Cancer Diagnostics

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It is a critical field in medical diagnostics as it helps in identifying the cellular organization and structure of tissues, which is essential in diagnosing various diseases, including <a href="https://histology.blog/about/index/cancer" title="cancer" target="_blank">cancer</a>.</div><div><a href="https://histology.blog/knowledgebase/how-is-cancer-diagnosed-using-histology" title="How is Cancer Diagnosed Using Histology?"><h3>How is Cancer Diagnosed Using Histology?</h3></a>Cancer diagnosis in histology involves several steps. Initially, a biopsy is performed to obtain a tissue sample from a suspicious lesion. This sample is then fixed, usually in formalin, and embedded in paraffin. Thin sections of the tissue are cut using a microtome, mounted on slides, and stained with special dyes to highlight cellular structures. The slides are then examined under a microscope by a pathologist to identify any abnormal cells that may indicate cancer.</div><div><a href="https://histology.blog/knowledgebase/what-types-of-staining-techniques-are-used" title="What Types of Staining Techniques are Used?"><h3>What Types of Staining Techniques are Used?</h3></a>Various <a href="https://histology.blog/about/index/staining-techniques" title="staining techniques" target="_blank">staining techniques</a> are employed in histology to differentiate cellular components. The most common stain is Hematoxylin and Eosin (H&E), which provides a general overview of tissue structure and cellular detail. Other specialized stains include Immunohistochemistry (IHC), which uses antibodies to detect specific proteins, and in situ hybridization (ISH), which identifies specific DNA or RNA sequences within the tissue.</div><div><a href="https://histology.blog/knowledgebase/what-is-immunohistochemistry-ihc" title="What is Immunohistochemistry (IHC)?"><h3>What is Immunohistochemistry (IHC)?</h3></a><a href="https://histology.blog/about/index/immunohistochemistry" title="Immunohistochemistry" target="_blank">Immunohistochemistry</a> is a powerful technique used in histology for cancer diagnostics. It involves the use of antibodies that bind to specific antigens in the tissue. These antigen-antibody complexes are then visualized using a chromogenic or fluorescent label. IHC helps in identifying specific cancer markers, aiding in both the diagnosis and classification of cancer. For instance, the presence of HER2 protein can indicate breast cancer, while PSA is a marker for prostate cancer.</div><div><a href="https://histology.blog/knowledgebase/what-role-does-molecular-pathology-play" title="What Role Does Molecular Pathology Play?"><h3>What Role Does Molecular Pathology Play?</h3></a>Molecular pathology combines histological techniques with molecular biology to provide more precise cancer diagnostics. Techniques like Polymerase Chain Reaction (PCR) and Next-Generation Sequencing (NGS) can be used to detect genetic mutations, translocations, and other molecular changes associated with cancer. This information can be crucial for targeted therapies and personalized medicine.</div><div><a href="https://histology.blog/knowledgebase/how-important-is-the-role-of-the-pathologist" title="How Important is the Role of the Pathologist?"><h3>How Important is the Role of the Pathologist?</h3></a>The pathologist plays a vital role in cancer diagnostics. Their expertise in interpreting histological slides is critical in determining the presence and type of cancer. They examine the morphology of cells, the architecture of tissues, and use various staining techniques to reach a diagnosis. The pathologist鈥檚 report is essential for guiding treatment decisions and predicting patient outcomes.</div><div><a href="https://histology.blog/knowledgebase/what-are-the-limitations-of-histology-in-cancer-diagnostics" title="What are the Limitations of Histology in Cancer Diagnostics?"><h3>What are the Limitations of Histology in Cancer Diagnostics?</h3></a>While histology is a powerful tool, it does have limitations. The quality of the biopsy sample and the preparation process can affect the accuracy of the diagnosis. Additionally, some cancers may not present clear histological features, making diagnosis challenging. In such cases, supplementary techniques like molecular pathology or advanced imaging may be required.</div><div><a href="https://histology.blog/knowledgebase/how-has-technology-advanced-cancer-diagnostics-in-histology" title="How Has Technology Advanced Cancer Diagnostics in Histology?"><h3>How Has Technology Advanced Cancer Diagnostics in Histology?