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-padding--horizontal -background--grey"> <div class="layout-columns__sidebar__content"> <div class="profile -full" data-module="sticky-sidebar" itemscope itemtype="http://schema.org/Person"> <div class="profile__content"> <h3 class="profile__name" itemprop="name"> Ryan J. Sullivan, MD</h3> <p class="profile__title" itemprop="jobTitle">Oncologist, Massachusetts General Hospital </br> Associate Professor, Medicine, Harvard Medical School </br> Associate Professor, Hematology/Oncology, Massachusetts General Hospital</p> </div> <p class="profile__image"> <img alt="Ryan J. Sullivan, MD" itemprop="image" srcset="/assets/images/contributors/ryan_sullivan_advances.png, /assets/images/contributors/ryan_sullivan_advances_2x.png 2x" src="/assets/images/contributors/ryan_sullivan_advances.png"> </p> </div> </div> </aside> <div class="layout-columns__main -padding--vertical -padding--horizontal" dcrname ="iwDCR0_261300"> <div class="layout-columns__main__content"> <h2 class="heading-h4">Posts by Ryan J. Sullivan, MD</h2> <ul class="content-tease__list"> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=2637" itemprop="url"> Case Series: Tofacitinib Is Effective in Treating Refractory Immune Checkpoint Inhibitor Hepatitis</a> </h3> <p itemprop="description"> <p><span>Ryan J. Sullivan, MD, Michael L. Dougan, MD, PhD, and colleagues have reported the first three cases of using a Janus kinase (JAK) inhibitor to treat hepatitis associated with immune checkpoint inhibitor therapy. All patients showed excellent response to tofacitinib, although their oncologic outcomes varied.</span></p></p> <p class="content-tease__related"> <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a>, <a href="/oncology/specialty.aspx?id=1008" itemprop="relatedLink">Oncology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2024-07-17" itemprop="datePublished">July 17, 2024</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/oncology/journal.aspx?id=2303" itemprop="url"> Palbociclib Demonstrates Activity Against Progressive Brain Metastases Harboring CDK Pathway Alterations</a> </h3> <p itemprop="description"> <p><span>A proof-of-concept study at the Massachusetts General Hospital Cancer Center showed genetic testing can guide treatment for patients with brain metastases from solid tumors, as 53% of patients with progressive brain metastases and CDK alterations showed benefit from palbociclib, a CDK inhibitor.</span></p></p> <p class="content-tease__related"> <a href="/oncology/specialty.aspx?id=1008" itemprop="relatedLink">Oncology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2022-08-22" itemprop="datePublished">August 22, 2022</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/oncology/journal.aspx?id=2301" itemprop="url"> Combination Checkpoint Inhibitor Therapy Safe, Extends Survival for Leptomeningeal Disease</a> </h3> <p itemprop="description"> <p><span>In a phase 2 trial, researchers at the Massachusetts General Hospital Cancer Center observed that the combination of two immune checkpoint inhibitors, ipilimumab and nivolumab, was safe and associated with three-month overall survival of 44% in a heavily pretreated population of patients with leptomeningeal disease.</span></p></p> <p class="content-tease__related"> <a href="/oncology/specialty.aspx?id=1008" itemprop="relatedLink">Oncology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2022-08-18" itemprop="datePublished">August 18, 2022</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemscope itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/oncology/journal.aspx?id=1922" itemprop="url"> Pembrolizumab Promising for Patients with Leptomeningeal Carcinomatosis</a> </h3> <p itemprop="description"> <p>Investigators at Massachusetts General Hospital are encouraged by the results of the first prospective clinical trial of an immune checkpoint inhibitor specifically for patients with leptomeningeal dissemination of solid tumors.</p></p> <p class="content-tease__related"> <a href="/neuro/specialty.aspx?id=1004" itemprop="relatedLink">Neuroscience</a>, <a href="/oncology/specialty.aspx?id=1008" itemprop="relatedLink">Oncology</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2021-05-05" itemprop="datePublished">May 5, 2021</time> </p> </div> </li> </ul> </div> </div> </section> <section class="-padding--vertical -padding--horizontal"> <div class="content-container -width--medium -centered"> <h2>Biography</h2> <p> Ryan J. Sullivan, MD, is an Oncologist at Massachusetts General Hospital and associate professor at Harvard Medical School.</p> <p class="fat-link__wrapper u-text-right"> <a class="fat-link -caret -large" href="https://www.massgeneral.org/doctors/19374/Ryan-Sullivan">View full profile</a> </p> </div> </section> <div class="content-container -width--xwide -centered specialty-block__wrapper" id="specialty-block"> <style> #specialty-block .specialty-block__image { /* 540px */ background-image: url(/assets/raw/specialty-block/cc-service2-2400.png); } only screen and (-webkit-min-device-pixel-ratio: 2), only screen and (min--moz-device-pixel-ratio: 2), only screen and (-moz-min-device-pixel-ratio: 2), only screen and (-o-min-device-pixel-ratio: 2/1), only screen and (min-device-pixel-ratio: 2), only screen and (min-resolution: 192dpi), only screen and (min-resolution: 2dppx) { #specialty-block .specialty-block__image { /* 1080 width */ background-image: 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