novel Resolvin D2 receptor axis in infectious inflammation. <em>J. Immunol </em><strong>2017</strong>, 198, 842-851.</li> </ol> </div> </div> </div> </section> </div> </section> </main> <div id="modal">  <div id="optin-modal" class="modal_overlay"> <div class="modal _optin"> <span class="modal_icon"></span> <p class="modal_text">Before you download, please fill out some info so we can discuss our services with you</p> <div class="modal_body"> <form class="form specific" data-sth="downloads"> <div class="form_msg"> <p class="status">Thank you for your message!</p> </div> <div class="field required"> <input placeholder="Optional" class="if" type="text" name="d_name" required /> <label for="last-name">Name</label> </div> <div class="field required"> <input placeholder="Optional" class="if" type="email" name="d_email" required /> <label for="email">Email</label> </div> <div class="field"> <input placeholder="Optional" class="if" type="number" name="d_phone" /> <label for="phone">Phone</label> </div> <input type="hidden" name="link"> <input type="hidden" name="key_code" value="664852949223f8e624a7ae790b581be7"> <input type="hidden" class="timer" name="timer" value=""> <label style="display: block;height:0;"> <input type="text" name="catch" style="height: 100%; border:0; padding:0;"> </label> <div class="modal_row"> <button id="modal-close" type="button" class="btn">Cancel</button> <div> <a href="" class="btn _submit">Skip</a> <button type="submit" class="btn _submit">Continue</button> </div> </div> </form> </div> </div> </div> </div> <footer class="footer"> <div class="footer_bg in_view_check"> <div class="footer_content"> <div class="footer_container container"> <div class="footer_info"> <div class="footer_info_wrap"> <img class="footer_info_img" alt="Icon Map" src="https://www.genesisglobalgrp.com/mods/cros/images/icon-map.svg" /> </div> <span class="footer_info_text">2439 Kuser Road<br>Hamilton, NJ 08690</span> </div> <div class="footer_info"> <div class="footer_info_wrap"> <img class="footer_info_img" alt="Icon Phone" src="https://www.genesisglobalgrp.com/mods/cros/images/icon-phone.svg" /> </div> <span class="footer_info_text _strong"> 609-528-6850<br> </span> </div> <a class="footer_info" href="https://www.linkedin.com/company/gd3services"> <div class="footer_info_wrap"> <img class="footer_info_img _lin" alt="LinkedIn Logo" src="https://www.genesisglobalgrp.com/mods/cros/images/logo-linkedin.png" /> </div> <span class="footer_info_text _strong">Our LinkedIn</span> </a> </div> </div> </div> <div class="subfooter in_view_check"> <div class="subfooter_content container"> <div class="subfooter_links"> <a class="subfooter_text" href="https://www.gd3services.com/terms/">Terms of Use</a> <a class="subfooter_text" href="https://www.gd3services.com/privacy/">Privacy Policy</a> </div> <p class="subfooter_text">©2024 Genesis Drug Discovery & Development, All Rights Reserved.</p> </div> </div> </footer> </body> </html>

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