</h3></a>Advancements in technology have significantly improved cancer diagnostics in histology. Digital pathology, which involves scanning histological slides to create high-resolution digital images, allows for better storage, sharing, and analysis of tissue samples. Artificial intelligence (AI) and machine learning are also being integrated to assist pathologists in identifying cancerous changes more accurately and efficiently.</div><div><a href="https://histology.blog/knowledgebase/what-is-the-future-of-cancer-diagnostics-in-histology" title="What is the Future of Cancer Diagnostics in Histology?"><h3>What is the Future of Cancer Diagnostics in Histology?</h3></a>The future of cancer diagnostics in histology looks promising with ongoing research and technological innovations. The integration of digital pathology, AI, and molecular techniques is expected to enhance diagnostic accuracy and enable personalized treatment approaches. Moreover, the development of new biomarkers and targeted therapies will continue to advance the field, improving patient outcomes.</div></div> </div> <div id="recent_papers"> <br><hr /><br><h2 class="heading1">Relevant Publications</h2> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38944939" target='_blank' title="A self-immobilizing near-infrared fluorogenic probe for in vivo imaging of fibroblast activation protein-伪.">A self-immobilizing near-infrared fluorogenic probe for in vivo imaging of fibroblast activation protein-伪.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38944408" target='_blank' title="A critical appraisal of the role of metabolomics in breast cancer research and diagnostics.">A critical appraisal of the role of metabolomics in breast cancer research and diagnostics.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38950145" target='_blank' title="From Genotype to Phenotype: Raman Spectroscopy and Machine Learning for Label-Free Single-Cell Analysis.">From Genotype to Phenotype: Raman Spectroscopy and Machine Learning for Label-Free Single-Cell Analysis.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38847194" target='_blank' title="Electrolyte-gated amorphous IGZO transistors with extended gates for prostate-specific antigen detection.">Electrolyte-gated amorphous IGZO transistors with extended gates for prostate-specific antigen detection.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38847942" target='_blank' title="A Kernelized Classification Approach for Cancer Recognition Using Markovian Analysis of DNA Structure Patterns as Feature Mining.">A Kernelized Classification Approach for Cancer Recognition Using Markovian Analysis of DNA Structure Patterns as Feature Mining.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38850957" target='_blank' title="Identifying miRNA as biomarker for breast cancer subtyping using association rule.">Identifying miRNA as biomarker for breast cancer subtyping using association rule.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38844359" target='_blank' title="Is Automatic Tumor Segmentation on Whole-Body F-FDG PET Images a Clinical Reality?">Is Automatic Tumor Segmentation on Whole-Body F-FDG PET Images a Clinical Reality?</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38878752" target='_blank' title="Amonafide-based HO-responsive theranostic prodrugs: Exploring the correlation between HO level and anticancer efficacy.">Amonafide-based HO-responsive theranostic prodrugs: Exploring the correlation between HO level and anticancer efficacy.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38858307" target='_blank' title="Assessment of Biological Damage Induced during Multidetector Computed Tomography (MDCT) Examination.">Assessment of Biological Damage Induced during Multidetector Computed Tomography (MDCT) Examination.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38864687" target='_blank' title="Urinary PSA-ZINC biomarker outperforms standard of care in early detection of prostate cancer.">Urinary PSA-ZINC biomarker outperforms standard of care in early detection of prostate cancer.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38862927" target='_blank' title="Clinical application of targeted tumour sequencing tests for detecting ERBB2 amplification and optimizing anti-HER2 therapy in gastric cancer.">Clinical application of targeted tumour sequencing tests for detecting ERBB2 amplification and optimizing anti-HER2 therapy in gastric cancer.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38866774" target='_blank' title="CoHIT: a one-pot ultrasensitive ERA-CRISPR system for detecting multiple same-site indels.">CoHIT: a one-pot ultrasensitive ERA-CRISPR system for detecting multiple same-site indels.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38866366" target='_blank' title="Efficacy of blood plasma spectroscopy for early liver cancer diagnostics in obese patients.">Efficacy of blood plasma spectroscopy for early liver cancer diagnostics in obese patients.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38851426" target='_blank' title="Infectious complications in the paediatric immunocompromised host: a narrative review.">Infectious complications in the paediatric immunocompromised host: a narrative review.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38941688" target='_blank' title="Biocompatibility characterisation of CMOS-based Lab-on-Chip electrochemical sensors for in vitro cancer cell culture applications.">Biocompatibility characterisation of CMOS-based Lab-on-Chip electrochemical sensors for in vitro cancer cell culture applications.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38932267" target='_blank' title="HPV, HBV, and HIV-1 Viral Integration Site Mapping: A Streamlined Workflow from NGS to Genomic Insights of Carcinogenesis.">HPV, HBV, and HIV-1 Viral Integration Site Mapping: A Streamlined Workflow from NGS to Genomic Insights of Carcinogenesis.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38932179" target='_blank' title="Findings and Challenges in Replacing Traditional Uterine Cervical Cancer Diagnosis with Molecular Tools in Private Gynecological Practice in Mexico.">Findings and Challenges in Replacing Traditional Uterine Cervical Cancer Diagnosis with Molecular Tools in Private Gynecological Practice in Mexico.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38927646" target='_blank' title="Determinants of Chromatin Organization in Aging and Cancer-Emerging Opportunities for Epigenetic Therapies and AI Technology.">Determinants of Chromatin Organization in Aging and Cancer-Emerging Opportunities for Epigenetic Therapies and AI Technology.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38927132" target='_blank' title="Novel Semi-Nested Real-Time PCR Assay Leveraging Extendable Blocking Probes for Improved Methylation Analysis in Lung Cancer.">Novel Semi-Nested Real-Time PCR Assay Leveraging Extendable Blocking Probes for Improved Methylation Analysis in Lung Cancer.</a> </div> <p><strong>Issue Release:</strong> 2024</p> </div> <div class='publication-block'> <div style='margin-bottom: 10px;line-height: 24px;'> <a href="https://pubmed.ncbi.nlm.nih.gov/38917788" target='_blank' title="Pan-cancer proteogenomics expands the landscape of therapeutic targets.">Pan-cancer proteogenomics expands the landscape of therapeutic targets.</a> </div> 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class="slide"><a href="https://thepharma.net" title="The Pharma" target="_blank"><img src="https://thepharma.net/media-partners/thepharma.png" alt="The Pharma" title="The Pharma"></a></li> <li class="slide"><a href="https://infect.blog" title="Infectious Diseases" target="_blank"><img src="https://infect.blog/media-partners/infectious-disease.png" alt="Infectious Disease" title="Infectious Diseases"></a></li> <li class="slide"><a href="https://neurocare.blog" title="Neuro Care" target="_blank"><img src="https://neurocare.blog/media-partners/neurocare.png" alt="Neuro Care" title="Neuro Care"></a></li> <li class="slide"><a href="https://catalysis.blog" title="Catalysis" target="_blank"><img src="https://catalysis.blog/media-partners/catalysis.png" alt="Catalysis" title="Catalysis"></a></li> <li class="slide"><a href="https://neonatalbiology.com" title="Neonatal Biology" target="_blank"><img src="https://neonatalbiology.com/media-partners/neonatalbiology.png" alt="Neonatal Biology" 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src="https://renaldisorders.com/media-partners/renaldisorders.png" alt="Renal Disorders" title="Renal Disorders"></a></li> <li class="slide"><a href="https://theastrophysics.com" title="The Astrophysics" target="_blank"><img src="https://theastrophysics.com/media-partners/theastrophysics.png" alt="The Astrophysics" title="The Astrophysics"></a></li> <li class="slide"><a href="https://sleepphysiology.com" title="Sleep Physiology" target="_blank"><img src="https://sleepphysiology.com/media-partners/sleepphysiology.png" alt="Sleep Physiology" title="Sleep Physiology"></a></li> <li class="slide"><a href="https://epidemiology.blog" title="Epidemiology" target="_blank"><img src="https://epidemiology.blog/media-partners/epidemiology.png" alt="Epidemiology" title="Epidemiology"></a></li> <li class="slide"><a href="https://histology.blog" title="Histology" target="_blank"><img src="https://histology.blog/media-partners/histology.png" alt="Histology" title="Histology"></a></li> </ul> </div> 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